MCID: SPT013
MIFTS: 48

Septic Shock malady

Summaries for Septic Shock

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3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Sepsis is an illness that affects all parts of the body that can happen in response to an infection and can quickly become life-threatening.

MalaCards: Septic Shock, also known as shock septic, is related to pneumonia and disseminated intravascular coagulation. An important gene associated with Septic Shock is TNF (tumor necrosis factor), and among its related pathways are Pertussis and Development PDGF signaling via STATs and NF-kB. The drugs dexamethasone and dexamethasone acetate and the compounds vegf and nitric oxide have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and mortality/aging.

Wikipedia:63 Septic shock is a medical condition as a result of severe infection and sepsis, though the microbe may... more...

Aliases & Classifications for Septic Shock

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Sources:
46OMIM, 60UMLS, 44Novoseek, 25ICD10
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Related Diseases for Septic Shock

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17GeneCards, 18GeneDecks
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Diseases related to Septic Shock via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.0IL8, IL10, ADM, TNF, TREM1, IL6
2disseminated intravascular coagulation30.8CD14, SERPINC1, F5
3purpura30.8SERPINC1
4adult respiratory distress syndrome30.7TNF, MIF, CD14, IL8, IL6, NOS2
5leukemia30.5CASP1, TNF, ANGPT2, IL6, CD14
6peritonitis30.5IL6, CD14, TNF
7myocardial infarction30.4CASP1, NPPB, F5, CD14, ADM, SERPINC1
8acute myocardial infarction30.4SERPINC1, PTX3, CD14, MIF, ANGPT2, NPPB
9tuberculosis30.4MIF, TNF, POMC, TREM1, IL10
10respiratory failure30.4TNF, SERPINC1, IL6
11pancreatitis30.4IL10, IL6, CASP1
12rheumatoid arthritis30.2IL10, IL8, IL6, CD14, NOS2, PTX3
13acute pancreatitis30.2IL6, CASP1, MIF, CD14, IL10, IL8
14hypertension30.2AVP, ADM, POMC, F5, NPPB
15meningitis30.2IL8, IL6, AVP, CFP
16hyperglycemia30.2NOS2, POMC
17arthritis30.2IL6, IL8, TNF
18thyroiditis30.2POMC
19protein c deficiency30.2SERPINC1, CFP, F5
20toxic shock syndrome30.2TNF
21influenza30.2CASP1
22down syndrome30.2CASP1
23sepsis30.2CFP, MIF
24phaeochromocytoma30.2ADM
25acute leukemia30.2CASP1, CD14
26ischemia30.0ANGPT2, NPPB, CD14, NOS2, ADM, CASP1
27hypothyroidism30.0SERPINA6, AVP, POMC, DIO3
28obesity30.0TNF, POMC, IL6, SERPINA6
29gastritis30.0IL8, MIF, NOS2
30eosinophilia30.0IL8, CD14, IL10
31myocarditis30.0NOS2, NPPB
32encephalomyelitis30.0IL10, TNF, NOS2
33cystic fibrosis30.0IL8
34myopathy30.0POMC
35paracoccidioidomycosis30.0IL10
36periodontitis30.0IL8
37myositis30.0CASP1
38agammaglobulinemia30.0CFP
39antithrombin iii deficiency30.0SERPINC1, F5
40adult syndrome10.5
41pyelonephritis10.4
42acute pyelonephritis10.4
43fasciitis10.4
44severe acute respiratory syndrome10.3
45melioidosis10.3
46necrotizing fasciitis10.3
47critical illness polyneuropathy10.3
48metabolic acidosis10.3
49shigellosis10.3
50hepatitis10.3

Graphical network of the top 20 diseases related to Septic Shock:



Diseases related to septic shock

Clinical Features for Septic Shock

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Drugs & Therapeutics for Septic Shock

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Septic Shock

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Anatomical Context for Septic Shock

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Animal Models for Septic Shock or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Septic Shock:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.6ADM, CASP1, TNF, ANGPT2, TREM1, POMC
2MP:001076811.5TREM1, ANGPT2, F5, DIO3, TNF, CASP1
3MP:000537611.3CASP1, DIO3, F5, TREM1, POMC, CD14
4MP:000537011.2TNF, F5, POMC, IL10, IL6, NOS2
5MP:000538511.1CASP1, NPPB, ANGPT2, POMC, IL10, CFP
6MP:000200611.1CASP1, TNF, TREM1, POMC, MIF, IL10
7MP:000539711.0CASP1, TNF, TREM1, POMC, MIF, IL10
8MP:000538411.0TREM1, DIO3, TNF, CASP1, POMC, MIF
9MP:000538611.0F5, POMC, IL10, IL6, AVP, NOS2
10MP:001077110.8CASP1, ANGPT2, POMC, IL6
11MP:000536710.8POMC, AVP, SERPINA6, ADM
12MP:000538810.3IL6, PTX3

Publications for Septic Shock

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Genetic Variations for Septic Shock

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Expression for genes affiliated with Septic Shock

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Septic Shock

Search GEO for disease gene expression data for Septic Shock.

Pathways for genes affiliated with Septic Shock

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Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 52R&D Systems, 53Reactome
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Pathways related to Septic Shock according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9NOS2, IL6, IL8, IL10, CD14, TNF
2
Development PDGF signaling via STATs and NF-kB
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10.8TNF, ANGPT2, CD14, IL10, IL6, NOS2
3
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10.8TNF, MIF, CD14, IL8, IL6, NOS2
4
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10.8TNF, CD14, IL10, IL8, IL6, NOS2
510.8AVP, IL6, IL8, IL10, TNF
6
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10.8CASP1, TNF, IL8, IL6, CFP
710.8TNF, CD14, IL10, IL6, NOS2
8
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10.8CASP1, TNF, CD14, IL8, IL6
910.8CASP1, TNF, CD14, IL8, IL6
1010.8TNF, MIF, IL8, IL6, NOS2
11
Immune response Bacterial infections in normal airways
10.8TNF, CD14, IL8, IL6, NOS2
1210.8NOS2, IL6, IL8, CD14, CASP1
13
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10.7IL6, IL8, TNF, CASP1
1410.7TNF, CD14, IL10, IL6
1510.7IL6, IL8, IL10, TNF
1610.7NOS2, IL8, IL10, CD14
1710.6TNF, IL10, IL6
18
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10.6IL6, IL10, TNF
1910.6IL6, IL10, TNF
2010.6NOS2, IL6, TNF
2110.6TNF, CD14, IL6
22
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10.6CASP1, ANGPT2, CD14
2310.6POMC, IL8, IL6
2410.6IL8, CD14, TNF
2510.6TNF, DIO3, IL6
26
Cytokine production by Th17 cells in CF (Mouse model)
10.6CD14, IL8, IL6
2710.6IL6, IL8, CD14
2810.6CD14, MIF
29
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10.5ANGPT2
3010.5IL8

Compounds for genes affiliated with Septic Shock

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Septic Shock according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1vegf4411.7CASP1, TNF, NPPB, F5, ANGPT2, POMC
2nitric oxide44 11 2413.6ANGPT2, NPPB, MIF, IL10, CASP1, F5
3cysteine4411.6IL8, SERPINA6, CASP1, ADM, CFP, AVP
4dexamethasone44 49 28 1114.4CASP1, NPPB, DIO3, ANGPT2, POMC, CD14
5alanine4411.4DIO3, AVP, ADM, F5, POMC, MIF
6lactate4411.4IL8, CD14, MIF, F5, CASP1, TNF
7creatinine4411.4CASP1, NPPB, F5, ANGPT2, POMC, AVP
8sb 20358044 5912.3CASP1, NOS2, IL6, IL8, IL10, MIF
9histamine44 28 2413.3ADM, TNF, NPPB, CD14, IL10, IL8
10steroid4411.3NPPB, F5, ANGPT2, POMC, ADM, SERPINA6
11actinomycin d4411.3ADM, CASP1, PTX3, NOS2, TNF, NPPB
12arginine4411.3CD14, SERPINA6, ADM, POMC, F5, SERPINC1
13prostacyclin4411.3F5, IL10, ADM, SERPINC1, NOS2, NPPB
14peptidoglycan44 2812.2IL10, CASP1, TNF, CD14, IL6, IL8
15serine4411.2POMC, AVP, IL8, MIF, TNF, CASP1
16taurine chloramine4411.2IL8, TNF, IL6, NOS2, F5
17glucose4411.2NPPB, ADM, AVP, SERPINA6, CD14, POMC
18cyclosporin a44 28 5913.2CD14, CASP1, NPPB, ANGPT2, ADM
19homocysteine44 2412.1NPPB, MIF, CD14, SERPINC1, F5, ADM
20polymyxin b4411.1TNF, IL6, IL10, IL8, CD14
21hydrocortisone44 2 59 1114.1ADM, SERPINA6, POMC, IL8
22triptolide4411.1NOS2, CD14, TNF, IL8, IL6
23prednisolone44 28 1113.1SERPINA6, CD14, POMC, NPPB
24lipoteichoic acid4411.1IL8, TNF, CD14, IL10, IL6
258-isoprostane4411.1IL6, TNF, IL8, IL10, NPPB
26polyinosinic-polycytidylic acid4411.1NOS2, IL8, IL6, TNF, IL10
27herbimycin a44 5912.1IL6, NOS2, IL8, CD14, MIF, TNF
28aprotinin44 1112.1NPPB, SERPINC1, IL8, F5
29endotoxin4411.1ADM, F5, CASP1
30ly2940024411.1ANGPT2, TNF, IL10, NOS2, IL6, CD14
31pentoxifylline44 1112.1CASP1, CD14, NPPB
32gabexate mesilate4411.0F5, SERPINC1
33ccl344 2812.0PTX3, IL6, TNF, IL10, IL8
34gm-csf44 2812.0TNF, IL10, CD14
35mip 1alpha4411.0TNF, IL10, IL8, IL6
36neopterin4411.0IL6, IL8, CD14, TNF, IL10
37testosterone44 59 11 2414.0NPPB, CASP1, POMC, IL6, SERPINC1, F5
38pge24411.0POMC
39superoxide44 2412.0CFP, TNF, CASP1
4015-deoxy-delta-12,14-prostaglandin j24411.0IL6, NOS2, IL10, TNF, IL8
41ulinastatin4411.0SERPINC1
42estrogen4410.9NPPB
43acth4410.9POMC, MIF, IL6, ADM, AVP, SERPINA6
44norepinephrine44 11 2412.9POMC, ADM, AVP
45il-124410.9IL8, IL10, TNF, IL6
46h2o24410.8CASP1, ANGPT2, MIF
47imiquimod44 28 59 1113.7IL6, IL8, IL10, TNF
48rantes4410.6TNF, CD14, IL6
49tpck4410.6CASP1, TNF, IL8, IL6
50corticosterone44 59 2412.5ADM, MIF, IL10, POMC, SERPINA6

GO Terms for genes affiliated with Septic Shock

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16Gene Ontology
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Cellular components related to Septic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.3SERPINA6, SERPINC1, CFP, AVP, IL6, IL8
2extracellular regionGO:00557611.1ADM, CASP1, TNF, SERPINC1, PTX3, CFP

Biological processes related to Septic Shock according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.3PTX3, TNF, MIF, CD14, IL10, IL8
2response to hypoxiaGO:00166611.1CASP1, TNF, ANGPT2, NOS2, ADM
3positive regulation of cytokine secretionGO:05071511.1TNF, MIF, CD14, IL10
4positive regulation of peptidyl-serine phosphorylationGO:03313811.0AVP, IL6, MIF, TNF
5response to glucocorticoid stimulusGO:05138411.0ADM, IL6, IL10, TNF
6cellular response to lipopolysaccharideGO:07122211.0CD14, IL10, IL8, NOS2
7response to activityGO:01482311.0IL10, ANGPT2, TNF
8positive regulation of nitric oxide biosynthetic processGO:04542910.9TNF, IL6, PTX3
9humoral immune responseGO:00695910.9TNF, TREM1, IL6
10blood coagulationGO:00759610.9SERPINC1, NOS2, TREM1, ANGPT2, F5
11response to mechanical stimulusGO:00961210.9IL6, ANGPT2, TNF
12receptor biosynthetic processGO:03280010.9IL10, TNF
13response to insulin stimulusGO:03286810.9IL10, IL6, ADM
14positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.9MIF, TNF
15signal transductionGO:00716510.8ADM, AVP, IL8, POMC, ANGPT2, CASP1
16epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.8TNF, IL6
17negative regulation of lipid storageGO:01088810.8TNF, IL6
18negative regulation of gene expressionGO:01062910.8TNF, MIF, NOS2
19negative regulation of cytokine secretion involved in immune responseGO:00274010.8IL10
20branching involved in labyrinthine layer morphogenesisGO:06067010.7ADM, IL10
21cell-cell signalingGO:00726710.6POMC, IL10, AVP, ADM
22response to molecule of bacterial originGO:00223710.6IL8, IL10
23positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.3TNF, IL10, IL6

Molecular functions related to Septic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.8ADM, NOS2, AVP, MIF, POMC, ANGPT2
2hormone activityGO:00517910.6ADM, POMC, NPPB
3cytokine activityGO:00512510.4TNF, MIF, IL10, IL6

Products for genes affiliated with Septic Shock

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Sources for Septic Shock

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet