MCID: SNL007
MIFTS: 39

Senile Cataract malady

Eye category

Summaries for Senile Cataract

Sources:
33MalaCards
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MalaCards: Senile Cataract is related to diabetic cataract and primary open angle glaucoma. An important gene associated with Senile Cataract is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Aflatoxin B1 metabolism and Pentose phosphate pathway (hexose monophosphate shunt). The compounds gssg and nadph have been mentioned in the context of this disorder. Related mouse phenotype vision/eye.

Aliases & Classifications for Senile Cataract

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 27ICD9CM, 57SNOMED-CT, 61UMLS, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

senile cataract 8 10 45


External Ids:

Disease Ontology8 DOID:9669
ICD9CM27 366.10, 366.1
NCIt40 C35012
ICD1025 H25

Related Diseases for Senile Cataract

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to senile cataract

Clinical Features for Senile Cataract

Drugs & Therapeutics for Senile Cataract

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Senile Cataract

Drug clinical trials:

Search ClinicalTrials for Senile Cataract

Search NIH Clinical Center for Senile Cataract

Search CenterWatch for Senile Cataract

Genetic Tests for Senile Cataract

Anatomical Context for Senile Cataract

Animal Models for Senile Cataract or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Senile Cataract:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.6GSR, SOD1, GALK1, CRYBB2, CRYAA, CRYGS

Publications for Senile Cataract

Sources:
51PubMed
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Articles related to Senile Cataract:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Synergistic effects of metal ion and the pre-senile cataract-causing G98R alphaA-crystallin: self-aggregation propensities and chaperone activity. (19862354)
2009
2
Implication of glutathione S-transferase M1 and T1 polymorphisms in the development of senile cataract among Egyptians. (20120433)
2009
3
Comparative analysis of the eye function and complications after removal of complicated cataract due to uveitis and senile cataract. (16416988)
2005
4
Blood and lens lipid peroxidation and antioxidant status in normal individuals, senile and diabetic cataractous patients. (12518238)
2002
5
Group II phospholipase A2 content of tears in patients with senile cataract and primary open-angle glaucoma. (11936442)
2002
6
Effect of diabetic retinopathy on redox state of aqueous humor and serum albumin in patients with senile cataract. (11885755)
2001
7
Senile cataract and the absorption activity of cytochrome C oxidase. (11817011)
2001
8
The study on superoxide dismutase and trace element in patients with senile cataract]. (12579780)
2000
9
A case control study of senile cataract in a hospital based population. (9251265)
1996
10
The UV Scenario for Senile Cataract: Fact or Fiction? Proceedings of an expert workshop. Rotterdam, the Netherlands, January 31-February 1, 1994. (7634988)
1994-1995
11
Lens epithelium in senile cataract. (7912592)
1994
12
Case-control study of senile cataract in Japan: a preliminary report. (8145392)
1993
13
Antioxidant activity of plasma from subjects with and without senile cataract. (8223105)
1993
14
Senile cataract-related accumulation of Lewis(x) glycolipid in human lens. (1348055)
1992
15
H2O2-dependent NADH oxidation activity in senile cataractous human lens: its relation to glutathione redox cycle. (2214362)
1990
16
Medical treatment of senile cataract: clinical investigation of bendazac-lysine using objective and subjective methods. (2338248)
1990
17
Measurement of the erythrocyte galactokinase activity in patients with presenile and senile idiopathic cataract. Preliminary study]. (2073390)
1990
18
Senile cataract: survey on cataract patients undergoing cataract surgery, Japan. (2792527)
1989
19
Sunlight, skin sensitivity, and senile cataract. (2916549)
1989
20
Structural conversions of crystallins under senile cataract, dehydration and UV-irradiation studied by X-ray diffraction. (2591500)
1989
21
Idiopathic presenile and senile cataract formation and changes in lactase activity. (3125097)
1987
22
Extracapsular extraction of senile cataract in an Andean condor. (4077639)
1985
23
A comparison of memory function following local and general anaesthesia for extraction of senile cataract. (7124302)
1982
24
Free and total serum tryptophan in senile cataract. (6113522)
1981
25
Diabetes and senile cataract. (7258275)
1981
26
Human senile cataract and Na-K ATP'ase activity in the anterior lens structures with special reference to anterior capsular/subcapsular opacity. (6259880)
1980
27
Senile cataract extraction and diabetes. (1276117)
1976
28
Glutathione and NADP linked enzymes in human senile cataract. (4692229)
1973
29
Protein metabolism in human senile cataract. (5130524)
1971
30
Senile cataract: serum factor producing irreversible precipitation of a lens protein. (5786890)
1969
31
Senile cataract: the influence of blood factors on lens and serum sulfhydryl oxidation. (5358241)
1969
32
Ocular microsurgery with special reference to traumatic and senile cataract. (5786646)
1969
33
Senile cataract. (4175685)
1968
34
Effects of routine extraction of the senile cataract upon the course of primary simple glaucoma. (5667541)
1968
35
Further studies on ribonucleic acid content and distribution during the development of senile cataract. (6019482)
1967
36
On the ability of the blood plasma dialyzate of patients with senile cataract to influence 'in vitro' the activity of some dehydrogenases. (6058324)
1967
37
Case of senile cataract. (5180475)
1966
38
The content of glutathione in various types of senile cataract. (5920281)
1966
39
SOME PROBLEMS CONNECTED WITH THE PATHOGENESIS OF SENILE CATARACT: SYNTHETIC REVIEW OF PERSONAL CONTRIBUTIONS. (14300047)
1965
40
THE REACTIVITY OF THE SERUM PROTEIN-SH GROUPS IN THE SENILE CATARACT. (14167878)
1964
41
FORMED ELEMENTS IN THE HUMAN LENS CAPSULE: WITH SPECIAL REFERENCE TO THEIR ALLEGED ROLE IN THE AETIOLOGY OF SENILE CATARACT. (18170676)
1961
42
The senile cataract patient; a pattern for surgical management. (18112879)
1949
43
The power of projection in senile cataract; does the test of the power of projection afford reliable results? (18879867)
1948
44
Senile cataract, from the standpoint of the general practitioner. (18898151)
1948
45
Operative treatment of senile cataract. (20282752)
1946
46
Posterior sclerotomy and lens extraction in acute glaucoma secondary to senile cataract. (20982429)
1946
47
Causes of Senile Cataract. (16693139)
1937
48
SULPHUR METABOLISM IN SENILE CATARACT. (18169414)
1936
49
POST-OPERATIVE DISTRESS IN CASES OF SENILE CATARACT. (18169410)
1936
50
A MODIFICATION OF THE USUAL METHOD OF REMOVING THE LENS IN THE EXTRACTION OF SENILE CATARACT. (18168422)
1924

Genetic Variations for Senile Cataract

Expression for genes affiliated with Senile Cataract

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for genes affiliated with Senile Cataract

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 12EMD Millipore, 30KEGG
See all sources

Compounds for genes affiliated with Senile Cataract

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Senile Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1gssg4510.6G6PD, GSR
2nadph45 2411.5TALDO1, G6PD
3uric acid45 2411.5G6PD
4manganese superoxide4510.4CAT, GSR, GSTT1
5ionol4510.3SOD1, GSR, CAT
6oxygen45 2411.3SERPINF1, MIP, GSTM1
7propyl gallate4510.3GSR, CAT, SOD1
8guaiacol45 2411.3SOD1, GSR, CAT
9cumene hydroperoxide4510.3GSR, GSTM1, G6PD, GSTT1
103-amino-1,2,4-triazole4510.2CAT, GSR, SOD1
11isoniazid50 45 1112.2GSTM1, GSTT1, G6PD, CAT
12sodium azide4510.2G6PD, CAT, SOD1
13acetone4510.2GSTT1, GSR, G6PD, GSTM1
14thiobarbituric acid4510.2CAT, G6PD, SOD1, GSR
158-oxo-dg4510.2GSTM1, SOD1, GSTT1, CAT
16glutathion4510.2SOD1, CAT, GSR, GSTM1
17fructose-1,6-bisphosphate4510.2GSR, TALDO1, G6PD
18tocopherol4510.2CAT, SOD1, GSR, G6PD
19vitamin a45 11 2412.2CAT, TKT
20mannitol45 1111.2TALDO1, CAT, TKT
21ribose 5-phosphate4510.1TALDO1, TKT, G6PD
22butadiene monoxide4510.1GSTM1, TKT, GSTT1
23alpha lipoic acid4510.1GSR, CAT, G6PD, SOD1
24diphenyleneiodonium4510.1SERPINF1, G6PD, SOD1, CAT
25ebselen4510.1GSR, SOD1, CAT
26betacarotene4510.1GSTM1, GSR, SOD1, CAT
27dehydroascorbic acid45 1111.0SOD1, CAT, TALDO1, GSR, G6PD
284-hydroxynonenal45 2411.0GSTM1, SOD1, G6PD, CAT, GSR
29vitamin-e4510.0CAT, G6PD, SOD1, GSR, GSTT1
30carboplatin45 50 1112.0SOD1, GSTT1, GSR, GSTM1
31benzidine4510.0TKT, GSTT1, GSTM1
32alpha tocopherol4510.0GSR, GSTM1, SOD1, CAT, G6PD
336-phosphogluconate4510.0GSR, G6PD, TALDO1, TKT
34adrenochrome45 2411.0GSTT1, GSTM1, SOD1
35diethyl dithiocarbamate459.9GSR, SOD1, CAT, TKT
36hypoxanthine45 11 2411.9TKT, G6PD, SOD1, CAT
37malondialdehyde459.9G6PD, SOD1, CAT, GSTT1, GSTM1, GSR
38valine459.8GSTM1, GSTT1, GJA8, CRYAA, G6PD
39benzene459.8GSTT1, GSTM1, WRN
40glucose 6-phosphate45 2410.8CAT, TKT, TALDO1, G6PD, SOD1
418-oxoguanine459.7WRN, GSTT1, GSTM1
42h2o2459.7TALDO1, SERPINF1, MIP, WRN, CAT, G6PD
43carbon459.5MIP, TALDO1, TKT, FUCA1, G6PD
44creatinine459.3GSR, GSTM1, TKT, G6PD, SOD1, GSTT1
45n acetylcysteine459.3SERPINF1, G6PD, SOD1, CAT, GSR
46ascorbic acid45 2410.3GSTM1, GSTT1, TALDO1, G6PD, SOD1, CAT
47cisplatin45 50 60 1112.3GSTT1, GSR, GSTM1, TKT, G6PD, WRN
48arginine459.1WRN, SOD1, MIP, GSTT1, GSTM1, GSR
49lactate459.0MIP, SOD1, CAT, TKT, G6PD, TALDO1
50cysteine458.8SOD1, MIP, GSTM1, WRN, CRYAA, SERPINF1

GO Terms for genes affiliated with Senile Cataract

Sources:
16Gene Ontology
See all sources

Cellular components related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.7CAT, SOD1, TKT
2cytosolGO:0058298.4CAT, SOD1, G6PD, GALK1, TALDO1, TKT

Biological processes related to Senile Cataract according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.9G6PD, TALDO1, TKT
2xylulose biosynthetic processGO:0059999.8TKT, TALDO1
3glutathione metabolic processGO:0067499.8GSTT1, GSR, GSTM1, G6PD, SOD1
4lens development in camera-type eyeGO:0020889.8CRYGS, MIP, GJA8
5carbohydrate metabolic processGO:0059759.6TKT, TALDO1, GALK1, G6PD
6visual perceptionGO:0076019.3GJA8, MIP, CRYAA, CRYBB1, CRYBB2
7small molecule metabolic processGO:0442818.6CAT, G6PD, GALK1, TALDO1, TKT, GSTM1

Molecular functions related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.0GSR, G6PD, CAT
2structural constituent of eye lensGO:0052128.9MIP, CRYGS, CRYAA, CRYBB1, CRYBB2, BFSP1
3protein homodimerization activityGO:0428038.5CAT, SOD1, G6PD, CRYBB2, WRN, TKT

Products for genes affiliated with Senile Cataract

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Senile Cataract

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet