MCID: SZR006
MIFTS: 43

Seizure Disorder malady

Genetic diseases (common) category

Summaries for Seizure Disorder

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45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 The epilepsies are a spectrum of brain disorders ranging from severe, life-threatening and disabling, to ones that are much more benign. In epilepsy, the normal pattern of neuronal activity becomes disturbed, causing strange sensations, emotions, and behavior or sometimes convulsions, muscle spasms, and loss of consciousness. The epilepsies have many possible causes and there are several types of seizures. Anything that disturbs the normal pattern of neuron activity?from illness to brain damage to abnormal brain development?can lead to seizures. Epilepsy may develop because of an abnormality in brain wiring, an imbalance of nerve signaling chemicals called neurotransmitters, changes in important features of brain cells called channels, or some combination of these and other factors. Having a single seizure as the result of a high fever (called febrile seizure) or head injury does not necessarily mean that a person has epilepsy. Only when a person has had two or more seizures is he or she considered to have epilepsy. A measurement of electrical activity in the brain and brain scans such as magnetic resonance imaging or computed tomography are common diagnostic tests for epilepsy.

MalaCards: Seizure Disorder is related to mental retardation and scn1a-related seizure disorders. An important gene associated with Seizure Disorder is SEZ6L2 (seizure related 6 homolog (mouse)-like 2), and among its related pathways are G-Beta Gamma Signaling and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The compounds acipimox and aft-ii have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related mouse phenotypes are normal and nervous system.

Wikipedia:66 Epilepsy (from the Ancient Greek verb ???????????? meaning \"to seize, possess, or afflict\") is a group... more...

Aliases & Classifications for Seizure Disorder

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45NINDS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

seizure disorder 45


Related Diseases for Seizure Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Seizure Disorder family:

Scn1a-Related Seizure Disorders

Diseases related to Seizure Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1mental retardation30.4CDKL5, VIP, KCNQ2
2scn1a-related seizure disorders30.3SCN1A
3early myoclonic encephalopathy29.8SCN1B, SCN1A
4kifafa seizure disorder10.3
5insulinoma10.2
6panic disorder10.1
7aphasia10.1
8epilepsy syndrome10.1SCN2A
9neuroendocrine tumor10.1VIP
10dravet syndrome10.0SCN1A, SCN1B
11lipodystrophy10.0HMGCR, POLG
12glucagonoma10.0GHRL, VIP
13idiopathic generalized epilepsy10.0KCNQ2, SCN1A
14microcephaly10.0
15temporal lobe epilepsy10.0
16long qt syndrome10.0
17sturge-weber syndrome10.0
18weber syndrome10.0
19aneurysm10.0
20head injury10.0
21convulsions benign familial neonatal dominant form10.0KCNQ2, SCN1A, SCN1B
22frontal lobe epilepsy10.0SCN1B, SCN1A, KCNQ2
23febrile seizures10.0KCNQ2, SCN1B, SCN1A
24brain disease10.0SCN1A, POLG, CDKL5, PNPO
25cerebrovascular disease10.0VIP, GHRL, HMGCR
26prion disease10.0KCNQ2, POLG, CDKL5, SCN1A
27congenital heart disease9.9HMGCR, GHRL, VIP
28merrf syndrome9.9
29obsessive-compulsive disorder9.9
30panhypopituitarism9.9
31neuronitis9.9
32cleft lip9.9
33japanese encephalitis9.9
34agoraphobia9.9
35osteomalacia9.9
36hypoglycemia9.9
37tetralogy of fallot9.9
38prader-willi syndrome9.9
39infertility9.9
40von willebrand's disease9.9
41cysticercosis9.9
42arteriovenous malformation9.9
43hyperprolactinemia9.9
44cerebritis9.9
45hypoparathyroidism9.9
46fetal alcohol syndrome9.9
47wegener's granulomatosis9.9
48moyamoya disease9.9
49autism spectrum disorder9.9
50cataract9.9

Graphical network of the top 20 diseases related to Seizure Disorder:



Diseases related to seizure disorder

Symptoms for Seizure Disorder

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Drugs & Therapeutics for Seizure Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Seizure Disorder

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Genetic Tests for Seizure Disorder

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Anatomical Context for Seizure Disorder

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34MalaCards
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MalaCards organs/tissues related to Seizure Disorder:

34
Brain, Testes, Temporal lobe, Eye, Bone, Heart, Kidney

Animal Models for Seizure Disorder or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Seizure Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.9HMGCR, VIP, SCN1A, SCN1B, SCN9A, SEZ6L2
2MP:00036317.7CDKL5, POLG, SEZ6L2, SCN9A, SCN1B, SCN1A
3MP:00053867.5CDKL5, SCN9A, SEZ6L2, VIP, CELF4, GHRL
4MP:00107687.5CELF4, VIP, POLG, SCN9A, SCN1B, SCN1A

Publications for Seizure Disorder

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53PubMed
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Articles related to Seizure Disorder:

(show top 50)    (show all 188)
idTitleAuthorsYear
1
Seizure disorder. (23923286)
2013
2
Assessing Systems of Care for US Children with Epilepsy/Seizure Disorder. (24228175)
2013
3
Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. (24370333)
2013
4
Clobazam approved for seizure disorder. (22095800)
2011
5
Successful treatment of a seizure disorder with chronic high-dose chloral hydrate: a pediatric case report. (21268525)
2010
6
Postictal transient hyperammonemia as an indicator of seizure disorder. (20606448)
2010
7
Regional blockade in patients with a history of a seizure disorder. (19535721)
2009
8
Nonseminomatous germ cell tumor with seizure disorder and mental retardation. (20531999)
2009
9
A novel microdeletion at 16p11.2 harbors candidate genes for aortic valve development, seizure disorder, and mild mental retardation. (17568417)
2007
10
Cutaneous manifestations of seizure disorder in children--a study of 100 seizure patients. (17958825)
2007
11
Post-traumatic seizure disorder following acquired brain injury. (17364531)
2007
12
Adult-onset seizure disorder in the 18q deletion syndrome. (16541216)
2006
13
Hyperphosphatasia with neurologic deficit: a pyridoxine-responsive seizure disorder? (16638507)
2006
14
It's time to eliminate the term seizure disorder from our lexicon. (15730547)
2005
15
Measuring depressive symptoms among treatment-resistant seizure disorder patients: POMS Depression scale as an alternative to the BDI-II. (16005686)
2005
16
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. (16264405)
2005
17
A cost comparison of alternative regimens for treatment-refractory partial seizure disorder: an econometric analysis. (16330300)
2005
18
Effect of comorbidities on medical care use and cost among refractory patients with partial seizure disorder. (15939673)
2005
19
Identification and treatment of bronchoconstriction induced by a vagus nerve stimulator employed for management of seizure disorder. (15654007)
2005
20
Behaviour problems in children and adolescents with seizure disorder: associations and risk factors. (15797354)
2005
21
Computed tomography and childhood seizure disorder in Ibadan. (15287299)
2004
22
Congenital hypoparathyroidism, associated in this case with mental retardation, seizure disorder, and short stature. (11951813)
2002
23
Hmong child with myoclonic seizure disorder. (10961799)
2000
24
Intractable seizure disorder associated with chronic herpes infection. HSV1 detection in tissue by the polymerase chain reaction. (9548334)
1998
25
Blink rate in pediatric complex partial seizure disorder. (9844984)
1998
26
Hippocampal connexin 43 expression in human complex partial seizure disorder. (9184118)
1997
27
The phenomenology of psychosis associated with complex partial seizure disorder. (9167835)
1997
28
Effects of hemispheric side of injury, age at injury, and presence of seizure disorder on functional ear and hand asymmetries in hemiplegic children. (8852875)
1996
29
Pathology of chronic herpes infection associated with seizure disorder: a report of two cases with tissue detection of herpes simplex virus 1 by the polymerase chain reaction. (8736603)
1995
30
Primary generalized seizure disorder: correlation of epileptiform discharges with seizure frequency. (8422844)
1993
31
Chronic atypical seizure disorder and cataracts due to delayed diagnosis of pseudohypoparathyroidism. (1413750)
1992
32
Improvement of central auditory function after partial temporal lobectomy in a patient with seizure disorder. (2132597)
1990
33
Bromide therapy for pediatric seizure disorder intractable to other antiepileptic drugs. (2299142)
1990
34
Acquired aphasia with seizure disorder in childhood. (2473957)
1989
35
Seizure disorder or panic disorder? (3341486)
1988
36
Recognition memory of item, associative and serial-order information after temporal lobectomy for seizure disorder. (3362345)
1988
37
Hospital management of a patient with von Willebrand's disease and a seizure disorder: case report. (3151902)
1988
38
Cardiac hypertrophy associated with ACTH therapy for childhood seizure disorder. (2821097)
1987
39
Phenytoin vs carbamazepine in seizure disorder. (3793691)
1986
40
Effect of phenothiazines on serum antiepileptic drug concentrations in psychiatric patients with seizure disorder. (4082239)
1985
41
Computed tomography in chronic seizure disorder caused by glioma. (3966881)
1985
42
Refractory seizure disorder due to hypocalcemia. (4055688)
1985
43
A narcissistic reaction in a six-year-old girl with a seizure disorder. (6660339)
1983
44
Maternal seizure disorder, outcome of pregnancy, and neurologic abnormalities in the children. (6890158)
1982
45
Seizure disorder and substance abuse. (7139454)
1982
46
Water intoxication secondary to feeding mismanagement. A preventable form of familial seizure disorder in infants. (7457441)
1981
47
Moyamoya disease presenting as a seizure disorder. A case report. (889487)
1977
48
Seizure disorders associated with neurosyphilis. (1253663)
1976
49
Congenital retardation and central motor defect with later evolution of seizure disorder, orofacial dysplasia, and amyotrophy. A clinicopathologic report. (986030)
1976
50
Seizure disorder in mothers of children with orofacial clefts: a case-control study. (4810733)
1974

Variations for Seizure Disorder

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Expression for genes affiliated with Seizure Disorder

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seizure Disorder

Search GEO for disease gene expression data for Seizure Disorder.

Pathways for genes affiliated with Seizure Disorder

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51PathCards, 54QIAGEN, 13EMD Millipore, 56Reactome
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Compounds for genes affiliated with Seizure Disorder

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46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Seizure Disorder according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1acipimox46 3011.0HMGCR, GHRL
2aft-ii309.9SCN2A, SCN1A
3atx-ii309.9SCN2A, SCN1A
4bc-iii309.9SCN2A, SCN1A
5ranolazine52 46 1211.9SCN9A, HMGCR
6lamotrigine46 52 1211.8SCN1A, SCN2A
7topiramate46 52 25 1212.8SCN1A, SCN2A
8oxyntomodulin46 6210.7GHRL, VIP
9erythromycin46 3 52 1212.7VIP, HMGCR, GHRL
10valproic acid46 52 25 1212.7POLG, SCN2A, GHRL
11saxitoxin309.5SCN2A, SCN9A, SCN1A
12thyroxine46 2510.5HMGCR, GHRL, VIP
13batrachotoxin309.5SCN2A, SCN1A, SCN9A
14gaba469.4PNPO, VIP, GHRL
15histamine46 30 2511.4GHRL, HMGCR, VIP, KCNQ2
16niacin46 1210.3HMGCR, QPRT
17lactate469.3HMGCR, GHRL, POLG, VIP
18phrixotoxin 3629.3SCN1B, SCN1A, SCN9A, SCN2A
19tetrodotoxin citrate629.3SCN9A, SCN1B, SCN1A, SCN2A
20qx 314 chloride629.3SCN2A, SCN9A, SCN1B, SCN1A
21veratridine46 62 3011.3SCN9A, SCN1B, SCN2A, SCN1A
22zonisamide46 52 1211.2SCN2A, SCN9A, SCN1B, SCN1A
23epinephrine46 25 1211.1VIP, GHRL, HMGCR
24potassium46 25 1211.1VIP, SCN1B, KCNQ2, GHRL, SCN1A
25sodium46 259.9SCN1B, SCN1A, SCN9A, KCNQ2, SCN2A
26tetrodotoxin46 62 3010.8SCN1A, SCN1B, SCN9A, SCN2A, VIP

GO Terms for genes affiliated with Seizure Disorder

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17Gene Ontology
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Cellular components related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon initial segmentGO:0431949.5SCN1A, KCNQ2
2T-tubuleGO:0303159.4SCN1A, SCN1B, SCN2A
3neuronal cell bodyGO:0430259.4VIP, SEZ6L2, SCN1A
4intercalated discGO:0147049.3SCN1A, SCN1B, SCN2A
5node of RanvierGO:0332689.2KCNQ2, SCN1A, SCN1B, SCN2A
6voltage-gated sodium channel complexGO:0015189.0SCN2A, SCN9A, SCN1B, SCN1A

Biological processes related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal action potentialGO:0192289.5SCN9A, SCN1A
2neuronal action potential propagationGO:0192279.5SCN1B, SCN1A
3sodium ion transportGO:0068149.0SCN1A, SCN9A, SCN2A
4sodium ion transmembrane transportGO:0357258.9SCN2A, SCN9A, SCN1B, SCN1A

Molecular functions related to Seizure Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:0052488.9SCN2A, SCN9A, SCN1B, SCN1A

Products for genes affiliated with Seizure Disorder

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  • Antibodies
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Sources for Seizure Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet