Senile Cataract malady

MalaCards: Senile Cataract, also known as bilateral cataracts (disorder), is related to cataracts, autosomal dominant and cerulean cataract. An important gene associated with Senile Cataract is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are Oxidative Stress Pathway (Erythrocyte) and Pathway_PA165980337. The compounds ionol and nadph have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are homeostasis/metabolism and vision/eye.

Aliases & Descriptions:

senile cataract 6 8 32 bilateral cataracts (disorder) 43

Diseases related to senile cataract by text searches and GeneDecks gene sharing:

(show top 50)    (show all 353)

id	Related Disease	Score	Top Affiliating Genes
1	cataracts, autosomal dominant	29.7	GJA8, CRYBB1, CRYBB2
2	cerulean cataract	29.6	MIP, CRYBB2
3	posterior polar cataract	29.6	BFSP1, CRYBB2, CRYGS
4	cataract-glaucoma	29.0	GSR, AKR1B1
5	congenital cataracts	28.8	MIP, GJA8, CRYBB1, CRYBB2, GALK1
6	diabetic cataract	27.3	SERPINF1, MIP, GSR, FAM46D, CAT, AKR1B1
7	diabetic retinopathy	26.0	SERPINF1, GSTM1, GSTT1, FGF2, ALB, AKR1B1
8	cataract	25.3	SERPINF1, BFSP1, LAMA3, FUCA1, MIP, GSR
9	diabetes mellitus	25.2	FUCA1, GSR, GSTM1, GSTT1, FGF2, ALB
10	favism	13.5	CAT, G6PD
11	meningitis and encephalitis	13.5	CAT, SOD1
12	methemoglobinemia	13.5	GSR, G6PD, SOD1
13	meningococcal infection	13.5	GSR, G6PD, SOD1
14	cataract microcornea syndrome	13.5	GJA8, CRYBB1
15	aseptic meningitis	13.5	CAT, G6PD, SOD1
16	hyperphenylalaninemia	13.4	CAT, G6PD, SOD1
17	chronic granulomatous disease	13.4	CAT, G6PD, SOD1
18	rosacea	13.4	GSTM1, GSTT1, SOD1
19	alcoholic pancreatitis	13.4	GSTM1, GSTT1, CAT
20	oral cavity cancer	13.4	GSTM1, GSTT1, CAT
21	neurocirculatory asthenia	13.4	GSR, CAT, SOD1
22	asbestosis	13.3	GSTM1, GSTT1, CAT, G6PD
23	multinodular goiter	13.3	GSR, CAT, G6PD, SOD1
24	hereditary pancreatitis	13.3	GSR, GSTM1, GSTT1, SOD1
25	friedreich ataxia	13.3	GSR, G6PD, SOD1
26	exfoliation syndrome	13.3	GSTM1, GSTT1, CAT, SOD1
27	pneumoconiosis	13.3	GSTM1, GSTT1, CAT, SOD1
28	tardive dyskinesia	13.3	GSTM1, GSTT1, CAT, SOD1
29	cutaneous leishmaniasis	13.2	CAT, G6PD, SOD1
30	toxic encephalopathy	13.2	GSR, GSTM1, GSTT1, CAT
31	acute diarrhea	13.2	ALB, G6PD
32	cervical intraepithelial neoplasia	13.2	GSTM1, GSTT1, CAT, G6PD
33	alcohol abuse	13.2	GSR, CAT, SOD1
34	sensorineural hearing loss	13.2	GSTM1, GSTT1, G6PD, SOD1
35	plasmodium falciparum malaria	13.2	GSR, GSTM1, G6PD
36	avascular necrosis of femoral head	13.1	CAT, SOD1
37	paracoccidioidomycosis	13.1	GSR, ALB, G6PD
38	leber hereditary optic neuropathy	13.1	GSR, GSTM1, GSTT1, CAT, SOD1
39	barrett's esophagus	13.1	GSTM1, GSTT1, CAT, SOD1
40	transaldolase deficiency	13.1	TKT, TALDO1
41	renovascular hypertension	13.1	ALB, CAT, SOD1
42	porphyria cutanea tarda	13.1	GSTM1, GSTT1, ALB
43	maple syrup urine disease	13.1	ALB, CAT, SOD1
44	hepatoblastoma	13.1	SERPINF1, GSR, CAT, G6PD, GALK1
45	adult respiratory distress syndrome	13.0	ALB, CAT, SOD1
46	head injury	13.0	GSR, ALB, SOD1
47	hydrops fetalis	13.0	ALB, G6PD, TALDO1
48	alcoholic liver cirrhosis	13.0	GSTM1, GSTT1, ALB
49	neonatal jaundice	13.0	GSTM1, GSTT1, ALB, G6PD
50	xeroderma pigmentosum	13.0	GSR, GSTT1, CAT, TALDO1, SOD1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to senile cataract:

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MGI Mouse Phenotypes related to senile cataract:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	6.7	WRN, SOD1, TALDO1, G6PD, AKR1B1, CAT
2	vision/eye phenotype	MP:0005391	5.6	SERPINF1, GALK1, WRN, SOD1, TKT, CRYGS

Articles related to senile cataract:

(show all 20)

id	Title	Authors	Year	Affiliating Genes
1	Association of glutathione S-transferases polymorphis ms (GSTM1 and GSTT1) with senile cataract: a meta-analysis. (20574021)	Sun L.... Wang C.	2010	GSTT1, GSTM1
2	Lack of association of the WRN C1367T polymorphism wi th senile cataract in the Israeli population. (20808731)	Ehrenberg M.... Goldenberg-Cohen N.	2010	WRN
3	Implication of glutathione S-transferase M1 and T1 po lymorphisms in the development of senile cataract among Egyptians. (20120433)	Abdel Azeem A.A.... Amr K.	2009	GSTT1, GSTM1
4	The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. (18982249)	Yildirim Z.... Kilic N.	2009	SOD1
5	Glucose-6-phosphate dehydrogenase (G6PD) deficiency a nd senile cataract in a Sardinian male population, Italy. (19995205)	Pinna A.... Solinas G.	2009	G6PD
6	Oxidative stress markers in aqueous humor of patients with senile cataracts. (19172468)	Sawada H.... Abe H.	2009	SOD1
7	Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. (19093039)	Panz T.... Krukar-Baster K.	2008	SOD1
8	Decreased glucose-6-phosphate-dehydrogenase (G6PD) activity and risk of senile cataract in Taiwan. (16581614)	Wan G.H.... Chiu D.T.	2006	G6PD
9	Occupational sunlight exposure, polymorphism of glutathione S-transferase M1, and senile cataract risk. (16551760)	Saadat M.... Farvardin-Jahromi M.	2006	GSTM1
10	Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract. (15105821)	Segev F.... Assia E.I.	2005	SERPINF1, BFSP1
11	Null genotype of glutathione S-transferase M1 is associated with senile cataract susceptibility in non-smoker females. (15194507)	Saadat M.... Saadat H.	2004	GSTT1, GSTM1
12	Changes in glutathione, glutathione-linked enzymes and hexose monophosphate shunt enzymes in senile cataract. (15255623)	George S.... Shashidhar S.	2003	GSR, G6PD, TALDO1
13	Effect of diabetic retinopathy on redox state of aqueous humor and serum albumin in patients with senile cataract. (11885755)	Kawai K.... Era S.	2001	ALB
14	The study on superoxide dismutase and trace element in patients with senile cataract (12579780)	Yang W.... Li Z.	2000	SOD1
15	Expression of transforming growth factor (TGF)-alpha, TGF-beta(2) and interleukin 8 messenger RNA in postsurgical and cultured lens epithelial cells obtained from patients with senile cataracts. (10502054)	Nishi O.... Ohmoto Y.	1999	FGF2
16	Relationship between GSTM1 genotype and susceptibility to senile cataract (11835784)	Hao Y.... Liu T.	1999	GSTM1
17	Variation in the glycosidase activity of human lens d uring aging and with advance of senile cataract. (8593455)	Kamei A.	1995	FUCA1
18	Galactokinase activity in patients with idiopathic presenile and senile cataract. (1305705)	Simonelli F.... Rinaldi E.	1992	GALK1
19	H2O2-dependent NADH oxidation activity in senile cataractous human lens: its relation to glutathione redox cycle. (2214362)	Bando M.... Obazawa H.	1990	GSR
20	Senile cataract and glucose-6-phosphate dehydrogenase deficiency in Indians. (2100077)	Bhatia R.P.... Dubey B.	1990	G6PD

Genes related to senile cataract according to GeneCards:

(show all 23)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
2	GSTM1	glutathione S-transferase mu 1	11.0	Publications
3	GSR	glutathione reductase	11.0	Publications
4	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
5	SOD1	superoxide dismutase 1, soluble	11.0	Publications
6	GSTT1	glutathione S-transferase theta 1	11.0	Publications
7	CAT	catalase	11.0
8	GALK1	galactokinase 1	11.0	Publications
9	CRYGS	crystallin, gamma S	11.0
10	CRYBB1	crystallin, beta B1	11.0
11	TALDO1	transaldolase 1	11.0	Publications
12	CRYBB2	crystallin, beta B2	11.0
13	GJA8	gap junction protein, alpha 8, 50kDa	11.0
14	FUCA1	fucosidase, alpha-L- 1, tissue	11.0	Publications
15	BFSP1	beaded filament structural protein 1, filensin	11.0	Publications
16	FAM46D	family with sequence similarity 46, member D	11.0
17	MIP	major intrinsic protein of lens fiber	11.0
18	WRN	Werner syndrome, RecQ helicase-like	11.0	Publications
19	LAMA3	laminin, alpha 3	11.0
20	TKT	transketolase	11.0	Publications
21	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	11.0
22	FGF2	fibroblast growth factor 2 (basic)	11.0	Publications
23	ALB	albumin	11.0	Publications

Pathways related to senile cataract according to GeneDecks:

(show all 11)

id	Pathway	Score	Top Affiliating Genes
1	Oxidative Stress Pathway (Erythrocyte)34	10.1	GSR, SOD1, CAT
2	Pathway_PA16598033734	10.1	SOD1, CAT, GSR
3	Oxidative Stress Pathway (Erythrocyte)34	10.1	SOD1, CAT, GSR
4	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	10.1	GSTM1, GSTT1, SOD1
5	Glutathione metabolism41	9.9	GSR, GSTM1, GSTT1
6	Glutathione metabolism20	9.9	G6PD, GSTT1, GSTM1, GSR
7	Insulin effects increased synthesis of Xylulose-5-Phosphate38	9.7	TKT, TALDO1
8	Glutathione metabolism10	9.6	GSR, GSTM1, GSTT1
9	Naphthalene metabolism41	9.6	AKR1B1, GSTT1, GSTM1
10	Naphthalene metabolism10	9.5	AKR1B1, GSTT1, GSTM1
11	Pentose phosphate pathway20	9.4	TALDO1, TKT, G6PD

Compounds related to senile cataract according to GeneDecks:

(show top 50)    (show all 140)

id	Compound	Score	Top Affiliating Genes
1	ionol32	10.7	CAT
2	nadph32 18	11.6	TALDO1
3	propyl gallate32	10.2	CAT, SOD1, GSR
4	guaiacol32 18	11.2	CAT, GSR, SOD1
5	3-amino-1,2,4-triazole32	10.2	SOD1, CAT, GSR
6	cumene hydroperoxide32	10.2	G6PD, GSTT1, GSTM1, GSR
7	glutathion32	10.1	SOD1, CAT, GSTM1, GSR
8	thiobarbituric acid32	10.1	SOD1, GSR, G6PD, CAT
9	acetone32	10.1	GSR, GSTT1, G6PD, GSTM1
10	sodium azide32	10.1	SOD1, CAT, G6PD
11	tocopherol32	10.1	G6PD, SOD1, CAT, GSR
12	silymarin32	10.0	AKR1B1, GSR
13	diphenyleneiodonium32	10.0	SERPINF1, SOD1, G6PD, CAT
14	fructose-1,6-bisphosphate32	10.0	GSR, G6PD, TALDO1
15	gssg32	10.0	SOD1, GSR, GSTM1, CAT, G6PD
16	butadiene monoxide32	9.9	TKT, GSTT1, GSTM1
17	manganese superoxide32	9.9	SOD1, GSTM1, GSR, CAT, GSTT1
18	adrenochrome32 18	10.9	SOD1, GSTM1, GSTT1
19	dehydroascorbic acid32	9.9	G6PD, TALDO1, CAT, GSR, SOD1
20	fenton32	9.9	CAT, SOD1, GSR
21	ribose 5-phosphate32	9.9	TKT, G6PD, TALDO1
22	betacarotene32	9.9	GSR, CAT, SOD1, GSTM1
23	vitamin-e32	9.9	CAT, G6PD, GSR, SOD1, GSTT1
24	ebselen32	9.8	GSR, CAT, SOD1
25	malondialdehyde32	9.8	CAT, GSR, GSTM1, GSTT1, G6PD, SOD1
26	6-phosphogluconate32	9.7	TALDO1, TKT, G6PD, GSR
27	diethyl dithiocarbamate32	9.7	SOD1, TKT, CAT, GSR
28	benzyl alcohol32	9.7	AKR1B1, SOD1, CAT
29	hypoxanthine32 9 18 9	12.7	TKT, CAT, G6PD, SOD1
30	benzidine32	9.6	GSTT1, GSTM1, TKT
31	gsno32	9.6	GSR, SOD1, AKR1B1, CAT
32	uric acid32 18	10.5	SOD1, G6PD, ALB, GSR, CAT
33	alpha lipoic acid32	9.5	AKR1B1, SOD1, GSR, CAT, G6PD
34	folate32	9.4	GSTM1, GSR, GSTT1, ALB, G6PD
35	alpha tocopherol32	9.4	GSR, SOD1, CAT, ALB, GSTM1, G6PD
36	8-oxoguanine32	9.4	GSTM1, WRN, GSTT1
37	glucose 6-phosphate32 18	10.4	CAT, TALDO1, GSR, SOD1, G6PD, TKT
38	4-hydroxynonenal32 18	10.3	AKR1B1, GSR, G6PD, SOD1, GSTM1, CAT
39	h2o232	9.3	MIP, AKR1B1, TALDO1, WRN
40	doxorubicin32 34 9 9	12.1	GSTM1, GSTT1, GSR, G6PD, AKR1B1, CAT
41	citrate32	9.1	FGF2, AKR1B1, CAT
42	salicylic acid32	9.1	ALB, CAT, AKR1B1, G6PD
43	ascorbic acid32 18	10.0	GSTM1, GSTT1, AKR1B1, TKT, G6PD, TALDO1
44	oxygen32 18	9.7	GSTM1, GSTT1, MIP, SERPINF1, TALDO1, AKR1B1
45	carbon32	8.6	AKR1B1, G6PD, MIP, TKT, FUCA1, TALDO1
46	vitamin a32 9 18 9	11.3	CAT, ALB, GSR, TKT, SOD1, GSTM1
47	creatinine32	8.3	GSTT1, ALB, G6PD, TKT, GSTM1, AKR1B1
48	cysteine32	8.1	SERPINF1, WRN, MIP, GSTM1, ALB, AKR1B1
49	lactate32	7.4	AKR1B1, G6PD, TKT, CAT, FUCA1, GSTM1
50	mannitol32 9 9	9.0	G6PD, MIP, FGF2, ALB, CAT, AKR1B1

Cellular components related to senile cataract according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	7.7	GSR, SOD1, TALDO1, TKT, G6PD, AKR1B1

Biological processes related to senile cataract according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	glutathione metabolic process	GO:006749	9.9	GSR, GSTT1, G6PD, SOD1
2	xylulose biosynthetic process	GO:005999	9.8	TKT, TALDO1
3	pentose-phosphate shunt, non-oxidative branch	GO:009052	9.7	TKT, TALDO1
4	lens development in camera-type eye	GO:002088	9.7	CRYGS, GJA8, MIP
5	pentose-phosphate shunt	GO:006098	9.7	TALDO1, TKT, G6PD
6	C21-steroid hormone biosynthetic process	GO:006700	9.0	FGF2, AKR1B1
7	visual perception	GO:007601	9.0	MIP, GJA8, CRYBB1, CRYBB2
8	carbohydrate metabolic process	GO:005975	8.6	GALK1, TALDO1, TKT, G6PD, AKR1B1
9	small molecule metabolic process	GO:044281	7.7	GALK1, TALDO1, TKT, G6PD, AKR1B1, CAT

Molecular functions related to senile cataract according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	NADP binding	GO:050661	9.9	GSR, CAT, G6PD
2	structural constituent of eye lens	GO:005212	8.9	BFSP1, MIP, CRYBB1, CRYBB2, CRYGS
3	protein homodimerization activity	GO:042803	8.2	WRN, SOD1, TKT, G6PD, CRYBB2, CAT