MCID: SPT013
MIFTS: 60

Septic Shock malady

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Summaries for Septic Shock

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65Wikipedia, 33MalaCards
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Wikipedia:65 Septic shock is a medical condition as a result of severe infection and sepsis, though the microbe may... more...

MalaCards: Septic Shock, also known as shock septic, is related to sepsis and pneumonia. An important gene associated with Septic Shock is TNF (tumor necrosis factor), and among its related pathways are Cellular roles of Anthrax toxin and Immune response MIF mediated glucocorticoid regulation. The drugs dexamethasone and dexamethasone acetate and the compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include monocytes, kidney and testes, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Septic Shock

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47OMIM, 62UMLS, 45Novoseek, 25ICD10
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Related Diseases for Septic Shock

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17GeneCards, 18GeneDecks
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Diseases related to Septic Shock via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1sepsis32.0CFP, MIF
2pneumonia31.0AVP, TNF, IL10, TREM1
3adult respiratory distress syndrome30.8TNF, MIF, F5
4purpura fulminans30.5SERPINC1, F5
5meningitis30.4CFP, AVP
6hypertension30.4F5, POMC, AVP
7meningococcemia30.4F5, SERPINC1
8tuberculosis30.4TNF, POMC, MIF, IL10, TREM1
9acute myocardial infarction30.3MIF, ANGPT2, SERPINC1
10arthritis30.2TNF, POMC, MIF, IL10, CASP1
11hypothyroidism30.2AVP, POMC, DIO3
12rheumatoid arthritis30.2TNF, SAA2, ANGPT2, MIF, IL10, CASP1
13coronary thrombosis30.2SERPINC1
14protein c deficiency30.1CFP, SERPINC1, F5
15protein s deficiency30.1SERPINC1, F5
16antiphospholipid syndrome30.0F5, SERPINC1
17respiratory failure30.0SERPINC1, TNF
18disseminated intravascular coagulation10.6
19purpura10.5
20blindness10.5
21endotheliitis10.5
22pyelonephritis10.5
23bacteremia10.5
24fasciitis10.4
25acute pyelonephritis10.3
26leukemia10.3
27cardiogenic shock10.3
28melioidosis10.3
29necrotizing fasciitis10.3
30shigellosis10.3
31metabolic acidosis10.3
32critical illness polyneuropathy10.3
33hepatitis10.3
34kidney disease10.3
35myocardial infarction10.3
36pancreatitis10.3
37peritonitis10.3
38polyneuropathy10.3
39brain injury10.3
40thrombotic thrombocytopenic purpura10.2
41neuronitis10.2
42meningoencephalitis10.2
43appendicitis10.2
44babesiosis10.2
45pyoderma gangrenosum10.2
46polycystic kidney disease10.2
47ecthyma10.2
48hemophagocytic lymphohistiocytosis10.2
49coccidioidomycosis10.2
50phaeochromocytoma10.2

Graphical network of the top 20 diseases related to Septic Shock:



Diseases related to septic shock

Symptoms for Septic Shock

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Drugs & Therapeutics for Septic Shock

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Septic Shock

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Anatomical Context for Septic Shock

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33MalaCards
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MalaCards organs/tissues related to Septic Shock:

33
Monocytes, Kidney, Testes, Heart, Brain, Endothelial, Liver, Lung, Myeloid, T cells, Thyroid, B cells, Cardiac myocytes, Bone marrow, Skin, Skeletal muscle, Whole blood, Bone, Pituitary, Prostate, Placenta, Nk cells, Eye

Animal Models for Septic Shock or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Septic Shock:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6TNF, POMC, ANGPT2, IL10, CASP1, F5
2MP:00053708.5TNF, SERPINC1, POMC, IL10, F5
3MP:00020068.1TNF, POMC, MIF, IL10, CASP1, TREM1
4MP:00036318.0TNF, SERPINC1, POMC, IL10, CASP1, F5
5MP:00053857.4CFP, TNF, SERPINC1, POMC, ANGPT2, IL10
6MP:00053847.2TNF, POMC, DIO3, MIF, IL10, CASP1
7MP:00053977.0TNFSF12, TNF, SERPINC1, POMC, MIF, IL10
8MP:00053876.5CFP, TNFSF12, TNF, SERPINC1, POMC, ANGPT2
9MP:00107685.8POMC, SERPINC1, TNF, CFP, AVP, DIO3
10MP:00053765.4TREM1, AVP, CFP, TNF, SERPINC1, POMC

Publications for Septic Shock

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52PubMed
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Articles related to Septic Shock:

(show top 50)    (show all 1052)
idTitleAuthorsYear
1
Novel pharmacologic treatment attenuates septic shock and improves long-term survival. (23889949)
2013
2
Alteration of plasma phospholipid fatty acid profile in patients with septic shock. (23954620)
2013
3
Current recommendations for diagnosis and management of sepsis and septic shock. (24201922)
2013
4
Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock: an observational study. (23859579)
2013
5
Temporizing surgical management improves outcome in patients with Vibrio necrotizing fasciitis complicated with septic shock on admission. (24138809)
2013
6
Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock. (23317877)
2013
7
The use of the pulse oximetric saturation/fraction of inspired oxygen ratio for risk stratification of patients with severe sepsis and septic shock. (23726018)
2013
8
Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. (24150174)
2013
9
Clinical course of sepsis, severe sepsis, and septic shock in a cohort of infected patients from ten Colombian hospitals. (23883312)
2013
10
Is shock index associated with outcome in children with sepsis/septic shock?*. (23962830)
2013
11
CRISPLD2 is expressed at low levels during septic shock and is associated with procalcitonin. (23799041)
2013
12
Salivary cortisol estimation to assess adrenal status in children with fluid unresponsive septic shock. (23502658)
2013
13
Difference in venous-arterial carbon dioxide in septic shock. (24280813)
2013
14
Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: a prospective observational study in 12 university hospitals in Korea. (23166410)
2012
15
Polymorphic variants in exon 8 at the 3' UTR of the HLA-G gene are associated with septic shock in critically ill patients. (23107167)
2012
16
Invasive pneumonia and septic shock in infants as a presentation of cystic fibrosis with vitamin-deficiency. (22684986)
2012
17
Concerns of the anesthesiologist: anesthetic induction in severe sepsis or septic shock patients. (22870358)
2012
18
Real-time continuous glucose monitoring in an intensive care unit: better accuracy in patients with septic shock. (22512288)
2012
19
Controversial treatment of a victim of severe head injury complicated by septic shock and acute respiratory distress syndrome. (23754904)
2011
20
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. (19062078)
2009
21
Urinary liver-type fatty acid-binding protein in septic shock: effect of polymyxin B-immobilized fiber hemoperfusion. (18838948)
2009
22
The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome. (19141631)
2009
23
Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes. (19539650)
2009
24
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. (18839141)
2008
25
Continuous hemodiafiltration with PMMA Hemofilter in the treatment of patients with septic shock. (18327291)
2008
26
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. (17959595)
2007
27
Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent. (17541549)
2007
28
Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. (17202308)
2007
29
Potential benefits of non-anti-infective treatments of septic shock: a critical analysis of literature]. (17395418)
2007
30
Implementation of an evidence-based "standard operating procedure" and outcome in septic shock. (16484902)
2006
31
Fever control in septic shock: beneficial or harmful? (15897803)
2005
32
Septic shock: diagnosis and management]. (15940907)
2005
33
Drotrecogin alpha (activated) in neonatal septic shock. (15804668)
2005
34
Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients. (16175347)
2005
35
Can we predict septic shock in patients with hospital-acquired pneumonia? (16356255)
2005
36
Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. (12500222)
2003
37
Response of tumour necrosis factor-alpha to delayed in vitro monocyte stimulation in patients with septic shock is related to outcome. (11869172)
2002
38
Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma. (11685298)
2001
39
Xanthine oxidase activity and blood glutathione redox ratio in infants and children with septic shock syndrome. (11280638)
2001
40
New insights in the regulation of leukocytosis and the role played by leukocytes in septic shock. (11813508)
2001
41
Protection from septic shock by neutralization of macrophage migration inhibitory factor. (10655104)
2000
42
Endothelin-1 and blood pressure after inhibition of nitric oxide synthesis in human septic shock. (9892594)
1999
43
Cellular activation mechanisms in septic shock. (9560358)
1998
44
Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. (9142022)
1997
45
Circulating methemoglobin and nitrite/nitrate concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock. (9295837)
1997
46
A comparison of the adrenocortical response during septic shock and after complete recovery. (8905423)
1996
47
High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock. (7798670)
1995
48
The role of bactericidal/permeability-increasing protein in the treatment of primate bacteremia and septic shock. (8195314)
1994
49
Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. (8147551)
1994
50
Extensive cellulitis with septic shock caused by Vibrio vulnificus infection--a case report with review of literature. (1791352)
1991

Variations for Septic Shock

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Expression for genes affiliated with Septic Shock

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Septic Shock

Search GEO for disease gene expression data for Septic Shock.

Pathways for genes affiliated with Septic Shock

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 30KEGG, 54R&D Systems, 55Reactome, 57SinoBiological
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Pathways related to Septic Shock according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CASP1, TNF
29.9MIF, TNF
39.7IL10, TNF
49.7IL10, TNF
59.7IL10, TNF
69.7IL10, TNF
7
Show member pathways
9.7TNF, IL10
8
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.5TNFSF12, TNF, CASP1
9
Show member pathways
9.5CASP1, TNF, TNFSF12
10
Show member pathways
9.5CASP1, TNF, TNFSF12
119.5CASP1, IL10, TNF
12
Show member pathways
thioredoxin pathway38
9.5TNF, SAA2, DIO3
139.4IL10, TNF, AVP
14
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4TNF, ANGPT2, IL10
15
Show member pathways
8.9TNFSF12, TNF, ANGPT2, IL10
16
Show member pathways
8.7TNFSF12, TNF, ANGPT2, IL10, CASP1
17
Show member pathways
8.4SERPINC1, ANGPT2, F5, TREM1
18
Show member pathways
8.3CASP1, IL10, MIF, ANGPT2, TNF, TNFSF12

Compounds for genes affiliated with Septic Shock

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Septic Shock according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1cdp5714510.1IL10, TNF
2interferon gamma4510.0IL10, TNF
3inogatran4510.0F5, SERPINC1
4ecarin459.9SERPINC1, F5
5hirugen459.9F5, SERPINC1
6spectrozyme459.9F5, SERPINC1
7nafamostat mesilate459.9F5, SERPINC1
8danaparoid459.9SERPINC1, F5
9peptidoglycan45 2910.9CASP1, IL10, TNF
10uric acid45 2410.9F5, AVP, CASP1
11pentoxifylline45 1110.8CASP1, TNF, IL10
12mycophenolate mofetil45 51 1111.8F5, IL10, TNF
13ximelagatran45 1110.8F5, SERPINC1
14ancrod459.8SERPINC1, F5
15infliximab45 51 1111.8TNF, ANGPT2, IL10
16as 10145 6110.8IL10, CASP1, MIF
17heparinoids459.7F5, SERPINC1
18dextran sulfate459.6F5, SERPINC1, CFP
19tacrolimus45 51 1111.6TNF, IL10, CASP1, F5
20fondaparinux459.6SERPINC1, F5
21catecholamine459.5AVP, MIF, POMC
22ulinastatin459.5IL10, SERPINC1, TNF
23thalidomide45 51 61 1112.5IL10, MIF, TNF
24aspirin45 51 29 2412.5SERPINC1, POMC, F5, CASP1
25desmopressin45 61 29 1112.5SERPINC1, POMC, F5, AVP
26sb 20358045 6110.4CASP1, TNF, MIF, IL10
27h2o2459.4TNF, POMC, ANGPT2, MIF, CASP1
28progestin459.4POMC, SERPINC1, ANGPT2, F5
29corticosterone45 61 2411.4POMC, MIF, IL10
30cyclosporin a45 29 6111.3POMC, TNF, ANGPT2, CASP1, IL10
31ascorbic acid45 2410.3CFP, SERPINC1, F5, POMC
32fibrinogen459.3TNF, SERPINC1, ANGPT2, F5
33aprotinin45 1110.3F5, SERPINC1, IL10
34gabexate mesilate459.3SERPINC1, IL10, F5, TNF
35endotoxin459.3TNF, MIF, F5, CASP1, IL10
36steroid459.3MIF, POMC, AVP, F5, ANGPT2
37hydrocortisone45 3 61 1112.3MIF, IL10, TNF, POMC, F5
38chloroquine45 3 51 29 1113.3IL10, SERPINC1, TNF
39dithiothreitol459.2DIO3, CASP1, MIF
40prostacyclin459.2TNF, IL10, F5, SERPINC1
41estrogen458.8CASP1, POMC, SERPINC1, ANGPT2, F5, MIF
42nitric oxide45 24 1110.6AVP, TNF, CASP1, ANGPT2, MIF, IL10
43alanine458.5SERPINC1, AVP, F5, DIO3, MIF, POMC
44creatinine458.5AVP, F5, CASP1, MIF, ANGPT2, POMC
45cysteine458.5AVP, MIF, F5, ANGPT2, CFP, DIO3
46pge2458.4MIF, CASP1, ANGPT2, SERPINC1, POMC, TNF
47serine458.3AVP, TNF, SERPINC1, ANGPT2, POMC, F5
48vegf458.1F5, TNF, CASP1, IL10, MIF, ANGPT2
49calcium45 51 24 1110.4TREM1, F5, CASP1, PLN, MIF, ANGPT2
50dexamethasone45 51 29 1110.3SERPINC1, DIO3, SAA2, POMC, TNF, AVP

GO Terms for genes affiliated with Septic Shock

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16Gene Ontology
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Cellular components related to Septic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.7CFP, TNF, SERPINC1, POMC, ANGPT2, MIF
2extracellular spaceGO:0056156.5F5, AVP, CFP, TNFSF12, TNF, SERPINC1

Biological processes related to Septic Shock according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.1MIF, TNF
2receptor biosynthetic processGO:03280010.0IL10, TNF
3negative regulation of cytokine secretion involved in immune responseGO:0027409.9IL10, TNF
4negative regulation of growth of symbiont in hostGO:0441309.9IL10, TNF
5positive regulation of peptidyl-serine phosphorylationGO:0331389.8AVP, TNF, MIF
6response to hypoxiaGO:0016669.8TNF, ANGPT2, CASP1
7negative regulation of interleukin-6 productionGO:0327159.8IL10, TNF
8response to testosteroneGO:0335749.8AVP, PLN
9response to activityGO:0148239.7IL10, ANGPT2, TNF
10positive regulation of cytokine secretionGO:0507159.6IL10, MIF, TNF
11negative regulation of tumor necrosis factor productionGO:0327209.6IL10, POMC
12cell-cell signalingGO:0072679.4IL10, POMC, AVP
13signal transductionGO:0071659.1AVP, TNFSF12, POMC, ANGPT2, CASP1
14blood coagulationGO:0075968.6TREM1, F5, ANGPT2, SERPINC1
15innate immune responseGO:0450878.4CFP, MIF, CASP1, TREM1

Molecular functions related to Septic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.8TNF, TNFSF12
2receptor bindingGO:0051028.7MIF, ANGPT2, POMC, TNFSF12, AVP
3cytokine activityGO:0051258.6TNFSF12, TNF, MIF, IL10

Products for genes affiliated with Septic Shock

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Sources for Septic Shock

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet