MCID: SPT004
MIFTS: 60

Septic Arthritis malady

Summaries for Septic Arthritis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. infectious arthritis is an infection in the joint. the infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. symptoms of infectious arthritis include intense pain in the joint joint redness and swelling chills and fever inability to move the area with the infected joint one type of infectious arthritis is reactive arthritis. the reaction is to an infection somewhere else in your body. the joint is usually the knee, ankle, or toe. sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. in women, an infection in the vagina can cause the reaction. for both men and women, it can start with bacteria passed on during sex. another form of reactive arthritis starts with eating food or handling something that has bacteria on it. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery.

MalaCards: Septic Arthritis, also known as infectious arthritis, is related to arthritis and osteomyelitis. An important gene associated with Septic Arthritis is CXCL11 (chemokine (C-X-C motif) ligand 11), and among its related pathways are Trafficking and processing of endosomal TLR and Osteopontin Signaling. The compounds cycloheximide and asialo gm1 have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and bone, and related mouse phenotypes are respiratory system and tumorigenesis.

Disease Ontology:8 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases:42 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. depending on the type of infection, one or more joints may be affected. certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. in reactive arthritis, joint inflammation develops weeks, months or even years after the infection. reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery. last updated: 3/31/2012

Wikipedia:63 Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis.... more...

Aliases & Classifications for Septic Arthritis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 33MedlinePlus, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

septic arthritis 8 42 10
infectious arthritis 8 42 33
acute suppurative arthritis due to bacteria 60
arthritis, infectious 60
arthritis septic 44


Related Diseases for Septic Arthritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.0LACTB, CXCR3, MEFV, CRP, TLR3, TLR2
2osteomyelitis31.1CRP, ITGA2, LACTB
3rheumatoid arthritis30.8CCL18, TLR4, TLR2, TLR9, TLR3, CRP
4influenza30.5CCL18, TLR5, TLR9, TLR3, CXCR3, LACTB
5pneumonia30.5CCL18, TLR4, TLR2, TLR5, TLR3, CRP
6lupus erythematosus30.4TLR9
7melioidosis30.4TLR4, TLR2, TLR5
8systemic lupus erythematosus30.4TLR4, TLR2, TLR5, TLR9, CRP, CXCR3
9crohn's disease30.3CRP
10myeloma30.3ITGA2
11leukemia30.3LACTB, CXCR3, TLR2, TLR4
12familial mediterranean fever30.2MEFV, CRP
13otitis media30.2LACTB, TLR2
14mediastinitis30.2CRP
15osteoarthritis30.2TLR2, TLR3, CRP, DEFB4A, CXCR3, PLAU
16glomerulonephritis30.0TLR9
17hepatitis30.0TLR2, TLR3
18brucellosis30.0MEFV, ITGA2
19pulmonary fibrosis30.0PLAU, CXCR3, CCL18
20appendicitis30.0CRP, LACTB
21peritonitis30.0LACTB, MEFV, CRP, TLR2
22hepatitis c30.0TLR4, TLR2, TLR3, CXCR3, CXCL11
23pyelonephritis30.0TLR4, CRP, LACTB
24colon cancer30.0TLR2, TLR5, TLR9, ITGA2, PLAU
25tuberculosis30.0TLR4, TLR2, TLR9, CRP, DEFB4A, TREM1
26pancreatitis29.9CRP
27lyme disease29.9LACTB, TLR2
28meningitis29.9TLR2, CRP, LACTB
29bacterial meningitis29.9LACTB, CRP, TLR2
30pyomyositis10.5
31pseudogout10.5
32reactive arthritis10.4
33transient arthritis10.4
34ankylosis10.4
35synovitis10.4
36gout10.3
37epidural abscess10.3
38osteonecrosis10.2
39bursitis10.2
40multiple myeloma10.2
41neuropathy10.2
42pericarditis10.2
43rheumatic fever10.2
44felty's syndrome10.2
45chickenpox10.2
46blastomycosis10.2
47acute leukemia10.2
48brachial plexus neuropathy10.2
49endocarditis10.2
50otitis externa10.2

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to septic arthritis

Clinical Features for Septic Arthritis

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Drugs & Therapeutics for Septic Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Septic Arthritis

Drug clinical trials:

Search ClinicalTrials for Septic Arthritis

Search NIH Clinical Center for Septic Arthritis

Search CenterWatch for Septic Arthritis

Genetic Tests for Septic Arthritis

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Anatomical Context for Septic Arthritis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Septic Arthritis:

32
Testes, Bone, Skin, Colon, Liver, Cervix, Myeloid

FMA organs/tissues related to Septic Arthritis:

14
Joint

Animal Models for Septic Arthritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Septic Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.8RELA, CXCR3, PLAU
2MP:00020069.6TLR3, TREM1, HUNK, CXCR3
3MP:00053709.2TLR2, TLR5, MEFV, RELA, PLAU, TLR4
4MP:00053978.6TLR4, TLR2, TLR5, TLR9, MEFV, ITGA2
5MP:00053858.5TLR4, TLR2, TLR5, TLR3, CRP, RELA
6MP:00053878.4PLAU, TLR4, TLR2, TLR5, TLR9, TLR3
7MP:00053848.2TLR4, TLR2, TLR5, TLR9, MEFV, ITGA2
8MP:00053768.1TLR3, TLR9, TLR5, TLR2, TLR4, CRP

Publications for Septic Arthritis

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50PubMed
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Articles related to Septic Arthritis:

(show top 50)    (show all 584)
idTitleAuthorsYear
1
Three Cases of Postoperative Septic Arthritis Caused by Mycobacterium conceptionense in Shoulder Joints of Immunocompetent Patients. (24391195)
2014
2
Management of septic arthritis following anterior cruciate ligament reconstruction: a review of current practices and recommendations. (24187034)
2013
3
Rheumatic disease presenting as septic arthritis: a report of 10 cases. (22447330)
2013
4
In vivo macrophage imaging using MR targeted contrast agent for longitudinal evaluation of septic arthritis. (24193324)
2013
5
Surgical treatment for septic arthritis of the knee joint in elderly patients: a 10-year retrospective clinical study. (23590782)
2013
6
Septic arthritis associated to gout and pseudout: The importance of arthrocenthesis. (23540795)
2013
7
Sternoclavicular joint septic arthritis and osteomyelitis caused by Aggregatibacter aphrophilus. (22223671)
2012
8
Management of a child with suspected acute septic arthritis. (21953417)
2012
9
Hematogenous septic arthritis of the hip in adult patients. (22306386)
2012
10
Genome sequence of Kingella kingae septic arthritis isolate PYKK081. (22582375)
2012
11
Septic arthritis of the hip after nonoperative treatment of a pelvic fracture associated with bladder rupture. (22337485)
2012
12
Percutaneous aspiration irrigation drainage technique in the management of septic arthritis in children. (21307737)
2011
13
Septic arthritis of the knee: presentation of a novel irrigation-suction system tested in a cadaver study. (21819619)
2011
14
Haemophilus parainfluenzae septic arthritis: report of a case and review of the literature. (21507531)
2011
15
Anal fistula associated with septic arthritis. (20871094)
2011
16
Monoarticular pseudogout of the hip presenting as septic arthritis: a case report. (21765235)
2011
17
Intra-articular therapy to treat septic arthritis in a dog. (21673329)
2011
18
Minimally invasive washout of the shoulder for septic arthritis in children: a new technique. (21929923)
2011
19
Septic arthritis: monitoring with USPIO-enhanced macrophage MR imaging. (21339348)
2011
20
Psoas abscess with associated septic arthritis of the hip in infants. (21129563)
2010
21
Septic arthritis of the temporomandibular joint: a retrospective review of 40 cases. (19954877)
2010
22
Manubriosternal subluxation/dislocation can lead to manubriosternal septic arthritis in patients with kyphoscoliosis. (20353634)
2010
23
Therapy: Optimum therapy in septic arthritis: to cut or not to cut? (20046201)
2010
24
Tranexamic acid, an inhibitor of plasminogen activation, aggravates staphylococcal septic arthritis and sepsis. (20100112)
2010
25
Arthroscopic treatment of septic arthritis of acromioclavicular joint. (20808591)
2010
26
A case of severe staphylococcal septicaemia: septic arthritis and a mediastinal abscess following leflunamide therapy for rheumatoid arthritis. (22766573)
2010
27
Septic arthritis of sternoclavicular joint: a case report of a rare finding in injecting drug users. (20433232)
2010
28
Optimal management of sternoclavicular septic arthritis. (19404199)
2009
29
Septic arthritis of the knee joint secondary to Prevotella bivia. (19271076)
2009
30
Septic arthritis of the hip associated with supra-acetabular external fixation of unstable pelvic ring: a case report. (19742100)
2009
31
Septic arthritis as the initial manifestation of fatal Vibrio vulnificus septicemia in a patient with thalassemia and iron overload. (19591224)
2009
32
Moraxella lacunata septic arthritis in a patient with lupus nephritis. (19794049)
2009
33
Septic arthritis due to Roseomonas gilardii in an immunocompetent adolescent. (19574413)
2009
34
Comparison of arthroscopic and open treatment of septic arthritis of the wrist. (19884463)
2009
35
Surgical management of septic arthritis of the knee with a coexistent popliteal cyst. (19501300)
2009
36
An immunocompetent patient presenting with severe septic arthritis due to Ralstonia pickettii identified by molecular-based assays: a case report. (19830053)
2009
37
Septic arthritis in haemodialysis patients: a seven-year multi-centre review. (18453661)
2008
38
Rheumatoid arthritis is the major risk factor for septic arthritis in rheumatological settings. (18706527)
2008
39
The importance of irrigation suction drainage in the treatment of septic arthritis after anterior cruciate ligament reconstruction. (19038718)
2008
40
A case of septic arthritis of the sternoclavicular joint after coronary angiography. (19078918)
2008
41
Septic arthritis of hip after radiotherapy for carcinoma of cervix. (18465041)
2008
42
Septic arthritis after arthroscopic anterior cruciate ligament reconstruction: a retrospective analysis of incidence, management and outcome. (17369557)
2007
43
Concurrent septic arthritis and urinary tract infection in a patient with nephrocalcinosis and vesicoureteral reflux. (17172078)
2006
44
Spontaneous Clostridium septicum septic arthritis of the shoulder and gas gangrene. a case report. (15805220)
2005
45
Assessment of the test characteristics of C-reactive protein for septic arthritis in children. (12724603)
2003
46
Isolated septic arthritis: meningococcal infection. (12724437)
2003
47
Mycobacterium kansasii septic arthritis: French retrospective study of 5 years and review. (10585795)
1999
48
Atrial and venous thrombosis secondary to septic arthritis of the sacroiliac joint in a child with hereditary protein C deficiency. (10088680)
1999
49
Ankylosis of the distal interphalangeal joint in a horse after septic arthritis and septic navicular bursitis. (1577652)
1992
50
High synovial fluid white blood cell counts in pseudogout; Possible confusion with septic arthritis. (167668)
1975

Genetic Variations for Septic Arthritis

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Expression for genes affiliated with Septic Arthritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for genes affiliated with Septic Arthritis

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Septic Arthritis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TLR9, TLR3
29.9RELA, PLAU
39.9TLR9, TLR2, TLR4
4
Mucin expression in CF via IL-6, IL-17 signaling pathways
Hide members
9.8TLR2, TLR5, RELA
5
Hide members
9.8RELA, TLR3, TLR4
6
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.8RELA, TLR3, TLR4
79.8TLR4, TLR5, RELA
89.8RELA, TLR2, TLR4
99.7TLR4, RELA, PLAU
109.6TLR4, TLR2, ITGA2, PLAU
11
Hide members
9.6TLR4, TLR2, TLR5, RELA
129.6TLR4, TLR2, TLR5, RELA
13
Hide members
9.6CCL18, RELA, CXCR3, CXCL11
149.6RELA, TLR9, TLR2, TLR4
159.6TLR4, TLR2, TLR5, TLR9, TLR3
16
Hide members
9.6TLR4, TLR2, TLR5, TLR9, TLR3
17
Hide members
9.6TLR4, TLR2, TLR5, TLR9, TLR3
18
Hide members
9.6TLR4, TLR2, TLR5, TLR9, TLR3
19
Hide members
9.5CCL18, ITGA2, CXCR3, CXCL11, PLAU
20
Immune response Bacterial infections in normal airways
9.4TLR4, TLR2, TLR5, DEFB4A, RELA
21
Hide members
9.4TLR4, TLR2, TLR9, TLR3, RELA
229.4TLR4, TLR2, TLR9, TLR3, RELA
239.4TLR4, TLR2, TLR5, TLR9, TLR3, ITGA2
24
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, TREM1
259.3CXCL11, RELA, TLR9, TLR5, TLR2, TLR4
269.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
27
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
28
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
29
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
30
Hide members
9.3TLR4, TLR2, TLR5, TLR9, TLR3, RELA
31
Hide members
9.1TLR4, TLR2, TLR5, TLR9, TLR3, RELA
32
Hide members
8.8CCL18, TLR4, TLR2, TLR5, TLR9, TLR3
33
Hide members
8.6TLR4, TLR2, TLR5, TLR9, TLR3, MEFV

Compounds for genes affiliated with Septic Arthritis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Septic Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5TLR2
2asialo gm14410.5TLR5, TLR2
3arabinogalactan4410.4TLR2, TLR4
4diaminopimelic acid4410.4TLR4, TLR2
5poly(i:c)5910.3TLR3, TLR2, TLR4
6pam2csk45910.3TLR4, TLR3, TLR2
7pam3csk45910.3TLR2, TLR4, TLR3
8hbd24410.3TLR2, DEFB4A, TLR4
9glucuronoxylomannan4410.3TLR2, TLR4
10imiquimod44 28 59 1113.3TLR2, TLR4, TLR3
11muramyl dipeptide44 2811.3TLR4, TLR2
12endotoxin4410.2TLR3, DEFB4A, MEFV, CXCR3
13il 104410.2TLR4, TLR2, CXCR3
14anti-fungal4410.2DEFB4A, TLR4, TLR2
15tarc4410.2CXCL11, CXCR3, CCL18
16infliximab44 49 1112.2CRP, TLR4, CXCR3
17ifn-alpha4410.2CXCR3, TLR3, TLR4
18resiquimod44 5911.2TLR3, TLR9, TLR4, TLR2
19loxoribine44 2811.2TLR2, TLR5, TLR4, TLR9
20glycolipid4410.2PLAU, TLR2, TLR4
21polyinosinic-polycytidylic acid4410.2TLR9, TLR2, TLR4, TLR3
22cefotaxime44 1111.1LACTB, TLR2
23ccl444 2811.1TLR2, CXCR3, CXCL11, CCL18
24latex4410.0TLR4, TLR2, ITGA2, CRP
25gabexate mesilate4410.0CRP, PLAU
26poly(i-c)4410.0TLR2, TLR5, TLR3, TLR4, TLR9
27hydroxychloroquine44 1111.0CRP, TLR9
28chloroquine44 2 49 28 1114.0TLR4, TLR9, PLAU
29ceftriaxone44 1110.9LACTB, CRP
30histamine44 28 2411.9PLAU, TLR2, CXCR3, TLR4, DEFB4A
31rantes449.9CXCR3, TLR5, TLR2, TLR4, DEFB4A, CXCL11
32aspirin44 49 28 2412.9PLAU, TLR4, CRP, ITGA2
33wortmannin449.9CXCR3, TLR3, TLR2, PLAU, TLR4
34sb 20358044 5910.9PLAU, TLR4, CRP, TLR2, DEFB4A
35lipoteichoic acid449.9TLR2, TLR4, TLR3, TLR9, DEFB4A, TLR5
36ly294002449.9PLAU, CXCR3, TLR4, CRP, TLR3
37peptidoglycan44 2810.9TLR3, TLR5, TLR2, TLR4, TLR9, DEFB4A
38fibrinogen449.8TLR2, PLAU, CRP, ITGA2, TLR4
39dexamethasone44 49 28 1112.8CCL18, CXCL11, DEFB4A, TLR2, TLR4, TLR3
40ccl344 2810.8CCL18, TLR4, TLR2, TLR9, CXCR3, CXCL11
41mcp 1449.8PLAU, CXCR3
42serine449.7TLR2, CXCR3, TLR3, LACTB, TLR4
43flagellin44 2810.7DEFB4A, TLR4, TLR2, TLR5, TLR9, TLR3
44polysaccharide449.7TLR4, PLAU, ITGA2, TLR2
45nitric oxide44 11 2411.6CXCR3, TLR4, TLR2, TLR9, TLR3, ITGA2
46phosphatidylinositol449.5TLR3, PLAU, TLR5, TLR4, TLR2, ITGA2
47retinoic acid44 2410.5PLAU, TLR2, TLR3, ITGA2, DEFB4A, TLR4
48vegf449.4CRP, CXCR3, TLR2, TLR4, PLAU, CCL18
49tyrosine448.8TLR3, TLR2, TLR5, TLR9, PLAU, MEFV
50calcium44 49 11 2411.7ITGA2, CCL18, TREM1, RELA, CXCR3, DEFB4A

GO Terms for genes affiliated with Septic Arthritis

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16Gene Ontology
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Cellular components related to Septic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome membraneGO:0360209.8TLR3, TLR9
2external side of plasma membraneGO:0098979.7CXCR3, ITGA2, TLR2, TLR4

Biological processes related to Septic Arthritis according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-alpha biosynthetic processGO:04535610.5TLR3, TLR9
2positive regulation of interleukin-18 productionGO:03274110.5TLR9, TLR2
3positive regulation of macrophage cytokine productionGO:06090710.4TLR2, TLR4
4regulation of cytokine secretionGO:05070710.4TLR4, TLR9
5cellular response to lipoteichoic acidGO:07122310.4TLR4, TLR2
6negative regulation of interleukin-17 productionGO:03270010.3TLR2, TLR4
7positive regulation of interferon-beta biosynthetic processGO:04535910.3TLR4, TLR9, TLR3
8positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.3TLR4, TLR2, TLR9
9cellular response to mechanical stimulusGO:07126010.3TLR3, TLR5, TLR4
10positive regulation of JNK cascadeGO:04633010.3TLR4, TLR9, TLR3
11positive regulation of interleukin-12 biosynthetic processGO:04508410.2TLR4, RELA
12positive regulation of toll-like receptor signaling pathwayGO:03412310.2TLR3, TLR9, TLR5, TLR2
13I-kappaB phosphorylationGO:00725210.2TLR4, TLR2, TLR9, TLR3
14positive regulation of chemokine productionGO:03272210.2TLR4, TLR2, TLR9, TLR3
15positive regulation of NF-kappaB import into nucleusGO:04234610.2TLR3, TLR9, TLR2, TLR4
16positive regulation of tumor necrosis factor biosynthetic processGO:04253510.1TLR2, TLR4
17positive regulation of interferon-beta productionGO:03272810.1TLR4, TLR2, TLR9, TLR3
18positive regulation of interleukin-12 productionGO:03273510.1TLR3, TLR9, TLR2, TLR4
19positive regulation of tumor necrosis factor productionGO:03276010.1TLR4, TLR2, TLR9, TLR3
20defense response to bacteriumGO:04274210.1TLR4, TLR9, TLR3, DEFB4A
21positive regulation of interleukin-6 productionGO:03275510.1TLR4, TLR2, TLR9, TLR3
22positive regulation of inflammatory responseGO:05072910.1TLR3, TLR9, TLR2, TLR4
23positive regulation of interleukin-10 productionGO:03273310.1TLR9, TLR4
24positive regulation of interleukin-8 productionGO:03275710.0TLR4, TLR2, TLR5, TLR9, TLR3
25toll-like receptor TLR6:TLR2 signaling pathwayGO:03812410.0TLR4, TLR2, RELA
26negative regulation of interleukin-12 productionGO:03269510.0MEFV, TLR2
27toll-like receptor TLR1:TLR2 signaling pathwayGO:03812310.0TLR4, TLR2, RELA
28TRIF-dependent toll-like receptor signaling pathwayGO:03566610.0RELA, TLR3, TLR4
29toll-like receptor 2 signaling pathwayGO:03413410.0TLR4, TLR2, RELA
30toll-like receptor 4 signaling pathwayGO:03414210.0TLR4, TLR2, TLR3, RELA
31positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.9RELA, TLR3, TLR9, TLR4
32MyD88-independent toll-like receptor signaling pathwayGO:0027569.9TLR4, TLR3, RELA
33chemotaxisGO:0069359.9PLAU, CXCL11, CXCR3, DEFB4A, CCL18
34toll-like receptor 3 signaling pathwayGO:0341389.9RELA, TLR3, TLR4
35immune responseGO:0069559.9CCL18, TLR4, TLR2, DEFB4A, CXCL11
36positive regulation of interferon-gamma biosynthetic processGO:0450789.8TLR3, TLR9
37MyD88-dependent toll-like receptor signaling pathwayGO:0027559.8TLR4, TLR2, TLR5, TLR9, RELA
38positive regulation of NF-kappaB transcription factor activityGO:0510929.8RELA, TLR3, TLR9, TLR2, TLR4
39toll-like receptor signaling pathwayGO:0022249.7TLR4, TLR2, TLR5, TLR9, TLR3, RELA
40signal transductionGO:0071659.1CCL18, TLR2, TLR3, HUNK, CXCL11, PLAU
41innate immune responseGO:0450879.1TLR4, TLR2, TLR5, TLR9, TLR3, MEFV
42inflammatory responseGO:0069548.9CXCL11, CCL18, TLR2, TLR5, TLR9, TLR3

Molecular functions related to Septic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.1TLR9, TLR5
2lipopolysaccharide receptor activityGO:00187510.0TLR2, TLR4
3transmembrane signaling receptor activityGO:0048889.7TLR3, TLR9, TLR2, TLR4
4receptor activityGO:0048729.4TLR4, TLR2, TLR3, TREM1

Products for genes affiliated with Septic Arthritis

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Sources for Septic Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet