MCID: SPS077
MIFTS: 70

Sepsis malady

Infectious diseases category
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Summaries for Sepsis

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34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Sepsis is a serious illness. it happens when your body has an overwhelming immune response to a bacterial infection. the chemicals released into the blood to fight the infection trigger widespread inflammation. this leads to blood clots and leaky blood vessels. they cause poor blood flow, which deprives your body's organs of nutrients and oxygen. in severe cases, one or more organs fail. in the worst cases, blood pressure drops and the heart weakens, leading to septic shock. anyone can get sepsis, but the risk is higher in people with weakened immune systems infants and children the elderly people with chronic illnesses, such as diabetes, aids, cancer, and kidney or liver disease people suffering from a severe burn or physical trauma common symptoms of sepsis are fever, chills, rapid breathing and heart rate, rash, confusion, and disorientation. doctors diagnose sepsis using a blood test to see if the number of white blood cells is abnormal. they also do lab tests that check for signs of infection. people with sepsis are usually treated in hospital intensive care units. doctors try to treat the infection, sustain the vital organs, and prevent a drop in blood pressure. many patients receive oxygen and intravenous fluids. other types of treatment, such as respirators or kidney dialysis, may be necessary. sometimes, surgery is needed to clear up an infection. nih: national institute of general medical sciences

MalaCards: Sepsis, also known as septicemia, is related to septic shock and disseminated intravascular coagulation. An important gene associated with Sepsis is CASP12 (caspase 12 (gene/pseudogene)), and among its related pathways are TRAF Pathway and Spinal Cord Injury. The drug gentamicin sulfate pwdr and the compounds anakinra and monosodium urate have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are adipose tissue and respiratory system.

Wikipedia:65 Sepsis (/?s?ps?s/; Greek: ?????, \"putrefaction, decay\") is a potentially fatal whole-body inflammation... more...

Aliases & Classifications for Sepsis

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47OMIM, 45Novoseek, 34MedlinePlus, 62UMLS, 25ICD10
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Related Diseases for Sepsis

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17GeneCards, 18GeneDecks
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Diseases related to Sepsis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 460)
idRelated DiseaseScoreTop Affiliating Genes
1septic shock31.2LBP, SELL, BPI, ITGAM, IL1R1, IL1RAPL2
2disseminated intravascular coagulation31.1F5, LBP, CD14
3adult respiratory distress syndrome30.8IL8, LBP, IL1R1
4meningitis30.7OMP, MBL2, CRP, IL6, IL8, LBP
5peritonitis30.7CD14, CRP, LBP, IL6
6chorioamnionitis30.7IL1RN, CRP, IL8, IL1R1, IL6
7bacteremia30.7LBP, CRP, MBL2, BPI
8neutropenia30.7MBL2, LBP, ITGAM, IL1RN, CSF2
9pneumonia30.7LBP, SELL, BPI, ITGAM, IL1RAPL2, IL8
10arthritis30.5SELL, IL6, IL8
11pyelonephritis30.5CRP
12leukemia30.4CSF2, IL1RAPL2, SELL, ITGAM, IL6, IL1R1
13galactosemia30.4F5, IL6, CRP
14thrombocytopenia30.3CSF2, F5, IL6, IL1R1
15respiratory failure30.3IL6, CRP, ITGAM
16acute pancreatitis30.2CD14, LBP, ITGAM, IL1R1, IL1RAPL2, IL1RN
17hypertension30.2CRP, CALCA, F5
18meningococcemia30.2BPI, F5
19bacterial meningitis30.1CRP, IL8, LBP
20glomerulonephritis30.1MBL2, IL1RN, IL1R1
21adult-onset still's disease30.1CRP
22mediastinitis30.1CRP
23tuberculosis30.1SELL, IL1RAPL2, BPI, ITGAM, TREM1, MBL2
24capillary leak syndrome30.1CSF2
25leukopenia30.1IL6, CSF2, ITGAM, CRP, BPI
26felty's syndrome30.1CSF2
27systemic lupus erythematosus30.0ITGAM, CRP, IL6, MBL2, IL1R1, IL1RAPL2
28inflammatory bowel disease30.0IL1RN, IL8, IL6
29lymphopenia30.0IL6, IL1RN, SELL
30asthma30.0MBL2, SELL, ITGAM, IL8, LBP, CSF2
31acute leukemia30.0CD14, ITGAM, CSF2, SELL
32pre-eclampsia30.0F5, ITGAM, IL6, SELL
33rheumatoid arthritis29.9LBP, SELL, BPI, ITGAM, IL1R1, IL1RAPL2
34bacteriuria29.9CRP
35appendicitis29.9CRP
36cystic fibrosis29.8MBL2, LBP, IL8, IL1R1, ITGAM, BPI
37aortic aneurysm29.8CRP
38leukocyte adhesion deficiency29.8ITGAM
39paroxysmal nocturnal hemoglobinuria29.8SELL, CD14
40graft versus host disease29.8IL1R1, CSF2, IL1RAPL2, SELL
41neisseria meningitidis infection29.8MBL2, IL1R1, OMP, IL1RN
42myeloma29.7CD14, CSF2, IL6, SELL, ITGAM, IL1RAPL2
43diabetes mellitus29.7CD14, IL1R1, CRP, CALCA, IL6, ITGAM
44vasculitis29.7IL1RAPL2, CD14, SELL, CRP, BPI, MBL2
45ulcerative colitis29.5SELL, BPI, IL1R1, IL1RAPL2, IL1RN, IL8
46endotheliitis10.6
47purpura10.6
48burns10.5
49purpura fulminans10.5
50hepatitis10.5

Graphical network of the top 20 diseases related to Sepsis:



Diseases related to sepsis

Symptoms for Sepsis

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Drugs & Therapeutics for Sepsis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Sepsis

Search NIH Clinical Center for Sepsis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Sepsis

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Anatomical Context for Sepsis

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33MalaCards
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MalaCards organs/tissues related to Sepsis:

33
Liver, Kidney, Lung, Monocytes, Endothelial, Testes, Heart, Brain, Myeloid, T cells, Whole blood, Bone, Skeletal muscle, Bone marrow, Skin, Colon, B cells, Pituitary, Prostate, Small intestine, Thyroid, Spleen, Nk cells, Smooth muscle, Spinal cord, Pancreas, Placenta, Breast, Cardiac myocytes

Animal Models for Sepsis or affiliated genes

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37MGI
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Publications for Sepsis

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52PubMed
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Articles related to Sepsis:

(show top 50)    (show all 2816)
idTitleAuthorsYear
1
Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis*. (24196192)
2014
2
Prognostic factors in pediatric sepsis study, from the spanish society of pediatric intensive care. (24413407)
2014
3
Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients. (24413579)
2014
4
Management of sepsis in asplenic patients. (24251238)
2013
5
Current recommendations for diagnosis and management of sepsis and septic shock. (24201922)
2013
6
Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock: an observational study. (23859579)
2013
7
Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock. (23317877)
2013
8
The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation]. (22225506)
2012
9
Proadrenomedullin as a prognostic marker in neonatal sepsis. (22885414)
2012
10
Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia. (21681178)
2012
11
Sepsis in acute myeloid leukaemia patients receiving high-dose chemotherapy: no impact of chitotriosidase and mannose-binding lectin polymorphisms. (20331735)
2010
12
Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. (20079455)
2010
13
Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients. (20835611)
2010
14
Decreased paraoxonase activity in critically ill patients with sepsis. (19760042)
2010
15
Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis. (19482841)
2009
16
Association of mitochondrial allele 4216C with increased risk for complicated sepsis and death after traumatic injury. (19276764)
2009
17
Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. (19181857)
2009
18
Therapeutic potential of HMGB1-targeting agents in sepsis. (18980707)
2008
19
Peroxisome proliferator-activated receptor gamma (PPAR gamma) and sepsis. (17277894)
2007
20
Evidence for intestinal and liver epithelial cell injury in the early phase of sepsis. (17607153)
2007
21
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. (17448250)
2007
22
Activated protein C in sepsis and beyond: update 2006. (17127435)
2007
23
Bactericidal permeability increasing protein gene variants in children with sepsis. (17898994)
2007
24
Monocyte response and regulatory effect of emodin and shenmai injection on it in patients with severe sepsis]. (17569361)
2006
25
Effect of fluid resuscitation on adhesion molecule and hemodynamics in patients with severe sepsis]. (16959151)
2006
26
The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy. (16497969)
2006
27
Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: its use with CpG adjuvant and potential mechanisms. (16288370)
2005
28
Rapid alterations in transferrin sialylation during sepsis. (15988320)
2005
29
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
30
Clinical experience with drotrecogin alfa in treating gram-positive and -negative pathogens in patients with severe sepsis. (15651264)
2004
31
Protein C/activated protein C pathway: overview of clinical trial results in severe sepsis. (15118517)
2004
32
Serum interleukin-6 level as a diagnostic test in children with sepsis. (14649675)
2003
33
Lipopolysaccharide-binding protein serum levels in patients with severe sepsis due to gram-positive and fungal infections. (12552453)
2003
34
Comparison of procalcitonin, interleukin-6 and C-reactive protein in the differential diagnosis of patients with sepsis syndrome in intensive care units]. (12931436)
2003
35
Fatal case of inhalational anthrax mimicking intra-abdominal sepsis. (12071107)
2002
36
Quantification of antithrombin isoform proportions in plasma samples of healthy subjects, sepsis patients, and in antithrombin concentrates. (12372930)
2002
37
C-reactive protein concentrations during initial (empiric) treatment of neonatal sepsis]. (15637985)
2001
38
Antimicrobial peptides/proteins--application to the therapy of sepsis]. (10586550)
1999
39
Expression of heat shock protein 70 in leukocytes of patients with sepsis. (10085413)
1999
40
Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis. (10446818)
1999
41
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure. (9631803)
1998
42
Nitric oxide in sepsis and endotoxaemia. (9511084)
1998
43
Effect of recombinant human growth hormone on hypoalbuminemia in peritoneal sepsis: experimental and clinical research]. (10923500)
1998
44
Altered monocyte calcium dynamics in sepsis. (9191671)
1997
45
Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. (8985204)
1997
46
Alterations in coagulation and fibrinolysis during sepsis. (8696988)
1996
47
Monocyte tumor necrosis factor receptor levels as a predictor of risk in human sepsis. (8615732)
1996
48
Increased release of soluble tumor necrosis factor receptors into blood during clinical sepsis. (7986165)
1994
49
Detection of postoperative sepsis in infants with the use of metabolic stress monitoring. (8154970)
1994
50
Interleukin-8 in sepsis: relation to shock and inflammatory mediators. (1612748)
1992

Variations for Sepsis

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Expression for genes affiliated with Sepsis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sepsis

Search GEO for disease gene expression data for Sepsis.

Pathways for genes affiliated with Sepsis

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50PathCards, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 57SinoBiological, 30KEGG, 54R&D Systems
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Pathways related to Sepsis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0LBP, CD14
29.9IL6, IL8, IL1R1
39.9IL6, IL8, IL1RN
4
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.9ITGAM, CRP, MBL2
59.9CD14, MBL2, ITGAM
69.9CSF2, IL6, IL8
79.9CSF2, IL6, IL8
89.8LBP, IL6, CRP
99.7CD14, IL6, IL8, ITGAM
109.7CD14, IL6, IL8, ITGAM
11
Show member pathways
9.7TREM1, ITGAM, SELL
12
Show member pathways
9.7CSF2, IL6, IL1RN, IL1R1
13
Show member pathways
9.7IL1R1, IL1RN, IL6, CSF2
149.7LBP, IL1R1, IL8, CD14
159.6CD14, IL6, ITGAM, LBP
16
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.6IL1R1, IL1RN, IL8, IL6, CD14
17
Show member pathways
9.5IL1R1, IL8, IL6, CSF2, CD14
189.5ITGAM, IL8, IL6, CSF2, CD14
19
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.5LBP, IL8, IL6, CASP12, CD14
20
Show member pathways
9.5ITGAM, IL1R1, IL8, IL6, CSF2
219.5ITGAM, IL1R1, IL6, CSF2, CD14
22
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5CD14, IL6, IL8, IL1R1, LBP
23
Show member pathways
Immune response MIF in innate immunity response60
9.5LBP, IL1R1, IL8, IL6, CD14
24
Show member pathways
9.4LBP, IL1R1, CD14, TREM1
25
Show member pathways
9.4LBP, IL8, IL6, CSF2, CD14
26
Show member pathways
9.4LBP, IL8, IL6, CSF2, CD14
279.3CD14, CSF2, IL6, IL8, IL1R1, ITGAM

Compounds for genes affiliated with Sepsis

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Sepsis according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1anakinra45 1110.8IL1RAPL2, IL1RN, IL6, CRP, IL1R1
2monosodium urate459.7CSF2, IL1RAPL2, IL1R1, IL8
3cellulose459.7IL1R1, ITGAM, BPI, LBP, CD14
4adalimumab45 51 1111.6IL1R1, IL1RN, IL6, CRP, IL1RAPL2
5sulfasalazine29 45 51 1112.6IL1RN, IL8, CRP, IL1RAPL2, IL1R1
6amphotericin b459.6IL1R1, CSF2, IL1RAPL2, CRP, IL1RN
7gabexate mesilate459.6IL6, IL8, CRP, F5
8etanercept45 51 1111.6IL1R1, IL1RAPL2, IL6, IL8, IL1RN, CRP
9cuprophan459.5SELL, IL1RN, IL1RAPL2, IL1R1, ITGAM, CD14
10ivig459.4IL1RAPL2, IL6, CSF2, CRP, IL1RN, IL1R1
11atorvastatin45 51 29 24 1113.4CRP, IL6, IL1RN, ITGAM, F5, SELL
12polymyxin b459.4MBL2, IL8, IL1RN, BPI, LBP, CD14
13il 10459.3CSF2, IL1RAPL2, IL6, IL8, LBP, IL1R1
14lipoteichoic acid459.2LBP, BPI, IL1R1, CD14, MBL2, IL6
15hydrocortisone45 3 61 1112.2CD14, F5, IL8, CSF2, IL6, CALCA
16peptidoglycan45 2910.2CD14, LBP, OMP, IL1R1, IL1RN, IL8
17methacholine45 51 1111.2CRP, CD14, IL8, CSF2, CALCA
18sb 20358045 6110.2ITGAM, SELL, CSF2, IL6, IL8, IL1RN
19leukotriene b445 61 2411.1ITGAM, SELL, CSF2, IL6, IL8, IL1RN
20simvastatin45 51 61 29 24 1114.1IL1RAPL2, SELL, F5, ITGAM, IL6, IL1RN
21vitamin d459.1MBL2, CALCA, IL1R1, IL1RN, IL6, CSF2
22neopterin459.1CD14, MBL2, CRP, CSF2, IL6, IL8
23prednisolone45 29 1111.1SELL, ITGAM, IL1R1, IL1RAPL2, IL1RN, IL6
24indomethacin45 29 61 1112.0ITGAM, IL1RN, IL6, SELL, IL1R1, IL1RAPL2
25fmlp459.0CD14, CSF2, IL8, IL1RN, IL1RAPL2, ITGAM
26aspirin45 51 29 2412.0SELL, CSF2, IL1RN, IL1RAPL2, F5, CRP
27pentoxifylline45 1110.0CD14, IL8, IL6, IL1RN, IL1RAPL2, IL1R1
28epinephrine45 24 1111.0ITGAM, IL1R1, SELL, IL1RN, CALCA, F5
29norepinephrine45 24 1110.9CD14, IL6, CRP, IL1RAPL2, IL1R1, CSF2
30cyclosporin a45 29 6110.9ITGAM, IL1R1, IL1RAPL2, IL1RN, IL8, IL6
31histamine45 29 2410.9SELL, CD14, CALCA, IL6, IL8, IL1RAPL2
32polysulfone458.9IL1RN, CRP, CD14, IL1RAPL2, IL1R1, ITGAM
33rantes458.8CD14, MBL2, CSF2, SELL, ITGAM, IL1R1
34superoxide45 249.7ITGAM, CD14, MBL2, CSF2, IL8, IL1RN
35pge2458.7CALCA, CD14, ITGAM, CSF2, IL6, SELL
36polysaccharide458.7LBP, SELL, MBL2, ITGAM, CSF2, F5
37fibrinogen458.7F5, MBL2, CD14, CRP, IL6, LBP
38alanine458.5IL1R1, LBP, CD14, CRP, IL6, BPI
39cycloheximide458.5CD14, SELL, ITGAM, IL1R1, IL1RAPL2, IL1RN
40dexamethasone45 51 29 1111.4CD14, IL1RAPL2, IL1RN, IL1R1, ITGAM, SELL
41retinoic acid45 249.4CD14, F5, CSF2, IL1RN, IL1RAPL2, IL1R1
42cholesterol45 29 24 1111.4BPI, ITGAM, IL1R1, LBP, CD14, IL1RAPL2
43heparin45 29 24 1111.3LBP, SELL, F5, CSF2, IL8, IL1R1
44nitric oxide45 24 1110.3CALCA, LBP, BPI, ITGAM, IL1RAPL2, IL1RN
45lactate458.1SELL, CD14, F5, CRP, CALCA, BPI
46serine458.0CD14, MBL2, F5, IL8, IL1RN, IL1RAPL2
47endotoxin458.0LBP, SELL, BPI, ITGAM, IL1R1, IL1RAPL2
48creatinine458.0IL1R1, ITGAM, BPI, SELL, LBP, CD14
49vegf457.9IL1RN, SELL, BPI, ITGAM, IL1R1, CD14
50tyrosine457.6MBL2, LBP, GPR182, SELL, ITGAM, IL1R1

GO Terms for genes affiliated with Sepsis

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16Gene Ontology
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Cellular components related to Sepsis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.6CD14, MBL2, IL1R1, LBP
2extracellular spaceGO:0056158.3IL6, IL8, IL1RN, LBP, CSF2, CALCA
3extracellular regionGO:0055768.0TREM1, LBP, IL1R1, IL8, IL6, CSF2
4plasma membraneGO:0058867.8GPR182, SELL, ITGAM, IL1R1, IL1RN, C5AR2

Biological processes related to Sepsis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of lipid storageGO:01088810.4IL6, CRP
2cellular response to lipoteichoic acidGO:07122310.3LBP, CD14
3regulation of inflammatory responseGO:05072710.2CALCA, CASP12, IL1R1
4response to heatGO:00940810.2IL6, CALCA, CD14
5opsonizationGO:00822810.2LBP, CRP, MBL2
6negative regulation of growth of symbiont in hostGO:04413010.2LBP, MBL2
7positive regulation of chemokine productionGO:03272210.1LBP, IL6
8agingGO:00756810.1CRP, CALCA, IL6
9positive regulation of neutrophil chemotaxisGO:09002310.1LBP, IL8
10monocyte chemotaxisGO:00254810.1IL6, CALCA
11toll-like receptor 4 signaling pathwayGO:03414210.0CD14, ITGAM, LBP
12toll-like receptor signaling pathwayGO:00222410.0LBP, ITGAM, CD14
13defense response to Gram-positive bacteriumGO:05083010.0LBP, IL6, CRP, MBL2
14cellular response to lipopolysaccharideGO:0712229.9CD14, CSF2, IL8, LBP
15negative regulation of tumor necrosis factor productionGO:0327209.9LBP, BPI, C5AR2
16response to lipopolysaccharideGO:0324969.9IL6, IL1RN, LBP
17inflammatory responseGO:0069549.9IL8, IL6, CALCA, CRP, CD14
18leukocyte migrationGO:0509009.9TREM1, ITGAM, SELL
19positive regulation of interleukin-8 productionGO:0327579.8LBP, CALCA
20acute-phase responseGO:0069539.8MBL2, CRP, IL6, IL1RN, LBP
21immune responseGO:0069559.7BPI, IL1R1, IL1RN, IL8, CSF2
22innate immune responseGO:0450879.5LBP, ITGAM, MBL2, CD14, TREM1
23blood coagulationGO:0075969.4TREM1, F5, ITGAM, SELL
24cell surface receptor signaling pathwayGO:0071669.4CD14, IL1R1, GPR182

Molecular functions related to Sepsis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor activityGO:00490810.0IL1RAPL2, IL1R1
2lipopolysaccharide bindingGO:0015309.7CD14, BPI, LBP
3lipoteichoic acid bindingGO:0708919.7CD14, LBP
4protein bindingGO:0055157.5LBP, SELL, ITGAM, IL1R1, IL8, IL6

Products for genes affiliated with Sepsis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sepsis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet