MCID: SMN007
MIFTS: 48

Seminoma malady

Summaries for Seminoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testis or, more... more...

MalaCards: Seminoma, also known as seminoma, pure, is related to testicular cancer and gonadoblastoma. An important gene associated with Seminoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Selected targets of Oct-3/4 and NAD metabolism. The compounds paraffin and lactate have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and prostate.

Description from OMIM:46 273300

Aliases & Classifications for Seminoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM
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Aliases & Descriptions:

seminoma 8 42 10 44 60
seminoma, pure 8


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Disease Ontology8 DOID:4440
MeSH34 D018239
NCIt39 C9309
OMIM46 273300

Related Diseases for Seminoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Seminoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1testicular cancer30.7AFP, ALPP
2gonadoblastoma30.3KIT, ALPP, ALPPL2
3sertoli cell tumor30.3ALPP
4sarcoma30.2CGB, SSX2, MAGEA1, MAGEA4, KIT
5male germ cell tumor, somatic30.1DNMT3L, SLC2A6
6embryonal cancer29.9ALPPL2, ALPP, AFP
7endodermal sinus tumor29.9AFP
8squamous cell carcinoma29.9ALPP, MAGEA4, MAGEA1, CGB, CGB7
9hepatitis29.9AFP, MAGEA1, ALPP
10choriocarcinoma29.7ALPPL2, ALPP, AFP, CGB, CGB7
11hepatitis b29.7ALPPL2, ALPP, MAGEA4, MAGEA1, AFP, CGB
12adenocarcinoma29.7CGB7, CGB, AFP, MAGEA1, MAGEA4
13leukemia29.7ALPPL2, ALPP, TCL1A, KIT, MAGEA1, CGB
14hypercalcemia29.7ALPP, ALPPL2
15testis seminoma10.7
16mediastinitis10.6
17extragonadal seminoma10.5
18cryptorchidism10.3
19mediastinum seminoma10.3
20prostatitis10.3
21androgen insensitivity syndrome10.2
22testicular spermatocytic seminoma10.2
23gonadal dysgenesis10.2
24in situ carcinoma10.2
25spermatocytoma10.2
26klinefelter's syndrome10.1
27intratubular embryonal carcinoma10.1
28burns10.1
29exophthalmos10.1
30orchitis10.1
31tubular variant testicular seminoma10.1
32pseudoglandular variant testicular seminoma10.1
33malignant sertoli cell tumor10.1
34persistent mullerian duct syndrome10.1
35hermaphroditism10.1
36malignant teratoma10.1
37peritonitis10.1
38sarcoidosis10.1
39breast cancer10.0CGB7, CGB, SSX2, MAGEA1, MAGEA4, KIT
40teratoma10.0CGB7, CGB, AFP, KIT, ALPP, ALPPL2
41germinoma10.0CGB, AFP, KIT, ALPP
42myeloma10.0MAGEA1, TCL1A, ALPP, ALPPL2
43cholangiocarcinoma10.0ALPPL2, ALPP, AFP, CGB
44ovarian cancer10.0CGB, AFP, SSX2, MAGEA1
45dysgerminoma10.0ALPP, KIT, AFP
46gestational trophoblastic neoplasm10.0CGB7, CGB, ALPP
47liver cirrhosis10.0AFP, MAGEA1, MAGEA4, ALPP
48germ cell cancer10.0AFP, ALPP, ALPPL2
49hypophosphatasia10.0ALPP, ALPPL2
50synovial sarcoma10.0SSX2, MAGEA1, KIT

Graphical network of the top 20 diseases related to Seminoma:



Diseases related to seminoma

Clinical Features for Seminoma

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46OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Seminoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Seminoma

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Anatomical Context for Seminoma

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32MalaCards
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MalaCards organs/tissues related to Seminoma:

32
Testis, Lymph node, Prostate, Kidney, Pineal, Bone, T cells, Testes, Spinal cord, Brain, Liver, Lung, Breast, Thyroid, Heart, B cells, Pancreas, Skin, Bone marrow

Animal Models for Seminoma or affiliated genes

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Publications for Seminoma

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50PubMed
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Articles related to Seminoma:

(show top 50)    (show all 698)
idTitleAuthorsYear
1
Disappearance of a major thrombus in the brachiocephalic vein without anticoagulant therapy in a patient with seminoma: A case report. (23671534)
2013
2
Genome damage in testicular seminoma patients seven years after radiotherapy. (23859470)
2013
3
An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism. (23626723)
2013
4
Commentary on "patterns of care in the management of seminoma stage I: results from a European survey." Vossen CY, Horwich A, Daugaard G, Vossen CY, Horwich A, Daugaard G, van Poppel H, Osanto S, Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands: BJU Int 2012;110:524. (23465479)
2013
5
Spermatocytic seminoma with sarcoma: an indication for adjuvant chemotherapy in localized disease. (24363873)
2013
6
Rhabdomyosarcomatous differentiation in a spermatocytic seminoma with review of literature. (23449985)
2012
7
Radiation-induced spinal cord anaplastic astrocytoma subsequent to radiotherapy for testicular seminoma. (23006885)
2012
8
Adjuvant radiation therapy for early stage seminoma: proton versus photon planning comparison and modeling of second cancer risk. (22391053)
2012
9
Unusual systemic metastases of malignant seminoma in a dog. (22044725)
2012
10
Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells. (22489004)
2012
11
Estrogen receptor beta (ERI^) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. (22810004)
2012
12
Patterns of care in the management of seminoma stage I: results from a European survey. (22409585)
2012
13
SEOM clinical guidelines for diagnosis and treatment of testicular seminoma (2010). (21821490)
2011
14
Spermatocytic seminoma at the National Institute of Oncology in Morocco. (21714871)
2011
15
Can radiotherapy be a viable salvage treatment option for the relapsed seminoma confined to the infra-diaphragm region recurring after primary chemotherapy for bulky stage II seminoma? (20944793)
2010
16
Primary retroperitoneal seminoma: an unusual cause of testicular pain. (21234135)
2010
17
Giant intra-abdominal seminoma. (19271081)
2009
18
The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma. (18207171)
2008
19
Re: The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma: S. Hinz, M. Schrader, C. Kempkensteffen, R. Bares, W. Brenner, S. Krege, C. Franzius, S. Kliesch, R. Heicappel, K. Miller and M. De Wit J Urol 2008; 179: 936-940. (18951564)
2008
20
A case of synchronous bilateral testicular seminoma. (18521105)
2008
21
Reg I protein in healthy and seminoma human testis. (18712671)
2008
22
Seminoma with conspicuous signet ring cells: a rare, previously uncharacterized morphologic variant. (18580681)
2008
23
Seminoma in undescended testis. (17401599)
2008
24
Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors. (18622385)
2008
25
Management of testicular seminoma with elevation of alpha fetoprotein. A case report]. (18472076)
2008
26
Effect of radiotherapy volume and dose on secondary cancer risk in stage I testicular seminoma. (18164856)
2008
27
Testicular seminoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. (17491040)
2007
28
Population based incidence and age distribution of spermatocytic seminoma. (17499277)
2007
29
Both-sided intra-atrial intracardiac metastases as the initial presentation of testicular seminoma. (17591609)
2007
30
Sonographically documented stable seminoma: a case report. (17333512)
2007
31
A risk-adapted approach to the treatment of stage I seminoma. (16691233)
2006
32
A case of seminoma with a low level positive of serum hCG (human chorionic gonadotropin) beta considered as false positive hCGbeta]. (17025215)
2006
33
Metastatic spermatocytic seminoma--an extremely rare disease. (16314036)
2006
34
Long-term results of radiotherapy for early-stage testicular seminoma. (15803003)
2005
35
Aspiration cytology of mediastinal seminoma: report of a case with emphasis on the diagnostic role of aspiration cytology, cell block and immunocytochemistry. (16450911)
2005
36
Cyclophosphamide-induced cardiomyopathy in a patient with seminoma and a history of mediastinal irradiation. (15750271)
2005
37
No predictive value of beta-hCG in patients with stage I seminoma--results of a long-term follow-up study after adjuvant radiotherapy. (16033057)
2005
38
Postchemotherapy residual masses in advanced seminoma: current management and outcomes. (16221056)
2005
39
Metastatic seminoma with cervical lymphadenopathy as the initial manifestation. (15195884)
2004
40
Healthy girl born after cryopreservation of gametes and ICSI in a patient with seminoma. (15670407)
2004
41
Seminoma nine years after cardiac transplantation. (15167612)
2004
42
Seminoma--a unique case of tumor located in the head of epididymis. (15783112)
2004
43
A case of bilateral seminoma in the setting of persistent mullerian duct syndrome. (11421115)
2001
44
Fine-needle aspiration cytology of a mediastinal seminoma associated with multilocular thymic cyst. (10204106)
1999
45
Simultaneous presentation of pineal germinoma and testicular seminoma. (8977797)
1996
46
Significance of placental alkaline phosphatase (PLAP) in the monitoring of patients with seminoma. (8653285)
1996
47
Heterogeneity in the in vitro survival and proliferation of human seminoma cells. (7529524)
1995
48
Spermatocytic seminoma: an immunohistochemical study. (7508884)
1994
49
Treatment of stage I testis seminoma by radiotherapy: long-term results--a 30-year experience. (8365943)
1993
50
A human testicular germ cell tumor with borderline histology between seminoma and embryonal carcinoma secreted beta-human chorionic gonadotropin and alpha-fetoprotein only as a xenograft. (2423223)
1986

Genetic Variations for Seminoma

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Expression for genes affiliated with Seminoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seminoma

Search GEO for disease gene expression data for Seminoma.

Pathways for genes affiliated with Seminoma

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12EMD Millipore, 29KEGG
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Pathways related to Seminoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6TCL1A, CGB, CGB7
2
NAD metabolism
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10.6ALPI, ALPPL2, ALPP
310.6ALPI, ALPPL2, ALPP

Compounds for genes affiliated with Seminoma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Seminoma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1paraffin4411.0ALPPL2, ALPP, KIT, MAGEA1, AFP
2lactate4411.0CGB7, CGB, AFP, KIT, ALPP
3cisplatin44 49 59 1114.0ALPP, GTF2H2, AFP, CGB, CGB7
4thyroxine44 2412.0CGB7, CGB, AFP, ALPP
5oestriol4411.0AFP, CGB, CGB7
67,8-dihydroneopterin44 2411.9ALPI, ALPPL2, ALPP
7dihydroneopterin triphosphate44 2411.9ALPP, ALPPL2, ALPI
8vas-a4410.9ALPPL2, KIT, DAZL
9dihydroxyacetone44 2411.9ALPP, ALPPL2, ALPI
10methotrexate44 49 1112.9CGB7, CGB, AFP, KIT
11testosterone44 59 11 2413.9CGB7, CGB, AFP, KIT, ALPP
12butyrate4410.9AFP, ALPP, ALPPL2, ALPI
13bleomycin44 1111.8AFP, CGB, CGB7
14phosphoethanolamine4410.8ALPI, ALPP
15hydroxyurea44 49 1112.8ALPP, RAD17, KIT
16vincristine44 49 1112.7KIT, AFP, CGB
17vitamin k24410.7ALPP, AFP
18clomiphene citrate4410.6AFP, CGB
19p-nitrophenyl phosphate4410.6ALPP, ALPI
20ctp4410.5CGB, CGB7
21levamisole44 1111.3ALPPL2, ALPP

GO Terms for genes affiliated with Seminoma

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16Gene Ontology
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Cellular components related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.6ALPI, ALPPL2, ALPP

Molecular functions related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:04687210.8DNMT3L, KIT, ZNF85, ALPP, ALPPL2, ALPI
2alkaline phosphatase activityGO:00403510.3ALPI, ALPPL2, ALPP

Products for genes affiliated with Seminoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Seminoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet