MCID: SMN007
MIFTS: 42

Seminoma malady

Summaries for Seminoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testis or, more... more...

MalaCards: Seminoma, also known as seminoma, pure, is related to testicular cancer and germ cell tumors. An important gene associated with Seminoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Selected targets of Oct-3/4 and NAD metabolism. The compounds paraffin and lactate have been mentioned in the context of this disorder.

Description from OMIM:47 273300

Aliases & Classifications for Seminoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 47OMIM
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Aliases & Descriptions:

seminoma 8 43 10 45 61
seminoma, pure 8


External Ids:

Disease Ontology8 DOID:4440
MeSH35 D018239
NCIt40 C9309
OMIM47 273300

Related Diseases for Seminoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Seminoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1testicular cancer30.7AFP, ALPP
2germ cell tumors30.7KIT
3germ cell cancer30.5AFP, ALPP, ALPPL2
4germinoma30.5CGB, AFP, KIT, ALPP
5dysgerminoma30.5ALPP, KIT, AFP
6teratoma30.4CGB7, CGB, AFP, KIT, ALPP, ALPPL2
7gonadoblastoma30.4KIT, ALPP, ALPPL2
8sertoli cell tumor30.4ALPP
9male germ cell tumor, somatic30.1DNMT3L, SLC2A6
10extragonadal germ cell tumor30.1AFP
11squamous cell carcinoma30.0ALPP, MAGEA4, MAGEA1, CGB, CGB7
12adenocarcinoma29.8CGB7, CGB, AFP, MAGEA1, MAGEA4
13hypercalcemia29.8ALPP, ALPPL2
14testis seminoma10.8
15extragonadal seminoma10.6
16testicular germ cell tumor10.4
17mediastinum seminoma10.3
18testicular microlithiasis10.3
19androgen insensitivity syndrome10.2
20testicular spermatocytic seminoma10.2
21spermatocytoma10.2
22klinefelter's syndrome10.2
23cryptorchidism10.2
24intratubular embryonal carcinoma10.2
25exophthalmos10.1
26orchitis10.1
27tubular variant testicular seminoma10.1
28pseudoglandular variant testicular seminoma10.1
29malignant sertoli cell tumor10.1
30persistent mullerian duct syndrome10.1
31superior vena cava syndrome10.1
32spermatocytic seminoma, somatic10.1
33malignant peritoneal mesothelioma10.0
34cribriform variant testicular seminoma10.0
35renal agenesis10.0
36hydronephrosis10.0
37testicular gonadoblastoma10.0
38gynecomastia10.0
39mixed gonadal dysgenesis10.0
40pheochromocytoma10.0
41nonseminomatous germ cell tumor10.0
42breast cancer10.0CGB7, CGB, SSX2, MAGEA1, MAGEA4, KIT
43myeloma10.0MAGEA1, TCL1A, ALPP, ALPPL2
44cholangiocarcinoma10.0ALPPL2, ALPP, AFP, CGB
45choriocarcinoma10.0ALPPL2, ALPP, AFP, CGB, CGB7
46ovarian cancer10.0CGB, AFP, SSX2, MAGEA1
47hepatitis b10.0ALPPL2, ALPP, MAGEA4, MAGEA1, AFP, CGB
48leukemia10.0ALPPL2, ALPP, TCL1A, KIT, MAGEA1, CGB
49sarcoma10.0CGB, SSX2, MAGEA1, MAGEA4, KIT
50embryonal cancer10.0ALPPL2, ALPP, AFP

Graphical network of the top 20 diseases related to Seminoma:



Diseases related to seminoma

Clinical Features for Seminoma

Sources:
47OMIM
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Clinical features from OMIM:

273300

Drugs & Therapeutics for Seminoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Seminoma

Drug clinical trials:

Search ClinicalTrials for Seminoma

Search NIH Clinical Center for Seminoma

Search CenterWatch for Seminoma

Genetic Tests for Seminoma

Anatomical Context for Seminoma

Animal Models for Seminoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Seminoma

Sources:
51PubMed
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Articles related to Seminoma:

(show top 50)    (show all 772)
idTitleAuthorsYear
1
Seminoma stage 1: Patterns of care in Europe. (23444928)
2013
2
Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept. (23784825)
2013
3
Carboplatin AUC 10 for IGCCCG good prognosis metastatic seminoma. (22943385)
2013
4
Contemporary management of stage I and II seminoma. (23949632)
2013
5
Mediastinal seminoma: a case report with special emphasis on SALL4 as a new immunocytochemical marker. (22298374)
2013
6
Testicular seminoma and non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (24078656)
2013
7
Single inguinal node metastasis of stage I testicular seminoma shown by scrotal scintigraphy, 6 months following radical orchiectomy. (22741151)
2012
8
Unilateral testicular seminoma with simultaneous contralateral torsion: a case report. (22800561)
2012
9
Incidence of second malignancies after external beam radiotherapy for clinical stage I testicular seminoma. (21883828)
2012
10
Giant testicular seminoma. (22901819)
2012
11
Successful treatment of mediastinal seminoma in a hemodialysis patient. (22868508)
2012
12
Spermatocytic seminoma: toward further understanding of pathogenesis. (21725972)
2011
13
Genome-wide analysis of genetic alterations in testicular primary seminoma using high resolution single nucleotide polymorphism arrays. (21376111)
2011
14
Chest radiography not needed in seminoma surveillance. (20397285)
2010
15
Inguinal lymph node metastases from a testicular seminoma: a case report and a review of the literature. (21108777)
2010
16
Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: serum protein profiling in seminoma patients. (19529944)
2010
17
Identification of nuclear structural protein alterations associated with seminomas. (19795381)
2009
18
Cisplatin-based chemotherapy for advanced seminoma: report of 52 cases treated in two institutions. (19437039)
2009
19
Chemotherapy as an alternative to radiotherapy in the treatment of stage IIA and IIB testicular seminoma: a Spanish Germ Cell Cancer Group Study. (18936476)
2008
20
Seminoma of testis masquerading as orchitis in an adult with paraplegia: proposed measures to avoid delay in diagnosing testicular tumours in spinal cord injury patients. (18264632)
2008
21
Apoptosis in spermatocytic and usual seminomas: a light microscopic and immunohistochemical study. (17643097)
2007
22
Occult lumbar vertebral body metastasis of non-seminomatous germ cell tumor eradicated by radiation and salvage surgery 9 years after initial onset]. (17564107)
2007
23
Two cycles of etoposide/cisplatin cured all patients with stage I testicular seminoma: risk-adapted protocol of the Hellenic Cooperative Oncology Group. (18158042)
2007
24
Case of seminoma with possible spontaneous regression without extragonadal metastatic lesion. (18158054)
2007
25
Malignant spinal cord compression secondary to testicular seminoma at the time of initial presentation and at relapse while on surveillance. (18542765)
2007
26
Treatment options, prognostic factors and selection of treatment in stage I seminoma. (17202831)
2006
27
Data required for testicular dose calculation during radiotherapy of seminoma. (16898441)
2006
28
Cyclophosphamide-induced cardiomyopathy in a patient with seminoma and a history of mediastinal irradiation. (15750271)
2005
29
Towards individualised radiotherapy for Stage I seminoma. (16169622)
2005
30
Risk-adapted management for patients with clinical stage I seminoma: the Second Spanish Germ Cell Cancer Cooperative Group study. (16260698)
2005
31
Testicular cancer: seminoma. (16620449)
2005
32
Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial. (16039331)
2005
33
Fertility in men after treatment for stage 1 and 2A seminoma. (15577436)
2004
34
Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors. (15361850)
2004
35
Late relapse of stage I testicular seminoma metastatic to just a para-ureteropelvic region. (15509217)
2004
36
Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report. (15546481)
2004
37
Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. (11979085)
2002
38
Advanced non-seminomatous germ cell cancer of the testis with brain metastases: feasibility of additional brain irradiation and whole body hyperthermia plus chemotherapy. (11182030)
2001
39
Surveillance programs for early stage non-seminomatous testicular cancer: a practice guideline. (11268306)
2001
40
Suppression of spermatogenesis in ipsilateral and contralateral testicular tissues in patients with seminoma by human chorionic gonadotropin beta subunit. (11489712)
2001
41
Scleromyxedema: possible association with seminoma. (10767692)
2000
42
Persistent mA1llerian duct syndrome with torsion of an intra-abdominal seminoma. (10582079)
1999
43
Specific determination of germ cell alkaline phosphatase for early diagnosis and monitoring of seminoma: performance and limitations of different analytical techniques. (9657344)
1998
44
Pitfalls of hCG monitoring in stage I seminoma. (9610904)
1998
45
Placental alkaline phosphatase in patients with seminoma measured by ELISA as compared to RIA. (9491665)
1997
46
Testicular seminoma in a patient with pineal germinoma. (7962639)
1994
47
Immunohistochemical comparison between anaplastic seminoma and typical seminoma. (7509106)
1993
48
Single agent activity of carboplatin in patients with previously untreated non-seminomatous germ cell tumours. (1376619)
1992
49
Polycythemia and steroid overproduction in a gonadotropin-secreting seminoma of the testis. (1913460)
1991
50
Endodermal sinus tumor (yolk sac tumor), seminoma and hemangiopericytoma. Rare primary mediastinal tumors. A report on the course of the disease in nine patients. (6158129)
1980

Genetic Variations for Seminoma

Expression for genes affiliated with Seminoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Seminoma

Search GEO for disease gene expression data for Seminoma.

Pathways for genes affiliated with Seminoma

Sources:
12EMD Millipore, 30KEGG
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Pathways related to Seminoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6TCL1A, CGB, CGB7
2
NAD metabolism
Hide members
10.6ALPI, ALPPL2, ALPP
310.6ALPI, ALPPL2, ALPP

Compounds for genes affiliated with Seminoma

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Seminoma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1paraffin4511.0ALPPL2, ALPP, KIT, MAGEA1, AFP
2lactate4511.0CGB7, CGB, AFP, KIT, ALPP
3cisplatin45 50 60 1114.0ALPP, GTF2H2, AFP, CGB, CGB7
4thyroxine45 2412.0CGB7, CGB, AFP, ALPP
5oestriol4511.0AFP, CGB, CGB7
67,8-dihydroneopterin45 2411.9ALPI, ALPPL2, ALPP
7dihydroneopterin triphosphate45 2411.9ALPP, ALPPL2, ALPI
8vas-a4510.9ALPPL2, KIT, DAZL
9dihydroxyacetone45 2411.9ALPP, ALPPL2, ALPI
10methotrexate45 50 1112.9CGB7, CGB, AFP, KIT
11testosterone45 60 11 2413.9CGB7, CGB, AFP, KIT, ALPP
12butyrate4510.9AFP, ALPP, ALPPL2, ALPI
13bleomycin45 1111.8AFP, CGB, CGB7
14phosphoethanolamine4510.8ALPI, ALPP
15hydroxyurea45 50 1112.8ALPP, RAD17, KIT
16vincristine45 50 1112.7KIT, AFP, CGB
17vitamin k24510.7ALPP, AFP
18clomiphene citrate4510.6AFP, CGB
19p-nitrophenyl phosphate4510.6ALPP, ALPI
20ctp4510.5CGB, CGB7
21levamisole45 1111.3ALPPL2, ALPP

GO Terms for genes affiliated with Seminoma

Sources:
16Gene Ontology
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Cellular components related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.6ALPI, ALPPL2, ALPP

Molecular functions related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:04687210.8DNMT3L, KIT, ZNF85, ALPP, ALPPL2, ALPI
2alkaline phosphatase activityGO:00403510.3ALPI, ALPPL2, ALPP

Products for genes affiliated with Seminoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Seminoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet