MCID: SNL003
MIFTS: 35

Senile Angioma

Categories: Skin diseases, Cancer diseases

Aliases & Classifications for Senile Angioma

MalaCards integrated aliases for Senile Angioma:

Name: Senile Angioma 12 14 69
Senile Naevus of Skin 12
Senile Hemangioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2495
NCIt 46 C4390
SNOMED-CT 64 11790000 5050001
UMLS 69 C0343082

Summaries for Senile Angioma

MalaCards based summary : Senile Angioma, also known as senile naevus of skin, is related to mast-cell sarcoma and malignant mixed mullerian tumor. An important gene associated with Senile Angioma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Endometrial cancer. The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and endothelial, and related phenotypes are cellular and embryo

Related Diseases for Senile Angioma

Diseases related to Senile Angioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 mast-cell sarcoma 10.4 KIT VIM
2 malignant mixed mullerian tumor 10.4 KIT VIM
3 benign breast phyllodes tumor 10.4 KIT VIM
4 perivascular epithelioid cell tumor 10.4 KIT VIM
5 perineurioma 10.4 KIT VIM
6 dermoid cyst 10.4 KIT VIM
7 pulmonary vein stenosis 10.4 KDR KIT
8 ovarian melanoma 10.4 KIT MAP2K1
9 embryonal sarcoma 10.4 KIT VIM
10 smooth muscle tumor 10.4 KIT VIM
11 cavernous hemangioma 10.3 KDR VIM
12 polymorphous low-grade adenocarcinoma 10.3 KIT VIM
13 8p11 myeloproliferative syndrome 10.3 KDR KIT
14 rete testis adenocarcinoma 10.3 KIT THBD
15 sarcomatoid mesothelioma 10.3 THBD VIM
16 adenomatoid tumor 10.3 THBD VIM
17 rete testis neoplasm 10.3 KIT THBD
18 mast-cell leukemia 10.3 KDR KIT
19 fibromatosis 10.3 KIT VIM
20 fibrosarcoma of bone 10.2 KDR KIT
21 breast angiosarcoma 10.2 HBA1 KIT
22 adenoid squamous cell carcinoma 10.2 HBA1 VIM
23 angiomyoma 10.2 HBA1 KIT
24 benign mesothelioma 10.2 THBD VIM
25 spindle cell liposarcoma 10.2 HBA1 KIT
26 mesenchymal cell neoplasm 10.2 HBA1 KIT
27 angiosarcoma 10.2 KDR KIT VIM
28 skin hemangioma 10.1 HBA1 KDR
29 capillary hemangioma 10.1 HBA1 KDR
30 congenital epulis 10.1 HBA1 VIM
31 hemangiopericytoma, malignant 10.1 HBA1 VIM
32 ovarian brenner tumor 10.1 KIT THBD
33 b-cell lymphomas 10.1
34 lymphoma 10.1
35 intravascular large b-cell lymphoma 10.1
36 liver angiosarcoma 10.1 HBA1 VIM
37 malignant dermis tumor 10.1 HBA1 KIT
38 hemangioma 10.1
39 gastrointestinal stromal tumor 10.1 HSP90AA1 KIT VIM
40 meninges hemangiopericytoma 10.0 HBA1 VIM
41 pericardium cancer 10.0 HBA1 THBD
42 desmoplastic small round cell tumor 10.0 THBD VIM
43 glomangioma 10.0 HBA1 VIM
44 radiation proctitis 10.0 KDR TF
45 vascular cancer 10.0 HBA1 KDR KIT
46 neurilemmoma 9.9 KIT VIM
47 pericardial mesothelioma 9.9 HBA1 THBD VIM
48 aging 9.9
49 endotheliitis 9.9
50 connective tissue cancer 9.8 HBA1 KIT

Graphical network of the top 20 diseases related to Senile Angioma:



Diseases related to Senile Angioma

Symptoms & Phenotypes for Senile Angioma

MGI Mouse Phenotypes related to Senile Angioma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CCNE1 HSP90AA1 KDR KIT MAP2K1 THBD
2 embryo MP:0005380 9.63 CCNE1 KDR KIT MAP2K1 THBD VIM
3 mortality/aging MP:0010768 9.56 CCNE1 HSP90AA1 KDR KIT MAP2K1 TF
4 reproductive system MP:0005389 9.1 HSP90AA1 KIT MAP2K1 THBD VIM CCNE1

Drugs & Therapeutics for Senile Angioma

Drugs for Senile Angioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 2 83150-76-9 6400441 383414
2
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
3 Antineoplastic Agents, Hormonal Phase 2
4 Gastrointestinal Agents Phase 2
5 Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Pilot Study of Octreotide, a Somatostatin Octapeptide Analog, for Gastrointestinal Hemorrhage in Hormone-Refractory Hereditary Hemorrhagic Telangiectasia and Senile Ectasia Completed NCT00004327 Phase 2 octreotide
2 Comparison of Electrodessication, Potassium Titanyl Phosphate (KTP) Laser and Pulsed Dye Laser for Treatment of Cherry Angiomata Completed NCT00791908

Search NIH Clinical Center for Senile Angioma

Genetic Tests for Senile Angioma

Anatomical Context for Senile Angioma

MalaCards organs/tissues related to Senile Angioma:

38
Skin, B Cells, Endothelial

Publications for Senile Angioma

Articles related to Senile Angioma:

# Title Authors Year
1
Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. ( 21686374 )
2009
2
Prichard's structures of the fossa ovalis are age-related phenomena composed of nonreplicating endothelial cells: the cardiac equivalent of cutaneous senile angioma. ( 18092955 )
2007
3
Senile angioma-like eruption: a skin manifestation of intravascular large B cell lymphoma. ( 15316168 )
2004
4
Intravascular large B cell lymphoma diagnosed by senile angioma biopsy. ( 12583632 )
2003
5
[Clinical features and histology of angioma. III. Histology and pathogenesis of senile angioma]. ( 13198143 )
1954

Variations for Senile Angioma

Expression for Senile Angioma

Search GEO for disease gene expression data for Senile Angioma.

Pathways for Senile Angioma

Pathways related to Senile Angioma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 HSP90AA1 KDR KIT MAP2K1 VIM
2
Show member pathways
12.54 CCNE1 HSP90AA1 KDR KIT MAP2K1
3 12.43 CCNE1 HSP90AA1 KIT MAP2K1
4
Show member pathways
12.16 HSP90AA1 KDR MAP2K1 TF
5
Show member pathways
12.09 HSP90AA1 KDR MAP2K1
6
Show member pathways
12.03 CCNE1 HSP90AA1 MAP2K1
7
Show member pathways
12.03 HSP90AA1 KDR MAP2K1
8
Show member pathways
11.84 CCNE1 HSP90AA1 KDR KIT MAP2K1
9 11.69 HSP90AA1 KDR THBD
10 11.3 HSP90AA1 IVL MAP2K1
11 11.21 HSP90AA1 KDR
12 11.16 KDR MAP2K1
13
Show member pathways
11.05 KDR KIT MAP2K1
14 11.03 IVL THBD
15 10.66 KDR KIT MAP2K1 VIM

GO Terms for Senile Angioma

Cellular components related to Senile Angioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.13 KDR MAP2K1 TF
2 endocytic vesicle lumen GO:0071682 8.62 HBA1 HSP90AA1

Biological processes related to Senile Angioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.62 CCNE1 KDR KIT MAP2K1
2 ERK1 and ERK2 cascade GO:0070371 9.26 KDR MAP2K1
3 embryonic hemopoiesis GO:0035162 9.16 KDR KIT
4 Bergmann glial cell differentiation GO:0060020 8.96 MAP2K1 VIM
5 peptidyl-tyrosine phosphorylation GO:0018108 8.92 HSP90AA1 KDR KIT MAP2K1

Molecular functions related to Senile Angioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 CCNE1 HBA1 HSP90AA1 IVL KDR KIT
2 kinase activity GO:0016301 9.62 CCNE1 KDR KIT MAP2K1
3 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.16 KDR KIT
4 scaffold protein binding GO:0097110 9.13 HSP90AA1 MAP2K1 VIM
5 protein tyrosine kinase activity GO:0004713 8.92 HSP90AA1 KDR KIT MAP2K1

Sources for Senile Angioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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