MCID: SZR006
MIFTS: 40

Seizure Disorder malady

Summaries for Seizure Disorder

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 The epilepsies are a spectrum of brain disorders ranging from severe, life-threatening and disabling, to ones that are much more benign. In epilepsy, the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior or sometimes convulsions, muscle spasms, and loss of consciousness. The epilepsies have many possible causes and there are several types of seizures. Anything that disturbs the normal pattern of neuron activity?from illness to brain damage to abnormal brain development?can lead to seizures. Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters, changes in important features of brain cells called channels, or some combination of these and other factors. Having a single seizure as the result of a high fever (called febrile seizure) or head injury does not necessarily mean that a person has epilepsy. Only when a person has had two or more seizures is he or she considered to have epilepsy. A measurement of electrical activity in the brain and brain scans such as magnetic resonance imaging or computed tomography are common diagnostic tests for epilepsy.

MalaCards: Seizure Disorder is related to scn1a-related seizure disorders and early myoclonic encephalopathy. An important gene associated with Seizure Disorder is SCN2A (sodium channel, voltage-gated, type II, alpha subunit), and among its related pathways are Sodium channels and transporters: inward current and Synaptic transmission: ion currents. The compounds aft-ii and bc-iii have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and small intestine, and related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:64 Epilepsy (from the Ancient Greek verb ἐπιλαμβάνειν meaning \"to seize, possess, or... more...

Aliases & Classifications for Seizure Disorder

Sources:
44NINDS
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Aliases & Descriptions:

seizure disorder 44


Related Diseases for Seizure Disorder

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Seizure Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1scn1a-related seizure disorders30.2SCN1A
2early myoclonic encephalopathy29.7SCN1B, SCN1A
3kifafa seizure disorder10.3
4mental retardation10.3
5panic disorder10.2
6insulinoma10.2
7n syndrome10.1
8aphasia10.1
9temporal lobe epilepsy10.0
10microcephaly10.0
11anxiety disorder10.0
12sturge-weber syndrome10.0
13weber syndrome10.0
14head injury10.0
15generalized epilepsy with febrile seizures plus10.0SCN1B
16epilepsy syndrome10.0SCN2A
17rett syndrome10.0CDKL5
18dravet syndrome10.0SCN1A, SCN1B
19neuropathy10.0POLG, SCN9A
20multiple sclerosis10.0HMGCR
21idiopathic generalized epilepsy10.0SCN1A, KCNQ2
22cholera10.0VIP
23benign familial neonatal-infantile seizures10.0KCNQ2, SCN1B, SCN1A
24frontal lobe epilepsy10.0SCN1A, SCN1B, KCNQ2
25febrile seizures10.0KCNQ2, SCN1B, SCN1A
26glucagonoma10.0GHRL, VIP
27brain disease10.0SCN1A, POLG, CDKL5, PNPO
28lipodystrophy10.0HMGCR, POLG
29prion disease10.0KCNQ2, SCN1A, POLG, CDKL5
30moyamoya disease9.8
31atypical autism9.8
32merrf syndrome9.8
33expressive language disorder9.8
34cysticercosis9.8
35arteriovenous malformation9.8
36hyperprolactinemia9.8
37hypoparathyroidism9.8
38wegener's granulomatosis9.8
39fukuyama congenital muscular dystrophy9.8
40west syndrome9.8
41obsessive-compulsive disorder9.8
42multiple personality disorder9.8
43panhypopituitarism9.8
44osteomalacia9.8
45agoraphobia9.8
46japanese encephalitis9.8
47pain disorder9.8
48cleft palate9.8
49hypoglycemia9.8
50prader-willi syndrome9.8

Graphical network of the top 20 diseases related to Seizure Disorder:



Diseases related to seizure disorder

Clinical Features for Seizure Disorder

Drugs & Therapeutics for Seizure Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Seizure Disorder

Drug clinical trials:

Search ClinicalTrials for Seizure Disorder

Search NIH Clinical Center for Seizure Disorder

Search CenterWatch for Seizure Disorder

Genetic Tests for Seizure Disorder

Anatomical Context for Seizure Disorder

Sources:
33MalaCards
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MalaCards organs/tissues related to Seizure Disorder:

33
Brain, Heart, Small intestine, Kidney, Fetal brain, Temporal lobe

Animal Models for Seizure Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Seizure Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7KCNQ2, SCN1B, SCN9A, SCN1A, POLG, CDKL5
2MP:00053867.5CELF4, VIP, KCNQ2, SCN1B, SCN9A, SCN1A
3MP:00107687.4KCNQ2, SCN1B, SCN9A, SCN1A, POLG, HMGCR

Publications for Seizure Disorder

Sources:
51PubMed
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Articles related to Seizure Disorder:

(show top 50)    (show all 238)
idTitleAuthorsYear
1
Teachers' knowledge and attitudes towards seizure disorder: a comparative study of urban and rural school teachers in Akwa Ibom State, Nigeria. (23771463)
2013
2
A 44-year-old patient with a new-onset seizure disorder after vaccination against Japanese encephalitis: a case report. (23497732)
2013
3
Comparisons of childhood trauma, alexithymia, and defensive styles in patients with psychogenic non-epileptic seizures vs. epilepsy: Implications for the etiology of conversion disorder. (23915770)
2013
4
The impact of methylphenidate on seizure frequency and severity in children with attention-deficit-hyperactivity disorder and difficult-to-treat epilepsies. (23480530)
2013
5
Epileptic seizures, movement disorders, and breathing disturbances in Rett syndrome: diagnostic relevance of video-polygraphy. (23103540)
2012
6
Risk and causes of death in children with a seizure disorder. (22571767)
2012
7
Etiology of a genetically complex seizure disorder in Celf4 mutant mice. (21745337)
2011
8
Variable expressivity of a novel mutation in the SCN1A gene leading to an autosomal dominant seizure disorder. (21775168)
2011
9
Dextromethorphan abuse masquerading as a recurrent seizure disorder. (21378523)
2011
10
First-onset psychotic disorder concurrent with a first-onset seizure disorder. (22231334)
2011
11
A novel p.Arg970X mutation in the last exon of the CDKL5 gene resulting in late-onset seizure disorder. (19428276)
2010
12
Regional blockade in patients with a history of a seizure disorder. (19535721)
2009
13
Nonseminomatous germ cell tumor with seizure disorder and mental retardation. (20531999)
2009
14
Combination of infantile spasms, non-epileptic seizures and complex movement disorder: a new case of ARX-related epilepsy. (18468866)
2008
15
Complex seizure disorder caused by Brunol4 deficiency in mice. (17677002)
2007
16
Hyperphosphatasia with neurologic deficit: a pyridoxine-responsive seizure disorder? (16638507)
2006
17
Why conversion seizures should be classified as a dissociative disorder. (16530593)
2006
18
Ginkgo biloba use in nursing home elderly with epilepsy or seizure disorder. (16499756)
2006
19
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
20
Effect of comorbidities on medical care use and cost among refractory patients with partial seizure disorder. (15939673)
2005
21
Mental retardation, keratoconus, febrile seizures and sinoatrial block: a previously undescribed autosomal recessive disorder. (15811017)
2005
22
Epilepsy and seizure disorder. (16060952)
2005
23
Seizure disorder as a risk factor for gastroesophageal reflux in children with neurodevelopmental disabilities. (15248009)
2004
24
Congenital hypoparathyroidism, associated in this case with mental retardation, seizure disorder, and short stature. (11951813)
2002
25
Predisposed susceptibility and partial seizure disorder. (11902316)
2001
26
Hmong child with myoclonic seizure disorder. (10961799)
2000
27
Isolated dural tuberculosis presenting as seizure disorder in a dialysis patient. (9481740)
1998
28
Temporal profile of connexin 43 mRNA expression in a tetanus toxin-induced seizure disorder. (10343969)
1998
29
Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. (9126059)
1997
30
Case study: seizure disorder presenting as panic disorder with agoraphobia. (9291732)
1997
31
Cohort study of incidence of sudden unexplained death in persons with seizure disorder treated with antiepileptic drugs in Saskatchewan, Canada. (8001505)
1995
32
Cysticercosis as a cause of seizure disorder in pregnancy: case report and review of literature. (7857431)
1994
33
Insulinoma in pregnancy presenting as a seizure disorder: a case report. (1505386)
1992
34
Formal thought disorder in pediatric complex partial seizure disorder. (1429965)
1992
35
Epilepsia partialis continua and other seizures arising from the precentral gyrus: high incidence in patients with Rasmussen syndrome and neuronal migration disorders. (1456391)
1992
36
Seizure disorder or panic disorder? (3341486)
1988
37
Hospital management of a patient with von Willebrand's disease and a seizure disorder: case report. (3151902)
1988
38
Cardiac tachyarrhythmias in hereditary long QT syndromes presenting as a seizure disorder. (3742343)
1986
39
Effect of phenothiazines on serum antiepileptic drug concentrations in psychiatric patients with seizure disorder. (4082239)
1985
40
Refractory seizure disorder due to hypocalcemia. (4055688)
1985
41
A narcissistic reaction in a six-year-old girl with a seizure disorder. (6660339)
1983
42
Isolated congenital hypoplastic bicuspid pulmonary valve. Report of a case associated with seizure disorder in a 27-year-old man. (6837541)
1983
43
Focal seizure disorder complicating iodophendylate myelography. (6101766)
1980
44
Hematuria in seizure disorder patient. (458954)
1979
45
Sturge-Weber Syndrome: presentation as a focal seizure disorder without nevus flammeus. (97040)
1978
46
Dialysis encephalopathy: a possible seizure disorder. (1033480)
1976
47
Seizure disorder in mothers of children with orofacial clefts: a case-control study. (4810733)
1974
48
Remediable seizure disorder due to alimentary hypoglycemia. (5534990)
1970
49
Ictal behavior disturbance as the only manifestation of seizure disorder: case report. (14450872)
1962
50
Incidence of audiogenic seizures following experimental induction of middle ear disorder. (14946268)
1952

Genetic Variations for Seizure Disorder

Expression for genes affiliated with Seizure Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seizure Disorder

Search GEO for disease gene expression data for Seizure Disorder.

Pathways for genes affiliated with Seizure Disorder

Sources:
12EMD Millipore, 54Reactome
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Pathways related to Seizure Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SCN1A, SCN9A, SCN2A
29.4KCNQ2, SCN2A, SCN9A, SCN1A
3
Hide members
9.2KCNQ2, SCN2A, SCN1B, SCN9A, SCN1A
49.2SCN1A, SCN9A, SCN1B, SCN2A, KCNQ2

Compounds for genes affiliated with Seizure Disorder

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Seizure Disorder according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1aft-ii2910.3SCN2A, SCN1A
2bc-iii2910.3SCN2A, SCN1A
3atx-ii2910.2SCN2A, SCN1A
4lamotrigine45 1111.1SCN2A, SCN1A
5saxitoxin2910.1SCN1A, SCN9A, SCN2A
6batrachotoxin2910.1SCN1A, SCN9A, SCN2A
7ranolazine45 1111.0SCN9A, HMGCR
8phrixotoxin 3609.9SCN1A, SCN2A, SCN1B, SCN9A
9qx 314 chloride609.9SCN2A, SCN1B, SCN9A, SCN1A
10tetrodotoxin citrate609.9SCN2A, SCN1B, SCN9A, SCN1A
11veratridine45 60 2911.9SCN2A, SCN1B, SCN9A, SCN1A
12zonisamide45 1110.9SCN2A, SCN1B, SCN9A, SCN1A
13oxyntomodulin45 6010.7VIP, GHRL
14acipimox45 2910.6HMGCR, GHRL
15tetrodotoxin45 60 2911.5VIP, SCN2A, SCN1B, SCN9A, SCN1A
16erythromycin45 50 2 1112.4VIP, GHRL, HMGCR
17sodium45 2410.4KCNQ2, SCN2A, SCN1B, SCN9A, SCN1A
18potassium45 11 2411.2VIP, KCNQ2, SCN1B, SCN1A, GHRL
19histamine45 29 2411.0HMGCR, GHRL, KCNQ2, VIP
20thyroxine45 2410.0HMGCR, GHRL, VIP
21lactate459.0HMGCR, POLG, GHRL, VIP

GO Terms for genes affiliated with Seizure Disorder

Sources:
16Gene Ontology
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Cellular components related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon initial segmentGO:0431949.8SCN1A, KCNQ2
2T-tubuleGO:0303159.7SCN2A, SCN1B, SCN1A
3voltage-gated sodium channel complexGO:0015189.6SCN1A, SCN9A, SCN1B, SCN2A
4intercalated discGO:0147049.5SCN1A, SCN1B, SCN2A
5node of RanvierGO:0332689.4SCN1A, SCN1B, SCN2A, KCNQ2

Biological processes related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of action potential in neuronGO:01922810.0SCN1A, SCN9A
2neuronal action potential propagationGO:0192279.7SCN1A, SCN1B
3sodium ion transportGO:0068149.7SCN1A, SCN9A, SCN2A

Molecular functions related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:0052489.6SCN1A, SCN9A, SCN1B, SCN2A

Products for genes affiliated with Seizure Disorder

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  • Lysates
  • Antibodies

Sources for Seizure Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet