MCID: SNL007
MIFTS: 43

Senile Cataract malady

Eye diseases category
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Summaries for Senile Cataract

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MalaCards based summary: Senile Cataract is related to cataract and open-angle glaucoma. An important gene associated with Senile Cataract is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Sulfation Biotransformation Reaction and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds o-ethylhydroxylamine and no-dimethylhydroxylamine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina.

Aliases & Classifications for Senile Cataract

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 57SNOMED-CT, 39NCIt, 62UMLS, 25ICD10
See all sources

Senile Cataract, Aliases & Descriptions:

Name: Senile Cataract 8 10 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:9669
ICD9CM27 366.10, 366.1
NCIt39 C35012
ICD1025 H25

Related Diseases for Senile Cataract

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Diseases related to Senile Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1cataract31.6G6PD, GSR, GSTT1, SERPINF1
2open-angle glaucoma30.5GSTT1, GSTM1
3toxic encephalopathy10.4GSR
4cortical senile cataract10.3
5nuclear senile cataract10.3
6immature cataract10.3
7diabetes mellitus10.3
8diabetic retinopathy10.3
9primary open angle glaucoma10.3
10diabetic cataract10.2G6PD, GSR
11glucosephosphate dehydrogenase deficiency10.2GSR, G6PD
12methemoglobinemia10.2GSR, G6PD
13beta thalassemia10.2G6PD, GSR
14plasmodium falciparum malaria10.2G6PD, GSR
15vitiligo10.2G6PD, GSR
16hypertension10.1
17obesity10.1
18iritis10.1
19mature cataract10.1
20glucose intolerance10.1
21keratomalacia10.1
22corneal dystrophy10.1
23exotropia10.1
24myopia10.1
25refractive error10.1
26scleroderma10.1
27strabismus10.1
28uveitis10.1
29blindness10.1
30schistosomiasis10.0GSTM1, GSR
31brain cancer10.0GSTM1, GSTT1
32asbestosis10.0GSTT1, GSTM1
33acute myeloid leukemia, adult10.0GSTT1, GSTM1
34leukoplakia10.0GSTM1, GSTT1
35aplastic anemia10.0GSTT1, GSTM1
36coronary artery anomaly10.0GSR, GSTT1
37primary hyperoxaluria10.0G6PD, GSR
38laryngeal squamous cell carcinoma10.0GSTT1, GSTM1
39acute lymphoblastic leukemia, childhood10.0GSTM1, GSTT1
40bladder carcinoma10.0GSTM1, GSTT1
41basal cell carcinoma10.0GSTT1, GSTM1
42oral cancer10.0GSTT1, GSTM1
43nasopharynx carcinoma10.0GSTT1, GSTM1
44acute myocardial infarction10.0GSTM1, GSR
45transitional cell carcinoma10.0GSTT1, GSTM1
46thyroid hurthle cell carcinoma9.9GSTM1, GSTT1
47gastric adenocarcinoma9.9GSTM1, GSTT1
48atherosclerosis9.9GSTT1, SERPINF1, G6PD
49myelodysplastic syndromes9.9GSTM1, GSTT1
50endometriosis9.9GSTT1, GSTM1

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to senile cataract

Symptoms for Senile Cataract

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Drugs & Therapeutics for Senile Cataract

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Drug clinical trials:

Search ClinicalTrials for Senile Cataract

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

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Anatomical Context for Senile Cataract

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MalaCards organs/tissues related to Senile Cataract:

32
Eye, Testes, Retina, Skin

Animal Models for Senile Cataract or affiliated genes

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Publications for Senile Cataract

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Articles related to Senile Cataract:

(show top 50)    (show all 246)
idTitleAuthorsYear
1
Primary posterior capsular opacification in Indian rural population undergoing cataract surgery for hypermature senile cataract. (23966767)
2013
2
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. (22360021)
2011
3
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. (18982249)
2009
4
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. (16581614)
2006
5
Strabismus in senile cataract patients. (16213390)
2005
6
Outcomes of cataract surgery in senile cataract patients at Siriraj Hospital: a prospective observational study. (16681057)
2005
7
The study on superoxide dismutase and trace element in patients with senile cataract]. (12579780)
2000
8
Change of water-soluble-protein, urea-soluble-protein and membrane intrinsic protein in human senile cataract. (8758837)
1995
9
Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients. (8595250)
1995
10
Lens epithelium in senile cataract. (7912592)
1994
11
Galactokinase activity in patients with idiopathic presenile and senile cataract. (1305705)
1992
12
Senile cataract-related accumulation of Lewis(x) glycolipid in human lens. (1348055)
1992
13
Senile cataract: a review on free radical related pathogenesis and antioxidant prevention. (15374435)
1991
14
Oxygen and light as risk factors in senile cataract development: experimental studies. (1868942)
1991
15
H2O2-dependent NADH oxidation activity in senile cataractous human lens: its relation to glutathione redox cycle. (2214362)
1990
16
Increase in lens gangliosides due to aging and cataract progression in human senile cataract. (2211013)
1990
17
Nucleotide levels in human lens: regional distribution in different forms of senile cataract. (2920783)
1989
18
Senile cataract and vitamin nutrition. (2601897)
1989
19
Senile cataract: survey on cataract patients undergoing cataract surgery, Japan. (2792527)
1989
20
Amino acid concentrations in serum and aqueous humor from subjects with extreme myopia or senile cataract. (3402067)
1988
21
Idiopathic presenile and senile cataract formation and changes in lactase activity. (3125097)
1987
22
The Emory mouse cataract: an animal model for human senile cataract. (7346236)
1981-1982
23
Senile cataract and plasma tryptophan. (6115288)
1981
24
Plasma tryptophan in senile cataract. (6102340)
1980
25
Human senile cataract and Na-K ATP'ase activity in the anterior lens structures with special reference to anterior capsular/subcapsular opacity. (6259880)
1980
26
Cholesterol and phospholipids in protein fractions of human lens and senile cataract. (667096)
1978
27
Distribution of glycolytic enzymes in nuclear and peripheral lens secretions of the human senile cataract. (891511)
1977
28
Senile cataract extraction and diabetes. (1276117)
1976
29
Proteolipids and phosphatido-peptides in senile cataract. (4660295)
1972
30
Lipoproteins of the crystalline lens and serum factors in senile cataract. (5161574)
1971
31
Protein metabolism in human senile cataract. (5130524)
1971
32
Senile cataract: serum factor producing irreversible precipitation of a lens protein. (5786890)
1969
33
Senile cataract. (4175685)
1968
34
Complication at the posterior pole of the eye after senile cataract intracapsular extraction. (5698655)
1968
35
Quantitative study of the variations in the levels of glutathione and ascorbic acid in human lenses with senile cataract. (5728733)
1968
36
Modifications of adenosine triphosphate and of some enzymatic activities during the development of human senile cataract. (6024065)
1967
37
Further studies on ribonucleic acid content and distribution during the development of senile cataract. (6019482)
1967
38
On the significance of the phacoautoantibodies demonstrated in the sera of patients with senile cataract. (6020397)
1967
39
CRYOXTRACTION OF LENS IN SENILE CATARACT SURGERY. (14263323)
1965
40
On the changes in the activity of glutathione reductase on the maturation of senile cataract. (13751487)
1961
41
Biochemical studies on cataract. V. Biochemical genesis of senile cataract. (13411160)
1957
42
Senile cataract; a geriatric problem. (13003680)
1952
43
The senile cataract patient; a pattern for surgical management. (18112879)
1949
44
Comparison of results in a series of senile cataract extractions using three techniques. (18121654)
1948
45
Vitamin C saturation and senile cataract. (21004334)
1945
46
Fuchs's corneal dystrophy complicated by senile cataract. (21065532)
1945
47
Senile Cataract. (20476150)
1938
48
Progress of Senile Cataract under Hygienic Care. (16692694)
1924
49
A study of the nativity, sex, age, occupation, and social condition of 3,436 cases of senile cataract operated upon at the Wills Hospital in Philadelphia. (16692073)
1906
50
On the Extraction of Senile Cataract in its Capsule. (20750458)
1883

Variations for Senile Cataract

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Expression for genes affiliated with Senile Cataract

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Expression patterns in normal tissues for genes affiliated with Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for genes affiliated with Senile Cataract

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Pathways related to Senile Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5G6PD, GSR
29.0GSTM1, GSTT1
3
Show member pathways
9.0GSTT1, GSTM1
49.0GSTT1, GSTM1
5
Show member pathways
8.5GSTT1, GSTM1, GSR
6
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
8.1GSTT1, GSTM1, GSR, G6PD
7
Show member pathways
8.1GSTT1, GSTM1, GSR, G6PD

Compounds for genes affiliated with Senile Cataract

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Compounds related to Senile Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1o-ethylhydroxylamine449.9G6PD, GSR
2no-dimethylhydroxylamine449.9GSR, G6PD
32,5-adp449.8GSR, G6PD
4thiobarbituric acid449.7GSR, G6PD
5drugs for treatment of tuberculosis509.4GSTM1, GSTT1
6methylchloride449.4GSTM1, GSTT1
7n-(2-hydroxyethyl)valine449.4GSTM1, GSTT1
8trans,trans-muconic acid449.4GSTT1, GSTM1
9ethambutol50 4410.4GSTT1, GSTM1
10s-phenylmercapturic acid449.4GSTT1, GSTM1
11styrene oxide449.4GSTM1, GSTT1
12ethylene oxide449.4GSTM1, GSTT1
132-naphthol449.4GSTM1, GSTT1
14glutathion449.4GSTM1, GSR
15hema449.4GSTM1, GSTT1
16butadiene monoxide449.3GSTT1, GSTM1
171,3-butadiene449.3GSTM1, GSTT1
18vinylchloride449.3GSTT1, GSTM1
19streptomycin50 44 1111.3GSTM1, GSTT1
20pyrazinamide44 50 1111.3GSTM1, GSTT1
21vitamin-e449.2GSTT1, GSR, G6PD
22arylamine449.2GSTT1, GSTM1
23diepoxybutane449.2GSTT1, GSTM1
241-hydroxypyrene449.1GSTM1, GSTT1
25gssg449.1G6PD, GSR, GSTM1
26trimethoprim50 44 1111.1GSTM1, G6PD
27toluene449.1GSTM1, GSTT1
284-hydroxynonenal44 2410.1G6PD, GSR, GSTM1
29styrene449.0GSTM1, GSTT1
30trichloroethylene449.0GSTT1, GSTM1
31alpha tocopherol449.0G6PD, GSR, GSTM1
32isoniazid44 50 1111.0GSTT1, GSTM1, G6PD
33gsts448.9GSTT1, GSTM1, GSR
34Glutathione24 119.9GSR, GSTM1, GSTT1
35manganese superoxide448.9GSR, GSTM1, GSTT1
36carboplatin44 50 1110.9GSR, GSTM1, GSTT1
37nadph44 249.8GSTT1, GSR, G6PD, SERPINF1
38valine448.8G6PD, GSTM1, GSTT1
39cumene hydroperoxide448.5GSTT1, GSTM1, GSR, G6PD
40h2o2448.5GSTM1, GSR, G6PD, SERPINF1
41acetone448.5G6PD, GSR, GSTM1, GSTT1
42malondialdehyde448.5G6PD, GSR, GSTM1, GSTT1
43cyclophosphamide44 50 1110.5GSTT1, GSTM1, GSR, G6PD
44folate448.5G6PD, GSR, GSTM1, GSTT1
45ascorbic acid44 249.5G6PD, GSR, GSTM1, GSTT1
46doxorubicin44 50 1110.5G6PD, GSR, GSTM1, GSTT1
47cisplatin44 50 61 1111.5G6PD, GSR, GSTM1, GSTT1
48creatinine448.4GSTT1, GSTM1, GSR, G6PD
49oxygen44 249.0GSTT1, GSTM1, GSR, G6PD, SERPINF1
50estrogen447.8G6PD, GSR, GSTM1, GSTT1

GO Terms for genes affiliated with Senile Cataract

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Cellular components related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.1GSTT1, GSTM1, GSR, G6PD

Biological processes related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to organic cyclic compoundGO:0140709.3GSTT1, G6PD
2oxidation-reduction processGO:0551149.1GSTT1, G6PD
3glutathione derivative biosynthetic processGO:19016879.1GSTT1, GSTM1
4xenobiotic metabolic processGO:0068059.0GSTT1, GSTM1
5glutathione metabolic processGO:0067498.2GSTT1, GSTM1, GSR, G6PD
6small molecule metabolic processGO:0442818.1G6PD, GSR, GSTM1, GSTT1

Molecular functions related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.5GSR, G6PD
2glutathione transferase activityGO:0043648.7GSTT1, GSTM1

Products for genes affiliated with Senile Cataract

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  • Antibodies
  • Proteins
  • Lysates

Sources for Senile Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet