MCID: SPS077
MIFTS: 70

Sepsis malady

Infectious diseases category
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Summaries for Sepsis

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MedlinePlus:33 Sepsis is a serious illness. it happens when your body has an overwhelming immune response to a bacterial infection. the chemicals released into the blood to fight the infection trigger widespread inflammation. this leads to blood clots and leaky blood vessels. they cause poor blood flow, which deprives your body's organs of nutrients and oxygen. in severe cases, one or more organs fail. in the worst cases, blood pressure drops and the heart weakens, leading to septic shock. anyone can get sepsis, but the risk is higher in people with weakened immune systems infants and children the elderly people with chronic illnesses, such as diabetes, aids, cancer, and kidney or liver disease people suffering from a severe burn or physical trauma common symptoms of sepsis are fever, chills, rapid breathing and heart rate, rash, confusion, and disorientation. doctors diagnose sepsis using a blood test to see if the number of white blood cells is abnormal. they also do lab tests that check for signs of infection. people with sepsis are usually treated in hospital intensive care units. doctors try to treat the infection, sustain the vital organs, and prevent a drop in blood pressure. many patients receive oxygen and intravenous fluids. other types of treatment, such as respirators or kidney dialysis, may be necessary. sometimes, surgery is needed to clear up an infection. nih: national institute of general medical sciences

MalaCards based summary: Sepsis is related to disseminated intravascular coagulation and adult respiratory distress syndrome. An important gene associated with Sepsis is CASP12 (caspase 12 (gene/pseudogene)), and among its related pathways are TRAF Pathway and Spinal Cord Injury. The drug gentamicin sulfate pwdr and the compounds anakinra and monosodium urate have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, kidney and liver, and related mouse phenotypes are adipose tissue and respiratory system.

Wikipedia:65 Sepsis (/?s?ps?s/; Greek: ?????, \"putrefaction, decay\") is a potentially fatal whole-body inflammation... more...

Aliases & Classifications for Sepsis

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Sources:
46OMIM, 44Novoseek, 33MedlinePlus, 62UMLS, 25ICD10
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Related Diseases for Sepsis

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Diseases related to Sepsis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 475)
idRelated DiseaseScoreTop Affiliating Genes
1disseminated intravascular coagulation31.5F5, LBP, CD14
2adult respiratory distress syndrome31.2IL8, LBP, IL1R1
3chorioamnionitis31.1IL1RN, CRP, IL8, IL1R1, IL6
4peritonitis31.0CD14, CRP, LBP, IL6
5arthritis31.0SELL, IL6, IL8
6bacteremia31.0LBP, CRP, MBL2, BPI
7pyelonephritis30.9CRP
8neutropenia30.9MBL2, LBP, ITGAM, IL1RN, CSF2
9galactosemia30.8F5, IL6, CRP
10adult-onset still's disease30.8CRP
11respiratory failure30.8IL6, CRP, ITGAM
12meningitis30.8OMP, MBL2, CRP, IL6, IL8, LBP
13bacteriuria30.8CRP
14mediastinitis30.8CRP
15capillary leak syndrome30.8CSF2
16thrombocytopenia30.7CSF2, F5, IL6, IL1R1
17felty's syndrome30.7CSF2
18meningococcemia30.6BPI, F5
19lymphopenia30.6IL6, IL1RN, SELL
20bacterial meningitis30.6CRP, IL8, LBP
21glomerulonephritis30.6MBL2, IL1RN, IL1R1
22appendicitis30.5CRP
23inflammatory bowel disease30.5IL1RN, IL8, IL6
24aortic aneurysm30.4CRP
25leukopenia30.4IL6, CSF2, ITGAM, CRP, BPI
26leukocyte adhesion deficiency30.4ITGAM
27hypertension30.4CRP, CALCA, F5
28septic shock30.4LBP, SELL, BPI, ITGAM, IL1R1, IL1RAPL2
29leukemia30.4CSF2, IL1RAPL2, SELL, ITGAM, IL6, IL1R1
30acute leukemia30.3CD14, ITGAM, CSF2, SELL
31pre-eclampsia30.3F5, ITGAM, IL6, SELL
32bronchopulmonary dysplasia30.2IL8, ITGAM, IL1RN, SELL
33pneumonia30.2LBP, SELL, BPI, ITGAM, IL1RAPL2, IL8
34systemic lupus erythematosus30.1ITGAM, CRP, IL6, MBL2, IL1R1, IL1RAPL2
35tuberculosis30.1SELL, IL1RAPL2, BPI, ITGAM, TREM1, MBL2
36graft versus host disease30.1IL1R1, CSF2, IL1RAPL2, SELL
37neisseria meningitidis infection30.1MBL2, IL1R1, OMP, IL1RN
38eosinophilia30.0ITGAM, IL8, CSF2, CD14, MBL2
39acute pancreatitis30.0CD14, LBP, ITGAM, IL1R1, IL1RAPL2, IL1RN
40asthma30.0MBL2, SELL, ITGAM, IL8, LBP, CSF2
41colitis29.9BPI, IL1RAPL2, IL1RN, IL8, LBP, IL1R1
42myeloma29.8CD14, CSF2, IL6, SELL, ITGAM, IL1RAPL2
43diabetes mellitus29.8CD14, IL1R1, CRP, CALCA, IL6, ITGAM
44cystic fibrosis29.7MBL2, LBP, IL8, IL1R1, ITGAM, BPI
45vasculitis29.7IL1RAPL2, CD14, SELL, CRP, BPI, MBL2
46rheumatoid arthritis29.2LBP, SELL, BPI, ITGAM, IL1R1, IL1RAPL2
47ulcerative colitis29.2SELL, BPI, IL1R1, IL1RAPL2, IL1RN, IL8
48endotheliitis10.6
49periodontitis10.6IL8
50dengue shock syndrome10.6IL1RN

Graphical network of the top 20 diseases related to Sepsis:



Diseases related to sepsis

Symptoms for Sepsis

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Drugs & Therapeutics for Sepsis

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Drug clinical trials:

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Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Sepsis

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Anatomical Context for Sepsis

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MalaCards organs/tissues related to Sepsis:

32
Neutrophil, Kidney, Liver, Lung, Monocytes, Endothelial, Testes, Heart, Brain, Myeloid, T cells, Whole blood, Bone, Skeletal muscle, Bone marrow, Colon, Skin, B cells, Spleen, Small intestine, Thyroid, Prostate, Nk cells, Pituitary, Smooth muscle, Spinal cord, Pancreas, Breast, Placenta, Cardiac myocytes

Animal Models for Sepsis or affiliated genes

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Publications for Sepsis

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Articles related to Sepsis:

(show top 50)    (show all 2907)
idTitleAuthorsYear
1
Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis*. (24196192)
2014
2
Prognostic factors in pediatric sepsis study, from the spanish society of pediatric intensive care. (24413407)
2014
3
Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients. (24413579)
2014
4
Management of sepsis in asplenic patients. (24251238)
2013
5
Current recommendations for diagnosis and management of sepsis and septic shock. (24201922)
2013
6
Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock: an observational study. (23859579)
2013
7
Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock. (23317877)
2013
8
The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation]. (22225506)
2012
9
Proadrenomedullin as a prognostic marker in neonatal sepsis. (22885414)
2012
10
Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia. (21681178)
2012
11
Sepsis in acute myeloid leukaemia patients receiving high-dose chemotherapy: no impact of chitotriosidase and mannose-binding lectin polymorphisms. (20331735)
2010
12
Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. (20079455)
2010
13
Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients. (20835611)
2010
14
Decreased paraoxonase activity in critically ill patients with sepsis. (19760042)
2010
15
Vipera aspis venom reduces lethality and down-regulates tumor necrosis factor-alpha in a rat model of LPS-induced sepsis. (20034812)
2010
16
Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis. (19482841)
2009
17
Association of mitochondrial allele 4216C with increased risk for complicated sepsis and death after traumatic injury. (19276764)
2009
18
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. (19181857)
2009
19
Therapeutic potential of HMGB1-targeting agents in sepsis. (18980707)
2008
20
Peroxisome proliferator-activated receptor gamma (PPAR gamma) and sepsis. (17277894)
2007
21
Evidence for intestinal and liver epithelial cell injury in the early phase of sepsis. (17607153)
2007
22
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. (17448250)
2007
23
Activated protein C in sepsis and beyond: update 2006. (17127435)
2007
24
Bactericidal permeability increasing protein gene variants in children with sepsis. (17898994)
2007
25
Monocyte response and regulatory effect of emodin and shenmai injection on it in patients with severe sepsis]. (17569361)
2006
26
Effect of fluid resuscitation on adhesion molecule and hemodynamics in patients with severe sepsis]. (16959151)
2006
27
The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. (16497969)
2006
28
Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: its use with CpG adjuvant and potential mechanisms. (16288370)
2005
29
Rapid alterations in transferrin sialylation during sepsis. (15988320)
2005
30
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
31
Clinical experience with drotrecogin alfa in treating gram-positive and -negative pathogens in patients with severe sepsis. (15651264)
2004
32
Protein C/activated protein C pathway: overview of clinical trial results in severe sepsis. (15118517)
2004
33
Serum interleukin-6 level as a diagnostic test in children with sepsis. (14649675)
2003
34
Lipopolysaccharide-binding protein serum levels in patients with severe sepsis due to gram-positive and fungal infections. (12552453)
2003
35
Comparison of procalcitonin, interleukin-6 and C-reactive protein in the differential diagnosis of patients with sepsis syndrome in intensive care units]. (12931436)
2003
36
Fatal case of inhalational anthrax mimicking intra-abdominal sepsis. (12071107)
2002
37
Quantification of antithrombin isoform proportions in plasma samples of healthy subjects, sepsis patients, and in antithrombin concentrates. (12372930)
2002
38
C-reactive protein concentrations during initial (empiric) treatment of neonatal sepsis]. (15637985)
2001
39
Antimicrobial peptides/proteins--application to the therapy of sepsis]. (10586550)
1999
40
Expression of heat shock protein 70 in leukocytes of patients with sepsis. (10085413)
1999
41
Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis. (10446818)
1999
42
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure. (9631803)
1998
43
Nitric oxide in sepsis and endotoxaemia. (9511084)
1998
44
Effect of recombinant human growth hormone on hypoalbuminemia in peritoneal sepsis: experimental and clinical research]. (10923500)
1998
45
Altered monocyte calcium dynamics in sepsis. (9191671)
1997
46
Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. (8985204)
1997
47
Alterations in coagulation and fibrinolysis during sepsis. (8696988)
1996
48
Monocyte tumor necrosis factor receptor levels as a predictor of risk in human sepsis. (8615732)
1996
49
Detection of postoperative sepsis in infants with the use of metabolic stress monitoring. (8154970)
1994
50
Interleukin-8 in sepsis: relation to shock and inflammatory mediators. (1612748)
1992

Variations for Sepsis

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Expression for genes affiliated with Sepsis

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Expression patterns in normal tissues for genes affiliated with Sepsis

Search GEO for disease gene expression data for Sepsis.

Pathways for genes affiliated with Sepsis

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Pathways related to Sepsis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0LBP, CD14
29.9IL6, IL8, IL1R1
39.9IL6, IL8, IL1RN
4
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.9ITGAM, CRP, MBL2
59.9CD14, MBL2, ITGAM
69.9CSF2, IL6, IL8
79.9CSF2, IL6, IL8
89.8LBP, IL6, CRP
99.7CD14, IL6, IL8, ITGAM
109.7CD14, IL6, IL8, ITGAM
11
Show member pathways
9.7TREM1, ITGAM, SELL
12
Show member pathways
9.7CSF2, IL6, IL1RN, IL1R1
13
Show member pathways
9.7IL1R1, IL1RN, IL6, CSF2
149.7LBP, IL1R1, IL8, CD14
159.6CD14, IL6, ITGAM, LBP
16
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.6IL1R1, IL1RN, IL8, IL6, CD14
17
Show member pathways
9.5IL1R1, IL8, IL6, CSF2, CD14
189.5ITGAM, IL8, IL6, CSF2, CD14
19
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.5LBP, IL8, IL6, CASP12, CD14
20
Show member pathways
9.5ITGAM, IL1R1, IL8, IL6, CSF2
219.5ITGAM, IL1R1, IL6, CSF2, CD14
22
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5CD14, IL6, IL8, IL1R1, LBP
23
Show member pathways
Immune response MIF in innate immunity response60
9.5LBP, IL1R1, IL8, IL6, CD14
24
Show member pathways
9.4LBP, IL1R1, CD14, TREM1
25
Show member pathways
9.4LBP, IL8, IL6, CSF2, CD14
26
Show member pathways
9.4LBP, IL8, IL6, CSF2, CD14
279.3CD14, CSF2, IL6, IL8, IL1R1, ITGAM

Compounds for genes affiliated with Sepsis

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Compounds related to Sepsis according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1anakinra44 1110.8IL1RAPL2, IL1RN, IL6, CRP, IL1R1
2monosodium urate449.7CSF2, IL1RAPL2, IL1R1, IL8
3cellulose449.7IL1R1, ITGAM, BPI, LBP, CD14
4adalimumab44 50 1111.6IL1R1, IL1RN, IL6, CRP, IL1RAPL2
5sulfasalazine28 44 50 1112.6IL1RN, IL8, CRP, IL1RAPL2, IL1R1
6amphotericin b449.6IL1R1, CSF2, IL1RAPL2, CRP, IL1RN
7gabexate mesilate449.6IL6, IL8, CRP, F5
8etanercept44 50 1111.6IL1R1, IL1RAPL2, IL6, IL8, IL1RN, CRP
9cuprophan449.5SELL, IL1RN, IL1RAPL2, IL1R1, ITGAM, CD14
10ivig449.4IL1RAPL2, IL6, CSF2, CRP, IL1RN, IL1R1
11atorvastatin44 50 28 24 1113.4CRP, IL6, IL1RN, ITGAM, F5, SELL
12polymyxin b449.4MBL2, IL8, IL1RN, BPI, LBP, CD14
13il 10449.3CSF2, IL1RAPL2, IL6, IL8, LBP, IL1R1
14lipoteichoic acid449.2LBP, BPI, IL1R1, CD14, MBL2, IL6
15hydrocortisone44 2 61 1112.2CD14, F5, IL8, CSF2, IL6, CALCA
16peptidoglycan44 2810.2CD14, LBP, OMP, IL1R1, IL1RN, IL8
17methacholine44 50 1111.2CRP, CD14, IL8, CSF2, CALCA
18sb 20358044 6110.2ITGAM, SELL, CSF2, IL6, IL8, IL1RN
19leukotriene b444 61 2411.1ITGAM, SELL, CSF2, IL6, IL8, IL1RN
20simvastatin44 50 61 28 24 1114.1IL1RAPL2, SELL, F5, ITGAM, IL6, IL1RN
21vitamin d449.1MBL2, CALCA, IL1R1, IL1RN, IL6, CSF2
22neopterin449.1CD14, MBL2, CRP, CSF2, IL6, IL8
23prednisolone44 28 1111.1SELL, ITGAM, IL1R1, IL1RAPL2, IL1RN, IL6
24indomethacin44 28 61 1112.0ITGAM, IL1RN, IL6, SELL, IL1R1, IL1RAPL2
25fmlp449.0CD14, CSF2, IL8, IL1RN, IL1RAPL2, ITGAM
26aspirin44 50 28 2412.0SELL, CSF2, IL1RN, IL1RAPL2, F5, CRP
27pentoxifylline44 1110.0CD14, IL8, IL6, IL1RN, IL1RAPL2, IL1R1
28epinephrine44 24 1111.0ITGAM, IL1R1, SELL, IL1RN, CALCA, F5
29norepinephrine44 24 1110.9CD14, IL6, CRP, IL1RAPL2, IL1R1, CSF2
30cyclosporin a44 28 6110.9ITGAM, IL1R1, IL1RAPL2, IL1RN, IL8, IL6
31histamine44 28 2410.9SELL, CD14, CALCA, IL6, IL8, IL1RAPL2
32polysulfone448.9IL1RN, CRP, CD14, IL1RAPL2, IL1R1, ITGAM
33rantes448.8CD14, MBL2, CSF2, SELL, ITGAM, IL1R1
34superoxide44 249.7ITGAM, CD14, MBL2, CSF2, IL8, IL1RN
35pge2448.7CALCA, CD14, ITGAM, CSF2, IL6, SELL
36polysaccharide448.7LBP, SELL, MBL2, ITGAM, CSF2, F5
37fibrinogen448.7F5, MBL2, CD14, CRP, IL6, LBP
38alanine448.5IL1R1, LBP, CD14, CRP, IL6, BPI
39cycloheximide448.5CD14, SELL, ITGAM, IL1R1, IL1RAPL2, IL1RN
40dexamethasone44 50 28 1111.4CD14, IL1RAPL2, IL1RN, IL1R1, ITGAM, SELL
41retinoic acid44 249.4CD14, F5, CSF2, IL1RN, IL1RAPL2, IL1R1
42cholesterol44 28 24 1111.4BPI, ITGAM, IL1R1, LBP, CD14, IL1RAPL2
43heparin44 28 24 1111.3LBP, SELL, F5, CSF2, IL8, IL1R1
44nitric oxide44 24 1110.3CALCA, LBP, BPI, ITGAM, IL1RAPL2, IL1RN
45lactate448.1SELL, CD14, F5, CRP, CALCA, BPI
46serine448.0CD14, MBL2, F5, IL8, IL1RN, IL1RAPL2
47endotoxin448.0LBP, SELL, BPI, ITGAM, IL1R1, IL1RAPL2
48creatinine448.0IL1R1, ITGAM, BPI, SELL, LBP, CD14
49vegf447.9IL1RN, SELL, BPI, ITGAM, IL1R1, CD14
50tyrosine447.6MBL2, LBP, GPR182, SELL, ITGAM, IL1R1

GO Terms for genes affiliated with Sepsis

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Cellular components related to Sepsis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.6CD14, MBL2, IL1R1, LBP
2extracellular spaceGO:0056158.3IL6, IL8, IL1RN, LBP, CSF2, CALCA
3extracellular regionGO:0055768.0TREM1, LBP, IL1R1, IL8, IL6, CSF2
4plasma membraneGO:0058867.8GPR182, SELL, ITGAM, IL1R1, IL1RN, C5AR2

Biological processes related to Sepsis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.4IL6, CRP
2cellular response to lipoteichoic acidGO:07122310.3LBP, CD14
3regulation of inflammatory responseGO:05072710.2CALCA, CASP12, IL1R1
4response to heatGO:00940810.2IL6, CALCA, CD14
5opsonizationGO:00822810.2LBP, CRP, MBL2
6negative regulation of growth of symbiont in hostGO:04413010.2LBP, MBL2
7positive regulation of chemokine productionGO:03272210.1LBP, IL6
8agingGO:00756810.1CRP, CALCA, IL6
9positive regulation of neutrophil chemotaxisGO:09002310.1LBP, IL8
10monocyte chemotaxisGO:00254810.1IL6, CALCA
11toll-like receptor 4 signaling pathwayGO:03414210.0CD14, ITGAM, LBP
12toll-like receptor signaling pathwayGO:00222410.0LBP, ITGAM, CD14
13defense response to Gram-positive bacteriumGO:05083010.0LBP, IL6, CRP, MBL2
14cellular response to lipopolysaccharideGO:0712229.9CD14, CSF2, IL8, LBP
15negative regulation of tumor necrosis factor productionGO:0327209.9LBP, BPI, C5AR2
16response to lipopolysaccharideGO:0324969.9IL6, IL1RN, LBP
17inflammatory responseGO:0069549.9IL8, IL6, CALCA, CRP, CD14
18leukocyte migrationGO:0509009.9TREM1, ITGAM, SELL
19positive regulation of interleukin-8 productionGO:0327579.8LBP, CALCA
20acute-phase responseGO:0069539.8MBL2, CRP, IL6, IL1RN, LBP
21immune responseGO:0069559.7BPI, IL1R1, IL1RN, IL8, CSF2
22innate immune responseGO:0450879.5LBP, ITGAM, MBL2, CD14, TREM1
23blood coagulationGO:0075969.4TREM1, F5, ITGAM, SELL
24cell surface receptor signaling pathwayGO:0071669.4CD14, IL1R1, GPR182

Molecular functions related to Sepsis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor activityGO:00490810.0IL1RAPL2, IL1R1
2lipopolysaccharide bindingGO:0015309.7CD14, BPI, LBP
3lipoteichoic acid bindingGO:0708919.7CD14, LBP
4protein bindingGO:0055157.5LBP, SELL, ITGAM, IL1R1, IL8, IL6

Products for genes affiliated with Sepsis

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Sources for Sepsis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet