MCID: SNL007
MIFTS: 43

Senile Cataract malady

Eye diseases category
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Summaries for Senile Cataract

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33MalaCards
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MalaCards: Senile Cataract is related to cataract and open-angle glaucoma. An important gene associated with Senile Cataract is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Sulfation Biotransformation Reaction and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds o-ethylhydroxylamine and no-dimethylhydroxylamine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Aliases & Classifications for Senile Cataract

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 58SNOMED-CT, 62UMLS, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

senile cataract 8 10 45


External Ids:

Disease Ontology8 DOID:9669
ICD9CM27 366.10, 366.1
NCIt40 C35012
ICD1025 H25

Related Diseases for Senile Cataract

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17GeneCards, 18GeneDecks
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Diseases related to Senile Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1cataract31.8SERPINF1, G6PD, GSR, GSTT1
2open-angle glaucoma30.5GSTM1, GSTT1
3glaucoma10.5
4immature cataract10.3
5cortical senile cataract10.3
6nuclear senile cataract10.3
7primary open angle glaucoma10.2
8diabetes mellitus10.2
9diabetic retinopathy10.2
10iritis10.1
11glucose intolerance10.1
12mature cataract10.1
13keratomalacia10.1
14corneal dystrophy10.1
15exotropia10.1
16hypertension10.1
17myopia10.1
18obesity10.1
19refractive error10.1
20scleroderma10.1
21strabismus10.1
22uveitis10.1
23blindness10.1
24toxic encephalopathy10.1GSR
25diabetic cataract10.1GSR, G6PD
26glucosephosphate dehydrogenase deficiency10.1G6PD, GSR
27methemoglobinemia10.0G6PD, GSR
28beta thalassemia10.0G6PD, GSR
29plasmodium falciparum malaria10.0GSR, G6PD
30vitiligo10.0GSR, G6PD
31schistosomiasis10.0GSTM1, GSR
32brain cancer10.0GSTT1, GSTM1
33asbestosis10.0GSTT1, GSTM1
34acute myeloid leukemia, adult10.0GSTT1, GSTM1
35leukoplakia10.0GSTM1, GSTT1
36aplastic anemia10.0GSTM1, GSTT1
37coronary artery disease10.0GSR, GSTT1
38primary hyperoxaluria10.0GSR, G6PD
39laryngeal squamous cell carcinoma10.0GSTM1, GSTT1
40acute lymphoblastic leukemia, childhood10.0GSTM1, GSTT1
41bladder carcinoma10.0GSTM1, GSTT1
42basal cell carcinoma10.0GSTT1, GSTM1
43oral cancer10.0GSTT1, GSTM1
44nasopharynx carcinoma10.0GSTM1, GSTT1
45acute myocardial infarction10.0GSTM1, GSR
46transitional cell carcinoma10.0GSTM1, GSTT1
47thyroid cancer10.0GSTT1, GSTM1
48gastric adenocarcinoma10.0GSTT1, GSTM1
49atherosclerosis10.0GSTT1, G6PD, SERPINF1
50myelodysplastic syndromes10.0GSTM1, GSTT1

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to senile cataract

Symptoms for Senile Cataract

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Drugs & Therapeutics for Senile Cataract

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Senile Cataract

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

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Anatomical Context for Senile Cataract

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33MalaCards
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MalaCards organs/tissues related to Senile Cataract:

33
Eye, Testes, Cortex, Retina, Skin

Animal Models for Senile Cataract or affiliated genes

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Publications for Senile Cataract

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Sources:
52PubMed
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Articles related to Senile Cataract:

(show top 50)    (show all 245)
idTitleAuthorsYear
1
Primary posterior capsular opacification in Indian rural population undergoing cataract surgery for hypermature senile cataract. (23966767)
2013
2
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. (22360021)
2011
3
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. (18982249)
2009
4
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. (16581614)
2006
5
Strabismus in senile cataract patients. (16213390)
2005
6
Outcomes of cataract surgery in senile cataract patients at Siriraj Hospital: a prospective observational study. (16681057)
2005
7
The study on superoxide dismutase and trace element in patients with senile cataract]. (12579780)
2000
8
Change of water-soluble-protein, urea-soluble-protein and membrane intrinsic protein in human senile cataract. (8758837)
1995
9
Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients. (8595250)
1995
10
Lens epithelium in senile cataract. (7912592)
1994
11
Galactokinase activity in patients with idiopathic presenile and senile cataract. (1305705)
1992
12
Senile cataract-related accumulation of Lewis(x) glycolipid in human lens. (1348055)
1992
13
Senile cataract: a review on free radical related pathogenesis and antioxidant prevention. (15374435)
1991
14
Oxygen and light as risk factors in senile cataract development: experimental studies. (1868942)
1991
15
H2O2-dependent NADH oxidation activity in senile cataractous human lens: its relation to glutathione redox cycle. (2214362)
1990
16
Increase in lens gangliosides due to aging and cataract progression in human senile cataract. (2211013)
1990
17
Nucleotide levels in human lens: regional distribution in different forms of senile cataract. (2920783)
1989
18
Senile cataract and vitamin nutrition. (2601897)
1989
19
Senile cataract: survey on cataract patients undergoing cataract surgery, Japan. (2792527)
1989
20
Amino acid concentrations in serum and aqueous humor from subjects with extreme myopia or senile cataract. (3402067)
1988
21
Idiopathic presenile and senile cataract formation and changes in lactase activity. (3125097)
1987
22
The Emory mouse cataract: an animal model for human senile cataract. (7346236)
1981-1982
23
Senile cataract and plasma tryptophan. (6115288)
1981
24
Plasma tryptophan in senile cataract. (6102340)
1980
25
Human senile cataract and Na-K ATP'ase activity in the anterior lens structures with special reference to anterior capsular/subcapsular opacity. (6259880)
1980
26
Cholesterol and phospholipids in protein fractions of human lens and senile cataract. (667096)
1978
27
Distribution of glycolytic enzymes in nuclear and peripheral lens secretions of the human senile cataract. (891511)
1977
28
Senile cataract extraction and diabetes. (1276117)
1976
29
Proteolipids and phosphatido-peptides in senile cataract. (4660295)
1972
30
Lipoproteins of the crystalline lens and serum factors in senile cataract. (5161574)
1971
31
Protein metabolism in human senile cataract. (5130524)
1971
32
Senile cataract: serum factor producing irreversible precipitation of a lens protein. (5786890)
1969
33
Senile cataract. (4175685)
1968
34
Complication at the posterior pole of the eye after senile cataract intracapsular extraction. (5698655)
1968
35
Quantitative study of the variations in the levels of glutathione and ascorbic acid in human lenses with senile cataract. (5728733)
1968
36
Modifications of adenosine triphosphate and of some enzymatic activities during the development of human senile cataract. (6024065)
1967
37
Further studies on ribonucleic acid content and distribution during the development of senile cataract. (6019482)
1967
38
On the significance of the phacoautoantibodies demonstrated in the sera of patients with senile cataract. (6020397)
1967
39
CRYOXTRACTION OF LENS IN SENILE CATARACT SURGERY. (14263323)
1965
40
On the changes in the activity of glutathione reductase on the maturation of senile cataract. (13751487)
1961
41
Biochemical studies on cataract. V. Biochemical genesis of senile cataract. (13411160)
1957
42
Senile cataract; a geriatric problem. (13003680)
1952
43
The senile cataract patient; a pattern for surgical management. (18112879)
1949
44
Comparison of results in a series of senile cataract extractions using three techniques. (18121654)
1948
45
Vitamin C saturation and senile cataract. (21004334)
1945
46
Fuchs's corneal dystrophy complicated by senile cataract. (21065532)
1945
47
Senile Cataract. (20476150)
1938
48
Progress of Senile Cataract under Hygienic Care. (16692694)
1924
49
A study of the nativity, sex, age, occupation, and social condition of 3,436 cases of senile cataract operated upon at the Wills Hospital in Philadelphia. (16692073)
1906
50
On the Extraction of Senile Cataract in its Capsule. (20750458)
1883

Variations for Senile Cataract

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Expression for genes affiliated with Senile Cataract

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for genes affiliated with Senile Cataract

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Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG, 60Thomson Reuters, 55Reactome
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Pathways related to Senile Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5G6PD, GSR
29.0GSTM1, GSTT1
3
Show member pathways
9.0GSTT1, GSTM1
49.0GSTT1, GSTM1
5
Show member pathways
8.5GSTT1, GSTM1, GSR
6
Show member pathways
glutathione-mediated detoxification I38
glutathione redox reactions I38
glutathione redox reactions II38
4-hydroxy-2-nonenal detoxification38
Glutathione metabolism60
Glutathione metabolism38
8.1GSTT1, GSTM1, GSR, G6PD
7
Show member pathways
8.1GSTT1, GSTM1, GSR, G6PD

Compounds for genes affiliated with Senile Cataract

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience
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Compounds related to Senile Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1o-ethylhydroxylamine459.9GSR, G6PD
2no-dimethylhydroxylamine459.9G6PD, GSR
32,5-adp459.8GSR, G6PD
4thiobarbituric acid459.7G6PD, GSR
5n-(2-hydroxyethyl)valine459.4GSTT1, GSTM1
6drugs for treatment of tuberculosis519.4GSTT1, GSTM1
7methylchloride459.4GSTM1, GSTT1
8trans,trans-muconic acid459.4GSTT1, GSTM1
9ethambutol51 4510.4GSTT1, GSTM1
10s-phenylmercapturic acid459.4GSTM1, GSTT1
11ethylene oxide459.4GSTT1, GSTM1
12glutathion459.4GSTM1, GSR
13styrene oxide459.4GSTM1, GSTT1
142-naphthol459.4GSTM1, GSTT1
15hema459.4GSTM1, GSTT1
16butadiene monoxide459.3GSTT1, GSTM1
171,3-butadiene459.3GSTT1, GSTM1
18vinylchloride459.3GSTM1, GSTT1
19streptomycin51 45 1111.3GSTM1, GSTT1
20pyrazinamide45 51 1111.3GSTT1, GSTM1
21arylamine459.3GSTM1, GSTT1
22vitamin-e459.2GSTT1, G6PD, GSR
23diepoxybutane459.2GSTT1, GSTM1
241-hydroxypyrene459.1GSTT1, GSTM1
25gssg459.1GSTM1, GSR, G6PD
26trimethoprim51 45 1111.1G6PD, GSTM1
27styrene459.1GSTT1, GSTM1
284-hydroxynonenal45 2410.1GSTM1, GSR, G6PD
29toluene459.0GSTT1, GSTM1
30trichloroethylene459.0GSTT1, GSTM1
31alpha tocopherol459.0GSTM1, GSR, G6PD
32isoniazid45 51 1111.0GSTT1, G6PD, GSTM1
33gsts458.9GSR, GSTT1, GSTM1
34Glutathione24 119.9GSR, GSTM1, GSTT1
35manganese superoxide458.9GSTM1, GSTT1, GSR
36carboplatin45 51 1110.9GSTM1, GSTT1, GSR
37nadph45 249.8SERPINF1, GSR, GSTT1, G6PD
38valine458.8GSTT1, GSTM1, G6PD
39cumene hydroperoxide458.5GSR, G6PD, GSTT1, GSTM1
40h2o2458.5G6PD, SERPINF1, GSTM1, GSR
41acetone458.5GSTM1, GSR, G6PD, GSTT1
42malondialdehyde458.5G6PD, GSR, GSTM1, GSTT1
43cyclophosphamide45 51 1110.5GSTT1, GSTM1, GSR, G6PD
44folate458.5G6PD, GSR, GSTM1, GSTT1
45ascorbic acid45 249.5GSTM1, GSTT1, GSR, G6PD
46doxorubicin45 51 1110.5G6PD, GSTT1, GSTM1, GSR
47cisplatin45 51 61 1111.5GSTT1, GSTM1, GSR, G6PD
48creatinine458.4G6PD, GSTM1, GSR, GSTT1
49oxygen45 249.0GSTT1, SERPINF1, G6PD, GSR, GSTM1
50estrogen457.8G6PD, GSTM1, GSTT1, GSR

GO Terms for genes affiliated with Senile Cataract

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16Gene Ontology
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Cellular components related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.1GSTT1, GSTM1, GSR, G6PD

Biological processes related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to organic cyclic compoundGO:0140709.3GSTT1, G6PD
2oxidation-reduction processGO:0551149.1GSTT1, G6PD
3glutathione derivative biosynthetic processGO:19016879.1GSTT1, GSTM1
4xenobiotic metabolic processGO:0068059.0GSTT1, GSTM1
5glutathione metabolic processGO:0067498.2GSTT1, GSTM1, GSR, G6PD
6small molecule metabolic processGO:0442818.1G6PD, GSR, GSTM1, GSTT1

Molecular functions related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.5GSR, G6PD
2glutathione transferase activityGO:0043648.7GSTT1, GSTM1

Products for genes affiliated with Senile Cataract

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Senile Cataract

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet