MCID: SPR012
MIFTS: 30

Separation Anxiety Disorder malady

Summaries for Separation Anxiety Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards: Separation Anxiety Disorder is related to personality disorder and mood disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (dopamine receptor D4), and among its related pathways is Circadian entrainment. The compounds raclopride and piperazine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia:63 Separation anxiety disorder (SAD) is a psychological condition in which an individual experiences... more...

Aliases & Classifications for Separation Anxiety Disorder

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8Disease Ontology, 60UMLS
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Aliases & Descriptions:

separation anxiety disorder 8 60


External Ids:

Disease Ontology8 DOID:10685

Related Diseases for Separation Anxiety Disorder

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to separation anxiety disorder

Clinical Features for Separation Anxiety Disorder

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Drugs & Therapeutics for Separation Anxiety Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Separation Anxiety Disorder

Drug clinical trials:

Search ClinicalTrials for Separation Anxiety Disorder

Search NIH Clinical Center for Separation Anxiety Disorder

Search CenterWatch for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

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Anatomical Context for Separation Anxiety Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Separation Anxiety Disorder:

32
Eye

Animal Models for Separation Anxiety Disorder or affiliated genes

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Publications for Separation Anxiety Disorder

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50PubMed
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Articles related to Separation Anxiety Disorder:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Patterns of family identification and self-congruence in childhood separation anxiety disorder. (23751201)
2014
2
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
3
The separation anxiety hypothesis of panic disorder revisited: a meta-analysis. (23680783)
2013
4
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. (24064331)
2013
5
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. (22922077)
2013
6
DSM-5 allows separation anxiety disorder to grow up. (23293308)
2013
7
Separation anxiety disorder in adults: is the neglect real? (23382511)
2013
8
A randomized controlled trial of the child anxiety multi-day program (cAMP) for separation anxiety disorder. (23053618)
2013
9
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. (22542862)
2012
10
Separation anxiety disorder increases among neonatal intensive care unit graduates. (21819341)
2012
11
Temperament and character dimensions of patients with adult separation anxiety disorder. (22440427)
2012
12
Lifetime mood symptoms and adult separation anxiety in patients with complicated grief and/or post-traumatic stress disorder: a preliminary report. (22436352)
2012
13
Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis. (22461084)
2012
14
Separation anxiety disorder in children: disorder-specific responses to experimental separation from the mother. (21923807)
2012
15
The relationship between adult separation anxiety disorder and complicated grief in a cohort of 454 outpatients with mood and anxiety disorders. (22832169)
2012
16
Separation anxiety disorder in OCD. (21308883)
2011
17
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. (21309628)
2011
18
Early predictors of separation anxiety disorder: early stranger anxiety, parental pathology and prenatal factors. (21847002)
2011
19
Children suffering from separation anxiety disorder (SAD) show increased HPA axis activity compared to healthy controls. (20870248)
2011
20
Adult separation anxiety disorder: a disorder comes of age. (20552302)
2010
21
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. (20675099)
2010
22
Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. (19813086)
2010
23
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? (19728570)
2009
24
Forced choice reaction time paradigm in children with separation anxiety disorder, social phobia, and nonanxious controls. (19733835)
2009
25
SEPARATION ANXIETY DISORDER IN YOUTH: PHENOMENOLOGY, ASSESSMENT, AND TREATMENT. (19966943)
2008
26
Separation anxiety disorder and school refusal in childhood: potential risk factors for developing distinct psychiatric disorders? (18311428)
2008
27
The unique impact of parent training for separation anxiety disorder in children. (18502252)
2008
28
Separation anxiety disorder in childhood as a risk factor for future mental illness. (18356763)
2008
29
Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. (18483136)
2008
30
Asperger's disorder with co-morbid separation anxiety disorder: a case report. (15796129)
2005
31
Separation anxiety disorder, panic disorder, and school refusal. (16171702)
2005
32
Informant disagreement for separation anxiety disorder. (15187805)
2004
33
Separation anxiety disorder in young children: a longitudinal and family analysis. (14710468)
2003
34
Is childhood separation anxiety disorder a predictor of adult panic disorder and agoraphobia? A seven-year longitudinal study. (14627883)
2003
35
Rapid resolution of social anxiety disorder, selective mutism, and separation anxiety with paroxetine in an 8-year-old girl. (11944508)
2002
36
Parenting received in childhood and early separation anxiety in male conscripts with adjustment disorder. (11799809)
2002
37
Comorbidity of dependent personality disorder and separation anxiety disorder in addictive disorders and in healthy subjects. (12239442)
2002
38
Relationship between separation anxiety disorder, parental panic disorder, and atopic disorders in children: a controlled high-risk study. (12162630)
2002
39
Genetic and environmental influences on separation anxiety disorder symptoms and their moderation by age and sex. (11777169)
2001
40
Dysfunctional cognitions in children with social phobia, separation anxiety disorder, and generalized anxiety disorder. (10834771)
2000
41
Parental representations associated with adult separation anxiety and panic disorder--agoraphobia. (10442800)
1999
42
Is there an adult form of separation anxiety disorder? A brief clinical report. (9140640)
1997
43
Traits of separation anxiety in boys with gender identity disorder. (8682760)
1996
44
Understanding separation anxiety disorder. (7795948)
1995
45
Is early separation anxiety a specific precursor of panic disorder-agoraphobia? A community study. (7675927)
1995
46
Childhood separation anxiety disorder in patients with adult anxiety disorders. (8185008)
1994
47
Imipramine treatment of children with separation anxiety disorder. (1347039)
1992
48
The prevalence of overanxious disorder and separation anxiety disorder: results from the Ontario Child Health Study. (2228929)
1990
49
Boyhood separation anxiety disorder: thought disorder and object relations psychopathology as manifested in Rorschach imagery. (2724040)
1989
50
Behavior therapy for separation anxiety disorder. (3069093)
1988

Genetic Variations for Separation Anxiety Disorder

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Expression for genes affiliated with Separation Anxiety Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for genes affiliated with Separation Anxiety Disorder

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29KEGG
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Pathways related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1SLC6A3, DRD4

Compounds for genes affiliated with Separation Anxiety Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1raclopride44 2810.5SLC6A3, DRD4
2piperazine44 1110.5DRD4, SLC6A3
3sulpiride44 28 1111.5DRD4, SLC6A3
4methylphenidate44 49 1111.5DRD4, SLC6A3
5piperidine449.5SLC6A3, DRD4
6maoa449.5DRD4, SLC6A3
7pramipexole44 49 28 1112.5SLC6A3, DRD4
8phencyclidine44 28 1111.5DRD4, SLC6A3
9quinpirole44 2810.5SLC6A3, DRD4
10heroin44 49 1111.5DRD4, SLC6A3
11paroxetine44 49 28 1112.5DRD4, SLC6A3
12apomorphine44 28 1111.5SLC6A3, DRD4
13quetiapine44 49 28 11 2413.5SLC6A3, DRD4
14risperidone28 44 49 59 11 2414.4SLC6A3, DRD4
15bromocriptine28 44 1111.4DRD4, SLC6A3
16methamphetamine44 49 1111.4SLC6A3, DRD4
176-hydroxydopamine449.4DRD4, SLC6A3
18amphetamine44 1110.4DRD4, SLC6A3
19olanzapine49 44 28 11 2413.4DRD4, SLC6A3
20levodopa44 1110.4SLC6A3, DRD4
21clozapine44 28 49 1112.4DRD4, SLC6A3
22haloperidol44 28 2 49 1113.3DRD4, SLC6A3
23cocaine44 1110.3SLC6A3, DRD4
245-hydroxytryptamine449.3DRD4, SLC6A3
25nicotine44 49 28 1112.2SLC6A3, DRD4
26valine449.2SLC6A3, DRD4
27gaba449.1SLC6A3, DRD4
28sodium44 2410.1DRD4, SLC6A3
29norepinephrine44 11 2411.0DRD4, SLC6A3
30dopamine44 28 11 2411.8DRD4, SLC6A3

GO Terms for genes affiliated with Separation Anxiety Disorder

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16Gene Ontology
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Cellular components related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.1SLC6A3, DRD4

Biological processes related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:0420539.1SLC6A3, DRD4

Molecular functions related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD4
2dopamine bindingGO:0352408.8SLC6A3, DRD4

Products for genes affiliated with Separation Anxiety Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Separation Anxiety Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet