MCID: SNL010
MIFTS: 24

Senile Systemic Amyloidosis malady

Bone category

Summaries for Senile Systemic Amyloidosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Familial amyloid polyneuropathy (FAP), also called transthyretin-related hereditary amyloidosis,... more...

MalaCards: Senile Systemic Amyloidosis is related to amyloidosis and cerebral amyloid angiopathy. An important gene associated with Senile Systemic Amyloidosis is TTR (transthyretin), and among its related pathways is Alzheimers Disease Pathway. The compounds trifluoroethanol and guanidine have been mentioned in the context of this disorder. Affiliated tissues include heart and b cells.

Aliases & Classifications for Senile Systemic Amyloidosis

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone


Characteristics (Orphanet epidemiological data):

49
senile systemic amyloidosis:
Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

senile systemic amyloidosis 49 61


External Ids:

ICD10 via Orphanet26 E85.8

Related Diseases for Senile Systemic Amyloidosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Senile Systemic Amyloidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis31.4TTR, MAPT
2cerebral amyloid angiopathy30.2MAPT, TTR
3transthyretin amyloidosis10.7
4carpal tunnel syndrome10.3
5angina pectoris10.2
6familial transthyretin amyloidosis10.2
7al amyloidosis10.2
8amyloidosis cerebral10.2
9star syndrome10.2
10familial amyloid cardiomyopathy10.2
11thromboembolism10.2
12glaucoma10.0TTR
13dementia10.0MAPT
14myositis10.0MAPT
15nephrotic syndrome10.0A2M
16amyloid tumor10.0MAPT, TTR
17central nervous system disease10.0MAPT, TTR
18parkinson's disease10.0MAPT, TTR

Graphical network of diseases related to Senile Systemic Amyloidosis:



Diseases related to senile systemic amyloidosis

Clinical Features for Senile Systemic Amyloidosis

Drugs & Therapeutics for Senile Systemic Amyloidosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Senile Systemic Amyloidosis

Drug clinical trials:

Search ClinicalTrials for Senile Systemic Amyloidosis

Search NIH Clinical Center for Senile Systemic Amyloidosis

Search CenterWatch for Senile Systemic Amyloidosis

Genetic Tests for Senile Systemic Amyloidosis

Anatomical Context for Senile Systemic Amyloidosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Senile Systemic Amyloidosis:

33
Heart, B cells

Animal Models for Senile Systemic Amyloidosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Senile Systemic Amyloidosis

Sources:
51PubMed
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Articles related to Senile Systemic Amyloidosis:

(show all 42)
idTitleAuthorsYear
1
Senile systemic amyloidosis: clinical features at presentation and outcome. (23608605)
2013
2
Senile systemic amyloidosis localized to the stomach. (23650956)
2013
3
Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy. (24111636)
2013
4
Skeletal scintigraphy indicates disease severity of cardiac involvement in patients with senile systemic amyloidosis. (21764155)
2013
5
Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis? (22362898)
2012
6
Arterial thromboembolism in senile systemic amyloidosis: report of two cases. (22583098)
2012
7
Defining the diagnosis in echocardiographically suspected senile systemic amyloidosis. (22789945)
2012
8
Senile systemic amyloidosis: are regional differences real or do they reflect different diagnostic suspicion and use of techniques? (22620969)
2012
9
Diagnostic value of abdominal wall fat pad biopsy in senile systemic amyloidosis. (22004460)
2011
10
Clinical features and survival in senile systemic amyloidosis: comparison to familial transthyretin cardiomyopathy. (21838471)
2011
11
Vesicular senile systemic amyloidosis. (21838478)
2011
12
Clinicopathological features of senile systemic amyloidosis: an ante- and post-mortem study. (21822203)
2011
13
Senile systemic amyloidosis: clinical pictures and diagnostic criteria. (21838470)
2011
14
A case of a senile systemic amyloidosis patient presenting with angina pectoris and dilated cardiomyopathy. (21607172)
2011
15
Senile systemic amyloidosis in an aged savannah monkey (Cercopithecus aethiops) with tenosynovial degeneration. (20075604)
2010
16
Non-senile wild-type transthyretin systemic amyloidosis presenting as bilateral carpal tunnel syndrome. (18601659)
2008
17
Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity. (19065297)
2008
18
Early cardiac involvement in senile systemic amyloidosis: a case report. (18266122)
2008
19
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study. (18382889)
2008
20
Senile systemic amyloidosis, cerebral amyloid angiopathy, and dementia in a very old Finnish population. (17062383)
2006
21
Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis. (15983293)
2005
22
Heart transplantation in a 68-year-old patient with senile systemic amyloidosis. (15816901)
2005
23
Transthyretin-derived senile systemic amyloidosis: clinicopathologic and structural considerations. (14640042)
2003
24
Early pathogenesis of cardiac amyloid deposition in senile systemic amyloidosis: close relationship between amyloid deposits and the basement membranes of myocardial cells. (12647215)
2003
25
Senile systemic amyloidosis starting as bilateral carpal and left ulnar tunnel syndrome. (14606726)
2003
26
Senile systemic amyloidosis presenting as bilateral carpal tunnel syndrome. (12557754)
2002
27
Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis. (11310831)
2001
28
Biophysical analysis of normal transthyretin: implications for fibril formation in senile systemic amyloidosis. (11409037)
2001
29
Codeposition of apolipoprotein A-IV and transthyretin in senile systemic (ATTR) amyloidosis. (11467836)
2001
30
Myocardial Tc-99m MDP uptake on a bone scan in senile systemic amyloidosis with cardiac involvement. (11043729)
2000
31
Senile systemic amyloidosis--a case report. (10862300)
1999
32
The premortem recognition of systemic senile amyloidosis with cardiac involvement. (8873510)
1996
33
Amyloid fibril composition and transthyretin gene structure in senile systemic amyloidosis. (7474944)
1995
34
Senile systemic amyloidosis: a clinico-pathological study of twelve patients with massive amyloid infiltration. (1864673)
1991
35
The transthyretin cDNA sequence is normal in transthyretin-derived senile systemic amyloidosis. (2015890)
1991
36
Fibril in senile systemic amyloidosis is derived from normal transthyretin. (2320592)
1990
37
A homozygous transthyretin variant associated with senile systemic amyloidosis: evidence for a late-onset disease of genetic etiology. (2349941)
1990
38
Systemic senile amyloidosis. Identification of a new prealbumin (transthyretin) variant in cardiac tissue: immunologic and biochemical similarity to one form of familial amyloidotic polyneuropathy. (2646319)
1989
39
Evidence that the amyloid fibril protein in senile systemic amyloidosis is derived from normal prealbumin. (3135807)
1988
40
Prealbumin in Swedish patients with senile systemic amyloidosis and familial amyloidotic polyneuropathy. (2983415)
1985
41
Senile systemic amyloidosis. (6507586)
1984
42
PRIMARY SYSTEMIC AMYLOIDOSIS; CEREBRAL INVOLVEMENT AND SENILE PLAQUE FORMATION. (14105304)
1964

Genetic Variations for Senile Systemic Amyloidosis

Expression for genes affiliated with Senile Systemic Amyloidosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Senile Systemic Amyloidosis

Search GEO for disease gene expression data for Senile Systemic Amyloidosis.

Pathways for genes affiliated with Senile Systemic Amyloidosis

Sources:
52QIAGEN
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Pathways related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MAPT, A2M

Compounds for genes affiliated with Senile Systemic Amyloidosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
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Compounds related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1trifluoroethanol45 1110.6TTR, MAPT
2guanidine45 11 2411.6TTR, MAPT
3vitamin b12459.6TTR, MAPT
4sodium dodecylsulfate459.6MAPT, TTR
5urea45 11 2411.5TTR, MAPT
6folate459.5TTR, MAPT
7nicotine45 50 29 1112.5MAPT, TTR
8valine459.4TTR, MAPT
9glycerol45 11 2411.4TTR, MAPT
10phosphatidylserine45 29 1111.3TTR, MAPT
11fibrinogen459.0TTR, A2M
12methionine459.0TTR, MAPT
13serine458.4A2M, MAPT, TTR

GO Terms for genes affiliated with Senile Systemic Amyloidosis

Sources:
16Gene Ontology
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Molecular functions related to Senile Systemic Amyloidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1MAPT, A2M

Products for genes affiliated with Senile Systemic Amyloidosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Senile Systemic Amyloidosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet