MCID: SMN007
MIFTS: 49

Seminoma malady

Rare diseases, Cancer diseases categories

Summaries for Seminoma

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9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testis or, more... more...

MalaCards: Seminoma, also known as seminoma, pure, is related to germ cell tumors and dysgerminoma. An important gene associated with Seminoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Selected targets of Oct 3 4 and Nicotinate and nicotinamide metabolism. The compounds oestriol and ctp have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and prostate.

Disease Ontology:9 A germinoma that has material basis in cells that make sperm and eggs.

Description from OMIM:48 273300

Aliases & Classifications for Seminoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

seminoma 9 44 11 46 63
seminoma, pure 9


External Ids:

Disease Ontology9 DOID:4440
MeSH36 D018239
NCIt41 C9309
OMIM48 273300

Related Diseases for Seminoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Seminoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1germ cell tumors31.0KIT
2dysgerminoma30.6KIT, ALPP
3germ cell cancer30.6ALPPL2, ALPP
4cryptorchidism30.6ALPP, ALPPL2
5germinoma30.6ALPP, KIT, CGB
6gonadoblastoma30.5KIT, ALPP, ALPPL2
7testicular cancer30.4SSX2, MAGEA4, ALPPL2, ALPP, CGB
8teratoma30.4ALPPL2, ALPP, KIT, CGB, CGB7
9sarcoma30.3CGB, KIT, MAGEA4, SSX2
10embryonal cancer30.1ALPP, ALPPL2
11endodermal sinus tumor30.1CGB, ALPP, ALPPL2
12hypercalcemia29.9ALPPL2, ALPP
13choriocarcinoma29.8ALPPL2, ALPP, CGB, CGB7
14hepatitis b29.8MAGEA4, ALPPL2, ALPP, CGB
15leukemia29.7ALPPL2, ALPP, KIT, CGB
16mediastinitis10.6
17extragonadal seminoma10.5
18testis seminoma10.4
19prostatitis10.3
20testicular microlithiasis10.3
21testicular germ cell tumor10.3
22sertoli cell tumor10.2
23androgen insensitivity syndrome10.2
24gonadal dysgenesis10.2
25spermatocytoma10.2
26klinefelter's syndrome10.2
27mediastinum seminoma10.2
28burns10.1
29orchitis10.1
30tubular variant testicular seminoma10.1
31testicular spermatocytic seminoma10.1
32exophthalmos10.1
33pseudoglandular variant testicular seminoma10.1
34persistent mullerian duct syndrome10.1
35hermaphroditism10.1
36malignant teratoma10.1
37peritonitis10.1
38sarcoidosis10.1
39superior vena cava syndrome10.1
40male germ cell tumor, somatic10.1
41thymus cancer10.1ALPP, KIT
42hypophosphatasia10.1ALPP, ALPPL2
43osteitis fibrosa10.1ALPP, ALPPL2
44osteosclerosis10.1ALPPL2, ALPP
45choledocholithiasis10.1ALPP, ALPPL2
46osteonecrosis10.1ALPPL2, ALPP
47fibrous dysplasia10.1ALPP, ALPPL2
48paget's disease of bone10.1ALPPL2, ALPP
49cholelithiasis10.1ALPPL2, ALPP
50x-linked hypophosphatemia10.1ALPPL2, ALPP

Graphical network of the top 20 diseases related to Seminoma:



Diseases related to seminoma

Symptoms for Seminoma

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48OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Seminoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Seminoma

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Anatomical Context for Seminoma

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34MalaCards
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MalaCards organs/tissues related to Seminoma:

34
Testis, Lymph node, Prostate, Kidney, Pineal, Bone, Spinal cord, Brain, T cells, Testes, Liver, Thyroid, Breast, B cells, Skin, Pancreas, Lung, Heart, Bone marrow

Animal Models for Seminoma or affiliated genes

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Publications for Seminoma

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Sources:
53PubMed
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Articles related to Seminoma:

(show top 50)    (show all 692)
idTitleAuthorsYear
1
A Risk-adapted Study of Cisplatin and Etoposide, with or Without Ifosfamide, in Patients with Metastatic Seminoma: Results of the GETUG S99 Multicenter Prospective Study. (24094847)
2014
2
Seminoma stage 1: Patterns of care in Europe. (23444928)
2013
3
Unilateral seminoma in a dromedary camel. (22646829)
2013
4
Prognostic impact of LDH levels in patients with relapsed/refractory seminoma. (23640062)
2013
5
Stem cell origin of testicular seminoma. (23850550)
2013
6
Disappearance of a major thrombus in the brachiocephalic vein without anticoagulant therapy in a patient with seminoma: A case report. (23671534)
2013
7
An alternative treatment regimen of advanced seminoma with carboplatin, etoposide, and bleomycin instead of cisplatin-based therapy. (21458311)
2013
8
Utility of serum tumor markers during surveillance for stage I seminoma. (22517478)
2012
9
Late recurrence of a seminoma of the testis with a poorly differentiated neuroendocrine carcinoma component. (22084429)
2012
10
Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ERI+36 induction. (22138413)
2012
11
A large advanced seminoma in an older woman with androgen insensitivity syndrome. (22384429)
2011
12
TGF-I^1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma. (21649665)
2011
13
Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types. (21642359)
2011
14
Can radiotherapy be a viable salvage treatment option for the relapsed seminoma confined to the infra-diaphragm region recurring after primary chemotherapy for bulky stage II seminoma? (20944793)
2010
15
Increased expression of urokinase plasminogen activator and its cognate receptor in human seminomas. (20403162)
2010
16
Cytogenetic follow-up in testicular seminoma patients exposed to adjuvant radiotherapy. (20698117)
2010
17
Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas. (19023884)
2009
18
Relapse with malignant transformation after chemotherapy for primary mediastinal seminoma: case report. (19395465)
2009
19
Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: a case report. (18773441)
2008
20
The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma. (18207171)
2008
21
Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. (18936476)
2008
22
Cold agglutinin disease revealing mediastinal seminoma. (17449873)
2007
23
Novel germ cell markers characterize testicular seminoma and fetal testis. (17785371)
2007
24
Complete response after treatment with imatinib in pretreated disseminated testicular seminoma with overexpression of c-KIT. (17976614)
2007
25
Increased human chorionic gonadotropin due to hypogonadism after treatment of a testicular seminoma. (17644799)
2007
26
Stage I seminoma. (17202824)
2006
27
Unilateral seminoma with multiple visceral metastases in a duck (Anas platyrhynchos). (16854647)
2006
28
Testicular seminoma associated with massive necrosis. (16984568)
2006
29
Long-term results of radiotherapy for early-stage testicular seminoma. (15803003)
2005
30
Long-term results of para-aortic irradiation for patients with stage I seminoma of the testis. (15708252)
2005
31
Aspiration cytology of mediastinal seminoma: report of a case with emphasis on the diagnostic role of aspiration cytology, cell block and immunocytochemistry. (16450911)
2005
32
Long-term results in patients affected by testicular seminoma treated with radiotherapy: risk of second malignancies. (15948542)
2005
33
Retroperitoneal seminoma with 'burned out' phenomenon in the testis. (15661068)
2005
34
Fertility in men after treatment for stage 1 and 2A seminoma. (15577436)
2004
35
Seminoma and a gonadoblastoma in an infant with mixed gonadal dysgenesis. (12915842)
2003
36
The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma. (12605640)
2003
37
Testicular seminoma: a clinicopathologic and immunohistochemical study of 105 cases with special reference to seminomas with atypical features. (11927966)
2002
38
Effect of hypoxia on human seminoma cells. (11956589)
2002
39
Extragonadal seminoma after renal transplantation and immunosuppression; treatment in the presence of renal dysfunction: a case report and literature review. (11917946)
2001
40
Cytokeratin expression in seminoma of the human testis. (10761461)
2000
41
Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning. (9823315)
1998
42
Placental alkaline phosphatase in patients with seminoma measured by ELISA as compared to RIA. (9491665)
1997
43
Simultaneous presentation of pineal germinoma and testicular seminoma. (8977797)
1996
44
Mesenteric desmoid tumor 19 years after radiation therapy for testicular seminoma. (7974887)
1994
45
Testicular microlithiasis and seminoma. (8280236)
1993
46
Immunopathology of alkaline phosphatase isozymes in seminoma. (8434423)
1993
47
Placental-like alkaline phosphatase and DNA flow cytometry in spermatocytic seminoma. (1310437)
1992
48
Seminoma of the testis in a patient with 48,XXYY variant of Klinefelter's syndrome. (2052972)
1991
49
Fine-needle aspiration biopsy of seminoma and dysgerminoma: cytologic, histologic, and electron microscopic correlations. (2159868)
1990
50
Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene. (2834730)
1988

Variations for Seminoma

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Expression for genes affiliated with Seminoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seminoma

Search GEO for disease gene expression data for Seminoma.

Pathways for genes affiliated with Seminoma

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51PathCards, 13EMD Millipore, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters
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Pathways related to Seminoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CGB7, CGB
2
Show member pathways
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde39
NAD salvage39
NAD metabolism61
8.8ALPI, ALPP, ALPPL2
38.8ALPI, ALPP, ALPPL2

Compounds for genes affiliated with Seminoma

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46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Seminoma according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1oestriol4610.1CGB7, CGB
2ctp4610.1CGB7, CGB
3vas-a469.9DAZL, ALPPL2, KIT
4levamisole46 1210.9ALPP, ALPPL2
5methotrexate52 46 1211.8CGB7, CGB, KIT
6thyroxine46 2510.6ALPP, CGB, CGB7
7Isopropyl alcohol259.6ALPI, ALPPL2
8Propyl alcohol259.5ALPI, ALPPL2
9Isobutanol259.5ALPPL2, ALPI
101-Pentanol259.5ALPPL2, ALPI
111-Hexanol259.5ALPPL2, ALPI
12phosphoethanolamine469.5ALPP, ALPI
131-Butanol259.5ALPPL2, ALPI
14p-nitrophenyl phosphate469.5ALPP, ALPI
15paraffin469.3ALPPL2, ALPP, KIT
16lactate469.3CGB7, CGB, KIT, ALPP
17cellulose acetate469.3ALPI, ALPP
18testosterone46 62 25 1212.3ALPP, KIT, CGB, CGB7
197,8-dihydroneopterin46 2510.2ALPI, ALPP, ALPPL2
20dihydroneopterin triphosphate46 2510.1ALPPL2, ALPP, ALPI
21dihydroxyacetone46 2510.1ALPPL2, ALPP, ALPI
224-Nitrophenol259.1ALPPL2, ALPP, ALPI
23hydroxyapatite469.1ALPI, ALPP
24Dihydroxyacetone phosphate259.1ALPI, ALPP, ALPPL2
25cisplatin46 52 62 1212.1ALPP, GTF2H2, CGB, CGB7
26cysteine468.9CGB7, CGB, KIT, ALPP
27butyrate468.9ALPI, ALPP, ALPPL2
28guanidine hydrochloride468.8ALPI, ALPP
29Phosphate258.8ALPI, ALPP, ALPPL2
30zinc46 259.6SSX2, DNMT3L, ALPI, GTF2H2

GO Terms for genes affiliated with Seminoma

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17Gene Ontology
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Cellular components related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:0312258.8ALPI, ALPP, ALPPL2

Biological processes related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:0072839.6KIT, DNMT3L, DAZL
2dephosphorylationGO:0163118.5ALPI, ALPP, ALPPL2

Molecular functions related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:0040358.8ALPI, ALPP, ALPPL2

Products for genes affiliated with Seminoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Seminoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet