MCID: SPR012
MIFTS: 32

Separation Anxiety Disorder malady

Mental diseases category

Summaries for Separation Anxiety Disorder

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards: Separation Anxiety Disorder is related to personality disorder and oppositional defiant disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (dopamine receptor D4), and among its related pathways is Circadian entrainment. The compounds raclopride and piperazine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia:66 Separation anxiety disorder (SAD) is a psychological condition in which an individual experiences... more...

Aliases & Classifications for Separation Anxiety Disorder

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Sources:
9Disease Ontology, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

separation anxiety disorder 9 63


External Ids:

Disease Ontology9 DOID:10685

Related Diseases for Separation Anxiety Disorder

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to separation anxiety disorder

Symptoms for Separation Anxiety Disorder

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Drugs & Therapeutics for Separation Anxiety Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Separation Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Separation Anxiety Disorder

Search NIH Clinical Center for Separation Anxiety Disorder

Search CenterWatch for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

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Anatomical Context for Separation Anxiety Disorder

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Sources:
34MalaCards
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MalaCards organs/tissues related to Separation Anxiety Disorder:

34
Eye

Animal Models for Separation Anxiety Disorder or affiliated genes

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Publications for Separation Anxiety Disorder

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Sources:
53PubMed
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Articles related to Separation Anxiety Disorder:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Patterns of family identification and self-congruence in childhood separation anxiety disorder. (23751201)
2014
2
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
3
Adult separation anxiety disorder in DSM-5. (23673209)
2013
4
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
5
Separation anxiety disorder: lumping or splitting? (23493754)
2013
6
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. (23607501)
2013
7
Looking for balance between promoting adult separation anxiety disorder and overlooking it. (23901151)
2013
8
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. (23963543)
2013
9
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. (23247205)
2013
10
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. (24064331)
2013
11
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. (22922077)
2013
12
DSM-5 allows separation anxiety disorder to grow up. (23293308)
2013
13
Separation anxiety disorder in adults: is the neglect real? (23382511)
2013
14
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. (22542862)
2012
15
Separation anxiety disorder increases among neonatal intensive care unit graduates. (21819341)
2012
16
Temperament and character dimensions of patients with adult separation anxiety disorder. (22440427)
2012
17
Separation anxiety disorder in OCD. (21308883)
2011
18
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. (21309628)
2011
19
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial. (21494062)
2011
20
Early predictors of separation anxiety disorder: early stranger anxiety, parental pathology and prenatal factors. (21847002)
2011
21
Children suffering from separation anxiety disorder (SAD) show increased HPA axis activity compared to healthy controls. (20870248)
2011
22
Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. (20731709)
2010
23
The prevalence and correlates of adult separation anxiety disorder in an anxiety clinic. (20219138)
2010
24
Adult separation anxiety disorder: a disorder comes of age. (20552302)
2010
25
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. (20675099)
2010
26
Adult separation anxiety disorder among war-affected Bosnian refugees: comorbidity with PTSD and associations with dimensions of trauma. (20135680)
2010
27
Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. (19813086)
2010
28
SEPARATION ANXIETY DISORDER IN YOUTH: PHENOMENOLOGY, ASSESSMENT, AND TREATMENT. (19966943)
2008
29
Separation anxiety disorder and school refusal in childhood: potential risk factors for developing distinct psychiatric disorders? (18311428)
2008
30
The unique impact of parent training for separation anxiety disorder in children. (18502252)
2008
31
Separation anxiety disorder in childhood as a risk factor for future mental illness. (18356763)
2008
32
Separation anxiety disorder in a 13-year-old boy managed by the Neuro Emotional Technique as a biopsychosocial intervention. (19646371)
2008
33
Separation anxiety disorder and school refusal in children and adolescents. (16452275)
2006
34
Separation anxiety disorder. (15768687)
2005
35
Asperger's disorder with co-morbid separation anxiety disorder: a case report. (15796129)
2005
36
Separation anxiety disorder, panic disorder, and school refusal. (16171702)
2005
37
Informant disagreement for separation anxiety disorder. (15187805)
2004
38
Risk for separation anxiety disorder among girls: paternal absence, socioeconomic disadvantage, and genetic vulnerability. (15122944)
2004
39
Course and short-term outcomes of separation anxiety disorder in a community sample of twins. (15322414)
2004
40
Separation anxiety disorder in young children: a longitudinal and family analysis. (14710468)
2003
41
Associations between juvenile and adult forms of separation anxiety disorder: a study of adult volunteers with histories of school refusal. (12080215)
2002
42
Comorbidity of dependent personality disorder and separation anxiety disorder in addictive disorders and in healthy subjects. (12239442)
2002
43
Cognitive-behavioral therapy with a six-year-old boy with separation anxiety disorder: a case study. (11378998)
2001
44
Separation anxiety disorder: planning treatment. (10878189)
2000
45
Is there an adult form of separation anxiety disorder? A brief clinical report. (9140640)
1997
46
Understanding separation anxiety disorder. (7795948)
1995
47
Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder. (7653694)
1995
48
Childhood separation anxiety disorder in patients with adult anxiety disorders. (8185008)
1994
49
Boyhood separation anxiety disorder: thought disorder and object relations psychopathology as manifested in Rorschach imagery. (2724040)
1989
50
Expression of separation anxiety disorder: the roles of age and gender. (3436175)
1987

Variations for Separation Anxiety Disorder

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Expression for genes affiliated with Separation Anxiety Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for genes affiliated with Separation Anxiety Disorder

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Sources:
51PathCards, 31KEGG
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Pathways related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1SLC6A3, DRD4

Compounds for genes affiliated with Separation Anxiety Disorder

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1raclopride46 3010.5SLC6A3, DRD4
2piperazine46 1210.5SLC6A3, DRD4
3sulpiride46 30 1211.5SLC6A3, DRD4
4methylphenidate46 52 1211.5SLC6A3, DRD4
5piperidine469.5DRD4, SLC6A3
6maoa469.5SLC6A3, DRD4
7pramipexole46 30 52 1212.5SLC6A3, DRD4
8phencyclidine46 30 1211.5DRD4, SLC6A3
9quinpirole46 3010.5DRD4, SLC6A3
10heroin46 52 1211.5SLC6A3, DRD4
11paroxetine46 52 30 1212.5DRD4, SLC6A3
12apomorphine30 46 1211.5DRD4, SLC6A3
13quetiapine46 52 30 25 1213.5SLC6A3, DRD4
14bromocriptine46 30 1211.5SLC6A3, DRD4
15methamphetamine46 52 1211.4SLC6A3, DRD4
16risperidone46 52 30 62 25 1214.4DRD4, SLC6A3
176-hydroxydopamine469.4SLC6A3, DRD4
18amphetamine46 52 1211.4SLC6A3, DRD4
19olanzapine46 52 30 25 1213.4SLC6A3, DRD4
20levodopa46 1210.4DRD4, SLC6A3
21clozapine46 30 52 1212.4SLC6A3, DRD4
22haloperidol46 52 30 3 1213.4SLC6A3, DRD4
23cocaine46 1210.3SLC6A3, DRD4
245-hydroxytryptamine469.3DRD4, SLC6A3
25nicotine46 30 52 1212.3SLC6A3, DRD4
26valine469.2SLC6A3, DRD4
27gaba469.2SLC6A3, DRD4
28norepinephrine46 25 1211.1DRD4, SLC6A3
29glutamate469.1SLC6A3, DRD4
30dopamine46 30 25 1212.0SLC6A3, DRD4
31sodium46 259.8SLC6A3, DRD4

GO Terms for genes affiliated with Separation Anxiety Disorder

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Sources:
17Gene Ontology
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Cellular components related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.1SLC6A3, DRD4
2neuronal cell bodyGO:0430258.8SLC6A3, DRD4

Biological processes related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:0420539.1SLC6A3, DRD4

Molecular functions related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD4
2dopamine bindingGO:0352408.8SLC6A3, DRD4

Products for genes affiliated with Separation Anxiety Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Separation Anxiety Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet