MCID: SCN045
MIFTS: 56

Secondary Amyloidosis malady

Genetic diseases, Neuronal diseases, Nephrological diseases, Bone diseases, Rare diseases, Metabolic diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Secondary Amyloidosis

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MalaCards based summary: Secondary Amyloidosis, also known as inflammatory amyloidosis, is related to amyloidosis and arthritis. An important gene associated with Secondary Amyloidosis is SAA1 (serum amyloid A1), and among its related pathways are TRAF Pathway and A-beta Uptake and Degradation. The compounds glucuronoxylomannan and tenidap have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and kidney, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Aliases & Classifications for Secondary Amyloidosis

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Sources:
49Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Secondary Amyloidosis, Aliases & Descriptions:

Name: Secondary Amyloidosis 49
Inflammatory Amyloidosis 49
 
Reactive Amyloidosis 49
Amyloidosis Aa 49


Classifications:



External Ids:

Orphanet49 85445
ICD10 via Orphanet28 E85.3
UMLS via Orphanet63 C0221014

Related Diseases for Secondary Amyloidosis

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Diseases in the Amyloidosis family:

Al Amyloidosis Amyloidosis Aa
Hereditary Amyloidosis secondary amyloidosis

Diseases related to Secondary Amyloidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.7ALB, SAA4, CRP, SAA2, SAA1, MEFV
2arthritis30.9IL1RN, ALB, IL1B, CRP, TLR2, TLR4
3rheumatoid arthritis30.8SAA4, CST3, TLR4, SAA2, TLR2, SAA1
4tuberculosis30.5CRP, ALB, IL1B, TLR2, TLR4
5proteinuria30.4SAA4, ALB, CRP, CST3
6rheumatic disease30.4CRP, MEFV, IL1RN
7juvenile rheumatoid arthritis30.2CRP, IL1RN
8gastritis30.2IL1B, IL1RN, TLR4, TLR2
9colitis30.2IL1RN, TLR4, TLR2, IL1B
10myeloma30.1ALB, IL1B, CST3, CSF3, CD14
11ulcerative colitis30.1CD14, CRP, IL1B, TLR4, IL1RN, TLR2
12poems syndrome30.1IL1B
13polymyalgia rheumatica30.0CRP, IL1RN
14filariasis30.0TLR2, TLR4
15muckle-wells syndrome30.0IL1B, MEFV
16gingivitis30.0CST3, IL1B
17malaria30.0IL1RN, IL1B
18vasculitis30.0MEFV, ALB, CRP, CD14
19psoriatic arthritis30.0IL1B, TLR2, CRP
20systemic lupus erythematosus30.0CRP, IL1RN, TLR4, TLR2
21glomerulonephritis30.0ALB, IL1RN, IL1B
22inflammatory bowel disease29.9IL1B, TLR4, IL1RN, TLR2
23periodontitis29.9IL1B, CD14, TLR2, IL1RN, TLR4
24periodontal disease29.9IL1B, IL1RN, TLR2, CRP, CD14, TLR4
25crohn's disease10.4
26leprosy10.4
27spondylitis10.4
28psoriasis10.3
29nephrotic syndrome10.3
30hepatitis10.2
31osteomyelitis10.2
32cystic fibrosis10.1
33spinal cord injury10.1
34achalasia10.1
35diarrhea10.1
36epidermolysis bullosa10.1
37lupus erythematosus10.1
38neuropathy10.1
39scleroderma10.1
40amyloidosis aa10.1
41castleman's disease10.1
42nodular nonsuppurative panniculitis10.1
43panniculitis10.1
44bacteriuria10.1CRP
45septic arthritis10.1CRP
46adult-onset still's disease10.1CRP
47palindromic rheumatism10.1MEFV
48hyper-igd syndrome10.1IL1RN
49appendicitis10.1CRP
50rheumatic fever10.1CRP

Graphical network of the top 20 diseases related to Secondary Amyloidosis:



Diseases related to secondary amyloidosis

Symptoms for Secondary Amyloidosis

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Drugs & Therapeutics for Secondary Amyloidosis

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Drug clinical trials:

Search ClinicalTrials for Secondary Amyloidosis

Search NIH Clinical Center for Secondary Amyloidosis

Genetic Tests for Secondary Amyloidosis

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Anatomical Context for Secondary Amyloidosis

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MalaCards organs/tissues related to Secondary Amyloidosis:

33
Bone, Colon, Kidney, Skin, Spinal cord, Heart, Lung, Salivary gland, Myeloid, Bone marrow, Spleen, Liver, Testis, Testes, Endothelial

Animal Models for Secondary Amyloidosis or affiliated genes

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MGI Mouse Phenotypes related to Secondary Amyloidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1TLR2, TLR4, IL1B, CST3, ALB
2MP:00053977.8CD14, CSF3, IL1B, IL1RN, MEFV, TLR4
3MP:00053907.6TLR2, TLR4, PAPPA, MEFV, IL1RN, IL1B
4MP:00053877.5TLR2, TLR4, MEFV, IL1RN, IL1B, CSF3
5MP:00053857.3TLR2, TLR4, PAPPA, IL1RN, IL1B, CST3
6MP:00053766.2CD14, TLR2, TLR4, PAPPA, SAA1, MEFV

Publications for Secondary Amyloidosis

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Articles related to Secondary Amyloidosis:

(show top 50)    (show all 251)
idTitleAuthorsYear
1
Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1I^ monoclonal antibody canakinumab. (24510061)
2014
2
Systemic secondary amyloidosis in a 70-year-old patient with Crohn's disease: treatment with oral budesonide. (23478807)
2013
3
A case of psoriasis with secondary amyloidosis, associated symbrachydactyly of the hand and a transverse deficiency of the foot. (22953651)
2012
4
Effects of secondary amyloidosis on arteriovenous hemodialysis fistula outcomes and intradialytic hypotension: a case-control study. (22360544)
2012
5
Interaction between periodontal disease and systemic secondary amyloidosis: from inflammation to amyloidosis. (21043797)
2011
6
Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and BehAset's disease. (19774408)
2010
7
Decrease in the rate of secondary amyloidosis in Turkish children with FMF: are we doing better? (20179967)
2010
8
Cystatin C is a sensitive marker for detecting a reduced glomerular filtration rate when assessing chronic kidney disease in patients with rheumatoid arthritis and secondary amyloidosis. (20132068)
2010
9
Chyloperitoneum: is secondary amyloidosis a possible cause? (19776056)
2009
10
Crohn's disease and secondary amyloidosis: early complication? A case report and review of the literature. (19689697)
2009
11
Hyporeninemic hypoaldosteronism from secondary amyloidosis. (18670413)
2008
12
Secondary amyloidosis in Crohn's disease: treatment with tumour necrosis factor inhibitor. (16407390)
2006
13
How long does it take for tuberculosis to cause secondary amyloidosis? (16198905)
2005
14
Lactoferrin Glu561Asp facilitates secondary amyloidosis in the cornea. (15923502)
2005
15
Association of secondary amyloidosis with common variable immune deficiency and tuberculosis. (16385663)
2005
16
Secondary amyloidosis as an unusual cause of ureteral obstruction. (14665926)
2004
17
Secondary amyloidosis and gastrointestinal stromal tumors. A case report and discussion of pathogenesis. (12683877)
2003
18
Prevalence of secondary amyloidosis in Asian North Indian patients with rheumatoid arthritis. (12734887)
2003
19
Fine needle aspiration biopsy for the diagnosis of secondary amyloidosis. (10934971)
2000
20
Combined treatment with cyclophosphamide and prednisolone is effective for secondary amyloidosis with SAA1I^/I^ genotype in a patient with rheumatoid arthritis. (24383594)
2000
21
Progressive multifocal leukoencephalopathy in a 15-year-old boy with scleroderma and secondary amyloidosis. (9832587)
1998
22
Endoscopic hydrostatic balloon dilation of ulcer-induced pyloric stenosis in rheumatoid arthritis and secondary amyloidosis. (9171133)
1997
23
Secondary amyloidosis in ankylosing spondylitis. A systematic survey of 137 patients using abdominal fat aspiration. (9150081)
1997
24
Secondary amyloidosis in the course of idiopathic myelofibrosis. (9393608)
1997
25
Secondary amyloidosis following juvenile chronic arthritis. (8772932)
1996
26
Characterization of serum amyloid A protein mRNA expression and secondary amyloidosis in the domestic duck. (8962089)
1996
27
Secondary amyloidosis of the urinary bladder: a rare cause of massive haematuria. (8602813)
1996
28
Secondary amyloidosis in patients with rheumatoid arthritis: diagnostic and prognostic value of gastroduodenal biopsy. (8624622)
1996
29
Secondary amyloidosis from long-standing bacterial endocarditis. (7742218)
1995
30
Multiple penetrating colonic ulcers in secondary amyloidosis caused by rheumatoid arthritis. (8465657)
1993
31
Splenic macrophage activation and functions in amyloid enhancing factor-induced secondary amyloidosis. Study of phagocytosis, killing, respiratory burst, and MHC class II surface expression. (8391054)
1993
32
Secondary amyloidosis involving the stomach in rheumatoid arthritis. (1316383)
1992
33
Severe secondary amyloidosis in a dog with dermatomyositis. (2474585)
1989
34
Hypocholesterolaemia in cases of nephrotic syndrome with secondary amyloidosis. (3171202)
1988
35
Secondary amyloidosis in association with Aspergillus lung disease. (3620326)
1986
36
Secondary amyloidosis: diagnosis from an endometrial biopsy. (6626292)
1983
37
Secondary amyloidosis and sicca syndrome. (7417359)
1980
38
Immunochemical studies on the nature of the serum component (SAA) related to secondary amyloidosis. (404372)
1977
39
Secondary amyloidosis developing after pancreaticoduodenal resection. (869480)
1977
40
Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis. (561759)
1977
41
Secondary amyloidosis due to Schistosoma mansoni infection. (1247859)
1976
42
Involvement of the autonomous nervous system in primary and secondary amyloidosis. (4684591)
1973
43
Congestive Cardiac Failure due to Secondary Amyloidosis. (20919065)
1969
44
Blastomycosis with secondary amyloidosis in the dog. (6067612)
1967
45
Frequency of secondary amyloidosis in hospital patients in Malawi. (4163492)
1966
46
URINARY-BRONCHOCUTANEOUS FISTULA WITH SECONDARY AMYLOIDOSIS. A COMPLICATION OF ATTEMPTED NEPHRECTOMY. (14269702)
1965
47
Electron microscopic observations on the localization of amyloid in the kidney in secondary amyloidosis. (13599445)
1958
48
Clinical studies of secondary amyloidosis in tuberculosis. (13239032)
1955
49
Hepatic manifestations in secondary amyloidosis. (15429434)
1950
50
Secondary amyloidosis in spinal cord injury. (15395456)
1949

Variations for Secondary Amyloidosis

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Expression for genes affiliated with Secondary Amyloidosis

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Search GEO for disease gene expression data for Secondary Amyloidosis.

Pathways for genes affiliated with Secondary Amyloidosis

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Pathways related to Secondary Amyloidosis according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8TLR2, CD14
29.8TLR4, CD14
39.8CD14, TLR4
4
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.8CRP, IL1RN
5
Show member pathways
9.5CD14, SAA1, TLR4
69.5CSF3, IL1B
79.4CD14, TLR4, TLR2
8
Show member pathways
Vitamin B12 Metabolism38
9.4SAA1, SAA2, SAA4
99.3TLR4, IL1B, CD14
10
Show member pathways
Immune response MIF in innate immunity response60
9.3TLR4, IL1B, CD14
119.3TLR4, IL1B, CD14
12
Show member pathways
9.3TLR4, IL1B, CD14
139.3CD14, IL1B, TLR4
14
Show member pathways
9.3TLR2, TLR4, IL1B
159.3IL1B, TLR4, TLR2
169.3TLR2, TLR4, IL1B
179.3IL1B, TLR4, TLR2
18
Show member pathways
9.3TLR2, TLR4, IL1B
19
Show member pathways
9.3IL1B, TLR4, TLR2
20
Show member pathways
IL27-mediated signaling events38
9.3IL1B, TLR4, TLR2
21
Show member pathways
9.3IL1B, TLR4, TLR2
22
Show member pathways
9.3TLR4, CSF3, CD14
239.2IL1B, CSF3, CD14
24
Show member pathways
9.0TLR2, TLR4, IL1B, CD14
259.0TLR2, TLR4, IL1B, CD14
26
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.0TLR2, TLR4, IL1B, CD14
27
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0TLR2, TLR4, IL1B, CD14
289.0CD14, IL1B, TLR4, TLR2
299.0CD14, IL1B, TLR4, TLR2
30
Show member pathways
8.8CD14, CSF3, IL1B, TLR4
318.7TLR2, TLR4, IL1B, CSF3
32
Show member pathways
8.7TLR2, TLR4, IL1B, CSF3
33
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.6TLR2, TLR4, IL1RN, IL1B, CD14
34
Show member pathways
thioredoxin pathway38
8.1CRP, ALB, IL1B, SAA1, SAA2, SAA4

Compounds for genes affiliated with Secondary Amyloidosis

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Compounds related to Secondary Amyloidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1glucuronoxylomannan459.8TLR4, TLR2, CD14
2tenidap45 3010.7IL1B, SAA1, CRP
3anakinra45 1310.5CRP, IL1B, IL1RN
4hbd2459.4IL1B, TLR4, TLR2
5muramyl dipeptide45 3010.4CD14, IL1B, TLR4, TLR2
6ramipril45 1310.3CST3, CRP, ALB
7amphotericin b459.3CRP, TLR2, CSF3, IL1RN
8gold sodium thiomalate459.3CD14, IL1B, IL1RN
9il 10459.2IL1B, IL1RN, TLR4, TLR2
10infliximab45 51 1311.2CRP, IL1B, IL1RN, TLR4
11zymosan459.2CST3, CD14, TLR4, IL1RN, TLR2
12simvastatin45 51 61 30 26 1314.1CRP, TLR2, TLR4, SAA1, IL1RN
13aopp459.1PAPPA, ALB, CRP
14ivig459.1CRP, IL1RN, ALB, IL1B
15polymyxin b459.0TLR4, TLR2, IL1B, CD14, IL1RN
16pentosidine459.0ALB, CRP, PAPPA
17lipoteichoic acid459.0IL1RN, TLR4, CD14, IL1B, TLR2
18peptidoglycan45 3010.0CD14, IL1B, IL1RN, TLR4, TLR2
19ccl345 3010.0CSF3, TLR2, TLR4, IL1B
20polyethylene glycol459.0IL1RN, ALB, CRP, CST3
21neopterin458.8CRP, SAA4, IL1RN, IL1B, CD14
22prednisolone45 30 1310.8CRP, CD14, ALB, CSF3, IL1RN
23homocysteine45 269.8SAA4, ALB, CST3, CRP, CD14
24uric acid45 269.8CRP, ALB, CST3, SAA4
25fmlp458.8TLR4, CSF3, IL1B, IL1RN, CD14
26p002458.7CD14, CRP, PAPPA, CST3, IL1RN
27calcitriol45 61 26 1311.7ALB, CD14, IL1B, TLR4, TLR2
28sb 20358045 619.7TLR4, CRP, IL1RN, IL1B, TLR2
29polysulfone458.7CD14, CRP, CST3, ALB, IL1RN, IL1B
30mannose458.6TLR2, TLR4, PAPPA, CD14, IL1RN
31cyclosporin a45 30 6110.6CD14, TLR2, TLR4, CST3, CSF3, IL1RN
32lactate458.6TLR4, IL1RN, CST3, ALB, CRP, CD14
33rantes458.5CSF3, IL1B, CD14, TLR2, TLR4, IL1RN
34histamine45 30 2610.4CD14, ALB, IL1B, IL1RN, TLR4, TLR2
35latex458.3SAA4, CD14, CRP, TLR2, TLR4, CST3
36vitamin d458.2ALB, TLR4, TLR2, CD14, IL1RN
37superoxide45 269.2TLR4, TLR2, IL1RN, IL1B, CD14, CSF3
38cycloheximide458.2TLR2, TLR4, IL1B, CSF3, CRP, CD14
39alanine458.1TLR4, SAA1, CST3, IL1RN, CRP, TLR2
40methotrexate51 45 1310.0CSF3, TLR4, ALB, CRP, IL1RN, IL1B
41creatinine457.6CST3, ALB, CRP, CD14, SAA4, PAPPA
42cysteine457.6TLR2, TLR4, PAPPA, IL1RN, CST3, ALB
43fibrinogen457.5CST3, IL1RN, TLR2, TLR4, SAA4, SAA1
44endotoxin457.1CRP, CSF3, IL1B, IL1RN, SAA1, SAA4
45vegf457.1TLR2, TLR4, PAPPA, IL1RN, IL1B, CST3
46glucose457.0TLR2, CD14, CRP, ALB, CST3, SAA4
47cholesterol45 30 26 139.7PAPPA, TLR2, TLR4, SAA4, ALB, SAA1
48lipid456.7IL1RN, TLR2, TLR4, PAPPA, SAA4, SAA1
49calcium45 51 26 139.6TLR2, TLR4, CD14, SAA4, PAPPA, IL1RN
50dexamethasone45 51 30 139.3CD14, TLR2, CST3, TLR4, PAPPA, SAA4

GO Terms for genes affiliated with Secondary Amyloidosis

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Cellular components related to Secondary Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particleGO:00343649.4SAA1, SAA2, SAA4
2extracellular spaceGO:00056156.8CD14, PAPPA, IL1RN, IL1B, CST3, CSF3
3extracellular regionGO:00055766.6PAPPA, SAA4, SAA1, IL1B, CST3, ALB

Biological processes related to Secondary Amyloidosis according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-12 productionGO:003269510.1MEFV, TLR2
2positive regulation of macrophage cytokine productionGO:006090710.0TLR2, TLR4
3negative regulation of interleukin-17 productionGO:003270010.0TLR4, TLR2
4fever generationGO:000166010.0IL1B, IL1RN
5positive regulation of tumor necrosis factor biosynthetic processGO:004253510.0TLR2, TLR4
6positive regulation of cytokine secretionGO:005071510.0TLR2, SAA1, CD14
7positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.0TLR2, TLR4
8I-kappaB phosphorylationGO:000725210.0TLR2, TLR4
9positive regulation of chemokine productionGO:00327229.9TLR4, TLR2
10positive regulation of interleukin-10 productionGO:00327339.9TLR4, TLR2
11cellular response to lipoteichoic acidGO:00712239.8TLR2, TLR4, CD14
12positive regulation of interferon-beta productionGO:00327289.8TLR2, TLR4
13defense response to Gram-positive bacteriumGO:00508309.8CRP, TLR2
14positive regulation of tumor necrosis factor productionGO:00327609.8CD14, TLR4, TLR2
15toll-like receptor TLR6:TLR2 signaling pathwayGO:00381249.8TLR2, TLR4, CD14
16positive regulation of interleukin-12 productionGO:00327359.8TLR4, TLR2
17toll-like receptor TLR1:TLR2 signaling pathwayGO:00381239.8TLR2, TLR4, CD14
18neutrophil chemotaxisGO:00305939.8IL1B, SAA1
19toll-like receptor 2 signaling pathwayGO:00341349.8TLR2, TLR4, CD14
20MyD88-dependent toll-like receptor signaling pathwayGO:00027559.8CD14, TLR4, TLR2
21toll-like receptor 4 signaling pathwayGO:00341429.7CD14, TLR4, TLR2
22toll-like receptor signaling pathwayGO:00022249.7CD14, TLR4, TLR2
23positive regulation of NF-kappaB import into nucleusGO:00423469.7TLR2, TLR4, IL1B
24positive regulation of interleukin-8 productionGO:00327579.7TLR2, TLR4, IL1B
25lipopolysaccharide-mediated signaling pathwayGO:00316639.6IL1B, TLR4, TLR2
26positive regulation of nitric oxide biosynthetic processGO:00454299.6TLR2, TLR4, IL1B
27positive regulation of interleukin-6 productionGO:00327559.6TLR2, TLR4, IL1B
28cellular response to lipopolysaccharideGO:00712229.6CD14, CSF3, TLR4
29positive regulation of interferon-gamma productionGO:00327299.5TLR4, IL1B
30positive regulation of NF-kappaB transcription factor activityGO:00510929.5TLR2, TLR4, IL1B
31innate immune responseGO:00450879.3TLR2, TLR4, SAA1, MEFV, CD14
32inflammatory responseGO:00069549.2TLR2, MEFV, IL1B, CRP, CD14
33acute-phase responseGO:00069539.1CRP, IL1RN, SAA1, SAA2, SAA4
34immune responseGO:00069558.8CSF3, IL1B, IL1RN, TLR4, TLR2
35positive regulation of transcription from RNA polymerase II promoterGO:00459448.4CSF3, IL1B, TLR4, TLR2

Molecular functions related to Secondary Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoteichoic acid bindingGO:00708919.8CD14, TLR2
2lipopolysaccharide bindingGO:00015309.8CD14, TLR4
3lipopolysaccharide receptor activityGO:00018759.6TLR4, TLR2
4interleukin-1 receptor bindingGO:00051499.3IL1B, IL1RN

Products for genes affiliated with Secondary Amyloidosis

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Sources for Secondary Amyloidosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet