MCID: SCR003
MIFTS: 38

Secretory Diarrhea malady

Gastrointestinal diseases category
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Summaries for Secretory Diarrhea

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. the most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards: Secretory Diarrhea is related to diarrhea and pancreatitis. An important gene associated with Secretory Diarrhea is SPINT2 (serine peptidase inhibitor, Kunitz type, 2), and among its related pathways are Cytokine production by Th17 cells in CF and CFTR dependent regulation of ion channels in Airway Epithelium norm and CF . The compounds diazoxide and clofilium have been mentioned in the context of this disorder. Affiliated tissues include colon, skin and bone, and related mouse phenotypes are digestive/alimentary and no phenotypic analysis.

Aliases & Classifications for Secretory Diarrhea

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8Disease Ontology, 10DISEASES, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

secretory diarrhea 8 10 62


External Ids:

Disease Ontology8 DOID:0050129

Related Diseases for Secretory Diarrhea

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to secretory diarrhea

Symptoms for Secretory Diarrhea

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Drugs & Therapeutics for Secretory Diarrhea

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Secretory Diarrhea

Search NIH Clinical Center for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

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Anatomical Context for Secretory Diarrhea

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33MalaCards
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MalaCards organs/tissues related to Secretory Diarrhea:

33
Colon, Skin, Bone, Bone marrow

Animal Models for Secretory Diarrhea or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Secretory Diarrhea:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1FOXP3, SST, CFTR, KCNQ1
2MP:00030128.8CFTR, SHANK2, SST, FOXP3
3MP:00028738.6KCNQ1, CFTR, LPAR2, SST, FOXP3
4MP:00053868.3FOXP3, SST, LPAR2, SHANK2, CFTR, KCNQ1
5MP:00053788.1KCNQ1, CFTR, SHANK2, LPAR2, SST, FOXP3

Publications for Secretory Diarrhea

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52PubMed
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Articles related to Secretory Diarrhea:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Crofelemer for the treatment of secretory diarrhea. (22149578)
2012
2
Crofelemer, a novel agent for treatment of secretory diarrhea. (20388859)
2010
3
Intractable secretory diarrhea in a Japanese boy with mitochondrial respiratory chain complex I deficiency. (18560889)
2009
4
Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. (18223372)
2008
5
We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors. (17435618)
2007
6
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. (16614995)
2006
7
Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. (15342979)
2004
8
Legionella micdadei infection presenting as severe secretory diarrhea and a solitary pulmonary mass. (15034849)
2004
9
Acute appendicitis presenting as secretory diarrhea. (12037768)
2002
10
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. (12464662)
2002
11
Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. (12044816)
2002
12
Role of the enteric nervous system in the pathophysiology of secretory diarrhea. (12041649)
2002
13
New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. (11830825)
2000
14
Secretory diarrhea. (10980977)
1999
15
Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. (9586761)
1998
16
Secretory diarrhea caused by ipecac poisoning. (9161961)
1997
17
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea. (9009126)
1997
18
Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. (8835903)
1996
19
Secretory diarrhea in children: newly recognized toxins and hormone-secreting tumors. (8614604)
1996
20
Reactive oxygen and nitrogen metabolites as mediators of secretory diarrhea. (7498670)
1995
21
A pharmacological approach to secretory diarrhea. (7743122)
1995
22
Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. (8385040)
1993
23
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea. (8492256)
1993
24
Sigmoid volvulus presenting as chronic secretory diarrhea responsive to octreotide. (1728114)
1992
25
The effect of nifedipine on secretory diarrhea in mice. (1440948)
1992
26
Secretory diarrhea following a dog bite. (1864208)
1991
27
Secretory diarrhea and candidal overgrowth: cause and effect? (1894948)
1991
28
Severe secretory diarrhea with elevated gastrin-releasing peptide controlled by somatostatin analogue: a case report. (1980089)
1990
29
The somatostatin analog octreotide in the management of the secretory diarrhea of the acute intestinal graft-versus-host disease in a patient after bone marrow transplantation. (2360261)
1990
30
Treatment of secretory diarrhea in AIDS with the somatostatin analogue SMS 201-995. (2724869)
1989
31
Secretory diarrhea in Crohn's disease with concurrent giardiasis. (2738361)
1989
32
Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. (2795459)
1989
33
Efficacy of oral rehydration solutions in a rat model of secretory diarrhea. (3430270)
1987
34
Secretory diarrhea and thyrotoxicosis. (3800200)
1987
35
Malabsorption of long-chain fatty acid in cholera toxin-induced secretory diarrhea. (3698768)
1986
36
Thyrotoxicosis presenting with secretory diarrhea. (3089089)
1986
37
Secretory diarrhea with protein-losing enteropathy, enterocolitis cystica superficialis, intestinal lymphangiectasia, and congenital hepatic fibrosis: a new syndrome. (3080572)
1986
38
Secretory diarrhea in mixed connective tissue disease. (3969997)
1985
39
Treatment of chronic secretory diarrhea of unknown origin by lithium carbonate. (6430744)
1984
40
Congenital dysautonomia with secretory diarrhea. (6578316)
1983
41
Colonic transport of water and electrolytes in a patient with secretory diarrhea due to collagenous colitis. (6581038)
1983
42
Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. (6953312)
1982
43
A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse. (7075417)
1982
44
Secretory diarrhea in ulcerative colitis. (7089632)
1982
45
Nitrogen balance during recovery from secretory diarrhea of cholera in children. (7270478)
1981
46
Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. (7227779)
1981
47
Composition of the intestinal fluid and the functional jejunoileal junction in secretory diarrhea of cholera in children. (6768219)
1980
48
Immunodeficiency, malabsorption and secretory diarrhea. A new syndrome. (474604)
1979
49
Ileal chloride secretion as a cause of secretory diarrhea in a patient with primary intestinal tuberculosis. (422011)
1979
50
Normal jejunal cyclic nucleotide content in a patient with secretory diarrhea. (210731)
1978

Variations for Secretory Diarrhea

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Expression for genes affiliated with Secretory Diarrhea

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for genes affiliated with Secretory Diarrhea

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50PathCards, 60Thomson Reuters, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Secretory Diarrhea

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45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB
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Compounds related to Secretory Diarrhea according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1diazoxide45 61 29 1113.1SST, CFTR
2clofilium45 2911.1CFTR, KCNQ1
3tolbutamide45 29 51 1113.1SST, CFTR
4chromanol 293b61 45 2912.0CFTR, KCNQ1
5niflumic acid45 29 1112.0CFTR, KCNQ1
6clotrimazole29 45 24 1113.0CFTR, KCNQ1
7lactose45 1110.9SST, CFTR
8pertussis459.8LPAR2, SST
9glibenclamide45 29 51 6112.8CFTR, KCNQ1
10isoproterenol45 1110.7KCNQ1, CFTR, SST
11vinblastine45 51 1111.7SST, CFTR
12epinephrine45 24 1111.7KCNQ1, CFTR, SST
13amiloride45 29 1111.7SLC9A3R2, CFTR
14pge2459.5CFTR, SST, FOXP3
15bicarbonate459.5SLC9A3R2, CFTR
16sodium45 249.8SLC9A3R2, CFTR, KCNQ1

GO Terms for genes affiliated with Secretory Diarrhea

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16Gene Ontology
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Cellular components related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163248.8SLC9A3R2, SHANK2, CFTR
2plasma membraneGO:0058867.4SLC9A3R2, GCC1, LPAR2, SHANK2, CFTR, KCNQ1

Biological processes related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lung developmentGO:0303249.8FOXP3, CFTR
2water transportGO:0068339.6PDZD3, CFTR
3cellular response to cAMPGO:0713209.5CFTR, KCNQ1
4protein targeting to GolgiGO:0000429.1GCC2, GCC1

Molecular functions related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1PDZ domain bindingGO:0301659.6LPAR2, CFTR
2protein bindingGO:0055155.8SLC9A3R2, KCNQ1, CFTR, SHANK2, LPAR2, FOXP3

Products for genes affiliated with Secretory Diarrhea

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  • Antibodies
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  • Antibodies

Sources for Secretory Diarrhea

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet