MCID: SNL007
MIFTS: 37

Senile Cataract malady

Categories: Eye diseases

Aliases & Classifications for Senile Cataract

Aliases & Descriptions for Senile Cataract:

Name: Senile Cataract 12 52 14

Classifications:



External Ids:

Disease Ontology 12 DOID:9669
ICD10 33 H25
ICD9CM 35 366.1 366.10
NCIt 47 C35012
UMLS 69 C0036646

Summaries for Senile Cataract

MalaCards based summary : Senile Cataract is related to nuclear senile cataract and cortical senile cataract. An important gene associated with Senile Cataract is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Folate Metabolism and NRF2 pathway. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Related Diseases for Senile Cataract

Diseases related to Senile Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 nuclear senile cataract 12.1
2 cortical senile cataract 12.0
3 immature cataract 11.4
4 cataract 10.9
5 mature cataract 10.9
6 differentiated thyroid carcinoma 10.2 GSTM1 GSTT1
7 peptic esophagitis 10.2 CRYAA GSR
8 emery-dreifuss muscular dystrophy, x-linked 10.2 GSTM1 GSTT1
9 tendinopathy 10.2 G6PD SOD1
10 lichen planus pigmentosus 10.2 GSTM1 GSTT1
11 subacute monocytic leukemia 10.2 G6PD GSR
12 villous adenoma 10.2 GSTM1 GSTT1
13 palindromic rheumatism 10.2 BFSP1 CRYAA
14 malignant eyelid melanoma 10.2 BFSP1 CRYAA
15 gastrointestinal tularemia 10.2 GSTM1 GSTT1
16 setariasis 10.2 G6PD SOD1
17 oro-mandibular-limb hypogenesis syndrome 10.2 GSTM1 XRCC1
18 glandular cystitis 10.1 G6PD GSTM1
19 byssinosis 10.1 GSTM1 GSTT1
20 krauss herman holmes syndrome 10.1 ALB G6PD
21 neurological manifestations of pompe disease 10.1 ALB SOD1
22 renal artery disease 10.1 ALB G6PD
23 ectodermal dysplasia bartalos type 10.1 SERPINF1 SOD1
24 mental retardation hypocupremia hypobetalipoproteinemia 10.1 G6PD GSR SOD1
25 whipple disease 10.1 ALB GSR
26 mycobacterium kansasii 10.1 GSTM1 GSTT1 XRCC1
27 pituitary stalk meningioma 10.1 GSTM1 GSTT1 XRCC1
28 hepatic flexure cancer 10.0 GSTM1 GSTT1 XRCC1
29 tunnel subaortic stenosis 10.0 BFSP1 CRYAA
30 esophageal neuroendocrine tumor 10.0 GSTM1 GSTT1
31 stone in bladder diverticulum 10.0 ALB CRYAA
32 open-angle glaucoma 10.0
33 iritis 9.7
34 corneal dystrophy 9.7
35 strabismus 9.7
36 refractive error 9.7
37 obesity 9.7
38 glucose intolerance 9.7
39 keratomalacia 9.7
40 exotropia 9.7
41 myopia 9.7
42 uveitis 9.7
43 tenosynovitis 8.6 ALB BFSP1 CRYAA G6PD GSR GSTM1

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to Senile Cataract

Symptoms & Phenotypes for Senile Cataract

Drugs & Therapeutics for Senile Cataract

Drugs for Senile Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Dipivefrin Approved Phase 4 52365-63-6 3105
5 Analgesics Phase 4
6 Adrenergic Agents Phase 4
7 Adrenergic Agonists Phase 4
8 Neurotransmitter Agents Phase 4
9 Cyclooxygenase Inhibitors Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Anesthetics Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Epinephryl borate Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Ketorolac Tromethamine Phase 4
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Racepinephrine Phase 4
18 Antirheumatic Agents Phase 4
19 Central Nervous System Depressants Phase 4
20 Ophthalmic Solutions Phase 2
21 Pharmaceutical Solutions Phase 2
22
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
23
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759
24
Phenylephrine Approved 59-42-7 6041
25
Oxymetazoline Approved 1491-59-4 4636
26
Ephedrine Approved 299-42-3 9294
27
Tropicamide Approved 1508-75-4 5593
28
Pseudoephedrine Approved 90-82-4 7028
29
Menthol Approved 2216-51-5 16666
30
Povidone-iodine Approved 25655-41-8
31 Propoxycaine Approved 86-43-1
32
Glycerol Approved, Experimental 56-81-5 753
33
Tobramycin Approved, Investigational 32986-56-4 5496 36294
34
Iodine 7553-56-2 807
35 cadexomer iodine
36 insulin
37 Dexamethasone acetate 1177-87-3
38 glucocorticoids
39
protease inhibitors
40 Muscarinic Antagonists
41 Cholinergic Agents
42 Adjuvants, Immunologic
43 Mydriatics
44 Cholinergic Antagonists
45 Nasal Decongestants
46 Gastrointestinal Agents
47 Sodium Channel Blockers
48 Adrenergic alpha-Agonists
49 HIV Protease Inhibitors
50 Tetrahydrozoline

Interventional clinical trials:

(show all 47)
id Name Status NCT ID Phase
1 Tear Film Evaluation After Phacoemulsification Unknown status NCT02238015 Phase 4
2 Outcomes of Phacoemulsification With Torsional Ultrasound Completed NCT01010490 Phase 4
3 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria Completed NCT02150460 Phase 4
4 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4
5 Effect of Optic Edge Design in a Silicone Intraocular Lens on Posterior Capsule Opacification Completed NCT00428363 Phase 4
6 Effect of Minimising Ultrasound Power to 1% During Cataract Surgery on Corneal Endothelium. Unknown status NCT01259349 Phase 3
7 Evaluation of Seelens AF, an Aspheric Intra-Ocular Lens Unknown status NCT00825747 Phase 3
8 Collaborative Italian-American Clinical Trial of Nutritional Supplements and Age-related Cataract (CTNS) Completed NCT00309387 Phase 3
9 Safety and Efficacy Study of an Ophthalmic Solution in Patients With Age-Related Cataract Unknown status NCT00793091 Phase 2
10 Dose-Ranging Study of an Ophthalamic Solution in Patients With Loss of Visual Function Due to Age-Related Nuclear Cataract Unknown status NCT00825721 Phase 2
11 Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population Completed NCT01142960
12 Efficacy of FLACS USFREE Compared to Traditional Surgery Using Ultrasound. Completed NCT03050008
13 Subfoveal Choroidal Thickness After Surgery for Age-related Cataracts Completed NCT02895074
14 Pilot Study: Dynamic Light Scattering Device for Studying Early Changes in Cataract Completed NCT00067483
15 A Prospective Observational Case Series of a Four-ring-haptic Acrylic One-piece IOL Completed NCT01244373
16 Phaco Versus Small Incision Cataract Surgery (SICS) Health Economic Study Completed NCT00762606
17 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
18 Intraocular Pressure Variation by Pneumatic Tonometer Before and After Phacoemulsification Completed NCT03016507
19 Viscoat Versus Visthesia. A Comparative Study of Post-cataract Endothelial Cell Loss Completed NCT02304861
20 Aqualase Versus Torsional ip. A Study on Endothelial Cells, Corneal Edema and Corneal Sensitivity Completed NCT01480557
21 Anterior Capsule Polishing Effect on Effective Lens Position Completed NCT01598428
22 Clinical Analysis of Ocular Parameters Contributing to Intraoperative Pain During Standard Phacoemulsification Completed NCT03031652
23 Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System Completed NCT00078299
24 How Astigmatism Influences Corneal Biomechanics and Intraocular Pressure Completed NCT03162471
25 A Pilot Study Simulating Multifocal Intraocular Lenses in Healthy Subjects Completed NCT01873781
26 Comparison of the Effect of Hydrophobic Acrylic and Silicone 3-piece IOLs on Posterior Capsule Opacification Completed NCT01936701
27 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two IOLs: Hoya iMics Y-60H vs. Bausch&Lomb MI60 (MIMI) Completed NCT01786356
28 Posterior Capsule Opacification Development With Two Different Intraocular Lenses Completed NCT01734343
29 Patient Participation in Free Cataract Surgery Completed NCT02633865
30 A Pilot Study Investigating the Impact of Different IOL Designs on Subjective 2D and 3D Image Quality Completed NCT02409641
31 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two Microincision IOLs: Hoya iMics NY-60 vs Acrysof SN60WF Completed NCT01732484
32 Posterior Capsule Opacification and Frequency of Nd:YAG Treatment and of Two Microincision IOLs: Tecnis ZCB00 and Acrysof SA60AT Completed NCT01742910
33 Performance of a Single-piece Toric Acrylic Intraocular Lens Completed NCT02155959
34 Rotation of an Intraocular Lens - HOYA Vivinex iSert P261 Completed NCT03157375
35 Comparison of In-the-bag Stability Between Single-piece and Three-piece Intraocular Lens Completed NCT02609997
36 Dynamic Light Scattering for Studying Lens Aging and Cataract Formation Completed NCT00081991
37 Long-term Evaluation of Single-piece ACrysof IOL Implantation on Development of Posterior Capsule Opacification Completed NCT01820065
38 Comparison of Manual Super Small Incision Cataract Surgery and Phacoemulsification Completed NCT01146964
39 Evaluation of Posterior Capsule Opacification in Eyes With Diabetes Mellitus Completed NCT01480934
40 Precisight® Intraocular Lens Implantation for Cataract Treatment Recruiting NCT02970487
41 Shanghai High Myopia Study Recruiting NCT03062085
42 Two Different Cataract Surgical Procedures to Prevent Posterior Capsule Opacification Recruiting NCT02445274
43 Neural Compensation, Visual Function and Visual Quality After Monofocal or Multifocal Intraocular Lens Implantation Recruiting NCT02644720
44 Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL Recruiting NCT02817191
45 Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification Cataract Surgery Recruiting NCT02561104
46 Safety and Efficacy of Implantation of Two Multifocal Intraocular Lenses in the Treatment of Senile Cataract Active, not recruiting NCT02966496
47 The Effect of Cataract Surgery on Sleep Quality Not yet recruiting NCT02593669

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

Anatomical Context for Senile Cataract

MalaCards organs/tissues related to Senile Cataract:

39
Eye, Testes, Skin, Retina, Cortex

Publications for Senile Cataract

Articles related to Senile Cataract:

(show top 50) (show all 258)
id Title Authors Year
1
Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. ( 27703255 )
2016
2
The Predictability of Preoperative Pilocarpine-Induced Lens Shift on the Outcomes of Accommodating Intraocular Lenses Implanted in Senile Cataract Patients. ( 27516899 )
2016
3
Prevalence of Pseudoexfoliation Syndrome in Turkish Patients with Senile Cataract. ( 26795697 )
2016
4
The Incidence of Senile Cataract and Glaucoma is Increased in Patients with Plasma Cell Dyscrasias: Etiologic Implications. ( 27328652 )
2016
5
Characteristics of the Anterior Segment Biometry and Corneal Endothelium in Eyes with Pseudoexfoliation Syndrome and Senile Cataract. ( 27800230 )
2015
6
Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1. ( 26884880 )
2015
7
Analytical and physicochemical characterisation of the senile cataract drug dipeptide I^-alanyl-L-histidine (carnosine). ( 26073114 )
2015
8
Comparison of preoperative nepafenac (0.1%) and flurbiprofen (0.03%) eye drops in maintaining mydriasis during small incision cataract surgery in patients with senile cataract: A randomized, double-blind study. ( 26600636 )
2015
9
Serum free Fatty acids level in senile cataract. ( 25079310 )
2014
10
Cost-of-Illness Study of Senile Cataract in the Czech Republic. ( 27202109 )
2014
11
Primary posterior capsular opacification in Indian rural population undergoing cataract surgery for hypermature senile cataract. ( 23966767 )
2013
12
Sequelae of neglected senile cataract. ( 25606266 )
2013
13
Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients. ( 23142692 )
2013
14
Comparison of serum sodium and potassium levels in patients with senile cataract and age-matched individuals without cataract. ( 23552357 )
2013
15
C1824T mutation in the LMNA gene has no association with senile cataract. ( 22079058 )
2012
16
Common genetic link between metabolic syndrome components and senile cataract. ( 22165987 )
2012
17
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. ( 22360021 )
2011
18
Idiopathic phacodonesis in senile cataract patients in Qinghai, China. ( 22553712 )
2011
19
Quantitative assessment of DNA damage directly in lens epithelial cells from senile cataract patients. ( 21224996 )
2011
20
Phospholipid and protein contents of lens proteolipids in human senile cataract. ( 19590524 )
2010
21
Difference in redox status of serum and aqueous humor in senile cataract patients as monitored via the albumin thiol-redox state. ( 21191720 )
2010
22
Association of glutathione S-transferases polymorphisms (GSTM1 and GSTT1) with senile cataract: a meta-analysis. ( 20574021 )
2010
23
Characteristics of the corneal endothelium and pseudoexfoliation syndrome in patients with senile cataract. ( 20456430 )
2010
24
Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. ( 20808731 )
2010
25
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. ( 18982249 )
2009
26
Systemic redox modifications in senile cataract. ( 20446444 )
2009
27
Synergistic effects of metal ion and the pre-senile cataract-causing G98R alphaA-crystallin: self-aggregation propensities and chaperone activity. ( 19862354 )
2009
28
Implication of glutathione S-transferase M1 and T1 polymorphisms in the development of senile cataract among Egyptians. ( 20120433 )
2009
29
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and senile cataract in a Sardinian male population, Italy. ( 19995205 )
2009
30
Oxidative stress markers in aqueous humor of patients with senile cataracts. ( 19172468 )
2009
31
Comparative study of plasma ascorbic acid levels in senile cataract patients and in normal individuals. ( 19219683 )
2009
32
Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. ( 19093039 )
2008
33
Plasma Homocysteine, Folate and Vitamin B(12) levels in senile cataract. ( 23105765 )
2008
34
Evaluation of serum zinc level and plasma SOD activity in senile cataract patients under oxidative stress. ( 23105695 )
2007
35
Plasma redox status and premature onset of senile cataract. ( 17966444 )
2007
36
Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk. ( 16551760 )
2006
37
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. ( 16581614 )
2006
38
Strabismus in senile cataract patients. ( 16213390 )
2005
39
Outcomes of cataract surgery in senile cataract patients at Siriraj Hospital: a prospective observational study. ( 16681057 )
2005
40
Sensory exotropia subsequent to senile cataract. ( 16358383 )
2005
41
Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract. ( 15105821 )
2005
42
Comparative analysis of the eye function and complications after removal of complicated cataract due to uveitis and senile cataract. ( 16416988 )
2005
43
Null genotype of glutathione S-transferase M1 is associated with senile cataract susceptibility in non-smoker females. ( 15194507 )
2004
44
Comparative study of serum Na(+ )and K(+ ) levels in senile cataract patients and normal individuals. ( 15912195 )
2004
45
Changes in glutathione, glutathione-linked enzymes and hexose monophosphate shunt enzymes in senile cataract. ( 15255623 )
2003
46
OXYS rats as a model of senile cataract. ( 14714098 )
2003
47
Popular beliefs regarding the treatment of senile cataract. ( 12131975 )
2002
48
Group II phospholipase A2 content of tears in patients with senile cataract and primary open-angle glaucoma. ( 11936442 )
2002
49
Senile cataract and the absorption activity of cytochrome C oxidase. ( 11817011 )
2001
50
Effect of diabetic retinopathy on redox state of aqueous humor and serum albumin in patients with senile cataract. ( 11885755 )
2001

Variations for Senile Cataract

Expression for Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for Senile Cataract

GO Terms for Senile Cataract

Cellular components related to Senile Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.23 ALB CRYAA G6PD GSR GSTT1 SERPINF1

Biological processes related to Senile Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 retina homeostasis GO:0001895 9.37 ALB SOD1
2 cellular response to oxidative stress GO:0034599 9.33 G6PD GSR SOD1
3 glutathione derivative biosynthetic process GO:1901687 9.32 GSTM1 GSTT1
4 pentose-phosphate shunt GO:0006098 9.26 G6PD TALDO1
5 cellular oxidant detoxification GO:0098869 9.13 ALB GSR GSTT1
6 glutathione metabolic process GO:0006749 9.02 G6PD GSR GSTM1 GSTT1 SOD1

Molecular functions related to Senile Cataract according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.26 G6PD GSR
2 antioxidant activity GO:0016209 9.16 ALB SOD1
3 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
4 structural constituent of eye lens GO:0005212 8.62 BFSP1 CRYAA

Sources for Senile Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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