MCID: SMN008
MIFTS: 37

Semantic Dementia

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Semantic Dementia

MalaCards integrated aliases for Semantic Dementia:

Name: Semantic Dementia 50 51 52 69
Semantic Primary Progressive Aphasia 50
Semantic Variant Ppa 50
Dementia - Semantic 51

Classifications:



Summaries for Semantic Dementia

NINDS : 51 Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick’s disease, the name and classification of FTD has been a topic of discussion for over a century.  The current designation of the syndrome groups together Pick’s disease, primary progressive aphasia, and semantic dementia as FTD.  Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex.  These designations will continue to be debated.  As it is defined today, the symptoms of FTD fall into two clinical patterns that involve either (1) changes in behavior, or (2) problems with language.  The first type features behavior that can be either impulsive (disinhibited) or bored and listless (apathetic) and includes inappropriate social behavior; lack of social tact; lack of empathy; distractability; loss of insight into the behaviors of oneself and others; an increased interest in sex; changes in food preferences; agitation or, conversely, blunted emotions; neglect of personal hygiene; repetitive or compulsive behavior, and decreased energy and motivation.  The second type primarily features symptoms of language disturbance, including difficulty making or understanding speech, often in conjunction with the behavioral type’s symptoms.  Spatial skills and memory remain intact.  There is a strong genetic component to the disease; FTD often runs in families.

MalaCards based summary : Semantic Dementia, also known as semantic primary progressive aphasia, is related to pick disease and dementia, frontotemporal. An important gene associated with Semantic Dementia is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). The drugs Dopamine and Memantine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and temporal lobe, and related phenotype is no phenotypic analysis.

NIH Rare Diseases : 50 this condition doesn't have a summary yet. please see our page(s) on frontotemporal dementia.

Wikipedia : 72 Semantic dementia (SD) is a progressive neurodegenerative disorder characterized by loss of semantic... more...

Related Diseases for Semantic Dementia

Diseases related to Semantic Dementia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Related Disease Score Top Affiliating Genes
1 pick disease 29.1 APOE GRN MAPT RPS27A TARDBP
2 dementia, frontotemporal 11.9
3 frontotemporal lobar degeneration with ubiquitin-positive inclusions 11.1
4 dementia 11.0
5 aphasia 10.4
6 acquired purpura fulminans 10.3 APOE MAPT
7 dyslexia 10.2
8 hyperekplexia, hereditary 1, autosomal dominant or recessive 10.2 MAPT RPS27A
9 basilar impression, primary 10.2 MAPT RPS27A
10 pulmonary systemic sclerosis 10.2 APOE MAPT
11 bladder cancer, childhood 10.2 APOE MAPT
12 limited scleroderma 10.1 APOE MAPT
13 meckel syndrome 10 10.1 APOE MAPT
14 riedel's fibrosing thyroiditis 10.1 MAPT TARDBP
15 urethritis 10.1 APOE TARDBP
16 thyroid dyshormonogenesis 6 10.0 MAPT TARDBP
17 carotid body cancer 10.0 APOE MAPT
18 neuronitis 10.0
19 myoclonic epilepsy associated with ragged-red fibers 10.0 MAPT RPS27A
20 alzheimer disease 10.0
21 alexia 10.0
22 cerebritis 10.0
23 prosopagnosia 10.0
24 corticobasal degeneration 10.0
25 parietal foramina 3 9.9 MAPT RPS27A
26 propriospinal myoclonus 9.9 GRN MAPT
27 isolated focal cortical dysplasia type ic 9.9 GRN MAPT
28 ichthyosis lamellar 1 9.9 APOE MAPT
29 adrenal gland pheochromocytoma 9.9 MAPT RPS27A
30 motor neuron disease 9.9
31 dysgraphia 9.9
32 progressive non-fluent aphasia 9.9
33 akinetic mutism 9.8 APOE GRN
34 simultanagnosia 9.8 GRN TARDBP
35 autotopagnosia 9.8 GRN TARDBP
36 apraxia 9.7
37 agraphia 9.7
38 lateral sclerosis 9.7
39 herpes simplex 9.7
40 encephalitis 9.7
41 developmental prosopagnosia 9.7
42 hyperacusis 9.7
43 posterior cortical atrophy 9.7
44 cough headache 9.7 MAPT RPS27A TARDBP
45 mast syndrome 9.7 MAPT RPS27A TARDBP
46 parkinson disease, late-onset 9.6 APOE MAPT RPS27A
47 melanoma, cutaneous malignant, 2 9.6 GRN TARDBP
48 hepatic angiomyolipoma 9.6 APOE MAPT TARDBP
49 perry syndrome 9.6 GRN TARDBP
50 prion disease with protracted course 9.6 APOE MAPT

Graphical network of the top 20 diseases related to Semantic Dementia:



Diseases related to Semantic Dementia

Symptoms & Phenotypes for Semantic Dementia

MGI Mouse Phenotypes related to Semantic Dementia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.92 APOE GRN MAPT TARDBP

Drugs & Therapeutics for Semantic Dementia

Drugs for Semantic Dementia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 114)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2 19982-08-2 4054
3
Citalopram Approved Phase 4 59729-33-8 2771
4
Corticosterone Experimental Phase 4,Phase 1,Early Phase 1 50-22-6 5753
5
Iodine Investigational Phase 4 7553-56-2 807
6 Fluorodeoxyglucose F18 Phase 4,Phase 2,Phase 1
7 Antiparkinson Agents Phase 4,Phase 3,Phase 2
8 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Excitatory Amino Acid Antagonists Phase 4,Phase 3,Phase 2
10 Excitatory Amino Acids Phase 4,Phase 3,Phase 2
11 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
12 Antidepressive Agents Phase 4,Phase 2,Phase 1
13 Antidepressive Agents, Second-Generation Phase 4
14 Neurotransmitter Uptake Inhibitors Phase 4
15 Psychotropic Drugs Phase 4,Phase 2,Phase 1
16
Serotonin Phase 4 50-67-9 5202
17 Serotonin Agents Phase 4
18 Serotonin Uptake Inhibitors Phase 4
19 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
20 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
21 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
23 Anti-Inflammatory Agents Phase 4,Phase 1
24 Analgesics Phase 4,Phase 1
25 Analgesics, Non-Narcotic Phase 4,Phase 1
26 cadexomer iodine Phase 4
27 Calamus Nutraceutical Phase 4
28
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
29
Miglustat Approved Phase 3,Phase 2,Phase 1 72599-27-0 51634
30
Busulfan Approved, Investigational Phase 2, Phase 3 55-98-1 2478
31
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
32
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
33
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
34
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
35
Iron Approved Phase 2, Phase 3 7439-89-6 23925
36 tannic acid Approved, Nutraceutical Phase 3
37
1-Deoxynojirimycin Experimental Phase 3,Phase 2 19130-96-2 1374
38 Anti-HIV Agents Phase 3,Phase 2,Phase 1
39 Anti-Retroviral Agents Phase 3,Phase 2,Phase 1
40 Cardiac Glycosides Phase 3,Phase 2,Phase 1
41 Glycoside Hydrolase Inhibitors Phase 3,Phase 2,Phase 1
42 Hypoglycemic Agents Phase 3,Phase 2,Phase 1
43 Alkylating Agents Phase 2, Phase 3
44 Antilymphocyte Serum Phase 2, Phase 3
45 Antirheumatic Agents Phase 2, Phase 3,Phase 1
46 Immunosuppressive Agents Phase 2, Phase 3
47 Methylprednisolone acetate Phase 2, Phase 3
48 Methylprednisolone Hemisuccinate Phase 2, Phase 3
49 Prednisolone acetate Phase 2, Phase 3
50 Prednisolone hemisuccinate Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 146)

id Name Status NCT ID Phase Drugs
1 Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia Completed NCT00545974 Phase 4 memantine;Placebo pill
2 Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia Completed NCT00376051 Phase 4 Citalopram
3 Imaging of Brain Amyloid Plaques in the Aging Population Enrolling by invitation NCT00950430 Phase 4 Pittsburgh Compound B (C-11 PiB);F-18 FDG;Tau (18-F-AV-1451)
4 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4 I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
5 Amantadine for the Treatment of Behavioral Disturbance in Frontotemporal Dementia (FTD) Withdrawn NCT00127114 Phase 4 Amantadine;Placebo
6 Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD) Completed NCT01626378 Phase 3 TRx0237;Placebo
7 Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia Completed NCT00594737 Phase 3 memantine hydrochloride
8 Application of Miglustat in Patients With Niemann-Pick Type C Completed NCT01760564 Phase 3 Miglustat
9 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Antithymocyte Globulin
10 Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency Recruiting NCT02004691 Phase 2, Phase 3 placebo (saline);GZ402665
11 Arimoclomol Prospective Study in Patients Diagnosed With NiemannPick Disease Type C Active, not recruiting NCT02612129 Phase 2, Phase 3 arimoclomol;Placebo
12 Study of VTS-270 (2-hydroxypropyl-β-cyclodextrin) to Treat Niemann-Pick Type C1 (NPC1) Disease Active, not recruiting NCT02534844 Phase 2, Phase 3 VTS-270;Sham Procedure Control
13 SurVival of Lysosomal Acid Lipase Deficiency (LAL-D) Infants Treated With SebelipAse aLfa Active, not recruiting NCT01371825 Phase 2, Phase 3 Sebelipase alfa (SBC-102)
14 Open-Label Study of TRx0237 in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD) Enrolling by invitation NCT02245568 Phase 3 TRx0237
15 Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis Not yet recruiting NCT03293069 Phase 2, Phase 3 Deferiprone;Placebo Oral Tablet
16 ALD-101 Adjuvant Therapy of Unrelated Umbilical Cord Blood Transfusion (UCBT) in Patients With Inherited Metabolic Diseases Terminated NCT00654433 Phase 3
17 Children With Lysosomal Acid Lipase Deficiency Who Previously Received Treatment With SBC-102 Terminated NCT01473875 Phase 2, Phase 3 SBC-102
18 Study to Assess the Safety, Tolerability, and Pharmacodynamic (PD) Effects of FRM-0334 in Subjects With Prodromal to Moderate Frontotemporal Dementia With Granulin Mutation Unknown status NCT02149160 Phase 2 FRM-0334;Placebo
19 Phase 1/2 Study of Vorinostat Therapy in Niemann-Pick Disease, Type C1 Completed NCT02124083 Phase 1, Phase 2 Vorinostat
20 A Pilot Study to Explore the Safety and Tolerability of Galantamine HBr in the Treatment of Pick Complex/Frontotemporal Dementia Completed NCT00416169 Phase 2 galantamine hydrobromide
21 Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine Completed NCT00975689 Phase 1, Phase 2 N-Acetyl Cysteine
22 Efficacy and Tolerability of Memantine in Frontotemporal Dementia (FTD) Patients Completed NCT00200538 Phase 2 memantine
23 Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls. Completed NCT01890343 Phase 2 florbetapir 18F;18F-FDG
24 Electroencephalography (EEG) Biofeedback Training to Improve Executive Functioning and Memory in Adults With a Dementing Illness Completed NCT01168466 Phase 2
25 Double Blind Trial of DC Polarization in FTD Completed NCT00117858 Phase 2
26 Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Completed NCT00730314 Phase 1, Phase 2
27 Miglustat in Niemann-Pick Type C Disease Completed NCT00517153 Phase 2 miglustat
28 Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia Recruiting NCT02862210 Phase 2 Lithium Carbonate;Placebo
29 Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia Recruiting NCT01937013 Phase 2 Intranasal oxytocin;Saline Nasal Mist
30 Study of Pharmacokinetics and Preliminary Efficacy in Patients With Niemann-Pick C1 Recruiting NCT02912793 Phase 1, Phase 2 Hydroxypropyl-beta-cyclodextrin
31 Study of Lithium Carbonate to Treat Niemann-Pick Type C1 Disease Recruiting NCT03201627 Phase 1, Phase 2 Lithium Carbonate
32 F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis Recruiting NCT02414230 Phase 2 Drug: F 18 T807
33 Safety, Tolerability, PK, and Efficacy Evaluation of Repeat Ascending Doses of Olipudase Alfa in Pediatric Patients <18 Years of Age With Acid Sphingomyelinase Deficiency Recruiting NCT02292654 Phase 1, Phase 2 Olipudase alfa
34 Effects of Tolcapone on Frontotemporal Dementia Active, not recruiting NCT00604591 Phase 2 Tolcapone;Placebo
35 Davunetide (AL-108) in Predicted Tauopathies - Pilot Study Active, not recruiting NCT01056965 Phase 2 davunetide (AL-108, NAP);Placebo nasal spray
36 Phase I/II Pilot Study of Mixed Chimerism to Treat Inherited Metabolic Disorders Active, not recruiting NCT01372228 Phase 1, Phase 2
37 Clinical Trial in Infants With Rapidly Progressive Lysosomal Acid Lipase Deficiency Active, not recruiting NCT02193867 Phase 2 sebelipase alfa
38 Tau PET Imaging With 18F-AV-1451 in Subjects With MAPT Mutations Enrolling by invitation NCT02676843 Phase 2 18F-AV-1451
39 A Long-Term Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency Enrolling by invitation NCT02004704 Phase 2 GZ402665
40 Intranasal Oxytocin for Frontotemporal Dementia Not yet recruiting NCT03260920 Phase 2 Syntocinon
41 Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism Terminated NCT00668564 Phase 2 Cyclophosphamide;Campath-1H;Busulfan
42 F 18 T807 Tau PET Imaging of Frontotemporal Dementia (FTD) Withdrawn NCT02707978 Phase 2 F 18 T807
43 Far Infrared Irradiation for the Management, Control and Treatment of Frontotemporal Dementia Unknown status NCT00674960 Phase 1
44 Far Infrared Radiation Treatment of Dementia and Other Mental Illness Unknown status NCT00574054 Phase 1
45 Clinical and Genetic Study of Neurodegenerative Disorders With Cognitive Impairment Unknown status NCT00149175 Phase 1
46 Safety Study of Intranasal Oxytocin in Frontotemporal Dementia Completed NCT01386333 Phase 1 oxytocin;Saline Nasal Mist
47 Direct Current Brain Polarization in Frontotemporal Dementia Completed NCT00077896 Phase 1
48 Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease Completed NCT01747135 Phase 1 VTS-270
49 Saccadic Eye Movements in Patients With Niemann-Pick Type C Disease Completed NCT00316498 Phase 1 OGT918
50 Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD Completed NCT01723553 Phase 1 C-11 PiB

Search NIH Clinical Center for Semantic Dementia

Genetic Tests for Semantic Dementia

Anatomical Context for Semantic Dementia

MalaCards organs/tissues related to Semantic Dementia:

39
Brain, Testes, Temporal Lobe, Cortex, Bone, Prefrontal Cortex, Eye

Publications for Semantic Dementia

Articles related to Semantic Dementia:

(show top 50) (show all 347)
id Title Authors Year
1
Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration. ( 28666471 )
2017
2
Semantic word category processing in semantic dementia and posterior cortical atrophy. ( 28624681 )
2017
3
Semantic dementia and the left and right temporal lobes. ( 28947063 )
2017
4
Brain Network for the Core Deficits of Semantic Dementia: A Neural Network Connectivity-Behavior Mapping Study. ( 28579952 )
2017
5
Diverging Progression of Network Disruption and Atrophy in Alzheimer's Disease and Semantic Dementia. ( 27802229 )
2017
6
Rethinking the Cognitive Mechanisms Underlying Pantomime of Tool Use: Evidence from Alzheimer's Disease and Semantic Dementia. ( 28205493 )
2017
7
What semantic dementia teaches us about the functional organization of the left posterior fusiform gyrus. ( 28951166 )
2017
8
Famous faces and voices: Differential profiles in early right and left semantic dementia and in Alzheimer's disease. ( 27916672 )
2017
9
Semantic dementia, progressive non-fluent aphasia and their association with amyotrophic lateral sclerosis. ( 28554960 )
2017
10
A novel prion protein variant in a patient with semantic dementia. ( 28572272 )
2017
11
Topological Alterations and Symptom-Relevant Modules in the Whole-Brain Structural Network in Semantic Dementia. ( 28731453 )
2017
12
An update on semantic dementia: genetics, imaging, and pathology. ( 27915998 )
2016
13
Somatic Symptom Disorder in Semantic Dementia: The Role of Alexisomia. ( 27647568 )
2016
14
On the right side? A longitudinal study of left- versus right-lateralized semantic dementia. ( 26811253 )
2016
15
Two cases of food aversion with semantic dementia. ( 26963051 )
2016
16
Successful short-term re-learning and generalisation of concepts in semantic dementia. ( 27677318 )
2016
17
Regularity and beyond: Impaired production and comprehension of inflectional morphology in semantic dementia. ( 26994740 )
2016
18
Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia. ( 26667277 )
2016
19
Semantic Dementia: A Mini-Review. ( 28019640 )
2016
20
The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia. ( 27242479 )
2016
21
Prosopagnosia as unusual presentation of semantic dementia: a case study. ( 27489094 )
2016
22
Discovering EEG resting state alterations of semantic dementia. ( 27072087 )
2016
23
Sensitivity of the Wechsler Abbreviated Scale of Intelligence-Second Edition (WASI-II) to the Neurocognitive Deficits Associated with the Semantic Dementia Variant of Frontotemporal Lobar Degeneration: A Case Study. ( 27101084 )
2016
24
Atrophy in Alzheimer's Disease andA Semantic Dementia: An ALE Meta-Analysis of Voxel-Based Morphometry Studies. ( 27567843 )
2016
25
Distinct neural substrates of affective and cognitive theory of mind impairment in semantic dementia. ( 26998659 )
2016
26
Amyloid deposition in semantic dementia: a positron emission tomography study. ( 26807731 )
2016
27
Integrated PET/MRI imaging of semantic dementia. ( 27381147 )
2016
28
Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia. ( 27981671 )
2016
29
Preservation of episodic memory in semantic dementia: The importance of regions beyond the medial temporal lobes. ( 26683384 )
2016
30
Preservation of Person-Specific Semantic Knowledge in Semantic Dementia: Does Direct Personal Experience Have a Specific Role? ( 26635578 )
2015
31
Smartphone for smart living: Using new technologies to cope with everyday limitations in semantic dementia. ( 26483262 )
2015
32
For richer or poorer? Imageability effects in semantic dementia patients' reading aloud. ( 25804665 )
2015
33
The Brain Connectivity Basis of Semantic Dementia: A Selective Review. ( 26336932 )
2015
34
Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia. ( 26705265 )
2015
35
"Knowing What You Don't Know": Language Insight in Semantic Dementia. ( 25720396 )
2015
36
Dissociated word production and comprehension in semantic dementia. ( 25987438 )
2015
37
Progressive Supranuclear Palsy Syndrome and Semantic Dementia in Neuropathologically Proven Lewy Body Disease: A Report of Two Cases. ( 26402758 )
2015
38
Mechanical Problem-Solving Strategies in Alzheimer's Disease and Semantic Dementia. ( 26523522 )
2015
39
Declining object recognition performance in semantic dementia: A case for stored visual object representations. ( 27355607 )
2015
40
Relying on procedural memory to enhance independence in daily living activities: Smartphone use in a case of semantic dementia. ( 25558769 )
2015
41
Vocabulary relearning in semantic dementia: Positive and negative consequences of increasing variability in the learning experience. ( 25585251 )
2015
42
Giving Words New Life: Generalization of Word Retraining Outcomes in Semantic Dementia. ( 24413622 )
2014
43
When the zebra loses its stripes but is still in the savannah: Results from a semantic priming paradigm in semantic dementia. ( 24316142 )
2014
44
Characteristics of dyslexia and dysgraphia in a Chinese patient with semantic dementia. ( 24606031 )
2014
45
Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: an examination of clinical characteristics and emotion processing. ( 25511791 )
2014
46
Deregulated semantic cognition contributes to object-use deficits in Alzheimer's disease: A comparison with semantic aphasia and semantic dementia. ( 24909263 )
2014
47
The neural correlates of road sign knowledge and route learning in semantic dementia and Alzheimer's disease. ( 25535307 )
2014
48
Right anterior temporal lobe dysfunction underlies theory of mind impairments in semantic dementia. ( 24523434 )
2014
49
TARDBP mutation p.Ile383Val associated with semantic dementia and complex proteinopathy. ( 23692129 )
2014
50
Cerebellar hyperperfusion in semantic dementia. ( 23414345 )
2014

Variations for Semantic Dementia

Expression for Semantic Dementia

Search GEO for disease gene expression data for Semantic Dementia.

Pathways for Semantic Dementia

Pathways related to Semantic Dementia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.31 APOE MAPT TARDBP
2 11.16 APOE MAPT
3 10.61 APOE MAPT

GO Terms for Semantic Dementia

Biological processes related to Semantic Dementia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 virion assembly GO:0019068 8.62 APOE RPS27A

Molecular functions related to Semantic Dementia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.13 APOE MAPT TARDBP
2 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Semantic Dementia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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