MCID: SNL007
MIFTS: 46

Senile Cataract malady

Eye diseases category

Summaries for Senile Cataract

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Senile Cataract is related to cataract and diabetic cataract. An important gene associated with Senile Cataract is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Aflatoxin B1 metabolism and Pentose phosphate pathway (hexose monophosphate shunt). The compounds gssg and nadph have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin, and related mouse phenotype vision/eye.

Aliases & Classifications for Senile Cataract

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 56SNOMED-CT, 60UMLS, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

senile cataract 8 10 44


External Ids:

Disease Ontology8 DOID:9669
ICD9CM27 366.10, 366.1
NCIt39 C35012
ICD1025 H25

Related Diseases for Senile Cataract

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to senile cataract

Clinical Features for Senile Cataract

About this section

Drugs & Therapeutics for Senile Cataract

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Senile Cataract

Drug clinical trials:

Search ClinicalTrials for Senile Cataract

Search NIH Clinical Center for Senile Cataract

Search CenterWatch for Senile Cataract

Genetic Tests for Senile Cataract

About this section

Anatomical Context for Senile Cataract

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Senile Cataract:

32
Eye, Testes, Skin, Retina, Cortex

Animal Models for Senile Cataract or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Senile Cataract:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.6GSR, SOD1, GALK1, CRYBB2, CRYAA, CRYGS

Publications for Senile Cataract

About this section
Sources:
50PubMed
See all sources

Articles related to Senile Cataract:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
Primary posterior capsular opacification in Indian rural population undergoing cataract surgery for hypermature senile cataract. (23966767)
2013
2
Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. (23552357)
2013
3
Glutathione S-transferases polymorphisms confer susceptibility to senile cortical cataract in the Han Chinese population. (22665971)
2012
4
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. (22360021)
2011
5
Difference in redox status of serum and aqueous humor in senile cataract patients as monitored via the albumin thiol-redox state. (21191720)
2010
6
Characteristics of the corneal endothelium and pseudoexfoliation syndrome in patients with senile cataract. (20456430)
2010
7
Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. (20808731)
2010
8
Systemic redox modifications in senile cataract. (20446444)
2009
9
Evaluation of serum zinc level and plasma SOD activity in senile cataract patients under oxidative stress. (23105695)
2007
10
Strabismus in senile cataract patients. (16213390)
2005
11
Changes in glutathione, glutathione-linked enzymes and hexose monophosphate shunt enzymes in senile cataract. (15255623)
2003
12
Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. (10892871)
2000
13
Sensory deviations subsequent to senile cataract. (10845417)
2000
14
Expression of transforming growth factor (TGF)-alpha, TGF-beta(2) and interleukin 8 messenger RNA in postsurgical and cultured lens epithelial cells obtained from patients with senile cataracts. (10502054)
1999
15
A rural population based case-control study of senile cataract in India. (10616266)
1999
16
Morphological and morphometrical study of human lens in senile cataract. (9230582)
1997
17
Role of lipid peroxidation in the pathogenesis of myopic and senile cataract. (8942384)
1996
18
Variation in the glycosidase activity of human lens during aging and with advance of senile cataract. (8593455)
1995
19
Galactokinase activity in patients with idiopathic presenile and senile cataract. (1305705)
1992
20
Senile cataract-related accumulation of Lewis(x) glycolipid in human lens. (1348055)
1992
21
Polishing the posterior capsule after extracapsular extraction of senile cataract. (1564657)
1992
22
The study of G6PD in erythrocyte and lens in senile and presenile cataract. (1286674)
1992
23
Increase in lens gangliosides due to aging and cataract progression in human senile cataract. (2211013)
1990
24
Clinical investigations on depigmentation of the pupillary border and translucency of the iris in cases of senile cataract and in normal eyes in elderly persons. (2541596)
1989
25
A note on the genetics of a unilateral senile cataract in mice. (2807646)
1989
26
Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels. (3389322)
1988
27
Indo-US case-control study of senile cataract--design and development. (3691930)
1987
28
Free amino acids composition of aqueous humor from Pakistani subjects with senile cataract. (3106668)
1987
29
Refractive error stress in the aetiology of senile cataract. (3443492)
1986
30
Senile cataract and senile macular degeneration: an investigation into possible risk factors. (3491448)
1986
31
Possible role of galactose-1-P-uridyl transferase activity deficiency in red blood cells in the development of the presenile and senile cataract. (3027641)
1986
32
Uncommon association--pre-senile cataract with scleroderma. (4044486)
1985
33
Alteration of serum tryptophan metabolism in patients suffering from senile cataract. (6521624)
1984-1985
34
Senile cataract and glucose intolerance: the Israel Study of glucose Intolerance Obesity and Hypertension (The Israel GOH Study). (6705665)
1984
35
A study of prevalence and risk factors of senile cataract in rural areas of western U.P. (6545318)
1984
36
An epidemiologic survey of senile cataract in China. (6819920)
1982
37
Tryptophan lens levels in senile cataract. (7082473)
1982
38
Senile cataract extraction and diabetes. (1276117)
1976
39
Studies on the early receptor potential in the human eye. IV. ERP in patients with senile cataract. (4466112)
1974
40
Long-term results of the Binkhorst iris clip lens in senile cataract. (5038717)
1972
41
Senile cataract: serum factors producing irreversible precipitation of a lens protein. (4982552)
1969
42
Complication at the posterior pole of the eye after senile cataract intracapsular extraction. (5698655)
1968
43
Quantitative study of the variations in the levels of glutathione and ascorbic acid in human lenses with senile cataract. (5728733)
1968
44
Modern treatment of senile cataract. (13012530)
1953
45
Malnutrition as an etiological factor in senile cataract. (14906345)
1952
46
What to tell the patient with early senile cataract. (14933712)
1952
47
Comparison of results in a series of senile cataract extractions using three techniques. (18121654)
1948
48
Intracapsular Extraction of Senile Cataract. (18743371)
1935
49
The rA'le of calcium in senile cataract. (16744293)
1929
50
Microscopic Findings in the Eyeball of a Man Who Died from an Untoward Cause Seven Weeks after the Extraction of a Senile Cataract. (16692270)
1912

Genetic Variations for Senile Cataract

About this section

Expression for genes affiliated with Senile Cataract

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for genes affiliated with Senile Cataract

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 29KEGG
See all sources

Compounds for genes affiliated with Senile Cataract

About this section
Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
See all sources

Compounds related to Senile Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1gssg4410.6G6PD, GSR
2nadph44 2411.5TALDO1, G6PD
3uric acid44 2411.5G6PD
4manganese superoxide4410.4CAT, GSR, GSTT1
5ionol4410.3SOD1, GSR, CAT
6oxygen44 2411.3SERPINF1, MIP, GSTM1
7propyl gallate4410.3GSR, CAT, SOD1
8guaiacol44 2411.3SOD1, GSR, CAT
9cumene hydroperoxide4410.3GSR, GSTM1, G6PD, GSTT1
103-amino-1,2,4-triazole4410.2CAT, GSR, SOD1
11isoniazid49 44 1112.2GSTM1, GSTT1, G6PD, CAT
12sodium azide4410.2G6PD, CAT, SOD1
13acetone4410.2GSTT1, GSR, G6PD, GSTM1
14thiobarbituric acid4410.2CAT, G6PD, SOD1, GSR
158-oxo-dg4410.2GSTM1, SOD1, GSTT1, CAT
16glutathion4410.2SOD1, CAT, GSR, GSTM1
17fructose-1,6-bisphosphate4410.2GSR, TALDO1, G6PD
18tocopherol4410.2CAT, SOD1, GSR, G6PD
19vitamin a44 11 2412.2CAT, TKT
20mannitol44 1111.2TALDO1, CAT, TKT
21ribose 5-phosphate4410.1TALDO1, TKT, G6PD
22butadiene monoxide4410.1GSTM1, TKT, GSTT1
23alpha lipoic acid4410.1GSR, CAT, G6PD, SOD1
24diphenyleneiodonium4410.1SERPINF1, G6PD, SOD1, CAT
25ebselen4410.1GSR, SOD1, CAT
26betacarotene4410.1GSTM1, GSR, SOD1, CAT
27dehydroascorbic acid44 1111.0SOD1, CAT, TALDO1, GSR, G6PD
284-hydroxynonenal44 2411.0GSTM1, SOD1, G6PD, CAT, GSR
29vitamin-e4410.0CAT, G6PD, SOD1, GSR, GSTT1
30carboplatin44 49 1112.0SOD1, GSTT1, GSR, GSTM1
31benzidine4410.0TKT, GSTT1, GSTM1
32alpha tocopherol4410.0GSR, GSTM1, SOD1, CAT, G6PD
336-phosphogluconate4410.0GSR, G6PD, TALDO1, TKT
34adrenochrome44 2411.0GSTT1, GSTM1, SOD1
35diethyl dithiocarbamate449.9GSR, SOD1, CAT, TKT
36hypoxanthine44 11 2411.9TKT, G6PD, SOD1, CAT
37malondialdehyde449.9G6PD, SOD1, CAT, GSTT1, GSTM1, GSR
38valine449.8GSTM1, GSTT1, GJA8, CRYAA, G6PD
39benzene449.8GSTT1, GSTM1, WRN
40glucose 6-phosphate44 2410.8CAT, TKT, TALDO1, G6PD, SOD1
418-oxoguanine449.7WRN, GSTT1, GSTM1
42h2o2449.7TALDO1, SERPINF1, MIP, WRN, CAT, G6PD
43carbon449.5MIP, TALDO1, TKT, FUCA1, G6PD
44creatinine449.3GSR, GSTM1, TKT, G6PD, SOD1, GSTT1
45n acetylcysteine449.3SERPINF1, G6PD, SOD1, CAT, GSR
46ascorbic acid44 2410.3GSTM1, GSTT1, TALDO1, G6PD, SOD1, CAT
47cisplatin44 49 59 1112.3GSTT1, GSR, GSTM1, TKT, G6PD, WRN
48arginine449.1WRN, SOD1, MIP, GSTT1, GSTM1, GSR
49lactate449.0MIP, SOD1, CAT, TKT, G6PD, TALDO1
50cysteine448.8SOD1, MIP, GSTM1, WRN, CRYAA, SERPINF1

GO Terms for genes affiliated with Senile Cataract

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.7CAT, SOD1, TKT
2cytosolGO:0058298.4CAT, SOD1, G6PD, GALK1, TALDO1, TKT

Biological processes related to Senile Cataract according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.9G6PD, TALDO1, TKT
2xylulose biosynthetic processGO:0059999.8TKT, TALDO1
3glutathione metabolic processGO:0067499.8GSTT1, GSR, GSTM1, G6PD, SOD1
4lens development in camera-type eyeGO:0020889.8CRYGS, MIP, GJA8
5carbohydrate metabolic processGO:0059759.6TKT, TALDO1, GALK1, G6PD
6visual perceptionGO:0076019.3GJA8, MIP, CRYAA, CRYBB1, CRYBB2
7small molecule metabolic processGO:0442818.6CAT, G6PD, GALK1, TALDO1, TKT, GSTM1

Molecular functions related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.0GSR, G6PD, CAT
2structural constituent of eye lensGO:0052128.9MIP, CRYGS, CRYAA, CRYBB1, CRYBB2, BFSP1
3protein homodimerization activityGO:0428038.5CAT, SOD1, G6PD, CRYBB2, WRN, TKT

Products for genes affiliated with Senile Cataract

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Senile Cataract

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet