MCID: SCR003
MIFTS: 36

Secretory Diarrhea malady

Summaries for Secretory Diarrhea

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. the most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards: Secretory Diarrhea is related to diarrhea and cholera. An important gene associated with Secretory Diarrhea is SST (somatostatin), and among its related pathways are NO-dependent CFTR activation (normal and CF) and Clathrin-dependent protein traffic. The compounds clofilium and chromanol 293b have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and bone, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Secretory Diarrhea

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8Disease Ontology, 10DISEASES, 60UMLS
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Aliases & Descriptions:

secretory diarrhea 8 10 60


External Ids:

Disease Ontology8 DOID:0050129

Related Diseases for Secretory Diarrhea

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to secretory diarrhea

Clinical Features for Secretory Diarrhea

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Drugs & Therapeutics for Secretory Diarrhea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Secretory Diarrhea

Drug clinical trials:

Search ClinicalTrials for Secretory Diarrhea

Search NIH Clinical Center for Secretory Diarrhea

Search CenterWatch for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

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Anatomical Context for Secretory Diarrhea

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32MalaCards
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MalaCards organs/tissues related to Secretory Diarrhea:

32
Colon, Bone marrow, Bone, Small intestine, Skin

Animal Models for Secretory Diarrhea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Secretory Diarrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5CFTR, KCNN4, KCNQ1, FOXP3, PRKG2, SST
2MP:00053767.4KCNQ1, FOXP3, PRKG2, SST, CFTR, SLC9A3R2
3MP:00053787.4KCNQ1, FOXP3, LPAR2, PRKG2, SHANK2, SST

Publications for Secretory Diarrhea

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50PubMed
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Articles related to Secretory Diarrhea:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Crofelemer for the treatment of secretory diarrhea. (22149578)
2012
2
Intractable secretory diarrhea in a Japanese boy with mitochondrial respiratory chain complex I deficiency. (18560889)
2009
3
We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors. (17435618)
2007
4
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. (16614995)
2006
5
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions. (16203867)
2005
6
Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. (15342979)
2004
7
Legionella micdadei infection presenting as severe secretory diarrhea and a solitary pulmonary mass. (15034849)
2004
8
Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. (15097437)
2004
9
Secretory diarrhea owing to a tape bezoar in a child with Hirschsprung's disease. (14614723)
2003
10
Congenital myopathy, recurrent secretory diarrhea, bullous eruption of skin, microcephaly, and deafness: a new genetic syndrome? (12476446)
2003
11
Acute appendicitis presenting as secretory diarrhea. (12037768)
2002
12
Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. (12044816)
2002
13
Continuous octreotide infusion for the treatment of secretory diarrhea caused by acute intestinal graft-versus-host disease in a child. (10959906)
2000
14
Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. (9586761)
1998
15
Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. (9541283)
1998
16
Lansoprazole: a cause of secretory diarrhea. (9820425)
1998
17
Secretory diarrhea in children: newly recognized toxins and hormone-secreting tumors. (8614604)
1996
18
A pharmacological approach to secretory diarrhea. (7743122)
1995
19
Consensus statement: octreotide dose titration in secretory diarrhea. Diarrhea Management Consensus Development Panel. (7628270)
1995
20
Human intestinal cryptosporidiosis: secretory diarrhea and enterotoxic activity in Caco-2 cells. (7706827)
1995
21
Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. (8385040)
1993
22
Sigmoid volvulus presenting as chronic secretory diarrhea responsive to octreotide. (1728114)
1992
23
The effect of nifedipine on secretory diarrhea in mice. (1440948)
1992
24
Secretory diarrhea and candidal overgrowth: cause and effect? (1894948)
1991
25
Relation between small intestinal motor activity and transit in secretory diarrhea. (2399985)
1990
26
Severe secretory diarrhea with elevated gastrin-releasing peptide controlled by somatostatin analogue: a case report. (1980089)
1990
27
The somatostatin analog octreotide in the management of the secretory diarrhea of the acute intestinal graft-versus-host disease in a patient after bone marrow transplantation. (2360261)
1990
28
Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. (2214801)
1990
29
Alanine stimulation of water and sodium absorption in a model of secretory diarrhea. (2303972)
1990
30
Treatment of secretory diarrhea in AIDS with the somatostatin analogue SMS 201-995. (2724869)
1989
31
Secretory diarrhea in Crohn's disease with concurrent giardiasis. (2738361)
1989
32
Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. (2795459)
1989
33
Characteristics and mechanism of action of a heat-stable enterotoxin produced by Klebsiella pneumoniae from infants with secretory diarrhea. (2470015)
1989
34
Successful treatment of idiopathic secretory diarrhea of infancy with the somatostatin analogue SMS 201-995. (2891583)
1988
35
Efficacy of oral rehydration solutions in a rat model of secretory diarrhea. (3430270)
1987
36
Secretory diarrhea and thyrotoxicosis. (3800200)
1987
37
Migrating action potential complexes in a patient with secretory diarrhea. (3652900)
1987
38
Secretory diarrhea with protein-losing enteropathy, enterocolitis cystica superficialis, intestinal lymphangiectasia, and congenital hepatic fibrosis: a new syndrome. (3080572)
1986
39
Congenital Na+ diarrhea: a new type of secretory diarrhea. (3880821)
1985
40
Secretory diarrhea with islet cell hyperplasia and increased immunohistochemical reactivity to serotonin. (6095478)
1984
41
Congenital dysautonomia with secretory diarrhea. (6578316)
1983
42
Colonic transport of water and electrolytes in a patient with secretory diarrhea due to collagenous colitis. (6581038)
1983
43
Production of secretory diarrhea by intravenous infusion of vasoactive intestinal polypeptide. (6316136)
1983
44
Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. (6953312)
1982
45
The prophylaxis and therapy of secretory diarrhea. (7043125)
1982
46
Nitrogen balance during recovery from secretory diarrhea of cholera in children. (7270478)
1981
47
Biotin-responsive in vivo carboxylase deficiency in two siblings with secretory diarrhea receiving total parenteral nutrition. (6792336)
1981
48
Composition of the intestinal fluid and the functional jejunoileal junction in secretory diarrhea of cholera in children. (6768219)
1980
49
Effect of somatostatin infusion on jejunal water and electrolyte transport in a patient with secretory diarrhea due to malignant carcinoid syndrome. (7350058)
1980
50
Ileal chloride secretion as a cause of secretory diarrhea in a patient with primary intestinal tuberculosis. (422011)
1979

Genetic Variations for Secretory Diarrhea

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Expression for genes affiliated with Secretory Diarrhea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for genes affiliated with Secretory Diarrhea

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12EMD Millipore, 53Reactome, 29KEGG
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Pathways related to Secretory Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
NO-dependent CFTR activation (normal and CF)
9.9PRKG2, CFTR
29.3SLC9A3R2, CFTR, GCC2
3
CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
9.1KCNN4, KCNQ1, CFTR, SPINT2
4
Hide members
9.1SEC61A1, CFTR, KCNQ1
5
Hide members
8.9KCNN4, KCNQ1, PRKG2, SST, CFTR
6
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
8.8SLC9A3R2, CFTR, SHANK2, PRKG2, LPAR2
7
Regulation of degradation of wt-CFTR
8.7SEC61A1, CFTR, DERL1

Compounds for genes affiliated with Secretory Diarrhea

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Secretory Diarrhea according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1clofilium44 2811.1CFTR, KCNQ1
2chromanol 293b44 59 2812.1KCNQ1, CFTR
3niflumic acid44 28 1112.0KCNQ1, CFTR
4bicarbonate4410.0SLC9A3R2, PRKG2
5tolbutamide44 49 28 1113.0CFTR, SST
61-ethyl-2-benzimidazolinone449.9CFTR, KCNN4
7charybdotoxin44 2810.8KCNQ1, KCNN4
8chlorzoxazone44 28 1111.7CFTR, KCNN4
9diazoxide44 59 28 1112.7CFTR, SST
10isoproterenol44 1110.7CFTR, SST, KCNQ1
11clotrimazole44 28 11 2412.6CFTR, KCNQ1, KCNN4
12chloride449.3KCNN4, KCNQ1, CFTR

GO Terms for genes affiliated with Secretory Diarrhea

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16Gene Ontology
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Cellular components related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.5SLC9A3R2, CFTR, PRKG2
2early endosomeGO:0057699.0CFTR, DERL1, KCNQ1

Biological processes related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to cAMPGO:0713209.9CFTR, KCNQ1
2water transportGO:0068339.5CFTR, PDZD3
3protein targeting to GolgiGO:0000429.4GCC1, GCC2

Molecular functions related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.3SEC61A1, KCNQ1, GCC2, GCC1, PDZD3, FOXP3

Products for genes affiliated with Secretory Diarrhea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Secretory Diarrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet