Seminoma malady

Wikipedia: Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testis or, more...⁴⁴ more...

MalaCards: Seminoma, also known as seminoma, pure, is related to testis seminoma and extragonadal seminoma. An important gene associated with Seminoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Akt Signaling and Actin-Based Motility by Rho Family GTPases. The compounds egcg and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and breast, and related mouse phenotypes are craniofacial and respiratory system.

Aliases & Descriptions:

seminoma 6 30 8 32 43 seminoma, pure 6

Diseases related to seminoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 705)

id	Related Disease	Score	Top Affiliating Genes
1	testis seminoma	33.7	RAD17P1, RAD17, RAD17P2, GTF2H2, ZNF85, SLC2A6
2	extragonadal seminoma	30.9	LRRC4C, KIT, GPR98
3	dysgerminoma	30.3	KIT, KITLG, CGA, CGB, CGB5, ITGAL
4	nonseminomatous germ cell tumor	29.1	CGA, CGB, CGB5, CGB7, AFP
5	malignant sertoli cell tumor	28.9	CGB5, ALPP, AFP
6	endodermal sinus tumor	28.8	CGA, ALPP, ACPP, AFP
7	gonadoblastoma	28.8	KIT, RB1, NANOG, CGB, ALPP, ALPPL2
8	sertoli cell tumor	28.7	KIT, SELE, VIM, VCAM1, CGB, CGB5
9	mediastinitis	28.6	KIT, SELE, VIM, VEGFC, MYC, CHKB
10	male germ cell tumor	28.0	KIT, RASSF1, ZFP42, CGB5, CDK2, MGMT
11	germinoma	27.9	KIT, KITLG, BCL2, BAX, CGA, CGB
12	dna topoisomerase ii	27.2	MYC, CDK2, GSTP1, TP53, TOP1, TOP2A
13	germ cell tumor	27.1	KIT, KITLG, RB1, NANOG, BRAF, RARB
14	testicular germ cell tumor	26.6	KIT, RB1, BRAF, RARB, BAX, CGA
15	teratoma	26.6	KLF4, RET, KIT, VIM, NANOG, BCL2
16	polycythemia	26.1	KIT, KITLG, RARB, FASLG, FAS, IDH1
17	sinusitis	23.7	VIM, VCAM1, MYC, BAX, CGA, CGB7
18	lung carcinoma	23.0	RB1, SERPINB2, BRAF, VEGFC, MYC, RAD17
19	retinoblastoma	19.8	KIT, KITLG, RB1, SERPINB2, VIM, VEGFC
20	carcinoma	18.3	ZNF354A, KLF4, REG1A, RET, KIT, KITLG
21	breast carcinoma	18.0	KIT, KITLG, RB1, SELE, SERPINB2, VIM
22	prostatitis	17.4	KLF4, RET, KIT, KITLG, RB1, SELE
23	hypoxia	17.3	ZNF354A, RET, KIT, KITLG, RB1, SELE
24	neuronitis	14.8	LRRC4C, KLF4, REG1A, RET, KIT, KITLG
25	testicular neoplasm	14.3	KIT, LNPEP, INHA, ALPL, ALPP, ALPPL2
26	neural tube defect	14.2	CGA, CGB, CGB5, CGB7, PDGFRA, AFP
27	epithelioid trophoblastic tumor	14.2	LNPEP, CGA, CGB5, INHA, ALPP
28	gestational trophoblastic tumor	14.2	CGA, CGB, CGB5, ERVK-6, H19
29	extragonadal germ cell tumor	14.2	CGB, CGB5, GPC3, SLPI, AFP
30	gestational trophoblastic neoplasm	14.2	CGA, CGB5, INHA, NLRP7, STARD7, AFP
31	trophoblastic neoplasm	14.2	LNPEP, LGALS1, CGA, CGB5, INHA
32	mature teratoma	14.2	CGA, CGB, ALPP, AFP
33	ovarian cancer	14.2	INHA, ALPP, CALB2, KRAS, NME1
34	pediatric cns embryonal cell carcinoma	14.1	KIT, KITLG, RARB, CGA, CGB, CGB5
35	hypophosphatasia	14.1	ALPI, ALPL, ALPP, ALPPL2, SLPI
36	androgen insensitivity syndrome	14.1	LNPEP, CGA, INHA, IGF2, IGFBP2, ALPPL2
37	central nervous system germinoma	14.1	CGB, ALPP, POU5F1
38	ectopic pregnancy	14.1	CHKB, CGA, CGB, CGB5, CGB7
39	placental insufficiency	14.1	LNPEP, LGALS1, CGA, CALB2, AFP
40	central nervous system germ cell tumor	14.1	CGB, PDPN, AFP
41	common bile duct disease	14.0	ALPL, ALPP, ALPPL2
42	sycp3-related pregnancy loss, susceptibility to	14.0	CGA, CGB, CGB5, CGB7, GNRH1
43	carney triad	14.0	KIT, PDGFRA, PDPN, DES
44	sacrococcygeal teratoma	14.0	RET, NANOG, CGA, CGB7, POU5F1, AFP
45	lymphedema, congenital	14.0	VEGFC, FLT4, PDPN
46	peripheral t-cell lymphoma	14.0	TNFRSF8, PTPRC, PDGFRA, TCL1A, NME1
47	osteosclerosis	14.0	IGF2, IGFBP2, ALPL, ALPP, ALPPL2
48	thyrotoxicosis	14.0	CGA, CGB7, ALPP, GNRH1, SLPI
49	acinar cell carcinoma	14.0	REG1A, APC, IGF2, SMAD4, AFP
50	kidney clear cell sarcoma	14.0	KIT, BRAF, IGF2, CREB1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to seminoma:

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MGI Mouse Phenotypes related to seminoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.1	KLF4, KIT, KITLG, RAD17, XPA, MMP16
2	respiratory system phenotype	MP:0005388	10.0	RET, MEG3, ALPL, PTPRC, SOX5
3	endocrine/exocrine gland phenotype	MP:0005379	10.0	KLF4, REG1A, RET, NANOS3, ZFP42, LDHC
4	liver/biliary system phenotype	MP:0005370	9.8	KIT, RAD17, MEG3, CCND2, ESR2, TP53
5	other phenotype	MP:0005395	9.7	RARB, ITGB1, ALPL, GJA1, ESR2, PDGFRA
6	embryogenesis phenotype	MP:0005380	9.4	RET, KIT, VIM, NANOG, NASP, BRAF
7	hematopoietic system phenotype	MP:0005397	9.1	KIT, SERPINB2, BRAF, BCL2, XPA, CDKN2C
8	immune system phenotype	MP:0005387	8.9	KIT, SERPINB2, VIM, BRAF, LGALS1, XPA
9	reproductive system phenotype	MP:0005389	8.4	KLF4, REG1A, RET, NANOS3, RARB, ZFP42
10	pigmentation phenotype	MP:0001186	8.3	KIT, KITLG, RB1, BRAF, MYC, BCL2
11	limbs/digits/tail phenotype	MP:0005371	8.1	RET, KIT, KITLG, RB1, RARB, CHKB
12	behavior/neurological phenotype	MP:0005386	8.1	KLF4, KIT, RB1, SELE, VIM, BRAF
13	no phenotypic analysis	MP:0003012	7.9	RET, RB1, NANOG, NANOS3, VCAM1, LNPEP
14	renal/urinary system phenotype	MP:0005367	7.6	RET, KIT, BRAF, RARB, BCL2, BAX
15	hearing/vestibular/ear phenotype	MP:0005377	7.6	KIT, KITLG, RB1, MYC, RARB, BCL2
16	normal phenotype	MP:0002873	7.6	KLF4, RET, SELE, BRAF, MYC, RARB
17	integument phenotype	MP:0010771	7.6	KLF4, KIT, KITLG, RB1, BRAF, MYC
18	mortality/aging	MP:0010768	7.4	KLF4, RET, KITLG, RB1, SELE, SERPINB2
19	digestive/alimentary phenotype	MP:0005381	6.9	KLF4, RET, KIT, KITLG, RB1, BRAF
20	adipose tissue phenotype	MP:0005375	6.8	RB1, BRAF, MYC, BCL2, XPA, FLT4
21	nervous system phenotype	MP:0003631	6.7	KIT, KITLG, RB1, BRAF, MYC, RAD17
22	skeleton phenotype	MP:0005390	6.5	KIT, KITLG, RB1, BRAF, MYC, RARB
23	vision/eye phenotype	MP:0005391	5.5	KIT, KITLG, RB1, SELE, VIM, BRAF
24	tumorigenesis	MP:0002006	5.2	KLF4, RET, KIT, KITLG, RB1, BRAF
25	muscle phenotype	MP:0005369	4.8	RET, KIT, RB1, SERPINB2, VIM, BRAF
26	cardiovascular system phenotype	MP:0005385	4.3	RET, KIT, KITLG, RB1, SELE, VIM
27	growth/size phenotype	MP:0005378	4.1	RET, KIT, KITLG, RB1, SELE, SERPINB2
28	cellular phenotype	MP:0005384	3.4	KLF4, RET, KIT, KITLG, RB1, SELE
29	homeostasis/metabolism phenotype	MP:0005376	3.2	KLF4, REG1A, RET, KIT, KITLG, RB1

Articles related to seminoma:

(show top 50)    (show all 145)

id	Title	Authors	Year	Affiliating Genes
1	MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors. (21780320)	Bode P.K.... Moch H.	2011	MAGEC2
2	Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma. (19226408)	Bouskine A.... FAcnichel P.	2010	KIT
3	Podoplanin, a novel marker for seminoma: A comparison study evaluating immunohistochemical expression of podoplanin and OCT3/4. (20850695)	Idrees M.... Badve S.	2010	PDPN
4	Identification of nuclear structural protein alterati ons associated with seminomas. (19795381)	Leman E.S.... Getzenberg R.H.	2009	NUMA1, CDK10, STARD7
5	Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas. (19023884)	Barbagallo F.... Sette C.	2009	NEK2
6	Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. (19255517)	Yu C.H.... Sur J.H.	2009	KIT, VIM, DES
7	Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrog en receptor. (19654912)	Bouskine A.... Fenichel P.	2009	ESR1, CREB1
8	Further characterization of the first seminoma cell line TCam-2. (18050305)	de Jong J.... Looijenga L.H.	2008	KIT, KITLG, ALPP
9	Place of serum HCG assay in the follow-up of non-HCG-secreting testicular seminomas (18971108)	Djeffal C.... Petit J.	2008	CGA
10	Complete response after imatinib mesylate administrat ion in a patient with chemoresistant stage IV seminoma. (18751412)	Pectasides D.... Economopoulos T.	2008	CSF3, CGB7
11	Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors. (18622385)	Netto G.J.... De Marzo A.M.	2008	DMAP1
12	Novel germ cell markers characterize testicular seminoma and fetal testis. (17785371)	Gashaw I.... Winterhager E.	2007	MCFD2, PROM1, POU2AF1
13	Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms. (17951198)	Yu H.... Hornick J.L.	2007	PDPN
14	Histologically pure stage I seminoma with an elevated beta-hCG of 4497 IU/l. (18068467)	Bjurlin M.A.... Totonchi E.	2007	CGB5
15	Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in Sertoli cells and germ cells. (16820096)	Brehm R.... Bergmann M.	2006	GJA1
16	Estrogen-induced growth inhibition of human seminoma cells expressing estrogen receptor beta and aromatase. (16087732)	Roger C.... Fenichel P.	2005	ESR2
17	Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4. (16158187)	Gashaw I.... Winterhager E.	2005	ETV4, NASP
18	Identification of two molecular groups of seminomas by using expression and tissue microarrays. (16115909)	Hofer M.D.... Rubin M.A.	2005	ALPPL2, SLC43A1
19	Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. (15316315)	Henley J.D.... Ulbright T.M.	2004	KIT, ALPPL2
20	Gene expression profiling identifies a set of transcripts that are up-regulated inhuman testicular seminoma. (15747581)	Yamada S.... Arai Y.	2004	CCND2
21	The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma. (12605640)	Rajpert-De Meyts E.... Skakkebaek N.E.	2003	ALPPL2, MAGEA4
22	Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. (14612934)	Okada K.... Nakamura Y.	2003	CCND2, JUP, SLC43A1
23	Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma. (12210085)	Brehm R.... Steger K.	2002	GJA1, GJB2
24	Bax, Bcl-2, fas and Fas-L antigen expression in human seminoma: correlation with the apoptotic index. (12583439)	Grobholz R.... Bleyl U.	2002	BCL2, BAX, FAS
25	Testicular seminoma: a clinicopathologic and immunohistochemical study of 105 cases with special reference to seminomas with atypical features. (11927966)	Tickoo S.K.... Reuter V.E.	2002	KIT
26	Effect of hypoxia on human seminoma cells. (11956589)	Fujii T.... Tanaka H.	2002	HIF1A
27	The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. (12065688)	Satie A.P.... Samson M.	2002	CTAG1A, CTAG1B
28	Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. (11979085)	Henley J.D.... Ulbright T.M.	2002	ALPP
29	Cytokeratin expression in seminoma of the human testis. (10761461)	Cheville J.C.... Pankratz V.S.	2000	CHKB
30	A novel SMAD4 gene mutation in seminoma germ cell tumors. (10706106)	Bouras M.... Benahmed M.	2000	SMAD4
31	Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma. (11173850)	Lau Y.-F.C.... Koemueves L.G.	2000	TSPY1
32	Tubular seminoma of the testis. (10504533)	Takeshima Y.... Inai K.	1999	ALPP
33	Prognostic factors in seminomas with special respect to HCG: results of a prospective multicenter study. Seminoma Study Group. (10559615)	Weissbach L.... Fassbinder J.	1999	CGA
34	Pitfalls of hCG monitoring in stage I seminoma. (9610904)	Wylie J.P.... Logue J.P.	1998	CGA
35	Immunohistochemical analysis of the nm23 gene products in testicular seminoma. (9143023)	Hori K.... Ohya M.	1997	NME1
36	The value of tumor markers in testicular seminomas. R esults of a prospective multicenter study. (9266226)	Weissbach L.... Mann K.	1997	ALPP, CGA
37	Placental alkaline phosphatase in patients with seminoma measured by ELISA as compared to RIA. (9491665)	Redkar S.L.... Damle S.R.	1997	ALPP
38	Elevated human chorionic gonadotropin concentrations in the testicular vein and in peripheral venous blood in seminoma patients. An analysis of various parameters. (9187899)	Hartmann M.... Weissbach L.	1997	CGA
39	Anaplastic variant of spermatocytic seminoma. (8698307)	Albores-Saavedra J.... Ayala A.G.	1996	PTPRC
40	A potential use of a monoclonal antibody to placental alkaline phosphatase (PLAP) to detect lymph node metastases of seminoma. (7490882)	Koshida K.... Hirano K.	1996	ALPP
41	Heterogeneity in the in vitro survival and proliferation of human seminoma cells. (7529524)	Olie R.A.... Oosterhuis J.W.	1995	FGF2, KITLG
42	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas. (7983737)	Sauter M.... Mueller-Lantzsch N.	1995	ERVK-6, ERVK-5, ERVK-10
43	The tumor microenvironment: possible role of integrins and the extracellular matrix in tumor biological behavior of intratubular germ cell neoplasia and testicular seminomas. (8178927)	Timmer A.... Timens W.	1994	ITGB1, ITGA3
44	Tubular seminoma. An immunohistochemical and DNA flow-cytometric study of four cases. (7524297)	Zavala-Pompa A.... Ayala A.G.	1994	ALPP
45	Immunohistochemical comparison between anaplastic seminoma and typical seminoma. (7509106)	Suzuki T.... Aizawa S.	1993	ALPP, AFP, CGB
46	Is placental alkaline phosphatase (PLAP) a useful marker for seminoma? (2148879)	Nielsen O.S.... Thomas G.M.	1990	ALPP
47	Heterogeneity of intermediate filament expression in human testicular seminomas. (1708736)	Fogel M.... Czernobilsky B.	1990	KRT4
48	Enolase isozymes in seminoma. (2204171)	Takashi M.... Kato K.	1990	ENO2
49	Isoenzymes of alkaline phosphatases in seminomas. An immunohistochemical and biochemical study. (2248772)	Brehmer-Andersson E.... Wahren B.	1990	ALPP, ACP2
50	Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene. (2834730)	Millan J.L.... Manes T.	1988	ALPPL2

Genes related to seminoma according to GeneCards:

(show top 50)    (show all 159)

id	Symbol	Description	Score	GeneCards Section Context
1	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
2	RAD17P1	RAD17 homolog (S. pombe) pseudogene 1	11.0	Publications
3	RAD17P2	RAD17 homolog (S. pombe) pseudogene 2	11.0	Publications
4	ALPPL2	alkaline phosphatase, placental-like 2	11.0	Publications
5	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
6	SLC43A1	solute carrier family 43, member 1	11.0	UniProt Related, Publications
7	GTF2H2	general transcription factor IIH, polypeptide 2, 44kDa	11.0	Publications
8	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
9	ZNF85	zinc finger protein 85	11.0	Functions, Publications
10	ALPP	alkaline phosphatase, placental	11.0	Publications
11	TCL1A	T-cell leukemia/lymphoma 1A	11.0	Publications
12	RAD17	RAD17 homolog (S. pombe)	11.0	Functions, Publications, Expressions
13	SSX2	synovial sarcoma, X breakpoint 2	11.0	Publications
14	SLC2A6	solute carrier family 2 (facilitated glucose transporter), member 6	11.0
15	ALPI	alkaline phosphatase, intestinal	11.0	Publications
16	DAZL	deleted in azoospermia-like	11.0	Publications
17	MAGEA4	melanoma antigen family A, 4	11.0	Publications
18	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0	Publications
19	FGF4	fibroblast growth factor 4	11.0
20	INHA	inhibin, alpha	11.0	Publications
21	CCND2	cyclin D2	11.0	Publications
22	NLRP7	NLR family, pyrin domain containing 7	11.0	Publications
23	PDPN	podoplanin	11.0	Publications
24	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
25	POU5F1	POU class 5 homeobox 1	11.0	Publications
26	AFP	alpha-fetoprotein	11.0	Publications
27	ERVK-6	endogenous retrovirus group K, member 6	11.0	Publications
28	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	11.0
29	MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	11.0
30	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
31	JUP	junction plakoglobin	11.0	Publications
32	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
33	TOP2A	topoisomerase (DNA) II alpha 170kDa	11.0	Publications
34	ERVW-1	endogenous retrovirus group W, member 1	11.0
35	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
36	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
37	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0	Publications
38	TERC	telomerase RNA component	11.0
39	LNPEP	leucyl/cystinyl aminopeptidase	11.0
40	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
41	FLT4	fms-related tyrosine kinase 4	11.0
42	MVP	major vault protein	11.0
43	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	11.0
44	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications
45	KRT18	keratin 18	11.0
46	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
47	SMAD4	SMAD family member 4	11.0	Publications
48	MMP16	matrix metallopeptidase 16 (membrane-inserted)	11.0	Publications
49	GPC3	glypican 3	11.0
50	CCNA2	cyclin A2	11.0

Pathways related to seminoma according to GeneDecks:

(show top 50)    (show all 118)

id	Pathway	Score	Top Affiliating Genes
1	Akt Signaling36	10.9	FLT4, PDGFRA, KIT, TNFRSF8, CCND2, FGF4
2	Actin-Based Motility by Rho Family GTPases36	10.8	ITGAL, FGF4
3	Selected targets of Oct-3/410	10.5	PDGFRA, SMAD4, TP53, GJA1, FGF4, CGB7
4	Breast Cancer Regulation by Stathmin136	10.5	FGF4, FGF2
5	Human Embryonic Stem Cell Pluripotency36	10.5	TEAD4, PDGFRA, SOX2, POU5F1, ZNF354A, APC
6	Colorectal cancer20	10.4	TGFB1, BRAF
7	PPAR Pathway36	10.3	FGF2, KIT, FGF4, ITGAL, ITGA3, ITGB1
8	Development Role of Activin A in cell differentiation and proliferation10	10.3	SMAD4, INHBA, CGA, MYC, NANOG, CREB1
9	Ras Pathway36	10.3	GNRH1, FGF4, FGF2, FLT4, IGF2, ITGB1
10	Development_Role of Activin A in cell differentiation and proliferation41	10.3	POU5F1, SMAD4, INHBA, CGA, MYC, NANOG
11	eIF2 Pathway36	10.2	FGF2, PDGFRA, GNRH1, IGF2, FGF4, KIT
12	Paxillin Interactions36	10.1	ITGB1, ITGA3, VEGFC, KITLG, KIT, FGF2
13	PTEN Pathway36	9.9	FGF4, FGF2, TP53, PDGFRA, GNRH1, FLT4
14	Nanog in Mammalian ESC Pluripotency36	9.9	GNRH1, FGF2, VEGFC, KITLG, BRAF, NANOG
15	ERK5 Signaling36	9.9	CREB1, PDGFRA, TGFB1, KITLG, FGF4, KIT
16	Glioblastoma Multiforme36	9.8	MGMT, IGF2, CDK2, RB1, APC, PDGFRA
17	Bladder cancer20	9.8	TP53, RB1, MYC, VEGFC, DAPK1, RASSF1
18	Glioma Invasiveness36	9.8	GNRH1, FGF2, ITGB1, ITGAL, FGF4, VEGFC
19	ILK Signaling36	9.8	CREB1, KRT18, HIF1A, TEAD4, ZNF354A, KIT
20	Cell Cycle / Checkpoint Control3	9.8	RAD17, TP53, CDK2, MGMT, GSTP1, CCNA2
21	Nuclear Receptor Activation by Vitamin-A36	9.8	FGF4, CREB1, PDGFRA, RARB, FGF2, GTF2H2
22	Telomerase Components in Cell Signaling36	9.7	PDGFRA, KIT, KITLG, RB1, VEGFC, FLT4
23	G1-S Phase Transition36	9.7	TP53, CCND2, CDK2, CDKN2C, TGFB1, CCNA2
24	Rac1 Pathway36	9.6	ITGA3, ITGAL, ITGB1, FLT4, KITLG, FGF2
25	Apoptotic Pathways in Synovial Fibroblasts36	9.6	TGFB1, VEGFC, KIT, KITLG, FLT4, FGF2
26	HIF1Alpha Pathway36	9.4	UBC, TP53, HIF1A, VEGFC, CREB1, SLC2A6
27	Rap1 Pathway36	9.3	FGF2, BRAF, VEGFC, ITGA3, ITGB1, FGF4
28	eNOS Signaling36	9.3	KIT, KITLG, FLT4, VEGFC, GNRH1, FGF2
29	Renin-Angiotensin Pathway36	9.3	KITLG, GNRH1, PDGFRA, KIT, VCAM1, FLT4
30	Prostate cancer20	9.3	PDGFRA, KRAS, TP53, RB1, BRAF, BCL2
31	DHA Signaling36	9.2	IGF2, KITLG, VEGFC, BCL2, BAX, FLT4
32	Cell cycle20	9.1	RB1, MYC, CDKN2C, CDK2, CCNA2, TP53
33	GPCR Pathway36	9.0	KIT, STAT3, KITLG, BRAF, VEGFC, FGF4
34	Selected targets of p5310	8.9	MGMT, APC, DAPK1, TP53, CDK2, BAX
35	Estrogen Pathway36	8.8	VEGFC, BCL2, TGFB1, PDGFRA, ESR2, GNRH1
36	p53 Mediated Apoptosis36	8.8	KIT, KITLG, BCL2, BAX, FLT4, TGFB1
37	Mitochondrial Apoptosis36	8.7	FGF4, FGF2, FLT4, FADD, IGF2, GNRH1
38	Cellular Apoptosis Pathway36	8.7	FADD, IGF2, GNRH1, PDGFRA, FGF4, FGF2
39	Small cell lung cancer20	8.7	RARB, ITGB1, RB1, TP53, ITGA3, CDK2
40	JNK Pathway36	8.7	ZNF354A, FLT4, PDGFRA, TEAD4, TP53, FGF4
41	Pancreatic Adenocarcinoma36	8.6	CCND2, GNRH1, KIT, CDKN2C, TP53, KITLG
42	ERK Signaling36	8.6	IGF2, ESR2, GNRH1, CREB1, PDGFRA, TGFB1
43	Tec Kinases Signaling36	8.3	ITGB1, ITGA3, ITGAL, FGF2, FADD, IGF2
44	JAK-STAT Pathway36	8.2	BAX, FGF4, FGF2, UBC, FLT4, IGF2
45	Rho Family GTPases36	8.2	BCL2, KITLG, VIM, ITGAL, ITGA3, BAX
46	PAK Pathway36	8.1	FLT4, BAX, VEGFC, KITLG, KIT, BCL2
47	p38 Signaling36	8.1	TNFRSF8, CSF3, CREB1, PDGFRA, TGFB1, BAX
48	MAPK Signaling36	7.9	TGFB1, KIT, STAT3, ITGB1, PDGFRA, CREB1
49	Molecular Mechanisms of Cancer36	7.1	VEGFC, RB1, KITLG, IGF2, MYC, RARB
50	Pathways in cancer20	6.6	JUP, CDK2, ITGB1, GSTP1, FGF2, FGF4

Compounds related to seminoma according to GeneDecks:

(show top 50)    (show all 331)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.8	CDK2, ERVK-6, KRT18, TOP1, DNMT1
2	cyclophosphamide32 34 9 9	13.8	MVP, ITGAL
3	dmso32	10.7	KITLG, VIM, CGA, CGB5, ALPP, GNRH1
4	glucose32	10.7	KIT, BRAF, VEGFC, LGALS1, CGB, MGMT
5	rapamycin32 42	11.7	KIT, KITLG, RB1, VIM, BRAF, LGALS1
6	vincristine32 34 9 9	13.4	KIT, CGB, CGB5, MGMT, FGF2, AFP
7	h2o232	10.2	KITLG, SERPINB2, CGA, CGB5, ITGAL, ICAM1
8	heparin32 9 18 9	13.0	KITLG, SERPINB2, VIM, VEGFC, LGALS1, CHKB
9	arginine32	9.7	RET, BRAF, LNPEP, RARB, LGALS1, CHKB
10	zinc32 18	10.6	ZNF354A, KLF4, RB1, LNPEP, RARB, ZFP42
11	aspartate32	9.4	RET, VIM, BRAF, CHKB, CGA, FASLG
12	pge232	9.2	SELE, SERPINB2, VCAM1, LNPEP, CGA, CGB5
13	cysteine32	9.1	RARB, LGALS1, CHKB, CGB, ITGB1, GUCA1A
14	ly29400232	9.1	RET, SELE, FGF2, FASLG, CCNA2, ICAM1
15	hydroxyurea32 9 9	11.0	KIT, KITLG, VCAM1, MYC, RAD17, CGB5
16	estradiol32 9 18 9	11.9	KITLG, RB1, VIM, VEGFC, RARB, CHKB
17	lipid32	8.8	RET, KITLG, RB1, SELE, SERPINB2, VIM
18	12-o-tetradecanoylphorbol 13-acetate32	8.8	RET, RB1, SERPINB2, BRAF, MYC, RARB
19	alanine32	8.8	RET, KITLG, SELE, BRAF, VCAM1, LNPEP
20	azathioprine32 34 9 9	11.8	VIM, RARB, RASSF1, CHKB, ITGAL, MGMT
21	ribonucleic acid32	8.7	RET, KIT, KITLG, SERPINB2, VEGFC, MYC
22	creatinine32	8.6	KITLG, SELE, VIM, CHKB, LDHC, CGA
23	estrogen32	8.6	SERPINB2, VEGFC, RARB, RASSF1, CHKB, CGA
24	imatinib32 34 9 9	11.5	RET, KIT, KITLG, BRAF, MYC, BCL2
25	cyclosporin a32 42	9.4	KITLG, SERPINB2, MYC, CHKB, MVP, CGA
26	calcitriol32 42 9 18 9	12.4	KITLG, RB1, MYC, RARB, CDK2, ITGAL
27	camptothecin32 42 9 9	11.4	RB1, MYC, BCL2, MVP, BAX, CDK2
28	mitomycin c32	8.4	RB1, VCAM1, MVP, XPA, MGMT, FGF2
29	progesterone32 42 9 18 9	12.3	KIT, RB1, SERPINB2, BRAF, VEGFC, LNPEP
30	agarose32	8.2	KIT, KITLG, MYC, BCL2, LGALS1, CHKB
31	matrigel32	8.1	RB1, SELE, SERPINB2, VIM, BRAF, VEGFC
32	carboplatin32 34 9 9	11.1	KITLG, RB1, LNPEP, BCL2, CGA, MGMT
33	sb 20358032 42	9.1	RB1, SELE, VIM, BRAF, VCAM1, BCL2
34	doxorubicin32 34 9 9	10.8	KIT, KITLG, SELE, VIM, MVP, CGA
35	methotrexate32 34 42 9 9	11.8	KIT, KITLG, RB1, SELE, VIM, CHKB
36	lactate32	7.8	KIT, KITLG, SELE, VIM, VCAM1, CHKB
37	retinoid32	7.6	VIM, MYC, RARB, BCL2, LGALS1, BAX
38	etoposide32 42 9 9	10.4	RB1, SELE, MYC, BCL2, LGALS1, MVP
39	adriamycin32	7.1	RB1, VIM, MYC, BCL2, MVP, BAX
40	phosphatidylinositol32	7.1	RET, KIT, KITLG, RB1, BRAF, VEGFC
41	testosterone32 9 18 9	10.1	RET, KIT, KITLG, RB1, SELE, VIM
42	5fluorouracil32	6.8	KIT, KITLG, RB1, SELE, BCL2, MVP
43	docetaxel32 34 9 9	9.7	KIT, MYC, BCL2, MVP, BAX, GSTP1
44	butyrate32	6.6	KLF4, RET, KITLG, RB1, VIM, MYC
45	thymidine32 18	7.4	KLF4, REG1A, KIT, KITLG, RB1, VEGFC
46	tamoxifen32 34 9 9	9.2	SELE, VIM, VCAM1, MYC, BCL2, CHKB
47	retinoic acid32 42 18	7.9	RET, KIT, KITLG, RB1, SERPINB2, BRAF
48	vegf32	5.7	RET, KIT, KITLG, SELE, SERPINB2, BRAF
49	genistein32 9 18 9	8.5	REG1A, RET, KITLG, RB1, SELE, VIM
50	actinomycin d32	4.9	KIT, KITLG, RB1, SELE, SERPINB2, VIM

Cellular components related to seminoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	viral capsid	GO:019028	10.4	ERVK-6, ERVK-5, ERVK-10
2	anchored to membrane	GO:031225	10.4	GFRA1, PLAUR, ALPPL2, ALPP, ALPL, ALPI
3	transcription factor complex	GO:005667	10.0	SOX2, SOX17, HIF1A, CREB1, SMAD4, CDK2
4	external side of plasma membrane	GO:009897	9.3	PTPRC, ICAM1, GPR125, FAS, FASLG, ITGB1
5	cell surface	GO:009986	8.6	PROM1, TGFB1, PLAUR, PLAU, ALPP, GPR98
6	extracellular region	GO:005576	8.3	GNRH1, IGFBP2, IGF2, ENTPD6, FAS, ESR2
7	extracellular space	GO:005615	8.0	PLAU, GNRH1, ALPL, ICAM1, TGFB1, PROM1
8	nucleoplasm	GO:005654	7.8	CREB1, SMAD4, TEAD4, TP53, HIF1A, TOP1
9	plasma membrane	GO:005886	7.3	ERVK-6, ERVK-5, ERVK-10, ERVW-1, ESR1, GJB2
10	cytoplasm	GO:005737	6.0	AFP, PIWIL1, SMAD4, CTAG1A, DAZL, DAPK1
11	nucleus	GO:005634	4.9	SMAD4, CREB1, PDGFRA, WDR77, ZNF85, HIF1A

Biological processes related to seminoma according to GeneDecks:

(show all 39)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:007267	10.7	TFAP2C, ESR2, GJB2, GJA1, GNRH1, FASLG
2	somatic stem cell maintenance	GO:035019	10.5	POU5F1, SOX2, TFAP2C, APC, NANOG
3	endodermal cell fate specification	GO:001714	10.5	POU5F1, SOX2, NANOG
4	positive regulation of MAPK cascade	GO:043410	10.4	SOX2, PTPRC, IGF2, FLT4, ITGB1, KIT
5	germ cell programmed cell death	GO:035234	10.4	KIT, KITLG, BAX
6	hemoglobin biosynthetic process	GO:042541	10.3	EPO, HIF1A, INHBA, INHA
7	detection of mechanical stimulus involved in sensory perception of sound	GO:050910	10.2	KIT, MYC, GPR98, SOX2
8	male gonad development	GO:008584	10.2	TFAP2C, DMRT1, INHBA, INHA, BCL2, ZFP42
9	positive regulation of gene expression	GO:010628	10.2	DNMT1, TFAP2A, TGFB1, KRAS, PLAUR, GJA1
10	regulation of gene expression	GO:010468	10.1	POU5F1, SOX2, HIF1A, GNRH1, NANOG
11	leukocyte cell-cell adhesion	GO:007159	10.0	PTPRC, ICAM1, ITGB1, ITGAL, VCAM1, SELE
12	positive regulation of phospholipase C activity	GO:010863	9.9	PDGFRA, FGF2, KIT
13	positive regulation of cell division	GO:051781	9.9	TGFB1, IGF2, APC, FGF4, FGF2, VEGFC
14	ovarian follicle development	GO:001541	9.9	ESR2, ICAM1, CCND2, INHBA, INHA, BAX
15	Ras protein signal transduction	GO:007265	9.9	KRAS, TP53, CCNA2, FGF2, CDK2, RASSF1
16	response to growth factor stimulus	GO:070848	9.9	SOX2, FAS, FASLG, MYC
17	positive regulation of cell migration	GO:030335	9.8	TGFB1, PDPN, PDGFRA, APC, ITGB1, CDH13
18	regulation of cell cycle	GO:051726	9.8	PTPRC, FGF2, INHA, ITGB1, BAX, NANOS3
19	negative regulation of epithelial cell proliferation	GO:050680	9.6	RB1, ESR2, KRT4, TGFB1, SOX2
20	negative regulation of fibroblast proliferation	GO:048147	9.3	MYC, BAX, GSTP1, TP53
21	cell cycle arrest	GO:007050	9.3	APC, TP53, TGFB1, SOX2, INHBA, INHA
22	activation of pro-apoptotic gene products	GO:008633	9.2	FAS, FADD, FASLG, BAX, BCL2, MYC
23	response to estradiol stimulus	GO:032355	9.2	STAT3, TGFB1, HMBS, ESR1, IGFBP2, CCND2
24	response to gamma radiation	GO:010332	9.1	PTPRC, TP53, BAX, BCL2, MYC
25	response to DNA damage stimulus	GO:006974	9.1	TOP2A, TP53, APC, BAX, BCL2, RASSF1
26	positive regulation of apoptotic process	GO:043065	9.0	ESR2, TP53, TNFRSF8, PTPRC, TOP2A, FAS
27	negative regulation of cell proliferation	GO:008285	9.0	GJA1, TP53, TNFRSF8, SMAD4, TGFB1, TFAP2A
28	anti-apoptosis	GO:006916	9.0	EPO, DAPK1, GNRH1, FAS, GSTP1, UBC
29	negative regulation of apoptotic process	GO:043066	9.0	TP53, PLAUR, KRT18, TFAP2A, EPO, APC
30	positive regulation of cell proliferation	GO:008284	8.9	FASLG, IGF2, PDGFRA, KRAS, WDR77, TGFB1
31	neuron apoptotic process	GO:051402	8.9	TP53, FAS, BAX, BCL2, RB1
32	negative regulation of cell growth	GO:030308	8.9	SOX17, TGFB1, SMAD4, TP53, ESR2, FGF2
33	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.6	SMAD4, TGFB1, TFAP2A, DNMT1, STAT3, SOX17
34	virus-host interaction	GO:019048	8.3	STAT3, TGFB1, TOP1, KRT18, PDGFRA, CREB1
35	response to drug	GO:042493	8.0	VEGFC, ICAM1, HMBS, CREB1, TOP1, TOP2A
36	positive regulation of transcription, DNA-dependent	GO:045893	7.7	CREB1, HIF1A, TGFB1, TFAP2A, STAT3, SOX17
37	signal transduction	GO:007165	7.6	TNFRSF8, ESR2, ESR1, GJA1, GNRH1, CREB1
38	apoptotic process	GO:006915	7.5	FADD, FAS, GJA1, TP53, DAPK1, KRT18
39	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.0	SMAD4, CREB1, HIF1A, TOP2A, TGFB1, TFAP2A

Molecular functions related to seminoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	alkaline phosphatase activity	GO:004035	10.7	ALPPL2, ALPP, ALPL, ALPI
2	core promoter proximal region sequence-specific DNA binding	GO:000987	10.4	TFAP2A, SMAD4, DMRT1, KLF4
3	hormone activity	GO:005179	10.0	EPO, GNRH1, IGF2, INHBA, INHA, CGB
4	growth factor activity	GO:008083	9.5	GDF3, CSF3, TGFB1, IGF2, FGF4, FGF2
5	transcription regulatory region DNA binding	GO:044212	9.2	SOX17, SOX2, SOX5, POU5F1, STAT3, TFAP2A
6	protein kinase binding	GO:019901	8.6	STAT3, HIF1A, PTPRC, TP53, CCND2, CCNA2
7	identical protein binding	GO:042802	8.1	ESR1, TP53, DAZL, SMAD4, NME1, FAS
8	enzyme binding	GO:019899	8.1	CSF3, TGFB1, TOP2A, HIF1A, PLAUR, TP53
9	protein heterodimerization activity	GO:046982	7.8	ENO2, TP53, HIF1A, TOP2A, TGFB1, SOX5
10	sequence-specific DNA binding transcription factor activity	GO:003700	7.7	SMAD4, CREB1, ZNF85, HIF1A, TFAP2C, STAT3
11	protein binding	GO:005515	2.2	IGFBP2, CTAG1A, SMAD4, CREB1, PLAU, PLAUR