MCID: SNL010
MIFTS: 29

Senile Systemic Amyloidosis malady

Bone diseases, Rare diseases categories

Summaries for Senile Systemic Amyloidosis

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Familial amyloid polyneuropathy (FAP), also called transthyretin-related hereditary amyloidosis,... more...

MalaCards: Senile Systemic Amyloidosis is related to amyloidosis and cerebral amyloid angiopathy. An important gene associated with Senile Systemic Amyloidosis is TTR (transthyretin), and among its related pathways are Alzheimers Disease Pathway and Degradation of the extracellular matrix. The compounds trifluoroethanol and guanidine have been mentioned in the context of this disorder. Affiliated tissues include bone and heart.

Aliases & Classifications for Senile Systemic Amyloidosis

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Sources:
50Orphanet, 63UMLS, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

50
senile systemic amyloidosis:
Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

senile systemic amyloidosis 50 63


External Ids:

ICD10 via Orphanet27 E85.8

Related Diseases for Senile Systemic Amyloidosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Senile Systemic Amyloidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.4MAPT, TTR
2cerebral amyloid angiopathy30.3MAPT, TTR
3polyneuropathy10.3
4angina pectoris10.2
5cerebritis10.2
6carpal tunnel syndrome10.2
7dementia10.2
8dilated cardiomyopathy10.2
9amyloidosis cerebral10.2
10thromboembolism10.2
11amyloid tumor10.0MAPT, TTR
12central nervous system disease10.0TTR, MAPT
13malignant glioma10.0MAPT, TTR
14parkinson's disease10.0MAPT, TTR
15alzheimer's disease9.9A2M, MAPT, TTR

Graphical network of diseases related to Senile Systemic Amyloidosis:



Diseases related to senile systemic amyloidosis

Symptoms for Senile Systemic Amyloidosis

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Drugs & Therapeutics for Senile Systemic Amyloidosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Senile Systemic Amyloidosis

Drug clinical trials:

Search ClinicalTrials for Senile Systemic Amyloidosis

Search NIH Clinical Center for Senile Systemic Amyloidosis

Search CenterWatch for Senile Systemic Amyloidosis

Genetic Tests for Senile Systemic Amyloidosis

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Anatomical Context for Senile Systemic Amyloidosis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Senile Systemic Amyloidosis:

34
Bone, Heart

Animal Models for Senile Systemic Amyloidosis or affiliated genes

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Publications for Senile Systemic Amyloidosis

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Sources:
53PubMed
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Articles related to Senile Systemic Amyloidosis:

(show all 35)
idTitleAuthorsYear
1
Senile systemic amyloidosis: clinical features at presentation and outcome. (23608605)
2013
2
Senile systemic amyloidosis localized to the stomach. (23650956)
2013
3
Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy. (24111636)
2013
4
Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosis. (21764155)
2013
5
Arterial thromboembolism in senile systemic amyloidosis: report of two cases. (22583098)
2012
6
Defining the diagnosis in echocardiographically suspected senile systemic amyloidosis. (22789945)
2012
7
Senile systemic amyloidosis: are regional differences real or do they reflect different diagnostic suspicion and use of techniques? (22620969)
2012
8
Diagnostic value of abdominal wall fat pad biopsy in senile systemic amyloidosis. (22004460)
2011
9
Clinical features and survival in senile systemic amyloidosis: comparison to familial transthyretin cardiomyopathy. (21838471)
2011
10
Vesicular senile systemic amyloidosis. (21838478)
2011
11
Clinicopathological features of senile systemic amyloidosis: an ante- and post-mortem study. (21822203)
2011
12
Senile systemic amyloidosis: clinical pictures and diagnostic criteria. (21838470)
2011
13
A case of a senile systemic amyloidosis patient presenting with angina pectoris and dilated cardiomyopathy. (21607172)
2011
14
Senile systemic amyloidosis in an aged savannah monkey (Cercopithecus aethiops) with tenosynovial degeneration. (20075604)
2010
15
Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity. (19065297)
2008
16
Early cardiac involvement in senile systemic amyloidosis: a case report. (18266122)
2008
17
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study. (18382889)
2008
18
Senile systemic amyloidosis, cerebral amyloid angiopathy, and dementia in a very old Finnish population. (17062383)
2006
19
Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis. (15983293)
2005
20
Heart transplantation in a 68-year-old patient with senile systemic amyloidosis. (15816901)
2005
21
Transthyretin-derived senile systemic amyloidosis: clinicopathologic and structural considerations. (14640042)
2003
22
Early pathogenesis of cardiac amyloid deposition in senile systemic amyloidosis: close relationship between amyloid deposits and the basement membranes of myocardial cells. (12647215)
2003
23
Senile systemic amyloidosis presenting as bilateral carpal tunnel syndrome. (12557754)
2002
24
Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis. (11310831)
2001
25
Biophysical analysis of normal transthyretin: implications for fibril formation in senile systemic amyloidosis. (11409037)
2001
26
Myocardial Tc-99m MDP uptake on a bone scan in senile systemic amyloidosis with cardiac involvement. (11043729)
2000
27
Senile systemic amyloidosis--a case report. (10862300)
1999
28
Amyloid fibril composition and transthyretin gene structure in senile systemic amyloidosis. (7474944)
1995
29
Senile systemic amyloidosis: a clinico-pathological study of twelve patients with massive amyloid infiltration. (1864673)
1991
30
The transthyretin cDNA sequence is normal in transthyretin-derived senile systemic amyloidosis. (2015890)
1991
31
Fibril in senile systemic amyloidosis is derived from normal transthyretin. (2320592)
1990
32
A homozygous transthyretin variant associated with senile systemic amyloidosis: evidence for a late-onset disease of genetic etiology. (2349941)
1990
33
Evidence that the amyloid fibril protein in senile systemic amyloidosis is derived from normal prealbumin. (3135807)
1988
34
Prealbumin in Swedish patients with senile systemic amyloidosis and familial amyloidotic polyneuropathy. (2983415)
1985
35
Senile systemic amyloidosis. (6507586)
1984

Variations for Senile Systemic Amyloidosis

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Expression for genes affiliated with Senile Systemic Amyloidosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Senile Systemic Amyloidosis

Search GEO for disease gene expression data for Senile Systemic Amyloidosis.

Pathways for genes affiliated with Senile Systemic Amyloidosis

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Sources:
51PathCards, 54QIAGEN, 56Reactome
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Pathways related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1A2M, MAPT
2
Show member pathways
9.0A2M, TTR

Compounds for genes affiliated with Senile Systemic Amyloidosis

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1trifluoroethanol46 1210.7MAPT, TTR
2guanidine46 25 1211.7MAPT, TTR
3vitamin b12469.7MAPT, TTR
4sodium dodecylsulfate469.7TTR, MAPT
5urea46 25 1211.7MAPT, TTR
6folate469.7MAPT, TTR
7nicotine46 30 52 1212.6TTR, MAPT
8valine469.6MAPT, TTR
9glycerol46 25 1211.6MAPT, TTR
10phosphatidylserine46 30 1211.6MAPT, TTR
11methionine469.6TTR, MAPT
12paraffin469.6MAPT, TTR
13genistein46 30 62 3 25 1214.5TTR, MAPT
14proline469.5MAPT, TTR
15cyclosporin a46 30 6211.5MAPT, TTR
16glutamine469.4TTR, MAPT
17lactate469.4MAPT, TTR
18dopamine46 30 25 1212.3MAPT, TTR
19fibrinogen469.3A2M, TTR
20creatinine469.2TTR, MAPT
21heparin46 30 25 1212.1A2M, MAPT
22aspartate469.0MAPT, TTR
23serine468.8TTR, MAPT, A2M

GO Terms for genes affiliated with Senile Systemic Amyloidosis

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17Gene Ontology
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Biological processes related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.0A2M, TTR

Molecular functions related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1A2M, MAPT

Products for genes affiliated with Senile Systemic Amyloidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Senile Systemic Amyloidosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet