MCID: SNL007
MIFTS: 46

Senile Cataract malady

Eye diseases category

Summaries for Senile Cataract

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32MalaCards
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MalaCards: Senile Cataract is related to cataract and diabetic cataract. An important gene associated with Senile Cataract is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Aflatoxin B1 metabolism and Pentose phosphate pathway (hexose monophosphate shunt). The compounds gssg and nadph have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin, and related mouse phenotype vision/eye.

Aliases & Classifications for Senile Cataract

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 56SNOMED-CT, 60UMLS, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

senile cataract 8 10 44


External Ids:

Disease Ontology8 DOID:9669
ICD9CM27 366.10, 366.1
NCIt39 C35012
ICD1025 H25

Related Diseases for Senile Cataract

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Senile Cataract:



Diseases related to senile cataract

Clinical Features for Senile Cataract

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Drugs & Therapeutics for Senile Cataract

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Senile Cataract

Search CenterWatch for Senile Cataract

Genetic Tests for Senile Cataract

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Anatomical Context for Senile Cataract

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32MalaCards
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MalaCards organs/tissues related to Senile Cataract:

32
Eye, Testes, Skin, Retina, Cortex

Animal Models for Senile Cataract or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Senile Cataract:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.6GSR, SOD1, GALK1, CRYBB2, CRYAA, CRYGS

Publications for Senile Cataract

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50PubMed
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Articles related to Senile Cataract:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
C1824T mutation in the LMNA gene has no association with senile cataract. (22079058)
2012
2
Phospholipid and protein contents of lens proteolipids in human senile cataract. (19590524)
2010
3
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and senile cataract in a Sardinian male population, Italy. (19995205)
2009
4
Plasma Homocysteine, Folate and Vitamin B(12) levels in senile cataract. (23105765)
2008
5
Comparative study of serum Na(+ )and K(+ ) levels in senile cataract patients and normal individuals. (15912195)
2004
6
Popular beliefs regarding the treatment of senile cataract. (12131975)
2002
7
The study on superoxide dismutase and trace element in patients with senile cataract]. (12579780)
2000
8
Topographical distribution of lactate dehydrogenase activity in human clear eye lenses and in lenses with different types of senile cataract: a histochemical investigation. (9349944)
1997
9
Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients. (8595250)
1995
10
Population-based study of risk factors in senile cataract. (7895879)
1994
11
Explant culture of human lens epithelial cells from senile cataract patients. (8295370)
1993
12
Antioxidant activity of plasma from subjects with and without senile cataract. (8223105)
1993
13
Galactitol is not a cause of senile cataract. (1597290)
1992
14
Senile cataract: a review on free radical related pathogenesis and antioxidant prevention. (15374435)
1991
15
Discrepancy between onset of early lens changes and onset of senile cataract: the case for cellular defense systems in the human eye lens. (1868938)
1991
16
Increased magnesium in aqueous humour from patients with senile cataract. (1750327)
1991
17
Senile cataract and glucose-6-phosphate dehydrogenase deficiency in Indians. (2100077)
1990
18
Gammaglobulins and immunocomplexes in aqueous humor and serum of patients with senile cataract. (2453778)
1985
19
Mechanisms of senile cataract formation. (6431351)
1984
20
Senile cataract. The case against light. (6877773)
1983
21
Effect of a nonsteroidal gametic factor linked to DNA on senile cataract in man. (7093183)
1982
22
The Emory mouse cataract: an animal model for human senile cataract. (7346236)
1981-1982
23
Senile cataract and plasma tryptophan. (6115288)
1981
24
Environmental temperature and senile cataract. (7257059)
1980
25
Glucose tolerance tests in 200 patients with senile cataract. (7426592)
1980
26
Variations of lens thickness in relation to biomicroscopic types of human senile cataract. (419966)
1979
27
Senile cataract model: biochemistry and morphology of the ageing lens [proceedings]. (645484)
1978
28
Five hundred planned extracapsular extractions with irido-capsular and iris clip lens implantation in senile cataract. (302928)
1977
29
Characteristics of alpha-crystallin in human senile cataract. (4720449)
1973
30
Proteolipids and phosphatido-peptides in senile cataract. (4660295)
1972
31
Further investigations on the reactivity of the P-SH groups: relationship between senile cataract and diabetes. (5398637)
1969
32
Modifications of adenosine triphosphate and of some enzymatic activities during the development of human senile cataract. (6024065)
1967
33
The serum content of sialic acid in the course of senile cataract. (5630719)
1967
34
Senile cataract and its relationship to the glucose-tolerance curve. (5920625)
1966
35
Keratomalacia following senile cataract extraction. (5830426)
1965
36
Further investigations on some properties of the blood of patients with senile cataract. (5864921)
1965
37
Prolapse of the iris in senile cataract extraction and its prevention. (13735205)
1961
38
Geographic distribution of senile cataract. (13849867)
1960
39
Indications for senile cataract extraction. (14446129)
1960
40
Biochemical studies on cataract. V. Biochemical genesis of senile cataract. (13411160)
1957
41
Problems arising in the management of senile cataract. (13162745)
1954
42
Senile cataract; a geriatric problem. (13003680)
1952
43
The power of projection in senile cataract; does the test of the power of projection afford reliable results? (18879867)
1948
44
Vitamin C saturation and senile cataract. (21004334)
1945
45
Myopic Detachments of the Retina associated with Senile Cataract in Both Eyes. (19991927)
1939
46
Senile Cataract. (20476150)
1938
47
GLUTATHIONE IN THE BLOOD IN SENILE CATARACT AND OTHER OCULAR CONDITIONS. (18169342)
1936
48
SENILE CATARACT - A STUDY OF THE BIOLOGY AND CHEMISTRY OF THE CRYSTALLINE LENS. (18169208)
1934
49
The Treatment of a Case of Cyclo-Iritis Following Senile Cataract Extraction. (20316669)
1928
50
Progress of Senile Cataract under Hygienic Care. (16692694)
1924

Genetic Variations for Senile Cataract

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Expression for genes affiliated with Senile Cataract

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Senile Cataract

Search GEO for disease gene expression data for Senile Cataract.

Pathways for genes affiliated with Senile Cataract

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Senile Cataract

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Senile Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1gssg4410.6G6PD, GSR
2nadph44 2411.5TALDO1, G6PD
3uric acid44 2411.5G6PD
4manganese superoxide4410.4CAT, GSR, GSTT1
5ionol4410.3SOD1, GSR, CAT
6oxygen44 2411.3SERPINF1, MIP, GSTM1
7propyl gallate4410.3GSR, CAT, SOD1
8guaiacol44 2411.3SOD1, GSR, CAT
9cumene hydroperoxide4410.3GSR, GSTM1, G6PD, GSTT1
103-amino-1,2,4-triazole4410.2CAT, GSR, SOD1
11isoniazid49 44 1112.2GSTM1, GSTT1, G6PD, CAT
12sodium azide4410.2G6PD, CAT, SOD1
13acetone4410.2GSTT1, GSR, G6PD, GSTM1
14thiobarbituric acid4410.2CAT, G6PD, SOD1, GSR
158-oxo-dg4410.2GSTM1, SOD1, GSTT1, CAT
16glutathion4410.2SOD1, CAT, GSR, GSTM1
17fructose-1,6-bisphosphate4410.2GSR, TALDO1, G6PD
18tocopherol4410.2CAT, SOD1, GSR, G6PD
19vitamin a44 11 2412.2CAT, TKT
20mannitol44 1111.2TALDO1, CAT, TKT
21ribose 5-phosphate4410.1TALDO1, TKT, G6PD
22butadiene monoxide4410.1GSTM1, TKT, GSTT1
23alpha lipoic acid4410.1GSR, CAT, G6PD, SOD1
24diphenyleneiodonium4410.1SERPINF1, G6PD, SOD1, CAT
25ebselen4410.1GSR, SOD1, CAT
26betacarotene4410.1GSTM1, GSR, SOD1, CAT
27dehydroascorbic acid44 1111.0SOD1, CAT, TALDO1, GSR, G6PD
284-hydroxynonenal44 2411.0GSTM1, SOD1, G6PD, CAT, GSR
29vitamin-e4410.0CAT, G6PD, SOD1, GSR, GSTT1
30carboplatin44 49 1112.0SOD1, GSTT1, GSR, GSTM1
31benzidine4410.0TKT, GSTT1, GSTM1
32alpha tocopherol4410.0GSR, GSTM1, SOD1, CAT, G6PD
336-phosphogluconate4410.0GSR, G6PD, TALDO1, TKT
34adrenochrome44 2411.0GSTT1, GSTM1, SOD1
35diethyl dithiocarbamate449.9GSR, SOD1, CAT, TKT
36hypoxanthine44 11 2411.9TKT, G6PD, SOD1, CAT
37malondialdehyde449.9G6PD, SOD1, CAT, GSTT1, GSTM1, GSR
38valine449.8GSTM1, GSTT1, GJA8, CRYAA, G6PD
39benzene449.8GSTT1, GSTM1, WRN
40glucose 6-phosphate44 2410.8CAT, TKT, TALDO1, G6PD, SOD1
418-oxoguanine449.7WRN, GSTT1, GSTM1
42h2o2449.7TALDO1, SERPINF1, MIP, WRN, CAT, G6PD
43carbon449.5MIP, TALDO1, TKT, FUCA1, G6PD
44creatinine449.3GSR, GSTM1, TKT, G6PD, SOD1, GSTT1
45n acetylcysteine449.3SERPINF1, G6PD, SOD1, CAT, GSR
46ascorbic acid44 2410.3GSTM1, GSTT1, TALDO1, G6PD, SOD1, CAT
47cisplatin44 49 59 1112.3GSTT1, GSR, GSTM1, TKT, G6PD, WRN
48arginine449.1WRN, SOD1, MIP, GSTT1, GSTM1, GSR
49lactate449.0MIP, SOD1, CAT, TKT, G6PD, TALDO1
50cysteine448.8SOD1, MIP, GSTM1, WRN, CRYAA, SERPINF1

GO Terms for genes affiliated with Senile Cataract

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16Gene Ontology
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Cellular components related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.7TKT, SOD1, CAT
2cytosolGO:0058298.4GSTT1, CAT, SOD1, G6PD, GALK1, TALDO1

Biological processes related to Senile Cataract according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.9G6PD, TALDO1, TKT
2xylulose biosynthetic processGO:0059999.8TKT, TALDO1
3glutathione metabolic processGO:0067499.8GSTT1, GSR, GSTM1, G6PD, SOD1
4lens development in camera-type eyeGO:0020889.8CRYGS, MIP, GJA8
5carbohydrate metabolic processGO:0059759.6TKT, TALDO1, GALK1, G6PD
6visual perceptionGO:0076019.3GJA8, MIP, CRYAA, CRYBB1, CRYBB2
7small molecule metabolic processGO:0442818.6CAT, G6PD, GALK1, TALDO1, TKT, GSTM1

Molecular functions related to Senile Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:05066110.0GSR, G6PD, CAT
2structural constituent of eye lensGO:0052128.9MIP, CRYGS, CRYAA, CRYBB1, CRYBB2, BFSP1
3protein homodimerization activityGO:0428038.5CAT, SOD1, G6PD, CRYBB2, WRN, TKT

Products for genes affiliated with Senile Cataract

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Sources for Senile Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet