MCID: SPT004
MIFTS: 55

Septic Arthritis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Septic Arthritis

Summaries for Septic Arthritis

MedlinePlus : 41 most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. infectious arthritis is an infection in the joint. the infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. symptoms of infectious arthritis include intense pain in the joint joint redness and swelling chills and fever inability to move the area with the infected joint one type of infectious arthritis is reactive arthritis. the reaction is to an infection somewhere else in your body. the joint is usually the knee, ankle, or toe. sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. in women, an infection in the vagina can cause the reaction. for both men and women, it can start with bacteria passed on during sex. another form of reactive arthritis starts with eating food or handling something that has bacteria on it. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to mycobacterium kansasii and influenza, and has symptoms including back pain, fever and muscle cramp. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hyaluronic acid and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and myeloid, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases : 50 infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. depending on the type of infection, one or more joints may be affected. certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. in reactive arthritis, joint inflammation develops weeks, months or even years after the infection. reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery. last updated: 3/31/2012

Wikipedia : 72 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

Related Diseases for Septic Arthritis

Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
id Related Disease Score Top Affiliating Genes
1 mycobacterium kansasii 30.7 CXCL8 TLR2
2 influenza 30.6 MMP2 MMP3
3 mycobacterium malmoense 30.4 CXCL8 TLR2
4 mycobacterium xenopi 30.1 CXCL8 TLR2
5 rheumatoid arthritis 29.7 CRP CXCL8 MMP3 TLR2 TLR4
6 arthritis 10.9
7 prothrombin thrombophilia 10.8 TLR2 TLR4
8 rickettsialpox 10.7 TLR2 TLR4
9 antigen-peptide-transporter 2 deficiency 10.7 TLR2 TLR4
10 fanconi syndrome 10.7 TLR2 TLR4
11 myelomeningocele 10.7 CRP TLR4
12 trichosporonosis 10.7 TLR2 TLR4
13 hereditary choroidal atrophy 10.7 TLR2 TLR4
14 aseptic meningitis 10.6 TLR2 TLR4
15 congenital insensitivity to pain with hyperhidrosis 10.6 CXCL8 TLR4
16 small cell lung cancer, adult 10.5 CRP CXCL8
17 alkhurma hemorrhagic fever 10.5 TLR2 TLR4
18 capillary leak syndrome 10.5 CRP CXCL8
19 halal setton wang syndrome 10.5 CXCL8 TLR2
20 hypertensive heart disease 10.5 CRP TLR2 TLR4
21 megaloblastic anemia 10.5 CRP TLR2 TLR4
22 compensatory emphysema 10.5 CRP TLR2 TLR4
23 gait apraxia 10.5 MMP2 MMP3
24 cardiocranial syndrome 10.5 CRP CXCL8
25 opportunistic bacterial infectious disease 10.5 CRP TLR2 TLR4
26 glycogen storage disease viii 10.5 CRP TLR4
27 charcot-marie-tooth disease, axonal, type 2cc 10.5 MMP2 MMP3
28 drug rash with eosinophilia and systemic symptoms 10.5 CXCL8 MMP2
29 subglottis neoplasm 10.5 CXCL8 TLR4
30 cicatricial lagophthalmos 10.4 CRP CXCL8
31 follicular mucinosis 10.4 CXCL8 TLR4
32 queensland tick typhus 10.4 CRP TLR2
33 bulbospinal polio 10.4 TLR3 TLR4
34 testicular infarct 10.4 CXCL8 TLR2 TLR4
35 tinea barbae 10.4 CXCL8 TLR2 TLR4
36 mucocutaneous leishmaniasis 10.3 CXCL8 TLR2 TLR4
37 atrophy of prostate 10.3 CRP CXCL8 TLR2
38 signet ring cell adenocarcinoma 10.3 CRP DEFB4A
39 osteomyelitis 10.3
40 myeloid sarcoma 10.3 CRP CXCL8 TLR4
41 premature ovarian failure 12 10.3 CXCL8 TLR2 TLR4
42 mixed mineral dust pneumoconiosis 10.3 CRP CXCL8 TLR2
43 esophagus melanoma 10.3 CRP CXCL8 TLR4
44 optic nerve hypoplasia 10.3 CXCL8 TLR2 TLR4
45 choroiditis 10.3 CRP CXCL8 TLR4
46 bullous retinoschisis 10.3 CXCL8 DEFB4A
47 neonatal period electroclinical syndrome 10.3 CRP CXCL8 TLR4
48 scabies 10.3 CRP CXCL8 TLR2
49 detrusor sphincter dyssynergia 10.3 CXCL8 TLR2 TLR4
50 pleomorphic rhabdomyosarcoma 10.3 CRP CXCR3

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis

Symptoms & Phenotypes for Septic Arthritis

UMLS symptoms related to Septic Arthritis:


back pain, fever, muscle cramp, pruritus, sciatica

MGI Mouse Phenotypes related to Septic Arthritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CRP CXCR3 MMP2 MMP7 RELA TLR2
2 hematopoietic system MP:0005397 9.97 CXCR3 ITGA2 MMP2 MMP3 MMP7 RELA
3 homeostasis/metabolism MP:0005376 9.96 MMP3 MMP7 RELA TLR2 TLR3 TLR4
4 immune system MP:0005387 9.81 CRP CXCR3 MMP2 MMP3 MMP7 RELA
5 neoplasm MP:0002006 9.43 CXCR3 MMP2 MMP7 TLR2 TLR3 TLR4
6 respiratory system MP:0005388 9.1 CXCR3 MMP2 RELA TLR2 TLR3 TLR4

Drugs & Therapeutics for Septic Arthritis

Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
3
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
4
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
5
Vancomycin Approved Phase 4 1404-90-6 441141 14969
6 Adjuvants, Immunologic Phase 4
7 Protective Agents Phase 4
8 Viscosupplements Phase 4
9 Anti-Infective Agents Phase 4,Early Phase 1
10 Anti-Infective Agents, Local Phase 4
11 Chlorhexidine gluconate Phase 4
12 Dermatologic Agents Phase 4
13 Disinfectants Phase 4
14 Anti-Bacterial Agents Phase 4,Early Phase 1
15
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
16 Anesthetics
17 Central Nervous System Depressants
18 Vaccines
19 Bone Density Conservation Agents
20 calcitonin
21 Calcitonin Gene-Related Peptide
22 Vasodilator Agents
23 Antibiotics, Antitubercular Early Phase 1
24 Antibodies Early Phase 1
25 Immunoglobulins Early Phase 1

Interventional clinical trials:

(show all 21)

id Name Status NCT ID Phase Drugs
1 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
2 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
3 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
4 Surgical Lavage vs Serial Needle Aspiration for Infected Joints Withdrawn NCT00313365 Phase 3
5 Arthrocentesis Study Unknown status NCT02530229
6 ARTEMIS Synovial Markers in Arthritis Childhood Unknown status NCT02505828
7 Utilization of Leukocyte Esterase in the Diagnosis of Pediatric Joint Infections Unknown status NCT02032732
8 Continuous Regional Anesthesia for Septic Limb Orthopedic Surgery Unknown status NCT01947660 Systemic analgesia + Continuous regional anesthesia;Systemic analgesia
9 Ultrasonography Assessment of Septic Arthritis on Native Joint Completed NCT02018952
10 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
11 Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Completed NCT01010165
12 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
13 The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries Completed NCT01333657
14 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
15 Procalcitonin Level and Kinetics in Children With Bacterial Infections Completed NCT00714402
16 Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques Recruiting NCT02565160
17 Operative and Non-operative Treatment of Traumatic Arthrotomies Recruiting NCT02841644
18 Pro-calcitonin for Early Detection of Septic Arthritis Active, not recruiting NCT02085733
19 Safety Study of Univers® Revers Shoulder Prosthesis Active, not recruiting NCT01778777
20 Ankle Joint Replacement Outcomes Study Active, not recruiting NCT00503438
21 Personalized Immunotherapeutic for Antibiotic-resistant Infection Enrolling by invitation NCT02508584 Early Phase 1

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

Genetic Tests for Septic Arthritis

Anatomical Context for Septic Arthritis

MalaCards organs/tissues related to Septic Arthritis:

39
Testes, Bone, Myeloid, Colon, Kidney, Skin, Neutrophil

Publications for Septic Arthritis

Articles related to Septic Arthritis:

(show top 50) (show all 724)
id Title Authors Year
1
Peripheral Bacterial Septic Arthritis: Review of Diagnosis and Management. ( 28926460 )
2017
2
Cutibacteriumacnes Septic Arthritis of the Nonoperated Knee: A Case Report. ( 28825032 )
2017
3
Clinical significance of delta neutrophil index in the differential diagnosis between septic arthritis and acute gout attack within 24 hours after hospitalization. ( 28746185 )
2017
4
Cervical facet joint septic arthritis: a real pain in the neck. ( 28775081 )
2017
5
Septic arthritis significantly increased the long-term mortality in geriatric patients. ( 28793879 )
2017
6
Pathogen or contaminant? Distinguishing true infection from synovial fluid culture contamination in patients with suspected septic arthritis. ( 28766274 )
2017
7
A rare complication of tonsillitis: septic arthritis of the temporomandibular joint. ( 28461120 )
2017
8
Mycobacterium avium Complex Septic Arthritis Presenting as Osteonecrosis of the Femoral Head in a Patient With Systemic Lupus Erythematosus. ( 28056158 )
2017
9
Arthroscopic Versus Open Treatment for Acute Septic Arthritis of the Knee in Children. ( 28945678 )
2017
10
Impact of cell wall peptidoglycan O-acetylation on the pathogenesis of Staphylococcus aureus in septic arthritis. ( 28802679 )
2017
11
Septic arthritis of the temporomandibular joint after acute otitis media in a child. ( 28944379 )
2017
12
Concomitant crystal-induced and septic arthritis. ( 28725566 )
2017
13
Effect of arthroscopic lavage and repeated intra-articular administrations of antibiotic in adult horses and foals with septic arthritis. ( 28771839 )
2017
14
Clinical Characteristics and Outcomes in Polyarticular Septic Arthritis. ( 28917998 )
2017
15
Acute osteomyelitis and septic arthritis in children : AA referral hospital-based study in Iran. ( 28744778 )
2017
16
Atypical osteomyelitis and concurrent septic arthritis due to Salmonella in immunocompetent children. ( 28951650 )
2017
17
Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study. ( 28862129 )
2017
18
Overwhelming Streptococcus pyogenes sepsis in an elderly patient with septic arthritis. ( 28882472 )
2017
19
Outbreak of Septic Arthritis Associated with Intra-Articular Injections at an Outpatient Practice - New Jersey, 2017. ( 28749922 )
2017
20
Ankylosis of the knee after septic arthritis following anterior cruciate ligament reconstruction in a 13-year-old male. ( 28342819 )
2017
21
Predicting Periarticular Infection in Children With Septic Arthritis of the Hip: Regionally Derived Criteria May Not Apply to All Populations. ( 28060181 )
2017
22
Imaging of Posttraumatic Arthritis, Avascular Necrosis, Septic Arthritis, Complex Regional Pain Syndrome, and Cancer Mimicking Arthritis. ( 28774452 )
2017
23
Lemierre's syndrome; a rare cause of septic arthritis. ( 28500126 )
2017
24
Haemophilus influenzae serotype f endocarditis and septic arthritis. ( 28725560 )
2017
25
The burden of septic arthritis on the U.S. inpatient care: A national study. ( 28809954 )
2017
26
Surgical Management of Multijoint Septic Arthritis due to Rat-Bite Fever in a Pediatric Patient: A Case Study. ( 28255484 )
2017
27
Predictive Factors for Differentiating Between Septic Arthritis and Lyme Disease of the Knee in Children. ( 27147684 )
2016
28
When in Doubt, Examine the Patient: Commentary on an article by Keith D. Baldwin, MD, MSPT, MPH, et al.: "Predictive Factors for Differentiating Between Septic Arthritis and Lyme Disease of the Knee in Children". ( 27147695 )
2016
29
Life-threatening MRSA sepsis with bilateral pneumonia, osteomyelitis, and septic arthritis of the knee in a previously healthy 13-year-old boy: a case report. ( 27867536 )
2016
30
Septic arthritis due to Legionella cincinnatiensis: case report and review of the literature. ( 27848164 )
2016
31
The Contemporary Microbiology and Rates of Concomitant Osteomyelitis in Acute Septic Arthritis. ( 27870814 )
2016
32
Delayed treatment of septic arthritis in the neonate: A review of 52 cases. ( 28002339 )
2016
33
RAGE Deficiency Impairs Bacterial Clearance in Murine Staphylococcal Sepsis, but Has No Significant Impact on Staphylococcal Septic Arthritis. ( 27907047 )
2016
34
Septic arthritis caused by Mycobacterium marinum infection. ( 27862193 )
2016
35
Adult Native Septic Arthritis in an Inner City Hospital: Effects on Length of Stay. ( 27111073 )
2016
36
The use of continuous negative pressure after open debridement for septic arthritis of the shoulder. ( 27143738 )
2016
37
Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination. ( 27901071 )
2016
38
Surgical Management of Septic Arthritis. ( 27618571 )
2016
39
Key role of magnetic resonance imaging in the diagnosis of infections around the hip and pelvic girdle mimicking septic arthritis of the hip in children. ( 27007545 )
2016
40
First diagnosis of septic arthritis in a dinosaur. ( 27853597 )
2016
41
Prognostic Factors Affecting the Clinical Outcome of Septic Arthritis of the Shoulder. ( 27595951 )
2016
42
Mycotic Septic Arthritis of the Ankle Joint. ( 28005106 )
2016
43
Primary Bacterial Gluteal Pyomyositis: A Rare Disease in Temperate Climates Presenting as Suspected Septic Arthritis of the Hip. ( 27369856 )
2016
44
Septic arthritis in children in resource limited and non-resource limited countries: an update on diagnosis and treatment. ( 27629150 )
2016
45
Arthrodesis for septic arthritis of the ankle: risk factors and complications. ( 27447881 )
2016
46
Septic arthritis and arthropathy of the rotator cuff: remember this association. ( 27517024 )
2016
47
Draft Whole-Genome Sequence of a Catalase-Negative Staphylococcus aureus subsp. aureus (Sequence Type 25) Strain Isolated from a Patient with Endocarditis and Septic Arthritis. ( 28007866 )
2016
48
Pediatric hypervirulent Klebsiella pneumoniae septic arthritis. ( 27005513 )
2016
49
Septic arthritis caused by Peptostreptococcus asaccharolyticus. ( 27155565 )
2016
50
Septic arthritis of the wrist caused by Mycobacterium intracellulare: a case report. ( 27990457 )
2016

Variations for Septic Arthritis

Expression for Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for Septic Arthritis

Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 47)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CRP CXCL8 DEFB4A MMP2 MMP3 RELA
2
Show member pathways
13.28 CXCL8 CXCR3 ITGA2 MMP2 MMP3 MMP7
3
Show member pathways
13.28 CXCL8 CXCR3 ITGA2 TLR2 TLR3 TLR4
4
Show member pathways
12.85 CXCL8 RELA TLR2 TLR3 TLR4
5
Show member pathways
12.7 CXCL8 RELA TLR2 TLR3 TLR4
6
Show member pathways
12.65 CXCL8 RELA TLR2 TLR3 TLR4
7
Show member pathways
12.64 ITGA2 MMP2 MMP3 MMP7
8
Show member pathways
12.6 RELA TLR2 TLR3 TLR4
9 12.56 CXCL8 ITGA2 MMP2 RELA
10 12.54 ITGA2 RELA TLR2 TLR3 TLR4
11 12.16 ITGA2 MMP2 TLR2 TLR4
12
Show member pathways
12.15 RELA TLR2 TLR4
13 12.13 CXCL8 MMP3 RELA
14 12.12 RELA TLR2 TLR4
15
Show member pathways
12.11 CXCL8 RELA TLR3 TLR4
16
Show member pathways
12.1 CXCL8 DEFB4A MMP3 RELA TLR2
17 12.04 ITGA2 TLR2 TLR4
18 11.98 TLR2 TLR3 TLR4
19 11.96 CXCL8 RELA TLR3
20 11.89 CXCL8 MMP2 MMP3
21
Show member pathways
11.87 RELA TLR2 TLR3 TLR4
22
Show member pathways
11.86 TLR2 TLR3 TLR4
23 11.82 CXCL8 MMP2 RELA
24
Show member pathways
11.81 MMP2 MMP3 MMP7
25
Show member pathways
11.8 TLR2 TLR3 TLR4
26 11.79 CXCL8 RELA TLR4
27 11.77 CXCL8 RELA TLR4
28
Show member pathways
11.77 CXCL8 RELA TLR4
29 11.74 CXCL8 RELA TLR2 TLR4
30 11.71 MMP2 MMP3 MMP7
31 11.7 CXCL8 RELA TLR4
32 11.69 CXCL8 MMP3 TLR2 TLR4
33 11.64 CXCL8 RELA TLR4
34 11.63 ITGA2 TLR2 TLR3 TLR4
35 11.57 MMP2 MMP7 RELA
36
Show member pathways
11.57 CXCL8 DEFB4A RELA TLR2 TLR4
37 11.56 CXCL8 MMP2 RELA
38
Show member pathways
11.42 CXCL8 MMP2 MMP3 RELA
39 11.4 CXCL8 TLR2 TLR4
40 11.34 CXCL8 MMP2 MMP3 MMP7
41 11.24 MMP2 MMP7 TLR2 TLR3 TLR4
42 11.2 CXCL8 RELA TLR2 TLR4
43 11.19 CXCL8 ITGA2 MMP2
44 11.07 CXCL8 RELA
45 11.07 TLR3 TLR4
46 11 RELA TLR2
47 10.95 CRP CXCL8

GO Terms for Septic Arthritis

Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 CRP CXCL8 DEFB4A MMP2 MMP3 MMP7
2 intrinsic component of plasma membrane GO:0031226 9.16 TLR2 TLR4
3 cell surface GO:0009986 9.1 CXCR3 ITGA2 MMP7 TLR2 TLR3 TLR4

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 38)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 CXCL8 DEFB4A TLR2 TLR4
2 positive regulation of gene expression GO:0010628 9.94 CRP TLR2 TLR3 TLR4
3 response to hypoxia GO:0001666 9.85 ITGA2 MMP2 TLR2
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.84 RELA TLR3 TLR4
5 chemotaxis GO:0006935 9.83 CXCL8 CXCR3 DEFB4A
6 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 RELA TLR4
7 defense response GO:0006952 9.83 CXCL8 DEFB4A RELA TLR3
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 RELA TLR2 TLR3 TLR4
9 defense response to Gram-positive bacterium GO:0050830 9.79 CRP DEFB4A TLR2
10 extracellular matrix disassembly GO:0022617 9.78 MMP2 MMP3 MMP7
11 collagen catabolic process GO:0030574 9.76 MMP2 MMP3 MMP7
12 positive regulation of tumor necrosis factor production GO:0032760 9.74 TLR2 TLR3 TLR4
13 positive regulation of interleukin-6 production GO:0032755 9.72 TLR2 TLR3 TLR4
14 toll-like receptor signaling pathway GO:0002224 9.71 TLR2 TLR3 TLR4
15 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.68 TLR3 TLR4
16 positive regulation of interleukin-10 production GO:0032733 9.66 TLR2 TLR4
17 negative regulation of osteoclast differentiation GO:0045671 9.65 TLR3 TLR4
18 necroptotic process GO:0070266 9.65 TLR3 TLR4
19 positive regulation of interleukin-8 production GO:0032757 9.65 TLR2 TLR3 TLR4
20 microglial cell activation GO:0001774 9.64 TLR2 TLR3
21 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.63 TLR2 TLR4
22 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 TLR2
23 positive regulation of interferon-beta production GO:0032728 9.63 TLR2 TLR3 TLR4
24 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.62 TLR3 TLR4
25 regulation of cytokine secretion GO:0050707 9.62 TLR2 TLR4
26 cellular response to mechanical stimulus GO:0071260 9.62 ITGA2 MMP7 TLR3 TLR4
27 positive regulation of interleukin-12 production GO:0032735 9.61 TLR2 TLR3 TLR4
28 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.6 TLR3 TLR4
29 positive regulation of interferon-beta biosynthetic process GO:0045359 9.59 TLR3 TLR4
30 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.58 RELA TLR4
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.58 TLR2 TLR3 TLR4
32 positive regulation of toll-like receptor signaling pathway GO:0034123 9.56 TLR2 TLR3
33 positive regulation of inflammatory response GO:0050729 9.56 ITGA2 TLR2 TLR3 TLR4
34 positive regulation of chemokine production GO:0032722 9.54 TLR2 TLR3 TLR4
35 regulation of dendritic cell cytokine production GO:0002730 9.49 TLR3 TLR4
36 I-kappaB phosphorylation GO:0007252 9.33 TLR2 TLR3 TLR4
37 inflammatory response GO:0006954 9.17 CRP CXCL8 CXCR3 RELA TLR2 TLR3
38 cellular response to lipoteichoic acid GO:0071223 8.96 TLR2 TLR4

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.5 ITGA2 RELA TLR2
2 metallopeptidase activity GO:0008237 9.33 MMP2 MMP3 MMP7
3 lipopolysaccharide binding GO:0001530 9.26 TLR2 TLR4
4 metalloendopeptidase activity GO:0004222 9.13 MMP2 MMP3 MMP7
5 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Septic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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