Aliases & Classifications for Senile Cataract

MalaCards integrated aliases for Senile Cataract:

Name: Senile Cataract 12 51 14

Classifications:



External Ids:

Disease Ontology 12 DOID:9669
ICD10 32 H25
ICD9CM 34 366.1 366.10
NCIt 46 C35012
UMLS 69 C0036646

Summaries for Senile Cataract

MalaCards based summary : Senile Cataract is related to nuclear senile cataract and cortical senile cataract. An important gene associated with Senile Cataract is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Selenium Micronutrient Network and NRF2 pathway. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes.

Related Diseases for Senile Cataract

Diseases related to Senile Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 nuclear senile cataract 12.2
2 cortical senile cataract 12.1
3 immature cataract 11.5
4 cataract 11.0
5 mature cataract 11.0
6 hearing loss, noise-induced 10.4 GSTM1 GSTT1
7 isolated cleft lip 10.4 GSTM1 GSTT1
8 drug-induced hepatitis 10.4 GSTM1 GSTT1
9 leukoplakia 10.4 GSTM1 GSTT1
10 arteritic anterior ischemic optic neuropathy 10.4 GSTM1 GSTT1
11 oligospermia 10.3 GSTM1 GSTT1
12 diffuse gastric cancer 10.3 GSTM1 GSTT1
13 lymphosarcoma 10.3 G6PD GSR
14 morgagni cataract 10.3 CRYAA GSR
15 congenital methemoglobinemia 10.3 G6PD SOD1
16 aging 10.3
17 neonatal jaundice 10.3 G6PD GSTM1
18 asbestosis 10.3 GSTM1 GSTT1
19 methemoglobinemia 10.2 G6PD SOD1
20 ischemic optic neuropathy 10.2 G6PD GSTM1 GSTT1
21 oral submucous fibrosis 10.2 GSTM1 GSTT1
22 sister chromatid exchange, frequency of 10.2 GSTM1 GSTT1 XRCC1
23 oral leukoplakia 10.2 GSTM1 GSTT1 XRCC1
24 mutagen sensitivity 10.2 GSTM1 GSTT1 XRCC1
25 xeroderma pigmentosum, complementation group d 10.2 GSTM1 GSTT1 XRCC1
26 acute lymphoblastic leukemia, childhood 10.2 GSTM1 GSTT1 XRCC1
27 varicocele 10.2 GSTM1 GSTT1
28 larynx cancer 10.2 GSTM1 GSTT1 XRCC1
29 eales disease 10.1 SERPINF1 SOD1
30 early-onset nuclear cataract 10.1 BFSP1 CRYAA
31 meningococcal infection 10.1 G6PD GSR SOD1
32 basal cell carcinoma 10.0 GSTM1 GSTT1 XRCC1
33 open-angle glaucoma 10.0
34 koro 10.0 ALB G6PD
35 parotitis 10.0 ALB G6PD
36 kernicterus 10.0 ALB G6PD
37 ariboflavinosis 10.0 ALB GSR
38 nasopharyngeal carcinoma 10.0 GSTM1 GSTT1 XRCC1
39 glaucoma, primary open angle 9.9
40 macular degeneration, age-related, 1 9.9
41 microvascular complications of diabetes 5 9.9
42 diabetes mellitus 9.9
43 meningitis and encephalitis 9.9 ALB SOD1
44 multinodular goiter 9.9 GSR SOD1
45 arcus corneae 9.8 ALB CRYAA
46 blood group--diego system 9.8
47 strabismus 9.8
48 body mass index quantitative trait locus 11 9.8
49 body mass index quantitative trait locus 9 9.8
50 body mass index quantitative trait locus 8 9.8

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to Senile Cataract

Symptoms & Phenotypes for Senile Cataract

Drugs & Therapeutics for Senile Cataract

Drugs for Senile Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Dipivefrin Approved Phase 4 52365-63-6 3105
5 Racepinephrine Approved Phase 4 329-65-7
6 Analgesics Phase 4
7 Central Nervous System Depressants Phase 4
8 Adrenergic Agents Phase 4
9 Adrenergic Agonists Phase 4
10 Neurotransmitter Agents Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Analgesics, Non-Narcotic Phase 4
13 Anesthetics Phase 4
14 Peripheral Nervous System Agents Phase 4
15 Epinephryl borate Phase 4
16 Anti-Inflammatory Agents Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 Ketorolac Tromethamine Phase 4
19 Antirheumatic Agents Phase 4
20 Ophthalmic Solutions Phase 2
21 Pharmaceutical Solutions Phase 2
22
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
23
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759
24
Phenylephrine Approved 59-42-7 6041
25
Oxymetazoline Approved, Investigational 1491-59-4 4636
26
Ephedrine Approved 299-42-3 9294
27
Iodine Approved, Investigational 7553-56-2 807
28
Tropicamide Approved, Investigational 1508-75-4 5593
29
Pseudoephedrine Approved 90-82-4 7028
30
Menthol Approved 2216-51-5 16666
31
Povidone-iodine Approved 25655-41-8
32 Propoxycaine Approved 86-43-1
33
Povidone Approved 9003-39-8
34
Glycerol Approved, Investigational 56-81-5 753
35
Tobramycin Approved, Investigational 32986-56-4 36294 5496
36
Dinoprostone Approved 363-24-6 5280360
37 cadexomer iodine
38 insulin
39 Dexamethasone acetate 1177-87-3
40 glucocorticoids
41
protease inhibitors
42 Respiratory System Agents
43 Adjuvants, Immunologic
44 Adrenergic alpha-Agonists
45 Muscarinic Antagonists
46 Mydriatics
47 Sodium Channel Blockers
48 Cholinergic Agents
49 Cholinergic Antagonists
50 Nasal Decongestants

Interventional clinical trials:

(show top 50) (show all 52)

# Name Status NCT ID Phase Drugs
1 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015 Phase 4
2 Outcomes of Phacoemulsification With Torsional Ultrasound Completed NCT01010490 Phase 4
3 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria Completed NCT02150460 Phase 4
4 Effect of Optic Edge Design in a Silicone Intraocular Lens on Posterior Capsule Opacification Completed NCT00428363 Phase 4
5 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac
6 Effect of Minimising Ultrasound Power to 1% During Cataract Surgery on Corneal Endothelium. Unknown status NCT01259349 Phase 3
7 Evaluation of Seelens AF, an Aspheric Intra-Ocular Lens Unknown status NCT00825747 Phase 3
8 Collaborative Italian-American Clinical Trial of Nutritional Supplements and Age-related Cataract (CTNS) Completed NCT00309387 Phase 3
9 Safety and Efficacy Study of an Ophthalmic Solution in Patients With Age-Related Cataract Unknown status NCT00793091 Phase 2 C-KAD Ophthalmic Solution;Placebo
10 Dose-Ranging Study of an Ophthalamic Solution in Patients With Loss of Visual Function Due to Age-Related Nuclear Cataract Unknown status NCT00825721 Phase 2 LiquiTears;C-KAD Ophthalmic Solution;C-KAD Ophthalmic Solution;C-KAD Ophthalmic Solution
11 Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population Completed NCT01142960
12 Efficacy of FLACS USFREE Compared to Traditional Surgery Using Ultrasound. Completed NCT03050008
13 Subfoveal Choroidal Thickness After Surgery for Age-related Cataracts Completed NCT02895074 Tropicamide;Proparacaine hydrochloride
14 Pilot Study: Dynamic Light Scattering Device for Studying Early Changes in Cataract Completed NCT00067483
15 Release of Proinflammatory Cytokines (IL-1β, IL-6) and Total-prostaglandin (PG) Following Femtosecond Laser-assisted Cataract Surgery Compared to Manual Cataract Surgery Completed NCT03390361
16 A Prospective Observational Case Series of a Four-ring-haptic Acrylic One-piece IOL Completed NCT01244373
17 Phaco Versus Small Incision Cataract Surgery (SICS) Health Economic Study Completed NCT00762606
18 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
19 Intraocular Pressure Variation by Pneumatic Tonometer Before and After Phacoemulsification Completed NCT03016507
20 Anterior Capsule Polishing Effect on Effective Lens Position Completed NCT01598428
21 Viscoat Versus Visthesia. A Comparative Study of Post-cataract Endothelial Cell Loss Completed NCT02304861
22 Aqualase Versus Torsional ip. A Study on Endothelial Cells, Corneal Edema and Corneal Sensitivity Completed NCT01480557
23 Clinical Analysis of Ocular Parameters Contributing to Intraoperative Pain During Standard Phacoemulsification Completed NCT03031652
24 Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System Completed NCT00078299
25 How Astigmatism Influences Corneal Biomechanics and Intraocular Pressure Completed NCT03162471
26 A Pilot Study Simulating Multifocal Intraocular Lenses in Healthy Subjects Completed NCT01873781 Cyclopentolatehydrochloride
27 Comparison of the Effect of Hydrophobic Acrylic and Silicone 3-piece IOLs on Posterior Capsule Opacification Completed NCT01936701
28 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two IOLs: Hoya iMics Y-60H vs. Bausch&Lomb MI60 (MIMI) Completed NCT01786356
29 Posterior Capsule Opacification Development With Two Different Intraocular Lenses Completed NCT01734343
30 Patient Participation in Free Cataract Surgery Completed NCT02633865
31 A Pilot Study Investigating the Impact of Different IOL Designs on Subjective 2D and 3D Image Quality Completed NCT02409641 Cyclopentolatehydrochloride 0,5% eye drops
32 Performance of a Single-piece Toric Acrylic Intraocular Lens Completed NCT02155959
33 Rotation of an Intraocular Lens - HOYA Vivinex iSert P261 Completed NCT03157375
34 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two Microincision IOLs: Hoya iMics NY-60 vs Acrysof SN60WF Completed NCT01732484
35 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two Microincision IOLs: Tecnis ZCB00 and Acrysof SA60AT Completed NCT01742910
36 Comparison of In-the-bag Stability Between Single-piece and Three-piece Intraocular Lens Completed NCT02609997 Subconjunctival dexamethasone;proparacaine
37 Dynamic Light Scattering for Studying Lens Aging and Cataract Formation Completed NCT00081991
38 Long-term Evaluation of Single-piece ACrysof IOL Implantation on Development of Posterior Capsule Opacification Completed NCT01820065
39 Comparison of Manual Super Small Incision Cataract Surgery and Phacoemulsification Completed NCT01146964
40 Evaluation of Posterior Capsule Opacification in Eyes With Diabetes Mellitus Completed NCT01480934
41 Dysfunctional Lens Index Serves as a Novel Surgery Decision Maker for Age-related Cataracts Recruiting NCT03340389
42 Precisight® Intraocular Lens Implantation for Cataract Treatment Recruiting NCT02970487
43 Shanghai High Myopia Study Recruiting NCT03062085
44 Two Different Cataract Surgical Procedures to Prevent Posterior Capsule Opacification Recruiting NCT02445274
45 Neural Compensation, Visual Function and Visual Quality After Monofocal or Multifocal Intraocular Lens Implantation Recruiting NCT02644720 Dexamethasone
46 Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL Recruiting NCT02817191 Hylo-Comod eye drop;Tears Naturale Forte eye drop
47 Aqueous Urea Concentration May be Related to Cataract Development Recruiting NCT03324295
48 Patient Registry of Posner-Schlossman Syndrome Recruiting NCT03233477
49 Safety and Efficacy of Implantation of Two Multifocal Intraocular Lenses in the Treatment of Senile Cataract Active, not recruiting NCT02966496
50 Changes in Prostaglandin Levels in Laser Cataract Surgery (LCS) Subject to Laser Prevalence Active, not recruiting NCT03390400

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

Anatomical Context for Senile Cataract

MalaCards organs/tissues related to Senile Cataract:

38
Eye, Endothelial, Testes, Retina, Cortex, Skin

Publications for Senile Cataract

Articles related to Senile Cataract:

(show top 50) (show all 266)
# Title Authors Year
1
Association of angiotensin-converting enzyme, CYP46A1 genes polymorphism with senile cataract. ( 28298860 )
2017
2
Comment on: Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. ( 28345577 )
2017
3
Comparison of visual performance and after cataract formation between two monofocal aspheric intraocular lenses following phacoemulsification for senile cataract: A randomized controlled study. ( 29208832 )
2017
4
Comment on: Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. ( 28345578 )
2017
5
Study of association between pre-senile cataracts and rs11615 of ERCC1, rs13181 of ERCC2, and rs25487 of XRCC1 polymorphisms in a Spanish population. ( 27668351 )
2017
6
Genetic testing of individuals with pre-senile cataract identifies patients with myotonic dystrophy type 2. ( 29024355 )
2017
7
Comparison of the mechanical properties of the anterior lens capsule in senile cataract, senile cataract with trypan blue application, and pseudoexfoliation syndrome. ( 28917406 )
2017
8
The Incidence of Senile Cataract and Glaucoma is Increased in Patients with Plasma Cell Dyscrasias: Etiologic Implications. ( 27328652 )
2016
9
The Predictability of Preoperative Pilocarpine-Induced Lens Shift on the Outcomes of Accommodating Intraocular Lenses Implanted in Senile Cataract Patients. ( 27516899 )
2016
10
Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. ( 27703255 )
2016
11
Prevalence of Pseudoexfoliation Syndrome in Turkish Patients with Senile Cataract. ( 26795697 )
2016
12
Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population. ( 27248495 )
2016
13
Analytical and physicochemical characterisation of the senile cataract drug dipeptide I^-alanyl-L-histidine (carnosine). ( 26073114 )
2015
14
Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1. ( 26884880 )
2015
15
Comparison of preoperative nepafenac (0.1%) and flurbiprofen (0.03%) eye drops in maintaining mydriasis during small incision cataract surgery in patients with senile cataract: A randomized, double-blind study. ( 26600636 )
2015
16
Characteristics of the Anterior Segment Biometry and Corneal Endothelium in Eyes with Pseudoexfoliation Syndrome and Senile Cataract. ( 27800230 )
2015
17
Serum free Fatty acids level in senile cataract. ( 25079310 )
2014
18
Cost-of-Illness Study of Senile Cataract in the Czech Republic. ( 27202109 )
2014
19
Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients. ( 23142692 )
2013
20
Primary posterior capsular opacification in Indian rural population undergoing cataract surgery for hypermature senile cataract. ( 23966767 )
2013
21
Sequelae of neglected senile cataract. ( 25606266 )
2013
22
Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. ( 23552357 )
2013
23
Common genetic link between metabolic syndrome components and senile cataract. ( 22165987 )
2012
24
C1824T mutation in the LMNA gene has no association with senile cataract. ( 22079058 )
2012
25
Idiopathic phacodonesis in senile cataract patients in Qinghai, China. ( 22553712 )
2011
26
Quantitative assessment of DNA damage directly in lens epithelial cells from senile cataract patients. ( 21224996 )
2011
27
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. ( 22360021 )
2011
28
Association of glutathione S-transferases polymorphisms (GSTM1 and GSTT1) with senile cataract: a meta-analysis. ( 20574021 )
2010
29
Difference in redox status of serum and aqueous humor in senile cataract patients as monitored via the albumin thiol-redox state. ( 21191720 )
2010
30
Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. ( 20808731 )
2010
31
Phospholipid and protein contents of lens proteolipids in human senile cataract. ( 19590524 )
2010
32
Characteristics of the corneal endothelium and pseudoexfoliation syndrome in patients with senile cataract. ( 20456430 )
2010
33
Comparative study of plasma ascorbic acid levels in senile cataract patients and in normal individuals. ( 19219683 )
2009
34
Synergistic effects of metal ion and the pre-senile cataract-causing G98R alphaA-crystallin: self-aggregation propensities and chaperone activity. ( 19862354 )
2009
35
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. ( 18982249 )
2009
36
Oxidative stress markers in aqueous humor of patients with senile cataracts. ( 19172468 )
2009
37
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and senile cataract in a Sardinian male population, Italy. ( 19995205 )
2009
38
Implication of glutathione S-transferase M1 and T1 polymorphisms in the development of senile cataract among Egyptians. ( 20120433 )
2009
39
Systemic redox modifications in senile cataract. ( 20446444 )
2009
40
Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. ( 19093039 )
2008
41
Plasma Homocysteine, Folate and Vitamin B(12) levels in senile cataract. ( 23105765 )
2008
42
Plasma redox status and premature onset of senile cataract. ( 17966444 )
2007
43
Evaluation of serum zinc level and plasma SOD activity in senile cataract patients under oxidative stress. ( 23105695 )
2007
44
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. ( 16581614 )
2006
45
Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk. ( 16551760 )
2006
46
Strabismus in senile cataract patients. ( 16213390 )
2005
47
Comparative analysis of the eye function and complications after removal of complicated cataract due to uveitis and senile cataract. ( 16416988 )
2005
48
Outcomes of cataract surgery in senile cataract patients at Siriraj Hospital: a prospective observational study. ( 16681057 )
2005
49
Sensory exotropia subsequent to senile cataract. ( 16358383 )
2005
50
Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract. ( 15105821 )
2005

Variations for Senile Cataract

Expression for Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for Senile Cataract

GO Terms for Senile Cataract

Cellular components related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.23 ALB CRYAA G6PD GSR GSTT1 SERPINF1

Biological processes related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retina homeostasis GO:0001895 9.37 ALB SOD1
2 cellular response to oxidative stress GO:0034599 9.33 G6PD GSR SOD1
3 glutathione derivative biosynthetic process GO:1901687 9.32 GSTM1 GSTT1
4 pentose-phosphate shunt GO:0006098 9.26 G6PD TALDO1
5 cellular oxidant detoxification GO:0098869 9.13 ALB GSR GSTT1
6 glutathione metabolic process GO:0006749 9.02 G6PD GSR GSTM1 GSTT1 SOD1

Molecular functions related to Senile Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.32 ALB SOD1
2 NADP binding GO:0050661 9.26 G6PD GSR
3 glutathione transferase activity GO:0004364 9.16 GSTM1 GSTT1
4 antioxidant activity GO:0016209 8.96 ALB SOD1
5 structural constituent of eye lens GO:0005212 8.62 BFSP1 CRYAA

Sources for Senile Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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