MCID: SCN045
MIFTS: 50

Secondary Amyloidosis malady

Genetic diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Rare diseases, Metabolic diseases, Blood diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Secondary Amyloidosis

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Sources:
48Orphanet, 61UMLS, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Secondary Amyloidosis:

Name: Secondary Amyloidosis 48
Reactive Systemic Amyloidosis 61
Inflammatory Amyloidosis 48
 
Reactive Amyloidosis 48
Amyloidosis Aa 48
Aa Amyloidosis 61


Classifications:



External Ids:

Orphanet48 85445
ICD10 via Orphanet26 E85.3
UMLS via Orphanet62 C0221014

Summaries for Secondary Amyloidosis

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MalaCards based summary: Secondary Amyloidosis, also known as reactive systemic amyloidosis, is related to amyloidosis and rheumatic disease. An important gene associated with Secondary Amyloidosis is SAA1 (serum amyloid A1), and among its related pathways are TRAF Pathway and MIF Action Through Endocytic Pathway. The compounds glucuronoxylomannan and tenidap have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and kidney, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Related Diseases for Secondary Amyloidosis

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Diseases in the Amyloidosis family:

Al Amyloidosis Amyloidosis Aa
Hereditary Amyloidosis secondary amyloidosis

Diseases related to Secondary Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.4MEFV, SAA1, SAA2, SAA4, CST3, ALB
2rheumatic disease30.7MEFV, IL1RN, CRP
3juvenile rheumatoid arthritis30.5IL1RN, CRP
4proteinuria30.5CRP, ALB, CST3, SAA4
5polymyalgia rheumatica30.5IL1RN, CRP
6poems syndrome30.5IL1B
7filariasis30.4TLR4, TLR2
8muckle-wells syndrome30.3IL1B, MEFV
9gingivitis30.2CST3, IL1B
10malaria30.1IL1RN, IL1B
11vasculitis30.1CD14, CRP, ALB, MEFV
12psoriatic arthritis30.0CRP, IL1B, TLR2
13tuberculosis30.0TLR2, TLR4, IL1B, ALB, CRP
14systemic lupus erythematosus29.9TLR2, TLR4, IL1RN, CRP
15gastritis29.9TLR2, TLR4, IL1RN, IL1B
16colitis29.9TLR2, TLR4, IL1RN, IL1B
17glomerulonephritis29.8IL1RN, IL1B, ALB
18arthritis29.7TLR2, TLR4, SAA4, SAA1, MEFV, IL1RN
19inflammatory bowel disease29.7TLR2, TLR4, IL1RN, IL1B
20myeloma29.5IL1B, CST3, CSF3, ALB, CD14
21periodontitis29.5TLR2, TLR4, IL1RN, IL1B, CD14
22ulcerative colitis29.5CD14, CRP, IL1B, IL1RN, TLR4, TLR2
23rheumatoid arthritis29.4TLR4, TLR2, SAA4, CD14, CRP, CST3
24periodontal disease29.3TLR2, TLR4, IL1RN, IL1B, CRP, CD14
25bacteriuria10.5CRP
26septic arthritis10.5CRP
27adult-onset still's disease10.5CRP
28palindromic rheumatism10.5MEFV
29hyper-igd syndrome10.5IL1RN
30appendicitis10.5CRP
31rheumatic fever10.5CRP
32polyarteritis nodosa10.5MEFV
33gastric cancer risk after h. pylori infection10.5IL1RN
34bronchiolitis10.5TLR4
35schnitzler syndrome10.5IL1RN
36dengue shock syndrome10.4IL1RN
37brucellosis10.4SAA1, MEFV
38crohn's disease10.4
39hepatorenal syndrome10.4ALB
40leukemoid reaction10.4CSF3
41leprosy10.4
42spondylitis10.4
43psoriasis10.3
44pyelonephritis10.3TLR4, CRP
45stomatitis10.3CSF3
46invasive aspergillosis10.3TLR2, TLR4
47exanthem10.3IL1RN, CRP
48spondylarthropathy10.3CRP, TLR4
49pouchitis10.3TLR2, TLR4
50melioidosis10.3TLR2, TLR4

Graphical network of the top 20 diseases related to Secondary Amyloidosis:



Diseases related to secondary amyloidosis

Symptoms for Secondary Amyloidosis

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Drugs & Therapeutics for Secondary Amyloidosis

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Drug clinical trials:

Search ClinicalTrials for Secondary Amyloidosis

Search NIH Clinical Center for Secondary Amyloidosis

Genetic Tests for Secondary Amyloidosis

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Anatomical Context for Secondary Amyloidosis

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MalaCards organs/tissues related to Secondary Amyloidosis:

31
Bone, Colon, Kidney, Skin, Spinal cord, Heart, Lung, Salivary gland, Myeloid, Bone marrow, Spleen, Liver, Testis, Testes, Endothelial

Animal Models for Secondary Amyloidosis or affiliated genes

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MGI Mouse Phenotypes related to Secondary Amyloidosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1TLR2, TLR4, IL1B, CST3, ALB
2MP:00053977.8CD14, CSF3, IL1B, IL1RN, MEFV, TLR4
3MP:00053907.6TLR2, TLR4, PAPPA, MEFV, IL1RN, IL1B
4MP:00053877.5TLR2, TLR4, MEFV, IL1RN, IL1B, CSF3
5MP:00053857.3TLR2, TLR4, PAPPA, IL1RN, IL1B, CST3
6MP:00053766.2CD14, TLR2, TLR4, PAPPA, SAA1, MEFV

Publications for Secondary Amyloidosis

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Articles related to Secondary Amyloidosis:

(show top 50)    (show all 251)
idTitleAuthorsYear
1
Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1I^ monoclonal antibody canakinumab. (24510061)
2014
2
Systemic secondary amyloidosis in a 70-year-old patient with Crohn's disease: treatment with oral budesonide. (23478807)
2013
3
A case of psoriasis with secondary amyloidosis, associated symbrachydactyly of the hand and a transverse deficiency of the foot. (22953651)
2012
4
Effects of secondary amyloidosis on arteriovenous hemodialysis fistula outcomes and intradialytic hypotension: a case-control study. (22360544)
2012
5
Interaction between periodontal disease and systemic secondary amyloidosis: from inflammation to amyloidosis. (21043797)
2011
6
Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and BehAset's disease. (19774408)
2010
7
Decrease in the rate of secondary amyloidosis in Turkish children with FMF: are we doing better? (20179967)
2010
8
Cystatin C is a sensitive marker for detecting a reduced glomerular filtration rate when assessing chronic kidney disease in patients with rheumatoid arthritis and secondary amyloidosis. (20132068)
2010
9
Chyloperitoneum: is secondary amyloidosis a possible cause? (19776056)
2009
10
Crohn's disease and secondary amyloidosis: early complication? A case report and review of the literature. (19689697)
2009
11
Hyporeninemic hypoaldosteronism from secondary amyloidosis. (18670413)
2008
12
Secondary amyloidosis in Crohn's disease: treatment with tumour necrosis factor inhibitor. (16407390)
2006
13
How long does it take for tuberculosis to cause secondary amyloidosis? (16198905)
2005
14
Lactoferrin Glu561Asp facilitates secondary amyloidosis in the cornea. (15923502)
2005
15
Association of secondary amyloidosis with common variable immune deficiency and tuberculosis. (16385663)
2005
16
Secondary amyloidosis as an unusual cause of ureteral obstruction. (14665926)
2004
17
Secondary amyloidosis and gastrointestinal stromal tumors. A case report and discussion of pathogenesis. (12683877)
2003
18
Prevalence of secondary amyloidosis in Asian North Indian patients with rheumatoid arthritis. (12734887)
2003
19
Fine needle aspiration biopsy for the diagnosis of secondary amyloidosis. (10934971)
2000
20
Combined treatment with cyclophosphamide and prednisolone is effective for secondary amyloidosis with SAA1I^/I^ genotype in a patient with rheumatoid arthritis. (24383594)
2000
21
Progressive multifocal leukoencephalopathy in a 15-year-old boy with scleroderma and secondary amyloidosis. (9832587)
1998
22
Endoscopic hydrostatic balloon dilation of ulcer-induced pyloric stenosis in rheumatoid arthritis and secondary amyloidosis. (9171133)
1997
23
Secondary amyloidosis in ankylosing spondylitis. A systematic survey of 137 patients using abdominal fat aspiration. (9150081)
1997
24
Secondary amyloidosis in the course of idiopathic myelofibrosis. (9393608)
1997
25
Secondary amyloidosis following juvenile chronic arthritis. (8772932)
1996
26
Characterization of serum amyloid A protein mRNA expression and secondary amyloidosis in the domestic duck. (8962089)
1996
27
Secondary amyloidosis of the urinary bladder: a rare cause of massive haematuria. (8602813)
1996
28
Secondary amyloidosis in patients with rheumatoid arthritis: diagnostic and prognostic value of gastroduodenal biopsy. (8624622)
1996
29
Secondary amyloidosis from long-standing bacterial endocarditis. (7742218)
1995
30
Multiple penetrating colonic ulcers in secondary amyloidosis caused by rheumatoid arthritis. (8465657)
1993
31
Splenic macrophage activation and functions in amyloid enhancing factor-induced secondary amyloidosis. Study of phagocytosis, killing, respiratory burst, and MHC class II surface expression. (8391054)
1993
32
Secondary amyloidosis involving the stomach in rheumatoid arthritis. (1316383)
1992
33
Severe secondary amyloidosis in a dog with dermatomyositis. (2474585)
1989
34
Hypocholesterolaemia in cases of nephrotic syndrome with secondary amyloidosis. (3171202)
1988
35
Secondary amyloidosis in association with Aspergillus lung disease. (3620326)
1986
36
Secondary amyloidosis: diagnosis from an endometrial biopsy. (6626292)
1983
37
Secondary amyloidosis and sicca syndrome. (7417359)
1980
38
Immunochemical studies on the nature of the serum component (SAA) related to secondary amyloidosis. (404372)
1977
39
Secondary amyloidosis developing after pancreaticoduodenal resection. (869480)
1977
40
Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis. (561759)
1977
41
Secondary amyloidosis due to Schistosoma mansoni infection. (1247859)
1976
42
Involvement of the autonomous nervous system in primary and secondary amyloidosis. (4684591)
1973
43
Congestive Cardiac Failure due to Secondary Amyloidosis. (20919065)
1969
44
Blastomycosis with secondary amyloidosis in the dog. (6067612)
1967
45
Frequency of secondary amyloidosis in hospital patients in Malawi. (4163492)
1966
46
URINARY-BRONCHOCUTANEOUS FISTULA WITH SECONDARY AMYLOIDOSIS. A COMPLICATION OF ATTEMPTED NEPHRECTOMY. (14269702)
1965
47
Electron microscopic observations on the localization of amyloid in the kidney in secondary amyloidosis. (13599445)
1958
48
Clinical studies of secondary amyloidosis in tuberculosis. (13239032)
1955
49
Hepatic manifestations in secondary amyloidosis. (15429434)
1950
50
Secondary amyloidosis in spinal cord injury. (15395456)
1949

Variations for Secondary Amyloidosis

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Expression for genes affiliated with Secondary Amyloidosis

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Search GEO for disease gene expression data for Secondary Amyloidosis.

Pathways for genes affiliated with Secondary Amyloidosis

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Pathways related to Secondary Amyloidosis according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CD14, TLR2
29.8CD14, TLR4
39.8CD14, TLR4
4
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway59
9.8CRP, IL1RN
5
Show member pathways
9.5SAA1, CD14, TLR4
69.5CSF3, IL1B
79.4TLR2, TLR4, CD14
8
Show member pathways
Vitamin B12 Metabolism36
9.4SAA2, SAA1, SAA4
99.3TLR4, CD14, IL1B
10
Show member pathways
9.3IL1B, TLR4, CD14
119.3TLR4, IL1B, CD14
129.3CD14, IL1B, TLR4
13
Show member pathways
Immune response MIF in innate immunity response59
9.3CD14, IL1B, TLR4
14
Show member pathways
9.3TLR2, IL1B, TLR4
15
Show member pathways
9.3TLR4, IL1B, TLR2
169.3TLR4, IL1B, TLR2
179.3IL1B, TLR4, TLR2
18
Show member pathways
9.3IL1B, TLR4, TLR2
19
Show member pathways
IL27-mediated signaling events36
9.3TLR2, IL1B, TLR4
20
Show member pathways
9.3TLR4, IL1B, TLR2
219.3TLR4, TLR2, IL1B
22
Show member pathways
9.3TLR4, CD14, CSF3
239.2CD14, CSF3, IL1B
24
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
9.0TLR2, TLR4, IL1B, CD14
259.0IL1B, CD14, TLR2, TLR4
26
Show member pathways
9.0IL1B, CD14, TLR4, TLR2
279.0TLR2, IL1B, TLR4, CD14
289.0IL1B, CD14, TLR4, TLR2
29
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0TLR2, CD14, IL1B, TLR4
30
Show member pathways
8.8CSF3, IL1B, TLR4, CD14
31
Show member pathways
8.7CSF3, IL1B, TLR4, TLR2
328.7IL1B, TLR2, TLR4, CSF3
33
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.6IL1B, CD14, IL1RN, TLR4, TLR2
34
Show member pathways
thioredoxin pathway36
8.1SAA1, ALB, IL1B, SAA2, SAA4, CRP

Compounds for genes affiliated with Secondary Amyloidosis

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Compounds related to Secondary Amyloidosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1glucuronoxylomannan449.8TLR4, TLR2, CD14
2tenidap44 2810.7IL1B, SAA1, CRP
3anakinra44 1110.5CRP, IL1B, IL1RN
4hbd2449.4IL1B, TLR4, TLR2
5muramyl dipeptide44 2810.4CD14, IL1B, TLR4, TLR2
6ramipril44 1110.3CST3, CRP, ALB
7amphotericin b449.3CRP, TLR2, CSF3, IL1RN
8gold sodium thiomalate449.3CD14, IL1B, IL1RN
9il 10449.2IL1B, IL1RN, TLR4, TLR2
10infliximab44 50 1111.2CRP, IL1B, IL1RN, TLR4
11zymosan449.2CST3, CD14, TLR4, IL1RN, TLR2
12simvastatin44 50 60 28 24 1114.1CRP, TLR2, TLR4, SAA1, IL1RN
13aopp449.1PAPPA, ALB, CRP
14ivig449.1CRP, IL1RN, ALB, IL1B
15polymyxin b449.0TLR4, TLR2, IL1B, CD14, IL1RN
16pentosidine449.0ALB, CRP, PAPPA
17lipoteichoic acid449.0IL1RN, TLR4, CD14, IL1B, TLR2
18peptidoglycan44 2810.0CD14, IL1B, IL1RN, TLR4, TLR2
19ccl344 2810.0CSF3, TLR2, TLR4, IL1B
20polyethylene glycol449.0IL1RN, ALB, CRP, CST3
21neopterin448.8CRP, SAA4, IL1RN, IL1B, CD14
22prednisolone44 28 1110.8CRP, CD14, ALB, CSF3, IL1RN
23homocysteine44 249.8SAA4, ALB, CST3, CRP, CD14
24uric acid44 249.8CRP, ALB, CST3, SAA4
25fmlp448.8TLR4, CSF3, IL1B, IL1RN, CD14
26p002448.7CD14, CRP, PAPPA, CST3, IL1RN
27calcitriol44 60 24 1111.7ALB, CD14, IL1B, TLR4, TLR2
28sb 20358044 609.7TLR4, CRP, IL1RN, IL1B, TLR2
29polysulfone448.7CD14, CRP, CST3, ALB, IL1RN, IL1B
30mannose448.6TLR2, TLR4, PAPPA, CD14, IL1RN
31cyclosporin a44 28 6010.6CD14, TLR2, TLR4, CST3, CSF3, IL1RN
32lactate448.6TLR4, IL1RN, CST3, ALB, CRP, CD14
33rantes448.5CSF3, IL1B, CD14, TLR2, TLR4, IL1RN
34histamine44 28 2410.4CD14, ALB, IL1B, IL1RN, TLR4, TLR2
35latex448.3SAA4, CD14, CRP, TLR2, TLR4, CST3
36vitamin d448.2ALB, TLR4, TLR2, CD14, IL1RN
37superoxide44 249.2TLR4, TLR2, IL1RN, IL1B, CD14, CSF3
38cycloheximide448.2TLR2, TLR4, IL1B, CSF3, CRP, CD14
39alanine448.1TLR4, SAA1, CST3, IL1RN, CRP, TLR2
40methotrexate50 44 1110.0CSF3, TLR4, ALB, CRP, IL1RN, IL1B
41creatinine447.6CST3, ALB, CRP, CD14, SAA4, PAPPA
42cysteine447.6TLR2, TLR4, PAPPA, IL1RN, CST3, ALB
43fibrinogen447.5CST3, IL1RN, TLR2, TLR4, SAA4, SAA1
44endotoxin447.1CRP, CSF3, IL1B, IL1RN, SAA1, SAA4
45vegf447.1TLR2, TLR4, PAPPA, IL1RN, IL1B, CST3
46glucose447.0TLR2, CD14, CRP, ALB, CST3, SAA4
47cholesterol44 28 24 119.7PAPPA, TLR2, TLR4, SAA4, ALB, SAA1
48lipid446.7IL1RN, TLR2, TLR4, PAPPA, SAA4, SAA1
49calcium44 50 24 119.6TLR2, TLR4, CD14, SAA4, PAPPA, IL1RN
50dexamethasone44 50 28 119.3CD14, TLR2, CST3, TLR4, PAPPA, SAA4

GO Terms for genes affiliated with Secondary Amyloidosis

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Cellular components related to Secondary Amyloidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:00343649.4SAA1, SAA2, SAA4
2extracellular spaceGO:00056156.8CD14, PAPPA, IL1RN, IL1B, CST3, CSF3
3extracellular regionGO:00055766.6PAPPA, SAA4, SAA1, IL1B, CST3, ALB

Biological processes related to Secondary Amyloidosis according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-12 productionGO:003269510.1TLR2, MEFV
2positive regulation of macrophage cytokine productionGO:006090710.0TLR4, TLR2
3negative regulation of interleukin-17 productionGO:003270010.0TLR2, TLR4
4fever generationGO:000166010.0IL1B, IL1RN
5positive regulation of tumor necrosis factor biosynthetic processGO:004253510.0TLR2, TLR4
6positive regulation of cytokine secretionGO:005071510.0SAA1, TLR2, CD14
7positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.0TLR4, TLR2
8I-kappaB phosphorylationGO:000725210.0TLR4, TLR2
9positive regulation of chemokine productionGO:00327229.9TLR2, TLR4
10positive regulation of interleukin-10 productionGO:00327339.9TLR4, TLR2
11cellular response to lipoteichoic acidGO:00712239.8CD14, TLR2, TLR4
12positive regulation of interferon-beta productionGO:00327289.8TLR2, TLR4
13defense response to Gram-positive bacteriumGO:00508309.8CRP, TLR2
14positive regulation of tumor necrosis factor productionGO:00327609.8CD14, TLR4, TLR2
15toll-like receptor TLR1:TLR2 signaling pathwayGO:00381239.8CD14, TLR2, TLR4
16positive regulation of interleukin-12 productionGO:00327359.8TLR4, TLR2
17toll-like receptor TLR6:TLR2 signaling pathwayGO:00381249.8TLR2, CD14, TLR4
18neutrophil chemotaxisGO:00305939.8SAA1, IL1B
19toll-like receptor 2 signaling pathwayGO:00341349.8TLR2, CD14, TLR4
20MyD88-dependent toll-like receptor signaling pathwayGO:00027559.8CD14, TLR4, TLR2
21toll-like receptor 4 signaling pathwayGO:00341429.7CD14, TLR2, TLR4
22toll-like receptor signaling pathwayGO:00022249.7TLR2, TLR4, CD14
23positive regulation of NF-kappaB import into nucleusGO:00423469.7TLR2, TLR4, IL1B
24positive regulation of interleukin-8 productionGO:00327579.7TLR2, IL1B, TLR4
25lipopolysaccharide-mediated signaling pathwayGO:00316639.6TLR4, TLR2, IL1B
26positive regulation of nitric oxide biosynthetic processGO:00454299.6TLR2, TLR4, IL1B
27positive regulation of interleukin-6 productionGO:00327559.6TLR2, TLR4, IL1B
28cellular response to lipopolysaccharideGO:00712229.6CSF3, TLR4, CD14
29positive regulation of interferon-gamma productionGO:00327299.5IL1B, TLR4
30positive regulation of NF-kappaB transcription factor activityGO:00510929.5TLR4, TLR2, IL1B
31innate immune responseGO:00450879.3MEFV, TLR2, TLR4, SAA1, CD14
32inflammatory responseGO:00069549.2CRP, MEFV, CD14, TLR2, IL1B
33acute-phase responseGO:00069539.1SAA4, SAA2, SAA1, IL1RN, CRP
34immune responseGO:00069558.8TLR2, TLR4, IL1RN, IL1B, CSF3
35positive regulation of transcription from RNA polymerase II promoterGO:00459448.4CSF3, IL1B, TLR4, TLR2

Molecular functions related to Secondary Amyloidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:00708919.8CD14, TLR2
2lipopolysaccharide bindingGO:00015309.8CD14, TLR4
3lipopolysaccharide receptor activityGO:00018759.6TLR4, TLR2
4interleukin-1 receptor bindingGO:00051499.3IL1B, IL1RN

Sources for Secondary Amyloidosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet