MCID: SPR012
MIFTS: 28

Separation Anxiety Disorder malady

Mental diseases category

Summaries for Separation Anxiety Disorder

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Disease Ontology:9 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary: Separation Anxiety Disorder, also known as separation anxiety disorder of childhood, is related to personality disorder and oppositional defiant disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (dopamine receptor D4), and among its related pathways is Circadian entrainment. The compounds raclopride and piperazine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia:63 Separation anxiety disorder (SAD) is a psychological condition in which an individual experiences... more...

Aliases & Classifications for Separation Anxiety Disorder

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Separation Anxiety Disorder, Aliases & Descriptions:

Name: Separation Anxiety Disorder 9 60
 
Separation Anxiety Disorder of Childhood 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:10685
ICD1025 F93.0

Related Diseases for Separation Anxiety Disorder

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Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to separation anxiety disorder

Symptoms for Separation Anxiety Disorder

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Drugs & Therapeutics for Separation Anxiety Disorder

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Drug clinical trials:

Search ClinicalTrials for Separation Anxiety Disorder

Search NIH Clinical Center for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

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Anatomical Context for Separation Anxiety Disorder

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MalaCards organs/tissues related to Separation Anxiety Disorder:

31
Eye

Animal Models for Separation Anxiety Disorder or affiliated genes

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Publications for Separation Anxiety Disorder

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Articles related to Separation Anxiety Disorder:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Separation anxiety disorder from the perspective of DSM-5: clinical investigation among subjects with panic disorder and associations with mood disorders spectrum. (25704393)
2015
2
Adult separation anxiety disorder: accepted but little understood. (25572307)
2015
3
Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates. (24908152)
2014
4
The right amygdalar tumor presenting with symptoms of separation anxiety disorder (SAD): a case report. (24593853)
2014
5
Separation anxiety disorder across the lifespan: DSM-5 lifts age restriction on diagnosis. (25453710)
2014
6
Patterns of family identification and self-congruence in childhood separation anxiety disorder. (23751201)
2014
7
The effective comparison between emotion-focused cognitive behavioral group therapy and cognitive behavioral group therapy in children with separation anxiety disorder. (24949029)
2014
8
Early-life risk factors for panic and separation anxiety disorder: Insights and outstanding questions arising from human and animal studies of CO2 sensitivity. (24793177)
2014
9
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
10
Adult separation anxiety disorder in DSM-5. (23673209)
2013
11
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
12
Separation anxiety disorder: lumping or splitting? (23493754)
2013
13
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. (23607501)
2013
14
Looking for balance between promoting adult separation anxiety disorder and overlooking it. (23901151)
2013
15
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. (23963543)
2013
16
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. (23247205)
2013
17
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. (24064331)
2013
18
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. (22922077)
2013
19
DSM-5 allows separation anxiety disorder to grow up. (23293308)
2013
20
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. (22542862)
2012
21
Separation anxiety disorder increases among neonatal intensive care unit graduates. (21819341)
2012
22
Temperament and character dimensions of patients with adult separation anxiety disorder. (22440427)
2012
23
Separation anxiety disorder in OCD. (21308883)
2011
24
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. (21309628)
2011
25
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial. (21494062)
2011
26
Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. (20731709)
2010
27
The prevalence and correlates of adult separation anxiety disorder in an anxiety clinic. (20219138)
2010
28
Adult separation anxiety disorder: a disorder comes of age. (20552302)
2010
29
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. (20675099)
2010
30
Adult separation anxiety disorder among war-affected Bosnian refugees: comorbidity with PTSD and associations with dimensions of trauma. (20135680)
2010
31
SEPARATION ANXIETY DISORDER IN YOUTH: PHENOMENOLOGY, ASSESSMENT, AND TREATMENT. (19966943)
2008
32
Separation anxiety disorder and school refusal in childhood: potential risk factors for developing distinct psychiatric disorders? (18311428)
2008
33
The unique impact of parent training for separation anxiety disorder in children. (18502252)
2008
34
Separation anxiety disorder in childhood as a risk factor for future mental illness. (18356763)
2008
35
Separation anxiety disorder in a 13-year-old boy managed by the Neuro Emotional Technique as a biopsychosocial intervention. (19646371)
2008
36
Separation anxiety disorder and school refusal in children and adolescents. (16452275)
2006
37
Separation anxiety disorder. (15768687)
2005
38
Asperger's disorder with co-morbid separation anxiety disorder: a case report. (15796129)
2005
39
Separation anxiety disorder, panic disorder, and school refusal. (16171702)
2005
40
Informant disagreement for separation anxiety disorder. (15187805)
2004
41
Risk for separation anxiety disorder among girls: paternal absence, socioeconomic disadvantage, and genetic vulnerability. (15122944)
2004
42
Course and short-term outcomes of separation anxiety disorder in a community sample of twins. (15322414)
2004
43
Associations between juvenile and adult forms of separation anxiety disorder: a study of adult volunteers with histories of school refusal. (12080215)
2002
44
Separation anxiety disorder: planning treatment. (10878189)
2000
45
Is there an adult form of separation anxiety disorder? A brief clinical report. (9140640)
1997
46
Understanding separation anxiety disorder. (7795948)
1995
47
Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder. (7653694)
1995
48
Childhood separation anxiety disorder in patients with adult anxiety disorders. (8185008)
1994
49
Boyhood separation anxiety disorder: thought disorder and object relations psychopathology as manifested in Rorschach imagery. (2724040)
1989
50
Expression of separation anxiety disorder: the roles of age and gender. (3436175)
1987

Variations for Separation Anxiety Disorder

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Expression for genes affiliated with Separation Anxiety Disorder

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Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for genes affiliated with Separation Anxiety Disorder

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Pathways related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1SLC6A3, DRD4

Compounds for genes affiliated with Separation Anxiety Disorder

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Compounds related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 31)
idCompoundScoreTop Affiliating Genes
1raclopride43 2810.5SLC6A3, DRD4
2piperazine43 1210.5SLC6A3, DRD4
3sulpiride43 28 1211.5SLC6A3, DRD4
4methylphenidate43 49 1211.5SLC6A3, DRD4
5piperidine439.5DRD4, SLC6A3
6maoa439.5SLC6A3, DRD4
7pramipexole43 28 49 1212.5SLC6A3, DRD4
8phencyclidine43 28 1211.5DRD4, SLC6A3
9quinpirole43 2810.5DRD4, SLC6A3
10heroin43 49 1211.5SLC6A3, DRD4
11paroxetine43 49 28 1212.5DRD4, SLC6A3
12apomorphine28 43 1211.5DRD4, SLC6A3
13quetiapine43 49 28 24 1213.5SLC6A3, DRD4
14bromocriptine43 28 1211.5SLC6A3, DRD4
15methamphetamine43 49 1211.4SLC6A3, DRD4
16risperidone43 49 28 59 24 1214.4DRD4, SLC6A3
176-hydroxydopamine439.4SLC6A3, DRD4
18amphetamine43 49 1211.4SLC6A3, DRD4
19olanzapine43 49 28 24 1213.4SLC6A3, DRD4
20levodopa43 1210.4DRD4, SLC6A3
21clozapine43 28 49 1212.4SLC6A3, DRD4
22haloperidol43 49 28 2 1213.4SLC6A3, DRD4
23cocaine43 1210.3SLC6A3, DRD4
245-hydroxytryptamine439.3DRD4, SLC6A3
25nicotine43 28 49 1212.3SLC6A3, DRD4
26valine439.2SLC6A3, DRD4
27gaba439.2SLC6A3, DRD4
28norepinephrine43 24 1211.1DRD4, SLC6A3
29glutamate439.1SLC6A3, DRD4
30dopamine43 28 24 1212.0SLC6A3, DRD4
31sodium43 249.8SLC6A3, DRD4

GO Terms for genes affiliated with Separation Anxiety Disorder

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Cellular components related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058879.1SLC6A3, DRD4
2neuronal cell bodyGO:00430258.8SLC6A3, DRD4

Biological processes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:00420539.1SLC6A3, DRD4

Molecular functions related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00081449.1SLC6A3, DRD4
2dopamine bindingGO:00352408.8SLC6A3, DRD4

Products for genes affiliated with Separation Anxiety Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Separation Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet