MCID: SPT004
MIFTS: 45

Septic Arthritis malady

Rare diseases, Bone diseases categories

Aliases & Classifications for Septic Arthritis

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Septic Arthritis, Aliases & Descriptions:

Name: Septic Arthritis 9 41 11
Infectious Arthritis 9 41 32
Acute Suppurative Arthritis Due to Bacteria 60
 
Arthritis, Infectious 60
Arthritis, Bacterial 60
Arthritis Septic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Summaries for Septic Arthritis

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MedlinePlus:32 Most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. infectious arthritis is an infection in the joint. the infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. symptoms of infectious arthritis include intense pain in the joint joint redness and swelling chills and fever inability to move the area with the infected joint one type of infectious arthritis is reactive arthritis. the reaction is to an infection somewhere else in your body. the joint is usually the knee, ankle, or toe. sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. in women, an infection in the vagina can cause the reaction. for both men and women, it can start with bacteria passed on during sex. another form of reactive arthritis starts with eating food or handling something that has bacteria on it. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery.

MalaCards based summary: Septic Arthritis, also known as infectious arthritis, is related to arthritis and pneumonia. An important gene associated with Septic Arthritis is CXCL11 (chemokine (C-X-C motif) ligand 11), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and CXCR3-mediated signaling events. The compounds tarc and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and bone.

Disease Ontology:9 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases:41 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. depending on the type of infection, one or more joints may be affected. certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. in reactive arthritis, joint inflammation develops weeks, months or even years after the infection. reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery. last updated: 3/31/2012

Wikipedia:63 Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis.... more...

Related Diseases for Septic Arthritis

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Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to septic arthritis

Symptoms for Septic Arthritis

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Drugs & Therapeutics for Septic Arthritis

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Drug clinical trials:

Search ClinicalTrials for Septic Arthritis

Search NIH Clinical Center for Septic Arthritis

Genetic Tests for Septic Arthritis

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Anatomical Context for Septic Arthritis

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MalaCards organs/tissues related to Septic Arthritis:

31
Testes, Bone, Skin, Colon, Liver, Cervix, Myeloid

FMA organs/tissues related to Septic Arthritis:

14
Joint

Animal Models for Septic Arthritis or affiliated genes

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Publications for Septic Arthritis

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Articles related to Septic Arthritis:

(show top 50)    (show all 613)
idTitleAuthorsYear
1
The Clinical Usefulness of Polymerase Chain Reaction as a Supplemental Diagnostic Tool in the Evaluation and the Treatment of Children With Septic Arthritis. (25887824)
2015
2
Septic arthritis: a unique complication of nasal septal abscess. (25738728)
2015
3
Three Cases of Postoperative Septic Arthritis Caused by Mycobacterium conceptionense in Shoulder Joints of Immunocompetent Patients. (24391195)
2014
4
The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis. (24308337)
2014
5
Psoas abscess with septic arthritis of the hip: a case report. (25341610)
2014
6
Staphylococcus lugdunensis septic arthritis and epidural abscess in a patient with rheumatoid arthritis receiving anti-tumour necrosis factor therapy. (25205828)
2014
7
A case of unusual Gram-negative bacilli septic arthritis in an immunocompetent patient. (24005465)
2013
8
Septic arthritis: patients with or without isolated infectious agents have similar characteristics. (24318567)
2013
9
Twelve-month outcome following septic arthritis in children. (23531603)
2013
10
Management of septic arthritis following anterior cruciate ligament reconstruction: a review of current practices and recommendations. (24187034)
2013
11
Neonatal hip septic arthritis: ultrasound should not influence decision to aspirate. (23960065)
2013
12
Salmonella septic arthritis of the knees in a patient with systemic lupus erythematosus. (23753601)
2013
13
Treatment of acute septic arthritis. (23439494)
2013
14
Risk of septic arthritis after intra-articular medication: a study of 16,624 injections in Thoroughbred racehorses. (23782019)
2013
15
Selective IgM deficiency in an adult presenting withA Streptococcus pneumoniae septic arthritis. (23523054)
2013
16
MRI findings of treated bacterial septic arthritis. (22430565)
2012
17
Pantoea agglomerans foreign body-induced septic arthritis. (22926215)
2012
18
Septic arthritis of the knee: the use and effect of antibiotics prior to diagnostic aspiration. (22943233)
2012
19
Streptococcus gordonii septic arthritis: two cases and review of literature. (22974507)
2012
20
Gentamicin in combination with ascorbic acid regulates the severity of Staphylococcus aureus infection-induced septic arthritis in mice. (22924656)
2012
21
Septic arthritis. (22100289)
2011
22
Septic arthritis of the adult ankle joint secondary to Salmonella enteritidis: a case report. (21665492)
2011
23
Possible protective role of chloramphenicol in TSST-1 and coagulase-positive Staphylococcus aureus-induced septic arthritis with altered levels of inflammatory mediators. (20658182)
2011
24
The catabolic role of toll-like receptor 2 (TLR-2) mediated by the NF-I_B pathway in septic arthritis. (20740673)
2011
25
Trochanteroplasty to treat sequelae of septic arthritis of the hip in infancy. Case series and review of the literature. (22183446)
2011
26
The use of CRP within a clinical prediction algorithm for the differentiation of septic arthritis and transient synovitis in children. (22058311)
2011
27
Return to sports activity after postoperative septic arthritis in ACL reconstruction. (20959698)
2010
28
Colovesical, coloenteric, colocutaneous fistula, and hip septic arthritis secondary to sigmoid diverticulitis. (20012298)
2010
29
Septic sacroiliitis: an uncommon septic arthritis. (20149323)
2009
30
Post-partum septic arthritis of the knee: a case report. (19829917)
2009
31
Disseminating septic arthritis following hip hemiarthroplasty. (19637515)
2009
32
Bacteroides fragilis: a case study of bacteremia and septic arthritis. (19827405)
2009
33
Polyarticular septic arthritis with bilateral psoas abscesses following acupuncture. (19502468)
2009
34
Chronic lymphoedema complicated by septic arthritis of the hip. (19298275)
2009
35
Results of arthroscopic adhesiolysis and manipulation in the stiff knee secondary to septic arthritis and inflammatory arthritis. (19148646)
2009
36
Analysis of factors influencing prognosis in foals with septic arthritis. (21851707)
2008
37
Septic arthritis in haemodialysis patients: a seven-year multi-centre review. (18453661)
2008
38
Septic arthritis: clinical audits would help optimise the management. (18795395)
2008
39
Evidence-based emergency medicine/rational clinical examination abstract. Septic arthritis in emergency department patients with joint pain: searching for the optimal diagnostic tool. (18294730)
2008
40
Procalcitonin, C-reactive protein, and complement-3a assays in synovial fluid for diagnosing septic arthritis: preliminary results. (18178503)
2008
41
Melioidosis--an unusual cause of septic arthritis. (18506568)
2008
42
Septic arthritis of the distal interphalangeal joint in cattle: comparison of digital amputation and joint resection by solar approach. (17547598)
2007
43
Familial Mediterranean fever mimicking septic arthritis. (15700115)
2005
44
Rat-bite fever presenting with rash and septic arthritis. (16858964)
2005
45
Assessment of the test characteristics of C-reactive protein for septic arthritis in children. (12724603)
2003
46
Mycobacterium kansasii septic arthritis: French retrospective study of 5 years and review. (10585795)
1999
47
Poststreptococcal reactive arthritis mimicking acute septic arthritis: a hospital-based study. (7593582)
1995
48
Treatment of septic arthritis due to Mycobacterium kansasii. (3919820)
1985
49
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
50
Septic arthritis of the hip joint secondary to umbilical artery catheterization associated with transient femoral and sciatic neuropathy. (4365200)
1974

Variations for Septic Arthritis

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Expression for genes affiliated with Septic Arthritis

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Search GEO for disease gene expression data for Septic Arthritis.

Pathways for genes affiliated with Septic Arthritis

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Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CXCL11, CXCR3
29.5CXCR3, CXCL11
3
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.2CXCL11, TLR2
4
Show member pathways
9.1TLR2, DEFB4A
5
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.7CXCL11, TLR2, DEFB4A
6
Show member pathways
8.7CXCR3, CXCL11, TLR2

Compounds for genes affiliated with Septic Arthritis

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Compounds related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tarc439.7CXCR3, CXCL11
2hbd2439.4TLR2, DEFB4A
3hcec439.4DEFB4A, TLR2
4lipoteichoic acid439.4DEFB4A, TLR2
5il 10439.4CXCR3, TLR2
6anti-fungal439.4DEFB4A, TLR2
7peptidoglycan43 2810.3TLR2, DEFB4A
8sp 60012543 5910.1DEFB4A, TLR2
9tacrolimus43 49 1211.1CXCR3, TLR2
10progesterone43 28 59 24 1213.1DEFB4A, CXCL11, CXCR3
11mannose439.0TLR2, DEFB4A
12ccl343 2810.0CXCR3, CXCL11, TLR2
13ccl443 2810.0TLR2, CXCL11, CXCR3
14flagellin43 2810.0CXCR3, TLR2, DEFB4A
15histamine43 28 2410.9CXCR3, TLR2, DEFB4A
16pd 98,059438.9CXCR3, TLR2, DEFB4A
17heparan sulfate43 249.8CXCR3, TLR2
18arginine438.7CXCR3, CXCL11, TLR2
19rantes438.5DEFB4A, TLR2, CXCL11, CXCR3
20dexamethasone43 49 28 1211.5CXCR3, CXCL11, TLR2, DEFB4A
21endotoxin438.3MEFV, CXCR3, TLR2, DEFB4A
22calcium43 49 24 1211.3CXCR3, CXCL11, TLR2, DEFB4A
23tyrosine438.2MEFV, CXCR3, TLR2, DEFB4A

GO Terms for genes affiliated with Septic Arthritis

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Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.1CXCR3, TLR2

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:00308169.7CXCR3, CXCL11
2T cell chemotaxisGO:00108189.6CXCR3, CXCL11
3positive regulation of cAMP-mediated signalingGO:00439509.5CXCR3, CXCL11
4positive regulation of release of sequestered calcium ion into cytosolGO:00512819.4CXCR3, CXCL11
5chemotaxisGO:00069359.1DEFB4A, CXCL11, CXCR3
6negative regulation of interleukin-12 productionGO:00326959.1TLR2, MEFV
7innate immune responseGO:00450878.5MEFV, TLR2, DEFB4A
8immune responseGO:00069558.4DEFB4A, TLR2, CXCL11
9inflammatory responseGO:00069548.3MEFV, CXCR3, CXCL11, TLR2

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:00048729.1CXCR3, TLR2

Products for genes affiliated with Septic Arthritis

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Sources for Septic Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet