MCID: SPR012
MIFTS: 27

Separation Anxiety Disorder malady

Summaries for Separation Anxiety Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards: Separation Anxiety Disorder is related to anxiety disorder and panic disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (dopamine receptor D4), and among its related pathways is Circadian entrainment. The compounds raclopride and piperazine have been mentioned in the context of this disorder.

Wikipedia:64 Separation anxiety disorder (SAD) is a psychological condition in which an individual experiences... more...

Aliases & Classifications for Separation Anxiety Disorder

Sources:
8Disease Ontology, 61UMLS
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Aliases & Descriptions:

separation anxiety disorder 8 61


External Ids:

Disease Ontology8 DOID:10685

Related Diseases for Separation Anxiety Disorder

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to separation anxiety disorder

Clinical Features for Separation Anxiety Disorder

Drugs & Therapeutics for Separation Anxiety Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Separation Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Separation Anxiety Disorder

Search NIH Clinical Center for Separation Anxiety Disorder

Search CenterWatch for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

Anatomical Context for Separation Anxiety Disorder

Animal Models for Separation Anxiety Disorder or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Separation Anxiety Disorder

Sources:
51PubMed
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Articles related to Separation Anxiety Disorder:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Patterns of family identification and self-congruence in childhood separation anxiety disorder. (23751201)
2014
2
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
3
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
4
The separation anxiety hypothesis of panic disorder revisited: a meta-analysis. (23680783)
2013
5
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. (23963543)
2013
6
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. (23247205)
2013
7
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. (24064331)
2013
8
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. (22922077)
2013
9
Separation anxiety disorder in adults: is the neglect real? (23382511)
2013
10
A randomized controlled trial of the child anxiety multi-day program (cAMP) for separation anxiety disorder. (23053618)
2013
11
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. (22542862)
2012
12
Separation anxiety disorder increases among neonatal intensive care unit graduates. (21819341)
2012
13
Temperament and character dimensions of patients with adult separation anxiety disorder. (22440427)
2012
14
Lifetime mood symptoms and adult separation anxiety in patients with complicated grief and/or post-traumatic stress disorder: a preliminary report. (22436352)
2012
15
Separation anxiety disorder in children: disorder-specific responses to experimental separation from the mother. (21923807)
2012
16
Separation anxiety disorder in OCD. (21308883)
2011
17
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. (21309628)
2011
18
Early predictors of separation anxiety disorder: early stranger anxiety, parental pathology and prenatal factors. (21847002)
2011
19
Children suffering from separation anxiety disorder (SAD) show increased HPA axis activity compared to healthy controls. (20870248)
2011
20
The prevalence and correlates of adult separation anxiety disorder in an anxiety clinic. (20219138)
2010
21
Adult separation anxiety disorder: a disorder comes of age. (20552302)
2010
22
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. (20675099)
2010
23
Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. (19813086)
2010
24
Forced choice reaction time paradigm in children with separation anxiety disorder, social phobia, and nonanxious controls. (19733835)
2009
25
Adult attachment styles in panic disorder with and without comorbid adult separation anxiety disorder. (19153925)
2009
26
SEPARATION ANXIETY DISORDER IN YOUTH: PHENOMENOLOGY, ASSESSMENT, AND TREATMENT. (19966943)
2008
27
Separation anxiety disorder. (15768687)
2005
28
Asperger's disorder with co-morbid separation anxiety disorder: a case report. (15796129)
2005
29
Separation anxiety disorder, panic disorder, and school refusal. (16171702)
2005
30
Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms. (15830231)
2005
31
Informant disagreement for separation anxiety disorder. (15187805)
2004
32
Course and short-term outcomes of separation anxiety disorder in a community sample of twins. (15322414)
2004
33
Separation anxiety disorder in young children: a longitudinal and family analysis. (14710468)
2003
34
Is childhood separation anxiety disorder a predictor of adult panic disorder and agoraphobia? A seven-year longitudinal study. (14627883)
2003
35
Associations between juvenile and adult forms of separation anxiety disorder: a study of adult volunteers with histories of school refusal. (12080215)
2002
36
Rapid resolution of social anxiety disorder, selective mutism, and separation anxiety with paroxetine in an 8-year-old girl. (11944508)
2002
37
Parenting received in childhood and early separation anxiety in male conscripts with adjustment disorder. (11799809)
2002
38
Comorbidity of dependent personality disorder and separation anxiety disorder in addictive disorders and in healthy subjects. (12239442)
2002
39
Relationship between separation anxiety disorder, parental panic disorder, and atopic disorders in children: a controlled high-risk study. (12162630)
2002
40
Genetic and environmental influences on separation anxiety disorder symptoms and their moderation by age and sex. (11777169)
2001
41
Dysfunctional cognitions in children with social phobia, separation anxiety disorder, and generalized anxiety disorder. (10834771)
2000
42
Parental representations associated with adult separation anxiety and panic disorder--agoraphobia. (10442800)
1999
43
Traits of separation anxiety in boys with gender identity disorder. (8682760)
1996
44
Understanding separation anxiety disorder. (7795948)
1995
45
Is early separation anxiety a specific precursor of panic disorder-agoraphobia? A community study. (7675927)
1995
46
Childhood separation anxiety disorder in patients with adult anxiety disorders. (8185008)
1994
47
Imipramine treatment of children with separation anxiety disorder. (1347039)
1992
48
The prevalence of overanxious disorder and separation anxiety disorder: results from the Ontario Child Health Study. (2228929)
1990
49
Boyhood separation anxiety disorder: thought disorder and object relations psychopathology as manifested in Rorschach imagery. (2724040)
1989
50
Behavior therapy for separation anxiety disorder. (3069093)
1988

Genetic Variations for Separation Anxiety Disorder

Expression for genes affiliated with Separation Anxiety Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for genes affiliated with Separation Anxiety Disorder

Sources:
30KEGG
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Pathways related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1SLC6A3, DRD4

Compounds for genes affiliated with Separation Anxiety Disorder

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1raclopride45 2910.5SLC6A3, DRD4
2piperazine45 1110.5DRD4, SLC6A3
3sulpiride45 29 1111.5DRD4, SLC6A3
4methylphenidate45 50 1111.5DRD4, SLC6A3
5piperidine459.5SLC6A3, DRD4
6maoa459.5DRD4, SLC6A3
7pramipexole45 50 29 1112.5SLC6A3, DRD4
8phencyclidine45 29 1111.5DRD4, SLC6A3
9quinpirole45 2910.5SLC6A3, DRD4
10heroin45 50 1111.5DRD4, SLC6A3
11paroxetine45 50 29 1112.5DRD4, SLC6A3
12apomorphine45 29 1111.5SLC6A3, DRD4
13quetiapine45 50 29 11 2413.5SLC6A3, DRD4
14risperidone29 45 50 60 11 2414.4SLC6A3, DRD4
15bromocriptine29 45 1111.4DRD4, SLC6A3
16methamphetamine45 50 1111.4SLC6A3, DRD4
176-hydroxydopamine459.4DRD4, SLC6A3
18amphetamine45 1110.4DRD4, SLC6A3
19olanzapine50 45 29 11 2413.4DRD4, SLC6A3
20levodopa45 1110.4SLC6A3, DRD4
21clozapine45 29 50 1112.4DRD4, SLC6A3
22haloperidol45 29 2 50 1113.3DRD4, SLC6A3
23cocaine45 1110.3SLC6A3, DRD4
245-hydroxytryptamine459.3DRD4, SLC6A3
25nicotine45 50 29 1112.2SLC6A3, DRD4
26valine459.2SLC6A3, DRD4
27gaba459.1SLC6A3, DRD4
28sodium45 2410.1DRD4, SLC6A3
29norepinephrine45 11 2411.0DRD4, SLC6A3
30dopamine45 29 11 2411.8DRD4, SLC6A3

GO Terms for genes affiliated with Separation Anxiety Disorder

Sources:
16Gene Ontology
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Cellular components related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.1SLC6A3, DRD4

Biological processes related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:0420539.1SLC6A3, DRD4

Molecular functions related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD4
2dopamine bindingGO:0352408.8SLC6A3, DRD4

Products for genes affiliated with Separation Anxiety Disorder

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  • Proteins
  • Lysates
  • Antibodies

Sources for Separation Anxiety Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet