Aliases & Classifications for Seminoma

MalaCards integrated aliases for Seminoma:

Name: Seminoma 12 72 51 41 14 69
Seminoma, Pure 12

Classifications:



Summaries for Seminoma

Disease Ontology : 12 A germinoma that has material basis in cells that make sperm and eggs.

MalaCards based summary : Seminoma, also known as seminoma, pure, is related to testicular seminoma and testicular germ cell tumor. An important gene associated with Seminoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Peptide hormone metabolism and Cardiac Progenitor Differentiation. The drugs Granisetron and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 72 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

Related Diseases for Seminoma

Diseases related to Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 testicular seminoma 34.3 CGA CGB3 TSPY1
2 testicular germ cell tumor 33.5 AFP ESR2 KIT
3 extragonadal seminoma 32.8 AFP KIT POU5F1 TNFRSF8
4 spermatocytoma 31.9 KIT MAGEA4
5 nonseminomatous germ cell tumor 31.8 AFP CGB5 CGB7
6 embryonal carcinoma 31.4 AFP IGF2 KIT POU5F1 TNFRSF8
7 gonadoblastoma 30.6 ALPPL2 KIT TSPY1
8 cryptorchidism, unilateral or bilateral 30.6 ALPPL2 CGA CGB5
9 endodermal sinus tumor 30.1 AFP ALPP CGB3
10 complete androgen insensitivity syndrome 30.0 ALPPL2 CGA IGF2
11 malignant teratoma 29.9 AFP ENO2 POU5F1
12 mixed germ cell tumor 29.7 AFP CGA CGB3 KIT
13 teratoma 29.6 AFP CGA CGB3 ENO2 KIT POU5F1
14 mature teratoma 29.5 AFP POU5F1
15 malignant sertoli cell tumor 29.4 AFP CGB5 ENO2
16 testicular cancer 29.3 AFP ALPP CGA CGB3 CGB5 MAGEA4
17 intratubular embryonal carcinoma 29.0 AFP KIT POU5F1 TNFRSF8
18 choriocarcinoma 28.9 ALPP ALPPL2 CGA CGB3 CGB5 CGB7
19 testis seminoma 12.1
20 testicular spermatocytic seminoma 12.0
21 mediastinum seminoma 11.9
22 tubular variant testicular seminoma 11.9
23 cribriform variant testicular seminoma 11.9
24 pseudoglandular variant testicular seminoma 11.9
25 mixed germ cell cancer 10.9
26 ovarian mixed germ cell neoplasm 10.5 AFP CGA
27 polyembryoma 10.5 AFP CGA
28 hepatic angiomyolipoma 10.5 AFP KIT
29 central nervous system germinoma 10.5 ALPP POU5F1
30 testicular malignant germ cell cancer 10.5 AFP ALPP
31 tuberculous epididymitis 10.5 AFP CGB3
32 small intestine leiomyosarcoma 10.5 IGF2 KIT
33 small intestinal sarcoma 10.5 IGF2 KIT
34 central nervous system germ cell tumor 10.4 AFP POU5F1
35 embryonal testis carcinoma 10.4 AFP POU5F1
36 chromosomal triplication 10.4 AFP CGA CGB3
37 corpus luteum cyst 10.4 AFP CGB5
38 mixed type thymoma 10.4 KIT PDPN
39 epithelioid trophoblastic tumor 10.4 CGB3 INHA
40 brain germinoma 10.4 AFP KIT POU5F1
41 sacrococcygeal teratoma 10.4 AFP CGA CGB7
42 mediastinitis 10.4
43 triploidy 10.4 AFP CGA CGB7
44 pediatric ovarian germ cell tumor 10.4 ALPP ENO2
45 anorchia 10.3 CGA CGB5
46 pediatric ovarian dysgerminoma 10.3 ALPP ENO2
47 cutaneous ganglioneuroma 10.3 ENO2 KIT
48 orofaciodigital syndrome viii 10.3 AFP CGA INHA
49 aggressive digital papillary adenocarcinoma 10.3 KIT PDPN
50 melanotic medulloblastoma 10.3 AFP ENO2

Graphical network of the top 20 diseases related to Seminoma:



Diseases related to Seminoma

Symptoms & Phenotypes for Seminoma

GenomeRNAi Phenotypes related to Seminoma according to GeneCards Suite gene sharing:

25 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 10 IGF2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 10 CGB3 CGB5 CGB7 IGF2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 10 IGF2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 10 CGB3 CGB5 CGB7
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 10 CGB3 CGB5 CGB7
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 10 IGF2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 10 CGB3 CGB5 CGB7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 10 IGF2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 10 IGF2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10 IGF2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 10 CGB3 CGB5 CGB7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.5 CGB3 CGB5 CGB7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.5 POU5F1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.5 POU5F1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.5 POU5F1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.5 POU5F1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.5 CGB3 CGB5 CGB7 POU5F1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.5 CGB3 CGB5 CGB7
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.5 POU5F1

MGI Mouse Phenotypes related to Seminoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 ESR2 IGF2 INHA KIT MMP16 PDPN
2 liver/biliary system MP:0005370 9.17 AFP ESR2 IGF2 INHA KIT POU5F1

Drugs & Therapeutics for Seminoma

Drugs for Seminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
2
Bleomycin Approved, Investigational Phase 2, Phase 3 11056-06-7 5360373
3
Cisplatin Approved Phase 2, Phase 3, Phase 1 15663-27-1 2767 441203 84093
4
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
5
Lenograstim Approved, Investigational Phase 2, Phase 3, Phase 1 135968-09-1
6
Paclitaxel Approved, Vet_approved Phase 2, Phase 3, Phase 1 33069-62-4 36314
7
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
8
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
9
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
10
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
11
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
12
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
13
Captopril Approved Phase 3 62571-86-2 44093
14
Palivizumab Approved, Investigational Phase 3 188039-54-5
15
Ribavirin Approved Phase 3 36791-04-5 37542
16
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
17
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
18
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
19
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
20
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
21
Ondansetron Approved Phase 3 99614-02-5 4595
22
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
23
Promethazine Approved, Investigational Phase 3 60-87-7 4927
24
Vinblastine Approved Phase 3 865-21-4 241903 13342
25 Antiemetics Phase 3,Phase 2
26 Autonomic Agents Phase 3,Phase 2
27 Gastrointestinal Agents Phase 3,Phase 2
28 Neurotransmitter Agents Phase 3
29 Peripheral Nervous System Agents Phase 3,Phase 2
30
Serotonin Phase 3 50-67-9 5202
31 Serotonin Agents Phase 3
32 Serotonin Antagonists Phase 3
33 Albumin-Bound Paclitaxel Phase 2, Phase 3, Phase 1
34 Anti-Bacterial Agents Phase 2, Phase 3
35 Antibiotics, Antitubercular Phase 2, Phase 3
36 Antimitotic Agents Phase 2, Phase 3, Phase 1
37 Antineoplastic Agents, Phytogenic Phase 2, Phase 3, Phase 1
38 Etoposide phosphate Phase 2, Phase 3
39 Topoisomerase Inhibitors Phase 2, Phase 3
40 Alkylating Agents Phase 3,Phase 1,Phase 2
41 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
42 Anti-Infective Agents Phase 3,Phase 1,Phase 2
43 Antimetabolites Phase 3,Phase 1,Phase 2
44 Antiviral Agents Phase 3,Phase 1,Phase 2
45 Hormone Antagonists Phase 3,Phase 2,Phase 1
46 Hormones Phase 3,Phase 2,Phase 1
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
48 Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
49 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
50 Antineoplastic Agents, Hormonal Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 55)

# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
2 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
5 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
6 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
7 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
8 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
9 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
10 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
11 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
12 Ondansetron With or Without Dexamethasone to Prevent Vomiting in Patients Receiving Radiation Therapy to the Upper Abdomen Completed NCT00016380 Phase 3 dexamethasone;ondansetron
13 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
14 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
15 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
16 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
17 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
18 ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Completed NCT01055067 Phase 2 Tivantinib (ARQ 197)
19 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
20 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
21 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
22 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
23 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
24 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
25 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
26 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
27 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
28 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
29 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
30 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
31 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
32 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
33 Therapy De-escalation in Seminoma Stage IIA/B Recruiting NCT01593241 Phase 2 Carboplatin
34 Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
35 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
36 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
37 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
38 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
39 Carboplatin AUC-10 for Metastatic Seminoma With IGCCCG Good Prognosis Disease-Therapy Directed by Initial Metabolic Response on PET-CT Active, not recruiting NCT02272816 Phase 2 Carboplatin AUC-10
40 Proton Radiotherapy for Stage I, IIA, and IIB Seminoma Active, not recruiting NCT01557790 Phase 2
41 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
42 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
43 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
44 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
45 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
46 REtrospective Study of TESTIcular CAncer Patients at the University Magdeburg Completed NCT02092740
47 Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients Completed NCT00705094
48 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045
49 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021
50 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465

Search NIH Clinical Center for Seminoma

Cochrane evidence based reviews: seminoma

Genetic Tests for Seminoma

Anatomical Context for Seminoma

MalaCards organs/tissues related to Seminoma:

38
Testis, Bone, Bone Marrow, Lymph Node, Liver, Prostate, Kidney

Publications for Seminoma

Articles related to Seminoma:

(show top 50) (show all 891)
# Title Authors Year
1
Controversies in the Management of Clinical Stage I Seminoma: Carboplatin a Decade in-Time to Start Backing Out. ( 29389229 )
2018
2
Seminoma Metastatic to the Orbit. ( 29334543 )
2018
3
Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma. ( 29197138 )
2018
4
Paratesticular seminoma: echographic features and histological diagnosis with review of the literature. ( 29411910 )
2018
5
Metastatic "Burned Out" Seminoma Causing Neurological Paraneoplastic Syndrome-Not Quite "Burned Out". ( 29441039 )
2018
6
Current Practice Patterns Surrounding Fertility Concerns in Stage I Seminoma Patients: Survey of United States Radiation Oncologists. ( 29336660 )
2018
7
Testicular seminoma: Scattered radiation dose to the contralateral testis in the modern era. ( 29306641 )
2018
8
Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy. ( 28367345 )
2017
9
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma. ( 28977870 )
2017
10
Recommendations for followup of stage I and II seminoma: The Princess Margaret Cancer Centre approach. ( 29381453 )
2017
11
Testicle, Seminoma ( 28846234 )
2017
12
Primary mediastinal seminoma presenting with superior vena caval obstruction. ( 28855218 )
2017
13
An unusual case of sudden unexpected death due to massive hemopericardium from primary mediastinal seminoma. ( 28341006 )
2017
14
Mediastinal seminoma presenting with superior vena cava syndrome. ( 28596199 )
2017
15
Re: Testicular Seminoma Clinical Stage 1: Treatment Outcome on a Routine Care Level. ( 28817914 )
2017
16
Spermatocytic Seminoma with Brain Metastasis. ( 27815811 )
2017
17
Testicular seminoma: Are clinical features and treatment outcomes any different in India? ( 29199728 )
2017
18
Seminoma in Undescended Testis Presenting as Metastatic Enlarged Cervical Lymph Nodes. ( 29132494 )
2017
19
Pirfenidone as salvage treatment for refractory bleomycin-induced lung injury: a case report of seminoma. ( 28784103 )
2017
20
Spontaneous regression of anterior mediastinal seminoma with normalization of I^-human chorionic gonadotropin levels. ( 28854409 )
2017
21
Burned-out seminoma revealed by solitary rib bone metastasis. ( 28634622 )
2017
22
Testicular seminoma: oncologic rationale and role of surgery in treatment. ( 28949942 )
2017
23
DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas. ( 28302141 )
2017
24
Pure Testicular Seminoma with Non-Pathologic Elevation of Alpha Fetoprotein: A Case Series. ( 28668957 )
2017
25
Synchronous Hodgkin's lymphoma and seminoma: a rare coexistence and an important lesson. ( 29026566 )
2017
26
Salvage Treatment Options for Recurrent Seminoma? ( 29280438 )
2017
27
Long-term cardiovascular complications in stage I seminoma patients. ( 28852960 )
2017
28
Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells. ( 28459202 )
2017
29
Mediastinal seminoma associated with multilocular thymic cyst. ( 28054283 )
2017
30
Testicular Tumour Size and Rete Testis Invasion as Prognostic Factors for the Risk of Relapse of Clinical Stage I Seminoma Testis Patients Under Surveillance: a Systematic Review by the Testicular Cancer Guidelines Panel. ( 29100813 )
2017
31
FDG PET/CT Image of Seminoma in Androgen Insensitivity Syndrome. ( 28604478 )
2017
32
Anaplastic lymphoma kinase positive large B-cell lymphoma: Literature review and report of an endoscopic fine needle aspiration case with tigroid backgrounds mimicking seminoma. ( 27686567 )
2017
33
Identification of novel genetic etiology and key molecular pathways for seminoma via network-based studies. ( 28791339 )
2017
34
Re: Outcome of Men with Relapse after Adjuvant Carboplatin for Clinical Stage I Seminoma. ( 28817915 )
2017
35
Outcome of Men With Relapse After Adjuvant Carboplatin for Clinical Stage I Seminoma. ( 27893332 )
2017
36
Intra-scrotal testicular torsion of a classical seminoma in an elderly patient: a case report and literature review. ( 28775840 )
2017
37
Testicular Seminoma. ( 28160884 )
2017
38
Spermatocytic Seminoma: A Report of 85 Cases Emphasizing its Morphologic Spectrum Including Some Aspects not Widely Known. ( 29280854 )
2017
39
A case of seminoma presented with clinical manifestations of testicular torsion. ( 28969409 )
2017
40
Appendix 9: Testicular seminoma and non-seminoma: eUpdate published online 29 June 2017 (www.esmo.org/Guidelines/Genitourinary-Cancers). ( 28881930 )
2017
41
Testicular Seminoma and Its Mimics: From the Radiologic Pathology Archives. ( 28574809 )
2017
42
An Uncommon Presentation of a Metachronous Testicular Primary Nonseminoma and Seminoma Separated by Two Decades and a Testicular Cancer Literature Review. ( 29070998 )
2017
43
Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation. ( 28218476 )
2017
44
Patterns of care and survival outcomes for adolescent and young adult patients with testicular seminoma in the United States: A National Cancer Database analysis. ( 28153774 )
2017
45
Orchitis reveals an extragonadal primary mediastinal thymic seminoma: a coincidence or not? ( 28407803 )
2017
46
Re: Interim (18)F-Fluorodeoxyglucose Positron Emission Tomography for Early Metabolic Assessment of Response to Cisplatin, Etoposide, and Bleomycin Chemotherapy for Metastatic Seminoma: Clinical Value and Future Directions. ( 28618675 )
2017
47
Changing Practice Evaluation-Stage 1 Seminoma: Outcomes With Adjuvant Treatment Versus Surveillance: Risk Factors for Recurrence and Optimizing Follow-up Protocols-Experience From a Supraregional Center. ( 29336917 )
2017
48
Prognostic factors for tumor recurrence in patients with clinical stage I seminoma undergoing surveillance-A systematic review. ( 28712790 )
2017
49
A case of highly aggressive anaplastic seminoma of the testis presenting as fungating scrotal lesion. ( 28679192 )
2017
50
First reported case of paratesticular seminoma in a postpubertal cryptorchid testis. ( 28698791 )
2017

Variations for Seminoma

Copy number variations for Seminoma from CNVD:

7 (show all 13)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 55928 11 56400000 134452384 Loss Seminomas
2 61576 12 1 56300000 Gain Seminomas
3 119165 18 1 15400000 Loss Seminomas
4 120979 18 35500000 76117153 Loss Seminomas
5 138723 2 169500000 182700000 Gain Seminomas
6 146936 2 56300000 182700000 Loss Seminomas
7 157118 21 12300000 46944323 Gain Seminomas
8 160299 22 11800000 49691432 Loss Seminomas
9 217037 7 1 158821424 Gain Seminomas
10 237233 8 2200000 146274826 Gain Seminomas
11 257126 X 1 24900000 Gain Seminomas
12 262546 X 37500000 154913754 Gain Seminomas
13 262571 X 37500000 47300000 Gain Seminomas

Expression for Seminoma

Search GEO for disease gene expression data for Seminoma.

GO Terms for Seminoma

Cellular components related to Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 AFP ALPPL2 CGA CGB3 CGB5 CGB7

Biological processes related to Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.92 CGA CGB3 CGB5 CGB7 ESR2 INHA
2 regulation of receptor activity GO:0010469 9.73 CGA CGB3 CGB5 CGB7 IGF2 INHA
3 peptide hormone processing GO:0016486 9.33 CGA CGB3 CGB5
4 female gamete generation GO:0007292 9.13 CGB3 CGB5 CGB7
5 cell-cell signaling GO:0007267 9.1 CGA CGB3 CGB5 CGB7 ESR2 INHA

Molecular functions related to Seminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 9.16 KIT POU5F1
2 hormone activity GO:0005179 9.02 CGA CGB3 CGB7 IGF2 INHA
3 alkaline phosphatase activity GO:0004035 8.96 ALPP ALPPL2

Sources for Seminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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