MCID: SPR012
MIFTS: 39

Separation Anxiety Disorder

Categories: Mental diseases

Aliases & Classifications for Separation Anxiety Disorder

MalaCards integrated aliases for Separation Anxiety Disorder:

Name: Separation Anxiety Disorder 12 72 14 69
Separation Anxiety Disorder of Childhood 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10685
ICD10 32 F93.0

Summaries for Separation Anxiety Disorder

Disease Ontology : 12 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards based summary : Separation Anxiety Disorder, also known as separation anxiety disorder of childhood, is related to anxiety and dependent personality disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (Dopamine Receptor D4). The drugs Sertraline and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain and eye, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 72 Separation anxiety disorder (SAD), is an anxiety disorder in which an individual experiences excessive... more...

Related Diseases for Separation Anxiety Disorder

Diseases related to Separation Anxiety Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 anxiety 31.1 OXT SLC6A3 TSPO
2 dependent personality disorder 29.7 DRD4 LTBP3 RTN4
3 obsessive-compulsive disorder 29.4 DRD4 OXT PRL SLC6A3
4 autism spectrum disorder 29.2 DRD4 HTR7 OXT OXTR SLC6A3
5 phenytoin or carbamazepine toxicity 10.3 HLA-A HLA-B
6 delusional disorder 10.3 DRD4 HLA-A
7 conduct disorder 10.3 DRD4 OXTR SLC6A3
8 postherpetic neuralgia 10.3 HLA-A HLA-B
9 phobic disorder 10.3 NBAS PIR
10 atrial tachyarrhythmia with short pr interval 10.3 HLA-A HLA-B
11 glaucomatocyclitic crisis 10.3 HLA-A HLA-B
12 pars planitis 10.3 HLA-A HLA-B
13 panic disorder 10.2
14 pityriasis rosea 10.2 HLA-A HLA-B
15 substance abuse 10.2 DRD4 PRL SLC6A3
16 aging 10.2
17 anterior uveitis 10.2 HLA-A HLA-B
18 chronic pyelonephritis 10.0 HLA-A HLA-B
19 migraine with or without aura 1 10.0 DRD4 HTR7 SLC6A3
20 psychotic disorder 10.0 DRD4 HLA-A PRL SLC6A3
21 social phobia 10.0
22 agoraphobia 10.0
23 dysthymic disorder 9.9 HTR7 PIR
24 generalized anxiety disorder 9.9
25 personality disorder 9.9
26 pedophilia 9.8 OXT PRL RTN4
27 paraphilia disorder 9.8 OXT PRL RTN4
28 kleine-levin hibernation syndrome 9.8 CORT HTR7 SLC6A3
29 autism 9.7
30 phobia, specific 9.7
31 oppositional defiant disorder 9.7
32 allergic hypersensitivity disease 9.7
33 mood disorder 9.7
34 major depressive disorder 9.7 DRD4 OXT OXTR PRL SLC6A3
35 specific developmental disorder 9.6 DRD4 HTR7 OXT RTN4 SLC6A3
36 disease of mental health 9.4 DRD4 HTR7 OXT OXTR RTN4 SLC6A3
37 schizophrenia 9.4 DRD4 HTR7 PRL RTN4 SLC6A3 TSPO
38 mental depression 9.2 CORT HTR7 OXT RTN4

Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to Separation Anxiety Disorder

Symptoms & Phenotypes for Separation Anxiety Disorder

MGI Mouse Phenotypes related to Separation Anxiety Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 CGAS CORT DRD4 GTF2I HTR7 LTBP3
2 endocrine/exocrine gland MP:0005379 9.76 CORT GTF2I OXT OXTR PRL PTPRF
3 growth/size/body region MP:0005378 9.7 GTF2I LTBP3 OXT OXTR PHGDH PIR
4 nervous system MP:0003631 9.36 DRD4 EPRS GTF2I HTR7 OXT OXTR

Drugs & Therapeutics for Separation Anxiety Disorder

Drugs for Separation Anxiety Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sertraline Approved Phase 4 79617-96-2 68617
2
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
3
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
4
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
5 Antidepressive Agents Phase 4,Phase 3,Phase 1
6 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
8 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1
9
Serotonin Phase 4,Phase 3,Phase 1 50-67-9 5202
10 Serotonin Agents Phase 4,Phase 3,Phase 1
11 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 1
12 Peripheral Nervous System Agents Phase 4,Phase 1
13 Adrenergic Agents Phase 4,Phase 2
14 Adrenergic Agonists Phase 4,Phase 2
15 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2
16 Adrenergic alpha-Agonists Phase 4,Phase 2
17 Analgesics Phase 4
18 Analgesics, Non-Narcotic Phase 4
19 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
20 Hypnotics and Sedatives Phase 4,Phase 2
21 Adjuvants, Anesthesia Phase 4,Phase 2
22 Anesthetics Phase 4,Phase 2
23 Anesthetics, General Phase 4,Phase 2
24 Anesthetics, Intravenous Phase 4,Phase 2
25 Anti-Anxiety Agents Phase 4,Phase 3,Phase 2
26 GABA Agents Phase 4,Phase 2
27 GABA Modulators Phase 4,Phase 2
28 Tranquilizing Agents Phase 4,Phase 3,Phase 2
29 Anesthetics, Dissociative Phase 4
30 Excitatory Amino Acid Antagonists Phase 4
31 Excitatory Amino Acids Phase 4
32 Serotonin 5-HT1 Receptor Agonists Phase 4
33 Vilazodone Hydrochloride Phase 4 163521-08-2
34
Fluvoxamine Approved, Investigational Phase 3 54739-18-3 5324346 3404
35
Dopamine Approved Phase 2, Phase 3 51-61-6, 62-31-7 681
36
Ethanol Approved Phase 2, Phase 3 64-17-5 702
37
Methylphenidate Approved, Investigational Phase 2, Phase 3 20748-11-2, 113-45-1 4158
38
2-Phenylethanol Experimental Phase 2, Phase 3 60-12-8 6054
39 Antidepressive Agents, Second-Generation Phase 3,Phase 1
40 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
41 Cytochrome P-450 Enzyme Inhibitors Phase 3
42 Anti-Infective Agents Phase 2, Phase 3
43 Anti-Infective Agents, Local Phase 2, Phase 3
44 Central Nervous System Stimulants Phase 2, Phase 3
45 Disinfectants Phase 2, Phase 3
46 Dopamine Agents Phase 2, Phase 3
47 Dopamine Uptake Inhibitors Phase 2, Phase 3
48
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
49 Antihypertensive Agents Phase 2
50
Citalopram Approved Phase 1 59729-33-8 2771

Interventional clinical trials:

(show top 50) (show all 52)

# Name Status NCT ID Phase Drugs
1 Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents Completed NCT01160588 Phase 4 Sertraline
2 Dexmedetomidine Premedication in Children Completed NCT03174678 Phase 4 Dexmedetomidine
3 Oral Dexmedetomidine vs Midazoam For Premedication Completed NCT03357718 Phase 4 Precedex;Midazolam
4 Intranasal Dexmedetomidine vs Midazolam-ketamine Combination for Premedication of Pediatric Patients Completed NCT02072083 Phase 4 Dexmedetomidine;Ketamine
5 Ketamine Infusion for Adolescent Depression and Anxiety Recruiting NCT02579928 Phase 4 Ketamine;Midazolam
6 Vilazodone for Separation Anxiety Disorder Active, not recruiting NCT01999920 Phase 4 Vilazodone;Placebo
7 Computerized Cognitive Behavioral Therapy for Childhood Anxiety in Community Health Centers Completed NCT01416805 Phase 3
8 Treatment for Anxiety in Children Completed NCT00000389 Phase 3 Fluvoxamine
9 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
10 A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder Completed NCT00922636 Phase 2, Phase 3 LY2216684;Methylphenidate;Placebo (tablet);Placebo (capsule)
11 Psychotherapy for Anxiety in Children With Autism Spectrum Disorder Active, not recruiting NCT02028247 Phase 3
12 Treatment Study for Rural Latino Youth With Anxiety Unknown status NCT01491880 Phase 1, Phase 2
13 SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP) Completed NCT01470469 Phase 2 SPD503 (extended-release Guanfacine hydrochloride);Placebo
14 Modular Cognitive Behavioral Therapy for the Treatment of Child Anxiety Disorders in Elementary School Settings Completed NCT00569829 Phase 2
15 Effectiveness of Cognitive Behavioral Therapy (CBT) for Child Anxiety Disorders in Community Clinics in Norway Completed NCT00735995 Phase 2
16 Effects of Parental Behavior on Child Anxiety Regulation Completed NCT00593515 Phase 2
17 Effectiveness Study of CBT for Anxiety in Children Completed NCT00586586 Phase 2
18 A GameBoy as a Distraction Before Surgery in Children Completed NCT00176670 Phase 2 midazolam or GameBoy or parental presence
19 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
20 Cipralex® for Anxiety Disorders in Adolescents Unknown status NCT01293838 Phase 1 Cipralex®
21 A Research Study of How Teens With and Without an Anxiety Disorder Make Decisions Completed NCT00104195 Phase 1
22 Combination of Active or Placebo Attentional Bias Modification Treatment (ABMT) to Either Cognitive Behavioral Group Therapy (CBGT) or Psychoeducational Control Intervention (PCI) for Anxiety Disorders in Children Unknown status NCT01687764
23 Comorbidity Between Balance and Childhood Anxiety Unknown status NCT00599742
24 Effectiveness of Music Therapy Unknown status NCT01040611
25 Assessing Different Methods of Anxiety Care in Pediatric Settings Unknown status NCT00769925
26 TAFF-Psychological Treatment of Separation Anxiety Disorder Completed NCT00255112
27 Internet-delivered Treatment for Children With Anxiety Disorders in a Rural Area; an Open Trial in a Clinical Setting Completed NCT02306356
28 Transdisciplinary Studies of CBT for Anxiety in Youth: Child Anxiety Treatment Study Completed NCT00774150
29 Sleep, Mood, and Behavior Study Completed NCT00787397
30 Internet-delivered Cognitive Behavior Therapy (CBT) for Children Age 8-12 Years With Anxiety Disorders Completed NCT01533402
31 Ventilatory Physiology in Children at Risk for Anxiety Completed NCT00101777
32 Reward-Related Processes and Brain Function Completed NCT00029588
33 Cartoon Distraction and Parental Presence on Anxiety in Pediatric Anesthesia Completed NCT02027844
34 The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery Completed NCT02916407 Sevoflurane;Desflurane
35 Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety Completed NCT01919970
36 Computer- Assisted Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01565629
37 Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism Completed NCT01563003
38 CO2 Inhalation and Risk for Panic Disorder Completed NCT00930657
39 Youth Mayo Clinic Anxiety Coach Pilot Study Completed NCT02205177
40 Investigating the Effects of Parent Component to Cognitive Behavior Therapy (CBT) for Youth With Anxiety Disorders Recruiting NCT02160444
41 Sleep, Nutrition and Psychological Functioning in Kindergarten Children Recruiting NCT02069249
42 Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment Recruiting NCT02305537
43 Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety Recruiting NCT02810171
44 Acoustic Neuromodulation (ANM) for Youth With Anxiety Disorders Active, not recruiting NCT02572973
45 Treatment of Pediatric Anxiety Disorders by Predicting Treatment Response Through Biocellular Markers and Sleep Active, not recruiting NCT02189213 Sertraline;Fluoxetine;Escitalopram
46 A Pilot Study of Fear Extinction Learning in Anxious Youth Active, not recruiting NCT03032926
47 Internet-Based CBT for Children With Anxiety Disorders: Implementation in Clinical Settings Active, not recruiting NCT02350257
48 Coaching for Confidence: Evaluating an Internet-based Program to Help Parents Help Children With Difficulty With Anxiety Active, not recruiting NCT02705261
49 Attention Bias Modification Treatment for Anxious Youth Active, not recruiting NCT01979263
50 Pediatric Anxiety Intervention With an Entertaining Video Game: Feasibility Study Active, not recruiting NCT02713425

Search NIH Clinical Center for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

Anatomical Context for Separation Anxiety Disorder

MalaCards organs/tissues related to Separation Anxiety Disorder:

38
Brain, Eye

Publications for Separation Anxiety Disorder

Articles related to Separation Anxiety Disorder:

(show top 50) (show all 87)
# Title Authors Year
1
Adult separation anxiety disorder in complicated grief: an exploratory study on frequency and correlates. ( 27683967 )
2017
2
A randomized controlled pilot trial of vilazodone for adult separation anxiety disorder. ( 29071764 )
2017
3
Associations of adult separation anxiety disorder with conflict-related trauma, ongoing adversity, and the psychosocial disruptions of mass conflict among West Papuan refugees. ( 26752442 )
2016
4
Separation Anxiety Disorder in School-Age Children: What Health Care Providers Should Know. ( 28012800 )
2016
5
Can separation anxiety disorder escape its attachment to childhood? ( 27265693 )
2016
6
Why are we still missing adult separation anxiety disorder in clinical practice? ( 27343899 )
2016
7
The DSM-5 Dimensional Anxiety Scales in a Dutch non-clinical sample: psychometric properties including the adult separation anxiety disorder scale. ( 27378317 )
2016
8
The separation of adult separation anxiety disorder. ( 27503572 )
2016
9
Dependent personality, separation anxiety disorder and other anxiety disorders in OCD. ( 26542617 )
2015
10
Psychopathology among parents of children and adolescents with separation anxiety disorder. ( 25605571 )
2015
11
Separation anxiety disorder from the perspective of DSM-5: clinical investigation among subjects with panic disorder and associations with mood disorders spectrum. ( 25704393 )
2015
12
Adult separation anxiety disorder: accepted but little understood. ( 25572307 )
2015
13
Pediatric-Onset and Adult-Onset Separation Anxiety Disorder Across Countries in the World Mental Health Survey. ( 26046337 )
2015
14
Early-life risk factors for panic and separation anxiety disorder: Insights and outstanding questions arising from human and animal studies of CO2 sensitivity. ( 24793177 )
2014
15
The effective comparison between emotion-focused cognitive behavioral group therapy and cognitive behavioral group therapy in children with separation anxiety disorder. ( 24949029 )
2014
16
The relationships among separation anxiety disorder, adult attachment style and agoraphobia in patients with panic disorder. ( 25218272 )
2014
17
Patterns of family identification and self-congruence in childhood separation anxiety disorder. ( 23751201 )
2014
18
The right amygdalar tumor presenting with symptoms of separation anxiety disorder (SAD): a case report. ( 24593853 )
2014
19
Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates. ( 24908152 )
2014
20
Separation anxiety disorder across the lifespan: DSM-5 lifts age restriction on diagnosis. ( 25453710 )
2014
21
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. ( 23591000 )
2014
22
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. ( 22922077 )
2013
23
Looking for balance between promoting adult separation anxiety disorder and overlooking it. ( 23901151 )
2013
24
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. ( 23963543 )
2013
25
Let's not abandon separation anxiety disorder in adulthood. ( 23901150 )
2013
26
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. ( 24064331 )
2013
27
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. ( 23607501 )
2013
28
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. ( 23247205 )
2013
29
Separation anxiety disorder: lumping or splitting? ( 23493754 )
2013
30
Adult separation anxiety disorder in DSM-5. ( 23673209 )
2013
31
A randomized controlled trial of the child anxiety multi-day program (cAMP) for separation anxiety disorder. ( 23053618 )
2013
32
DSM-5 allows separation anxiety disorder to grow up. ( 23293308 )
2013
33
Separation anxiety disorder in adults: is the neglect real? ( 23382511 )
2013
34
Separation anxiety disorder increases among neonatal intensive care unit graduates. ( 21819341 )
2012
35
Does the vigilance-avoidance gazing behavior of children with separation anxiety disorder change after cognitive-behavioral therapy? ( 22466517 )
2012
36
Separation anxiety disorder in children: disorder-specific responses to experimental separation from the mother. ( 21923807 )
2012
37
Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis. ( 22461084 )
2012
38
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. ( 22542862 )
2012
39
The relationship between adult separation anxiety disorder and complicated grief in a cohort of 454 outpatients with mood and anxiety disorders. ( 22832169 )
2012
40
Temperament and character dimensions of patients with adult separation anxiety disorder. ( 22440427 )
2012
41
Early predictors of separation anxiety disorder: early stranger anxiety, parental pathology and prenatal factors. ( 21847002 )
2011
42
Children suffering from separation anxiety disorder (SAD) show increased HPA axis activity compared to healthy controls. ( 20870248 )
2011
43
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial. ( 21494062 )
2011
44
Separation anxiety disorder in OCD. ( 21308883 )
2011
45
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. ( 21309628 )
2011
46
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. ( 20675099 )
2010
47
Adult separation anxiety disorder among war-affected Bosnian refugees: comorbidity with PTSD and associations with dimensions of trauma. ( 20135680 )
2010
48
Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. ( 20731709 )
2010
49
Adult separation anxiety disorder: a disorder comes of age. ( 20552302 )
2010
50
Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. ( 19813086 )
2010

Variations for Separation Anxiety Disorder

Expression for Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for Separation Anxiety Disorder

GO Terms for Separation Anxiety Disorder

Cellular components related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 DRD4 HLA-A HLA-B HTR7 OXTR PTPRF
2 MHC class I protein complex GO:0042612 8.62 HLA-A HLA-B

Biological processes related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.75 OXT OXTR SLC6A3
2 female pregnancy GO:0007565 9.74 OXT OXTR PRL
3 social behavior GO:0035176 9.65 DRD4 OXT OXTR
4 positive regulation of blood pressure GO:0045777 9.58 OXT OXTR
5 lactation GO:0007595 9.58 OXTR PRL SLC6A3
6 maternal behavior GO:0042711 9.56 OXT OXTR
7 sleep GO:0030431 9.55 OXT OXTR
8 regulation of dopamine metabolic process GO:0042053 9.54 DRD4 SLC6A3
9 response to progesterone GO:0032570 9.54 OXT OXTR TSPO
10 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.52 HLA-A HLA-B
11 positive regulation of uterine smooth muscle contraction GO:0070474 9.51 OXT OXTR
12 sperm ejaculation GO:0042713 9.49 OXT OXTR
13 protection from natural killer cell mediated cytotoxicity GO:0042270 9.46 HLA-A HLA-B
14 negative regulation of gastric acid secretion GO:0060455 9.43 OXT OXTR
15 response to cocaine GO:0042220 9.33 OXT OXTR SLC6A3
16 positive regulation of penile erection GO:0060406 9.32 OXT OXTR
17 positive regulation of norepinephrine secretion GO:0010701 9.26 OXT OXTR
18 response to amphetamine GO:0001975 9.13 DRD4 OXT OXTR
19 regulation of digestive system process GO:0044058 8.62 OXT OXTR

Molecular functions related to Separation Anxiety Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CORT OXT PRL
2 dopamine binding GO:0035240 8.62 DRD4 SLC6A3

Sources for Separation Anxiety Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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