MCID: SNL003
MIFTS: 32

Senile Angioma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Senile Angioma

MalaCards integrated aliases for Senile Angioma:

Name: Senile Angioma 12 14 69
Senile Naevus of Skin 12
Senile Hemangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2495
NCIt 47 C4390
SNOMED-CT 64 11790000 5050001
UMLS 69 C0343082

Summaries for Senile Angioma

MalaCards based summary : Senile Angioma, also known as senile naevus of skin, is related to pseudomyxoma peritonei and mannose-binding lectin protein deficiency. An important gene associated with Senile Angioma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Pathways in cancer. The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and endothelial, and related phenotypes are cellular and embryo

Related Diseases for Senile Angioma

Diseases related to Senile Angioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 pseudomyxoma peritonei 10.7 KIT VIM
2 mannose-binding lectin protein deficiency 10.7 KIT VIM
3 pseudounicornuate uterus 10.7 KIT VIM
4 diffuse meningeal melanocytosis 10.7 KIT VIM
5 sebaceous adenoma 10.6 KIT VIM
6 malignant breast melanoma 10.6 KIT VIM
7 rectal neoplasm 10.6 KIT VIM
8 mesenchymoma 10.6 KIT VIM
9 punctate palmoplantar keratoderma type 2 10.6 KDR KIT
10 prostate disease 10.6 KIT VIM
11 large cell acanthoma 10.6 KIT VIM
12 sublingual gland adenoid cystic carcinoma 10.6 KIT MAP2K1
13 enamel hypoplasia cataract hydrocephaly 10.6 KIT VIM
14 sphenoid sinus squamous cell carcinoma 10.5 KIT THBD
15 cask-related intellectual disability 10.5 KDR KIT
16 polyosteolysis/hyperostosis syndrome 10.5 KIT VIM
17 persian gulf syndrome 10.5 THBD VIM
18 histidine metabolism disease 10.5 KDR KIT
19 childhood pleomorphic rhabdomyosarcoma 10.5 THBD VIM
20 benign familial neonatal epilepsy 10.5 KDR VIM
21 urethral villous adenoma 10.5 KIT THBD
22 extraosseous osteosarcoma 10.4 KDR KIT
23 fibula aplasia complex brachydactyly 10.4 KIT VIM
24 thyroid angiosarcoma 10.4 HBA1 KIT
25 ampulla of vater squamous cell carcinoma 10.4 HBA1 VIM
26 chondroblastoma 10.4 THBD VIM
27 encephalitozoonosis 10.3 HBA1 KIT
28 myoepithelial carcinoma 10.3 KDR KIT VIM
29 cutaneous liposarcoma 10.3 HBA1 KIT
30 chikungunya 10.3 KDR KIT VIM
31 fibrosarcoma of bone 10.3 HBA1 KIT
32 acidophil adenoma 10.3 KIT VIM
33 avian influenza 10.3 KDR THBD
34 extragonadal germ cell cancer 10.3 HBA1 KDR
35 perivascular epithelioid cell tumor 10.3 KIT THBD
36 vesiculobullous skin disease 10.3 HBA1 KDR
37 mucin-rich endometrial endometrioid adenocarcinoma 10.3 HBA1 VIM
38 hypoglossal nerve neoplasm 10.2 KIT VIM
39 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 10.2 HBA1 VIM
40 ossifying fibromyxoid tumor 10.2 HBA1 VIM
41 hydrarthrosis 10.2 HBA1 KIT
42 cystitis 10.2 KDR VIM
43 gastrointestinal stromal tumor 10.2 HSP90AA1 KIT VIM
44 pericardial tuberculosis 10.1 HBA1 VIM
45 hyperandrogenism 10.1 HBA1 THBD
46 segmental odontomaxillary dysplasia 10.1 KDR TF
47 hyperpituitarism 10.0 HBA1 VIM
48 factitious disorder 10.0 HBA1 KDR KIT
49 b-cell lymphomas 10.0
50 lymphoma 10.0

Graphical network of the top 20 diseases related to Senile Angioma:



Diseases related to Senile Angioma

Symptoms & Phenotypes for Senile Angioma

MGI Mouse Phenotypes related to Senile Angioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CCNE1 HSP90AA1 KDR KIT MAP2K1 THBD
2 embryo MP:0005380 9.63 CCNE1 KDR KIT MAP2K1 THBD VIM
3 mortality/aging MP:0010768 9.56 CCNE1 HSP90AA1 KDR KIT MAP2K1 TF
4 reproductive system MP:0005389 9.1 CCNE1 HSP90AA1 KIT MAP2K1 THBD VIM

Drugs & Therapeutics for Senile Angioma

Drugs for Senile Angioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
2
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
3 Antineoplastic Agents, Hormonal Phase 2
4 Gastrointestinal Agents Phase 2
5 Hormones Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Phase II Pilot Study of Octreotide, a Somatostatin Octapeptide Analog, for Gastrointestinal Hemorrhage in Hormone-Refractory Hereditary Hemorrhagic Telangiectasia and Senile Ectasia Completed NCT00004327 Phase 2 octreotide
2 Comparison of Electrodessication, Potassium Titanyl Phosphate (KTP) Laser and Pulsed Dye Laser for Treatment of Cherry Angiomata Completed NCT00791908

Search NIH Clinical Center for Senile Angioma

Genetic Tests for Senile Angioma

Anatomical Context for Senile Angioma

MalaCards organs/tissues related to Senile Angioma:

39
Skin, B Cells, Endothelial

Publications for Senile Angioma

Articles related to Senile Angioma:

id Title Authors Year
1
Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. ( 21686374 )
2009
2
Prichard's structures of the fossa ovalis are age-related phenomena composed of nonreplicating endothelial cells: the cardiac equivalent of cutaneous senile angioma. ( 18092955 )
2007
3
Senile angioma-like eruption: a skin manifestation of intravascular large B cell lymphoma. ( 15316168 )
2004
4
Intravascular large B cell lymphoma diagnosed by senile angioma biopsy. ( 12583632 )
2003
5
[Clinical features and histology of angioma. III. Histology and pathogenesis of senile angioma]. ( 13198143 )
1954

Variations for Senile Angioma

Expression for Senile Angioma

Search GEO for disease gene expression data for Senile Angioma.

Pathways for Senile Angioma

Pathways related to Senile Angioma according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 HSP90AA1 KDR KIT MAP2K1 VIM
2 12.22 CCNE1 HSP90AA1 KIT MAP2K1
3
Show member pathways
12.12 CCNE1 HSP90AA1 KDR KIT MAP2K1
4
Show member pathways
12.1 HSP90AA1 KDR MAP2K1 TF
5
Show member pathways
12.08 HSP90AA1 KDR MAP2K1
6
Show member pathways
12.01 CCNE1 HSP90AA1 MAP2K1
7
Show member pathways
12.01 HSP90AA1 KDR MAP2K1
8 11.72 HSP90AA1 KDR THBD
9 11.56 CCNE1 HSP90AA1 KDR KIT MAP2K1
10 11.3 HSP90AA1 IVL MAP2K1
11 11.19 HSP90AA1 KDR
12
Show member pathways
11.05 KDR KIT MAP2K1
13 11.01 IVL THBD

GO Terms for Senile Angioma

Cellular components related to Senile Angioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.13 KDR MAP2K1 TF
2 endocytic vesicle lumen GO:0071682 8.62 HBA1 HSP90AA1

Biological processes related to Senile Angioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.62 CCNE1 KDR KIT MAP2K1
2 embryonic hemopoiesis GO:0035162 9.16 KDR KIT
3 ERK1 and ERK2 cascade GO:0070371 8.96 MAP2K1
4 Bergmann glial cell differentiation GO:0060020 8.96 MAP2K1 VIM
5 peptidyl-tyrosine phosphorylation GO:0018108 8.92 HSP90AA1 KDR KIT MAP2K1

Molecular functions related to Senile Angioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.85 CCNE1 HBA1 HSP90AA1 IVL KDR KIT
2 kinase activity GO:0016301 9.56 CCNE1 KDR KIT MAP2K1
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 8.96 KDR KIT
4 protein tyrosine kinase activity GO:0004713 8.92 HSP90AA1 KDR KIT MAP2K1

Sources for Senile Angioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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