MCID: SPT013
MIFTS: 62

Septic Shock malady

Summaries for Septic Shock

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Septic shock is a medical condition as a result of severe infection and sepsis, though the microbe may... more...

MalaCards: Septic Shock, also known as shock septic, is related to sepsis and adult respiratory distress syndrome. An important gene associated with Septic Shock is TNF (tumor necrosis factor), and among its related pathways are Pertussis and Development PDGF signaling via STATs and NF-kB. The drugs dexamethasone and dexamethasone acetate and the compounds vegf and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are immune system and mortality/aging.

Aliases & Classifications for Septic Shock

Sources:
47OMIM, 45Novoseek, 61UMLS, 25ICD10
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Related Diseases for Septic Shock

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Septic Shock via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 326)
idRelated DiseaseScoreTop Affiliating Genes
1sepsis31.8CFP, MIF
2adult respiratory distress syndrome30.8TNF, MIF, CD14, IL8, IL6, NOS2
3acute myocardial infarction30.4SERPINC1, PTX3, CD14, MIF, ANGPT2, NPPB
4tuberculosis30.4MIF, TNF, POMC, TREM1, IL10
5purpura fulminans30.4F5, SERPINC1
6acute pancreatitis30.3IL6, CASP1, MIF, CD14, IL10, IL8
7arthritis30.3IL6, IL8, TNF
8meningococcemia30.3SERPINC1, F5
9toxic shock syndrome30.3TNF
10phaeochromocytoma30.3ADM
11acute leukemia30.3CASP1, CD14
12insulin resistance30.0SERPINA6, IL6, MIF, TNF
13cystic fibrosis30.0IL8
14hepatitis c30.0IL10
15protein c deficiency30.0SERPINC1, CFP, F5
16paracoccidioidomycosis30.0IL10
17acute adrenal insufficiency30.0POMC
18agammaglobulinemia30.0CFP
19hypoaldosteronism30.0POMC
20adult syndrome10.5
21n syndrome10.5
22bacteremia10.5
23acute pyelonephritis10.4
24cardiogenic shock10.4
25severe acute respiratory syndrome10.3
26melioidosis10.3
27necrotizing fasciitis10.3
28critical illness polyneuropathy10.3
29metabolic acidosis10.3
30shigellosis10.3
31meningococcal infection10.3
32brain injury10.3
33hemophagocytic lymphohistiocytosis10.2
34coccidioidomycosis10.2
35meningoencephalitis10.2
36thrombotic thrombocytopenic purpura10.2
37appendicitis10.2
38waterhouse-friderichsen syndrome10.2
39babesiosis10.2
40pyoderma gangrenosum10.2
41polycystic kidney disease10.2
42ecthyma10.2
43septic arthritis10.2
44scrub typhus10.2
45autosomal dominant disease10.2
46typhus10.2
47micro syndrome10.2
48polycystic kidney disease, autosomal dominant10.2
49klebsiella10.2
50properdin deficiency10.2

Graphical network of the top 20 diseases related to Septic Shock:



Diseases related to septic shock

Clinical Features for Septic Shock

Drugs & Therapeutics for Septic Shock

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Septic Shock

Anatomical Context for Septic Shock

Sources:
33MalaCards
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MalaCards organs/tissues related to Septic Shock:

33
Skin, Liver, Brain, Kidney, Lung, Bone marrow, Whole blood, Heart, Skeletal muscle, Thyroid, Salivary gland, Adrenal gland, Placenta, Prostate, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Cardiac myocytes, Pituitary

Animal Models for Septic Shock or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Septic Shock

Sources:
51PubMed
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Articles related to Septic Shock:

(show top 50)    (show all 1079)
idTitleAuthorsYear
1
Catheter-related septic shock by Micrococcus in an autologous hematopoietic stem cell transplantation recipient. (24388476)
2014
2
Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media. (23379624)
2013
3
Postoperative Polymyxin B Hemoperfusion and Mortality in Patients With Abdominal Septic Shock: A Propensity-Matched Analysis. (24365858)
2013
4
Prescribing patterns for corticosteroids in septic shock: translating guidelines to bedside practice. (24060775)
2013
5
Septic shock: the initial moments and beyond. (23456468)
2013
6
Early recognition of septic shock in children. (23873258)
2013
7
Timing of appropriate antibiotics in patients with septic shock: a retrospective cohort study. (23911021)
2013
8
Counterpoint: Should antipyretic therapy be given routinely to febrile patients in septic shock? No. (24081340)
2013
9
Severe sepsis and septic shock in patients with pre-existing non-cardiac pulmonary hypertension: contemporary management and outcomes. (23931041)
2013
10
Neurohypophyseal response to fluid resuscitation with hypertonic saline during septic shock in rats. (22903979)
2013
11
The hemodynamics of septic shock: a historical perspective. (23506492)
2013
12
Plasma l-citrulline concentrations and its relationship with inflammation at the onset of septic shock: A pilot study. (24360391)
2013
13
Vancomycin pharmacodynamics and survival in patients with methicillin-resistant Staphylococcus aureus-associated septic shock. (23312606)
2013
14
Severe sepsis and septic shock. (24256390)
2013
15
Migrating Ingested Foreign Body of the Upper Aerodigestive Tract with Resultant Septic Shock: Case report and literature review. (24273677)
2013
16
Decompensated septic shock in the setting of megace-induced severe adrenal suppression in an otherwise healthy pediatric patient: a case report. (22863821)
2012
17
Staphylococcus aureus pericardial abscess presenting as severe sepsis and septic shock after acupuncture therapy. (22870086)
2012
18
The role of complement system in septic shock. (23049598)
2012
19
Time to effective antibiotic administration in adult patients with septic shock: a descriptive analysis. (22537476)
2012
20
Procalcitonin as a prognostic biomarker of severe sepsis and septic shock. (23348640)
2012
21
Predictors of septic shock in patients with methicillin-resistant Staphylococcus aureus bacteremia. (22497963)
2012
22
Recent advances in perioperative anesthetic management update in the perioperative support of patients with septic shock and the effect on outcomes. (22762469)
2012
23
Hemophagocytic lymphohistiocytosis: a potentially underrecognized association with systemic inflammatory response syndrome, severe sepsis, and septic shock in adults. (21737492)
2011
24
Dynamic change of procalcitonin, rather than concentration itself, is predictive of survival in septic shock patients when beyond 10 ng/mL. (21937947)
2011
25
The septic shock-associated IL-10 -1082 A > G polymorphism mediates allele-specific transcription via poly(ADP-Ribose) polymerase 1 in macrophages engulfing apoptotic cells. (20181890)
2010
26
Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. (20181046)
2010
27
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. (19062078)
2009
28
Mannose-binding lectin is a critical factor in systemic complement activation during meningococcal septic shock. (19793001)
2009
29
Selenoprotein P, rather than glutathione peroxidase, as a potential marker of septic shock and related syndromes. (19779296)
2009
30
Angiopoietin balance in septic shock patients treated by direct hemoperfusion with polymyxin b-immobilized fiber. (19954476)
2009
31
Streptococcal toxic shock syndrome presenting as septic knee arthritis in a 5-year-old child. (18157057)
2008
32
Basal serum cortisol levels are not predictive of response to corticotropin but have prognostic significance in patients with septic shock. (17596656)
2007
33
The new aspects of treatment of severe sepsis and septic shock]. (16687897)
2006
34
Potential role of poly(adenosine 5'-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock. (16484919)
2006
35
Glucocorticoids in the treatment of severe sepsis and septic shock. (16175031)
2005
36
Time course of endothelial damage in septic shock: prediction of outcome. (16137344)
2005
37
Changes in the interleukin-6/soluble interleukin-6 receptor axis in meningococcal septic shock. (16096463)
2005
38
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. (15090974)
2004
39
Multifocal necrotizing leukoencephalopathy in septic shock. (12394971)
2002
40
Pathogenesis of septic shock: implications for prevention and treatment. (11936363)
2001
41
Indocyanine green elimination rate detects hepatocellular dysfunction early in septic shock and correlates with survival. (11395594)
2001
42
Porins from Salmonella typhimurium accelerate human blood coagulation in vitro by selective stimulation of thrombin activity: implications in septic shock DIC pathogenesis. (11581572)
2001
43
A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. (10697064)
2000
44
Changes in plasma erythropoietin and interleukin-6 concentrations in patients with septic shock after hemoperfusion with polymyxin B-immobilized fiber. (9885879)
1998
45
Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. (9142022)
1997
46
Tumor necrosis factor in septic shock and multiple system trauma. (9366750)
1997
47
Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients. (8704245)
1996
48
Protection against septic shock in mice with SJC13, an azaindolidine derivative that is a cell adhesion molecule inhibitor. (8891755)
1996
49
High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock. (7798670)
1995
50
Therapeutic trial of reconstituted human high-density lipoprotein in a canine model of gram-negative septic shock. (7853173)
1995

Genetic Variations for Septic Shock

Expression for genes affiliated with Septic Shock

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Septic Shock

Search GEO for disease gene expression data for Septic Shock.

Pathways for genes affiliated with Septic Shock

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 53R&D Systems, 54Reactome
See all sources

Pathways related to Septic Shock according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9NOS2, IL6, IL8, IL10, CD14, TNF
2
Development PDGF signaling via STATs and NF-kB
Hide members
10.8TNF, ANGPT2, CD14, IL10, IL6, NOS2
3
Hide members
10.8TNF, MIF, CD14, IL8, IL6, NOS2
4
Hide members
10.8TNF, CD14, IL10, IL8, IL6, NOS2
510.8AVP, IL6, IL8, IL10, TNF
6
Hide members
10.8CASP1, TNF, IL8, IL6, CFP
710.8TNF, CD14, IL10, IL6, NOS2
8
Hide members
10.8CASP1, TNF, CD14, IL8, IL6
910.8CASP1, TNF, CD14, IL8, IL6
1010.8TNF, MIF, IL8, IL6, NOS2
11
Immune response Bacterial infections in normal airways
10.8TNF, CD14, IL8, IL6, NOS2
1210.8NOS2, IL6, IL8, CD14, CASP1
13
Hide members
10.7IL6, IL8, TNF, CASP1
1410.7TNF, CD14, IL10, IL6
1510.7IL6, IL8, IL10, TNF
1610.7NOS2, IL8, IL10, CD14
1710.6TNF, IL10, IL6
18
Hide members
10.6IL6, IL10, TNF
1910.6IL6, IL10, TNF
2010.6NOS2, IL6, TNF
2110.6TNF, CD14, IL6
22
Hide members
10.6CASP1, ANGPT2, CD14
2310.6POMC, IL8, IL6
2410.6IL8, CD14, TNF
2510.6TNF, DIO3, IL6
26
Cytokine production by Th17 cells in CF (Mouse model)
10.6CD14, IL8, IL6
2710.6IL6, IL8, CD14
2810.6CD14, MIF
29
Hide members
10.5ANGPT2
3010.5IL8

Compounds for genes affiliated with Septic Shock

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Septic Shock according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1vegf4511.7CASP1, TNF, NPPB, F5, ANGPT2, POMC
2nitric oxide45 11 2413.6ANGPT2, NPPB, MIF, IL10, CASP1, F5
3cysteine4511.6IL8, SERPINA6, CASP1, ADM, CFP, AVP
4dexamethasone45 50 29 1114.4CASP1, NPPB, DIO3, ANGPT2, POMC, CD14
5alanine4511.4DIO3, AVP, ADM, F5, POMC, MIF
6lactate4511.4IL8, CD14, MIF, F5, CASP1, TNF
7creatinine4511.4CASP1, NPPB, F5, ANGPT2, POMC, AVP
8sb 20358045 6012.3CASP1, NOS2, IL6, IL8, IL10, MIF
9histamine45 29 2413.3ADM, TNF, NPPB, CD14, IL10, IL8
10steroid4511.3NPPB, F5, ANGPT2, POMC, ADM, SERPINA6
11actinomycin d4511.3ADM, CASP1, PTX3, NOS2, TNF, NPPB
12arginine4511.3CD14, SERPINA6, ADM, POMC, F5, SERPINC1
13prostacyclin4511.3F5, IL10, ADM, SERPINC1, NOS2, NPPB
14peptidoglycan45 2912.2IL10, CASP1, TNF, CD14, IL6, IL8
15serine4511.2POMC, AVP, IL8, MIF, TNF, CASP1
16taurine chloramine4511.2IL8, TNF, IL6, NOS2, F5
17glucose4511.2NPPB, ADM, AVP, SERPINA6, CD14, POMC
18cyclosporin a45 29 6013.2CD14, CASP1, NPPB, ANGPT2, ADM
19homocysteine45 2412.1NPPB, MIF, CD14, SERPINC1, F5, ADM
20polymyxin b4511.1TNF, IL6, IL10, IL8, CD14
21hydrocortisone45 2 60 1114.1ADM, SERPINA6, POMC, IL8
22triptolide4511.1NOS2, CD14, TNF, IL8, IL6
23prednisolone45 29 1113.1SERPINA6, CD14, POMC, NPPB
24lipoteichoic acid4511.1IL8, TNF, CD14, IL10, IL6
258-isoprostane4511.1IL6, TNF, IL8, IL10, NPPB
26polyinosinic-polycytidylic acid4511.1NOS2, IL8, IL6, TNF, IL10
27herbimycin a45 6012.1IL6, NOS2, IL8, CD14, MIF, TNF
28aprotinin45 1112.1NPPB, SERPINC1, IL8, F5
29endotoxin4511.1ADM, F5, CASP1
30ly2940024511.1ANGPT2, TNF, IL10, NOS2, IL6, CD14
31pentoxifylline45 1112.1CASP1, CD14, NPPB
32gabexate mesilate4511.0F5, SERPINC1
33ccl345 2912.0PTX3, IL6, TNF, IL10, IL8
34gm-csf45 2912.0TNF, IL10, CD14
35mip 1alpha4511.0TNF, IL10, IL8, IL6
36neopterin4511.0IL6, IL8, CD14, TNF, IL10
37testosterone45 60 11 2414.0NPPB, CASP1, POMC, IL6, SERPINC1, F5
38pge24511.0POMC
39superoxide45 2412.0CFP, TNF, CASP1
4015-deoxy-delta-12,14-prostaglandin j24511.0IL6, NOS2, IL10, TNF, IL8
41ulinastatin4511.0SERPINC1
42estrogen4510.9NPPB
43acth4510.9POMC, MIF, IL6, ADM, AVP, SERPINA6
44norepinephrine45 11 2412.9POMC, ADM, AVP
45il-124510.9IL8, IL10, TNF, IL6
46h2o24510.8CASP1, ANGPT2, MIF
47imiquimod45 29 60 1113.7IL6, IL8, IL10, TNF
48rantes4510.6TNF, CD14, IL6
49tpck4510.6CASP1, TNF, IL8, IL6
50corticosterone45 60 2412.5ADM, MIF, IL10, POMC, SERPINA6

GO Terms for genes affiliated with Septic Shock

Sources:
16Gene Ontology
See all sources

Cellular components related to Septic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.3SERPINA6, SERPINC1, CFP, AVP, IL6, IL8
2extracellular regionGO:00557611.1ADM, CASP1, TNF, SERPINC1, PTX3, CFP

Biological processes related to Septic Shock according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.3PTX3, TNF, MIF, CD14, IL10, IL8
2response to hypoxiaGO:00166611.1CASP1, TNF, ANGPT2, NOS2, ADM
3positive regulation of cytokine secretionGO:05071511.1TNF, MIF, CD14, IL10
4positive regulation of peptidyl-serine phosphorylationGO:03313811.0AVP, IL6, MIF, TNF
5response to glucocorticoid stimulusGO:05138411.0ADM, IL6, IL10, TNF
6cellular response to lipopolysaccharideGO:07122211.0CD14, IL10, IL8, NOS2
7response to activityGO:01482311.0IL10, ANGPT2, TNF
8positive regulation of nitric oxide biosynthetic processGO:04542910.9TNF, IL6, PTX3
9humoral immune responseGO:00695910.9TNF, TREM1, IL6
10blood coagulationGO:00759610.9SERPINC1, NOS2, TREM1, ANGPT2, F5
11response to mechanical stimulusGO:00961210.9IL6, ANGPT2, TNF
12receptor biosynthetic processGO:03280010.9IL10, TNF
13response to insulin stimulusGO:03286810.9IL10, IL6, ADM
14positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.9MIF, TNF
15signal transductionGO:00716510.8ADM, AVP, IL8, POMC, ANGPT2, CASP1
16epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.8TNF, IL6
17negative regulation of lipid storageGO:01088810.8TNF, IL6
18negative regulation of gene expressionGO:01062910.8TNF, MIF, NOS2
19negative regulation of cytokine secretion involved in immune responseGO:00274010.8IL10
20branching involved in labyrinthine layer morphogenesisGO:06067010.7ADM, IL10
21cell-cell signalingGO:00726710.6POMC, IL10, AVP, ADM
22response to molecule of bacterial originGO:00223710.6IL8, IL10
23positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.3TNF, IL10, IL6

Molecular functions related to Septic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.8ADM, NOS2, AVP, MIF, POMC, ANGPT2
2hormone activityGO:00517910.6ADM, POMC, NPPB
3cytokine activityGO:00512510.4TNF, MIF, IL10, IL6

Products for genes affiliated with Septic Shock

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Sources for Septic Shock

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet