MCID: SMN008
MIFTS: 34

Semantic Dementia malady

Neuronal diseases category

Summaries for Semantic Dementia

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Sources:
43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick?s disease, the name and classification of FTD has been a topic of discussion for over a century.

MalaCards: Semantic Dementia, also known as semantic primary progressive aphasia, is related to dementia and alzheimer's disease. An important gene associated with Semantic Dementia is GRN (granulin), and among its related pathways are Endosomal Sorting Complex Required For Transport (ESCRT) and Alzheimers Disease Pathway. The compounds tacrine and donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are other and cellular.

Wikipedia:63 Semantic dementia (SD) is a progressive neurodegenerative disorder characterized by loss of semantic... more...

Aliases & Classifications for Semantic Dementia

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Sources:
60UMLS, 42NIH Rare Diseases, 43NINDS, 44Novoseek, 48Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
semantic dementia:
Inheritance: Multigenic/multifactorial,Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

semantic dementia 42 43 44 48 60
semantic primary progressive aphasia 42 48
semantic variant ppa 42 48
primary progressive aphasia 60
dementia - semantic 43


External Ids:

SNOMED-CT via Orphanet57 230288001
ICD10 via Orphanet26 G31.0

Related Diseases for Semantic Dementia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Semantic Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.9RPS27A, APOE, MAPT, TARDBP, VCP, PSEN1
2alzheimer's disease31.2RPS27A, APOE, VCP, MAPT, TARDBP, GRN
3frontotemporal dementia31.2PSEN1, MAPT
4aphasia31.1MAPT, TARDBP, GRN, C9orf72
5frontotemporal lobar degeneration with ubiquitin-positive inclusions30.4GRN
6progressive supranuclear palsy30.4APOE, MAPT, RPS27A
7motor neuron disease30.3GRN, RPS27A, MAPT, VCP, TARDBP
8apraxia30.1GRN, MAPT
9pick's disease30.1PSEN1, MAPT
10primary progressive aphasia30.1MAPT, RPS27A, GRN
11tauopathy30.1RPS27A, PSEN1, GRN, MAPT
12dyslexia10.5
13logopenic progressive aphasia10.4
14neuronitis10.4
15cerebritis10.3
16alexia10.2
17transient global amnesia10.2
18agnosia10.2
19progressive non-fluent aphasia10.2
20prosopagnosia10.1
21dysgraphia10.1
22encephalitis10.1
23glucose metabolism disease10.1
24herpes simplex10.1
25ideomotor apraxia10.1
26learning disability10.1
27reading disorder10.1
28lateral sclerosis10.0TARDBP
29vascular dementia10.0APOE
30neuronal intranuclear inclusion disease10.0RPS27A
31myotonic dystrophy10.0MAPT
32pancreatic cancer10.0RPS27A
33scrapie10.0MAPT
34inclusion body myositis10.0RPS27A, MAPT
35spinocerebellar ataxia type 310.0RPS27A, VCP
36myopathy10.0VCP, RPS27A
37multiple system atrophy10.0MAPT, RPS27A
38spinocerebellar ataxia10.0RPS27A, MAPT
39schizophrenia10.0PSEN1
40ischemia10.0MAPT, PSEN1
41movement disease10.0RPS27A, MAPT
42prion disease10.0PSEN1, MAPT
43myositis10.0RPS27A, PSEN1, MAPT
44lewy body dementia10.0MAPT, APOE, RPS27A
45creutzfeldt-jakob syndrome10.0RPS27A, APOE, MAPT
46hemorrhage, intracerebral10.0RPS27A, APOE, PSEN1
47huntington's disease10.0MAPT, RPS27A, PSEN1
48cerebral amyloid angiopathy10.0APOE, PSEN1, MAPT
49alzheimer disease type 210.0PSEN1, MAPT, APOE
50down syndrome10.0PSEN1, APOE, MAPT

Graphical network of the top 20 diseases related to Semantic Dementia:



Diseases related to semantic dementia

Clinical Features for Semantic Dementia

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Drugs & Therapeutics for Semantic Dementia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Semantic Dementia

Search NIH Clinical Center for Semantic Dementia

Search CenterWatch for Semantic Dementia

Genetic Tests for Semantic Dementia

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Anatomical Context for Semantic Dementia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Semantic Dementia:

32
Brain

Animal Models for Semantic Dementia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Semantic Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.8APOE, PSEN1, MAPT
2MP:00053847.6VCP, TARDBP, MAPT, GRN, PSEN1, APOE
3MP:00053867.5VCP, TARDBP, MAPT, GRN, PSEN1, APOE

Publications for Semantic Dementia

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Genetic Variations for Semantic Dementia

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Expression for genes affiliated with Semantic Dementia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Semantic Dementia

Search GEO for disease gene expression data for Semantic Dementia.

Pathways for genes affiliated with Semantic Dementia

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Sources:
53Reactome, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Semantic Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4CHMP2B, RPS27A
29.1MAPT, PSEN1, APOE
38.3TARDBP, MAPT, PSEN1, APOE

Compounds for genes affiliated with Semantic Dementia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Semantic Dementia according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1tacrine44 1111.0MAPT, APOE
2donepezil44 11 2411.9MAPT, APOE
3galantamine44 49 1111.9MAPT, APOE
4fluorochrome449.8MAPT, RPS27A
5guanidine44 11 2411.7MAPT, APOE
6cysteamine44 11 2411.7APOE, RPS27A
7spec-t449.5MAPT, PSEN1, APOE
8vitamin b12449.5APOE, PSEN1, MAPT
9kainate44 2810.5MAPT, PSEN1, APOE
10thioflavine s449.4MAPT, APOE, RPS27A
11folate449.4MAPT, PSEN1, APOE
12formate449.4RPS27A, APOE, MAPT
13chloroquine44 2 49 28 1113.4MAPT, APOE, RPS27A
14sodium dodecylsulfate449.4RPS27A, APOE, MAPT
15glycerol44 11 2411.3RPS27A, PSEN1, MAPT
16n acetylcysteine449.2RPS27A, APOE, MAPT
17biotin44 11 2411.2PSEN1, APOE, RPS27A
18tamoxifen44 49 28 1112.1RPS27A, APOE, GRN
19streptozotocin449.0APOE, RPS27A
20acetylcholine44 49 28 11 2413.0MAPT, APOE, RPS27A
21glycogen44 2410.0MAPT, PSEN1, RPS27A
224-hydroxynonenal44 249.9RPS27A, APOE, PSEN1, MAPT
23lactacystin448.9MAPT, PSEN1, APOE, RPS27A
24valine448.9MAPT, PSEN1, APOE, RPS27A
25nmda44 289.9MAPT, PSEN1, APOE, RPS27A
26threonine448.8VCP, MAPT, PSEN1, RPS27A
27aspartate448.8RPS27A, APOE, PSEN1, MAPT
28cycloheximide448.8RPS27A, APOE, PSEN1, MAPT
29h2o2448.8RPS27A, APOE, PSEN1, MAPT
30arginine448.7RPS27A, APOE, PSEN1, MAPT
31glutamate448.6RPS27A, APOE, PSEN1, MAPT
32alanine448.6MAPT, PSEN1, APOE, RPS27A
33estrogen448.6RPS27A, APOE, GRN, MAPT
34cysteine448.5RPS27A, APOE, PSEN1, GRN, MAPT
35glutamine448.5RPS27A, APOE, PSEN1, MAPT, VCP
36serine448.3VCP, MAPT, PSEN1, APOE, RPS27A

GO Terms for genes affiliated with Semantic Dementia

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Sources:
16Gene Ontology
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Biological processes related to Semantic Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:0324369.6VCP, PSEN1
2positive regulation of axon extensionGO:0457739.5APOE, MAPT
3Notch receptor processingGO:0072209.0PSEN1, RPS27A
4cell deathGO:0082197.9TARDBP, GRN, CHMP2B, C9orf72, APOE

Molecular functions related to Semantic Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.6MAPT, APOE

Products for genes affiliated with Semantic Dementia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Semantic Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet