MCID: SPR012
MIFTS: 32

Separation Anxiety Disorder malady

Mental diseases category
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Summaries for Separation Anxiety Disorder

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Disease Ontology:8 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary: Separation Anxiety Disorder is related to personality disorder and oppositional defiant disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (dopamine receptor D4), and among its related pathways is Circadian entrainment. The compounds raclopride and piperazine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia:65 Separation anxiety disorder (SAD) is a psychological condition in which an individual experiences... more...

Aliases & Classifications for Separation Anxiety Disorder

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Separation Anxiety Disorder, Aliases & Descriptions:

Name: Separation Anxiety Disorder 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:10685

Related Diseases for Separation Anxiety Disorder

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Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to separation anxiety disorder

Symptoms for Separation Anxiety Disorder

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Drugs & Therapeutics for Separation Anxiety Disorder

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Drug clinical trials:

Search ClinicalTrials for Separation Anxiety Disorder

Search NIH Clinical Center for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

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Anatomical Context for Separation Anxiety Disorder

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MalaCards organs/tissues related to Separation Anxiety Disorder:

32
Eye

Animal Models for Separation Anxiety Disorder or affiliated genes

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Publications for Separation Anxiety Disorder

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Articles related to Separation Anxiety Disorder:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates. (24908152)
2014
2
The right amygdalar tumor presenting with symptoms of separation anxiety disorder (SAD): a case report. (24593853)
2014
3
Patterns of family identification and self-congruence in childhood separation anxiety disorder. (23751201)
2014
4
The effective comparison between emotion-focused cognitive behavioral group therapy and cognitive behavioral group therapy in children with separation anxiety disorder. (24949029)
2014
5
Early-life risk factors for panic and separation anxiety disorder: Insights and outstanding questions arising from human and animal studies of CO2 sensitivity. (24793177)
2014
6
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
7
Adult separation anxiety disorder in DSM-5. (23673209)
2013
8
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
9
Separation anxiety disorder: lumping or splitting? (23493754)
2013
10
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. (23607501)
2013
11
Looking for balance between promoting adult separation anxiety disorder and overlooking it. (23901151)
2013
12
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. (23963543)
2013
13
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. (23247205)
2013
14
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. (24064331)
2013
15
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. (22922077)
2013
16
DSM-5 allows separation anxiety disorder to grow up. (23293308)
2013
17
Separation anxiety disorder in adults: is the neglect real? (23382511)
2013
18
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. (22542862)
2012
19
Separation anxiety disorder increases among neonatal intensive care unit graduates. (21819341)
2012
20
Temperament and character dimensions of patients with adult separation anxiety disorder. (22440427)
2012
21
Separation anxiety disorder in OCD. (21308883)
2011
22
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. (21309628)
2011
23
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial. (21494062)
2011
24
Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. (20731709)
2010
25
The prevalence and correlates of adult separation anxiety disorder in an anxiety clinic. (20219138)
2010
26
Adult separation anxiety disorder: a disorder comes of age. (20552302)
2010
27
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. (20675099)
2010
28
Adult separation anxiety disorder among war-affected Bosnian refugees: comorbidity with PTSD and associations with dimensions of trauma. (20135680)
2010
29
SEPARATION ANXIETY DISORDER IN YOUTH: PHENOMENOLOGY, ASSESSMENT, AND TREATMENT. (19966943)
2008
30
Separation anxiety disorder and school refusal in childhood: potential risk factors for developing distinct psychiatric disorders? (18311428)
2008
31
The unique impact of parent training for separation anxiety disorder in children. (18502252)
2008
32
Separation anxiety disorder in childhood as a risk factor for future mental illness. (18356763)
2008
33
Separation anxiety disorder in a 13-year-old boy managed by the Neuro Emotional Technique as a biopsychosocial intervention. (19646371)
2008
34
Separation anxiety disorder and school refusal in children and adolescents. (16452275)
2006
35
Separation anxiety disorder. (15768687)
2005
36
Asperger's disorder with co-morbid separation anxiety disorder: a case report. (15796129)
2005
37
Separation anxiety disorder, panic disorder, and school refusal. (16171702)
2005
38
Informant disagreement for separation anxiety disorder. (15187805)
2004
39
Risk for separation anxiety disorder among girls: paternal absence, socioeconomic disadvantage, and genetic vulnerability. (15122944)
2004
40
Course and short-term outcomes of separation anxiety disorder in a community sample of twins. (15322414)
2004
41
Separation anxiety disorder in young children: a longitudinal and family analysis. (14710468)
2003
42
Associations between juvenile and adult forms of separation anxiety disorder: a study of adult volunteers with histories of school refusal. (12080215)
2002
43
Cognitive-behavioral therapy with a six-year-old boy with separation anxiety disorder: a case study. (11378998)
2001
44
Separation anxiety disorder: planning treatment. (10878189)
2000
45
Is there an adult form of separation anxiety disorder? A brief clinical report. (9140640)
1997
46
Understanding separation anxiety disorder. (7795948)
1995
47
Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder. (7653694)
1995
48
Childhood separation anxiety disorder in patients with adult anxiety disorders. (8185008)
1994
49
Boyhood separation anxiety disorder: thought disorder and object relations psychopathology as manifested in Rorschach imagery. (2724040)
1989
50
Expression of separation anxiety disorder: the roles of age and gender. (3436175)
1987

Variations for Separation Anxiety Disorder

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Expression for genes affiliated with Separation Anxiety Disorder

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Expression patterns in normal tissues for genes affiliated with Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for genes affiliated with Separation Anxiety Disorder

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Pathways related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1SLC6A3, DRD4

Compounds for genes affiliated with Separation Anxiety Disorder

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Compounds related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1raclopride44 2810.5SLC6A3, DRD4
2piperazine44 1110.5SLC6A3, DRD4
3sulpiride44 28 1111.5SLC6A3, DRD4
4methylphenidate44 50 1111.5SLC6A3, DRD4
5piperidine449.5DRD4, SLC6A3
6maoa449.5SLC6A3, DRD4
7pramipexole44 28 50 1112.5SLC6A3, DRD4
8phencyclidine44 28 1111.5DRD4, SLC6A3
9quinpirole44 2810.5DRD4, SLC6A3
10heroin44 50 1111.5SLC6A3, DRD4
11paroxetine44 50 28 1112.5DRD4, SLC6A3
12apomorphine28 44 1111.5DRD4, SLC6A3
13quetiapine44 50 28 24 1113.5SLC6A3, DRD4
14bromocriptine44 28 1111.5SLC6A3, DRD4
15methamphetamine44 50 1111.4SLC6A3, DRD4
16risperidone44 50 28 61 24 1114.4DRD4, SLC6A3
176-hydroxydopamine449.4SLC6A3, DRD4
18amphetamine44 50 1111.4SLC6A3, DRD4
19olanzapine44 50 28 24 1113.4SLC6A3, DRD4
20levodopa44 1110.4DRD4, SLC6A3
21clozapine44 28 50 1112.4SLC6A3, DRD4
22haloperidol44 50 28 2 1113.4SLC6A3, DRD4
23cocaine44 1110.3SLC6A3, DRD4
245-hydroxytryptamine449.3DRD4, SLC6A3
25nicotine44 28 50 1112.3SLC6A3, DRD4
26valine449.2SLC6A3, DRD4
27gaba449.2SLC6A3, DRD4
28norepinephrine44 24 1111.1DRD4, SLC6A3
29glutamate449.1SLC6A3, DRD4
30dopamine44 28 24 1112.0SLC6A3, DRD4
31sodium44 249.8SLC6A3, DRD4

GO Terms for genes affiliated with Separation Anxiety Disorder

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Cellular components related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.1SLC6A3, DRD4
2neuronal cell bodyGO:0430258.8SLC6A3, DRD4

Biological processes related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:0420539.1SLC6A3, DRD4

Molecular functions related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD4
2dopamine bindingGO:0352408.8SLC6A3, DRD4

Products for genes affiliated with Separation Anxiety Disorder

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  • Antibodies
  • Proteins
  • Lysates

Sources for Separation Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet