MCID: SPT004
MIFTS: 60

Septic Arthritis malady

Summaries for Septic Arthritis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. infectious arthritis is an infection in the joint. the infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. symptoms of infectious arthritis include intense pain in the joint joint redness and swelling chills and fever inability to move the area with the infected joint one type of infectious arthritis is reactive arthritis. the reaction is to an infection somewhere else in your body. the joint is usually the knee, ankle, or toe. sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. in women, an infection in the vagina can cause the reaction. for both men and women, it can start with bacteria passed on during sex. another form of reactive arthritis starts with eating food or handling something that has bacteria on it. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery.

MalaCards: Septic Arthritis, also known as infectious arthritis, is related to arthritis and osteomyelitis. An important gene associated with Septic Arthritis is CXCL11 (chemokine (C-X-C motif) ligand 11), and among its related pathways are Trafficking and processing of endosomal TLR and Osteopontin Signaling. The compounds cycloheximide and asialo gm1 have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and bone, and related mouse phenotypes are respiratory system and tumorigenesis.

Disease Ontology:8 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases:42 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. depending on the type of infection, one or more joints may be affected. certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. in reactive arthritis, joint inflammation develops weeks, months or even years after the infection. reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery. last updated: 3/31/2012

Wikipedia:63 Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis.... more...

Aliases & Classifications for Septic Arthritis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

septic arthritis 8 42 10
infectious arthritis 8 42 33
acute suppurative arthritis due to bacteria 60
arthritis, infectious 60
arthritis septic 44


Related Diseases for Septic Arthritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.0LACTB, CXCR3, MEFV, CRP, TLR3, TLR2
2osteomyelitis31.1CRP, ITGA2, LACTB
3rheumatoid arthritis30.8CCL18, TLR4, TLR2, TLR9, TLR3, CRP
4influenza30.5CCL18, TLR5, TLR9, TLR3, CXCR3, LACTB
5pneumonia30.5CCL18, TLR4, TLR2, TLR5, TLR3, CRP
6lupus erythematosus30.4TLR9
7melioidosis30.4TLR4, TLR2, TLR5
8systemic lupus erythematosus30.4TLR4, TLR2, TLR5, TLR9, CRP, CXCR3
9crohn's disease30.3CRP
10myeloma30.3ITGA2
11leukemia30.3LACTB, CXCR3, TLR2, TLR4
12familial mediterranean fever30.2MEFV, CRP
13otitis media30.2LACTB, TLR2
14mediastinitis30.2CRP
15osteoarthritis30.2TLR2, TLR3, CRP, DEFB4A, CXCR3, PLAU
16glomerulonephritis30.0TLR9
17hepatitis30.0TLR2, TLR3
18brucellosis30.0MEFV, ITGA2
19pulmonary fibrosis30.0PLAU, CXCR3, CCL18
20appendicitis30.0CRP, LACTB
21peritonitis30.0LACTB, MEFV, CRP, TLR2
22hepatitis c30.0TLR4, TLR2, TLR3, CXCR3, CXCL11
23pyelonephritis30.0TLR4, CRP, LACTB
24colon cancer30.0TLR2, TLR5, TLR9, ITGA2, PLAU
25tuberculosis30.0TLR4, TLR2, TLR9, CRP, DEFB4A, TREM1
26pancreatitis29.9CRP
27lyme disease29.9LACTB, TLR2
28meningitis29.9TLR2, CRP, LACTB
29bacterial meningitis29.9LACTB, CRP, TLR2
30pyomyositis10.5
31pseudogout10.5
32reactive arthritis10.4
33transient arthritis10.4
34ankylosis10.4
35synovitis10.4
36gout10.3
37epidural abscess10.3
38osteonecrosis10.2
39bursitis10.2
40multiple myeloma10.2
41neuropathy10.2
42pericarditis10.2
43rheumatic fever10.2
44felty's syndrome10.2
45chickenpox10.2
46blastomycosis10.2
47acute leukemia10.2
48brachial plexus neuropathy10.2
49endocarditis10.2
50otitis externa10.2

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to septic arthritis

Clinical Features for Septic Arthritis

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Drugs & Therapeutics for Septic Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Septic Arthritis

Drug clinical trials:

Search ClinicalTrials for Septic Arthritis

Search NIH Clinical Center for Septic Arthritis

Search CenterWatch for Septic Arthritis

Genetic Tests for Septic Arthritis

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Anatomical Context for Septic Arthritis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Septic Arthritis:

32
Testes, Bone, Skin, Liver, Myeloid, Colon, Cervix

FMA organs/tissues related to Septic Arthritis:

14
Joint

Animal Models for Septic Arthritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Septic Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.8RELA, CXCR3, PLAU
2MP:00020069.6TLR3, TREM1, HUNK, CXCR3
3MP:00053709.2TLR2, TLR5, MEFV, RELA, PLAU, TLR4
4MP:00053978.6TLR4, TLR2, TLR5, TLR9, MEFV, ITGA2
5MP:00053858.5TLR4, TLR2, TLR5, TLR3, CRP, RELA
6MP:00053878.4PLAU, TLR4, TLR2, TLR5, TLR9, TLR3
7MP:00053848.2TLR4, TLR2, TLR5, TLR9, MEFV, ITGA2
8MP:00053768.1TLR3, TLR9, TLR5, TLR2, TLR4, CRP

Publications for Septic Arthritis

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50PubMed
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Articles related to Septic Arthritis:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Septic arthritis: patients with or without isolated infectious agents have similar characteristics. (24318567)
2013
2
Salmonella septic arthritis of the knees in a patient with systemic lupus erythematosus. (23753601)
2013
3
Bilateral knee replacements for treatment of acute septic arthritis in both knees. (23412206)
2013
4
Septic arthritis of the acromioclavicular joint: An uncommon location. (24094429)
2013
5
In this issue - July 2013: Dingoes and sheep don't mix A^ Septic arthritis after joint injections A^ Equine multinodular pulmonary fibrosis A^ Optimal position for ECG measurements A^ Multiple tumours in a dog A^ Dogs and sea hares don't mix either A^ Buruli ulcers in alpacas. (23782017)
2013
6
Osteomyelitis and septic arthritis from infection with Burkholderia pseudomallei: A 20-year prospective melioidosis study from northern Australia. (24403756)
2013
7
Azithromycin in combination with riboflavin decreases the severity of Staphylococcus aureus infection induced septic arthritis by modulating the production of free radicals and endogenous cytokines. (23229721)
2013
8
Septic arthritis of the knee: the use and effect of antibiotics prior to diagnostic aspiration. (22943233)
2012
9
Gentamicin in combination with ascorbic acid regulates the severity of Staphylococcus aureus infection-induced septic arthritis in mice. (22924656)
2012
10
Detection of Legionella bozemanae, a new cause of septic arthritis, by PCR followed by specific culture. (23052316)
2012
11
Septic arthritis of unilateral lumbar facet joint with contiguous abscess, without prior intervention. (22602829)
2012
12
Atraumatic septic arthritis of the elbow in a young immunocompetent host secondary to distant hematogenous spread. (22900248)
2012
13
Loss of a condyle of the femur or tibia following septic arthritis in infancy: problems of management and testing of a hypothesis of pathogenesis. (23904899)
2012
14
Acute pseudo-septic arthritis following viscosuplementation of the knee. (22937184)
2012
15
Evaluation of the modified Albee arthroplasty for femoral head loss secondary to septic arthritis in young children: surgical technique. (21411686)
2011
16
Rapid diagnosis of septic arthritis using 16S rDNA PCR: a comparison of 3 methods. (21396534)
2011
17
Curtobacterium flaccumfaciens septic arthritis following puncture with a Coxspur Hawthorn thorn. (21562106)
2011
18
TMJ ankylosis after neonatal septic arthritis: literature review and two case reports. (20369268)
2011
19
Evidence-based diagnostics: adult septic arthritis. (21843213)
2011
20
Recent trends in adult-onset septic arthritis of the knee and hip: retrospective analysis of patients treated during the past 50A years. (21584725)
2011
21
Causative organisms and their antibiotic resistance patterns for childhood septic arthritis in china between 1989 and 2008. (21410123)
2011
22
Dexamethasone added to antibiotics improved clinical and laboratory outcomes in children with septic arthritis. (22262386)
2011
23
Images in emergency medicine. Woman with hip pain. Septic arthritis. (21353906)
2011
24
Similar erythrocyte sedimentation rate and C-reactive protein sensitivities at the onset of septic arthritis, osteomyelitis, acute rheumatic fever. (21589835)
2010
25
Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis. (19885711)
2010
26
Sequelae of neonatal septic arthritis of hip. (21218759)
2010
27
Mycobacterium kansasii causing septic arthritis and osteomyelitis in a child. (19884872)
2010
28
Septic arthritis and Clostridium septicum: a clue to colon cancer. (20855487)
2010
29
An unusual cause of septic arthritis in a 16-year-old girl. (19417573)
2009
30
Pathologic dislocation of the shoulder secondary to septic arthritis: a case report. (20062648)
2009
31
Native joint septic arthritis caused by Clostridium difficile in an 11-year old with hemoglobin SS disease. (19710591)
2009
32
Septic arthritis of the shoulder following elective termination of pregnancy. (19243978)
2009
33
USA300 is the predominant genotype causing Staphylococcus aureus septic arthritis in children. (19820424)
2009
34
Septic arthritis: current diagnostic and therapeutic algorithm. (18525361)
2008
35
Septic arthritis due to Absidia corymbifera in a patient with HIV-1 infection. (18084717)
2008
36
A particular form of septic arthritis: septic arthritis of facet joint. (18093863)
2008
37
Streptobacillus moniliformis septic arthritis: a clinical entity distinct from rat-bite fever? (17561996)
2007
38
Does this adult patient have septic arthritis? (17405973)
2007
39
Protracted familial mediterranean fever arthritis presenting as septic arthritis. (17387477)
2007
40
Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis. (16697230)
2006
41
Familial Mediterranean fever mimicking septic arthritis. (15700115)
2005
42
Disseminated blastomycosis presenting as oligoarticular septic arthritis in a 12-year-old girl. (15696562)
2005
43
Mycobacterium malmoense septic arthritis. (12504611)
2003
44
Pyomyositis and septic arthritis due to Bacteroides fragilis in an immunocompetent patient. (8589179)
1995
45
Septic arthritis due to Mycobacterium marinum. (7473495)
1995
46
Septic arthritis of the temporomandibular joint complicating otitis externa. (2703778)
1989
47
Diagnosis of pseudogout and septic arthritis. (3664164)
1987
48
Acute pseudogout simulating septic arthritis. (480605)
1979
49
Lithium carbonate therapy for granulocytopenia in a patient with myelofibrosis and septic arthritis. (515774)
1979
50
Septic arthritis of the hip joint secondary to umbilical artery catheterization associated with transient femoral and sciatic neuropathy. (4365200)
1974

Genetic Variations for Septic Arthritis

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Expression for genes affiliated with Septic Arthritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for genes affiliated with Septic Arthritis

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Septic Arthritis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TLR9, TLR3
29.9RELA, PLAU
39.9TLR9, TLR2, TLR4
4
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
9.8TLR2, TLR5, RELA
5
Hide members
9.8RELA, TLR3, TLR4
6
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.8RELA, TLR3, TLR4
79.8TLR4, TLR5, RELA
89.8RELA, TLR2, TLR4
99.7TLR4, RELA, PLAU
109.6TLR4, TLR2, ITGA2, PLAU
11
Hide members
9.6TLR4, TLR2, TLR5, RELA
129.6TLR4, TLR2, TLR5, RELA
13
Hide members
9.6CCL18, RELA, CXCR3, CXCL11
149.6RELA, TLR9, TLR2, TLR4
159.6TLR4, TLR2, TLR5, TLR9, TLR3
16
Hide members
9.6TLR4, TLR2, TLR5, TLR9, TLR3
17
Hide members
9.6TLR4, TLR2, TLR5, TLR9, TLR3
18
Hide members
9.6TLR4, TLR2, TLR5, TLR9, TLR3
19
Hide members
9.5CCL18, ITGA2, CXCR3, CXCL11, PLAU
20
Immune response Bacterial infections in normal airways
9.4TLR4, TLR2, TLR5, DEFB4A, RELA
21
Hide members
9.4TLR4, TLR2, TLR9, TLR3, RELA
229.4TLR4, TLR2, TLR9, TLR3, RELA
239.4TLR4, TLR2, TLR5, TLR9, TLR3, ITGA2
24
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, TREM1
259.3CXCL11, RELA, TLR9, TLR5, TLR2, TLR4
269.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
27
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
28
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
29
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
30
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
31
Hide members
9.1TLR4, TLR2, TLR5, TLR9, TLR3, RELA
32
Hide members
8.8CCL18, TLR4, TLR2, TLR5, TLR9, TLR3
33
Hide members
8.6TLR4, TLR2, TLR5, TLR9, TLR3, MEFV

Compounds for genes affiliated with Septic Arthritis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Septic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5TLR2
2asialo gm14410.5TLR5, TLR2
3arabinogalactan4410.4TLR2, TLR4
4diaminopimelic acid4410.4TLR2, TLR4
5pam2csk45910.3TLR4, TLR2, TLR3
6pam3csk45910.3TLR4, TLR2, TLR3
7poly(i:c)5910.3TLR4, TLR2, TLR3
8hbd24410.3TLR4, TLR2, DEFB4A
9glucuronoxylomannan4410.3TLR2, TLR4
10imiquimod44 28 59 1113.3TLR3, TLR2, TLR4
11muramyl dipeptide44 2811.3TLR2, TLR4
12endotoxin4410.2TLR3, MEFV, DEFB4A, CXCR3
13il 104410.2CXCR3, TLR2, TLR4
14anti-fungal4410.2TLR4, TLR2, DEFB4A
15tarc4410.2CXCL11, CXCR3, CCL18
16infliximab44 49 1112.2CXCR3, CRP, TLR4
17ifn-alpha4410.2CXCR3, TLR3, TLR4
18resiquimod44 5911.2TLR4, TLR2, TLR9, TLR3
19loxoribine44 2811.2TLR9, TLR5, TLR2, TLR4
20glycolipid4410.2TLR4, TLR2, PLAU
21polyinosinic-polycytidylic acid4410.2TLR4, TLR2, TLR9, TLR3
22cefotaxime44 1111.1LACTB, TLR2
23ccl444 2811.1CXCL11, CXCR3, TLR2, CCL18
24hydroxychloroquine44 1111.1TLR9, CRP
25mcp 14410.1PLAU, CXCR3
26latex4410.0TLR4, TLR2, CRP, ITGA2
27poly(i-c)4410.0TLR4, TLR2, TLR5, TLR9, TLR3
28chloroquine44 2 49 28 1114.0TLR4, TLR9, PLAU
29gabexate mesilate449.9CRP, PLAU
30histamine44 28 2411.9TLR4, TLR2, DEFB4A, CXCR3, PLAU
31rantes449.9TLR4, TLR2, TLR5, DEFB4A, CXCR3, CXCL11
32aspirin44 49 28 2412.9TLR4, CRP, ITGA2, PLAU
33wortmannin449.9TLR4, TLR2, TLR3, CXCR3, PLAU
34sb 20358044 5910.9TLR4, TLR2, CRP, DEFB4A, PLAU
35lipoteichoic acid449.9TLR4, TLR2, TLR5, TLR9, TLR3, DEFB4A
36ly294002449.9TLR4, TLR3, CRP, CXCR3, PLAU
37peptidoglycan44 2810.9TLR4, TLR2, TLR5, TLR9, TLR3, DEFB4A
38fibrinogen449.8TLR4, TLR2, CRP, ITGA2, PLAU
39dexamethasone44 49 28 1112.8CCL18, TLR4, TLR2, TLR3, DEFB4A, CXCL11
40ccl344 2810.8CCL18, TLR4, TLR2, TLR9, CXCR3, CXCL11
41serine449.7TLR4, TLR2, TLR3, CXCR3, LACTB
42flagellin44 2810.7CXCR3, TLR4, TLR2, TLR5, TLR9, TLR3
43polysaccharide449.7PLAU, ITGA2, TLR2, TLR4
44nitric oxide44 11 2411.6TLR4, TLR2, TLR9, TLR3, ITGA2, CXCR3
45ceftriaxone44 1110.6LACTB, CRP
46phosphatidylinositol449.5TLR4, TLR2, TLR5, TLR3, ITGA2, CXCR3
47retinoic acid44 2410.5TLR4, TLR2, TLR3, ITGA2, DEFB4A, PLAU
48vegf449.4CCL18, TLR4, TLR2, CRP, ITGA2, CXCR3
49tyrosine448.8TLR4, TLR2, TLR5, TLR9, TLR3, MEFV
50calcium44 49 11 2411.7CCL18, TLR4, TLR2, CRP, ITGA2, DEFB4A

GO Terms for genes affiliated with Septic Arthritis

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Sources:
16Gene Ontology
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Cellular components related to Septic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome membraneGO:0360209.8TLR3, TLR9
2external side of plasma membraneGO:0098979.7CXCR3, ITGA2, TLR2, TLR4

Biological processes related to Septic Arthritis according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-alpha biosynthetic processGO:04535610.5TLR3, TLR9
2positive regulation of interleukin-18 productionGO:03274110.5TLR9, TLR2
3positive regulation of macrophage cytokine productionGO:06090710.4TLR2, TLR4
4regulation of cytokine secretionGO:05070710.4TLR4, TLR9
5cellular response to lipoteichoic acidGO:07122310.4TLR4, TLR2
6negative regulation of interleukin-17 productionGO:03270010.3TLR2, TLR4
7positive regulation of interferon-beta biosynthetic processGO:04535910.3TLR4, TLR9, TLR3
8positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.3TLR4, TLR2, TLR9
9cellular response to mechanical stimulusGO:07126010.3TLR3, TLR5, TLR4
10positive regulation of JNK cascadeGO:04633010.3TLR4, TLR9, TLR3
11positive regulation of interleukin-12 biosynthetic processGO:04508410.2TLR4, RELA
12positive regulation of toll-like receptor signaling pathwayGO:03412310.2TLR3, TLR9, TLR5, TLR2
13I-kappaB phosphorylationGO:00725210.2TLR4, TLR2, TLR9, TLR3
14positive regulation of chemokine productionGO:03272210.2TLR4, TLR2, TLR9, TLR3
15positive regulation of NF-kappaB import into nucleusGO:04234610.2TLR3, TLR9, TLR2, TLR4
16positive regulation of tumor necrosis factor biosynthetic processGO:04253510.1TLR2, TLR4
17positive regulation of interferon-beta productionGO:03272810.1TLR4, TLR2, TLR9, TLR3
18positive regulation of interleukin-12 productionGO:03273510.1TLR3, TLR9, TLR2, TLR4
19positive regulation of tumor necrosis factor productionGO:03276010.1TLR4, TLR2, TLR9, TLR3
20defense response to bacteriumGO:04274210.1TLR4, TLR9, TLR3, DEFB4A
21positive regulation of interleukin-6 productionGO:03275510.1TLR4, TLR2, TLR9, TLR3
22positive regulation of inflammatory responseGO:05072910.1TLR3, TLR9, TLR2, TLR4
23positive regulation of interleukin-10 productionGO:03273310.1TLR9, TLR4
24positive regulation of interleukin-8 productionGO:03275710.0TLR4, TLR2, TLR5, TLR9, TLR3
25toll-like receptor TLR6:TLR2 signaling pathwayGO:03812410.0TLR4, TLR2, RELA
26negative regulation of interleukin-12 productionGO:03269510.0MEFV, TLR2
27toll-like receptor TLR1:TLR2 signaling pathwayGO:03812310.0TLR4, TLR2, RELA
28TRIF-dependent toll-like receptor signaling pathwayGO:03566610.0RELA, TLR3, TLR4
29toll-like receptor 2 signaling pathwayGO:03413410.0TLR4, TLR2, RELA
30toll-like receptor 4 signaling pathwayGO:03414210.0TLR4, TLR2, TLR3, RELA
31positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.9RELA, TLR3, TLR9, TLR4
32MyD88-independent toll-like receptor signaling pathwayGO:0027569.9TLR4, TLR3, RELA
33chemotaxisGO:0069359.9PLAU, CXCL11, CXCR3, DEFB4A, CCL18
34toll-like receptor 3 signaling pathwayGO:0341389.9RELA, TLR3, TLR4
35immune responseGO:0069559.9CCL18, TLR4, TLR2, DEFB4A, CXCL11
36positive regulation of interferon-gamma biosynthetic processGO:0450789.8TLR3, TLR9
37MyD88-dependent toll-like receptor signaling pathwayGO:0027559.8TLR4, TLR2, TLR5, TLR9, RELA
38positive regulation of NF-kappaB transcription factor activityGO:0510929.8RELA, TLR3, TLR9, TLR2, TLR4
39toll-like receptor signaling pathwayGO:0022249.7TLR4, TLR2, TLR5, TLR9, TLR3, RELA
40signal transductionGO:0071659.1CCL18, TLR2, TLR3, HUNK, CXCL11, PLAU
41innate immune responseGO:0450879.1TLR4, TLR2, TLR5, TLR9, TLR3, MEFV
42inflammatory responseGO:0069548.9CXCL11, CCL18, TLR2, TLR5, TLR9, TLR3

Molecular functions related to Septic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.1TLR9, TLR5
2lipopolysaccharide receptor activityGO:00187510.0TLR2, TLR4
3transmembrane signaling receptor activityGO:0048889.7TLR3, TLR9, TLR2, TLR4
4receptor activityGO:0048729.4TLR4, TLR2, TLR3, TREM1

Products for genes affiliated with Septic Arthritis

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Sources for Septic Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet