Aliases & Classifications for Seminoma

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Aliases & Descriptions for Seminoma:

Name: Seminoma 8 42 10 44 61
Seminoma of Testis 61
 
Seminoma, Pure 8


Classifications:



External Ids:

Disease Ontology8 DOID:4440
NCIt39 C9309
MeSH33 D018239

Summaries for Seminoma

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Wikipedia:64 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testicle or,... more...

MalaCards based summary: Seminoma, also known as seminoma of testis, is related to testicular germ cell tumor and germ cell cancer. An important gene associated with Seminoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Selected targets of Oct 3 4 and Nicotinate and nicotinamide metabolism. The compounds oestriol and ctp have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and prostate.

Disease Ontology:8 A germinoma that has material basis in cells that make sperm and eggs.

Related Diseases for Seminoma

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Diseases related to Seminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1testicular germ cell tumor31.3KIT
2germ cell cancer31.1ALPPL2, ALPP
3dysgerminoma31.1KIT, ALPP
4cryptorchidism31.0ALPP, ALPPL2
5germinoma30.8ALPP, KIT, CGB
6gonadoblastoma30.8KIT, ALPP, ALPPL2
7embryonal cancer30.5ALPP, ALPPL2
8teratoma30.4ALPPL2, ALPP, KIT, CGB, CGB7
9sarcoma30.4CGB, KIT, MAGEA4, SSX2
10testicular cancer30.3SSX2, MAGEA4, ALPPL2, ALPP, CGB
11endodermal sinus tumor30.3CGB, ALPP, ALPPL2
12hypercalcemia30.2ALPPL2, ALPP
13choriocarcinoma29.9ALPPL2, ALPP, CGB, CGB7
14hepatitis b29.8MAGEA4, ALPPL2, ALPP, CGB
15leukemia29.4ALPPL2, ALPP, KIT, CGB
16mediastinitis10.6
17extragonadal seminoma10.5
18testis seminoma10.4
19thymic carcinoma10.4ALPP, KIT
20hypophosphatasia10.4ALPP, ALPPL2
21osteitis fibrosa10.4ALPP, ALPPL2
22hyperostosis, endosteal10.4ALPPL2, ALPP
23choledocholithiasis10.3ALPP, ALPPL2
24osteonecrosis10.3ALPPL2, ALPP
25fibrous dysplasia10.3ALPP, ALPPL2
26paget disease of bone10.3ALPPL2, ALPP
27cholelithiasis10.3ALPPL2, ALPP
28hypophosphatemic rickets, x-linked dominant10.3ALPPL2, ALPP
29sarcoma, synovial10.3KIT, SSX2
30renal osteodystrophy10.3ALPPL2, ALPP
31calcinosis10.3ALPPL2, ALPP
32hyperphosphatemia10.3ALPP, ALPPL2
33cholangitis10.3ALPP, ALPPL2
34parathyroid adenoma10.3ALPPL2, ALPP
35testicular microlithiasis10.3
36prostatitis10.3
37hypophosphatemia10.3ALPPL2, ALPP
38bilirubin metabolic disorder10.3ALPPL2, ALPP
39ectopic pregnancy10.3CGB7, CGB
40osteomalacia10.3ALPP, ALPPL2
41osteogenesis imperfecta10.3ALPPL2, ALPP
42rickets10.3ALPP, ALPPL2
43cryptococcosis10.3CGB, CGB7
44skin disease10.3ALPPL2, ALPP
45periodontal disease10.3ALPPL2, ALPP
46hyperparathyroidism10.3ALPP, ALPPL2
47leukopenia10.3ALPPL2, ALPP
48neural tube defects10.3CGB7, CGB
49sertoli cell tumor10.3
50persistent mullerian duct syndrome10.3

Graphical network of the top 20 diseases related to Seminoma:



Diseases related to seminoma

Symptoms for Seminoma

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Drugs & Therapeutics for Seminoma

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Drug clinical trials:

Search ClinicalTrials for Seminoma

Search NIH Clinical Center for Seminoma

Genetic Tests for Seminoma

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Anatomical Context for Seminoma

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MalaCards organs/tissues related to Seminoma:

31
Testis, Lymph node, Prostate, Kidney, Bone, Testes, Pineal, Brain, Spinal cord, Liver, Thyroid, T cells, Lung, Pancreas, Breast, Bone marrow, Heart, Skin, B cells, Thalamus

Animal Models for Seminoma or affiliated genes

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Publications for Seminoma

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Articles related to Seminoma:

(show top 50)    (show all 741)
idTitleAuthorsYear
1
A Risk-adapted Study of Cisplatin and Etoposide, with or Without Ifosfamide, in Patients with Metastatic Seminoma: Results of the GETUG S99 Multicenter Prospective Study. (24094847)
2014
2
Swyer Syndrome With Seminoma: Laparoscopic Bilateral Gonad Resection. (25460519)
2014
3
Seminoma stage 1: Patterns of care in Europe. (23444928)
2013
4
Unilateral seminoma in a dromedary camel. (22646829)
2013
5
Prognostic impact of LDH levels in patients with relapsed/refractory seminoma. (23640062)
2013
6
Stem cell origin of testicular seminoma. (23850550)
2013
7
Disappearance of a major thrombus in the brachiocephalic vein without anticoagulant therapy in a patient with seminoma: A case report. (23671534)
2013
8
An alternative treatment regimen of advanced seminoma with carboplatin, etoposide, and bleomycin instead of cisplatin-based therapy. (21458311)
2013
9
Utility of serum tumor markers during surveillance for stage I seminoma. (22517478)
2012
10
Late recurrence of a seminoma of the testis with a poorly differentiated neuroendocrine carcinoma component. (22084429)
2012
11
Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ERI+36 induction. (22138413)
2012
12
A large advanced seminoma in an older woman with androgen insensitivity syndrome. (22384429)
2011
13
TGF-I^1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma. (21649665)
2011
14
Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types. (21642359)
2011
15
Can radiotherapy be a viable salvage treatment option for the relapsed seminoma confined to the infra-diaphragm region recurring after primary chemotherapy for bulky stage II seminoma? (20944793)
2010
16
Increased expression of urokinase plasminogen activator and its cognate receptor in human seminomas. (20403162)
2010
17
Cytogenetic follow-up in testicular seminoma patients exposed to adjuvant radiotherapy. (20698117)
2010
18
Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas. (19023884)
2009
19
Relapse with malignant transformation after chemotherapy for primary mediastinal seminoma: case report. (19395465)
2009
20
Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: a case report. (18773441)
2008
21
The role of positron emission tomography in the evaluation of residual masses after chemotherapy for advanced stage seminoma. (18207171)
2008
22
Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. (18936476)
2008
23
Cold agglutinin disease revealing mediastinal seminoma. (17449873)
2007
24
Novel germ cell markers characterize testicular seminoma and fetal testis. (17785371)
2007
25
Complete response after treatment with imatinib in pretreated disseminated testicular seminoma with overexpression of c-KIT. (17976614)
2007
26
Evidence-based guidelines for following stage 1 seminoma. (17437287)
2007
27
Stage I seminoma. (17202824)
2006
28
Unilateral seminoma with multiple visceral metastases in a duck (Anas platyrhynchos). (16854647)
2006
29
Testicular seminoma associated with massive necrosis. (16984568)
2006
30
Long-term results of radiotherapy for early-stage testicular seminoma. (15803003)
2005
31
Long-term results of para-aortic irradiation for patients with stage I seminoma of the testis. (15708252)
2005
32
Aspiration cytology of mediastinal seminoma: report of a case with emphasis on the diagnostic role of aspiration cytology, cell block and immunocytochemistry. (16450911)
2005
33
Long-term results in patients affected by testicular seminoma treated with radiotherapy: risk of second malignancies. (15948542)
2005
34
Fertility in men after treatment for stage 1 and 2A seminoma. (15577436)
2004
35
Seminoma and a gonadoblastoma in an infant with mixed gonadal dysgenesis. (12915842)
2003
36
The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma. (12605640)
2003
37
Testicular seminoma: a clinicopathologic and immunohistochemical study of 105 cases with special reference to seminomas with atypical features. (11927966)
2002
38
Effect of hypoxia on human seminoma cells. (11956589)
2002
39
Extragonadal seminoma after renal transplantation and immunosuppression; treatment in the presence of renal dysfunction: a case report and literature review. (11917946)
2001
40
Cytokeratin expression in seminoma of the human testis. (10761461)
2000
41
Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning. (9823315)
1998
42
Placental alkaline phosphatase in patients with seminoma measured by ELISA as compared to RIA. (9491665)
1997
43
Simultaneous presentation of pineal germinoma and testicular seminoma. (8977797)
1996
44
Mesenteric desmoid tumor 19 years after radiation therapy for testicular seminoma. (7974887)
1994
45
Testicular microlithiasis and seminoma. (8280236)
1993
46
Immunopathology of alkaline phosphatase isozymes in seminoma. (8434423)
1993
47
Placental-like alkaline phosphatase and DNA flow cytometry in spermatocytic seminoma. (1310437)
1992
48
Seminoma of the testis in a patient with 48,XXYY variant of Klinefelter's syndrome. (2052972)
1991
49
Fine-needle aspiration biopsy of seminoma and dysgerminoma: cytologic, histologic, and electron microscopic correlations. (2159868)
1990
50
Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene. (2834730)
1988

Variations for Seminoma

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Expression for genes affiliated with Seminoma

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Search GEO for disease gene expression data for Seminoma.

Pathways for genes affiliated with Seminoma

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Pathways related to Seminoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde36
NAD salvage36
NAD metabolism59
8.8ALPI, ALPP, ALPPL2
28.8ALPI, ALPP, ALPPL2

Compounds for genes affiliated with Seminoma

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Compounds related to Seminoma according to GeneCards Suite gene sharing:

(show all 30)
idCompoundScoreTop Affiliating Genes
1oestriol4410.1CGB, CGB7
2ctp4410.1CGB, CGB7
3vas-a449.9DAZL, ALPPL2, KIT
4levamisole44 1110.9ALPPL2, ALPP
5methotrexate50 44 1111.8KIT, CGB, CGB7
6thyroxine44 2410.6ALPP, CGB7, CGB
7Isopropyl alcohol249.6ALPPL2, ALPI
81-Pentanol249.5ALPI, ALPPL2
91-Hexanol249.5ALPI, ALPPL2
10Isobutanol249.5ALPI, ALPPL2
11Propyl alcohol249.5ALPI, ALPPL2
12phosphoethanolamine449.5ALPI, ALPP
131-Butanol249.5ALPI, ALPPL2
14p-nitrophenyl phosphate449.5ALPP, ALPI
15paraffin449.3KIT, ALPP, ALPPL2
16lactate449.3KIT, CGB, CGB7, ALPP
17cellulose acetate449.3ALPP, ALPI
18testosterone44 60 24 1112.3ALPP, CGB, KIT, CGB7
197,8-dihydroneopterin44 2410.2ALPI, ALPP, ALPPL2
20dihydroneopterin triphosphate44 2410.1ALPPL2, ALPP, ALPI
21dihydroxyacetone44 2410.1ALPPL2, ALPP, ALPI
224-Nitrophenol249.1ALPP, ALPPL2, ALPI
23hydroxyapatite449.1ALPP, ALPI
24Dihydroxyacetone phosphate249.1ALPP, ALPI, ALPPL2
25cisplatin44 50 60 1112.1CGB7, CGB, GTF2H2, ALPP
26cysteine448.9CGB7, KIT, CGB, ALPP
27butyrate448.9ALPI, ALPPL2, ALPP
28guanidine hydrochloride448.8ALPI, ALPP
29Phosphate248.8ALPI, ALPP, ALPPL2
30zinc44 249.6GTF2H2, ALPI, SSX2, DNMT3L

GO Terms for genes affiliated with Seminoma

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Cellular components related to Seminoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:00312258.8ALPI, ALPP, ALPPL2

Biological processes related to Seminoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:00072839.6KIT, DNMT3L, DAZL
2dephosphorylationGO:00163118.5ALPI, ALPP, ALPPL2

Molecular functions related to Seminoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00040358.8ALPI, ALPP, ALPPL2

Sources for Seminoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet