MCID: SNL007
MIFTS: 36

Senile Cataract malady

Eye diseases category

Summaries for Senile Cataract

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MalaCards based summary: Senile Cataract is related to cataract and open-angle glaucoma. An important gene associated with Senile Cataract is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Sulfation Biotransformation Reaction and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds o-ethylhydroxylamine and no-dimethylhydroxylamine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Aliases & Classifications for Senile Cataract

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 38NCIt, 55SNOMED-CT, 27ICD9CM, 60UMLS, 25ICD10
See all sources

Senile Cataract, Aliases & Descriptions:

Name: Senile Cataract 9 11 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:9669
NCIt38 C35012
ICD9CM27 366.1, 366.10
ICD1025 H25

Related Diseases for Senile Cataract

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Diseases related to Senile Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1cataract31.5G6PD, GSR, GSTT1, SERPINF1
2open-angle glaucoma30.5GSTT1, GSTM1
3cortical senile cataract10.4
4nuclear senile cataract10.4
5toxic encephalopathy10.4GSR
6immature cataract10.3
7diabetic cataract10.2G6PD, GSR
8glucosephosphate dehydrogenase deficiency10.2GSR, G6PD
9methemoglobinemia10.2GSR, G6PD
10thalassemia, hispanic gamma-delta-beta10.2G6PD, GSR
11plasmodium falciparum malaria10.2G6PD, GSR
12vitiligo-associated multiple autoimmune disease susceptibility 110.2G6PD, GSR
13alcohol dependence10.2G6PD, GSR
14obesity10.1
15iritis10.1
16glucose intolerance10.1
17mature cataract10.1
18glucose-6-phosphate dehydrogenase deficiency10.1
19keratomalacia10.1
20corneal dystrophy10.1
21exotropia10.1
22myopia10.1
23refractive error10.1
24scleroderma10.1
25strabismus10.1
26uveitis10.1
27blindness10.1
28schistosomiasis10.0GSTM1, GSR
29brain cancer10.0GSTM1, GSTT1
30asbestosis10.0GSTT1, GSTM1
31mismatch repair cancer syndrome10.0GSTT1, GSTM1
32acute myeloid leukemia, adult10.0GSTT1, GSTM1
33leukoplakia10.0GSTM1, GSTT1
34aplastic anemia10.0GSTT1, GSTM1
35laryngeal squamous cell carcinoma10.0GSTT1, GSTM1
36coronary artery disease10.0GSR, GSTT1
37primary hyperoxaluria10.0G6PD, GSR
38nicotine dependence, protection against10.0GSTM1, GSTT1
39acute lymphoblastic leukemia, childhood10.0GSTM1, GSTT1
40bladder cancer, somatic10.0GSTM1, GSTT1
41basal cell carcinoma10.0GSTT1, GSTM1
42oral cancer10.0GSTT1, GSTM1
43nasopharyngeal carcinoma10.0GSTT1, GSTM1
44acute myocardial infarction9.9GSTM1, GSR
45transitional cell carcinoma9.9GSTT1, GSTM1
46thyroid cancer9.9GSTM1, GSTT1
47gastric adenocarcinoma9.9GSTM1, GSTT1
48atherosclerosis9.9GSTT1, SERPINF1, G6PD
49myelodysplastic syndrome9.9GSTM1, GSTT1
50endometriosis9.9GSTT1, GSTM1

Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to senile cataract

Symptoms for Senile Cataract

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Drugs & Therapeutics for Senile Cataract

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Drug clinical trials:

Search ClinicalTrials for Senile Cataract

Search NIH Clinical Center for Senile Cataract

Genetic Tests for Senile Cataract

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Anatomical Context for Senile Cataract

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MalaCards organs/tissues related to Senile Cataract:

31
Eye, Testes, Cortex, Retina, Skin

Animal Models for Senile Cataract or affiliated genes

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Publications for Senile Cataract

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Articles related to Senile Cataract:

(show top 50)    (show all 248)
idTitleAuthorsYear
1
Primary posterior capsular opacification in Indian rural population undergoing cataract surgery for hypermature senile cataract. (23966767)
2013
2
Sequelae of neglected senile cataract. (25606266)
2013
3
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. (22360021)
2011
4
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. (18982249)
2009
5
Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. (16581614)
2006
6
Strabismus in senile cataract patients. (16213390)
2005
7
Outcomes of cataract surgery in senile cataract patients at Siriraj Hospital: a prospective observational study. (16681057)
2005
8
The study on superoxide dismutase and trace element in patients with senile cataract]. (12579780)
2000
9
Change of water-soluble-protein, urea-soluble-protein and membrane intrinsic protein in human senile cataract. (8758837)
1995
10
Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients. (8595250)
1995
11
Lens epithelium in senile cataract. (7912592)
1994
12
Galactokinase activity in patients with idiopathic presenile and senile cataract. (1305705)
1992
13
Senile cataract-related accumulation of Lewis(x) glycolipid in human lens. (1348055)
1992
14
Senile cataract: a review on free radical related pathogenesis and antioxidant prevention. (15374435)
1991
15
Oxygen and light as risk factors in senile cataract development: experimental studies. (1868942)
1991
16
H2O2-dependent NADH oxidation activity in senile cataractous human lens: its relation to glutathione redox cycle. (2214362)
1990
17
Increase in lens gangliosides due to aging and cataract progression in human senile cataract. (2211013)
1990
18
Nucleotide levels in human lens: regional distribution in different forms of senile cataract. (2920783)
1989
19
Senile cataract and vitamin nutrition. (2601897)
1989
20
Senile cataract: survey on cataract patients undergoing cataract surgery, Japan. (2792527)
1989
21
Amino acid concentrations in serum and aqueous humor from subjects with extreme myopia or senile cataract. (3402067)
1988
22
Idiopathic presenile and senile cataract formation and changes in lactase activity. (3125097)
1987
23
The Emory mouse cataract: an animal model for human senile cataract. (7346236)
1981-1982
24
Senile cataract and plasma tryptophan. (6115288)
1981
25
Plasma tryptophan in senile cataract. (6102340)
1980
26
Human senile cataract and Na-K ATP'ase activity in the anterior lens structures with special reference to anterior capsular/subcapsular opacity. (6259880)
1980
27
Cholesterol and phospholipids in protein fractions of human lens and senile cataract. (667096)
1978
28
Distribution of glycolytic enzymes in nuclear and peripheral lens secretions of the human senile cataract. (891511)
1977
29
Senile cataract extraction and diabetes. (1276117)
1976
30
Proteolipids and phosphatido-peptides in senile cataract. (4660295)
1972
31
Lipoproteins of the crystalline lens and serum factors in senile cataract. (5161574)
1971
32
Senile cataract: serum factor producing irreversible precipitation of a lens protein. (5786890)
1969
33
Senile cataract. (4175685)
1968
34
Complication at the posterior pole of the eye after senile cataract intracapsular extraction. (5698655)
1968
35
Quantitative study of the variations in the levels of glutathione and ascorbic acid in human lenses with senile cataract. (5728733)
1968
36
Modifications of adenosine triphosphate and of some enzymatic activities during the development of human senile cataract. (6024065)
1967
37
Further studies on ribonucleic acid content and distribution during the development of senile cataract. (6019482)
1967
38
On the significance of the phacoautoantibodies demonstrated in the sera of patients with senile cataract. (6020397)
1967
39
CRYOXTRACTION OF LENS IN SENILE CATARACT SURGERY. (14263323)
1965
40
On the changes in the activity of glutathione reductase on the maturation of senile cataract. (13751487)
1961
41
Biochemical studies on cataract. V. Biochemical genesis of senile cataract. (13411160)
1957
42
Senile cataract; a geriatric problem. (13003680)
1952
43
The senile cataract patient; a pattern for surgical management. (18112879)
1949
44
Comparison of results in a series of senile cataract extractions using three techniques. (18121654)
1948
45
Vitamin C saturation and senile cataract. (21004334)
1945
46
Fuchs's corneal dystrophy complicated by senile cataract. (21065532)
1945
47
Senile Cataract. (20476150)
1938
48
Progress of Senile Cataract under Hygienic Care. (16692694)
1924
49
A study of the nativity, sex, age, occupation, and social condition of 3,436 cases of senile cataract operated upon at the Wills Hospital in Philadelphia. (16692073)
1906
50
On the Extraction of Senile Cataract in its Capsule. (20750458)
1883

Variations for Senile Cataract

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Expression for genes affiliated with Senile Cataract

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Search GEO for disease gene expression data for Senile Cataract.

Pathways for genes affiliated with Senile Cataract

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Pathways related to Senile Cataract according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5GSR, G6PD
29.0GSTT1, GSTM1
3
Show member pathways
9.0GSTM1, GSTT1
49.0GSTT1, GSTM1
5
Show member pathways
8.5GSR, GSTM1, GSTT1
6
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
8.1GSTM1, G6PD, GSR, GSTT1
7
Show member pathways
8.1GSTT1, GSTM1, GSR, G6PD

Compounds for genes affiliated with Senile Cataract

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Compounds related to Senile Cataract according to GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1o-ethylhydroxylamine439.9GSR, G6PD
2no-dimethylhydroxylamine439.9G6PD, GSR
32,5-adp439.8GSR, G6PD
4thiobarbituric acid439.7G6PD, GSR
5n-(2-hydroxyethyl)valine439.4GSTT1, GSTM1
6drugs for treatment of tuberculosis499.4GSTT1, GSTM1
7methylchloride439.4GSTM1, GSTT1
8trans,trans-muconic acid439.4GSTT1, GSTM1
9ethambutol49 4310.4GSTT1, GSTM1
10s-phenylmercapturic acid439.4GSTM1, GSTT1
11ethylene oxide439.4GSTT1, GSTM1
12glutathion439.4GSTM1, GSR
13styrene oxide439.4GSTM1, GSTT1
142-naphthol439.4GSTM1, GSTT1
15hema439.4GSTM1, GSTT1
16butadiene monoxide439.3GSTT1, GSTM1
171,3-butadiene439.3GSTT1, GSTM1
18vinylchloride439.3GSTM1, GSTT1
19streptomycin49 43 1211.3GSTM1, GSTT1
20pyrazinamide43 49 1211.3GSTT1, GSTM1
21arylamine439.3GSTM1, GSTT1
22vitamin-e439.2GSTT1, G6PD, GSR
23diepoxybutane439.2GSTT1, GSTM1
241-hydroxypyrene439.1GSTT1, GSTM1
25gssg439.1GSTM1, GSR, G6PD
26trimethoprim49 43 1211.1G6PD, GSTM1
27styrene439.1GSTT1, GSTM1
284-hydroxynonenal43 2410.1GSTM1, GSR, G6PD
29toluene439.0GSTT1, GSTM1
30trichloroethylene439.0GSTT1, GSTM1
31alpha tocopherol439.0GSTM1, GSR, G6PD
32isoniazid43 49 1211.0GSTT1, G6PD, GSTM1
33gsts438.9GSR, GSTT1, GSTM1
34Glutathione24 129.9GSR, GSTM1, GSTT1
35manganese superoxide438.9GSTM1, GSTT1, GSR
36carboplatin43 49 1210.9GSTM1, GSTT1, GSR
37nadph43 249.8SERPINF1, GSR, GSTT1, G6PD
38valine438.8GSTT1, GSTM1, G6PD
39cumene hydroperoxide438.5GSR, G6PD, GSTT1, GSTM1
40h2o2438.5G6PD, SERPINF1, GSTM1, GSR
41acetone438.5GSTM1, GSR, G6PD, GSTT1
42malondialdehyde438.5G6PD, GSR, GSTM1, GSTT1
43cyclophosphamide43 49 1210.5GSTT1, GSTM1, GSR, G6PD
44folate438.5G6PD, GSR, GSTM1, GSTT1
45ascorbic acid43 249.5GSTM1, GSTT1, GSR, G6PD
46doxorubicin43 49 1210.5G6PD, GSTT1, GSTM1, GSR
47cisplatin43 49 59 1211.5GSTT1, GSTM1, GSR, G6PD
48creatinine438.4G6PD, GSTM1, GSR, GSTT1
49oxygen43 249.0GSTT1, SERPINF1, G6PD, GSR, GSTM1
50estrogen437.8G6PD, GSTM1, GSTT1, GSR

GO Terms for genes affiliated with Senile Cataract

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Cellular components related to Senile Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.1GSTT1, GSTM1, GSR, G6PD

Biological processes related to Senile Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to organic cyclic compoundGO:00140709.3GSTT1, G6PD
2oxidation-reduction processGO:00551149.1GSTT1, G6PD
3glutathione derivative biosynthetic processGO:019016879.1GSTT1, GSTM1
4xenobiotic metabolic processGO:00068059.0GSTT1, GSTM1
5glutathione metabolic processGO:00067498.2GSTT1, GSTM1, GSR, G6PD
6small molecule metabolic processGO:00442818.1G6PD, GSR, GSTM1, GSTT1

Molecular functions related to Senile Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:00506619.5GSR, G6PD
2glutathione transferase activityGO:00043648.7GSTT1, GSTM1

Products for genes affiliated with Senile Cataract

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  • Antibodies
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  • Lysates
  • Antibodies
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  • Kits and Assays

Sources for Senile Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet