MCID: SNS001
MIFTS: 54

Sensorineural Hearing Loss

Categories: Ear diseases

Aliases & Classifications for Sensorineural Hearing Loss

MalaCards integrated aliases for Sensorineural Hearing Loss:

Name: Sensorineural Hearing Loss 12 29 14 69
Sensory Hearing Loss 12 52 69
Hearing Loss, High-Frequency 42 69
Hearing Loss, Central 42 69
Perceptive Hearing Loss or Deafness 12
High Frequency Hearing Loss 12
High-Frequency Hearing Loss 12
Hearing Loss High-Frequency 52
Hearing Loss, Sensorineural 42
Hearing Loss Sensorineural 52
High Frequency Deafness 12
Perceptive Hearing Loss 12
Sensorineural Deafness 12
Deafness Sensorineural 52
Central Hearing Loss 12
Perceptive Deafness 12

Classifications:



Summaries for Sensorineural Hearing Loss

MalaCards based summary : Sensorineural Hearing Loss, also known as sensory hearing loss, is related to deafness, autosomal recessive 9 and deafness, autosomal dominant 36. An important gene associated with Sensorineural Hearing Loss is GJB2 (Gap Junction Protein Beta 2), and among its related pathways/superpathways are Neural Crest Differentiation and Gap junction trafficking. The drugs Cisplatin and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related phenotypes are Effect on mitosis and hearing/vestibular/ear

Wikipedia : 72 Sensorineural hearing loss (SNHL) is a type of hearing loss, or deafness, in which the root cause lies... more...

Related Diseases for Sensorineural Hearing Loss

Diseases related to Sensorineural Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 605)
id Related Disease Score Top Affiliating Genes
1 deafness, autosomal recessive 9 32.9 GJB2 OTOF
2 deafness, autosomal dominant 36 32.7 GJB2 TMC1
3 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 32.5 GJB2 MITF SLC26A4
4 deafness, autosomal dominant 11 32.2 GJB2 MYO6 MYO7A OTOF
5 deafness, autosomal dominant 3a 32.1 GJB2 GJB3 GJB6
6 deafness, autosomal recessive 23 31.9 COCH MYO7A
7 macrothrombocytopenia and progressive sensorineural deafness 31.8 MYH9 MYO6 MYO7A
8 deafness, autosomal recessive 37 31.7 COCH MYH9 MYO6 MYO7A
9 deafness, autosomal dominant 2a 31.6 COCH GJB2 GJB6 KCNQ4 WFS1
10 hyperglycemia 30.5 GJB2 MITF
11 autosomal recessive nonsyndromic deafness 8 30.1 GJB2 MYH9 MYO6 MYO7A OTOF SLC26A4
12 x-linked nonsyndromic deafness 29.6 COCH EYA4 MYO6 MYO7A TMC1 WFS1
13 deafness, autosomal recessive 53 29.5 COCH EYA4 GJB2 MYO7A OTOF SLC26A4
14 autosomal recessive nonsyndromic deafness 26.3 COCH EYA4 GJB2 GJB3 GJB6 KCNQ4
15 split-hand/foot malformation 1 with sensorineural hearing loss 12.3
16 corneal endothelial dystrophy and perceptive deafness 12.3
17 sudden sensorineural hearing loss 12.3
18 cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia 12.3
19 hypoparathyroidism, sensorineural deafness, and renal dysplasia 12.2
20 ocular albinism with sensorineural deafness 12.2
21 cleft palate, midfacial hypoplasia, triangular facies, and sensorineural hearing loss 12.1
22 dfna6/14/38 nonsyndromic low frequency sensorineural hearing loss 12.0
23 sensorineural hearing loss-early graying-essential tremor syndrome 12.0
24 nonsyndromic hereditary sensorineural hearing loss 12.0
25 hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 12.0
26 ectodermal dysplasia, sensorineural hearing loss, and distinctive facial features 12.0
27 autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome 12.0
28 bjornstad syndrome 11.8
29 deafness, x-linked 2 11.7
30 capos syndrome 11.7
31 fibromatosis, gingival, with progressive deafness 11.7
32 deafness, autosomal dominant 22 11.7
33 deafness, autosomal dominant 1 11.7
34 cardiomyopathy, dilated, 1j 11.7
35 heimler syndrome 1 11.6
36 cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorinural hearing loss 11.6
37 deafness enamel hypoplasia nail defects 11.6
38 alport syndrome, autosomal dominant 11.5
39 epilepsy, hearing loss, and mental retardation syndrome 11.5
40 lichtenstein-knorr syndrome 11.5
41 neuropathy, hereditary sensory, type ie 11.5
42 hereditary sensory and autonomic neuropathy type 1e 11.5
43 split-foot malformation with mesoaxial polydactyly 11.5
44 x-linked non-syndromic sensorineural deafness type dfn 11.5
45 autosomal dominant non-syndromic sensorineural deafness type dfna 11.5
46 pendred syndrome 11.4
47 deafness, autosomal recessive 48 11.3
48 deafness, autosomal dominant 41 11.2
49 deafness, autosomal dominant 56 11.2
50 deafness, autosomal dominant 70 11.2

Comorbidity relations with Sensorineural Hearing Loss via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Sensorineural Hearing Loss:



Diseases related to Sensorineural Hearing Loss

Symptoms & Phenotypes for Sensorineural Hearing Loss

GenomeRNAi Phenotypes related to Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Effect on mitosis GR00257-A-2 9.02 COCH DLX5 EYA4 GJB3 MYH9

MGI Mouse Phenotypes related to Sensorineural Hearing Loss:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 10.2 GJB6 KCNQ4 MITF MYH9 MYO6 MYO7A
2 behavior/neurological MP:0005386 10.11 ATP6V1B1 COL2A1 DLX5 GJB6 MITF MYO6
3 homeostasis/metabolism MP:0005376 10.03 ATP6V1B1 COL2A1 COL4A5 EYA4 GJB2 GJB3
4 immune system MP:0005387 9.81 COL2A1 COL4A5 EYA4 GJB2 GJB3 GJB6
5 nervous system MP:0003631 9.73 COL2A1 DLX5 GJB2 GJB6 KCNQ4 MITF
6 no phenotypic analysis MP:0003012 9.23 GJB2 GJB3 GJB6 MITF MYH9 MYO7A

Drugs & Therapeutics for Sensorineural Hearing Loss

Drugs for Sensorineural Hearing Loss (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 1,Phase 2 15663-27-1 84093 441203 2767
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
5 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
6 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
7 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
8 Hormones Phase 4,Phase 2,Phase 3,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
11 Antiemetics Phase 4,Phase 3,Phase 2
12 Autonomic Agents Phase 4,Phase 3,Phase 2
13 BB 1101 Phase 4,Phase 3,Phase 2
14 Dexamethasone 21-phosphate Phase 4,Phase 2
15 Dexamethasone acetate Phase 4,Phase 3,Phase 2 1177-87-3
16 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2
17 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
18
protease inhibitors Phase 4,Phase 3,Phase 2
19
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
20
Ganciclovir Approved, Investigational Phase 3,Phase 2 82410-32-0 3454
21
Valganciclovir Approved, Investigational Phase 3,Phase 2 175865-60-8 64147
22
Magnesium Sulfate Approved, Vet_approved Phase 3 7487-88-9 24083
23
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
24
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
25
Acetylcysteine Approved, Investigational Phase 2, Phase 3,Phase 1 616-91-1 12035
26
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
27
Povidone Approved Phase 3 9003-39-8
28
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
29
Iron Approved Phase 2, Phase 3 7439-89-6 23925
30
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
31
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
32
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
33
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
34
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
35 Anti-Infective Agents Phase 3,Phase 2,Phase 1
36 Antiviral Agents Phase 3,Phase 2,Phase 1
37 Ganciclovir triphosphate Phase 3,Phase 2
38 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
39 Acyclovir Phase 2, Phase 3
40 Analgesics Phase 3,Phase 1,Phase 2
41 Anesthetics Phase 3,Phase 1,Phase 2
42 Anti-Arrhythmia Agents Phase 3
43 Anticonvulsants Phase 3
44 calcium channel blockers Phase 3
45 Calcium, Dietary Phase 3
46 Central Nervous System Depressants Phase 3
47 Tocolytic Agents Phase 3
48 Methylprednisolone acetate Phase 3
49 Methylprednisolone Hemisuccinate Phase 3
50 Neuroprotective Agents Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 130)

id Name Status NCT ID Phase Drugs
1 Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone Treatment Completed NCT01372904 Phase 4 Dexamethasone Phosphate
2 Diaphragmatic Movement Before and After Stellate Ganglion Block : A Ultrasonographic Study Completed NCT01054378 Phase 4
3 The Esteem® Hearing Implant Post Approval Study Completed NCT02666222 Phase 4
4 Bed Rest for Idiopathic Sudden Sensorineural Hearing Loss Unknown status NCT00416143 Phase 2, Phase 3 prednisone - oral corticosteroid 1mg/kg/D for 1 week
5 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment Unknown status NCT02005822 Phase 3 Valganciclovir
6 Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease Unknown status NCT01729767 Phase 2, Phase 3 Acyclovir;Placebo
7 Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors Unknown status NCT01216800 Phase 3
8 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
9 Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With Sudden Hearing Loss Completed NCT00335920 Phase 3 Dexamethasone-dihydrogenphosphate (4mg/ml)
10 Evaluation of a Binaural Spatialization Method for Hearing Aids Completed NCT02693704 Phase 2, Phase 3
11 Sudden Deafness Treatment Trial Completed NCT00097448 Phase 3 prednisone;methylprednisolone sodium succinate
12 Efficacy and Safety of AM-111 as Acute Sudden Sensorineural Hearing Loss Treatment Recruiting NCT02809118 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
13 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
14 AM-111 in the Treatment of Acute Inner Ear Hearing Loss Active, not recruiting NCT02561091 Phase 3 AM-111 0.4 mg/ml;AM-111 0.8 mg/ml
15 Evaluation of the Benefit of Antiviral Treatment With Valganciclovir on Congenital CMV Infection-related Deafness on Hearing and Balance Not yet recruiting NCT02606266 Phase 2, Phase 3 Valganciclovir
16 Randomized Controlled Trial of Valganciclovir for Asymptomatic Cytomegalovirus Infected Hearing Impaired Infants Not yet recruiting NCT03107871 Phase 3 Valganciclovir;Simple Syrup
17 Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy Not yet recruiting NCT02882477 Phase 2, Phase 3 Deferiprone;Acetylcysteine;Sitagliptin and Metformin
18 Congenital Cytomegalovirus: Efficacy of Antiviral Treatment in a Randomized Controlled Trial Terminated NCT01655212 Phase 3 Valganciclovir
19 Autoimmunity in Inner Ear Disease Terminated NCT00000361 Phase 3 Corticosteroids;Methotrexate
20 Effectiveness of P02 Digital Hearing Aids Unknown status NCT01902914 Phase 1, Phase 2
21 Transtympanic Ringer's Lactate for the Prevention of Cisplatin Ototoxicity Unknown status NCT01108601 Phase 1, Phase 2 Ringer's Lactate (0.03% Ciprofloxacin)
22 Efficacy of AM-111 in Patients With Acute Sensorineural Hearing Loss Completed NCT00802425 Phase 2 AM-111;placebo
23 A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2 Anakinra
24 Study to Evaluate SPI-1005 in Adults With Meniere's Disease Completed NCT02603081 Phase 1, Phase 2 SPI-1005
25 Efficacy of AM 101 in Patients With Acute Inner Ear Tinnitus Completed NCT00860808 Phase 2 AM-101
26 Efficacy of Eltrombopag to Improve Thrombocytopenia of MYH9-related Disease Completed NCT01133860 Phase 2 eltrombopag
27 The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2 gevokizumab
28 High Dose Oral Steroids in Sudden Sensorineural Hearing Loss Recruiting NCT03255473 Phase 2 Dexamethasone;Prednisone
29 Efficacy, Safety, and Tolerability of Ancrod in Patients With Sudden Hearing Loss Recruiting NCT01621256 Phase 1, Phase 2 Ancrod;Saline solution
30 Effectiveness of Therapy Via Telemedicine Following Cochlear Implants Recruiting NCT02497690 Phase 2
31 Congenital CMV and Hearing Loss in Children up to 4 Years of Age: Treating With Valganciclovir Therapy Recruiting NCT01649869 Phase 2 Valcyte (Valganciclovir hydrochloride) Powder for oral solution;Placebo
32 SPI-1005 for Prevention and Treatment of Aminoglycoside Induced Ototoxicity Enrolling by invitation NCT02819856 Phase 1, Phase 2 Placebo;SPI-1005 Ebselen 200mg Capsule x1;SPI-1005 Ebselen 200mg Capsule x2;SPI-1005 Ebselen 200mg Capsule x3
33 Asymptomatic Congenital CMV Treatment Not yet recruiting NCT03301415 Phase 2 Valganciclovir
34 Autologous Bone Marrow Harvest and Transplant for Sensorineural Hearing Loss Suspended NCT02616172 Phase 1, Phase 2
35 Safety of Autologous Stem Cell Infusion for Children With Acquired Hearing Loss Suspended NCT02038972 Phase 1, Phase 2
36 Study of the Effects of Anakinra in Corticosteroid-resistant Subjects With Sudden Sensorineural Hearing Loss Terminated NCT02414152 Phase 1, Phase 2 anakinra
37 A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss Completed NCT01518920 Phase 1 PF-04958242;PF-04958242;Placebo
38 Wide-Bandwidth Open Canal Hearing Aid For Better Multitalker Speech Understanding Completed NCT00582946 Phase 1
39 Study to Determine the Safety, Tolerability, and Pharmacokinetic Profile of HPN-07 and HPN-07 Plus NAC Completed NCT02259595 Phase 1 HPN-07;NAC;Placebo
40 Triamcinolone Levels in Cochlear Perilymph Not yet recruiting NCT03248856 Phase 1 Triamcinolone Acetonide
41 Fludrocortisone for Sudden Hearing Loss Unknown status NCT01186185 Fludrocortisone
42 Middle-Ear Implant With MET V Transducer (Aka MET V System) Unknown status NCT01529333
43 Clinical Applications of Round Window Imaging Anatomy in Cochlear Implant Surgery Unknown status NCT02093806
44 Balance Control and Maturation in Normal and Deaf Children Aged From 6 to 14 Years Old Unknown status NCT00140699
45 Objective Measures in Implantable Hearing Devices Unknown status NCT01780025
46 Study of Low Level Laser Therapy and Word Recognition in Hearing Impaired Individuals Completed NCT00787189
47 Central Auditory Processing and the Use of Hearing Aids Completed NCT01897181
48 Nucleus Freedom Cochlear Implant System Pediatric Post-approval Study Completed NCT00589511
49 Evaluation of the Nucleus Hybrid™ L24 Cochlear Implant System Completed NCT00678899
50 The Effect of Sound Stimulation on Hearing Ability Completed NCT01434446

Search NIH Clinical Center for Sensorineural Hearing Loss

Cochrane evidence based reviews: hearing loss, central

Genetic Tests for Sensorineural Hearing Loss

Genetic tests related to Sensorineural Hearing Loss:

id Genetic test Affiliating Genes
1 Sensorineural Hearing Loss 29

Anatomical Context for Sensorineural Hearing Loss

MalaCards organs/tissues related to Sensorineural Hearing Loss:

39
Bone, Testes, Brain, Bone Marrow, Endothelial, Neutrophil, Heart

Publications for Sensorineural Hearing Loss

Articles related to Sensorineural Hearing Loss:

(show top 50) (show all 1001)
id Title Authors Year
1
Intratympanic steroid delivery by an indwelling catheter in refractory severe sudden sensorineural hearing loss. ( 28511890 )
2017
2
Hyperbaric Oxygen Therapy as Adjuvant Treatment for Idiopathic Sudden Sensorineural Hearing Loss after Failure of Systemic Steroids. ( 28423374 )
2017
3
Adjunctive hyperbaric oxygen treatment for idiopathic sudden sensorineural hearing loss. ( 28768087 )
2017
4
Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis. ( 28648633 )
2017
5
Questionnaires in Patients with Unilateral Sudden Sensorineural Hearing Loss. ( 28816692 )
2017
6
Degeneration of auditory nerve fibers in guinea pigs with severe sensorineural hearing loss. ( 28087418 )
2017
7
A honey bee can threat ear: Sudden sensorineural hearing loss. ( 28818308 )
2017
8
Resolution of giant basilar artery aneurysm compression and reversal of sensorineural hearing loss with use of a flow diverter: case report. ( 28452658 )
2017
9
The effect of side of implantation on unilateral cochlear implant performance in patients with prelingual and postlingual sensorineural hearing loss - a systematic review. ( 28944603 )
2017
10
Effect of antioxidant supplementation on the auditory threshold in sensorineural hearing loss: a meta-analysis. ( 28888754 )
2017
11
Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss. ( 28460253 )
2017
12
Evaluation of Procalcitonin and hs-CRP Levels in Sudden Sensorineural Hearing Loss. ( 28639554 )
2017
13
Sealing of the round and oval window niches with triamcinolone-soaked fascia as salvage surgical therapy in sudden sensorineural hearing loss. ( 28415914 )
2017
14
Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss. ( 28484279 )
2017
15
Prognostic factors for idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and intravenous steroids. ( 27917721 )
2017
16
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
17
Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss. ( 28946916 )
2017
18
In response to In reference to laboratory assessment of sudden sensorineural hearing loss: A case-control study. ( 28722186 )
2017
19
Cochlear malformation and sensorineural hearing loss in the Silver-Russell syndrome. ( 28882028 )
2017
20
Deep band modulated phrase perception in quiet and noise in individuals with auditory neuropathy spectrum disorder and sensorineural hearing loss. ( 28816204 )
2017
21
Differences in platelet-related parameters among patients with audiographically distinct sudden sensorineural hearing loss: A retrospective study. ( 28885341 )
2017
22
A mild phenotype of sensorineural hearing loss and palmoplantar keratoderma caused by a novel GJB2 dominant mutation. ( 28872160 )
2017
23
Auditory Performance and Electrical Stimulation Measures in Cochlear Implant Recipients With Auditory Neuropathy Compared With Severe to Profound Sensorineural Hearing Loss. ( 28225734 )
2017
24
Assessing Sensorineural Hearing Loss Using Various Transient-Evoked Otoacoustic Emission Stimulus Conditions. ( 28437273 )
2017
25
Sensorineural Hearing Loss in a Patient Affected by Congenital Cytomegalovirus Infection: Is It Useful to Identify Comorbid Pathologies? ( 28794912 )
2017
26
COQ6 Mutations in Children With Steroid-Resistant Focal Segmental Glomerulosclerosis and Sensorineural Hearing Loss. ( 28117207 )
2017
27
A common variant in CLDN14 causes precipitous, prelingual sensorineural hearing loss in multiple families due to founder effect. ( 27838790 )
2017
28
Anisomorphic Cortical Reorganization in Asymmetric Sensorineural Hearing Loss. ( 28515283 )
2017
29
Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms. ( 28087419 )
2017
30
In reference to laboratory assessment of sudden sensorineural hearing loss: A case-control study. ( 28581031 )
2017
31
Long-Term Progression of Sensorineural Hearing Loss and Tinnitus after Combined Intensity-Modulated Radiation Therapy and Cisplatin-Based Chemotherapy for Nasopharyngeal Carcinoma: A Case Report. ( 28878660 )
2017
32
Interrupted Monosyllabic Words: The Effects of Ten Interruption Locations on Recognition Performance by Older Listeners with Sensorineural Hearing Loss. ( 28054913 )
2017
33
Evaluation of cardiovascular risks and recovery of idiopathic sudden sensorineural hearing loss in hospitalised patients: comparison between complete and partial sudden sensorineural hearing loss. ( 28807070 )
2017
34
Framingham Risk Score as a Prognostic Predictor of Sudden Sensorineural Hearing Loss: A Preliminary Study. ( 28397567 )
2017
35
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. ( 28846788 )
2017
36
Biochemical alteration in children with idiopathic nephrotic syndrome associated with an increased risk of sensorineural hearing loss; additional insights in cochlear renal relationship. ( 28483237 )
2017
37
Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss. ( 28487633 )
2017
38
Genetic studies in a patient with X-linked retinoschisis coexisting with developmental delay and sensorineural hearing loss. ( 28574807 )
2017
39
Analysis of archived newborn dried blood spots (DBS) identifies congenital cytomegalovirus as a major cause of unexplained pediatric sensorineural hearing loss. ( 28629849 )
2017
40
Early identification of idiopathic sudden sensorineural hearing loss. ( 28787350 )
2017
41
Aminophylline restores glucocorticoid sensitivity in a guinea pig model of sudden sensorineural hearing loss induced by lipopolysaccharide. ( 28578424 )
2017
42
High prevalence of abnormalities on CT and MR imaging in children with unilateral sensorineural hearing loss irrespective of age or degree of hearing loss. ( 28483233 )
2017
43
An update on drug design strategies to prevent acquired sensorineural hearing loss. ( 28838250 )
2017
44
Two novel LHX3 mutations in patients with combined pituitary hormone deficiency including cervical rigidity and sensorineural hearing loss. ( 28302169 )
2017
45
Early identification of idiopathic sudden sensorineural hearing loss. ( 28953167 )
2017
46
Cytokine gene polymorphism associations with congenital cytomegalovirus infection and sensorineural hearing loss. ( 28501927 )
2017
47
Prognostic Factors for Recovery from Sudden Sensorineural Hearing Loss: A Retrospective Study. ( 28417102 )
2017
48
Sudden sensorineural hearing loss in children and adolescents: Clinical characteristics and age-related prognosis. ( 28888426 )
2017
49
First report of prevalence c.IVS1+1G>A and del (GJB6-13S1854) mutations in Syrian families with non-syndromic sensorineural hearing loss. ( 28012540 )
2017
50
Comparative Analysis of the Combined Therapeutic Effects of Lipoprostaglandin E1 on Sudden Idiopathic Sensorineural Hearing Loss. ( 28417106 )
2017

Variations for Sensorineural Hearing Loss

Copy number variations for Sensorineural Hearing Loss from CNVD:

7 (show all 13)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 115500 17 58121080 60118579 Deletion Sensorineural hearing loss
2 115503 17 58121080 60118579 Deletion APPBP2 sensorineural hearing loss
3 115507 17 58121080 60118579 Deletion BCAS3 sensorineural hearing loss
4 115511 17 58121080 60118579 Deletion BRIP1 sensorineural hearing loss
5 115515 17 58121080 60118579 Deletion CA4 sensorineural hearing loss
6 115519 17 58121080 60118579 Deletion INTS2 sensorineural hearing loss
7 115523 17 58121080 60118579 Deletion MED13 sensorineural hearing loss
8 115527 17 58121080 60118579 Deletion NACA2 sensorineural hearing loss
9 115531 17 58121080 60118579 Deletion PPM1D sensorineural hearing loss
10 115535 17 58121080 60118579 Deletion TBX2 sensorineural hearing loss
11 115539 17 58121080 60118579 Deletion TBX4 sensorineural hearing loss
12 115543 17 58121080 60118579 Deletion USP32 sensorineural hearing loss
13 115552 17 58172730 60315273 Deletion Sensorineural hearing loss

Expression for Sensorineural Hearing Loss

Search GEO for disease gene expression data for Sensorineural Hearing Loss.

Pathways for Sensorineural Hearing Loss

Pathways related to Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.14 COL2A1 DLX5 MITF
2
Show member pathways
10.92 GJB2 GJB3 GJB6 MYO6

GO Terms for Sensorineural Hearing Loss

Cellular components related to Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.62 ATP6V1B1 GJB6 MYO7A SLC26A4
2 microvillus GO:0005902 9.43 ATP6V1B1 MYO6 MYO7A
3 myosin complex GO:0016459 9.33 MYH9 MYO6 MYO7A
4 gap junction GO:0005921 9.13 GJB2 GJB3 GJB6
5 connexin complex GO:0005922 8.8 GJB2 GJB3 GJB6

Biological processes related to Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.67 COL2A1 EYA4 MYO7A WFS1
2 ossification GO:0001503 9.58 ATP6V1B1 COL2A1 DLX5
3 inner ear morphogenesis GO:0042472 9.55 ATP6V1B1 COL2A1 DLX5 KCNQ4 MYO7A
4 cell communication GO:0007154 9.5 GJB2 GJB3 GJB6
5 sensory perception of sound GO:0007605 9.47 ATP6V1B1 COCH COL2A1 EYA4 GJB2 GJB6
6 regulation of pH GO:0006885 9.43 ATP6V1B1 SLC26A4
7 actin filament-based movement GO:0030048 9.43 MYH9 MYO6 MYO7A
8 inner ear development GO:0048839 9.35 COL2A1 EYA4 GJB2 GJB6 MYO7A

Molecular functions related to Sensorineural Hearing Loss according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 motor activity GO:0003774 9.5 MYH9 MYO6 MYO7A
2 microfilament motor activity GO:0000146 9.37 MYH9 MYO7A
3 gap junction channel activity GO:0005243 9.26 GJB2 GJB3
4 calmodulin binding GO:0005516 9.26 MYH9 MYO6 MYO7A WFS1
5 actin-dependent ATPase activity GO:0030898 9.16 MYH9 MYO7A
6 ADP binding GO:0043531 8.8 MYH9 MYO6 MYO7A

Sources for Sensorineural Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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