MCID: SPR012
MIFTS: 33

Separation Anxiety Disorder malady

Categories: Mental diseases

Aliases & Classifications for Separation Anxiety Disorder

Aliases & Descriptions for Separation Anxiety Disorder:

Name: Separation Anxiety Disorder 12 14 69
Separation Anxiety Disorder of Childhood 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10685
ICD10 33 F93.0

Summaries for Separation Anxiety Disorder

Disease Ontology : 12 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary : Separation Anxiety Disorder, also known as separation anxiety disorder of childhood, is related to personality disorder and autism spectrum disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (Dopamine Receptor D4). The drugs Midazolam and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 71 Separation anxiety disorder (SAD), is an anxiety disorder in which an individual experiences excessive... more...

Related Diseases for Separation Anxiety Disorder

Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to Separation Anxiety Disorder

Symptoms & Phenotypes for Separation Anxiety Disorder

MGI Mouse Phenotypes related to Separation Anxiety Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 GTF2I HTR7 LTBP3 MB21D1 OXT PRL
2 nervous system MP:0003631 9.32 DRD4 EPRS GTF2I HTR7 OXT PHGDH

Drugs & Therapeutics for Separation Anxiety Disorder

Drugs for Separation Anxiety Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
2
Citalopram Approved Phase 4,Phase 1 59729-33-8 2771
3
Sertraline Approved Phase 4,Phase 3 79617-96-2 68617
4
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 1,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
5
Ketamine Approved, Vet_approved Phase 4,Phase 1,Phase 2 6740-88-1 3821
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8
Alfentanil Approved, Illicit Phase 4 71195-58-9 51263
9
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
10
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
11
Vortioxetine Approved Phase 4 508233-74-7 9966051
12 Antidepressive Agents Phase 4,Phase 3,Phase 1
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
15 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1
16
Serotonin Phase 4,Phase 3,Phase 1 50-67-9 5202
17 Serotonin Agents Phase 4,Phase 3,Phase 1
18 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 1
19 Adjuvants, Anesthesia Phase 4,Phase 3,Phase 2,Phase 1
20 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
21 Anesthetics, General Phase 4,Phase 3,Phase 2,Phase 1
22 Anesthetics, Intravenous Phase 4,Phase 3,Phase 2,Phase 1
23 Anti-Anxiety Agents Phase 4,Phase 3,Phase 2,Phase 1
24 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
25 GABA Agents Phase 4,Phase 3,Phase 2,Phase 1
26 GABA Modulators Phase 4,Phase 3,Phase 2,Phase 1
27 Hypnotics and Sedatives Phase 4,Phase 3,Phase 2,Phase 1
28 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
29 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Antiparkinson Agents Phase 4,Phase 1
31 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 1
32 Autonomic Agents Phase 4,Phase 1
33 Cholinergic Agents Phase 4,Phase 1
34 Cholinergic Antagonists Phase 4,Phase 1
35 Muscarinic Antagonists Phase 4,Phase 1
36 Parasympatholytics Phase 4,Phase 1
37 Adrenergic Agents Phase 4,Phase 2,Phase 1
38 Adrenergic Agonists Phase 4,Phase 2,Phase 1
39 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Phase 1
40 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 1
41 Analgesics Phase 4,Phase 1,Phase 2
42 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2
43 Anesthetics, Dissociative Phase 4,Phase 1,Phase 2
44 Excitatory Amino Acid Antagonists Phase 4,Phase 1,Phase 2
45 Excitatory Amino Acids Phase 4,Phase 1,Phase 2
46 Anesthetics, Local Phase 4
47 Anti-Arrhythmia Agents Phase 4
48 Diuretics, Potassium Sparing Phase 4
49 Epinephryl borate Phase 4
50 Racepinephrine Phase 4

Interventional clinical trials:

(show top 50) (show all 75)
id Name Status NCT ID Phase
1 Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents Completed NCT01160588 Phase 4
2 Dexmedetomidine Premedication in Children Completed NCT03174678 Phase 4
3 Intranasal Dexmedetomidine vs Midazolam-ketamine Combination for Premedication of Pediatric Patients Completed NCT02072083 Phase 4
4 The Effect of Parental Presence on Dental Fear Completed NCT02619981 Phase 4
5 Sevoflurane Induced Emergence Agitation Completed NCT02022488 Phase 4
6 Plasma Gabapentin Concentration During and Following Cardiac Bypass Completed NCT01022736 Phase 4
7 A Comparison of Two Doses of Intranasal Dexmedetomidine for Premedication in Children Recruiting NCT02459509 Phase 4
8 Ketamine Infusion for Adolescent Depression and Anxiety Recruiting NCT02579928 Phase 4
9 Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine Recruiting NCT02969876 Phase 4
10 Vilazodone for Separation Anxiety Disorder Active, not recruiting NCT01999920 Phase 4
11 Developing New Clinical Management Strategies Active, not recruiting NCT02082392 Phase 4
12 Sedation in the Intensive Care Unit Unknown status NCT00221520 Phase 3
13 Treatment for Anxiety in Children Completed NCT00000389 Phase 3
14 Computerized Cognitive Behavioral Therapy for Childhood Anxiety in Community Health Centers Completed NCT01416805 Phase 3
15 Child and Adolescent Anxiety Disorders (CAMS) Completed NCT00052078 Phase 3
16 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
17 A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder Completed NCT00922636 Phase 2, Phase 3
18 A Comparison of Midazolam and Zolpidem as Oral Premedication in Children Completed NCT02096900 Phase 3
19 Reduction of Preoperative Anxiety in Children: Electronic Tab vs Midazolam Completed NCT02192710 Phase 3
20 Study to See if Microcoil Insertion Reduces the Rate of Open Thoracotomy for Removal of Lung Nodules Completed NCT01028417 Phase 3
21 Psychotherapy for Anxiety in Children With Autism Spectrum Disorder Recruiting NCT02028247 Phase 3
22 Treatment Study for Rural Latino Youth With Anxiety Unknown status NCT01491880 Phase 1, Phase 2
23 SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP) Completed NCT01470469 Phase 2
24 Modular Cognitive Behavioral Therapy for the Treatment of Child Anxiety Disorders in Elementary School Settings Completed NCT00569829 Phase 2
25 Effects of Parental Behavior on Child Anxiety Regulation Completed NCT00593515 Phase 2
26 Effectiveness Study of CBT for Anxiety in Children Completed NCT00586586 Phase 2
27 Effectiveness of Cognitive Behavioral Therapy (CBT) for Child Anxiety Disorders in Community Clinics in Norway Completed NCT00735995 Phase 2
28 A GameBoy as a Distraction Before Surgery in Children Completed NCT00176670 Phase 2
29 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
30 Premedication With Nebulized Ketamine,Dexmedetomidine Versus Midazolam in Oncologic Preschool Children Recruiting NCT02935959 Phase 1, Phase 2
31 Cipralex® for Anxiety Disorders in Adolescents Unknown status NCT01293838 Phase 1
32 A Research Study of How Teens With and Without an Anxiety Disorder Make Decisions Completed NCT00104195 Phase 1
33 G-CSF to Treat Crohn's Disease Completed NCT00025805 Phase 1
34 Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children Unknown status NCT01687764
35 Comorbidity Between Balance and Childhood Anxiety Unknown status NCT00599742
36 Effectiveness of Music Therapy Unknown status NCT01040611
37 Assessing Different Methods of Anxiety Care in Pediatric Settings Unknown status NCT00769925
38 TAFF-Psychological Treatment of Separation Anxiety Disorder Completed NCT00255112
39 Cartoon Distraction and Parental Presence on Anxiety in Pediatric Anesthesia Completed NCT02027844
40 Internet-delivered Treatment for Children With Anxiety Disorders in a Rural Area; an Open Trial in a Clinical Setting Completed NCT02306356
41 Transdisciplinary Studies of CBT for Anxiety in Youth: Child Anxiety Treatment Study Completed NCT00774150
42 Sleep, Mood, and Behavior Study Completed NCT00787397
43 Treatment of Youth With ADHD and Anxiety Completed NCT00012584
44 Internet-delivered Cognitive Behavior Therapy (CBT) for Children Age 8-12 Years With Anxiety Disorders Completed NCT01533402
45 Ventilatory Physiology in Children at Risk for Anxiety Completed NCT00101777
46 Reward-Related Processes and Brain Function Completed NCT00029588
47 Computer- Assisted Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01565629
48 Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism Completed NCT01563003
49 CO2 Inhalation and Risk for Panic Disorder Completed NCT00930657
50 Youth Mayo Clinic Anxiety Coach Pilot Study Completed NCT02205177

Search NIH Clinical Center for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

Anatomical Context for Separation Anxiety Disorder

MalaCards organs/tissues related to Separation Anxiety Disorder:

39
Eye

Publications for Separation Anxiety Disorder

Articles related to Separation Anxiety Disorder:

(show top 50) (show all 86)
id Title Authors Year
1
Adult separation anxiety disorder in complicated grief: an exploratory study on frequency and correlates. ( 27683967 )
2017
2
The DSM-5 Dimensional Anxiety Scales in a Dutch non-clinical sample: psychometric properties including the adult separation anxiety disorder scale. ( 27378317 )
2016
3
The separation of adult separation anxiety disorder. ( 27503572 )
2016
4
Can separation anxiety disorder escape its attachment to childhood? ( 27265693 )
2016
5
Separation Anxiety Disorder in School-Age Children: What Health Care Providers Should Know. ( 28012800 )
2016
6
Why are we still missing adult separation anxiety disorder in clinical practice? ( 27343899 )
2016
7
Associations of adult separation anxiety disorder with conflict-related trauma, ongoing adversity, and the psychosocial disruptions of mass conflict among West Papuan refugees. ( 26752442 )
2016
8
Adult separation anxiety disorder: accepted but little understood. ( 25572307 )
2015
9
Dependent personality, separation anxiety disorder and other anxiety disorders in OCD. ( 26542617 )
2015
10
Psychopathology among parents of children and adolescents with separation anxiety disorder. ( 25605571 )
2015
11
Pediatric-Onset and Adult-Onset Separation Anxiety Disorder Across Countries in the World Mental Health Survey. ( 26046337 )
2015
12
Separation anxiety disorder from the perspective of DSM-5: clinical investigation among subjects with panic disorder and associations with mood disorders spectrum. ( 25704393 )
2015
13
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. ( 23591000 )
2014
14
The right amygdalar tumor presenting with symptoms of separation anxiety disorder (SAD): a case report. ( 24593853 )
2014
15
Patterns of family identification and self-congruence in childhood separation anxiety disorder. ( 23751201 )
2014
16
Separation anxiety disorder across the lifespan: DSM-5 lifts age restriction on diagnosis. ( 25453710 )
2014
17
The relationships among separation anxiety disorder, adult attachment style and agoraphobia in patients with panic disorder. ( 25218272 )
2014
18
The effective comparison between emotion-focused cognitive behavioral group therapy and cognitive behavioral group therapy in children with separation anxiety disorder. ( 24949029 )
2014
19
Early-life risk factors for panic and separation anxiety disorder: Insights and outstanding questions arising from human and animal studies of CO2 sensitivity. ( 24793177 )
2014
20
Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates. ( 24908152 )
2014
21
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. ( 23607501 )
2013
22
A randomized controlled trial of the child anxiety multi-day program (cAMP) for separation anxiety disorder. ( 23053618 )
2013
23
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. ( 23963543 )
2013
24
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. ( 24064331 )
2013
25
Adult separation anxiety disorder in DSM-5. ( 23673209 )
2013
26
Separation anxiety disorder: lumping or splitting? ( 23493754 )
2013
27
Separation anxiety disorder in adults: is the neglect real? ( 23382511 )
2013
28
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. ( 23247205 )
2013
29
DSM-5 allows separation anxiety disorder to grow up. ( 23293308 )
2013
30
Let's not abandon separation anxiety disorder in adulthood. ( 23901150 )
2013
31
Looking for balance between promoting adult separation anxiety disorder and overlooking it. ( 23901151 )
2013
32
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. ( 22922077 )
2013
33
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. ( 22542862 )
2012
34
Separation anxiety disorder in children: disorder-specific responses to experimental separation from the mother. ( 21923807 )
2012
35
Separation anxiety disorder increases among neonatal intensive care unit graduates. ( 21819341 )
2012
36
The relationship between adult separation anxiety disorder and complicated grief in a cohort of 454 outpatients with mood and anxiety disorders. ( 22832169 )
2012
37
Does the vigilance-avoidance gazing behavior of children with separation anxiety disorder change after cognitive-behavioral therapy? ( 22466517 )
2012
38
Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis. ( 22461084 )
2012
39
Temperament and character dimensions of patients with adult separation anxiety disorder. ( 22440427 )
2012
40
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. ( 21309628 )
2011
41
Separation anxiety disorder in OCD. ( 21308883 )
2011
42
Children suffering from separation anxiety disorder (SAD) show increased HPA axis activity compared to healthy controls. ( 20870248 )
2011
43
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial. ( 21494062 )
2011
44
Early predictors of separation anxiety disorder: early stranger anxiety, parental pathology and prenatal factors. ( 21847002 )
2011
45
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. ( 20675099 )
2010
46
Adult separation anxiety disorder among war-affected Bosnian refugees: comorbidity with PTSD and associations with dimensions of trauma. ( 20135680 )
2010
47
Adult separation anxiety disorder: a disorder comes of age. ( 20552302 )
2010
48
Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. ( 20731709 )
2010
49
The prevalence and correlates of adult separation anxiety disorder in an anxiety clinic. ( 20219138 )
2010
50
Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. ( 19813086 )
2010

Variations for Separation Anxiety Disorder

Expression for Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for Separation Anxiety Disorder

GO Terms for Separation Anxiety Disorder

Cellular components related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC class I protein complex GO:0042612 8.62 HLA-A HLA-B

Biological processes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.43 OXT PRL SLC6A3
2 regulation of dopamine metabolic process GO:0042053 9.16 DRD4 SLC6A3
3 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.96 HLA-A HLA-B
4 protection from natural killer cell mediated cytotoxicity GO:0042270 8.62 HLA-A HLA-B

Molecular functions related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CORT OXT PRL
2 dopamine binding GO:0035240 8.62 DRD4 SLC6A3

Sources for Separation Anxiety Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....