MCID: SNL007
MIFTS: 42

Senile Cataract malady

Eye diseases category

Summaries for Senile Cataract

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MalaCards based summary: Senile Cataract is related to cataract and open-angle glaucoma. An important gene associated with Senile Cataract is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Sulfation Biotransformation Reaction and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds o-ethylhydroxylamine and no-dimethylhydroxylamine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Aliases & Classifications for Senile Cataract

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 40NCIt, 57SNOMED-CT, 29ICD9CM, 62UMLS, 27ICD10
See all sources

Senile Cataract, Aliases & Descriptions:

Name: Senile Cataract 10 12 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology10 DOID:9669
NCIt40 C35012
ICD9CM29 366.1, 366.10
ICD1027 H25

Related Diseases for Senile Cataract

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Diseases related to Senile Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1cataract31.9SERPINF1, G6PD, GSR, GSTT1
2open-angle glaucoma30.5GSTM1, GSTT1
3immature cataract10.3
4cortical senile cataract10.3
5nuclear senile cataract10.3
6obesity10.1
7iritis10.1
8glucose intolerance10.1
9mature cataract10.1
10glucose-6-phosphate dehydrogenase deficiency10.1
11keratomalacia10.1
12corneal dystrophy10.1
13exotropia10.1
14myopia10.1
15refractive error10.1
16scleroderma10.1
17strabismus10.1
18uveitis10.1
19blindness10.1
20toxic encephalopathy10.0GSR
21diabetic cataract10.0GSR, G6PD
22glucosephosphate dehydrogenase deficiency10.0G6PD, GSR
23methemoglobinemia10.0G6PD, GSR
24thalassemia, hispanic gamma-delta-beta10.0G6PD, GSR
25plasmodium falciparum malaria10.0GSR, G6PD
26vitiligo-associated multiple autoimmune disease susceptibility 110.0GSR, G6PD
27alcohol dependence10.0GSR, G6PD
28schistosomiasis10.0GSTM1, GSR
29brain cancer10.0GSTT1, GSTM1
30asbestosis10.0GSTT1, GSTM1
31mismatch repair cancer syndrome10.0GSTM1, GSTT1
32acute myeloid leukemia, adult10.0GSTT1, GSTM1
33leukoplakia10.0GSTM1, GSTT1
34aplastic anemia10.0GSTM1, GSTT1
35laryngeal squamous cell carcinoma10.0GSTM1, GSTT1
36coronary artery disease10.0GSR, GSTT1
37primary hyperoxaluria10.0GSR, G6PD
38nicotine dependence, protection against10.0GSTM1, GSTT1
39acute lymphoblastic leukemia, childhood10.0GSTM1, GSTT1
40bladder cancer, somatic10.0GSTM1, GSTT1
41basal cell carcinoma10.0GSTT1, GSTM1
42oral cancer10.0GSTT1, GSTM1
43nasopharyngeal carcinoma10.0GSTM1, GSTT1
44acute myocardial infarction10.0GSTM1, GSR
45transitional cell carcinoma10.0GSTM1, GSTT1
46thyroid cancer10.0GSTT1, GSTM1
47gastric adenocarcinoma10.0GSTT1, GSTM1
48atherosclerosis10.0GSTT1, G6PD, SERPINF1
49myelodysplastic syndrome10.0GSTM1, GSTT1
50endometriosis10.0GSTT1, GSTM1

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to senile cataract

Symptoms for Senile Cataract

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Drugs & Therapeutics for Senile Cataract

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Drug clinical trials:

Search ClinicalTrials for Senile Cataract

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

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Anatomical Context for Senile Cataract

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MalaCards organs/tissues related to Senile Cataract:

33
Eye, Testes, Cortex, Retina, Skin

Animal Models for Senile Cataract or affiliated genes

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Publications for Senile Cataract

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Articles related to Senile Cataract:

