Sensorineural Hearing Loss malady

Wikipedia: Sensorineural hearing loss (SNHL) is a type of hearing loss in which the root cause lies in the...⁴⁴ more...

MalaCards: Sensorineural Hearing Loss, also known as deafness, is related to pendred syndrome and congenital cytomegalovirus. An important gene associated with Sensorineural Hearing Loss is MCDR4 (macular dystrophy, retinal, 4 (North Carolina type with progressive sensorineural hearing loss)), and among its related pathways are Transendothelial Migration of Leukocytes and Rho Family GTPases. The compounds serine and copper have been mentioned in the context of this disorder. Affiliated tissues include brain and t cells, and related mouse phenotypes are hearing/vestibular/ear and behavior/neurological.

Aliases & Descriptions:

sensorineural hearing loss 6 8 deafness 6 7 43 sensory hearing loss 6 32 sensorineural hearing loss (disorder) 43 hearing loss, high-frequency 43 high-frequency hearing loss 6 hearing loss high-frequency 32 high frequency hearing loss 6 hearing loss sensorineural 32

high frequency deafness 6 perceptive hearing loss 6 sensorineural deafness 6 deafness sensorineural 32 hearing loss, central 43 complete hearing loss 43 central hearing loss 6 perceptive deafness 6

Diseases related to sensorineural hearing loss by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1021)

id	Related Disease	Score	Top Affiliating Genes
1	pendred syndrome	32.9	PAX3, MITF, GJB2, COL4A5, SLC26A4, SLC26A5
2	congenital cytomegalovirus	32.5	MT-RNR1, GJB2, GJB6
3	kid syndrome	31.2	GJB2, GJB3, GJB6
4	optic atrophy	31.1	MT-ND5, MT-ND6, PDE5A, PRPS1, OPA1, WFS1
5	enlarged vestibular aqueduct	31.1	MYO15A, KCNJ10, ATP6V0A4, GJB2, GJB3, GJB6
6	macrothrombocytopenia	30.9	ITGB3, GJB2, GJB3, MYH9
7	dfnb1	30.8	PCDH15, MYO7A, GJB2, GJB6, OTOF
8	congenital deafness with labyrinthine aplasia, microtia, and microdontia	30.1	MYO15A, MYO7A, GJB2, GJB6, TMPRSS3, SLC26A4
9	congenital cataracts	29.9	ATP7A, ATP7B, COL4A5, SOD1, CP
10	cytomegalovirus infection	29.8	MTHFR, MT-RNR1, APOE, F5, GJB2, GJB6
11	usher syndrome	29.7	COCH, PCDH15, MYO15A, MYO7A, USH1C, USH2A
12	ataxia	29.5	LRP2, SERPINE1, USH1C, USH2A, BCS1L, KCNJ10
13	nonsyndromic hearing loss and deafness	29.2	MT-TS1, MT-RNR1, GJB2, GJB6
14	autosomal dominant nonsyndromic deafness	28.7	CEACAM16, TECTA, SLC17A8
15	skin disease	28.4	BDNF, MITF, FGFR3, IL1A, GJB2, GJB3
16	otitis media	28.4	SERPINC1, SERPINE1, IL1A, F5, EYA4, TNF
17	amyloidosis	28.4	SERPINC1, GSN, FGFR3, APOE, F5, HLA-DRB1
18	antiphospholipid syndrome	28.3	SERPINC1, SERPINE1, MTHFR, ITGB3, APOH, F5
19	nonsyndromic deafness	28.0	COCH, PCDH15, MYO6, MYO15A, MYO1A, MYO3A
20	cerebrovascular disease	27.9	SERPINC1, SERPINE1, MTHFR, MTR, ITGB3, GSTM1
21	usher syndrome, type 1f	27.8	COCH, PCDH15, MYO7A, USH1C
22	usher syndrome type i	27.6	PCDH15, MYO7A, USH1C, CDH23
23	cataract	27.4	MTHFR, ATP7A, ATP7B, GSTM1, GSTT1, IL1A
24	homocysteine	26.8	SERPINC1, SERPINE1, MTHFR, MTR, ITGB3, GSTM1
25	usher syndrome, type 1d	26.3	PCDH15, USH1C, CDH23
26	osteoarthritis	26.2	SERPINE1, ITGB3, GSTM1, GSTT1, IL1A, ESRRB
27	auditory neuropathy	26.1	GJB2, GJB6, DIAPH3, OTOF
28	hearing loss	25.9	LRP2, COCH, RDX, PCDH15, SERPINC1, SERPINB6
29	ectodermal dysplasia	25.7	FGFR3, GJB2, GJB3, GJB6, TNF, TNFRSF1A
30	hypogonadism	25.7	SERPINC1, SERPINE1, LHX3, F5, ESRRB, TNF
31	mental retardation syndrome	25.6	RDX, BDNF, MTR, ATP7A, FGFR3, HOXA1
32	usher syndrome type 3	25.6	PCDH15, MYO7A, USH1C, USH2A, CDH23, GPR98
33	peripheral neuropathy	25.4	BDNF, MTHFR, MTR, ITGB3, GSN, GSTM1
34	infertility	25.2	SERPINE1, BDNF, MTHFR, MTR, ITGB3, GSTM1
35	anemia	25.1	SERPINC1, BCS1L, MT-CO1, MTHFR, MT-ATP6, MTR
36	seizures	25.0	BDNF, KCNJ10, MT-ND5, MT-CO1, MTHFR, MT-ATP6
37	mitochondrial encephalomyopathy	24.9	BCS1L, MT-ND5, MT-TL1, MT-CO1, MT-ATP6, MT-ND6
38	encephalomyopathy	24.8	BCS1L, MT-ND5, MT-TL1, MT-CO1, MT-ATP6, MT-ND6
39	cholesterol	24.7	LRP2, SERPINC1, SERPINE1, BDNF, MTHFR, ITGB3
40	major depressive disorder	24.5	SERPINE1, BDNF, MTHFR, APOE, TNF, NOS1
41	congenital heart defect	24.3	SERPINC1, SERPINE1, MTHFR, F3, F2, TNF
42	immunodeficiency	23.9	RDX, SERPINC1, SERPINE1, BDNF, SDHD, ITGB3
43	atopy	23.9	MTHFR, GSTM1, GSTT1, IL1A, GJB2, HLA-DRB1
44	polyneuropathy	23.8	MT-TL1, GSN, GSTM1, GSTT1, APOE, HLA-DRB1
45	hypothyroidism	23.4	LRP2, SERPINC1, SERPINE1, LHX3, APOE, F3
46	insulin resistance	22.8	SERPINE1, BDNF, MTHFR, MTR, APOE, APOH
47	myopathy	22.8	PAX3, BDNF, MT-ND5, MT-TS1, MT-TL1, MT-CO1
48	neuronitis	21.9	LRP2, RDX, PCDH15, SERPINC1, SERPINE1, MYO6
49	blindness	21.4	PCDH15, SERPINC1, SERPINE1, MYO7A, USH1C, USH2A
50	nephropathy	20.9	LRP2, SERPINE1, MTHFR, MTR, SALL1, XPNPEP3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to sensorineural hearing loss:

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MGI Mouse Phenotypes related to sensorineural hearing loss:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	INF	COCH, , STRC, DFNB31, DFNA5,
2	behavior/neurological phenotype	MP:0005386	INF	CP, , SLC26A4, PMP22, , POU3F4
3	vision/eye phenotype	MP:0005391	INF	CP, APOE, , , MITF, ITGB3
4	digestive/alimentary phenotype	MP:0005381	INF	, HLA-DQB1, TNF, TNFRSF1A, DLX5, NOS1
5	cardiovascular system phenotype	MP:0005385	INF	COL2A1, COL4A5, NOS1, DLX5, TNFRSF1A, TNF
6	homeostasis/metabolism phenotype	MP:0005376	INF	, TNFRSF1A, TNF, HLA-DQB1, GJB6, GJB3
7	mortality/aging	MP:0010768	INF	COL4A5, NOS1, DLX5, TNFRSF1A, HLA-DQB1,
8	cellular phenotype	MP:0005384	INF	G6PD, EGFR, LTA, NOS1, ,
9	skeleton phenotype	MP:0005390	INF	TNFRSF1A, , NOS1, , COL2A1, EGFR
10	muscle phenotype	MP:0005369	INF	DLX5, NOS1, EGFR, , TWIST1, OPA1
11	normal phenotype	MP:0002873	INF	HOXA1, HLA-DQB1, DLX5, , NOS1, COL2A1
12	integument phenotype	MP:0010771	INF	GJB2, GJB3, TNFRSF1A, DLX5, , NGF
13	embryogenesis phenotype	MP:0005380	INF	TNFRSF1A, DLX5, COL2A1, EGFR, G6PD, TWIST1
14	pigmentation phenotype	MP:0001186	8.9	CP, SLC26A4, SOX2, EGFR, APOE, MITF
15	reproductive system phenotype	MP:0005389	INF	TNF, TNFRSF1A, DFNB31, OPA1, SOX2,
16	liver/biliary system phenotype	MP:0005370	INF	SOD1, DFNB31, EGFR, COL2A1, ATP7B, ATP7A
17	respiratory system phenotype	MP:0005388	INF	COL2A1, NOS1, DLX5, APOE, GSN, ITGB3
18	immune system phenotype	MP:0005387	INF	TNFRSF1A, , NOS1, COL4A5, COL2A1, EGFR
19	endocrine/exocrine gland phenotype	MP:0005379	INF	LTA, DFNB31, OPA1, SLC26A4, WFS1, HOXA1
20	limbs/digits/tail phenotype	MP:0005371	INF	TNF, TNFRSF1A, DLX5, COL2A1, LTA, EGFR
21	growth/size phenotype	MP:0005378	INF	ITGB3, , ATP7B, ATP7A, , MTHFR
22	nervous system phenotype	MP:0003631	INF	NGF, COL2A1, NOS1, OTOF, DLX5,
23	renal/urinary system phenotype	MP:0005367	INF	COL2A1, EGFR, DFNB31, SLC26A4, MYH9, COL4A5
24	craniofacial phenotype	MP:0005382	INF	, , COL2A1, TWIST1, OPA1, POU3F4
25	no phenotypic analysis	MP:0003012	INF	GJB2, GJB3, , , OTOF, EGFR
26	hematopoietic system phenotype	MP:0005397	INF	, SLC29A3, DFNB31, , HLA-DQB1, HOXA1

Articles related to sensorineural hearing loss:

(show top 50)    (show all 134)

id	Title	Authors	Year	Affiliating Genes
1	Low prevalence of DFNB1 (connexin 26) mutations in Br itish Pakistani children with non-syndromic sensorineural hearing loss. (21586435)	Yoong S.Y.... Spencer N.	2011	GJB2
2	Molecular epidemiological analysis of mitochondrial D NA12SrRNA A1555G, GJB2, and SLC26A4 mutations in sporadic outpatients with nons yndromic sensorineural hearing loss in China. (21162657)	Ji Y.B.... Wang Q.J.	2011	GJB2, SLC26A4
3	Mutations in mitochondrial histidyl tRNA synthetase H ARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndro me. (21464306)	Pierce S.B.... King M.C.	2011	HARS2
4	Progressive sensorineural hearing loss and normal ves tibular function in a Dutch DFNB7/11 family with a novel mutation in TMC1. (21252500)	de Heer A.M.... Cremers C.W.	2011	TMC1
5	Gipc3 mutations associated with audiogenic seizures a nd sensorineural hearing loss in mouse and human. (21326233)	Charizopoulou N.... Noben-Trauth K.	2011	GIPC3
6	GJB2 mutations and genotype-phenotype correlation in 335 patients from germany with nonsyndromic sensorineural hearing loss: evidenc e for additional recessive mutations not detected by current methods. (20234132)	Bartsch O.... Keilmann A.	2010	GJB2
7	Sequencing analysis of whole SLC26A4 gene in severe to profound sensorineural hearing loss patients with IVS7-2A to G mutation of t he gene]. (21154317)	Li Q.... Dai P.	2010	SLC26A4
8	A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. (20451170)	Sirmaci A.... Tekin M.	2010	SERPINB6
9	Early-onset sensorineural hearing loss is a prominent feature of H syndrome. (20399510)	Ramot Y.... Zlotogorski A.	2010	SLC29A3
10	Identification of a novel mutation in the SLC26A4 gen e in an Italian with fluctuating sensorineural hearing loss. (19615760)	Cama E.... Melchionda S.	2009	SLC26A4
11	The A1555G mitochondrial DNA mutation in Greek patien ts with non-syndromic, sensorineural hearing loss. (19835846)	Kokotas H.... Petersen M.B.	2009	MT-RNR1
12	Relative contributions of radiation and cisplatin-bas ed chemotherapy to sensorineural hearing loss in head-and-neck cancer patients. (18707819)	Hitchcock Y.J.... Shrieve D.C.	2009	EGFR
13	Candidate Genes of Cerebrovascular Disease and Sudden Sensorineural Hearing Loss. (19833626)	Um J.Y.... Kim H.M.	2009	TNF, LTA
14	KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss. (18797286)	Nie L.	2008	KCNQ4
15	Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. (18407919)	Rajab A.... Dattani M.T.	2008	SOX2, LHX3
16	Mutations at position 7445 in the precursor of mitochondrial tRNA(Ser(UCN)) gene in three maternal Chinese pedigrees with sensorineural hearing loss. (18639500)	Chen J.... Guan M.X.	2008	MT-ND6
17	Novel approaches to treating sensorineural hearing loss. Auditory genetics and necessary factors for stem cell transplant. (18668008)	Vlastarakos P.V.... Ferekidis E.	2008	ATOH1
18	A novel WFS1 mutation in a family with dominant low frequency sensorineural hearing loss with normal VEMP and EcochG findings. (18518985)	Bramhall N.F.... Street V.A.	2008	WFS1
19	Haplogroup analysis supports a pathogenic role for the 7510T>C mutation of mitochondrial tRNA(Ser(UCN)) in sensorineural hearing loss. (18028453)	Labay V.... Griffith A.J.	2008	MT-TS1
20	Comparison of immune assays for the detection of anti-HSP70 antibodies in patients with idiopathic sensorineural hearing loss. (17434470)	Tebo A.E.... Hill H.R.	2007	HSPA8
21	Etanercept, a tumour necrosis factor alpha receptor a ntagonist, and methotrexate in acute sensorineural hearing loss. (17040588)	Street I.... Proops D.W.	2006	TNF, TNFRSF1A
22	Pseudodominants of two recessive connexin mutations in non-syndromic sensorineural hearing loss? (16547895)	Birkenhager R.... Schipper J.	2006	GJB3, GJB6
23	Glutathione s-transferase gene polymorphisms in Italian patients with sudden sensorineural hearing loss. (16788422)	Cadoni G.... Agostino S.	2006	GSTT1, GSTM1
24	Increased frequencies of cochlin-specific T cells in patients with autoimmune sensorineural hearing loss. (16951386)	Baek M.J.... Tuohy V.K.	2006	COCH
25	Effect of nitric oxide and nitric oxide synthase on sensorineural hearing loss secondary to secretory otitis media (16981472)	Chen F.... Gao X.	2006	NOS1
26	Congenital cataract, muscular hypotonia, developmental delay and sensorineural hearing loss associated with a defect in copper metabolism. (15902551)	HorvA!th R.... Jaksch M.	2005	SOD1, CP, ATP7A
27	Sudden sensorineural hearing loss in lupus erythemato sus associated with antiphospholipid syndrome: case report and review. (15825571)	Compadretti G.C.... Tasca I.	2005	APOH
28	Dominant optic atrophy, sensorineural hearing loss, ptosis, and ophthalmoplegia: a syndrome caused by a missense mutation in OPA1. (15531309)	Payne M.... Zhang K.	2004	OPA1
29	A diagnostic paradigm for childhood idiopathic sensorineural hearing loss. (15577772)	Preciado D.A.... Greinwald J.H.	2004	GJB2
30	Childhood-onset osteoarthritis, tall stature, and sensorineural hearing loss associated with Arg75-Cys mutation in procollagen type II gene (COL2A1). (15593085)	Lopponen T.... Kaariainen H.	2004	COL2A1
31	Evaluation of a family with sensorineural hearing loss due to the Q829X mutation in the OTOF gene (15253338)	Gallo-Teran J.... Moreno Herrero F.	2004	OTOF
32	Nerve growth factor and brain-derived neurotrophic factor: a possible etiopathogenic role in sensorineural hearing loss. Preliminary data (14587217)	Salvinelli F.... Aloe L.	2003	BDNF, NGF
33	Mutations in the Wolfram syndrome type 1 gene (WFS1) define a clinical entity of dominant low-frequency sensorineural hearing loss. (12707187)	Lesperance M.M.... Leal S.M.	2003	WFS1
34	Progressive late-onset sensorineural hearing loss and vestibular impairment with vertigo (DFNA9/COCH): longitudinal analyses in a belgian family. (14501450)	Lemaire F.X.... Koss J.C.	2003	COCH
35	Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss. (12736868)	Donaudy F.... Gasparini P.	2003	MYO1A
36	A PCR-RFLP assay for the A716T mutation in the WFS1 gene, a common cause of low-frequency sensorineural hearing loss. (12490066)	Sivakumaran T.A.... Lesperance M.M.	2002	WFS1
37	GJB2 (connexin 26) variants and nonsyndromic sensorineural hearing loss: a HuGE review. (12172392)	Kenneson A.... Boyle C.	2002	GJB2, GJB6
38	A child with Saethre-Chotzen syndrome, sensorineural hearing loss, and a TWIST mutation. (11772178)	Lee S.... Cunningham M.	2002	TWIST1
39	GJB2 mutations in Iranians with autosomal recessive non-syndromic sensorineural hearing loss. (11968091)	Najmabadi H.... Smith R.J.	2002	GJB2
40	Confirmation of genetic homogeneity of nonsyndromic low-frequency sensorineural hearing loss by linkage analysis and a DFNA6/14 mutation in a Japanese family. (12181639)	Komatsu K.... Yoshiura K.	2002	WFS1
41	Sensorineural hearing loss and the incidence of Cx26 mutations in Austria. (11313763)	Loffler J.... Janecke A.R.	2001	GJB2
42	Connexin 26 studies in patients with sensorineural hearing loss. (11556849)	Kenna M.A.... Rehm H.L.	2001	GJB2
43	Fluctuating sensorineural hearing loss associated with enlarged vestibular aqueduct maps to 7q31, the region containing the Pendred gene. (10051166)	Abe S.... Kimberling W.J.	1999	SLC26A4
44	Autosomal-dominant, prelingual, nonprogressive sensorineural hearing loss: localization of the gene (DFNA8) to chromosome 11q by linkage in an Austrian family. (9763681)	Kirschhofer K.... Kimberling W.J.	1998	TECTA
45	Molecular analysis of the PDS gene in Pendred syndrome (sensorineural hearing loss and goitre). (9618167)	Coyle B.... Trembath R.C.	1998	SLC26A4
46	A gene for non-syndromic autosomal dominant progressive postlingual sensorineural hearing loss maps to chromosome 14q12-13. (8817345)	Manolis E.N.... Seidman J.G.	1996	COCH
47	Delayed development of sensorineural hearing loss after neonatal hyperbilirubinemia: a case report with brain magnetic resonance imaging. (8631524)	Worley G.... Ware R.E.	1996	G6PD
48	Dejerine-Sottas disease with sensorineural hearing loss, nystagmus, and peripheral facial nerve weakness: de novo dominant point mutation of the PMP22 gene. (9004143)	Ionasescu V.V.... Greenberg S.A.	1996	PMP22
49	Serum antibodies to heat shock protein 70 in sensorineural hearing loss. (7546586)	Bloch D.B.... Bloch K.J.	1995	HSPA8
50	Autosomal dominant sensorineural hearing loss. Pedigrees, audiologic findings, and temporal bone findings in two kindreds. (1910721)	Khetarpal U.... Holmes L.B.	1991	COCH

Genes related to sensorineural hearing loss according to GeneCards:

(show top 50)    (show all 86)

id	Symbol	Description	Score	GeneCards Section Context
1	MCDR4	macular dystrophy, retinal, 4 (North Carolina type with progressive sensorineural hearing loss)	11.1	Aliases & Descriptions, Publications
2	SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6	11.1	Publications, Summaries, Functions
3	DLX5	distal-less homeobox 5	11.0	Aliases & Descriptions
4	DFNB20	deafness, autosomal recessive 20	11.0	Publications
5	DFNA52	deafness, autosomal dominant 52	11.0	Publications
6	MT-RNR1	mitochondrially encoded 12S RNA	11.0	Publications
7	MT-TS1	mitochondrially encoded tRNA serine 1 (UCN)	11.0	Publications
8	RNR1	RNA, ribosomal 1	11.0	Publications
9	COCH	coagulation factor C homolog, cochlin (Limulus polyphemus)	11.0	Publications
10	MT-TL1	mitochondrially encoded tRNA leucine 1 (UUA/G)	11.0	Publications
11	TMIE	transmembrane inner ear	11.0	Publications
12	STRC	stereocilin	11.0	Publications
13	GJB3	gap junction protein, beta 3, 31kDa	11.0	Publications
14	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications
15	GIPC3	GIPC PDZ domain containing family, member 3	11.0	Publications
16	BCS1L	BCS1-like (S. cerevisiae)	11.0	Publications
17	SLC26A4	solute carrier family 26, member 4	11.0	Publications
18	WFS1	Wolfram syndrome 1 (wolframin)	11.0	Publications
19	KCNQ4	potassium voltage-gated channel, KQT-like subfamily, member 4	11.0	Publications
20	ATOH1	atonal homolog 1 (Drosophila)	11.0	Publications
21	NUPL2	nucleoporin like 2	11.0	Publications
22	POU3F4	POU class 3 homeobox 4	11.0	Publications
23	TECTB	tectorin beta	11.0	Publications
24	HARS2	histidyl-tRNA synthetase 2, mitochondrial	11.0	Publications
25	LHX3	LIM homeobox 3	11.0	Publications
26	GJB6	gap junction protein, beta 6, 30kDa	11.0	Publications
27	MYO1A	myosin IA	11.0	Publications
28	MT-ATP6	mitochondrially encoded ATP synthase 6	11.0	Publications
29	HOXA1	homeobox A1	11.0	Publications
30	MTO1	mitochondrial translation optimization 1 homolog (S. cerevisiae)	11.0	Publications
31	OTOF	otoferlin	11.0	Publications
32	ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	11.0	Publications
33	SOX2	SRY (sex determining region Y)-box 2	11.0	Publications
34	MYO7A	myosin VIIA	11.0	Publications
35	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0	Publications
36	PMP22	peripheral myelin protein 22	11.0	Publications
37	TECTA	tectorin alpha	11.0	Publications
38	DFNB31	deafness, autosomal recessive 31	11.0	Publications
39	DFNA5	deafness, autosomal dominant 5	11.0	Publications
40	EYA4	eyes absent homolog 4 (Drosophila)	11.0	Publications
41	TWIST1	twist homolog 1 (Drosophila)	11.0	Publications
42	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
43	COL2A1	collagen, type II, alpha 1	11.0	Publications
44	HSPA8	heat shock 70kDa protein 8	11.0	Publications
45	TMC1	transmembrane channel-like 1	11.0	Publications
46	ATP6V0A4	ATPase, H+ transporting, lysosomal V0 subunit a4	11.0	Publications
47	MYO6	myosin VI	11.0	Publications
48	OPA1	optic atrophy 1 (autosomal dominant)	11.0	Publications
49	ATP7A	ATPase, Cu++ transporting, alpha polypeptide	11.0	Publications
50	PAX3	paired box 3	11.0	Publications

Pathways related to sensorineural hearing loss according to GeneDecks:

(show all 32)

id	Pathway	Score	Top Affiliating Genes
1	Transendothelial Migration of Leukocytes36	INF	, , COL4A5, , COL2A1,
2	Rho Family GTPases36	INF	COL4A5, , COL2A1, LTA, ,
3	Apoptotic Pathways in Synovial Fibroblasts36	INF	, EGFR, LTA, TNFRSF1A, TNF,
4	Blood Coagulation Cascade36	INF	COL2A1, , COL4A5, , F2, F3
5	Epithelial Tight Junctions36	INF	MYH9, , TNFRSF1A, TNF, ITGB3,
6	Actin Nucleation by ARP-WASP Complex36	INF	MYH9, , EGFR, , ITGB3, MYO7A
7	Intrinsic Prothrombin Activation Pathway36	INF	COL2A1, , COL4A5, , F2, F5
8	NF-KappaB Family Pathway36	INF	, EGFR, LTA, TNFRSF1A, TNF, IL1A
9	RhoA Pathway36	INF	MYH9, , ITGB3, MYO7A, , MYO1A
10	Focal adhesion20	INF	, , EGFR, COL2A1, COL4A5,
11	CDC42 Pathway36	INF	, EGFR, , , HLA-DRB1, HLA-DQB1
12	NF-KappaB (p50-p65) Pathway36	INF	, EGFR, LTA, TNFRSF1A, TNF, IL1A
13	ILK Signaling36	INF	MYO6, , COL4A5, , COL2A1, EGFR
14	MAPK Signaling36	INF	, COL2A1, LTA, EGFR, , COL4A5
15	Extrinsic Prothrombin Activation Pathway36	10.1	F2, F3, F5, SERPINC1
16	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	10.0	SOD1, GSTT1, GSTM1, ATP7B, ATP7A
17	Blood Coagulation Signaling Pathways37	9.7	F2, F3, F5, SERPINE1, SERPINC1
18	Type I diabetes mellitus20	9.5	LTA, TNF, HLA-DRB1, HLA-DQB1, IL1A
19	Rheumatoid arthritis20	9.4	TNF, HLA-DRB1, HLA-DQB1, IL1A, ATP6V0A4, ATP6V1B1
20	Immune response IL-1 signaling pathway10	9.0	CP, TNF, F3, IL1A, SERPINE1
21	Immune response_IL-1 signaling pathway41	8.7	CP, TNF, F3, IL1A, SERPINE1
22	PTEN Pathway36	INF	, , EGFR, , COL4A5,
23	PAK Pathway36	INF	TNF, LTA, EGFR, , , MYH9
24	Fc-GammaR-Mediated Phagocytosis in Macrophages36	INF	MYH9, , GSN, MYO7A, , MYO1A
25	Oxidative phosphorylation20	INF	ATP6V0A4, ATP6V1B1, MT-ND6, MT-ATP6, , MT-ND5
26	Regulation of actin cytoskeleton20	INF	MYH9, , EGFR, , ,
27	RhoGDI Pathway36	INF	MYH9, EGFR, , MYO7A, , MYO1A
28	Antioxidant Action of Vitamin-C36	INF	TNFRSF1A, LTA, EGFR, , , MYH9
29	Epithelial Adherens Junctions36	INF	MYH9, , , EGFR, , MYO7A
30	PPAR Pathway36	INF	EGFR, LTA, TNFRSF1A, TNF, , ITGB3
31	Cellular Effects of Sildenafil36	INF	MYH9, , PDE5A, NOS1, MYO7A,
32	Phagosome20	INF	ATP6V1B1, ATP6V0A4, ITGB3, HLA-DQB1, HLA-DRB1, NOS1

Compounds related to sensorineural hearing loss according to GeneDecks:

(show top 50)    (show all 119)

id	Compound	Score	Top Affiliating Genes
1	serine32	INF	MTHFR, MTR, ATP7A, ITGB3, , IL1A
2	copper32 18	INF	APOH, , ATP7B, MTR, ATP7A, F5
3	calcium32 9 18 9	INF	, , , COL2A1, NOS1, ATP6V0A4
4	oxygen32 18	INF	HSPA8, MYO1A, BDNF, SDHD, ,
5	folate32	INF	, MTR, PDE5A, CP, SERPINC1, MTHFR
6	n acetylcysteine32	INF	EGFR, SERPINC1, BDNF, APOE, F2,
7	cycloheximide32	INF	SERPINE1, PAX3, , DLX5, TNFRSF1A, TNF
8	atp32	INF	HSPA8, , ATP7B, ITGB3, GSN, G6PD
9	superoxide32 18	INF	SOD1, , CP, MTR, TNFRSF1A, HSPA8
10	arginine32	INF	NOS1, HLA-DRB1, COL2A1, NGF, PDE5A, SOD1
11	vegf32	INF	IL1A, , ITGB3, BDNF, SERPINE1, SERPINC1
12	vitamin d32	INF	HSPA8, CP, SERPINE1, LTA, NGF, COL2A1
13	glutamine32	INF	, NGF, PDE5A, G6PD, CP,
14	heparin32 9 18 9	INF	GSN, F2, , , CP, SERPINE1
15	vitamin-e32	INF	G6PD, SOD1, CP, , F5,
16	cyclophosphamide32 34 9 9	13.5	APOH
17	inogatran32	10.2	F2, F3, F5, SERPINC1
18	ecarin32	10.1	F5, F3, SERPINC1, F2
19	spectrozyme32	10.0	F3, F2, SERPINC1, F5
20	Drotrecogin alfa9 9	11.0	CP, F5, SERPINE1, SERPINB6, F2
21	danaparoid32	9.9	SERPINC1, F5, F2, F3
22	warfarin32 34 9 18 9	13.4	F3, F5, SERPINC1, MTHFR, APOE, APOH
23	ascorbic acid32 18	10.4	G6PD, BDNF, GSTT1, IL1A, NOS1, COL2A1
24	homocysteine32 18	10.0	MTHFR, MTR, APOE, APOH, F3, F5
25	betacarotene32	8.8	MTHFR, SOD1, EGFR, CP, APOH, APOE
26	manganese superoxide32	8.7	GSTT1, GSTM1, SOD1, IL1A, HSPA8, TNF
27	endotoxin32	8.7	IL1A, APOH, GSN, SERPINE1, TNF, HSPA8
28	alpha tocopherol32	8.7	APOE, GSTM1, G6PD, MTHFR, APOH, SOD1
29	simvastatin32 34 42 9 18 9	13.5	F5, IL1A, APOE, SERPINE1, F3, F2
30	valine32	7.3	MTHFR, MTR, MT-ND6, GSTM1, GSTT1, APOE
31	vitamin b1232	INF	MTHFR, , F5, MTR, APOE, APOH
32	hepaplastin32	INF
33	retinoic acid32 42 18	INF	NGF, GSN, , TNFRSF1A, , TNF
34	aprotinin32 9 9	INF	F2, , SERPINC1, IL1A, F5
35	glutamate32	INF	MTR, MTHFR, MITF, GSN, HSPA8,
36	lipid32	INF	, , , COL2A1, LTA, G6PD
37	pdtc32	INF	NGF, SOD1, IL1A, F3, TNF, NOS1
38	malondialdehyde32	INF	GSTT1, GSTM1, APOH, F5, COL2A1, G6PD
39	aspirin32 34 18	INF	NGF, , F2, F3, F5, SERPINE1
40	uric acid32 18	INF	APOH, CP, SOD1, MTHFR, F5, SERPINE1
41	creatinine32	INF	, CP, SOD1, MTHFR, SERPINC1, BDNF
42	formate32	INF	SLC26A4, SOD1, G6PD, APOE, MTR,
43	alanine32	INF	F3, COL2A1, , NGF, SERPINC1, GSN
44	estrogen32	INF	GSTT1, APOE, APOH, F5, HSPA8,
45	cysteine32	INF	PMP22, TNFRSF1A, COCH, PAX3, NOS1, COL2A1
46	prostacyclin32	INF	, SOD1, PDE5A, NGF, SERPINC1, SERPINE1
47	testosterone32 9 18 9	INF	NGF, PDE5A, EGFR, G6PD, CP,
48	indomethacin32 9 9	INF	TNFRSF1A, , CP, SOD1, LTA, PDE5A
49	aspartate32	INF	COL2A1, , PMP22, BDNF, HLA-DQB1, GJB2
50	methotrexate32 34 42 9 9	INF	SERPINE1, MTHFR, MTR, GSTM1, APOH, F2

Cellular components related to sensorineural hearing loss according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basolateral plasma membrane	GO:016323	INF	, EGFR, OTOF, ATP7B, ATP7A, ATP6V1B1
2	stereocilium	GO:032420	INF	, STRC, DFNB31, , ,
3	apical plasma membrane	GO:016324	INF	SLC26A4, , ATP6V0A4, ATP6V1B1, ,
4	stereocilia ankle link complex	GO:002142	9.8	USH2A, GPR98, DFNB31
5	cytosol	GO:005829	INF	, OTOF, NOS1, , PDE5A,
6	filamentous actin	GO:031941	INF	, , , MYO1A, MYO6
7	extracellular space	GO:005615	INF	TNF, TNFRSF1A, COL2A1, NGF, LTA, EGFR
8	photoreceptor inner segment	GO:001917	INF	DFNB31, , MYO7A
9	plasma membrane	GO:005886	INF	HLA-DQB1, GJB6, GJB2, HSPA8, F2, F3

Biological processes related to sensorineural hearing loss according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	inner ear morphogenesis	GO:042472	INF	, SOX2, COL2A1, DLX5, , TMIE
2	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	, TNF, TNFRSF1A, DLX5, NOS1, TWIST1
3	axon guidance	GO:007411	INF	MYH9, , EGFR, COL2A1, , COL4A5
4	sensory perception of light stimulus	GO:050953	INF	DFNB31, GPR98, , USH2A, , MYO7A
5	auditory receptor cell stereocilium organization	GO:060088	INF	SOD1, STRC, , MYO7A
6	anti-apoptosis	GO:006916	INF	, SOD1, NGF, TNF, F3, APOE
7	equilibrioception	GO:050957	INF	, , MYO7A,
8	visual perception	GO:007601	INF	WFS1, , OPA1, COL2A1, EYA4,
9	sensory perception of sound	GO:007605	INF	WFS1, , OTOF, , , TECTA
10	photoreceptor cell maintenance	GO:045494	INF	GPR98, , USH2A, ,
11	outer ear morphogenesis	GO:042473	INF	, HOXA1, TWIST1

Molecular functions related to sensorineural hearing loss according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ADP binding	GO:043531	INF	MYO6, , HSPA8, , MYH9
2	extracellular matrix structural constituent conferring tensile strength	GO:030020	INF	COL2A1, ,
3	copper ion binding	GO:005507	9.5	CP, SOD1, F5, IL1A, ATP7B, ATP7A
4	protease binding	GO:002020	9.1	TNFRSF1A, TNF, F3, SERPINE1, SERPINB6, SERPINC1
5	protein binding	GO:005515	INF	, , TNFRSF1A, TNF, HOXA1, HSPA8
6	actin binding	GO:003779	INF	, , GSN, , MYO1A,