MCID: SNL010
MIFTS: 19

Senile Systemic Amyloidosis malady

Bone diseases category

Summaries for Senile Systemic Amyloidosis

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 Familial amyloid polyneuropathy (FAP), also called transthyretin-related hereditary amyloidosis,... more...

MalaCards: Senile Systemic Amyloidosis is related to amyloidosis and dementia. An important gene associated with Senile Systemic Amyloidosis is TTR (transthyretin), and among its related pathways is Alzheimers Disease Pathway. The compounds trifluoroethanol and guanidine have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Senile Systemic Amyloidosis

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
senile systemic amyloidosis:
Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

senile systemic amyloidosis 48 60


External Ids:

ICD10 via Orphanet26 E85.8

Related Diseases for Senile Systemic Amyloidosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Senile Systemic Amyloidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.4MAPT, TTR
2dementia30.2MAPT
3cerebral amyloid angiopathy30.2TTR, MAPT
4transthyretin amyloidosis10.7
5carpal tunnel syndrome10.3
6polyneuropathy10.3
7angina pectoris10.2
8cerebritis10.2
9dilated cardiomyopathy10.2
10familial transthyretin amyloidosis10.2
11glaucoma10.0TTR
12myositis10.0MAPT
13nephrotic syndrome10.0A2M
14amyloid tumor10.0TTR, MAPT
15central nervous system disease10.0TTR, MAPT
16parkinson's disease10.0MAPT, TTR

Graphical network of diseases related to Senile Systemic Amyloidosis:



Diseases related to senile systemic amyloidosis

Clinical Features for Senile Systemic Amyloidosis

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Drugs & Therapeutics for Senile Systemic Amyloidosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Senile Systemic Amyloidosis

Drug clinical trials:

Search ClinicalTrials for Senile Systemic Amyloidosis

Search NIH Clinical Center for Senile Systemic Amyloidosis

Search CenterWatch for Senile Systemic Amyloidosis

Genetic Tests for Senile Systemic Amyloidosis

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Anatomical Context for Senile Systemic Amyloidosis

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32MalaCards
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MalaCards organs/tissues related to Senile Systemic Amyloidosis:

32
Bone

Animal Models for Senile Systemic Amyloidosis or affiliated genes

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Publications for Senile Systemic Amyloidosis

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Genetic Variations for Senile Systemic Amyloidosis

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Expression for genes affiliated with Senile Systemic Amyloidosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Senile Systemic Amyloidosis

Search GEO for disease gene expression data for Senile Systemic Amyloidosis.

Pathways for genes affiliated with Senile Systemic Amyloidosis

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Sources:
51QIAGEN
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Pathways related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MAPT, A2M

Compounds for genes affiliated with Senile Systemic Amyloidosis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1trifluoroethanol44 1110.6TTR, MAPT
2guanidine44 11 2411.6TTR, MAPT
3vitamin b12449.6TTR, MAPT
4sodium dodecylsulfate449.6MAPT, TTR
5urea44 11 2411.5TTR, MAPT
6folate449.5TTR, MAPT
7nicotine44 49 28 1112.5MAPT, TTR
8valine449.4TTR, MAPT
9glycerol44 11 2411.4TTR, MAPT
10phosphatidylserine44 28 1111.3TTR, MAPT
11fibrinogen449.0TTR, A2M
12methionine449.0TTR, MAPT
13serine448.4A2M, MAPT, TTR

GO Terms for genes affiliated with Senile Systemic Amyloidosis

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Sources:
16Gene Ontology
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Molecular functions related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1MAPT, A2M

Products for genes affiliated with Senile Systemic Amyloidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Senile Systemic Amyloidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet