MCID: SPR012
MIFTS: 30

Separation Anxiety Disorder malady

Summaries for Separation Anxiety Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards: Separation Anxiety Disorder is related to personality disorder and mood disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (dopamine receptor D4), and among its related pathways is Circadian entrainment. The compounds raclopride and piperazine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia:63 Separation anxiety disorder (SAD) is a psychological condition in which an individual experiences... more...

Aliases & Classifications for Separation Anxiety Disorder

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8Disease Ontology, 60UMLS
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Aliases & Descriptions:

separation anxiety disorder 8 60


External Ids:

Disease Ontology8 DOID:10685

Related Diseases for Separation Anxiety Disorder

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to separation anxiety disorder

Clinical Features for Separation Anxiety Disorder

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Drugs & Therapeutics for Separation Anxiety Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Separation Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Separation Anxiety Disorder

Search NIH Clinical Center for Separation Anxiety Disorder

Search CenterWatch for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

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Anatomical Context for Separation Anxiety Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Separation Anxiety Disorder:

32
Eye

Animal Models for Separation Anxiety Disorder or affiliated genes

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Publications for Separation Anxiety Disorder

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50PubMed
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Articles related to Separation Anxiety Disorder:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Patterns of family identification and self-congruence in childhood separation anxiety disorder. (23751201)
2014
2
Adult separation anxiety disorder in DSM-5. (23673209)
2013
3
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
4
Separation anxiety disorder: lumping or splitting? (23493754)
2013
5
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. (23607501)
2013
6
Looking for balance between promoting adult separation anxiety disorder and overlooking it. (23901151)
2013
7
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. (23963543)
2013
8
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. (23247205)
2013
9
DSM-5 allows separation anxiety disorder to grow up. (23293308)
2013
10
Predictors of response among patients with panic disorder treated with medications in a naturalistic follow-up: the role of adult separation anxiety. (22134042)
2012
11
Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis. (22461084)
2012
12
The relationship between adult separation anxiety disorder and complicated grief in a cohort of 454 outpatients with mood and anxiety disorders. (22832169)
2012
13
Does the vigilance-avoidance gazing behavior of children with separation anxiety disorder change after cognitive-behavioral therapy? (22466517)
2012
14
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. (21309628)
2011
15
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial. (21494062)
2011
16
Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. (20731709)
2010
17
The prevalence and correlates of adult separation anxiety disorder in an anxiety clinic. (20219138)
2010
18
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. (20675099)
2010
19
Adult separation anxiety disorder among war-affected Bosnian refugees: comorbidity with PTSD and associations with dimensions of trauma. (20135680)
2010
20
Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. (19813086)
2010
21
Forced choice reaction time paradigm in children with separation anxiety disorder, social phobia, and nonanxious controls. (19733835)
2009
22
Development and Preliminary Evaluation of a 1-Week Summer Treatment Program for Separation Anxiety Disorder. (21935300)
2009
23
Adult attachment styles in panic disorder with and without comorbid adult separation anxiety disorder. (19153925)
2009
24
Separation anxiety disorder and school refusal in childhood: potential risk factors for developing distinct psychiatric disorders? (18311428)
2008
25
The unique impact of parent training for separation anxiety disorder in children. (18502252)
2008
26
Separation anxiety disorder in childhood as a risk factor for future mental illness. (18356763)
2008
27
Separation anxiety disorder in a 13-year-old boy managed by the Neuro Emotional Technique as a biopsychosocial intervention. (19646371)
2008
28
Separation anxiety disorder and school refusal in children and adolescents. (16452275)
2006
29
Prevalence and correlates of estimated DSM-IV child and adult separation anxiety disorder in the National Comorbidity Survey Replication. (16741209)
2006
30
Separation anxiety disorder. (15768687)
2005
31
Asperger's disorder with co-morbid separation anxiety disorder: a case report. (15796129)
2005
32
Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms. (15830231)
2005
33
Childhood separation anxiety and separation events in women with agoraphobia with or without panic disorder. (16494264)
2005
34
Risk for separation anxiety disorder among girls: paternal absence, socioeconomic disadvantage, and genetic vulnerability. (15122944)
2004
35
Course and short-term outcomes of separation anxiety disorder in a community sample of twins. (15322414)
2004
36
Is childhood separation anxiety disorder a predictor of adult panic disorder and agoraphobia? A seven-year longitudinal study. (14627883)
2003
37
Associations between juvenile and adult forms of separation anxiety disorder: a study of adult volunteers with histories of school refusal. (12080215)
2002
38
Cognitive-behavioral therapy with a six-year-old boy with separation anxiety disorder: a case study. (11378998)
2001
39
Separation anxiety disorder in children and adolescents: epidemiology, diagnosis and management. (11460893)
2001
40
Separation anxiety disorder: planning treatment. (10878189)
2000
41
Dysfunctional cognitions in children with social phobia, separation anxiety disorder, and generalized anxiety disorder. (10834771)
2000
42
Is there an adult form of separation anxiety disorder? A brief clinical report. (9140640)
1997
43
School phobia with separation anxiety disorder: a comparative 20- to 29-year follow-up study of 35 school refusers. (8980867)
1997
44
Traits of separation anxiety in boys with gender identity disorder. (8682760)
1996
45
Understanding separation anxiety disorder. (7795948)
1995
46
Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder. (7653694)
1995
47
Childhood separation anxiety disorder in patients with adult anxiety disorders. (8185008)
1994
48
Imipramine treatment of children with separation anxiety disorder. (1347039)
1992
49
Boyhood separation anxiety disorder: thought disorder and object relations psychopathology as manifested in Rorschach imagery. (2724040)
1989
50
Expression of separation anxiety disorder: the roles of age and gender. (3436175)
1987

Genetic Variations for Separation Anxiety Disorder

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Expression for genes affiliated with Separation Anxiety Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for genes affiliated with Separation Anxiety Disorder

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29KEGG
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Pathways related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1SLC6A3, DRD4

Compounds for genes affiliated with Separation Anxiety Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1raclopride44 2810.5SLC6A3, DRD4
2piperazine44 1110.5SLC6A3, DRD4
3methylphenidate44 49 1111.5SLC6A3, DRD4
4sulpiride44 28 1111.5SLC6A3, DRD4
5piperidine449.5DRD4, SLC6A3
6maoa449.5SLC6A3, DRD4
7pramipexole44 49 28 1112.5SLC6A3, DRD4
8phencyclidine44 28 1111.5DRD4, SLC6A3
9quinpirole44 2810.5DRD4, SLC6A3
10heroin44 49 1111.5SLC6A3, DRD4
11paroxetine44 49 28 1112.5SLC6A3, DRD4
12apomorphine44 28 1111.5DRD4, SLC6A3
13quetiapine44 49 28 11 2413.5SLC6A3, DRD4
14risperidone28 44 49 59 11 2414.4SLC6A3, DRD4
15bromocriptine28 44 1111.4SLC6A3, DRD4
16methamphetamine44 49 1111.4DRD4, SLC6A3
176-hydroxydopamine449.4SLC6A3, DRD4
18amphetamine44 1110.4SLC6A3, DRD4
19olanzapine49 44 28 11 2413.4SLC6A3, DRD4
20levodopa44 1110.4DRD4, SLC6A3
21clozapine44 28 49 1112.4SLC6A3, DRD4
22haloperidol44 28 2 49 1113.3SLC6A3, DRD4
23cocaine44 1110.3DRD4, SLC6A3
245-hydroxytryptamine449.3SLC6A3, DRD4
25nicotine44 49 28 1112.2SLC6A3, DRD4
26valine449.2SLC6A3, DRD4
27gaba449.1DRD4, SLC6A3
28sodium44 2410.1SLC6A3, DRD4
29norepinephrine44 11 2411.0SLC6A3, DRD4
30dopamine44 28 11 2411.8SLC6A3, DRD4

GO Terms for genes affiliated with Separation Anxiety Disorder

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16Gene Ontology
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Cellular components related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.1SLC6A3, DRD4

Biological processes related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:0420539.1SLC6A3, DRD4

Molecular functions related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD4
2dopamine bindingGO:0352408.8SLC6A3, DRD4

Products for genes affiliated with Separation Anxiety Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Separation Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet