MCID: SCR003
MIFTS: 36

Secretory Diarrhea malady

Summaries for Secretory Diarrhea

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. the most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards: Secretory Diarrhea is related to diarrhea and cholera. An important gene associated with Secretory Diarrhea is SST (somatostatin), and among its related pathways are NO-dependent CFTR activation (normal and CF) and Clathrin-dependent protein traffic. The compounds clofilium and chromanol 293b have been mentioned in the context of this disorder. Affiliated tissues include colon, skin and bone, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Aliases & Classifications for Secretory Diarrhea

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8Disease Ontology, 10DISEASES, 60UMLS
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Aliases & Descriptions:

secretory diarrhea 8 10 60


External Ids:

Disease Ontology8 DOID:0050129

Related Diseases for Secretory Diarrhea

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to secretory diarrhea

Clinical Features for Secretory Diarrhea

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Drugs & Therapeutics for Secretory Diarrhea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Secretory Diarrhea

Drug clinical trials:

Search ClinicalTrials for Secretory Diarrhea

Search NIH Clinical Center for Secretory Diarrhea

Search CenterWatch for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

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Anatomical Context for Secretory Diarrhea

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32MalaCards
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MalaCards organs/tissues related to Secretory Diarrhea:

32
Colon, Skin, Bone, Bone marrow, Small intestine

Animal Models for Secretory Diarrhea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Secretory Diarrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5CFTR, KCNN4, KCNQ1, FOXP3, PRKG2, SST
2MP:00053767.4KCNQ1, FOXP3, PRKG2, SST, CFTR, SLC9A3R2
3MP:00053787.4KCNQ1, FOXP3, LPAR2, PRKG2, SHANK2, SST

Publications for Secretory Diarrhea

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50PubMed
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Articles related to Secretory Diarrhea:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Crofelemer, a novel agent for treatment of secretory diarrhea. (20388859)
2010
2
Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. (18223372)
2008
3
Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. (16230079)
2005
4
Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. (15097437)
2004
5
Secretory diarrhea owing to a tape bezoar in a child with Hirschsprung's disease. (14614723)
2003
6
Congenital myopathy, recurrent secretory diarrhea, bullous eruption of skin, microcephaly, and deafness: a new genetic syndrome? (12476446)
2003
7
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. (12464662)
2002
8
Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. (12044816)
2002
9
Role of the enteric nervous system in the pathophysiology of secretory diarrhea. (12041649)
2002
10
New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. (11830825)
2000
11
Continuous octreotide infusion for the treatment of secretory diarrhea caused by acute intestinal graft-versus-host disease in a child. (10959906)
2000
12
Secretory diarrhea. (10980977)
1999
13
Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea. (10364049)
1999
14
Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. (9586761)
1998
15
Lansoprazole: a cause of secretory diarrhea. (9820425)
1998
16
Secretory diarrhea caused by ipecac poisoning. (9161961)
1997
17
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea. (9009126)
1997
18
Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. (8835903)
1996
19
Reactive oxygen and nitrogen metabolites as mediators of secretory diarrhea. (7498670)
1995
20
Hexamethonium and secretory diarrhea. (7797038)
1995
21
Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. (8385040)
1993
22
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea. (8492256)
1993
23
The effect of nifedipine on secretory diarrhea in mice. (1440948)
1992
24
Control study of oral rehydration solution (ORS)/ORS + dioctahedral smectite in hospitalized Thai infants with acute secretory diarrhea. (1488694)
1992
25
Secretory diarrhea in villous adenoma of rectum: effect of treatment with somatostatin and indomethacin. (1410521)
1992
26
Secretory diarrhea following a dog bite. (1864208)
1991
27
Secretory diarrhea and candidal overgrowth: cause and effect? (1894948)
1991
28
Congenital diabetes mellitus and fatal secretory diarrhea in two infants. (1779317)
1991
29
Relation between small intestinal motor activity and transit in secretory diarrhea. (2399985)
1990
30
The somatostatin analog octreotide in the management of the secretory diarrhea of the acute intestinal graft-versus-host disease in a patient after bone marrow transplantation. (2360261)
1990
31
Treatment of secretory diarrhea in AIDS with the somatostatin analogue SMS 201-995. (2724869)
1989
32
Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. (2795459)
1989
33
Secretory diarrhea and thyrotoxicosis. (3800200)
1987
34
Malabsorption of long-chain fatty acid in cholera toxin-induced secretory diarrhea. (3698768)
1986
35
Thyrotoxicosis presenting with secretory diarrhea. (3089089)
1986
36
Intestinal barrier to intact horseradish peroxidase in experimental secretory diarrhea. (3723268)
1986
37
Secretory diarrhea in mixed connective tissue disease. (3969997)
1985
38
Congenital Na+ diarrhea: a new type of secretory diarrhea. (3880821)
1985
39
Treatment of chronic secretory diarrhea of unknown origin by lithium carbonate. (6430744)
1984
40
Congenital dysautonomia with secretory diarrhea. (6578316)
1983
41
Colonic transport of water and electrolytes in a patient with secretory diarrhea due to collagenous colitis. (6581038)
1983
42
Production of secretory diarrhea by intravenous infusion of vasoactive intestinal polypeptide. (6316136)
1983
43
A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse. (7075417)
1982
44
Secretory diarrhea in ulcerative colitis. (7089632)
1982
45
Nitrogen balance during recovery from secretory diarrhea of cholera in children. (7270478)
1981
46
Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. (7227779)
1981
47
Trifluoperazine reversal of secretory diarrhea in pancreatic cholera. (6250437)
1980
48
Effect of somatostatin infusion on jejunal water and electrolyte transport in a patient with secretory diarrhea due to malignant carcinoid syndrome. (7350058)
1980
49
Immunodeficiency, malabsorption and secretory diarrhea. A new syndrome. (474604)
1979
50
Normal jejunal cyclic nucleotide content in a patient with secretory diarrhea. (210731)
1978

Genetic Variations for Secretory Diarrhea

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Expression for genes affiliated with Secretory Diarrhea

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for genes affiliated with Secretory Diarrhea

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12EMD Millipore, 53Reactome, 29KEGG
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Pathways related to Secretory Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
NO-dependent CFTR activation (normal and CF)
9.9PRKG2, CFTR
29.3SLC9A3R2, CFTR, GCC2
3
CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
9.1KCNN4, KCNQ1, CFTR, SPINT2
4
Hide members
9.1SEC61A1, CFTR, KCNQ1
5
Hide members
8.9KCNN4, KCNQ1, PRKG2, SST, CFTR
6
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
8.8SLC9A3R2, CFTR, SHANK2, PRKG2, LPAR2
7
Regulation of degradation of wt-CFTR
8.7SEC61A1, CFTR, DERL1

Compounds for genes affiliated with Secretory Diarrhea

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Secretory Diarrhea according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1clofilium44 2811.1CFTR, KCNQ1
2chromanol 293b44 59 2812.1KCNQ1, CFTR
3niflumic acid44 28 1112.0KCNQ1, CFTR
4bicarbonate4410.0SLC9A3R2, PRKG2
5tolbutamide44 49 28 1113.0CFTR, SST
61-ethyl-2-benzimidazolinone449.9CFTR, KCNN4
7charybdotoxin44 2810.8KCNQ1, KCNN4
8chlorzoxazone44 28 1111.7CFTR, KCNN4
9diazoxide44 59 28 1112.7CFTR, SST
10isoproterenol44 1110.7CFTR, SST, KCNQ1
11clotrimazole44 28 11 2412.6CFTR, KCNQ1, KCNN4
12chloride449.3KCNN4, KCNQ1, CFTR

GO Terms for genes affiliated with Secretory Diarrhea

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16Gene Ontology
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Cellular components related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.5SLC9A3R2, CFTR, PRKG2
2early endosomeGO:0057699.0CFTR, DERL1, KCNQ1

Biological processes related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to cAMPGO:0713209.9CFTR, KCNQ1
2water transportGO:0068339.5CFTR, PDZD3
3protein targeting to GolgiGO:0000429.4GCC1, GCC2

Molecular functions related to Secretory Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055155.3SEC61A1, KCNQ1, GCC2, GCC1, PDZD3, FOXP3

Products for genes affiliated with Secretory Diarrhea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Secretory Diarrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet