MCID: SZR006
MIFTS: 51

Seizure Disorder malady

Genetic diseases (common) category
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Summaries for Seizure Disorder

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NINDS:43 The epilepsies are a spectrum of brain disorders ranging from severe, life-threatening and disabling, to ones that are much more benign. In epilepsy, the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior or sometimes convulsions, muscle spasms, and loss of consciousness. The epilepsies have many possible causes and there are several types of seizures. Anything that disturbs the normal pattern of neuron activity?from illness to brain damage to abnormal brain development?can lead to seizures. Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters, changes in important features of brain cells called channels, or some combination of these and other factors. Having a single seizure as the result of a high fever (called febrile seizure) or head injury does not necessarily mean that a person has epilepsy. Only when a person has had two or more seizures is he or she considered to have epilepsy. A measurement of electrical activity in the brain and brain scans such as magnetic resonance imaging or computed tomography are common diagnostic tests for epilepsy.

MalaCards based summary: Seizure Disorder, also known as seizures, is related to febrile seizures and epilepsy syndrome. An important gene associated with Seizure Disorder is SEZ6L2 (seizure related 6 homolog (mouse)-like 2), and among its related pathways are G-Beta Gamma Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs primidone and anti-epileptic agent [epc] and the compounds acipimox and bc-iii have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related mouse phenotypes are normal and nervous system.

MedlinePlus:33 Seizures are symptoms of a brain problem. they happen because of sudden, abnormal electrical activity in the brain. when people think of seizures, they often think of convulsions in which a person's body shakes rapidly and uncontrollably. not all seizures cause convulsions. there are many types of seizures and some have mild symptoms. seizures fall into two main groups. focal seizures, also called partial seizures, happen in just one part of the brain. generalized seizures are a result of abnormal activity on both sides of the brain. most seizures last from 30 seconds to 2 minutes and do not cause lasting harm. however, it is a medical emergency if seizures last longer than 5 minutes or if a person has many seizures and does not wake up between them. seizures can have many causes, including medicines, high fevers, head injuries and certain diseases. people who have recurring seizures due to a brain disorder have epilepsy. nih: national institute of neurological disorders and stroke

Wikipedia:65 Epilepsy (from the Ancient Greek verb ???????????? meaning \"to seize, possess, or afflict\") is a group... more...

Aliases & Classifications for Seizure Disorder

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Seizure Disorder, Aliases & Descriptions:

Name: Seizure Disorder 43 62
 
Seizures 33


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Seizure Disorder

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Diseases in the Seizure Disorder family:

Scn1a-Related Seizure Disorders

Diseases related to Seizure Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1390)
idRelated DiseaseScoreTop Affiliating Genes
1febrile seizures31.5KCNQ2, SCN1B, SCN1A
2epilepsy syndrome31.1SCN2A
3dravet syndrome30.8SCN1A, SCN1B
4idiopathic generalized epilepsy30.7KCNQ2, SCN1A
5frontal lobe epilepsy30.7SCN1B, SCN1A, KCNQ2
6scn1a-related seizure disorders30.6SCN1A
7convulsions benign familial neonatal dominant form30.5KCNQ2, SCN1A, SCN1B
8mental retardation30.4CDKL5, VIP, KCNQ2
9early myoclonic encephalopathy30.1SCN1B, SCN1A
10brain disease29.8SCN1A, POLG, CDKL5, PNPO
11cerebrovascular disease29.2VIP, GHRL, HMGCR
12audiogenic seizures11.0
13generalized epilepsy with febrile seizures plus10.5
14status epilepticus10.5
15juvenile myoclonic epilepsy10.5
16focal epilepsy10.5
17lennox-gastaut syndrome10.5
18pyridoxine-dependent epilepsy10.4
19tuberous sclerosis10.4
20kifafa seizure disorder10.3
21malignant migrating partial seizures of infancy10.3
22reflex epilepsy10.3
23tuberous sclerosis complex10.3
24ataxia10.3
25childhood absence epilepsy10.3
26ischemia10.3
27rett syndrome10.3
28migraine10.3
29benign familial neonatal-infantile seizures10.3
30ganglioglioma10.3
31limbic encephalitis10.3
32acute encephalopathy with biphasic seizures and late reduced diffusion10.3
33insulinoma10.3
34retrograde amnesia10.2
35microcephaly, seizures, and developmental delay10.2
36blindness10.2
37epilepsy with generalized tonic-clonic seizures10.2
38influenza10.2
39hypothalamic hamartomas10.2
40hypotonia10.2
41myoclonus10.2
42neuroendocrine tumor10.2VIP
43benign neonatal seizures10.2
44dandy-walker malformation with intellectual disability, basal ganglia disease and seizures10.2
45cortical blindness10.2
46northern epilepsy10.2
47traumatic brain injury10.2
48hemimegalencephaly10.2
49myoclonic astatic epilepsy10.2
50ring chromosome 2010.2

Graphical network of the top 20 diseases related to Seizure Disorder:



Diseases related to seizure disorder

Symptoms for Seizure Disorder

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Drugs & Therapeutics for Seizure Disorder

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Drug clinical trials:

Search ClinicalTrials for Seizure Disorder

Search NIH Clinical Center for Seizure Disorder

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Seizure Disorder

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Anatomical Context for Seizure Disorder

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MalaCards organs/tissues related to Seizure Disorder:

32
Brain, Testes, Temporal lobe, Eye, Bone, Heart, Kidney

Animal Models for Seizure Disorder or affiliated genes

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MGI Mouse Phenotypes related to Seizure Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9SCN1A, SCN1B, SCN9A, SEZ6L2, VIP, GHRL
2MP:00036317.7KCNQ2, SCN1A, SCN1B, SCN9A, SEZ6L2, POLG
3MP:00053867.5CDKL5, KCNQ2, SCN1A, SCN1B, SCN9A, SEZ6L2
4MP:00107687.5KCNQ2, SCN1A, SCN1B, SCN9A, POLG, VIP

Publications for Seizure Disorder

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Articles related to Seizure Disorder:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Seizure disorder secondary to remote gunshot wound of the head: a case of sudden unexpected death in epilepsy. (24771478)
2014
2
Childhood insulinoma masquerading as seizure disorder. (24698060)
2014
3
Seizure disorder. (23923286)
2013
4
Assessing Systems of Care for US Children with Epilepsy/Seizure Disorder. (24228175)
2013
5
Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. (24370333)
2013
6
Clobazam approved for seizure disorder. (22095800)
2011
7
Successful treatment of a seizure disorder with chronic high-dose chloral hydrate: a pediatric case report. (21268525)
2010
8
Postictal transient hyperammonemia as an indicator of seizure disorder. (20606448)
2010
9
Regional blockade in patients with a history of a seizure disorder. (19535721)
2009
10
Nonseminomatous germ cell tumor with seizure disorder and mental retardation. (20531999)
2009
11
A novel microdeletion at 16p11.2 harbors candidate genes for aortic valve development, seizure disorder, and mild mental retardation. (17568417)
2007
12
Cutaneous manifestations of seizure disorder in children--a study of 100 seizure patients. (17958825)
2007
13
Post-traumatic seizure disorder following acquired brain injury. (17364531)
2007
14
Adult-onset seizure disorder in the 18q deletion syndrome. (16541216)
2006
15
Hyperphosphatasia with neurologic deficit: a pyridoxine-responsive seizure disorder? (16638507)
2006
16
It's time to eliminate the term seizure disorder from our lexicon. (15730547)
2005
17
Measuring depressive symptoms among treatment-resistant seizure disorder patients: POMS Depression scale as an alternative to the BDI-II. (16005686)
2005
18
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
19
A cost comparison of alternative regimens for treatment-refractory partial seizure disorder: an econometric analysis. (16330300)
2005
20
Effect of comorbidities on medical care use and cost among refractory patients with partial seizure disorder. (15939673)
2005
21
Identification and treatment of bronchoconstriction induced by a vagus nerve stimulator employed for management of seizure disorder. (15654007)
2005
22
Behaviour problems in children and adolescents with seizure disorder: associations and risk factors. (15797354)
2005
23
Computed tomography and childhood seizure disorder in Ibadan. (15287299)
2004
24
Congenital hypoparathyroidism, associated in this case with mental retardation, seizure disorder, and short stature. (11951813)
2002
25
Hmong child with myoclonic seizure disorder. (10961799)
2000
26
Intractable seizure disorder associated with chronic herpes infection. HSV1 detection in tissue by the polymerase chain reaction. (9548334)
1998
27
Blink rate in pediatric complex partial seizure disorder. (9844984)
1998
28
Hippocampal connexin 43 expression in human complex partial seizure disorder. (9184118)
1997
29
The phenomenology of psychosis associated with complex partial seizure disorder. (9167835)
1997
30
Effects of hemispheric side of injury, age at injury, and presence of seizure disorder on functional ear and hand asymmetries in hemiplegic children. (8852875)
1996
31
Pathology of chronic herpes infection associated with seizure disorder: a report of two cases with tissue detection of herpes simplex virus 1 by the polymerase chain reaction. (8736603)
1995
32
Primary generalized seizure disorder: correlation of epileptiform discharges with seizure frequency. (8422844)
1993
33
Improvement of central auditory function after partial temporal lobectomy in a patient with seizure disorder. (2132597)
1990
34
Bromide therapy for pediatric seizure disorder intractable to other antiepileptic drugs. (2299142)
1990
35
Acquired aphasia with seizure disorder in childhood. (2473957)
1989
36
Seizure disorder or panic disorder? (3341486)
1988
37
Recognition memory of item, associative and serial-order information after temporal lobectomy for seizure disorder. (3362345)
1988
38
Hospital management of a patient with von Willebrand's disease and a seizure disorder: case report. (3151902)
1988
39
Cardiac hypertrophy associated with ACTH therapy for childhood seizure disorder. (2821097)
1987
40
Phenytoin vs carbamazepine in seizure disorder. (3793691)
1986
41
Effect of phenothiazines on serum antiepileptic drug concentrations in psychiatric patients with seizure disorder. (4082239)
1985
42
Computed tomography in chronic seizure disorder caused by glioma. (3966881)
1985
43
Refractory seizure disorder due to hypocalcemia. (4055688)
1985
44
A narcissistic reaction in a six-year-old girl with a seizure disorder. (6660339)
1983
45
Maternal seizure disorder, outcome of pregnancy, and neurologic abnormalities in the children. (6890158)
1982
46
Seizure disorder and substance abuse. (7139454)
1982
47
Water intoxication secondary to feeding mismanagement. A preventable form of familial seizure disorder in infants. (7457441)
1981
48
Seizure disorders associated with neurosyphilis. (1253663)
1976
49
Congenital retardation and central motor defect with later evolution of seizure disorder, orofacial dysplasia, and amyotrophy. A clinicopathologic report. (986030)
1976
50
Seizure disorder in mothers of children with orofacial clefts: a case-control study. (4810733)
1974

Variations for Seizure Disorder

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Expression for genes affiliated with Seizure Disorder

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Expression patterns in normal tissues for genes affiliated with Seizure Disorder

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Pathways for genes affiliated with Seizure Disorder

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Compounds for genes affiliated with Seizure Disorder

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Compounds related to Seizure Disorder according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1acipimox44 2811.0HMGCR, GHRL
2bc-iii289.9SCN1A, SCN2A
3atx-ii289.9SCN1A, SCN2A
4aft-ii289.9SCN1A, SCN2A
5ranolazine50 44 1111.9HMGCR, SCN9A
6lamotrigine44 50 1111.8SCN2A, SCN1A
7topiramate44 50 24 1112.8SCN1A, SCN2A
8oxyntomodulin44 6110.7VIP, GHRL
9erythromycin44 2 50 1112.7VIP, GHRL, HMGCR
10valproic acid44 50 24 1112.7GHRL, POLG, SCN2A
11saxitoxin289.5SCN1A, SCN9A, SCN2A
12thyroxine44 2410.5HMGCR, GHRL, VIP
13batrachotoxin289.5SCN1A, SCN9A, SCN2A
14gaba449.4GHRL, VIP, PNPO
15histamine44 28 2411.4KCNQ2, VIP, GHRL, HMGCR
16niacin44 1110.3HMGCR, QPRT
17lactate449.3POLG, VIP, GHRL, HMGCR
18phrixotoxin 3619.3SCN2A, SCN1A, SCN1B, SCN9A
19qx 314 chloride619.3SCN1A, SCN1B, SCN9A, SCN2A
20tetrodotoxin citrate619.3SCN1A, SCN1B, SCN9A, SCN2A
21veratridine44 61 2811.3SCN1A, SCN1B, SCN9A, SCN2A
22zonisamide44 50 1111.2SCN2A, SCN9A, SCN1B, SCN1A
23epinephrine44 24 1111.1HMGCR, GHRL, VIP
24potassium44 24 1111.1KCNQ2, SCN1A, SCN1B, VIP, GHRL
25sodium44 249.9SCN2A, SCN9A, SCN1B, SCN1A, KCNQ2
26tetrodotoxin44 61 2810.8VIP, SCN2A, SCN9A, SCN1B, SCN1A

GO Terms for genes affiliated with Seizure Disorder

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Cellular components related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon initial segmentGO:0431949.5SCN1A, KCNQ2
2T-tubuleGO:0303159.4SCN1A, SCN1B, SCN2A
3neuronal cell bodyGO:0430259.4VIP, SEZ6L2, SCN1A
4intercalated discGO:0147049.3SCN1A, SCN1B, SCN2A
5node of RanvierGO:0332689.2KCNQ2, SCN1A, SCN1B, SCN2A
6voltage-gated sodium channel complexGO:0015189.0SCN2A, SCN9A, SCN1B, SCN1A

Biological processes related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal action potentialGO:0192289.5SCN9A, SCN1A
2neuronal action potential propagationGO:0192279.5SCN1B, SCN1A
3sodium ion transportGO:0068149.0SCN1A, SCN9A, SCN2A
4sodium ion transmembrane transportGO:0357258.9SCN2A, SCN9A, SCN1B, SCN1A

Molecular functions related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:0052488.9SCN2A, SCN9A, SCN1B, SCN1A

Products for genes affiliated with Seizure Disorder

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Sources for Seizure Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet