MCID: SNS003
MIFTS: 35

Sensory Peripheral Neuropathy malady

Neuronal diseases category

Summaries for Sensory Peripheral Neuropathy

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A peripheral neuropathy that involves damage to nerves of the peripheral nervous system.

MalaCards: Sensory Peripheral Neuropathy, also known as sensory neuropathy, is related to axonal neuropathy and cerebellar ataxia. An important gene associated with Sensory Peripheral Neuropathy is PLEKHG4 (pleckstrin homology domain containing, family G (with RhoGef domain) member 4), and among its related pathways are Cell cycle Role of APC in cell cycle regulation and Chaperonin-mediated protein folding. Affiliated tissues include skin, testes and monocytes, and related mouse phenotype mortality/aging.

Aliases & Classifications for Sensory Peripheral Neuropathy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

sensory peripheral neuropathy 8 10
sensory neuropathy 8 44 60
peripheral sensory neuropathy 8


External Ids:

Disease Ontology8 DOID:2491
NCIt39 C3501

Related Diseases for Sensory Peripheral Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sensory Peripheral Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1axonal neuropathy30.3PLEKHG4
2cerebellar ataxia30.1PLEKHG4
3hereditary sensory neuropathy11.1
4neuropathy10.6
5peripheral neuropathy10.6
6charcot-marie-tooth disease10.6
7dnmt1-related dementia, deafness, and sensory neuropathy10.6
8anhidrosis10.6
9neuropathy hereditary sensory and autonomic type 110.6
10tooth disease10.5
11hereditary motor and sensory neuropathy with agenesis of the corpus callosum10.5
12paraplegia10.5
13charcot-marie-tooth hereditary neuropathy10.4
14hereditary spastic paraplegia10.4
15autonomic neuropathy10.4
16diabetic neuropathy10.4
17hereditary motor and sensory neuropathy vi10.4
18dementia10.4
19optic atrophy10.4
20charcot-marie-tooth disease with pyramidal features, autosomal dominant10.4
21hereditary sensory neuropathy type ia10.3
22charcot-marie-tooth disease type 2c10.3
23neuropathy, hereditary motor and sensory, okinawa type10.3
24hereditary sensory neuropathy type id10.3
25charcot-marie-tooth disease type 110.3
26neuronitis10.3
27ophthalmoplegia10.3
28spinocerebellar ataxia10.3
29neuropathy, hereditary motor and sensory, russe type10.3
30motor sensory neuropathy type 1 aplasia cutis congenita10.3
31motor peripheral neuropathy10.3
32charcot-marie-tooth disease type 310.2
33infantile onset spinocerebellar ataxia10.2
34keratitis10.2
35hereditary sensory and autonomic neuropathy type ii10.2
36neuropathy, hereditary motor and sensory, lom type10.2
37hereditary neuropathies10.2
38charcot-marie-tooth disease, dominant intermediate b10.2
39refsum disease10.1
40juvenile glaucoma10.1
41homocystinuria10.1
42chronic polyneuropathy10.1
43demyelinating polyneuropathy10.1
44glaucoma10.1
45gonadal dysgenesis10.1
46leprosy10.1
47multiple sclerosis10.1
48polyneuropathy10.1
49hereditary neuropathy with liability to pressure palsies10.1
50charcot-marie-tooth neuropathy type 110.1

Graphical network of the top 20 diseases related to Sensory Peripheral Neuropathy:



Diseases related to sensory peripheral neuropathy

Clinical Features for Sensory Peripheral Neuropathy

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Drugs & Therapeutics for Sensory Peripheral Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Sensory Peripheral Neuropathy

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Genetic Tests for Sensory Peripheral Neuropathy

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Anatomical Context for Sensory Peripheral Neuropathy

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32MalaCards
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MalaCards organs/tissues related to Sensory Peripheral Neuropathy:

32
Skin, Testes, Monocytes

Animal Models for Sensory Peripheral Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sensory Peripheral Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.4ELAVL4, ELAVL3, NUMB, FLVCR1, CRIPT, TNRC6A

Publications for Sensory Peripheral Neuropathy

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50PubMed
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Articles related to Sensory Peripheral Neuropathy:

(show all 34)
idTitleAuthorsYear
1
Sensory improvement of leprosy peripheral neuropathy in patients treated with perineural injection of platelet-rich plasma. (24168291)
2014
2
Pain, Sleep Disturbances, and Functional Limitations in People Living with HIV/AIDS-Associated Distal Sensory Peripheral Neuropathy. (23887924)
2013
3
Sensory loss and walking speed related factors for gait alterations in patients with peripheral neuropathy. (24342450)
2013
4
Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy. (23726937)
2013
5
Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy. (23204130)
2013
6
A commentary on: Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy. (23298520)
2013
7
Acu/Moxa for distal sensory peripheral neuropathy in HIV: a randomized control pilot study. (23582399)
2013
8
Relation of sensory peripheral neuropathy in SjAPgren syndrome to anti-Ro/SSA. (22955477)
2012
9
A longitudinal study of sensory biomarkers of progression in patients with diabetic peripheral neuropathy using skin biopsies. (22705139)
2012
10
Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy. (22465570)
2012
11
Electrophysiological contribution of both sensory branches of the superficial peroneal nerve in the diagnosis of peripheral neuropathy. (23019766)
2012
12
Excitability of AI^ sensory neurons is altered in an animal model of peripheral neuropathy. (22289651)
2012
13
Changes in functional properties of A-type but not C-type sensory neurons in vivo in a rat model of peripheral neuropathy. (22792004)
2012
14
A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101. (22843789)
2012
15
Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat. (22037390)
2011
16
Trigeminal pain and quantitative sensory testing in painful peripheral diabetic neuropathy. (20435295)
2010
17
Lack of motor progression in isolated sensory peripheral neuropathy. (20724263)
2010
18
Protection from clinical peripheral sensory neuropathy in AlstrAPm syndrome in contrast to early-onset type 2 diabetes. (19092165)
2009
19
Peripheral arthropathy in hereditary sensory and autonomic neuropathy types III and IV. (19098654)
2009
20
Peripheral sensory neuropathy associates with micro- or macroangiopathy: results from a population-based study of type 2 diabetic patients in Sweden. (19033412)
2009
21
Gabapentin treatment for notalgia paresthetica, a common isolated peripheral sensory neuropathy. (17958872)
2007
22
Reversible motor and sensory peripheral neuropathy in a patient following acute carbon monoxide intoxication. (15773259)
2005
23
Paraneoplastic encephalomyelitis/sensory motor peripheral neuropathy - an autopsy case study. (16012914)
2005
24
Ultrastructural immunocytochemical abnormalities of peripheral myelin proteins in hereditary sensory-motor neuropathies: 12 cases. (10586244)
1999
25
Lower-extremity amputation in diabetes. The independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers. (10388962)
1999
26
Screening for distal sensory peripheral neuropathy in HIV-infected persons in research and clinical settings. (9855522)
1998
27
Retinal changes in familial peripheral sensory and motor neuropathy associated with anterior cervical hypertrichosis. (9310921)
1997
28
A case of hereditary motor and sensory neuropathy type I with a new type of peripheral myelin protein (PMP)-22 mutation. (8777804)
1995
29
Chronic hexosaminidase A deficiency associated with pure sensory peripheral neuropathy]. (1302293)
1992
30
Familial congenital anterior cervical hypertrichosis associated with peripheral sensory and motor neuropathy--a new syndrome? (1666396)
1991
31
Sensory peripheral neuropathy of vitamin B12 deficiency: a primary demyelinating disease? (2835439)
1988
32
Subepidermal vesicular dermatosis and sensory peripheral neuropathy caused by pyridoxine abuse. (3011864)
1986
33
Sensory and motor peripheral neuropathy in olivopontocerebellar atrophy. (3014798)
1986
34
Peripheral motor and sensory neuropathy of early childhood, simulating Werdnig-Hoffmann disease. (183171)
1976

Genetic Variations for Sensory Peripheral Neuropathy

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Expression for genes affiliated with Sensory Peripheral Neuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sensory Peripheral Neuropathy

Search GEO for disease gene expression data for Sensory Peripheral Neuropathy.

Pathways for genes affiliated with Sensory Peripheral Neuropathy

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12EMD Millipore, 53Reactome
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Compounds for genes affiliated with Sensory Peripheral Neuropathy

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GO Terms for genes affiliated with Sensory Peripheral Neuropathy

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16Gene Ontology
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Cellular components related to Sensory Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zona pellucida receptor complexGO:0021999.3CCT5, CCT4
2chaperonin-containing T-complexGO:0058329.0CCT5, CCT4

Biological processes related to Sensory Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1de novo posttranslational protein foldingGO:0510849.3CCT5, CCT4
2binding of sperm to zona pellucidaGO:0073399.0CCT5, CCT4

Molecular functions related to Sensory Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Rho guanyl-nucleotide exchange factor activityGO:0050899.7PLEKHG4, FGD4
2AU-rich element bindingGO:0170919.3ELAVL4, ELAVL3
3nucleotide bindingGO:0001668.5ELAVL4, ELAVL3, TNRC6A

Products for genes affiliated with Sensory Peripheral Neuropathy

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  • Antibodies
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Sources for Sensory Peripheral Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet