Aliases & Classifications for Secretory Diarrhea

MalaCards integrated aliases for Secretory Diarrhea:

Name: Secretory Diarrhea 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050129

Summaries for Secretory Diarrhea

Disease Ontology : 12 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards based summary : Secretory Diarrhea is related to secretory diarrhea myopathy and deafness and immunodysregulation, polyendocrinopathy, and enteropathy, x-linked, and has symptoms including diarrhea and intermittent diarrhea. An important gene associated with Secretory Diarrhea is SLC9A3 (Solute Carrier Family 9 Member A3), and among its related pathways/superpathways are Regulation of CFTR activity (norm and CF) and Mineral absorption. The drugs Omeprazole and Ondansetron have been mentioned in the context of this disorder. Affiliated tissues include liver, prostate and colon, and related phenotypes are behavior/neurological and digestive/alimentary

Related Diseases for Secretory Diarrhea

Diseases related to Secretory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Related Disease Score Top Affiliating Genes
1 secretory diarrhea myopathy and deafness 12.0
2 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.8
3 villous adenoma 11.2
4 congenital chloride diarrhea 11.1
5 diarrhea 8, secretory sodium, congenital 11.1
6 diarrhea 3, secretory sodium, congenital, syndromic 11.1
7 diarrhea 1, secretory chloride, congenital 10.9
8 camurati-engelmann disease 10.6 SLC9A3 SPINT2
9 diarrhea 10.6
10 diarrhea 5, with tufting enteropathy, congenital 10.5 MYO5B SPINT2
11 lactose intolerance 10.3 CFTR SST
12 leprechaunism 10.2 MYO5B SLC9A3
13 wegmann jones smith syndrome 10.2 SST VIP
14 eec syndrome 10.2 MYO5B SLC9A3 SPINT2
15 intestinal volvulus 10.2 SST VIP
16 glutamate decarboxylase deficiency 10.2 SST VIP
17 spinal muscular atrophy 10.2 SST VIP
18 gastric gastrinoma 10.2 SST VIP
19 iris mixed cell melanoma 10.1 SST VIP
20 drug psychosis 10.1 SST VIP
21 encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 10.1 CFTR GUCY2C SLC9A3
22 bladder cancer, childhood 10.1 SST VIP
23 lung giant cell carcinoma 10.1 SST VIP
24 cholera 10.1
25 spinocerebellar ataxia 18 10.0 SLC26A3 SLC9A3
26 kartagener syndrome 10.0 SST VIP
27 inflammatory diarrhea 10.0 SLC26A3 SLC9A3
28 paralytic ileus 9.9 CFTR GUCY2C
29 spinal meningioma 9.9 FOXP3 VIP
30 sweat gland cancer 9.9 SST VIP
31 adenoma 9.9
32 crohn's disease 9.8
33 colonic pseudo-obstruction 9.8
34 colitis 9.8
35 cryptosporidiosis 9.6
36 ataxia 9.6
37 adenocarcinoma 9.6
38 dysautonomia 9.6
39 hepatitis 9.6
40 mixed connective tissue disease 9.6
41 paraneoplastic syndromes 9.6
42 systemic mastocytosis 9.6
43 ulcerative colitis 9.6
44 tuberculosis 9.6
45 ganglioneuroblastoma 9.6
46 myopathy 9.6
47 collagenous colitis 9.6
48 hypokalemia 9.6
49 jejunoileitis 9.6
50 pancreatitis 9.6

Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to Secretory Diarrhea

Symptoms & Phenotypes for Secretory Diarrhea

UMLS symptoms related to Secretory Diarrhea:


diarrhea, intermittent diarrhea

MGI Mouse Phenotypes related to Secretory Diarrhea:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 CFTR EMD FOXP3 GUCY2C SHANK2 SST
2 digestive/alimentary MP:0005381 9.7 SST CFTR FOXP3 GUCY2C MYO5B SLC26A3
3 homeostasis/metabolism MP:0005376 9.56 CFTR FOXP3 GUCY2C MYO5B SLC26A3 SLC9A3
4 mortality/aging MP:0010768 9.28 CFTR FOXP3 GUCY2C MYO5B SHANK2 SLC26A3

Drugs & Therapeutics for Secretory Diarrhea

Drugs for Secretory Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
2
Ondansetron Approved Phase 4 99614-02-5 4595
3 Anti-Anxiety Agents Phase 4
4 Antiemetics Phase 4
5 Antipruritics Phase 4
6 Antipsychotic Agents Phase 4
7 Autonomic Agents Phase 4
8 Central Nervous System Depressants Phase 4,Phase 2
9 Dermatologic Agents Phase 4
10 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Neurotransmitter Agents Phase 4
12 Peripheral Nervous System Agents Phase 4,Phase 2
13 Psychotropic Drugs Phase 4
14
Serotonin Phase 4 50-67-9 5202
15 Serotonin Agents Phase 4
16 Serotonin Antagonists Phase 4
17 Tranquilizing Agents Phase 4
18 Analgesics Phase 4,Phase 2
19 Analgesics, Non-Narcotic Phase 4
20 Anti-Inflammatory Agents Phase 4,Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 4
22 Antirheumatic Agents Phase 4
23 Mesalamine Phase 4 89-57-6
24
Zinc Approved Phase 2, Phase 3 7440-66-6 32051 23994
25 lanreotide Approved Phase 3 108736-35-2
26
Loperamide Approved Phase 3,Phase 2 53179-11-6 3955
27
Somatostatin Approved Phase 3 38916-34-6, 51110-01-1 53481605
28 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
29 Angiopeptin Phase 3
30 Antidiarrheals Phase 3,Phase 2
31 Hormone Antagonists Phase 3,Phase 2
32 Hormones Phase 3,Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
34 Acidophilus Nutraceutical Phase 3
35
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
36
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
37
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
38
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
39 Anti-Bacterial Agents Phase 2,Phase 1
40 Analgesics, Opioid Phase 2
41 Narcotic Antagonists Phase 2
42 Narcotics Phase 2
43 Vaccines Phase 1, Phase 2
44 Antimitotic Agents Phase 2
45 Antineoplastic Agents, Hormonal Phase 2
46 glucocorticoids Phase 2
47 taxane Phase 2
48 isoleucine Nutraceutical Phase 2
49
Aluminum hydroxide Approved Phase 1 21645-51-2
50
Aluminum sulfate Approved Phase 1 10043-01-3

Interventional clinical trials:

(show all 30)

id Name Status NCT ID Phase Drugs
1 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
2 Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D) Completed NCT00745004 Phase 4 Ondansetron;Placebo
3 Mesalazine for the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D) Completed NCT01316718 Phase 4 Mesalazine;Placebo
4 Oral Rehydration Solution With Zinc and Prebiotics in Acute Diarrhea Completed NCT01025583 Phase 2, Phase 3
5 Fermented Milk and Fermented Rice on the Appearance of Respiratory and Gastrointestinal Symptoms Completed NCT01909128 Phase 3
6 Evaluation of Lanreotide Efficacity in High Output Stoma: a Multicentric Randomized Study Recruiting NCT02354768 Phase 3 Effects of lanreotide with current anti-diarrheal treatments (diosmectite and loperamide);Effects of current anti-diarrheal treatments (diosmectite and loperamide) alone
7 Probiotics in Irritable Bowel Syndrome Withdrawn NCT00846170 Phase 3 co-biotic;placebo 2T/day
8 Isoleucine Added ORS in Children With Diarrhoea Completed NCT01034228 Phase 2
9 Efficacy of Benefiber-Added, Reduced-Osmolarity WHO-ORS in the Treatment of Cholera in Adults Completed NCT00672308 Phase 2
10 Quarfloxin in Patients With Low to Intermediate Grade Neuroendocrine Carcinoma Completed NCT00780663 Phase 2 Quarfloxin
11 Evaluation of the Efficacy and Safety of ADL5945 Once Daily for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer Pain Completed NCT01275755 Phase 2 Placebo;ADL5945 0.25 mg
12 Diarrhea Prophylaxis in Patients With HER2+ Breast Cancer Treated With Trastuzumab and Neratinib, Followed by Neratinib Monotherapy Recruiting NCT03094052 Phase 2 Neratinib;Trastuzumab;Crofelemer;Loperamide
13 Enterotoxigenic Escherichia Coli (ETEC) ETVAX Vaccine Trial in Bangladesh Recruiting NCT02531802 Phase 1, Phase 2
14 Ziv-Aflibercept for Advanced Progressive Carcinoid Tumors Recruiting NCT01782443 Phase 2 Ziv-aflibercept
15 Cabazitaxel Plus Prednisone With Octreotide For Castration-Resistant Prostate Cancer (CRPC) Previously Treated With Docetaxel Terminated NCT01469338 Phase 2 cabazitaxel;prednisone;octreotide pamoate;octreotide acetate
16 Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIa Terminated NCT00866476 Phase 2
17 Efficacy of iOWH032 in Dehydrating Cholera Withdrawn NCT02111304 Phase 2 iOWH032
18 Safety and Immunogenicity of CVD 1902 Oral Attenuated Vaccine to Prevent S. Paratyphi A Infection Completed NCT01129453 Phase 1
19 Phase I Study of ETEC Vaccine Completed NCT01147445 Phase 1
20 A Phase 1 Study of PV-10 Chemoablation of Neuroendocrine Tumours (NET) Metastatic to the Liver Recruiting NCT02693067 Phase 1 Rose bengal disodium
21 Safety Study of a Capsule-Conjugate Vaccine to Prevent Campylobacter-Caused Diarrhea Recruiting NCT02067676 Phase 1 Alhydrogel®, aluminum hydroxide adjuvant (alum)
22 Enteroaggregative E.Coli (EAEC) Terminated NCT00362869 Phase 1 Levofloxacin;Placebo
23 Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4 Completed NCT01406288
24 Effects of Lubiprostone on Gastrointestinal Transit & pH in Irritable Bowel Syndrome (IBS) With Constipation Completed NCT01162863 Lubiprostone;Placebo
25 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
26 Probiotics Against Pathogenic Bacteria in Advanced ENT-Surgery Recruiting NCT01730066
27 Effect of Different Concentrations of Xylitol and Erythritol on Gut Peptide Release and Gastric Emptying in Humans Recruiting NCT03039478
28 Serum-Derived Bovine Immunoglobulin /Protein Isolate (SBI) 5.0 g Bid on Nutritional Status in Subjects With IBS-D Active, not recruiting NCT02163213
29 Treatment of Latent Autoimmune Diabetes of the Adult Active, not recruiting NCT01140438 metformin+ NPH insulin;metformin + sitagliptin +/- repaglinide
30 Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult. Not yet recruiting NCT03166670

Search NIH Clinical Center for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

Anatomical Context for Secretory Diarrhea

MalaCards organs/tissues related to Secretory Diarrhea:

39
Liver, Prostate, Colon, Bone, Skin, Small Intestine, Bone Marrow

Publications for Secretory Diarrhea

Articles related to Secretory Diarrhea:

(show top 50) (show all 85)
id Title Authors Year
1
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. ( 28580600 )
2017
2
Pathogen-induced secretory diarrhea and its prevention. ( 27473379 )
2016
3
A case report of a giant rectal adenoma causing secretory diarrhea and acute renal failure: McKittrick-Wheelock syndrome. ( 27267899 )
2016
4
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. ( 26907621 )
2016
5
Drug-induced secretory diarrhea: A role for CFTR. ( 26429773 )
2015
6
Crofelemer: In Hiv Associated Diarrhea and Secretory Diarrhea- A Patent Perspective. ( 25851117 )
2015
7
Gut microbial succession follows acute secretory diarrhea in humans. ( 25991682 )
2015
8
Crofelemer for the treatment of secretory diarrhea. ( 22149578 )
2012
9
Crofelemer, a novel agent for treatment of secretory diarrhea. ( 20388859 )
2010
10
Intractable secretory diarrhea in a Japanese boy with mitochondrial respiratory chain complex I deficiency. ( 18560889 )
2009
11
Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. ( 18223372 )
2008
12
We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors. ( 17435618 )
2007
13
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. ( 16614995 )
2006
14
Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. ( 16230079 )
2005
15
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions. ( 16203867 )
2005
16
Legionella micdadei infection presenting as severe secretory diarrhea and a solitary pulmonary mass. ( 15034849 )
2004
17
Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. ( 15342979 )
2004
18
Congenital myopathy, recurrent secretory diarrhea, bullous eruption of skin, microcephaly, and deafness: a new genetic syndrome? ( 12476446 )
2003
19
Secretory diarrhea owing to a tape bezoar in a child with Hirschsprung's disease. ( 14614723 )
2003
20
Role of the enteric nervous system in the pathophysiology of secretory diarrhea. ( 12041649 )
2002
21
Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. ( 12044816 )
2002
22
Acute appendicitis presenting as secretory diarrhea. ( 12037768 )
2002
23
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. ( 12464662 )
2002
24
Continuous octreotide infusion for the treatment of secretory diarrhea caused by acute intestinal graft-versus-host disease in a child. ( 10959906 )
2000
25
New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. ( 11830825 )
2000
26
Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea. ( 10364049 )
1999
27
Secretory diarrhea. ( 10980977 )
1999
28
Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. ( 9541283 )
1998
29
Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. ( 9586761 )
1998
30
Lansoprazole: a cause of secretory diarrhea. ( 9820425 )
1998
31
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea. ( 9009126 )
1997
32
Secretory diarrhea caused by ipecac poisoning. ( 9161961 )
1997
33
Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. ( 8835903 )
1996
34
Secretory diarrhea in children: newly recognized toxins and hormone-secreting tumors. ( 8614604 )
1996
35
A pharmacological approach to secretory diarrhea. ( 7743122 )
1995
36
Human intestinal cryptosporidiosis: secretory diarrhea and enterotoxic activity in Caco-2 cells. ( 7706827 )
1995
37
Reactive oxygen and nitrogen metabolites as mediators of secretory diarrhea. ( 7498670 )
1995
38
Consensus statement: octreotide dose titration in secretory diarrhea. Diarrhea Management Consensus Development Panel. ( 7628270 )
1995
39
Hexamethonium and secretory diarrhea. ( 7797038 )
1995
40
Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. ( 8385040 )
1993
41
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea. ( 8492256 )
1993
42
Sigmoid volvulus presenting as chronic secretory diarrhea responsive to octreotide. ( 1728114 )
1992
43
Secretory diarrhea in villous adenoma of rectum: effect of treatment with somatostatin and indomethacin. ( 1410521 )
1992
44
The effect of nifedipine on secretory diarrhea in mice. ( 1440948 )
1992
45
Control study of oral rehydration solution (ORS)/ORS + dioctahedral smectite in hospitalized Thai infants with acute secretory diarrhea. ( 1488694 )
1992
46
Secretory diarrhea following a dog bite. ( 1864208 )
1991
47
Secretory diarrhea and candidal overgrowth: cause and effect? ( 1894948 )
1991
48
Congenital diabetes mellitus and fatal secretory diarrhea in two infants. ( 1779317 )
1991
49
Severe secretory diarrhea with elevated gastrin-releasing peptide controlled by somatostatin analogue: a case report. ( 1980089 )
1990
50
Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. ( 2214801 )
1990

Variations for Secretory Diarrhea

Expression for Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for Secretory Diarrhea

Pathways related to Secretory Diarrhea according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.02 CFTR MYO5B SHANK2
2 10.86 SLC26A3 SLC9A3
3 10.5 CFTR SPINT2

GO Terms for Secretory Diarrhea

Cellular components related to Secretory Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.26 CFTR SHANK2 SLC26A3 SLC9A3
2 brush border membrane GO:0031526 8.8 SHANK2 SLC26A3 SLC9A3

Biological processes related to Secretory Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to cAMP GO:0071320 9.37 CFTR SLC26A3
2 bicarbonate transport GO:0015701 9.32 CFTR SLC26A3
3 regulation of intracellular pH GO:0051453 9.26 SLC26A3 SLC9A3
4 sperm capacitation GO:0048240 9.16 CFTR SLC26A3
5 membrane hyperpolarization GO:0060081 8.96 CFTR SLC26A3
6 intracellular pH elevation GO:0051454 8.62 CFTR SLC26A3

Molecular functions related to Secretory Diarrhea according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 antiporter activity GO:0015297 9.16 SLC26A3 SLC9A3
2 bicarbonate transmembrane transporter activity GO:0015106 8.96 CFTR SLC26A3
3 chloride transmembrane transporter activity GO:0015108 8.62 CFTR SLC26A3

Sources for Secretory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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