(show top 50)    (show all 248)
idTitleAuthorsYear
1
Primary posterior capsular opacification in Indian rural population undergoing cataract surgery for hypermature senile cataract. (23966767)
2013
2
Sequelae of neglected senile cataract. (25606266)
2013
3
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. (22360021)
2011
4
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. (18982249)
2009
5
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. (16581614)
2006
6
Strabismus in senile cataract patients. (16213390)
2005
7
Outcomes of cataract surgery in senile cataract patients at Siriraj Hospital: a prospective observational study. (16681057)
2005
8
The study on superoxide dismutase and trace element in patients with senile cataract]. (12579780)
2000
9
Change of water-soluble-protein, urea-soluble-protein and membrane intrinsic protein in human senile cataract. (8758837)
1995
10
Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients. (8595250)
1995
11
Lens epithelium in senile cataract. (7912592)
1994
12
Galactokinase activity in patients with idiopathic presenile and senile cataract. (1305705)
1992
13
Senile cataract-related accumulation of Lewis(x) glycolipid in human lens. (1348055)
1992
14
Senile cataract: a review on free radical related pathogenesis and antioxidant prevention. (15374435)
1991
15
Oxygen and light as risk factors in senile cataract development: experimental studies. (1868942)
1991
16
H2O2-dependent NADH oxidation activity in senile cataractous human lens: its relation to glutathione redox cycle. (2214362)
1990
17
Increase in lens gangliosides due to aging and cataract progression in human senile cataract. (2211013)
1990
18
Nucleotide levels in human lens: regional distribution in different forms of senile cataract. (2920783)
1989
19
Senile cataract and vitamin nutrition. (2601897)
1989
20
Senile cataract: survey on cataract patients undergoing cataract surgery, Japan. (2792527)
1989
21
Amino acid concentrations in serum and aqueous humor from subjects with extreme myopia or senile cataract. (3402067)
1988
22
Idiopathic presenile and senile cataract formation and changes in lactase activity. (3125097)
1987
23
The Emory mouse cataract: an animal model for human senile cataract. (7346236)
1981-1982
24
Senile cataract and plasma tryptophan. (6115288)
1981
25
Plasma tryptophan in senile cataract. (6102340)
1980
26
Human senile cataract and Na-K ATP'ase activity in the anterior lens structures with special reference to anterior capsular/subcapsular opacity. (6259880)
1980
27
Cholesterol and phospholipids in protein fractions of human lens and senile cataract. (667096)
1978
28
Distribution of glycolytic enzymes in nuclear and peripheral lens secretions of the human senile cataract. (891511)
1977
29
Senile cataract extraction and diabetes. (1276117)
1976
30
Proteolipids and phosphatido-peptides in senile cataract. (4660295)
1972
31
Lipoproteins of the crystalline lens and serum factors in senile cataract. (5161574)
1971
32
Senile cataract: serum factor producing irreversible precipitation of a lens protein. (5786890)
1969
33
Senile cataract. (4175685)
1968
34
Complication at the posterior pole of the eye after senile cataract intracapsular extraction. (5698655)
1968
35
Quantitative study of the variations in the levels of glutathione and ascorbic acid in human lenses with senile cataract. (5728733)
1968
36
Modifications of adenosine triphosphate and of some enzymatic activities during the development of human senile cataract. (6024065)
1967
37
Further studies on ribonucleic acid content and distribution during the development of senile cataract. (6019482)
1967
38
On the significance of the phacoautoantibodies demonstrated in the sera of patients with senile cataract. (6020397)
1967
39
CRYOXTRACTION OF LENS IN SENILE CATARACT SURGERY. (14263323)
1965
40
On the changes in the activity of glutathione reductase on the maturation of senile cataract. (13751487)
1961
41
Biochemical studies on cataract. V. Biochemical genesis of senile cataract. (13411160)
1957
42
Senile cataract; a geriatric problem. (13003680)
1952
43
The senile cataract patient; a pattern for surgical management. (18112879)
1949
44
Comparison of results in a series of senile cataract extractions using three techniques. (18121654)
1948
45
Vitamin C saturation and senile cataract. (21004334)
1945
46
Fuchs's corneal dystrophy complicated by senile cataract. (21065532)
1945
47
Senile Cataract. (20476150)
1938
48
Progress of Senile Cataract under Hygienic Care. (16692694)
1924
49
A study of the nativity, sex, age, occupation, and social condition of 3,436 cases of senile cataract operated upon at the Wills Hospital in Philadelphia. (16692073)
1906
50
On the Extraction of Senile Cataract in its Capsule. (20750458)
1883

Variations for Senile Cataract

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Expression for genes affiliated with Senile Cataract

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Search GEO for disease gene expression data for Senile Cataract.

Pathways for genes affiliated with Senile Cataract

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Pathways related to Senile Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5GSR, G6PD
29.0GSTT1, GSTM1
3
Show member pathways
9.0GSTM1, GSTT1
49.0GSTT1, GSTM1
5
Show member pathways
8.5GSR, GSTM1, GSTT1
6
Show member pathways
glutathione-mediated detoxification I38
glutathione redox reactions I38
glutathione redox reactions II38
4-hydroxy-2-nonenal detoxification38
Glutathione metabolism60
Glutathione metabolism38
8.1GSTM1, G6PD, GSR, GSTT1
7
Show member pathways
8.1GSTT1, GSTM1, GSR, G6PD

Compounds for genes affiliated with Senile Cataract

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Compounds related to Senile Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1o-ethylhydroxylamine459.9GSR, G6PD
2no-dimethylhydroxylamine459.9G6PD, GSR
32,5-adp459.8GSR, G6PD
4thiobarbituric acid459.7G6PD, GSR
5n-(2-hydroxyethyl)valine459.4GSTT1, GSTM1
6drugs for treatment of tuberculosis519.4GSTT1, GSTM1
7methylchloride459.4GSTM1, GSTT1
8trans,trans-muconic acid459.4GSTT1, GSTM1
9ethambutol51 4510.4GSTT1, GSTM1
10s-phenylmercapturic acid459.4GSTM1, GSTT1
11ethylene oxide459.4GSTT1, GSTM1
12glutathion459.4GSTM1, GSR
13styrene oxide459.4GSTM1, GSTT1
142-naphthol459.4GSTM1, GSTT1
15hema459.4GSTM1, GSTT1
16butadiene monoxide459.3GSTT1, GSTM1
171,3-butadiene459.3GSTT1, GSTM1
18vinylchloride459.3GSTM1, GSTT1
19streptomycin51 45 1311.3GSTM1, GSTT1
20pyrazinamide45 51 1311.3GSTT1, GSTM1
21arylamine459.3GSTM1, GSTT1
22vitamin-e459.2GSTT1, G6PD, GSR
23diepoxybutane459.2GSTT1, GSTM1
241-hydroxypyrene459.1GSTT1, GSTM1
25gssg459.1GSTM1, GSR, G6PD
26trimethoprim51 45 1311.1G6PD, GSTM1
27styrene459.1GSTT1, GSTM1
284-hydroxynonenal45 2610.1GSTM1, GSR, G6PD
29toluene459.0GSTT1, GSTM1
30trichloroethylene459.0GSTT1, GSTM1
31alpha tocopherol459.0GSTM1, GSR, G6PD
32isoniazid45 51 1311.0GSTT1, G6PD, GSTM1
33gsts458.9GSR, GSTT1, GSTM1
34Glutathione26 139.9GSR, GSTM1, GSTT1
35manganese superoxide458.9GSTM1, GSTT1, GSR
36carboplatin45 51 1310.9GSTM1, GSTT1, GSR
37nadph45 269.8SERPINF1, GSR, GSTT1, G6PD
38valine458.8GSTT1, GSTM1, G6PD
39cumene hydroperoxide458.5GSR, G6PD, GSTT1, GSTM1
40h2o2458.5G6PD, SERPINF1, GSTM1, GSR
41acetone458.5GSTM1, GSR, G6PD, GSTT1
42malondialdehyde458.5G6PD, GSR, GSTM1, GSTT1
43cyclophosphamide45 51 1310.5GSTT1, GSTM1, GSR, G6PD
44folate458.5G6PD, GSR, GSTM1, GSTT1
45ascorbic acid45 269.5GSTM1, GSTT1, GSR, G6PD
46doxorubicin45 51 1310.5G6PD, GSTT1, GSTM1, GSR
47cisplatin45 51 61 1311.5GSTT1, GSTM1, GSR, G6PD
48creatinine458.4G6PD, GSTM1, GSR, GSTT1
49oxygen45 269.0GSTT1, SERPINF1, G6PD, GSR, GSTM1
50estrogen457.8G6PD, GSTM1, GSTT1, GSR

GO Terms for genes affiliated with Senile Cataract

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Cellular components related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.1GSTT1, GSTM1, GSR, G6PD

Biological processes related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to organic cyclic compoundGO:00140709.3G6PD, GSTT1
2oxidation-reduction processGO:00551149.1GSTT1, G6PD
3glutathione derivative biosynthetic processGO:019016879.1GSTT1, GSTM1
4xenobiotic metabolic processGO:00068059.0GSTM1, GSTT1
5glutathione metabolic processGO:00067498.2GSTT1, GSTM1, GSR, G6PD
6small molecule metabolic processGO:00442818.1GSTT1, G6PD, GSR, GSTM1

Molecular functions related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:00506619.5GSR, G6PD
2glutathione transferase activityGO:00043648.7GSTT1, GSTM1

Products for genes affiliated with Senile Cataract

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  • Antibodies
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  • Kits and Assays

Sources for Senile Cataract

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet