Summaries for Septic Arthritis

Sources:
6Disease Ontology, 30NIH Rare Diseases, 23MedlinePlus, 44Wikipedia, 22MalaCards
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Export this MalaCard
MedlinePlus: Most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. infectious arthritis is an infection in the joint. the infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. besides the usual arthritis symptoms, it can cause chills and fever. one type of infectious arthritis is reactive arthritis. it is inflammation of a joint in reaction to an infection somewhere else in your body. the joint is usually the knee, ankle, or toe. the infection that causes reactive arthritis is often in the bladder, urethra (urine tube), or for women, in the vagina. sexually transmitted or food-borne bacteria can cause reactive arthritis. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery.23

MalaCards: Septic Arthritis, also known as infectious arthritis, is related to juvenile rheumatoid arthritis and psoriatic arthritis. An important gene associated with Septic Arthritis is NAA11 (N(alpha)-acetyltransferase 11, NatA catalytic subunit), and among its related pathways are Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response and Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway. The drugs meclofenamate sodium and devils claw and the compounds ivig and sp 600125 have been mentioned in the context of this disorder. Affiliated tissues include joint, myeloid and b cells, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Disease Ontology: An arthritis that involves infection by a pathogen located in joint.6

NIH Rare Diseases: Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. Depending on the type of infection, one or more joints may be affected. Certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. In reactive arthritis, joint inflammation develops weeks, months or even years after the infection. Reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. To diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. Treatment includes medicines and sometimes surgery.30

Wikipedia: Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis....44 more...

Aliases & Descriptions for Septic Arthritis

Sources:
6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 23MedlinePlus, 43UMLS, 32Novoseek , 40SNOMED-CT, 19ICD9CM, 27NCIt, 24MeSH
See all sources

Aliases & Descriptions:

septic arthritis 6 30 8
infectious arthritis 6 30 23
acute suppurative arthritis due to bacteria 43
arthritis, infectious 43
arthritis septic 32
arthritis 43

Related Diseases for Septic Arthritis

Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to septic arthritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 653)
idRelated DiseaseScoreTop Affiliating Genes
1juvenile rheumatoid arthritis35.2TNF, TNFRSF1B, CRP
2psoriatic arthritis35.0IL1B, TNF, TNFRSF1B, CRP, TLR2
3rheumatoid arthritis34.0RELA, ITGA2, MMP2, MMP9, MEFV, IL1B
4ankylosing spondylitis32.3TNF, TNFRSF1B, CRP, TLR4
5systemic lupus erythematosus32.0IFNG, TNF, TNFRSF1B, CRP, TLR2, TLR4
6rheumatoid arthritis, association with30.6MMP9, IL1B, IFNG, TNF, TNFRSF1B, CRP
7tuberculosis30.0IL1B, IFNG, TNF, TLR4
8spondylarthropathy29.7TNF, CRP, TLR4
9synovitis29.7MMP2, MMP9, IL1B, TNF, TNFRSF1B, CRP
10osteoarthritis29.6RELA, MMP2, MMP9, IL1B, IFNG, TNF
11spondyloarthropathy29.5IL1B, IFNG, TNF, CRP
12familial mediterranean fever29.5MEFV, TNF
13pyogenic arthritis, pyoderma gangrenosum and acne29.5MEFV, IL1B
14blindness29.5LACTB, MMP9, IL1B, IFNG, TNF, TNFRSF1B
15periodontitis29.2MMP9, IL1B, TNF, TLR2, TLR4, DEFB4A
16blau syndrome29.1MEFV, IL1B, TNF
17immunodeficiency28.8IFNG, TNF, TLR2, TLR4, TLR9, CXCR3
18adult-onset still's disease28.5IL1B, TNF, TNFRSF1B, CRP
19anemia28.4RELA, LACTB, ITGA2, MEFV, IL1B, IFNG
20spondylitis28.2RELA, MEFV, IL1B, IFNG, TREM1, TNF
21lupus erythematosus28.2ITGA2, MMP2, MMP9, IL1B, IFNG, TREM1
22polymyalgia rheumatica28.1IL1B, IFNG, TNF, CRP
23osteoporosis28.0MMP9, IL1B, IFNG, TNF, TNFRSF1B, CRP
24amyloidosis27.9MMP9, MEFV, IL1B, IFNG, TNF, CRP
25psoriasis27.7MMP2, MMP9, IL1B, CCL18, IFNG, TNF
26connective tissue disease27.6IFNG, TNF, TNFRSF1B, CRP
27encephalitis27.3IL1B, IFNG, TNF, CRP, TLR2, TLR3
28palindromic rheumatism27.3MEFV, IL1B, TNF, TNFRSF1B
29crohn's disease27.2IL1B, IFNG, TNF, TNFRSF1B, TLR2, TLR4
30reactive arthritis27.1IL1B, IFNG, TNF, CRP, TLR2, TLR4
31hepatitis c27.1IFNG, TNF, TNFRSF1B, TLR2, TLR3, TLR4
32uveitis27.1IL1B, CCL18, IFNG, TNF, TNFRSF1B, CRP
33vasculitis26.9MMP2, MMP9, MEFV, IL1B, IFNG, TNF
34mixed connective tissue disease26.7TNF, TNFRSF1B, CRP
35klebsiella26.7LACTB, MMP9, IL1B, TNF, TLR2, TLR4
36ischemic heart disease26.7MMP9, IL1B, TNF, CRP
37behcet's disease26.7MEFV, TNF, TNFRSF1B, CRP
38back pain26.7MMP9, IL1B, TNF
39collagen disease26.6IFNG, TNF, CRP
40allergic asthma26.4IFNG, TLR2, TLR4, TLR9
41appendicitis26.4LACTB, CRP
42invasive aspergillosis26.4TLR2, TLR4
43cryoglobulinemia26.2IL1B, IFNG, TNF, TLR2
44rheumatic fever26.0IL1B, TNF, CRP, TLR2
45epidural abscess25.9TNF, CRP
46scleritis25.8MMP9, IFNG, TNF, TNFRSF1B
47atopic dermatitis25.8CCL18, IFNG, TNF, TLR2, TLR4, TLR9
48homocysteine25.8RELA, ITGA2, MMP2, MMP9, IFNG, TNF
49graves' disease25.7IL1B, IFNG, TNF, CRP, CXCR3
50arthropathy25.7MMP2, IL1B, IFNG, TNF, TNFRSF1B, CRP

Graphical network of the top 20 diseases related to septic arthritis:



Graphical network of diseases related to septic arthritis

Clinical Features for Septic Arthritis

Drugs & Therapeutics for Septic Arthritis

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for septic arthritis

Drug clinical trials:

Search ClinicalTrials for septic arthritis

Search NIH Clinical Center for septic arthritis

Search CenterWatch for septic arthritis

Inferred drug relations via UMLS/NDF-RT:

43 28 devils claw, meclofenamate, meclofenamate sodium, salsalate

Genetic Tests for Septic Arthritis

Anatomical Context for Septic Arthritis

Sources:
11FMA, 22MalaCards
See all sources

MalaCards organs/tissues related to septic arthritis:

22
Myeloid, B cells

FMA organs/tissues related to septic arthritis:

11
Joint

Phenotypes for genes affiliated with Septic Arthritis

Sources:
25MGI
See all sources

Publications for genes affiliated with Septic Arthritis

Sources:
35PubMed
See all sources

Articles related to septic arthritis:

(show all 18)
idTitleAuthorsYearAffiliating Genes
1The catabolic role of toll-like receptor 2 (TLR-2) me diated by the NF-I_B pathway in septic arthritis. (20740673)Papathanasiou I.... Tsezou A.2011RELA, TLR2
2The antimicrobial peptide HBD-2 and the Toll-like rec eptors-2 and -4 are induced in synovial membranes in case of septic arthritis. (19412702)Varoga D.... Pufe T.2009TLR2, TLR4, DEFB4A
3Elevated synovial expression of triggering receptor e xpressed on myeloid cells 1 in patients with septic arthritis or rheumatoid art hritis. (19054829)Collins C.E.... Stohl W.2009TREM1
4USA300 is the predominant genotype causing Staphyloco ccus aureus septic arthritis in children. (19820424)Carrillo-Marquez M.A.... Kaplan S.L.2009CRP
5Procalcitonin, C-reactive protein, and complement-3a assays in synovial fluid for diagnosing septic arthritis: preliminary results. (18178503)Streit G.... Wendling D.2008CRP
6Serum procalcitonin for discrimination between septic and non-septic arthritis. (18578968)HA1gle T.... Daikeler T.2008CRP
7Septic arthritis due to extended spectrum beta lactamase producing Klebsiella pneumoniae. (17433752)Schelenz S.... Goldsmith D.2007LACTB
8Clinical correlation with the PA/plasmin system in septic arthritis of the knee. (16505706)Hsieh Y.S.... Lu K.H.2006MMP2, PLAU
9Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis. (16697230)Calander A.M.... Tarkowski A.2006MMP9
10Familial Mediterranean fever mimicking septic arthritis. (15700115)Uthman I.... Bizri A.R.2005MEFV
11Test characteristics of C-reactive protein (CRP) for pediatric septic arthritis. (15105739)Brown M.D.2004CRP
12Clinical significance of gelatinases in septic arthritis of native and replaced knees. (15552155)Chu S.C.... Lu K.H.2004MMP2
13Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-gamma in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids. (14996826)Proost P.... Van Damme J.2004TLR3, TLR2, TLR4
14Assessment of the test characteristics of C-reactive protein for septic arthritis in children. (12724603)Levine M.J.... Flynn J.M.2003CRP
15Acute septic arthritis of the hip in children in northern Australia. (12608977)Gandini D.2003CRP
16Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclear leukocytes in synergy with IFN-gamma and provide a mechanism for enhanced synovial chemokine levels in septic arthritis. (14579283)Proost P.... Van Damme J.2003TLR2, TLR4
17IL-1beta, IL-6 and TNF-alpha in synovial fluid of patients with non-gonococcal septic arthritis. (10219896)Osiri M.... Deesomchok U.1998TNF, IL1B
18A collagen receptor on Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. (8382334)Switalski L.M.... Hook M.1993ITGA2

Expression for genes affiliated with Septic Arthritis

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Septic Arthritis

Pathways for genes affiliated with Septic Arthritis

Sources:
10EMD Millipore, 41Thomson Reuters, 36QIAGEN, 37R&D Systems, 20KEGG, 3Cell Signaling Technology
See all sources

Pathways related to septic arthritis according to GeneDecks:

(show top 50)    (show all 70)
idPathwayScoreTop Affiliating Genes
1Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response1010.5CXCL11, TLR5
2Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway4110.1RELA
3Bacterial infections in CF airways4110.0RELA, TLR2, TLR5, DEFB4A
4Toll-Like Receptors Pathway369.7TLR9, TLR5, TLR4, TLR3, TLR2
5Immune response_TLR signaling pathways419.5CXCL11, TLR9, TLR5, TLR4, TLR2, RELA
6Phagocytosis of Microbes369.4TLR9, TLR5, TLR4, TLR3, TLR2, ITGA2
7Transcription_NF-kB signaling pathway419.4RELA, TNF, TNFRSF1B, TLR4
8Akt Signaling369.3CXCR3, CXCL11, TNF, CCL18, ITGA2
9Th17 Differentiation379.1TLR9, TLR5, TLR4, TLR3, TLR2, IL1B
10Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway109.1TNFRSF1B, TNF, RELA
11NOD-like receptor signaling pathway209.0TNF, IL1B, MEFV, RELA
12MIF Mediated Glucocorticoid Regulation369.0CXCL11, TLR4, TNF, CCL18, IL1B
13MIF Regulation of Innate Immune Cells369.0CXCL11, TLR4, TNF, CCL18, IL1B
14TREM1 Pathway369.0TLR9, TLR5, TLR4, TLR3, TLR2, TREM1
15Immune response_MIF-mediated glucocorticoid regulation418.9TNF, IFNG, RELA
16Pertussis208.9RELA, IL1B, TNF, TLR4
17PEDF Induced Signaling368.9RELA, IL1B, CCL18, TNF, CXCL11
18Immune response MIF-mediated glucocorticoid regulation108.9TNF, IFNG, RELA
19Cellular Transformation by HTLV1368.9RELA, IFNG, TNF, TNFRSF1B
20Inflammasome Activation Pathways378.8TLR9, TLR5, TLR4, TLR3, TLR2, IL1B
21Transendothelial Migration of Leukocytes368.8CXCR3, CXCL11, CCL18, MMP9, MMP2, ITGA2
22Toll-Like Receptor Signaling Pathways378.8TLR9, TLR5, TLR4, TLR3, TLR2, IL1B
23STAT3 Pathway368.8CXCR3, CXCL11, TNFRSF1B, TNF, CCL18, IL1B
24Tec Kinases Signaling368.8CXCR3, TLR9, TLR5, TLR4, TLR3, TLR2
25Immune response_Bacterial infections in normal airways418.8DEFB4A, TLR5, IFNG, IL1B, RELA
26African trypanosomiasis208.6IL1B, IFNG, TNF, TLR9
27Toxoplasmosis208.6TLR4, TLR2, TNF, IFNG, RELA
28HMGB1 Pathway368.5IL1B, IFNG, TNF, TLR4
29Antioxidant Action of Vitamin-C368.5CXCR3, CXCL11, TNFRSF1B, TNF, CCL18, IL1B
30p38 Signaling368.5IL1B, CCL18, TNF, TNFRSF1B, CXCL11, CXCR3
31Th1 Differentiation378.4TLR2, TLR3, TLR4, TLR5, TLR9, TNF
32MSP-RON Signaling368.4TLR4, TLR2, TNF, IFNG, IL1B
33TRAF Pathway368.4TLR9, TLR5, TLR4, TLR3, TLR2, TNFRSF1B
34Measles208.4TLR9, TLR4, TLR2, IFNG, IL1B, RELA
35IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types378.3TLR9, TLR5, TLR4, TLR3, TLR2, IFNG
36Immune response_MIF in innate immunity response418.3TLR4, TNF, IFNG, IL1B, RELA
37Immune response MIF in innate immunity response108.3TLR4, TNF, IFNG, IL1B, RELA
38Rheumatoid arthritis208.3TLR4, TLR2, TNF, IFNG, IL1B
39NF-kappaB Signaling38.2TLR9, TLR4, TLR3, TLR2, TNFRSF1B, TNF
40Malaria208.2TLR9, TLR4, TLR2, TNF, IFNG, IL1B
41Toll-like receptor signaling pathway208.2CXCL11, TLR9, TLR5, TLR4, TLR3, TLR2
42Leishmaniasis208.1TLR4, TLR2, TNF, IFNG, IL1B, RELA
43Influenza A208.1TLR4, TLR3, TNF, IFNG, IL1B, RELA
44Amoebiasis208.1TLR4, TLR2, TNF, IFNG, IL1B, RELA
45NF-KappaB (p50-p65) Pathway368.0TLR9, TLR5, TLR4, TLR3, TLR2, TNFRSF1B
46NF-KappaB Family Pathway368.0TLR9, TLR5, TLR4, TLR3, TLR2, TNFRSF1B
47Cytokine-cytokine receptor interaction208.0CXCR3, CXCL11, TNFRSF1B, TNF, IFNG, CCL18
48Chagas disease (American trypanosomiasis)207.9TLR9, TLR4, TLR2, TNF, IFNG, IL1B
49Tuberculosis207.9TLR9, TLR4, TLR2, TNF, IFNG, IL1B
50Colorectal Cancer Metastasis367.5TLR9, TLR5, TLR4, TLR3, TLR2, TNF

Compounds for genes affiliated with Septic Arthritis

Sources:
32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
See all sources

Compounds related to septic arthritis according to GeneDecks:

(show top 50)    (show all 134)
idCompoundScoreTop Affiliating Genes
1ivig32 10.6CRP
2sp 60012532 42 11.4DEFB4A, TLR2
3loxoribine32 9.9TLR5, TLR2, TLR9, TLR4
4calcitriol32 42 9 18 9 13.7PLAU, TLR2
5pge232 9.6PLAU, TNFRSF1B, TLR2, TLR4
6hbd232 9.5DEFB4A, TLR2, IL1B, TLR4
7histamine32 18 10.4DEFB4A, TLR4, TLR2, PLAU, CXCR3
8endotoxin32 9.2TLR9, DEFB4A, CXCR3, TNFRSF1B, TLR3, CRP
9polyinosinic-polycytidylic acid32 9.1TLR3, TLR9, TLR4, TLR2, IFNG
10gabexate mesilate32 9.0PLAU, CRP, MMP9, TNF
11tarc32 8.9CCL18, CXCR3, TNF, IFNG, CXCL11
12imiquimod32 42 9 9 11.9IFNG, TLR4, TLR3, TNF
13chloroquine32 34 9 9 11.8TNFRSF1B, TNF, TLR9, TLR4, PLAU
14parthenolide32 8.7IFNG, MMP9, PLAU
15flagellin32 8.7DEFB4A, TLR2, TLR3, TLR4, CXCR3, TLR9
16aminoguanidine32 9 9 10.5IL1B, PLAU, TLR4, IFNG
17lipoteichoic acid32 8.4IL1B, TNF, TLR2, TLR4, TLR5, TLR9
18peptidoglycan32 8.4TLR3, TLR9, DEFB4A, IL1B, TLR5, TLR2
19polymyxin b32 8.4IL1B, IFNG, TNF, TLR4, TLR2
20atorvastatin32 34 9 18 9 12.3TLR4, MMP9, PLAU, CRP, MMP2, TNF
21vegf32 8.2MMP9, CCL18, TNFRSF1B, CRP, PLAU, ITGA2
22wortmannin32 42 9.2MMP2, CXCR3, TLR4, TLR3, TLR2, MMP9
23neopterin32 8.1IL1B, IFNG, TNFRSF1B, TNF, CRP
24etanercept32 9 9 10.1IL1B, CXCR3, CRP, TNFRSF1B, TNF, IFNG
25simvastatin32 34 42 9 18 9 13.0MMP9, IFNG, TLR4, TLR2, CRP, TNF
26tgf beta132 8.0MMP2, PLAU, TLR4, TNF, IL1B, MMP9
27il 1032 7.9CXCR3, TLR4, TLR2, TNFRSF1B, TNF, IFNG
28fibrinogen32 7.9TNFRSF1B, ITGA2, MMP9, TLR4, PLAU, CRP
29curcumin32 7.9TNF, TNFRSF1B, PLAU, IL1B, MMP9, MMP2
30sb 20358032 42 8.9MMP9, MMP2, TNF, CRP, PLAU, IFNG
31poly(i-c)32 7.8TLR9, TLR4, TLR3, TNF, TLR2, IFNG
32methotrexate32 34 42 9 9 11.8CRP, TNF, TNFRSF1B, IL1B, MMP9, MMP2
33infliximab32 9 9 9.8TNFRSF1B, TLR4, IFNG, TNF, CXCR3, IL1B
34hydrocortisone32 9 9 9.8PLAU, IFNG, IL1B, CXCR3, TNF, MMP2
35pd 98,05932 7.7IL1B, CXCR3, MMP2, MMP9, DEFB4A, TLR2
36n acetylcysteine32 7.6PLAU, CRP, TNF, IL1B, TLR4, MMP9
37ly29400232 7.5TLR4, CXCR3, TLR3, CRP, TNFRSF1B, TNF
38herbimycin a32 42 8.4MMP9, IL1B, PLAU, MMP2, TNF, IFNG
39phosphatidylinositol32 7.4PLAU, MMP9, MMP2, ITGA2, TLR2, TLR3
40pdtc32 7.3IL1B, IFNG, TNF, PLAU, TLR4, MMP9
41ccl332 7.1MMP9, IL1B, IFNG, TNF, TLR2, TLR4
42actinomycin d32 7.1TLR4, TLR2, PLAU, TNFRSF1B, TNF, IFNG
43nitric oxide32 9 18 9 10.0TNFRSF1B, IFNG, TNF, IL1B, TLR2, TLR3
44genistein32 9 18 9 10.0IL1B, MMP9, MMP2, TNF, PLAU, DEFB4A
45tyrosine32 7.0TLR4, PLAU, TLR2, TLR3, TLR9, DEFB4A
46dexamethasone32 42 34 9 9 10.6MMP9, IL1B, CCL18, IFNG, CXCR3, CXCL11
47serine32 6.6TLR3, TLR4, TLR9, PLAU, CXCR3, TLR2
48rantes32 6.2IL1B, TNFRSF1B, MMP9, CCL18, IFNG, TNF
49cycloheximide32 6.1ITGA2, IFNG, CRP, TNFRSF1B, TNF, TLR4
50retinoic acid32 42 18 8.0TLR3, PLAU, TNFRSF1B, TNF, IFNG, IL1B

GO Terms for genes affiliated with Septic Arthritis

Sources:
12Gene Ontology
See all sources

Cellular components related to septic arthritis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome membraneGO:0360209.7TLR9, TLR3
2cell surfaceGO:0099868.7ITGA2, TNF, PLAU, TLR2, TLR3
3external side of plasma membraneGO:0098978.1ITGA2, CXCR3, TLR4, TLR2, TNF, IFNG
4extracellular spaceGO:0056156.5CXCL11, PLAU, CRP, TNF, IFNG, CCL18
5extracellular regionGO:0055766.2CXCL11, DEFB4A, TLR9, PLAU, CRP, TNFRSF1B

Biological processes related to septic arthritis according to GeneDecks:

(show top 50)    (show all 52)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-18 productionGO:03274110.3TLR2, TLR9
2positive regulation of interferon-alpha biosynthetic processGO:04535610.3TLR9, TLR3
3pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseGO:05203310.2TLR4, TLR3
4positive regulation of interferon-beta biosynthetic processGO:04535910.2TLR9, TLR4, TLR3
5microglial cell activation involved in immune responseGO:00228210.1TLR3, TLR4
6positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.1TLR9, TLR4, TLR2
7positive regulation of macrophage cytokine productionGO:06090710.1TLR4, TLR2
8positive regulation of toll-like receptor signaling pathwayGO:03412310.0TLR9, TLR5, TLR3, TLR2
9I-kappaB phosphorylationGO:0072529.9TLR2, TLR3, TLR4, TLR9
10positive regulation of interferon-beta productionGO:0327289.9TLR2, TLR3, TLR4, TLR9
11positive regulation of inflammatory responseGO:0507299.9TLR9, TLR4, TLR3, TLR2
12negative regulation of interleukin-6 productionGO:0327159.8TLR9, TLR4, TNF
13MyD88-dependent toll-like receptor signaling pathwayGO:0027559.8TLR5, TLR4, TLR2, RELA
14Toll signaling pathwayGO:0080639.8RELA, TLR2, TLR3, TLR4
15toll-like receptor 4 signaling pathwayGO:0341429.8TLR4, TLR3, TLR2, RELA
16chemotaxisGO:0069359.6CCL18, PLAU, DEFB4A, CXCL11, CXCR3
17negative regulation of lipid storageGO:0108889.6CRP, TNF
18chronic inflammatory response to antigenic stimulusGO:0024399.6IL1B, TNF
19sequestering of triglycerideGO:0307309.6IL1B, TNF
20cellular response to mechanical stimulusGO:0712609.6TLR5, TLR4, TLR3, IL1B
21positive regulation of heterotypic cell-cell adhesionGO:0341169.5TNF, IL1B
22negative regulation of interleukin-17 productionGO:0327009.5IFNG, TLR2, TLR4
23positive regulation of interleukin-12 biosynthetic processGO:0450849.5TLR4, IFNG
24positive regulation of chemokine productionGO:0327229.4TLR9, TLR4, TLR3, TLR2, TNF
25positive regulation of vitamin D biosynthetic processGO:0605579.4IFNG, TNF
26positive regulation of interferon-gamma productionGO:0327299.3TLR4, TNF, IL1B
27negative regulation of growth of symbiont in hostGO:0441309.2TLR2, TNF, IFNG
28lipopolysaccharide-mediated signaling pathwayGO:0316639.2TLR4, TLR2, TNF, IL1B
29positive regulation of interleukin-8 productionGO:0327579.2TLR9, TLR5, TLR4, TLR3, TLR2, IL1B
30defense response to bacteriumGO:0427429.1IFNG, TLR3, TLR4, TLR9, DEFB4A
31humoral immune responseGO:0069599.1TNF, TREM1, IFNG
32positive regulation of interleukin-12 productionGO:0327359.1TLR9, TLR4, TLR3, TLR2, IFNG
33positive regulation of tumor necrosis factor productionGO:0327609.1TLR9, TLR4, TLR3, TLR2, IFNG
34immune responseGO:0069559.1CXCL11, DEFB4A, TLR4, TLR2, CCL18
35innate immune responseGO:0450879.1DEFB4A, TLR9, TLR5, TLR4, TLR3, TLR2
36positive regulation of JNK cascadeGO:0463309.1TLR9, TLR4, TLR3, TNF, IL1B
37positive regulation of interleukin-6 biosynthetic processGO:0454109.0IL1B, IFNG
38cellular response to lipopolysaccharideGO:0712229.0IFNG, TNFRSF1B, TLR4
39positive regulation of calcidiol 1-monooxygenase activityGO:0605598.9TNF, IFNG, IL1B
40positive regulation of NF-kappaB import into nucleusGO:0423468.8TLR9, TLR4, TLR3, TLR2, TNF, IL1B
41positive regulation of interleukin-6 productionGO:0327558.8TLR9, TLR4, TLR3, TLR2, TNF, IL1B
42positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431238.7TLR9, TLR4, TLR3, TNF, IL1B, RELA
43positive regulation of chemokine biosynthetic processGO:0450808.7TLR3, TNF, IFNG, IL1B
44positive regulation of apoptotic processGO:0430658.7TLR4, TLR3, TNF, IL1B, MMP9
45positive regulation of membrane protein ectodomain proteolysisGO:0510448.6TNFRSF1B, TNF, IFNG, IL1B
46response to hypoxiaGO:0016668.5TLR4, CRP, TNF, IL1B, MMP9
47positive regulation of NF-kappaB transcription factor activityGO:0510928.5TLR9, TLR4, TLR3, TLR2, TNF, IL1B
48positive regulation of nitric oxide biosynthetic processGO:0454298.4IL1B, IFNG, TNF, TLR2, TLR4
49positive regulation of transcription from RNA polymerase II promoterGO:0459447.6TLR9, TLR4, TLR3, TLR2, TNF, IFNG
50inflammatory responseGO:0069547.4RELA, CXCL11, TLR9, TLR5, TLR3, TLR2

Molecular functions related to septic arthritis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Gram-positive bacterial cell surface bindingGO:0516379.9CRP, TLR2
2lipopolysaccharide receptor activityGO:0018759.7TLR2, TLR4
3interleukin-1 receptor bindingGO:0051499.3IL1B, TLR5, TLR9

Sources for Septic Arthritis

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS