MCID: SCR003
MIFTS: 36

Secretory Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Secretory Diarrhea

MalaCards integrated aliases for Secretory Diarrhea:

Name: Secretory Diarrhea 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050129
UMLS 69 C0267557

Summaries for Secretory Diarrhea

Disease Ontology : 12 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards based summary : Secretory Diarrhea is related to diarrhea 8, secretory sodium, congenital and diarrhea 1, secretory chloride, congenital, and has symptoms including intermittent diarrhea and diarrhea. An important gene associated with Secretory Diarrhea is SLC9A3 (Solute Carrier Family 9 Member A3), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Salivary secretion. Affiliated tissues include colon, skin and small intestine, and related phenotypes are behavior/neurological and digestive/alimentary

Related Diseases for Secretory Diarrhea

Diseases related to Secretory Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 diarrhea 8, secretory sodium, congenital 33.3 SLC9A3 SPINT2
2 diarrhea 1, secretory chloride, congenital 31.5 SLC26A3 SLC9A3
3 pancreatic cholera 29.7 SST VIP
4 cryptosporidiosis 29.7 SST VIP
5 diarrhea 29.0 FOXP3 GUCY2C MYO5B SLC26A3 SLC9A3 SPINT2
6 cystic fibrosis 28.9 CFTR GUCY2C SLC9A3 VIP
7 secretory diarrhea, myopathy, and deafness 12.1
8 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 12.0
9 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.7
10 villous adenoma 11.3
11 diarrhea 5, with tufting enteropathy, congenital 10.3 MYO5B SPINT2
12 steatorrhea 10.2 CFTR SST
13 cholera 10.1
14 wdha syndrome 10.1 SST VIP
15 congenital diarrhea 10.1 MYO5B SLC9A3 SPINT2
16 postgastrectomy syndrome 10.1 SST VIP
17 glucagonoma 10.1 SST VIP
18 vipoma 10.1 SST VIP
19 somatostatinoma 10.1 SST VIP
20 binswanger's disease 10.0 SST VIP
21 meconium ileus 10.0 CFTR GUCY2C SLC9A3
22 intestinal obstruction 10.0 CFTR GUCY2C
23 gastrinoma 10.0 SST VIP
24 islet cell tumor 10.0 SST VIP
25 megacolon 10.0 FOXP3 VIP
26 adenoma 10.0
27 osmotic diarrhea 9.9 SLC26A3 SLC9A3
28 constipation 9.9 SST VIP
29 fibrosis of extraocular muscles, congenital, 1 9.9
30 graves disease 1 9.9
31 graft-versus-host disease 9.9
32 crohn's disease 9.9
33 colitis 9.9
34 colonic pseudo-obstruction 9.9
35 gallbladder disease 9.8 CFTR SST
36 hyperprolactinemia 9.8 SST VIP
37 diarrhea 2, with microvillus atrophy 9.7 MYO5B SLC26A3 SLC9A3
38 enterocolitis 9.7
39 myopathy, congenital 9.7
40 ataxia and polyneuropathy, adult-onset 9.7
41 branchiootic syndrome 1 9.7
42 mycobacterium tuberculosis 1 9.7
43 autoinflammation with infantile enterocolitis 9.7
44 diabetes mellitus 9.7
45 hepatitis 9.7
46 systemic mastocytosis 9.7
47 ulcerative colitis 9.7
48 collagenous colitis 9.7
49 jejunoileitis 9.7
50 protein-losing enteropathy 9.7

Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to Secretory Diarrhea

Symptoms & Phenotypes for Secretory Diarrhea

UMLS symptoms related to Secretory Diarrhea:


intermittent diarrhea, diarrhea

MGI Mouse Phenotypes related to Secretory Diarrhea:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 SLC9A4 CFTR SST EMD VIP FOXP3
2 digestive/alimentary MP:0005381 9.86 MYO5B SLC26A3 SLC9A3 SLC9A4 CFTR SST
3 homeostasis/metabolism MP:0005376 9.65 MYO5B SLC26A3 SLC9A3 SLC9A4 CFTR SST
4 endocrine/exocrine gland MP:0005379 9.63 SLC26A3 SLC9A3 SLC9A4 CFTR VIP FOXP3
5 mortality/aging MP:0010768 9.23 MYO5B SLC26A3 SPINT2 CFTR SST VIP

Drugs & Therapeutics for Secretory Diarrhea

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of iOWH032 in Dehydrating Cholera Withdrawn NCT02111304 Phase 2 iOWH032
2 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
3 Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult. Not yet recruiting NCT03166670

Search NIH Clinical Center for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

Anatomical Context for Secretory Diarrhea

MalaCards organs/tissues related to Secretory Diarrhea:

38
Colon, Skin, Small Intestine, Bone, Bone Marrow

Publications for Secretory Diarrhea

Articles related to Secretory Diarrhea:

(show top 50) (show all 85)
# Title Authors Year
1
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. ( 28580600 )
2017
2
A case report of a giant rectal adenoma causing secretory diarrhea and acute renal failure: McKittrick-Wheelock syndrome. ( 27267899 )
2016
3
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. ( 26907621 )
2016
4
Pathogen-induced secretory diarrhea and its prevention. ( 27473379 )
2016
5
Drug-induced secretory diarrhea: A role for CFTR. ( 26429773 )
2015
6
Gut microbial succession follows acute secretory diarrhea in humans. ( 25991682 )
2015
7
Crofelemer: In Hiv Associated Diarrhea and Secretory Diarrhea- A Patent Perspective. ( 25851117 )
2015
8
Crofelemer for the treatment of secretory diarrhea. ( 22149578 )
2012
9
Crofelemer, a novel agent for treatment of secretory diarrhea. ( 20388859 )
2010
10
Intractable secretory diarrhea in a Japanese boy with mitochondrial respiratory chain complex I deficiency. ( 18560889 )
2009
11
Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. ( 18223372 )
2008
12
We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors. ( 17435618 )
2007
13
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. ( 16614995 )
2006
14
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions. ( 16203867 )
2005
15
Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. ( 16230079 )
2005
16
Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. ( 15342979 )
2004
17
Legionella micdadei infection presenting as severe secretory diarrhea and a solitary pulmonary mass. ( 15034849 )
2004
18
Secretory diarrhea owing to a tape bezoar in a child with Hirschsprung's disease. ( 14614723 )
2003
19
Congenital myopathy, recurrent secretory diarrhea, bullous eruption of skin, microcephaly, and deafness: a new genetic syndrome? ( 12476446 )
2003
20
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. ( 12464662 )
2002
21
Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. ( 12044816 )
2002
22
Acute appendicitis presenting as secretory diarrhea. ( 12037768 )
2002
23
Role of the enteric nervous system in the pathophysiology of secretory diarrhea. ( 12041649 )
2002
24
Continuous octreotide infusion for the treatment of secretory diarrhea caused by acute intestinal graft-versus-host disease in a child. ( 10959906 )
2000
25
New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. ( 11830825 )
2000
26
Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea. ( 10364049 )
1999
27
Secretory diarrhea. ( 10980977 )
1999
28
Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. ( 9586761 )
1998
29
Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. ( 9541283 )
1998
30
Lansoprazole: a cause of secretory diarrhea. ( 9820425 )
1998
31
Secretory diarrhea caused by ipecac poisoning. ( 9161961 )
1997
32
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea. ( 9009126 )
1997
33
Secretory diarrhea in children: newly recognized toxins and hormone-secreting tumors. ( 8614604 )
1996
34
Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. ( 8835903 )
1996
35
Reactive oxygen and nitrogen metabolites as mediators of secretory diarrhea. ( 7498670 )
1995
36
A pharmacological approach to secretory diarrhea. ( 7743122 )
1995
37
Consensus statement: octreotide dose titration in secretory diarrhea. Diarrhea Management Consensus Development Panel. ( 7628270 )
1995
38
Human intestinal cryptosporidiosis: secretory diarrhea and enterotoxic activity in Caco-2 cells. ( 7706827 )
1995
39
Hexamethonium and secretory diarrhea. ( 7797038 )
1995
40
Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. ( 8385040 )
1993
41
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea. ( 8492256 )
1993
42
The effect of nifedipine on secretory diarrhea in mice. ( 1440948 )
1992
43
Sigmoid volvulus presenting as chronic secretory diarrhea responsive to octreotide. ( 1728114 )
1992
44
Control study of oral rehydration solution (ORS)/ORS + dioctahedral smectite in hospitalized Thai infants with acute secretory diarrhea. ( 1488694 )
1992
45
Secretory diarrhea in villous adenoma of rectum: effect of treatment with somatostatin and indomethacin. ( 1410521 )
1992
46
Congenital diabetes mellitus and fatal secretory diarrhea in two infants. ( 1779317 )
1991
47
Secretory diarrhea and candidal overgrowth: cause and effect? ( 1894948 )
1991
48
Secretory diarrhea following a dog bite. ( 1864208 )
1991
49
Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. ( 2214801 )
1990
50
The somatostatin analog octreotide in the management of the secretory diarrhea of the acute intestinal graft-versus-host disease in a patient after bone marrow transplantation. ( 2360261 )
1990

Variations for Secretory Diarrhea

Expression for Secretory Diarrhea

Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for Secretory Diarrhea

GO Terms for Secretory Diarrhea

Cellular components related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brush border membrane GO:0031526 8.96 SLC26A3 SLC9A3
2 apical plasma membrane GO:0016324 8.92 CFTR SLC26A3 SLC9A3 SLC9A4

Biological processes related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.73 CFTR SLC26A3 SLC9A3 SLC9A4
2 transmembrane transport GO:0055085 9.71 CFTR SLC26A3 SLC9A3 SLC9A4
3 cellular response to cAMP GO:0071320 9.48 CFTR SLC26A3
4 bicarbonate transport GO:0015701 9.46 CFTR SLC26A3
5 sperm capacitation GO:0048240 9.37 CFTR SLC26A3
6 regulation of pH GO:0006885 9.32 SLC9A3 SLC9A4
7 sodium ion import across plasma membrane GO:0098719 9.26 SLC9A3 SLC9A4
8 membrane hyperpolarization GO:0060081 9.16 CFTR SLC26A3
9 intracellular pH elevation GO:0051454 8.96 CFTR SLC26A3
10 regulation of intracellular pH GO:0051453 8.8 SLC26A3 SLC9A3 SLC9A4

Molecular functions related to Secretory Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bicarbonate transmembrane transporter activity GO:0015106 9.37 CFTR SLC26A3
2 solute:proton antiporter activity GO:0015299 9.32 SLC9A3 SLC9A4
3 sodium:proton antiporter activity GO:0015385 9.26 SLC9A3 SLC9A4
4 potassium:proton antiporter activity GO:0015386 9.16 SLC9A3 SLC9A4
5 chloride transmembrane transporter activity GO:0015108 8.96 CFTR SLC26A3
6 antiporter activity GO:0015297 8.8 SLC26A3 SLC9A3 SLC9A4

Sources for Secretory Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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