MCID: SPR012
MIFTS: 32

Separation Anxiety Disorder malady

Mental diseases category
Download this MalaCard

Summaries for Separation Anxiety Disorder

About this section
Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Disease Ontology:8 An anxiety disorder that involves the feeling of excessive and inappropriate levels of anxiety over being separated from a person to whom the individual has a strong emotional attachment or place.

MalaCards: Separation Anxiety Disorder is related to personality disorder and oppositional defiant disorder. An important gene associated with Separation Anxiety Disorder is DRD4 (dopamine receptor D4), and among its related pathways is Circadian entrainment. The compounds raclopride and piperazine have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia:65 Separation anxiety disorder (SAD) is a psychological condition in which an individual experiences... more...

Aliases & Classifications for Separation Anxiety Disorder

About this section
Sources:
8Disease Ontology, 62UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

separation anxiety disorder 8 62


External Ids:

Disease Ontology8 DOID:10685

Related Diseases for Separation Anxiety Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Separation Anxiety Disorder:



Diseases related to separation anxiety disorder

Symptoms for Separation Anxiety Disorder

About this section

Drugs & Therapeutics for Separation Anxiety Disorder

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Separation Anxiety Disorder

Search NIH Clinical Center for Separation Anxiety Disorder

Genetic Tests for Separation Anxiety Disorder

About this section

Anatomical Context for Separation Anxiety Disorder

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Separation Anxiety Disorder:

33
Eye

Animal Models for Separation Anxiety Disorder or affiliated genes

About this section

Publications for Separation Anxiety Disorder

About this section
Sources:
52PubMed
See all sources

Articles related to Separation Anxiety Disorder:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Patterns of family identification and self-congruence in childhood separation anxiety disorder. (23751201)
2014
2
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. (23591000)
2014
3
Adult separation anxiety disorder in DSM-5. (23673209)
2013
4
Let's not abandon separation anxiety disorder in adulthood. (23901150)
2013
5
Separation anxiety disorder: lumping or splitting? (23493754)
2013
6
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. (23607501)
2013
7
Looking for balance between promoting adult separation anxiety disorder and overlooking it. (23901151)
2013
8
The Diagnostic Utility of Separation Anxiety Disorder Symptoms: An Item Response Theory Analysis. (23963543)
2013
9
Overlap of symptom domains of separation anxiety disorder in adulthood with panic disorder-agoraphobia. (23247205)
2013
10
Responses to voluntary hyperventilation in children with separation anxiety disorder: implications for the link to panic disorder. (24064331)
2013
11
Beliefs regarding child anxiety and parenting competence in parents of children with separation anxiety disorder. (22922077)
2013
12
DSM-5 allows separation anxiety disorder to grow up. (23293308)
2013
13
Separation anxiety disorder in adults: is the neglect real? (23382511)
2013
14
Hypersensitivity to 35% carbon dioxide in patients with adult separation anxiety disorder. (22542862)
2012
15
Separation anxiety disorder increases among neonatal intensive care unit graduates. (21819341)
2012
16
Temperament and character dimensions of patients with adult separation anxiety disorder. (22440427)
2012
17
Separation anxiety disorder in OCD. (21308883)
2011
18
Brief report--associations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. (21309628)
2011
19
Disorder-specific cognitive-behavioral therapy for separation anxiety disorder in young children: a randomized waiting-list-controlled trial. (21494062)
2011
20
Early predictors of separation anxiety disorder: early stranger anxiety, parental pathology and prenatal factors. (21847002)
2011
21
Children suffering from separation anxiety disorder (SAD) show increased HPA axis activity compared to healthy controls. (20870248)
2011
22
Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder. (20731709)
2010
23
The prevalence and correlates of adult separation anxiety disorder in an anxiety clinic. (20219138)
2010
24
Adult separation anxiety disorder: a disorder comes of age. (20552302)
2010
25
DSM-IV criteria for childhood separation anxiety disorder: informant, age, and sex differences. (20675099)
2010
26
Adult separation anxiety disorder among war-affected Bosnian refugees: comorbidity with PTSD and associations with dimensions of trauma. (20135680)
2010
27
Vigilance and avoidance of threat in the eye movements of children with separation anxiety disorder. (19813086)
2010
28
SEPARATION ANXIETY DISORDER IN YOUTH: PHENOMENOLOGY, ASSESSMENT, AND TREATMENT. (19966943)
2008
29
Separation anxiety disorder and school refusal in childhood: potential risk factors for developing distinct psychiatric disorders? (18311428)
2008
30
The unique impact of parent training for separation anxiety disorder in children. (18502252)
2008
31
Separation anxiety disorder in childhood as a risk factor for future mental illness. (18356763)
2008
32
Separation anxiety disorder in a 13-year-old boy managed by the Neuro Emotional Technique as a biopsychosocial intervention. (19646371)
2008
33
Separation anxiety disorder and school refusal in children and adolescents. (16452275)
2006
34
Separation anxiety disorder. (15768687)
2005
35
Asperger's disorder with co-morbid separation anxiety disorder: a case report. (15796129)
2005
36
Separation anxiety disorder, panic disorder, and school refusal. (16171702)
2005
37
Informant disagreement for separation anxiety disorder. (15187805)
2004
38
Risk for separation anxiety disorder among girls: paternal absence, socioeconomic disadvantage, and genetic vulnerability. (15122944)
2004
39
Course and short-term outcomes of separation anxiety disorder in a community sample of twins. (15322414)
2004
40
Separation anxiety disorder in young children: a longitudinal and family analysis. (14710468)
2003
41
Associations between juvenile and adult forms of separation anxiety disorder: a study of adult volunteers with histories of school refusal. (12080215)
2002
42
Comorbidity of dependent personality disorder and separation anxiety disorder in addictive disorders and in healthy subjects. (12239442)
2002
43
Cognitive-behavioral therapy with a six-year-old boy with separation anxiety disorder: a case study. (11378998)
2001
44
Separation anxiety disorder: planning treatment. (10878189)
2000
45
Is there an adult form of separation anxiety disorder? A brief clinical report. (9140640)
1997
46
Understanding separation anxiety disorder. (7795948)
1995
47
Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder. (7653694)
1995
48
Childhood separation anxiety disorder in patients with adult anxiety disorders. (8185008)
1994
49
Boyhood separation anxiety disorder: thought disorder and object relations psychopathology as manifested in Rorschach imagery. (2724040)
1989
50
Expression of separation anxiety disorder: the roles of age and gender. (3436175)
1987

Variations for Separation Anxiety Disorder

About this section

Expression for genes affiliated with Separation Anxiety Disorder

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Separation Anxiety Disorder

Search GEO for disease gene expression data for Separation Anxiety Disorder.

Pathways for genes affiliated with Separation Anxiety Disorder

About this section
Sources:
50PathCards, 30KEGG
See all sources

Pathways related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1SLC6A3, DRD4

Compounds for genes affiliated with Separation Anxiety Disorder

About this section
Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1raclopride45 2910.5SLC6A3, DRD4
2piperazine45 1110.5SLC6A3, DRD4
3sulpiride45 29 1111.5SLC6A3, DRD4
4methylphenidate45 51 1111.5SLC6A3, DRD4
5piperidine459.5DRD4, SLC6A3
6maoa459.5SLC6A3, DRD4
7pramipexole45 29 51 1112.5SLC6A3, DRD4
8phencyclidine45 29 1111.5DRD4, SLC6A3
9quinpirole45 2910.5DRD4, SLC6A3
10heroin45 51 1111.5SLC6A3, DRD4
11paroxetine45 51 29 1112.5DRD4, SLC6A3
12apomorphine29 45 1111.5DRD4, SLC6A3
13quetiapine45 51 29 24 1113.5SLC6A3, DRD4
14bromocriptine45 29 1111.5SLC6A3, DRD4
15methamphetamine45 51 1111.4SLC6A3, DRD4
16risperidone45 51 29 61 24 1114.4DRD4, SLC6A3
176-hydroxydopamine459.4SLC6A3, DRD4
18amphetamine45 51 1111.4SLC6A3, DRD4
19olanzapine45 51 29 24 1113.4SLC6A3, DRD4
20levodopa45 1110.4DRD4, SLC6A3
21clozapine45 29 51 1112.4SLC6A3, DRD4
22haloperidol45 51 29 3 1113.4SLC6A3, DRD4
23cocaine45 1110.3SLC6A3, DRD4
245-hydroxytryptamine459.3DRD4, SLC6A3
25nicotine45 29 51 1112.3SLC6A3, DRD4
26valine459.2SLC6A3, DRD4
27gaba459.2SLC6A3, DRD4
28norepinephrine45 24 1111.1DRD4, SLC6A3
29glutamate459.1SLC6A3, DRD4
30dopamine45 29 24 1112.0SLC6A3, DRD4
31sodium45 249.8SLC6A3, DRD4

GO Terms for genes affiliated with Separation Anxiety Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058879.1SLC6A3, DRD4
2neuronal cell bodyGO:0430258.8SLC6A3, DRD4

Biological processes related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine metabolic processGO:0420539.1SLC6A3, DRD4

Molecular functions related to Separation Anxiety Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.1SLC6A3, DRD4
2dopamine bindingGO:0352408.8SLC6A3, DRD4

Products for genes affiliated with Separation Anxiety Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Separation Anxiety Disorder

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet