MCID: SCR003
MIFTS: 36

Secretory Diarrhea malady

Summaries for Secretory Diarrhea

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. the most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards: Secretory Diarrhea is related to cholera and cystic fibrosis. An important gene associated with Secretory Diarrhea is SST (somatostatin), and among its related pathways are NO-dependent CFTR activation (normal and CF) and Clathrin-dependent protein traffic. The compounds clofilium and chromanol 293b have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, small intestine and colon, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Secretory Diarrhea

Sources:
8Disease Ontology, 10DISEASES, 61UMLS
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Aliases & Descriptions:

secretory diarrhea 8 10 61


External Ids:

Disease Ontology8 DOID:0050129

Related Diseases for Secretory Diarrhea

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to secretory diarrhea

Clinical Features for Secretory Diarrhea

Drugs & Therapeutics for Secretory Diarrhea

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Secretory Diarrhea

Drug clinical trials:

Search ClinicalTrials for Secretory Diarrhea

Search NIH Clinical Center for Secretory Diarrhea

Search CenterWatch for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

Anatomical Context for Secretory Diarrhea

Sources:
33MalaCards
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MalaCards organs/tissues related to Secretory Diarrhea:

33
Bone marrow, Small intestine, Colon, Skin, Pancreatic islet

Animal Models for Secretory Diarrhea or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Secretory Diarrhea:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5FOXP3, KCNN4, KCNQ1, PRKG2, SST, CFTR
2MP:00053767.4KCNQ1, FOXP3, PRKG2, SST, CFTR, SLC9A3R2
3MP:00053787.4SEC61A1, KCNQ1, FOXP3, LPAR2, PRKG2, SHANK2

Publications for Secretory Diarrhea

Sources:
51PubMed
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Articles related to Secretory Diarrhea:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Crofelemer for the treatment of secretory diarrhea. (22149578)
2012
2
Crofelemer, a novel agent for treatment of secretory diarrhea. (20388859)
2010
3
Intractable secretory diarrhea in a Japanese boy with mitochondrial respiratory chain complex I deficiency. (18560889)
2009
4
We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors. (17435618)
2007
5
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. (16614995)
2006
6
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions. (16203867)
2005
7
Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. (16230079)
2005
8
Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. (15342979)
2004
9
Legionella micdadei infection presenting as severe secretory diarrhea and a solitary pulmonary mass. (15034849)
2004
10
Acute appendicitis presenting as secretory diarrhea. (12037768)
2002
11
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. (12464662)
2002
12
New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. (11830825)
2000
13
Continuous octreotide infusion for the treatment of secretory diarrhea caused by acute intestinal graft-versus-host disease in a child. (10959906)
2000
14
Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea. (10364049)
1999
15
Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. (9541283)
1998
16
Lansoprazole: a cause of secretory diarrhea. (9820425)
1998
17
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea. (9009126)
1997
18
Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. (8835903)
1996
19
Secretory diarrhea in children: newly recognized toxins and hormone-secreting tumors. (8614604)
1996
20
A pharmacological approach to secretory diarrhea. (7743122)
1995
21
Hexamethonium and secretory diarrhea. (7797038)
1995
22
Consensus statement: octreotide dose titration in secretory diarrhea. Diarrhea Management Consensus Development Panel. (7628270)
1995
23
Human intestinal cryptosporidiosis: secretory diarrhea and enterotoxic activity in Caco-2 cells. (7706827)
1995
24
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea. (8492256)
1993
25
Sigmoid volvulus presenting as chronic secretory diarrhea responsive to octreotide. (1728114)
1992
26
Control study of oral rehydration solution (ORS)/ORS + dioctahedral smectite in hospitalized Thai infants with acute secretory diarrhea. (1488694)
1992
27
Relation between small intestinal motor activity and transit in secretory diarrhea. (2399985)
1990
28
Severe secretory diarrhea with elevated gastrin-releasing peptide controlled by somatostatin analogue: a case report. (1980089)
1990
29
Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. (2214801)
1990
30
Alanine stimulation of water and sodium absorption in a model of secretory diarrhea. (2303972)
1990
31
Secretory diarrhea in Crohn's disease with concurrent giardiasis. (2738361)
1989
32
Characteristics and mechanism of action of a heat-stable enterotoxin produced by Klebsiella pneumoniae from infants with secretory diarrhea. (2470015)
1989
33
Successful treatment of idiopathic secretory diarrhea of infancy with the somatostatin analogue SMS 201-995. (2891583)
1988
34
Efficacy of oral rehydration solutions in a rat model of secretory diarrhea. (3430270)
1987
35
Secretory diarrhea and thyrotoxicosis. (3800200)
1987
36
Migrating action potential complexes in a patient with secretory diarrhea. (3652900)
1987
37
Malabsorption of long-chain fatty acid in cholera toxin-induced secretory diarrhea. (3698768)
1986
38
Thyrotoxicosis presenting with secretory diarrhea. (3089089)
1986
39
Secretory diarrhea with protein-losing enteropathy, enterocolitis cystica superficialis, intestinal lymphangiectasia, and congenital hepatic fibrosis: a new syndrome. (3080572)
1986
40
Intestinal barrier to intact horseradish peroxidase in experimental secretory diarrhea. (3723268)
1986
41
Secretory diarrhea in mixed connective tissue disease. (3969997)
1985
42
Secretory diarrhea with islet cell hyperplasia and increased immunohistochemical reactivity to serotonin. (6095478)
1984
43
Congenital dysautonomia with secretory diarrhea. (6578316)
1983
44
Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. (6953312)
1982
45
The prophylaxis and therapy of secretory diarrhea. (7043125)
1982
46
Nitrogen balance during recovery from secretory diarrhea of cholera in children. (7270478)
1981
47
Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. (7227779)
1981
48
Biotin-responsive in vivo carboxylase deficiency in two siblings with secretory diarrhea receiving total parenteral nutrition. (6792336)
1981
49
Composition of the intestinal fluid and the functional jejunoileal junction in secretory diarrhea of cholera in children. (6768219)
1980
50
Ileal chloride secretion as a cause of secretory diarrhea in a patient with primary intestinal tuberculosis. (422011)
1979

Genetic Variations for Secretory Diarrhea

Expression for genes affiliated with Secretory Diarrhea

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for genes affiliated with Secretory Diarrhea

Sources:
12EMD Millipore, 54Reactome, 30KEGG
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Pathways related to Secretory Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
NO-dependent CFTR activation (normal and CF)
9.9CFTR, PRKG2
29.3CFTR, GCC2, SLC9A3R2
3
CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
9.1SPINT2, CFTR, KCNN4, KCNQ1
4
Hide members
9.1KCNQ1, CFTR, SEC61A1
5
Hide members
8.9CFTR, KCNN4, KCNQ1, PRKG2, SST
6
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
8.8LPAR2, PRKG2, SHANK2, CFTR, SLC9A3R2
7
Regulation of degradation of wt-CFTR
8.7DERL1, CFTR, SEC61A1

Compounds for genes affiliated with Secretory Diarrhea

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Secretory Diarrhea according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1clofilium45 2911.1CFTR, KCNQ1
2chromanol 293b45 60 2912.1KCNQ1, CFTR
3niflumic acid45 29 1112.0KCNQ1, CFTR
4bicarbonate4510.0SLC9A3R2, PRKG2
5tolbutamide45 50 29 1113.0CFTR, SST
61-ethyl-2-benzimidazolinone459.9CFTR, KCNN4
7charybdotoxin45 2910.8KCNQ1, KCNN4
8chlorzoxazone45 29 1111.7CFTR, KCNN4
9diazoxide45 60 29 1112.7CFTR, SST
10isoproterenol45 1110.7CFTR, SST, KCNQ1
11clotrimazole45 29 11 2412.6CFTR, KCNQ1, KCNN4
12chloride459.3KCNN4, KCNQ1, CFTR

GO Terms for genes affiliated with Secretory Diarrhea

Sources:
16Gene Ontology
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Cellular components related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.5SLC9A3R2, CFTR, PRKG2
2early endosomeGO:0057699.0CFTR, DERL1, KCNQ1

Biological processes related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to cAMPGO:0713209.9CFTR, KCNQ1
2water transportGO:0068339.5CFTR, PDZD3
3protein targeting to GolgiGO:0000429.4GCC1, GCC2

Molecular functions related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.3SEC61A1, KCNQ1, GCC2, GCC1, PDZD3, FOXP3

Products for genes affiliated with Secretory Diarrhea

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Secretory Diarrhea

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet