MCID: SMN007
MIFTS: 48

Seminoma malady

Summaries for Seminoma

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Seminoma (also known as pure seminoma or classical seminoma) is a germ cell tumor of the testis or, more... more...

MalaCards: Seminoma, also known as seminoma, pure, is related to testicular cancer and gonadoblastoma. An important gene associated with Seminoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Selected targets of Oct-3/4 and NAD metabolism. The compounds paraffin and lactate have been mentioned in the context of this disorder. Affiliated tissues include testis, lymph node and prostate.

Description from OMIM:46 273300

Aliases & Classifications for Seminoma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM
See all sources

Aliases & Descriptions:

seminoma 8 42 10 44 60
seminoma, pure 8


External Ids:

Disease Ontology8 DOID:4440
MeSH34 D018239
NCIt39 C9309
OMIM46 273300

Related Diseases for Seminoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Seminoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1testicular cancer30.7AFP, ALPP
2gonadoblastoma30.3KIT, ALPP, ALPPL2
3sertoli cell tumor30.3ALPP
4sarcoma30.2CGB, SSX2, MAGEA1, MAGEA4, KIT
5male germ cell tumor, somatic30.1DNMT3L, SLC2A6
6embryonal cancer29.9ALPPL2, ALPP, AFP
7endodermal sinus tumor29.9AFP
8squamous cell carcinoma29.9ALPP, MAGEA4, MAGEA1, CGB, CGB7
9hepatitis29.9AFP, MAGEA1, ALPP
10choriocarcinoma29.7ALPPL2, ALPP, AFP, CGB, CGB7
11hepatitis b29.7ALPPL2, ALPP, MAGEA4, MAGEA1, AFP, CGB
12adenocarcinoma29.7CGB7, CGB, AFP, MAGEA1, MAGEA4
13leukemia29.7ALPPL2, ALPP, TCL1A, KIT, MAGEA1, CGB
14hypercalcemia29.7ALPP, ALPPL2
15testis seminoma10.7
16mediastinitis10.6
17extragonadal seminoma10.5
18cryptorchidism10.3
19mediastinum seminoma10.3
20prostatitis10.3
21androgen insensitivity syndrome10.2
22testicular spermatocytic seminoma10.2
23gonadal dysgenesis10.2
24in situ carcinoma10.2
25spermatocytoma10.2
26klinefelter's syndrome10.1
27intratubular embryonal carcinoma10.1
28burns10.1
29exophthalmos10.1
30orchitis10.1
31tubular variant testicular seminoma10.1
32pseudoglandular variant testicular seminoma10.1
33malignant sertoli cell tumor10.1
34persistent mullerian duct syndrome10.1
35hermaphroditism10.1
36malignant teratoma10.1
37peritonitis10.1
38sarcoidosis10.1
39breast cancer10.0CGB7, CGB, SSX2, MAGEA1, MAGEA4, KIT
40teratoma10.0CGB7, CGB, AFP, KIT, ALPP, ALPPL2
41germinoma10.0CGB, AFP, KIT, ALPP
42myeloma10.0MAGEA1, TCL1A, ALPP, ALPPL2
43cholangiocarcinoma10.0ALPPL2, ALPP, AFP, CGB
44ovarian cancer10.0CGB, AFP, SSX2, MAGEA1
45dysgerminoma10.0ALPP, KIT, AFP
46gestational trophoblastic neoplasm10.0CGB7, CGB, ALPP
47liver cirrhosis10.0AFP, MAGEA1, MAGEA4, ALPP
48germ cell cancer10.0AFP, ALPP, ALPPL2
49hypophosphatasia10.0ALPP, ALPPL2
50synovial sarcoma10.0SSX2, MAGEA1, KIT

Graphical network of the top 20 diseases related to Seminoma:



Diseases related to seminoma

Clinical Features for Seminoma

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

273300

Drugs & Therapeutics for Seminoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Seminoma

Drug clinical trials:

Search ClinicalTrials for Seminoma

Search NIH Clinical Center for Seminoma

Search CenterWatch for Seminoma

Genetic Tests for Seminoma

About this section

Anatomical Context for Seminoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Seminoma:

32
Testis, Lymph node, Prostate, Kidney, Pineal, Bone, Liver, Spinal cord, Brain, T cells, Testes, Breast, Thyroid, Lung, B cells, Skin, Pancreas, Heart, Bone marrow

Animal Models for Seminoma or affiliated genes

About this section

Publications for Seminoma

About this section
Sources:
50PubMed
See all sources

Articles related to Seminoma:

(show top 50)    (show all 698)
idTitleAuthorsYear
1
Seminoma stage 1: Patterns of care in Europe. (23444928)
2013
2
Isolated late metastasis from testicular seminoma presenting as a parotid gland mass: case report and review of the literature. (23904775)
2013
3
Supernumerary nipple and seminoma: case report and review of polythelia and genitourinary cancers. (23374946)
2013
4
Outcomes in stage I testicular seminoma: a population-based study of 9193 patients. (23633409)
2013
5
A comparison of measured and estimated glomerular filtration rate for carboplatin dose calculation in stage I testicular seminoma. (23864250)
2013
6
Utility of serum tumor markers during surveillance for stage I seminoma. (22517478)
2012
7
Can we rely on PET in the follow-up of advanced seminoma patients? (22507953)
2012
8
Observation Versus Adjuvant Radiation or Chemotherapy in the Management of Stage I Seminoma: Clinical Outcomes and Prognostic Factors for Relapse in a Large US Cohort. (23275274)
2012
9
Two cycles of cisplatin-based chemotherapy for low-volume stage II seminoma: results of a retrospective, single-center case series. (23296381)
2012
10
Successful resection of mediastinal seminoma evaluated the response to induction chemotherapy with fluorodeoxyglucose-positron emission tomography. (21881343)
2012
11
Metastasizing testicular seminoma in a pet rabbit. (22529136)
2012
12
Giant testicular seminoma. (22901819)
2012
13
Synchronous metastatic seminoma and primary retroperitoneal ganglioneuroma: case report and literature review. (22154172)
2011
14
Randomized trial of carboplatin versus radiotherapy for stage I seminoma: mature results on relapse and contralateral testis cancer rates in MRC TE19/EORTC 30982 study (ISRCTN27163214). (21282539)
2011
15
Retrospective multicentre study of carboplatin monotherapy for clinical stage I seminoma. (21438975)
2011
16
Distinctive glycerophospholipid profiles of human seminoma and adjacent normal tissues by desorption electrospray ionization imaging mass spectrometry. (21953186)
2011
17
Synchronous bilateral seminoma. (21301051)
2011
18
Carboplatin does not prevent contralateral testicular tumors in patients with seminoma. (21670458)
2011
19
Immunohistochemistry expression of P53, Ki67, CD30, and CD117 and presence of clinical metastasis at diagnosis of testicular seminoma. (20881837)
2011
20
Malignant seminoma with multiple visceral metastases in a guinea fowl (Numida meleagris) kept in a zoo. (19432019)
2009
21
Identification of ERbeta1 and ERbeta2 in human seminoma, in embryonal carcinoma and in their adjacent intratubular germ cell neoplasia. (19493328)
2009
22
Further characterization of the first seminoma cell line TCam-2. (18050305)
2008
23
Endobronchial metastasis from testicular seminoma. (18836280)
2008
24
Inflammatory myopathy and cancer: rare association of seminoma testes and polymyositis. (18380709)
2008
25
Novel germ cell markers characterize testicular seminoma and fetal testis. (17785371)
2007
26
Complete response after treatment with imatinib in pretreated disseminated testicular seminoma with overexpression of c-KIT. (17976614)
2007
27
Evidence-based guidelines for following stage 1 seminoma. (17437287)
2007
28
Upper gastrointestinal hemorrhage as a rare extragonadal presentation of seminoma of testis. (17430271)
2007
29
Management of low-stage testicular seminoma. (17484918)
2007
30
Diffuse membranous immunoreactivity for podoplanin (D2-40) distinguishes primary and metastatic seminomas from other germ cell tumors and metastatic neoplasms. (17951198)
2007
31
Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors. (17592271)
2007
32
Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. (16397242)
2006
33
Metastatic spermatocytic seminoma--an extremely rare disease: Part 2. (16541488)
2006
34
Dual occurrence of pineal germinoma and testicular seminoma. Case report and review of the literature. (16357500)
2006
35
Long-term results in patients affected by testicular seminoma treated with radiotherapy: risk of second malignancies. (15948542)
2005
36
Adverse effects after radiotherapy for early stage (I,IIa,IIb) seminoma. (15921773)
2005
37
Carboplatin for stage I seminoma and the sword of Damocles. (16260692)
2005
38
Is carboplatin as effective as radiotherapy for the adjuvant treatment of stage I seminoma? (16474542)
2005
39
Primary retroperitoneal seminoma presenting with inferior vena caval obstruction. (16311616)
2005
40
Effect of hypoxia on human seminoma cells. (11956589)
2002
41
Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma. (12210085)
2002
42
The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. (12065688)
2002
43
Modified approach for apoptosis detection reveals changes in apoptotic processes in the seminoma-associated tissue. (14692398)
1999
44
Lepromatous orchitis associated with seminoma. (9934365)
1998
45
Differential expression of a human sperm-specific isozyme in seminoma cells transplanted in Scid-nu(str) mice. (8486524)
1993
46
Pure seminoma arising in androgen insensitivity syndrome (testicular feminization syndrome): a case report and review of the literature. (8093980)
1993
47
Immunohistochemical staining of germ cell tumors and intratubular malignant germ cells of the testis using antibody to placental alkaline phosphatase and a monoclonal anti-seminoma antibody. (1646453)
1991
48
Successful surgical treatment of malignant hypertension due to metastatic seminoma. (6675664)
1983
49
Ultrastructure of gonadoblastoma and disgerminoma (seminoma) in a patient with XY gonadal dysgenesis. (561649)
1977
50
Seminoma in Klinefelter's syndrome with 47, XXY, 15s+ karyotype. (858129)
1977

Genetic Variations for Seminoma

About this section

Expression for genes affiliated with Seminoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Seminoma

Search GEO for disease gene expression data for Seminoma.

Pathways for genes affiliated with Seminoma

About this section
Sources:
12EMD Millipore, 29KEGG
See all sources

Pathways related to Seminoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.6TCL1A, CGB, CGB7
2
NAD metabolism
Hide members
10.6ALPI, ALPPL2, ALPP
310.6ALPI, ALPPL2, ALPP

Compounds for genes affiliated with Seminoma

About this section
Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB
See all sources

Compounds related to Seminoma according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1paraffin4411.0ALPPL2, ALPP, KIT, MAGEA1, AFP
2lactate4411.0CGB7, CGB, AFP, KIT, ALPP
3cisplatin44 49 59 1114.0ALPP, GTF2H2, AFP, CGB, CGB7
4thyroxine44 2412.0CGB7, CGB, AFP, ALPP
5oestriol4411.0AFP, CGB, CGB7
67,8-dihydroneopterin44 2411.9ALPI, ALPPL2, ALPP
7dihydroneopterin triphosphate44 2411.9ALPP, ALPPL2, ALPI
8vas-a4410.9ALPPL2, KIT, DAZL
9dihydroxyacetone44 2411.9ALPP, ALPPL2, ALPI
10methotrexate44 49 1112.9CGB7, CGB, AFP, KIT
11testosterone44 59 11 2413.9CGB7, CGB, AFP, KIT, ALPP
12butyrate4410.9AFP, ALPP, ALPPL2, ALPI
13bleomycin44 1111.8AFP, CGB, CGB7
14phosphoethanolamine4410.8ALPI, ALPP
15hydroxyurea44 49 1112.8ALPP, RAD17, KIT
16vincristine44 49 1112.7KIT, AFP, CGB
17vitamin k24410.7ALPP, AFP
18clomiphene citrate4410.6AFP, CGB
19p-nitrophenyl phosphate4410.6ALPP, ALPI
20ctp4410.5CGB, CGB7
21levamisole44 1111.3ALPPL2, ALPP

GO Terms for genes affiliated with Seminoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.6ALPI, ALPPL2, ALPP

Molecular functions related to Seminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:04687210.8DNMT3L, KIT, ZNF85, ALPP, ALPPL2, ALPI
2alkaline phosphatase activityGO:00403510.3ALPI, ALPPL2, ALPP

Products for genes affiliated with Seminoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Seminoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet