MCID: SPT004
MIFTS: 60

Septic Arthritis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Septic Arthritis

Summaries for Septic Arthritis

MedlinePlus : 40 Most kinds of arthritis cause pain and swelling in your joints. Joints are places where two bones meet, such as your elbow or knee. Infectious arthritis is an infection in the joint. The infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. Symptoms of infectious arthritis include Intense pain in the joint Joint redness and swelling Chills and fever Inability to move the area with the infected joint One type of infectious arthritis is reactive arthritis. The reaction is to an infection somewhere else in your body. The joint is usually the knee, ankle, or toe. Sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. In women, an infection in the vagina can cause the reaction. For both men and women, it can start with bacteria passed on during sex. Another form of reactive arthritis starts with eating food or handling something that has bacteria on it. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.

MalaCards based summary : Septic Arthritis, also known as infectious arthritis, is related to mycobacterium kansasii and haemophilus influenzae, and has symptoms including sciatica, pruritus and muscle cramp. An important gene associated with Septic Arthritis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Akt Signaling and Integrin Pathway. The drugs Hyaluronic acid and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and bone, and related phenotypes are cardiovascular system and hematopoietic system

NIH Rare Diseases : 49 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery. Last updated: 3/31/2012

Disease Ontology : 12 An arthritis that involves infection by a pathogen located in joint.

Wikipedia : 72 Septic arthritis, also known as joint infection or infectious arthritis, is the invasion of a joint by... more...

Related Diseases for Septic Arthritis

Diseases related to Septic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 mycobacterium kansasii 30.6 CXCL8 TLR2
2 haemophilus influenzae 30.5 CXCL8 TLR2
3 endocarditis 30.2 CRP CXCL8 TLR2
4 synovitis 30.2 CRP CXCL8 MMP3
5 prosthetic joint infection 30.2 TLR2 TLR4
6 pneumonia 30.1 CRP CXCL8 TLR2 TLR4
7 otitis media 30.0 CXCL8 TLR2 TLR4
8 mycobacterium tuberculosis 1 30.0 CXCR3 TLR2 TLR4
9 brucellosis 30.0 CRP CXCL8 TLR4
10 osteoarthritis 30.0 CRP CXCL8 MMP3
11 rheumatoid arthritis 29.9 CRP CXCL8 MMP3 TLR2 TLR4
12 mycobacterium abscessus 29.9 CXCL8 TLR2
13 pyelonephritis 29.7 CRP CXCL8 TLR4
14 chorioamnionitis 29.6 CRP CXCL8 TLR4
15 peritonitis 29.6 CRP CXCL8 TLR2
16 bone inflammation disease 29.6 CRP CXCL8 MMP3
17 ophthalmia neonatorum 11.1
18 arthritis 11.0
19 trench fever 10.5 TLR2 TLR4
20 acute cervicitis 10.5 TLR2 TLR4
21 dental abscess 10.5 CRP TLR4
22 penicilliosis 10.5 TLR2 TLR4
23 myositis fibrosa 10.4 TLR2 TLR4
24 osteomyelitis 10.4
25 mycobacterium chelonae 10.4 CXCL8 TLR2
26 alveolar echinococcosis 10.4 TLR2 TLR4
27 pouchitis 10.4 CXCL8 TLR4
28 pyelitis 10.4 CRP TLR4
29 slow-channel congenital myasthenic syndrome 10.3 CRP CXCL8
30 pyuria 10.3 CRP CXCL8
31 conjunctivochalasis 10.3 MMP2 MMP3
32 suppurative otitis media 10.3 CRP TLR2 TLR4
33 mesenteric lymphadenitis 10.3 CRP TLR2
34 scrub typhus 10.3 CRP TLR2 TLR4
35 pelvic inflammatory disease 10.3 CRP TLR2 TLR4
36 cardiac rupture 10.3 CRP CXCL8
37 primary bacterial infectious disease 10.3 CRP TLR2 TLR4
38 acute transverse myelitis 10.3 CXCL8 MMP2
39 corneal ulcer 10.3 MMP2 MMP3
40 sorsby fundus dystrophy 10.3 MMP2 MMP3
41 lipid pneumonia 10.3 CRP CXCR3
42 louse-borne relapsing fever 10.3 CRP CXCL8
43 focal myositis 10.3 MMP2 MMP7
44 endometrial disease 10.3 CXCL8 TLR4
45 variola major 10.3 TLR3 TLR4
46 senile ectropion 10.2 MMP2 MMP7
47 internal hemorrhoid 10.2 MMP2 MMP7
48 neisseria meningitidis infection 10.2 TLR2 TLR4
49 adult astrocytic tumour 10.2 MMP3 MMP7
50 light chain deposition disease 10.2 MMP2 MMP7

Comorbidity relations with Septic Arthritis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to Septic Arthritis

Symptoms & Phenotypes for Septic Arthritis

UMLS symptoms related to Septic Arthritis:


sciatica, pruritus, muscle cramp, fever, back pain

MGI Mouse Phenotypes related to Septic Arthritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CRP TLR2 CXCR3 TLR3 MMP10 TLR4
2 hematopoietic system MP:0005397 9.92 MMP7 TLR2 CXCR3 ITGA2 TLR3 TLR4
3 homeostasis/metabolism MP:0005376 9.91 MMP7 CRP TLR2 CXCR3 ITGA2 TLR3
4 immune system MP:0005387 9.81 TLR2 CRP CXCR3 TLR3 MMP10 TLR4
5 neoplasm MP:0002006 9.43 TLR2 CXCR3 TLR3 TLR4 MMP2 MMP7
6 respiratory system MP:0005388 9.1 TLR2 CXCR3 TLR3 MMP10 TLR4 MMP2

Drugs & Therapeutics for Septic Arthritis

Drugs for Septic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
3
Cefazolin Approved Phase 4 25953-19-9 33255 656510
4
Dalbavancin Approved, Investigational Phase 4 171500-79-1, 91097-81-3 122186
5
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
6
Nafcillin Approved, Investigational Phase 4 147-52-4, 985-16-0 8982
7
Teicoplanin Approved, Investigational Phase 4 61036-62-2
8
Vancomycin Approved Phase 4 1404-90-6 14969 441141
9
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
10 Adjuvants, Immunologic Phase 4
11 Protective Agents Phase 4
12 Viscosupplements Phase 4
13 Anti-Infective Agents Phase 4,Early Phase 1
14 Anti-Infective Agents, Local Phase 4
15 Chlorhexidine gluconate Phase 4
16 Dermatologic Agents Phase 4
17 Disinfectants Phase 4
18 Anti-Bacterial Agents Phase 4,Early Phase 1
19 Antibiotics, Antitubercular Phase 4,Early Phase 1
20
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
21 Vaccines
22 Bone Density Conservation Agents
23 calcitonin
24 Calcitonin Gene-Related Peptide
25 Vasodilator Agents
26 Antibodies Early Phase 1
27 Immunoglobulins Early Phase 1

Interventional clinical trials:

(show all 21)

# Name Status NCT ID Phase Drugs
1 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
2 Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch Completed NCT01411891 Phase 4
3 Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Recruiting NCT03426761 Phase 4 Dalbavancin;Vancomycin
4 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
5 Surgical Lavage vs Serial Needle Aspiration for Infected Joints Withdrawn NCT00313365 Phase 3
6 Arthrocentesis Study Unknown status NCT02530229
7 ARTEMIS Synovial Markers in Arthritis Childhood Unknown status NCT02505828
8 Utilization of Leukocyte Esterase in the Diagnosis of Pediatric Joint Infections Unknown status NCT02032732
9 Ultrasonography Assessment of Septic Arthritis on Native Joint Completed NCT02018952
10 Use of Infrared Spectroscopy in Septic Arthritis Diagnosis Completed NCT02860871
11 Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF) Completed NCT01010165
12 Molecular Microbiology in Osteo-arthritis Infection Completed NCT01193803
13 The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries Completed NCT01333657
14 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
15 Procalcitonin Level and Kinetics in Children With Bacterial Infections Completed NCT00714402
16 Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques Recruiting NCT02565160
17 Operative and Non-operative Treatment of Traumatic Arthrotomies Recruiting NCT02841644
18 Pro-calcitonin for Early Detection of Septic Arthritis Active, not recruiting NCT02085733
19 Safety Study of Univers® Revers Shoulder Prosthesis Active, not recruiting NCT01778777
20 Ankle Joint Replacement Outcomes Study Active, not recruiting NCT00503438
21 Personalized Immunotherapeutic for Antibiotic-resistant Infection Enrolling by invitation NCT02508584 Early Phase 1

Search NIH Clinical Center for Septic Arthritis

Cochrane evidence based reviews: arthritis, infectious

Genetic Tests for Septic Arthritis

Anatomical Context for Septic Arthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Septic Arthritis:

18
Joint

MalaCards organs/tissues related to Septic Arthritis:

38
Testes, Bone, Myeloid, Colon, Kidney, Skin, Neutrophil

Publications for Septic Arthritis

Articles related to Septic Arthritis:

(show top 50) (show all 746)
# Title Authors Year
1
Current clinical and bacteriological profile of septic arthritis in young infants: a prospective study from a tertiary referral centre. ( 29427091 )
2018
2
Septic Arthritis of the Wrist. ( 29329124 )
2018
3
Bacteremia and Septic Arthritis due to a Nontoxigenic Strain of<i>Clostridium difficile</i>in a Patient With Sickle Cell Disease. ( 29410974 )
2018
4
Neutrophils: Beneficial and Harmful Cells in Septic Arthritis. ( 29401737 )
2018
5
Septic arthritis caused by Granulicatella adiacens after anterior cruciate ligament reconstruction. ( 29422445 )
2018
6
Validating an Algorithm to Predict Adjacent Musculoskeletal Infections in Pediatric Patients With Septic Arthritis. ( 29389760 )
2018
7
Neutralization of TNFR-1 and TNFR-2 modulates S. aureus induced septic arthritis by regulating the levels of pro inflammatory and anti inflammatory cytokines during the progression of the disease. ( 29339199 )
2018
8
Patient Factors Associated With Methicillin-Resistant Staphylococcus aureus Septic Arthritis in Children. ( 29451940 )
2018
9
Septic Arthritis, Osteomyelitis, and Pyomyositis in a Previously Healthy Infant. ( 29293205 )
2018
10
Host Factors Affect the Outcome of Arthroscopic Lavage Treatment of Septic Arthritis of the Knee. ( 29309715 )
2018
11
Group B streptococcus septic arthritis of the hip following spontaneous abortion. ( 29326375 )
2018
12
Don't put your foot in it: a case of talonavicular septic arthritis. ( 29374644 )
2018
13
Suture-induced arthritis as a clinical mimicker of septic arthritis. ( 29445456 )
2018
14
Isolated septic arthritis of hip joint: a rare presentation of melioidosis. A case report. ( 29351806 )
2018
15
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
16
Acute septic arthritis of the knee: A rare case report of infection with Parvimonas micra after an intra-articular corticosteroid injection for osteoarthritis. ( 29305995 )
2018
17
Arthroscopic Versus Open Treatment for Acute Septic Arthritis of the Knee in Children. ( 28945678 )
2017
18
Haemophilus influenzae serotype f endocarditis and septic arthritis. ( 28725560 )
2017
19
Clinical Characteristics and Outcomes in Polyarticular Septic Arthritis. ( 28917998 )
2017
20
Pathogen or contaminant? Distinguishing true infection from synovial fluid culture contamination in patients with suspected septic arthritis. ( 28766274 )
2017
21
Effect of arthroscopic lavage and repeated intra-articular administrations of antibiotic in adult horses and foals with septic arthritis. ( 28771839 )
2017
22
A rare complication of tonsillitis: septic arthritis of the temporomandibular joint. ( 28461120 )
2017
23
Mycobacterium avium Complex Septic Arthritis Presenting as Osteonecrosis of the Femoral Head in a Patient With Systemic Lupus Erythematosus. ( 28056158 )
2017
24
Surgical Management of Multijoint Septic Arthritis due to Rat-Bite Fever in a Pediatric Patient: A Case Study. ( 28255484 )
2017
25
Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study. ( 28862129 )
2017
26
Clinical significance of delta neutrophil index in the differential diagnosis between septic arthritis and acute gout attack within 24 hours after hospitalization. ( 28746185 )
2017
27
<i>S. lugdunensis</i> Native-Joint Septic Arthritis: Case Report and Review of the Literature. ( 29445553 )
2017
28
Lemierre's syndrome; a rare cause of septic arthritis. ( 28500126 )
2017
29
Peripheral Bacterial Septic Arthritis: Review of Diagnosis and Management. ( 28926460 )
2017
30
Concomitant crystal-induced and septic arthritis. ( 28725566 )
2017
31
Cervical facet joint septic arthritis: a real pain in the neck. ( 28775081 )
2017
32
Septic arthritis significantly increased the long-term mortality in geriatric patients. ( 28793879 )
2017
33
Predicting Periarticular Infection in Children With Septic Arthritis of the Hip: Regionally Derived Criteria May Not Apply to All Populations. ( 28060181 )
2017
34
Septic arthritis of the temporomandibular joint after acute otitis media in a child. ( 28944379 )
2017
35
<i>Pseudomonas aeruginosa</i> Septic Arthritis and Osteomyelitis after Closed Reduction and Percutaneous Pinning of a Supracondylar Humerus Fracture: A Case Report and Review of the Literature. ( 29348955 )
2017
36
The burden of septic arthritis on the U.S. inpatient care: A national study. ( 28809954 )
2017
37
Atypical osteomyelitis and concurrent septic arthritis due to Salmonella in immunocompetent children. ( 28951650 )
2017
38
Acute osteomyelitis and septic arthritis in children : AA referral hospital-based study in Iran. ( 28744778 )
2017
39
Ankylosis of the knee after septic arthritis following anterior cruciate ligament reconstruction in a 13-year-old male. ( 28342819 )
2017
40
Cutibacteriumacnes Septic Arthritis of the Nonoperated Knee: A Case Report. ( 28825032 )
2017
41
Spontaneous Bilateral Sternoclavicular Joint Septic Arthritis and Lumbar Discitis: An Unusual Case in a Healthy Adult. ( 29130010 )
2017
42
Imaging of Posttraumatic Arthritis, Avascular Necrosis, Septic Arthritis, Complex Regional Pain Syndrome, and Cancer Mimicking Arthritis. ( 28774452 )
2017
43
Septic arthritis in children: diagnosis and treatment. ( 29388627 )
2017
44
Outbreak of Septic Arthritis Associated with Intra-Articular Injections at an Outpatient Practice - New Jersey, 2017. ( 28749922 )
2017
45
Overwhelming Streptococcus pyogenes sepsis in an elderly patient with septic arthritis. ( 28882472 )
2017
46
Primary Septic Arthritis of The Knee due to Mycobacterium Tuberculosis in a Previously Healthy Child. ( 29301169 )
2017
47
Impact of cell wall peptidoglycan O-acetylation on the pathogenesis of Staphylococcus aureus in septic arthritis. ( 28802679 )
2017
48
Staphylococcus aureus-dependent septic arthritis in murine knee joints: local immune response and beneficial effects of vaccination. ( 27901071 )
2016
49
Key role of magnetic resonance imaging in the diagnosis of infections around the hip and pelvic girdle mimicking septic arthritis of the hip in children. ( 27007545 )
2016
50
Septic arthritis caused by Mycobacterium marinum infection. ( 27862193 )
2016

Variations for Septic Arthritis

Expression for Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for Septic Arthritis

Pathways related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 CXCL8 CXCR3 ITGA2 TLR2 TLR3 TLR4
2
Show member pathways
13.18 ITGA2 MMP10 MMP2 MMP3 MMP7
3
Show member pathways
12.64 CXCL8 TLR2 TLR3 TLR4
4
Show member pathways
12.51 ITGA2 MMP10 MMP2 MMP3 MMP7
5
Show member pathways
12.41 CXCL8 TLR2 TLR3 TLR4
6
Show member pathways
12.37 CXCL8 TLR2 TLR3 TLR4
7
Show member pathways
12.17 CXCL8 DEFB4A MMP3 TLR2
8
Show member pathways
12.12 CXCL8 TLR3 TLR4
9 12.12 ITGA2 MMP2 TLR2 TLR4
10
Show member pathways
12.07 CXCL8 TLR2 TLR3 TLR4
11 11.99 ITGA2 TLR2 TLR4
12
Show member pathways
11.95 CXCL8 DEFB4A TLR2 TLR4
13 11.92 TLR2 TLR3 TLR4
14
Show member pathways
11.89 TLR2 TLR3 TLR4
15 11.84 CXCL8 MMP2 MMP3
16
Show member pathways
11.79 TLR2 TLR3 TLR4
17 11.77 MMP2 MMP7 TLR2 TLR3 TLR4
18 11.74 CXCL8 TLR2 TLR4
19
Show member pathways
11.7 TLR2 TLR3 TLR4
20 11.68 MMP2 MMP3 MMP7
21
Show member pathways
11.66 MMP10 MMP2 MMP3 MMP7
22
Show member pathways
11.6 CXCL8 CXCR3 ITGA2 MMP10 MMP2 MMP3
23 11.58 CXCL8 MMP3 TLR2 TLR4
24
Show member pathways
11.52 CXCL8 MMP2 MMP3
25 11.49 ITGA2 TLR2 TLR3 TLR4
26 11.44 CXCL8 TLR2 TLR4
27 11.34 CXCL8 TLR2 TLR4
28 11.16 MMP2 TLR4
29 11.1 CXCL8 ITGA2 MMP2
30 11.02 TLR3 TLR4
31 10.91 CRP CXCL8
32 10.81 CXCL8 MMP10 MMP2 MMP3 MMP7

GO Terms for Septic Arthritis

Cellular components related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.87 CRP CXCL8 DEFB4A MMP10 MMP2 MMP3
2 extracellular matrix GO:0031012 9.56 MMP10 MMP2 MMP3 MMP7
3 extracellular space GO:0005615 9.5 CRP CXCL8 DEFB4A MMP10 MMP2 MMP3
4 proteinaceous extracellular matrix GO:0005578 9.46 MMP10 MMP2 MMP3 MMP7
5 intrinsic component of plasma membrane GO:0031226 9.37 TLR2 TLR4
6 cell surface GO:0009986 9.1 CXCR3 ITGA2 MMP7 TLR2 TLR3 TLR4

Biological processes related to Septic Arthritis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.96 CXCL8 DEFB4A TLR2 TLR4
2 positive regulation of gene expression GO:0010628 9.92 CRP TLR2 TLR3 TLR4
3 response to hypoxia GO:0001666 9.83 ITGA2 MMP2 TLR2
4 chemotaxis GO:0006935 9.82 CXCL8 CXCR3 DEFB4A
5 defense response GO:0006952 9.81 CXCL8 DEFB4A TLR3
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 TLR2 TLR3 TLR4
7 defense response to Gram-positive bacterium GO:0050830 9.77 CRP DEFB4A TLR2
8 positive regulation of tumor necrosis factor production GO:0032760 9.72 TLR2 TLR3 TLR4
9 positive regulation of interleukin-6 production GO:0032755 9.71 TLR2 TLR3 TLR4
10 toll-like receptor signaling pathway GO:0002224 9.7 TLR2 TLR3 TLR4
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TLR2 TLR4
12 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.67 TLR3 TLR4
13 positive regulation of interleukin-8 production GO:0032757 9.67 TLR2 TLR3 TLR4
14 extracellular matrix disassembly GO:0022617 9.67 MMP10 MMP2 MMP3 MMP7
15 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.66 TLR3 TLR4
16 positive regulation of interleukin-10 production GO:0032733 9.65 TLR2 TLR4
17 positive regulation of interferon-beta production GO:0032728 9.65 TLR2 TLR3 TLR4
18 negative regulation of osteoclast differentiation GO:0045671 9.64 TLR3 TLR4
19 necroptotic process GO:0070266 9.63 TLR3 TLR4
20 positive regulation of interleukin-12 production GO:0032735 9.63 TLR2 TLR3 TLR4
21 microglial cell activation GO:0001774 9.62 TLR2 TLR3
22 cellular response to mechanical stimulus GO:0071260 9.62 ITGA2 MMP7 TLR3 TLR4
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 TLR2 TLR4
24 response to molecule of bacterial origin GO:0002237 9.61 CXCL8 TLR2
25 positive regulation of NF-kappaB import into nucleus GO:0042346 9.61 TLR2 TLR3 TLR4
26 regulation of cytokine secretion GO:0050707 9.6 TLR2 TLR4
27 cellular response to lipoteichoic acid GO:0071223 9.58 TLR2 TLR4
28 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.58 TLR3 TLR4
29 positive regulation of chemokine production GO:0032722 9.58 TLR2 TLR3 TLR4
30 positive regulation of interferon-beta biosynthetic process GO:0045359 9.57 TLR3 TLR4
31 positive regulation of toll-like receptor signaling pathway GO:0034123 9.56 TLR2 TLR3
32 positive regulation of inflammatory response GO:0050729 9.56 ITGA2 TLR2 TLR3 TLR4
33 regulation of dendritic cell cytokine production GO:0002730 9.51 TLR3 TLR4
34 I-kappaB phosphorylation GO:0007252 9.33 TLR2 TLR3 TLR4
35 collagen catabolic process GO:0030574 9.26 MMP10 MMP2 MMP3 MMP7
36 inflammatory response GO:0006954 9.1 CRP CXCL8 CXCR3 TLR2 TLR3 TLR4

Molecular functions related to Septic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.67 MMP10 MMP2 MMP3 MMP7
2 serine-type endopeptidase activity GO:0004252 9.56 MMP10 MMP2 MMP3 MMP7
3 lipopolysaccharide binding GO:0001530 9.32 TLR2 TLR4
4 metallopeptidase activity GO:0008237 9.26 MMP10 MMP2 MMP3 MMP7
5 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
6 metalloendopeptidase activity GO:0004222 8.92 MMP10 MMP2 MMP3 MMP7

Sources for Septic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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