Aliases & Classifications for Secretory Diarrhea

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Secretory Diarrhea, Aliases & Descriptions:

Name: Secretory Diarrhea 9 11 60


External Ids:

Disease Ontology9 DOID:0050129

Summaries for Secretory Diarrhea

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Disease Ontology:9 Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. the most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions.

MalaCards based summary: Secretory Diarrhea is related to diarrhea and pancreatitis. An important gene associated with Secretory Diarrhea is SPINT2 (serine peptidase inhibitor, Kunitz type, 2), and among its related pathways are Cytokine production by Th17 cells in CF and CFTR dependent regulation of ion channels in Airway Epithelium norm and CF . The compounds diazoxide and clofilium have been mentioned in the context of this disorder. Affiliated tissues include colon, bone marrow and bone, and related mouse phenotypes are digestive/alimentary and no phenotypic analysis.

Related Diseases for Secretory Diarrhea

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Graphical network of the top 20 diseases related to Secretory Diarrhea:



Diseases related to secretory diarrhea

Symptoms for Secretory Diarrhea

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Drugs & Therapeutics for Secretory Diarrhea

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Drug clinical trials:

Search ClinicalTrials for Secretory Diarrhea

Search NIH Clinical Center for Secretory Diarrhea

Genetic Tests for Secretory Diarrhea

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Anatomical Context for Secretory Diarrhea

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MalaCards organs/tissues related to Secretory Diarrhea:

31
Colon, Bone marrow, Bone, Small intestine, Skin

Animal Models for Secretory Diarrhea or affiliated genes

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MGI Mouse Phenotypes related to Secretory Diarrhea:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1FOXP3, SST, CFTR, KCNQ1
2MP:00030128.8SHANK2, SST, FOXP3, CFTR
3MP:00028738.6FOXP3, CFTR, KCNQ1, LPAR2, SST
4MP:00053868.3FOXP3, KCNQ1, CFTR, SHANK2, LPAR2, SST
5MP:00053788.1FOXP3, SHANK2, KCNQ1, CFTR, SST, LPAR2

Publications for Secretory Diarrhea

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Articles related to Secretory Diarrhea:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Crofelemer: In Hiv Associated Diarrhea and Secretory Diarrhea- A Patent Perspective. (25851117)
2015
2
Crofelemer for the treatment of secretory diarrhea. (22149578)
2012
3
Crofelemer, a novel agent for treatment of secretory diarrhea. (20388859)
2010
4
Intractable secretory diarrhea in a Japanese boy with mitochondrial respiratory chain complex I deficiency. (18560889)
2009
5
Oral delivery of L-arginine stimulates prostaglandin-dependent secretory diarrhea in Cryptosporidium parvum-infected neonatal piglets. (18223372)
2008
6
We may be able to stop common lethal secretory diarrhea by activating the intestinal calcium sensing receptors. (17435618)
2007
7
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. (16614995)
2006
8
Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. (15342979)
2004
9
Legionella micdadei infection presenting as severe secretory diarrhea and a solitary pulmonary mass. (15034849)
2004
10
Acute appendicitis presenting as secretory diarrhea. (12037768)
2002
11
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. (12464662)
2002
12
Effects of an alanyl-glutamine-based oral rehydration and nutrition therapy solution on electrolyte and water absorption in a rat model of secretory diarrhea induced by cholera toxin. (12044816)
2002
13
Role of the enteric nervous system in the pathophysiology of secretory diarrhea. (12041649)
2002
14
New insights into the pathogenesis of intestinal dysfunction: secretory diarrhea and cystic fibrosis. (11830825)
2000
15
Secretory diarrhea. (10980977)
1999
16
Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. (9586761)
1998
17
Secretory diarrhea caused by ipecac poisoning. (9161961)
1997
18
Massive secretory diarrhea and pseudo-obstruction as the initial presentation of Crohn's disease. (8835903)
1996
19
Secretory diarrhea in children: newly recognized toxins and hormone-secreting tumors. (8614604)
1996
20
Reactive oxygen and nitrogen metabolites as mediators of secretory diarrhea. (7498670)
1995
21
A pharmacological approach to secretory diarrhea. (7743122)
1995
22
Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. (8385040)
1993
23
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea. (8492256)
1993
24
Sigmoid volvulus presenting as chronic secretory diarrhea responsive to octreotide. (1728114)
1992
25
The effect of nifedipine on secretory diarrhea in mice. (1440948)
1992
26
Secretory diarrhea following a dog bite. (1864208)
1991
27
Secretory diarrhea and candidal overgrowth: cause and effect? (1894948)
1991
28
Relation between small intestinal motor activity and transit in secretory diarrhea. (2399985)
1990
29
Severe secretory diarrhea with elevated gastrin-releasing peptide controlled by somatostatin analogue: a case report. (1980089)
1990
30
The somatostatin analog octreotide in the management of the secretory diarrhea of the acute intestinal graft-versus-host disease in a patient after bone marrow transplantation. (2360261)
1990
31
Treatment of secretory diarrhea in AIDS with the somatostatin analogue SMS 201-995. (2724869)
1989
32
Secretory diarrhea in Crohn's disease with concurrent giardiasis. (2738361)
1989
33
Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. (2795459)
1989
34
Efficacy of oral rehydration solutions in a rat model of secretory diarrhea. (3430270)
1987
35
Secretory diarrhea and thyrotoxicosis. (3800200)
1987
36
Malabsorption of long-chain fatty acid in cholera toxin-induced secretory diarrhea. (3698768)
1986
37
Thyrotoxicosis presenting with secretory diarrhea. (3089089)
1986
38
Secretory diarrhea with protein-losing enteropathy, enterocolitis cystica superficialis, intestinal lymphangiectasia, and congenital hepatic fibrosis: a new syndrome. (3080572)
1986
39
Secretory diarrhea in mixed connective tissue disease. (3969997)
1985
40
Treatment of chronic secretory diarrhea of unknown origin by lithium carbonate. (6430744)
1984
41
Congenital dysautonomia with secretory diarrhea. (6578316)
1983
42
Colonic transport of water and electrolytes in a patient with secretory diarrhea due to collagenous colitis. (6581038)
1983
43
Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis. (6953312)
1982
44
A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse. (7075417)
1982
45
Secretory diarrhea in ulcerative colitis. (7089632)
1982
46
Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. (7227779)
1981
47
Composition of the intestinal fluid and the functional jejunoileal junction in secretory diarrhea of cholera in children. (6768219)
1980
48
Immunodeficiency, malabsorption and secretory diarrhea. A new syndrome. (474604)
1979
49
Ileal chloride secretion as a cause of secretory diarrhea in a patient with primary intestinal tuberculosis. (422011)
1979
50
Normal jejunal cyclic nucleotide content in a patient with secretory diarrhea. (210731)
1978

Variations for Secretory Diarrhea

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Expression for genes affiliated with Secretory Diarrhea

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Search GEO for disease gene expression data for Secretory Diarrhea.

Pathways for genes affiliated with Secretory Diarrhea

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Compounds for genes affiliated with Secretory Diarrhea

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Compounds related to Secretory Diarrhea according to GeneCards Suite gene sharing:

(show all 16)
idCompoundScoreTop Affiliating Genes
1diazoxide43 59 28 1213.1SST, CFTR
2clofilium43 2811.1CFTR, KCNQ1
3tolbutamide43 28 49 1213.1SST, CFTR
4chromanol 293b59 43 2812.0CFTR, KCNQ1
5niflumic acid43 28 1212.0CFTR, KCNQ1
6clotrimazole28 43 24 1213.0CFTR, KCNQ1
7lactose43 1210.9SST, CFTR
8pertussis439.8LPAR2, SST
9glibenclamide43 28 49 5912.8CFTR, KCNQ1
10isoproterenol43 1210.7KCNQ1, CFTR, SST
11vinblastine43 49 1211.7SST, CFTR
12epinephrine43 24 1211.7KCNQ1, CFTR, SST
13amiloride43 28 1211.7SLC9A3R2, CFTR
14pge2439.5CFTR, SST, FOXP3
15bicarbonate439.5SLC9A3R2, CFTR
16sodium43 249.8SLC9A3R2, CFTR, KCNQ1

GO Terms for genes affiliated with Secretory Diarrhea

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Cellular components related to Secretory Diarrhea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163248.8SLC9A3R2, SHANK2, CFTR
2plasma membraneGO:00058867.4SLC9A3R2, GCC1, LPAR2, SHANK2, CFTR, KCNQ1

Biological processes related to Secretory Diarrhea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lung developmentGO:00303249.8FOXP3, CFTR
2water transportGO:00068339.6PDZD3, CFTR
3cellular response to cAMPGO:00713209.5CFTR, KCNQ1
4protein targeting to GolgiGO:00000429.1GCC2, GCC1

Molecular functions related to Secretory Diarrhea according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1PDZ domain bindingGO:00301659.6LPAR2, CFTR
2protein bindingGO:00055155.8SLC9A3R2, KCNQ1, CFTR, SHANK2, LPAR2, FOXP3

Products for genes affiliated with Secretory Diarrhea

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  • Antibodies
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Sources for Secretory Diarrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet