MCID: SMN008
MIFTS: 44

Semantic Dementia malady

Categories: Rare diseases, Neuronal diseases, Mental diseases

Aliases & Classifications for Semantic Dementia

Aliases & Descriptions for Semantic Dementia:

Name: Semantic Dementia 50 51 56 52 69
Semantic Primary Progressive Aphasia 50 56
Semantic Variant Ppa 50 56
Dementia - Semantic 51

Characteristics:

Orphanet epidemiological data:

56
semantic dementia
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA100069
ICD10 via Orphanet 34 G31.0
UMLS via Orphanet 70 C0338462

Summaries for Semantic Dementia

NINDS : 51 Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick’s disease, the name and classification of FTD has been a topic of discussion for over a century.  The current designation of the syndrome groups together Pick’s disease, primary progressive aphasia, and semantic dementia as FTD.  Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex.  These designations will continue to be debated.  As it is defined today, the symptoms of FTD fall into two clinical patterns that involve either (1) changes in behavior, or (2) problems with language.  The first type features behavior that can be either impulsive (disinhibited) or bored and listless (apathetic) and includes inappropriate social behavior; lack of social tact; lack of empathy; distractability; loss of insight into the behaviors of oneself and others; an increased interest in sex; changes in food preferences; agitation or, conversely, blunted emotions; neglect of personal hygiene; repetitive or compulsive behavior, and decreased energy and motivation.  The second type primarily features symptoms of language disturbance, including difficulty making or understanding speech, often in conjunction with the behavioral type’s symptoms.  Spatial skills and memory remain intact.  There is a strong genetic component to the disease; FTD often runs in families.

MalaCards based summary : Semantic Dementia, also known as semantic primary progressive aphasia, is related to dementia, frontotemporal and pick disease. An important gene associated with Semantic Dementia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Neuroscience and Ovarian tumor domain proteases. The drugs Dopamine and Memantine have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and testes, and related phenotypes are behavior/neurological and cellular

Wikipedia : 71 Semantic dementia (SD) is a progressive neurodegenerative disorder characterized by loss of semantic... more...

Related Diseases for Semantic Dementia

Diseases related to Semantic Dementia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
id Related Disease Score Top Affiliating Genes
1 dementia, frontotemporal 11.6
2 pick disease 11.1
3 frontotemporal lobar degeneration with ubiquitin-positive inclusions 11.1
4 dementia 11.0
5 aphasia 10.4
6 keratosis palmoplantaris striata 10.3 APOE MAPT
7 protein r deficiency 10.2 GRN MAPT
8 femoral neuropathy 10.2 GRN MAPT
9 dyslexia 10.2
10 riedel's fibrosing thyroiditis 10.2 MAPT TARDBP
11 osteogenesis imperfecta, type vi 10.2 C9orf72 TARDBP
12 deafness, autosomal recessive 101 10.2 MAPT RPS27A
13 pulmonary systemic sclerosis 10.2 APOE MAPT
14 mcleod neuroacanthocytosis syndrome 10.1 MAPT PSEN1
15 spinal cord glioma 10.1 C9orf72 TARDBP
16 cerebral arteritis 10.1 PSEN1 TARDBP
17 fanconi renotubular syndrome 1 10.1 MAPT TARDBP
18 pancreatitis 10.1 GRN PSEN1
19 intracranial structure hemangioma 10.1 MAPT PSEN1
20 acquired metabolic disease 10.1 GRN PSEN1
21 cyprus facial neuromusculoskeletal syndrome 10.1 MAPT RPS27A
22 craniofacial and skeletal defects 10.1 MAPT RPS27A TARDBP
23 hyperglycemia 10.1 GRN PSEN1
24 carpenter syndrome 10.0 C9orf72 TREM2
25 pericardial tuberculosis 10.0 TARDBP VCP
26 adrenal cortical adenoma 10.0 TARDBP VCP
27 neuronitis 10.0
28 gata1-related thrombocytopenia 10.0 GRN MAPT PSEN1
29 hereditary paraganglioma-pheochromocytoma syndromes 10.0 GRN MAPT PSEN1
30 urethritis 10.0 APOE PSEN1 TARDBP
31 meckel syndrome 10 10.0 APOE MAPT PSEN1
32 gallbladder adenoma 10.0 CHMP2B MAPT RPS27A
33 social emotional agnosia 10.0 GRN PSEN1 TARDBP
34 cogan-reese syndrome 10.0 TARDBP VCP
35 color agnosia 10.0 GRN PSEN1 TARDBP
36 autoimmune disease of blood 10.0 GRN PSEN1 TARDBP
37 contagious pustular dermatitis 10.0 APOE MAPT PSEN1
38 encephalitozoonosis 10.0 APOE GRN PSEN1
39 pediatric mesenchymal chondrosarcoma 10.0 GRN PSEN1 TARDBP
40 chorioamnionitis 10.0 C9orf72 TARDBP
41 bone dysplasia azouz type 10.0 APOE MAPT
42 limited scleroderma 10.0 APOE PSEN1
43 alexia 10.0
44 cerebritis 10.0
45 prosopagnosia 10.0
46 alzheimer disease 10.0
47 corticobasal degeneration 10.0
48 mitochondrial dna depletion syndrome 3 9.9 C9orf72 GRN MAPT TARDBP
49 meier-gorlin syndrome 5 9.9 APOE GRN MAPT RPS27A
50 autotopagnosia 9.9 APOE C9orf72 GRN MAPT

Graphical network of the top 20 diseases related to Semantic Dementia:



Diseases related to Semantic Dementia

Symptoms & Phenotypes for Semantic Dementia

MGI Mouse Phenotypes related to Semantic Dementia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 PSEN1 APOE TARDBP C9orf72 VCP GRN
2 cellular MP:0005384 9.91 PSEN1 APOE TARDBP C9orf72 VCP GRN
3 hematopoietic system MP:0005397 9.87 PSEN1 APOE TARDBP C9orf72 VCP GRN
4 immune system MP:0005387 9.86 PSEN1 APOE TARDBP C9orf72 TREM2 VCP
5 nervous system MP:0003631 9.56 PSEN1 APOE TARDBP C9orf72 CHMP2B VCP
6 muscle MP:0005369 9.55 PSEN1 APOE TARDBP VCP MAPT
7 no phenotypic analysis MP:0003012 9.1 APOE TARDBP C9orf72 TREM2 GRN MAPT

Drugs & Therapeutics for Semantic Dementia

Drugs for Semantic Dementia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
3
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
4
Amantadine Approved Phase 4 768-94-5 2130
5 Fluorodeoxyglucose F18 Phase 4,Phase 2,Phase 1
6
Corticosterone Phase 4,Phase 1,Early Phase 1 50-22-6 5753
7
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
8 Serotonin Agents Phase 4,Phase 3,Phase 2
9 Serotonin Uptake Inhibitors Phase 4,Phase 2
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
11 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
12 Peripheral Nervous System Agents Phase 4,Phase 2
13 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
15 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
16 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
17 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
18 Antidepressive Agents Phase 4,Phase 2
19 Antidepressive Agents, Second-Generation Phase 4,Phase 2
20 Psychotropic Drugs Phase 4,Phase 3,Phase 2
21 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Antiparkinson Agents Phase 4,Phase 3,Phase 2
23
Iodine Phase 4 7553-56-2 807
24 cadexomer iodine Phase 4
25 Anti-Inflammatory Agents Phase 4
26 Analgesics Phase 4
27 Analgesics, Non-Narcotic Phase 4
28 Calamus Nutraceutical Phase 4
29
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
30
Busulfan Approved, Investigational Phase 2, Phase 3 55-98-1 2478
31
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
32
Miglustat Approved Phase 3,Phase 2,Phase 1 72599-27-0 51634
33
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
34
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
35
Exenatide Approved, Investigational Phase 3 141758-74-9 15991534
36 tannic acid Approved, Nutraceutical Phase 3
37
1-Deoxynojirimycin Experimental Phase 3,Phase 2 19130-96-2 1374
38 Prednisolone acetate Phase 2, Phase 3
39 Alkylating Agents Phase 2, Phase 3
40 Serotonin 5-HT2 Receptor Antagonists Phase 3
41 Serotonin Antagonists Phase 3
42 Glycoside Hydrolase Inhibitors Phase 3,Phase 2,Phase 1
43 Tranquilizing Agents Phase 3,Phase 2
44 Paliperidone Palmitate Phase 3
45 Dopamine Antagonists Phase 3
46 Dopamine D2 Receptor Antagonists Phase 3
47 Hypoglycemic Agents Phase 3,Phase 2,Phase 1
48 Anti-HIV Agents Phase 3,Phase 2,Phase 1
49 Prednisolone hemisuccinate Phase 2, Phase 3
50 Prednisolone phosphate Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 150)
id Name Status NCT ID Phase
1 Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia Completed NCT00545974 Phase 4
2 Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia Completed NCT00376051 Phase 4
3 Imaging of Brain Amyloid Plaques in the Aging Population Enrolling by invitation NCT00950430 Phase 4
4 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4
5 Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD) Terminated NCT00127114 Phase 4
6 Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD) Completed NCT01626378 Phase 3
7 Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia Completed NCT00594737 Phase 3
8 Application of Miglustat in Patients With Niemann-Pick Type C Completed NCT01760564 Phase 3
9 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3
10 Open-label Study of Flexible-dose Paliperidone ER (Extended Release) to Treat Adolescent Schizophrenia. Completed NCT00488319 Phase 3
11 Study of VTS-270 (2-hydroxypropyl-β-cyclodextrin) to Treat Niemann-Pick Type C1 (NPC1) Disease Recruiting NCT02534844 Phase 2, Phase 3
12 Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency Recruiting NCT02004691 Phase 2, Phase 3
13 Long-acting Exenatide and Cognitive Decline in Dysglycemic Patients Recruiting NCT02847403 Phase 3
14 Arimoclomol Prospective Study in Patients Diagnosed With NiemannPick Disease Type C Active, not recruiting NCT02612129 Phase 2, Phase 3
15 SurVival of Lysosomal Acid Lipase Deficiency (LAL-D) Infants Treated With SebelipAse aLfa Active, not recruiting NCT01371825 Phase 2, Phase 3
16 Open-Label Study of TRx0237 in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD) Enrolling by invitation NCT02245568 Phase 3
17 ALD-101 Adjuvant Therapy of Unrelated Umbilical Cord Blood Transfusion (UCBT) in Patients With Inherited Metabolic Diseases Terminated NCT00654433 Phase 3
18 Children With Lysosomal Acid Lipase Deficiency Who Previously Received Treatment With SBC-102 Terminated NCT01473875 Phase 2, Phase 3
19 Study to Assess the Safety, Tolerability, and Pharmacodynamic (PD) Effects of FRM-0334 in Subjects With Prodromal to Moderate Frontotemporal Dementia With Granulin Mutation Unknown status NCT02149160 Phase 2
20 Phase 1/2 Study of Vorinostat Therapy in Niemann-Pick Disease, Type C1 Completed NCT02124083 Phase 1, Phase 2
21 A Pilot Study to Explore the Safety and Tolerability of Galantamine HBr in the Treatment of Pick Complex/Frontotemporal Dementia Completed NCT00416169 Phase 2
22 Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine Completed NCT00975689 Phase 1, Phase 2
23 Efficacy and Tolerability of Memantine in Frontotemporal Dementia (FTD) Patients Completed NCT00200538 Phase 2
24 Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls. Completed NCT01890343 Phase 2
25 Electroencephalography (EEG) Biofeedback Training to Improve Executive Functioning and Memory in Adults With a Dementing Illness Completed NCT01168466 Phase 2
26 Double Blind Trial of DC Polarization in FTD Completed NCT00117858 Phase 2
27 Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Completed NCT00730314 Phase 1, Phase 2
28 Miglustat in Niemann-Pick Type C Disease Completed NCT00517153 Phase 2
29 CJD (Creutzfeldt-Jakob Disease) Quinacrine Study Completed NCT00183092 Phase 2
30 Citalopram to Enhance Cognition in HD Completed NCT00271596 Phase 2
31 Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia Recruiting NCT02862210 Phase 2
32 Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia Recruiting NCT01937013 Phase 2
33 Study of Pharmacokinetics and Preliminary Efficacy in Patients With Niemann-Pick C1 Recruiting NCT02912793 Phase 1, Phase 2
34 F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis Recruiting NCT02414230 Phase 2
35 Safety, Tolerability, PK, and Efficacy Evaluation of Repeat Ascending Doses of Olipudase Alfa in Pediatric Patients <18 Years of Age With Acid Sphingomyelinase Deficiency Recruiting NCT02292654 Phase 1, Phase 2
36 The Efficacy and Safety Study of High Dose Donepezil in Parkinson's Disease With Dementia Recruiting NCT02415062 Phase 2
37 Effects of Tolcapone on Frontotemporal Dementia Active, not recruiting NCT00604591 Phase 2
38 Davunetide (AL-108) in Predicted Tauopathies - Pilot Study Active, not recruiting NCT01056965 Phase 2
39 Phase I/II Pilot Study of Mixed Chimerism to Treat Inherited Metabolic Disorders Active, not recruiting NCT01372228 Phase 1, Phase 2
40 Clinical Trial in Infants With Rapidly Progressive Lysosomal Acid Lipase Deficiency Active, not recruiting NCT02193867 Phase 2
41 Tau PET Imaging With 18F-AV-1451 in Subjects With MAPT Mutations Enrolling by invitation NCT02676843 Phase 2
42 A Long-Term Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency Enrolling by invitation NCT02004704 Phase 2
43 F 18 T807 Tau PET Imaging of Frontotemporal Dementia (FTD) Not yet recruiting NCT02707978 Phase 2
44 Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism Terminated NCT00668564 Phase 2
45 Far Infrared Irradiation for the Management, Control and Treatment of Frontotemporal Dementia Unknown status NCT00674960 Phase 1
46 Far Infrared Radiation Treatment of Dementia and Other Mental Illness Unknown status NCT00574054 Phase 1
47 Clinical and Genetic Study of Neurodegenerative Disorders With Cognitive Impairment Unknown status NCT00149175 Phase 1
48 Safety Study of Intranasal Oxytocin in Frontotemporal Dementia Completed NCT01386333 Phase 1
49 Direct Current Brain Polarization in Frontotemporal Dementia Completed NCT00077896 Phase 1
50 Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease Completed NCT01747135 Phase 1

Search NIH Clinical Center for Semantic Dementia

Genetic Tests for Semantic Dementia

Anatomical Context for Semantic Dementia

MalaCards organs/tissues related to Semantic Dementia:

39
Brain, Temporal Lobe, Testes, Cortex

Publications for Semantic Dementia

Articles related to Semantic Dementia:

(show top 50) (show all 338)
id Title Authors Year
1
Famous faces and voices: Differential profiles in early right and left semantic dementia and in Alzheimer's disease. ( 27916672 )
2017
2
Diverging Progression of Network Disruption and Atrophy in Alzheimer's Disease and Semantic Dementia. ( 27802229 )
2017
3
Regularity and beyond: Impaired production and comprehension of inflectional morphology in semantic dementia. ( 26994740 )
2016
4
Somatic Symptom Disorder in Semantic Dementia: The Role of Alexisomia. ( 27647568 )
2016
5
Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia. ( 26667277 )
2016
6
Integrated PET/MRI imaging of semantic dementia. ( 27381147 )
2016
7
An update on semantic dementia: genetics, imaging, and pathology. ( 27915998 )
2016
8
Distinct neural substrates of affective and cognitive theory of mind impairment in semantic dementia. ( 26998659 )
2016
9
Successful short-term re-learning and generalisation of concepts in semantic dementia. ( 27677318 )
2016
10
Sensitivity of the Wechsler Abbreviated Scale of Intelligence-Second Edition (WASI-II) to the Neurocognitive Deficits Associated with the Semantic Dementia Variant of Frontotemporal Lobar Degeneration: A Case Study. ( 27101084 )
2016
11
Discovering EEG resting state alterations of semantic dementia. ( 27072087 )
2016
12
Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia. ( 27981671 )
2016
13
Atrophy in Alzheimer's Disease andA Semantic Dementia: An ALE Meta-Analysis of Voxel-Based Morphometry Studies. ( 27567843 )
2016
14
Two cases of food aversion with semantic dementia. ( 26963051 )
2016
15
Semantic Dementia: A Mini-Review. ( 28019640 )
2016
16
Amyloid deposition in semantic dementia: a positron emission tomography study. ( 26807731 )
2016
17
The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia. ( 27242479 )
2016
18
Preservation of episodic memory in semantic dementia: The importance of regions beyond the medial temporal lobes. ( 26683384 )
2016
19
On the right side? A longitudinal study of left- versus right-lateralized semantic dementia. ( 26811253 )
2016
20
Prosopagnosia as unusual presentation of semantic dementia: a case study. ( 27489094 )
2016
21
Preservation of Person-Specific Semantic Knowledge in Semantic Dementia: Does Direct Personal Experience Have a Specific Role? ( 26635578 )
2015
22
Mechanical Problem-Solving Strategies in Alzheimer's Disease and Semantic Dementia. ( 26523522 )
2015
23
For richer or poorer? Imageability effects in semantic dementia patients' reading aloud. ( 25804665 )
2015
24
Smartphone for smart living: Using new technologies to cope with everyday limitations in semantic dementia. ( 26483262 )
2015
25
Progressive Supranuclear Palsy Syndrome and Semantic Dementia in Neuropathologically Proven Lewy Body Disease: A Report of Two Cases. ( 26402758 )
2015
26
Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia. ( 26705265 )
2015
27
"Knowing What You Don't Know": Language Insight in Semantic Dementia. ( 25720396 )
2015
28
Relying on procedural memory to enhance independence in daily living activities: Smartphone use in a case of semantic dementia. ( 25558769 )
2015
29
Declining object recognition performance in semantic dementia: A case for stored visual object representations. ( 27355607 )
2015
30
Vocabulary relearning in semantic dementia: Positive and negative consequences of increasing variability in the learning experience. ( 25585251 )
2015
31
Dissociated word production and comprehension in semantic dementia. ( 25987438 )
2015
32
The Brain Connectivity Basis of Semantic Dementia: A Selective Review. ( 26336932 )
2015
33
Restoration of conceptual knowledge in a case of semantic dementia. ( 24592963 )
2014
34
Deregulated semantic cognition contributes to object-use deficits in Alzheimer's disease: A comparison with semantic aphasia and semantic dementia. ( 24909263 )
2014
35
A-25A Case Study of Late Onset Semantic Dementia. ( 25176687 )
2014
36
The anterior temporal lobes are critically involved in acquiring new conceptual knowledge: Evidence for impaired feature integration in semantic dementia. ( 24268323 )
2014
37
Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: an examination of clinical characteristics and emotion processing. ( 25511791 )
2014
38
Right anterior temporal lobe dysfunction underlies theory of mind impairments in semantic dementia. ( 24523434 )
2014
39
TARDBP mutation p.Ile383Val associated with semantic dementia and complex proteinopathy. ( 23692129 )
2014
40
"The mind is its own place": amelioration of claustrophobia in semantic dementia. ( 24825962 )
2014
41
Intrinsic connectivity identifies the hippocampus as a main crossroad between Alzheimer's and semantic dementia-targeted networks. ( 24656258 )
2014
42
Quantitative evaluation of changes in the clock-watching behavior of a patient with semantic dementia. ( 24650896 )
2014
43
Episodic future thinking in semantic dementia: a cognitive and FMRI study. ( 25333997 )
2014
44
Progressive supranuclear palsy presenting initially as semantic dementia. ( 25516053 )
2014
45
The neural correlates of road sign knowledge and route learning in semantic dementia and Alzheimer's disease. ( 25535307 )
2014
46
Cerebellar hyperperfusion in semantic dementia. ( 23414345 )
2014
47
When the zebra loses its stripes but is still in the savannah: Results from a semantic priming paradigm in semantic dementia. ( 24316142 )
2014
48
Characteristics of dyslexia and dysgraphia in a Chinese patient with semantic dementia. ( 24606031 )
2014
49
The undiscovered syndrome: Macdonald Critchley's case of semantic dementia. ( 24818802 )
2014
50
What lies beneath: a comparison of reading aloud in pure alexia and semantic dementia. ( 24702272 )
2014

Variations for Semantic Dementia

Expression for Semantic Dementia

Search GEO for disease gene expression data for Semantic Dementia.

Pathways for Semantic Dementia

Pathways related to Semantic Dementia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.53 APOE MAPT PSEN1 TARDBP TREM2
2 10.82 RPS27A VCP
3 10.79 APOE MAPT PSEN1
4 10.23 RPS27A VCP

GO Terms for Semantic Dementia

Biological processes related to Semantic Dementia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 APOE PSEN1 RPS27A
2 translesion synthesis GO:0019985 9.43 RPS27A VCP
3 viral life cycle GO:0019058 9.37 CHMP2B RPS27A
4 positive regulation of dendritic spine development GO:0060999 9.32 APOE PSEN1
5 error-free translesion synthesis GO:0070987 9.26 RPS27A VCP
6 virion assembly GO:0019068 9.16 APOE RPS27A
7 amyloid precursor protein metabolic process GO:0042982 8.96 APOE PSEN1
8 autophagy GO:0006914 8.92 C9orf72 CHMP2B PSEN1 VCP

Molecular functions related to Semantic Dementia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Semantic Dementia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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