MCID: SPT004
MIFTS: 53

Septic Arthritis malady

Rare diseases, Bone diseases categories
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Summaries for Septic Arthritis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. infectious arthritis is an infection in the joint. the infection comes from a bacterial, viral, or fungal infection that spreads from another part of the body. symptoms of infectious arthritis include intense pain in the joint joint redness and swelling chills and fever inability to move the area with the infected joint one type of infectious arthritis is reactive arthritis. the reaction is to an infection somewhere else in your body. the joint is usually the knee, ankle, or toe. sometimes, reactive arthritis is set off by an infection in the bladder, or in the urethra, which carries urine out of the body. in women, an infection in the vagina can cause the reaction. for both men and women, it can start with bacteria passed on during sex. another form of reactive arthritis starts with eating food or handling something that has bacteria on it. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery.

MalaCards: Septic Arthritis, also known as infectious arthritis, is related to arthritis and rheumatoid arthritis. An important gene associated with Septic Arthritis is CXCL11 (chemokine (C-X-C motif) ligand 11), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and CXCR3-mediated signaling events. The compounds tarc and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and bone.

Disease Ontology:8 An arthritis that involves infection by a pathogen located in joint.

NIH Rare Diseases:43 Infectious arthritis is joint pain, soreness, stiffness and swelling caused by a bacterial, viral, or fungal infection that spreads from another part of the body. depending on the type of infection, one or more joints may be affected. certain bacteria can cause a form of infectious arthritis called reactive arthritis, which appears to be caused by the immune system reacting to bacteria, rather than by the infection itself. in reactive arthritis, joint inflammation develops weeks, months or even years after the infection. reactive arthritis happens most commonly after infections of the genital and gastrointestinal tracts. to diagnose infectious arthritis, your health care provider may do tests of your blood, urine, and joint fluid. treatment includes medicines and sometimes surgery. last updated: 3/31/2012

Wikipedia:65 Septic arthritis is the purulent invasion of a joint by an infectious agent which produces arthritis.... more...

Aliases & Classifications for Septic Arthritis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


Aliases & Descriptions:

septic arthritis 8 43 10
infectious arthritis 8 43 34
acute suppurative arthritis due to bacteria 62
arthritis, infectious 62
arthritis septic 45


Related Diseases for Septic Arthritis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Septic Arthritis:



Diseases related to septic arthritis

Symptoms for Septic Arthritis

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Drugs & Therapeutics for Septic Arthritis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Septic Arthritis

Search NIH Clinical Center for Septic Arthritis

Genetic Tests for Septic Arthritis

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Anatomical Context for Septic Arthritis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Septic Arthritis:

33
Testes, Bone, Skin, Liver, Colon, Myeloid, Cervix

FMA organs/tissues related to Septic Arthritis:

14
Joint

Animal Models for Septic Arthritis or affiliated genes

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Publications for Septic Arthritis

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Sources:
52PubMed
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Articles related to Septic Arthritis:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
Three Cases of Postoperative Septic Arthritis Caused by Mycobacterium conceptionense in Shoulder Joints of Immunocompetent Patients. (24391195)
2014
2
The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis. (24308337)
2014
3
A case of unusual Gram-negative bacilli septic arthritis in an immunocompetent patient. (24005465)
2013
4
Septic arthritis: patients with or without isolated infectious agents have similar characteristics. (24318567)
2013
5
Twelve-month outcome following septic arthritis in children. (23531603)
2013
6
Management of septic arthritis following anterior cruciate ligament reconstruction: a review of current practices and recommendations. (24187034)
2013
7
Neonatal hip septic arthritis: ultrasound should not influence decision to aspirate. (23960065)
2013
8
Salmonella septic arthritis of the knees in a patient with systemic lupus erythematosus. (23753601)
2013
9
Treatment of acute septic arthritis. (23439494)
2013
10
Risk of septic arthritis after intra-articular medication: a study of 16,624 injections in Thoroughbred racehorses. (23782019)
2013
11
Selective IgM deficiency in an adult presenting withA Streptococcus pneumoniae septic arthritis. (23523054)
2013
12
Antimicrobial management of septic arthritis of the hand and wrist. (24307329)
2013
13
MRI findings of treated bacterial septic arthritis. (22430565)
2012
14
Pantoea agglomerans foreign body-induced septic arthritis. (22926215)
2012
15
Septic arthritis of the knee: the use and effect of antibiotics prior to diagnostic aspiration. (22943233)
2012
16
Streptococcus gordonii septic arthritis: two cases and review of literature. (22974507)
2012
17
Gentamicin in combination with ascorbic acid regulates the severity of Staphylococcus aureus infection-induced septic arthritis in mice. (22924656)
2012
18
Sternoclavicular joint septic arthritis and osteomyelitis caused by Aggregatibacter aphrophilus. (22223671)
2012
19
Septic arthritis. (22100289)
2011
20
Possible protective role of chloramphenicol in TSST-1 and coagulase-positive Staphylococcus aureus-induced septic arthritis with altered levels of inflammatory mediators. (20658182)
2011
21
The catabolic role of toll-like receptor 2 (TLR-2) mediated by the NF-I_B pathway in septic arthritis. (20740673)
2011
22
Trochanteroplasty to treat sequelae of septic arthritis of the hip in infancy. Case series and review of the literature. (22183446)
2011
23
The use of CRP within a clinical prediction algorithm for the differentiation of septic arthritis and transient synovitis in children. (22058311)
2011
24
Return to sports activity after postoperative septic arthritis in ACL reconstruction. (20959698)
2010
25
Colovesical, coloenteric, colocutaneous fistula, and hip septic arthritis secondary to sigmoid diverticulitis. (20012298)
2010
26
Septic sacroiliitis: an uncommon septic arthritis. (20149323)
2009
27
Post-partum septic arthritis of the knee: a case report. (19829917)
2009
28
Disseminating septic arthritis following hip hemiarthroplasty. (19637515)
2009
29
Bacteroides fragilis: a case study of bacteremia and septic arthritis. (19827405)
2009
30
Polyarticular septic arthritis with bilateral psoas abscesses following acupuncture. (19502468)
2009
31
Chronic lymphoedema complicated by septic arthritis of the hip. (19298275)
2009
32
Results of arthroscopic adhesiolysis and manipulation in the stiff knee secondary to septic arthritis and inflammatory arthritis. (19148646)
2009
33
Optimal management of sternoclavicular septic arthritis. (19404199)
2009
34
Analysis of factors influencing prognosis in foals with septic arthritis. (21851707)
2008
35
Septic arthritis in haemodialysis patients: a seven-year multi-centre review. (18453661)
2008
36
Septic arthritis: clinical audits would help optimise the management. (18795395)
2008
37
Evidence-based emergency medicine/rational clinical examination abstract. Septic arthritis in emergency department patients with joint pain: searching for the optimal diagnostic tool. (18294730)
2008
38
Procalcitonin, C-reactive protein, and complement-3a assays in synovial fluid for diagnosing septic arthritis: preliminary results. (18178503)
2008
39
Melioidosis--an unusual cause of septic arthritis. (18506568)
2008
40
Management of septic arthritis: a systematic review. (18508984)
2008
41
Septic arthritis of the distal interphalangeal joint in cattle: comparison of digital amputation and joint resection by solar approach. (17547598)
2007
42
Familial Mediterranean fever mimicking septic arthritis. (15700115)
2005
43
Rat-bite fever presenting with rash and septic arthritis. (16858964)
2005
44
Assessment of the test characteristics of C-reactive protein for septic arthritis in children. (12724603)
2003
45
Mycobacterium kansasii septic arthritis: French retrospective study of 5 years and review. (10585795)
1999
46
Poststreptococcal reactive arthritis mimicking acute septic arthritis: a hospital-based study. (7593582)
1995
47
Deep venous thrombosis in intravenous cocaine abuse mimicking septic arthritis of the shoulder. (1990471)
1991
48
Treatment of septic arthritis due to Mycobacterium kansasii. (3919820)
1985
49
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
50
Septic arthritis of the hip joint secondary to umbilical artery catheterization associated with transient femoral and sciatic neuropathy. (4365200)
1974

Variations for Septic Arthritis

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Expression for genes affiliated with Septic Arthritis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Septic Arthritis

Search GEO for disease gene expression data for Septic Arthritis.

Pathways for genes affiliated with Septic Arthritis

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Sources:
50PathCards, 54R&D Systems, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters, 53QIAGEN
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Pathways related to Septic Arthritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CXCL11, CXCR3
29.5CXCR3, CXCL11
3
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.2CXCL11, TLR2
4
Show member pathways
9.1TLR2, DEFB4A
5
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7CXCL11, TLR2, DEFB4A
6
Show member pathways
8.7CXCR3, CXCL11, TLR2

Compounds for genes affiliated with Septic Arthritis

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Septic Arthritis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1tarc459.7CXCR3, CXCL11
2hbd2459.4TLR2, DEFB4A
3hcec459.4DEFB4A, TLR2
4lipoteichoic acid459.4DEFB4A, TLR2
5il 10459.4CXCR3, TLR2
6anti-fungal459.4DEFB4A, TLR2
7peptidoglycan45 2910.3TLR2, DEFB4A
8sp 60012545 6110.1DEFB4A, TLR2
9tacrolimus45 51 1111.1CXCR3, TLR2
10progesterone45 29 61 24 1113.1DEFB4A, CXCL11, CXCR3
11mannose459.0TLR2, DEFB4A
12ccl345 2910.0CXCR3, CXCL11, TLR2
13ccl445 2910.0TLR2, CXCL11, CXCR3
14flagellin45 2910.0CXCR3, TLR2, DEFB4A
15histamine45 29 2410.9CXCR3, TLR2, DEFB4A
16pd 98,059458.9CXCR3, TLR2, DEFB4A
17heparan sulfate45 249.8CXCR3, TLR2
18arginine458.7CXCR3, CXCL11, TLR2
19rantes458.5DEFB4A, TLR2, CXCL11, CXCR3
20dexamethasone45 51 29 1111.5CXCR3, CXCL11, TLR2, DEFB4A
21endotoxin458.3MEFV, CXCR3, TLR2, DEFB4A
22calcium45 51 24 1111.3CXCR3, CXCL11, TLR2, DEFB4A
23tyrosine458.2MEFV, CXCR3, TLR2, DEFB4A

GO Terms for genes affiliated with Septic Arthritis

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16Gene Ontology
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Cellular components related to Septic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1CXCR3, TLR2

Biological processes related to Septic Arthritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:0308169.7CXCR3, CXCL11
2T cell chemotaxisGO:0108189.6CXCL11, CXCR3
3positive regulation of cAMP-mediated signalingGO:0439509.5CXCL11, CXCR3
4positive regulation of release of sequestered calcium ion into cytosolGO:0512819.4CXCR3, CXCL11
5chemotaxisGO:0069359.1CXCR3, DEFB4A, CXCL11
6negative regulation of interleukin-12 productionGO:0326959.1MEFV, TLR2
7innate immune responseGO:0450878.5MEFV, TLR2, DEFB4A
8immune responseGO:0069558.4CXCL11, TLR2, DEFB4A
9inflammatory responseGO:0069548.3CXCL11, MEFV, CXCR3, TLR2

Molecular functions related to Septic Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.1CXCR3, TLR2

Products for genes affiliated with Septic Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Septic Arthritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet