MCID: SPT013
MIFTS: 60

Septic Shock malady

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Summaries for Septic Shock

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Wikipedia:65 Septic shock is a medical condition as a result of severe infection and sepsis, though the microbe may... more...

MalaCards based summary: Septic Shock, also known as shock septic, is related to adult respiratory distress syndrome and pneumonia. An important gene associated with Septic Shock is TNF (tumor necrosis factor), and among its related pathways are Cellular roles of Anthrax toxin and Immune response MIF mediated glucocorticoid regulation. The drugs dexamethasone and dexamethasone acetate and the compounds cdp571 and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include monocytes, kidney and neutrophil, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Septic Shock

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Sources:
46OMIM, 62UMLS, 44Novoseek, 25ICD10
See all sources

Septic Shock, Aliases & Descriptions:

Name: Septic Shock 46 62
 
Shock Septic 44


Classifications:



External Ids:

ICD1025 R57.2

Related Diseases for Septic Shock

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Diseases related to Septic Shock via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1adult respiratory distress syndrome31.0TNF, MIF, F5
2pneumonia31.0AVP, TNF, IL10, TREM1
3meningitis30.9CFP, AVP
4hypertension30.7F5, POMC, AVP
5meningococcemia30.6F5, SERPINC1
6hypothyroidism30.5AVP, POMC, DIO3
7coronary thrombosis30.5SERPINC1
8sepsis30.4ANGPT2, SERPINC1, TNF, AVP, MIF, IL10
9protein s deficiency30.3SERPINC1, F5
10acute myocardial infarction30.3MIF, ANGPT2, SERPINC1
11tuberculosis30.1TNF, POMC, MIF, IL10, TREM1
12protein c deficiency30.1CFP, SERPINC1, F5
13plasmodium falciparum malaria30.1IL10, MIF
14arthritis30.0TNF, POMC, MIF, IL10, CASP1
15liver cirrhosis30.0ANGPT2, SERPINC1, AVP
16antiphospholipid syndrome30.0F5, SERPINC1
17respiratory failure29.9SERPINC1, TNF
18malaria29.9CFP, TNF, MIF, IL10
19rheumatoid arthritis29.8TNF, SAA2, ANGPT2, MIF, IL10, CASP1
20disseminated intravascular coagulation10.6
21purpura10.6
22branch retinal artery occlusion10.6F5
23melancholia10.6POMC
24pituitary apoplexy10.5POMC
25blindness10.5
26endotheliitis10.5
27central retinal vein occlusion10.5F5
28pyelonephritis10.5
29bacteremia10.5
30congestive heart failure10.5AVP
31fasciitis10.4
32syndrome of inappropriate antidiuretic hormone10.4POMC, AVP
33neurogenic diabetes insipidus10.4AVP, POMC
34leukemia10.4
35blau syndrome10.4TNF
36panhypopituitarism10.4AVP, POMC
37diabetes insipidus10.4AVP, POMC
38craniopharyngioma10.4AVP, POMC
39acute pyelonephritis10.4
40necrotizing fasciitis10.4
41peritonitis10.4
42cardiogenic shock10.4
43afibrinogenemia10.3CFP, F5
44macular holes10.3ANGPT2, MIF
45sneddon syndrome10.3SERPINC1
46brain injury10.3
47hepatitis10.3
48myocardial infarction10.3
49critical illness polyneuropathy10.3
50melioidosis10.3

Graphical network of the top 20 diseases related to Septic Shock:



Diseases related to septic shock

Symptoms for Septic Shock

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Drugs & Therapeutics for Septic Shock

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Genetic Tests for Septic Shock

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Anatomical Context for Septic Shock

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MalaCards organs/tissues related to Septic Shock:

32
Monocytes, Kidney, Neutrophil, Testes, Brain, Heart, Endothelial, Liver, Lung, Skin, Myeloid, Thyroid, T cells, Bone marrow, Bone, Whole blood, Skeletal muscle, B cells, Cardiac myocytes, Pituitary, Eye, Placenta, Prostate, Nk cells

Animal Models for Septic Shock or affiliated genes

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MGI Mouse Phenotypes related to Septic Shock:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6TNF, POMC, ANGPT2, IL10, CASP1, F5
2MP:00053708.5TNF, SERPINC1, POMC, IL10, F5
3MP:00020068.1TNF, POMC, MIF, IL10, CASP1, TREM1
4MP:00036318.0TNF, SERPINC1, POMC, IL10, CASP1, F5
5MP:00053857.4CFP, TNF, SERPINC1, POMC, ANGPT2, IL10
6MP:00053847.2TNF, POMC, DIO3, MIF, IL10, CASP1
7MP:00053977.0TNFSF12, TNF, SERPINC1, POMC, MIF, IL10
8MP:00053876.5CFP, TNFSF12, TNF, SERPINC1, POMC, ANGPT2
9MP:00107685.8POMC, SERPINC1, TNF, CFP, AVP, DIO3
10MP:00053765.4TREM1, AVP, CFP, TNF, SERPINC1, POMC

Publications for Septic Shock

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Articles related to Septic Shock:

(show top 50)    (show all 1087)
idTitleAuthorsYear
1
Sustained Elevation of Resistin, NGAL and IL-8 Are Associated with Severe Sepsis/Septic Shock in the Emergency Department. (25343379)
2014
2
Spontaneous massive splenic infarction in the setting of renal transplant and septic shock: a case report and review of the literature. (25317176)
2014
3
Novel pharmacologic treatment attenuates septic shock and improves long-term survival. (23889949)
2013
4
Alteration of plasma phospholipid fatty acid profile in patients with septic shock. (23954620)
2013
5
Current recommendations for diagnosis and management of sepsis and septic shock. (24201922)
2013
6
Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock: an observational study. (23859579)
2013
7
Temporizing surgical management improves outcome in patients with Vibrio necrotizing fasciitis complicated with septic shock on admission. (24138809)
2013
8
Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock. (23317877)
2013
9
The use of the pulse oximetric saturation/fraction of inspired oxygen ratio for risk stratification of patients with severe sepsis and septic shock. (23726018)
2013
10
Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. (24150174)
2013
11
Clinical course of sepsis, severe sepsis, and septic shock in a cohort of infected patients from ten Colombian hospitals. (23883312)
2013
12
Is shock index associated with outcome in children with sepsis/septic shock?*. (23962830)
2013
13
CRISPLD2 is expressed at low levels during septic shock and is associated with procalcitonin. (23799041)
2013
14
Salivary cortisol estimation to assess adrenal status in children with fluid unresponsive septic shock. (23502658)
2013
15
Difference in venous-arterial carbon dioxide in septic shock. (24280813)
2013
16
Epidemiological and clinical characteristics of community-acquired severe sepsis and septic shock: a prospective observational study in 12 university hospitals in Korea. (23166410)
2012
17
Polymorphic variants in exon 8 at the 3' UTR of the HLA-G gene are associated with septic shock in critically ill patients. (23107167)
2012
18
Invasive pneumonia and septic shock in infants as a presentation of cystic fibrosis with vitamin-deficiency. (22684986)
2012
19
Concerns of the anesthesiologist: anesthetic induction in severe sepsis or septic shock patients. (22870358)
2012
20
Real-time continuous glucose monitoring in an intensive care unit: better accuracy in patients with septic shock. (22512288)
2012
21
Controversial treatment of a victim of severe head injury complicated by septic shock and acute respiratory distress syndrome. (23754904)
2011
22
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. (19062078)
2009
23
Urinary liver-type fatty acid-binding protein in septic shock: effect of polymyxin B-immobilized fiber hemoperfusion. (18838948)
2009
24
The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome. (19141631)
2009
25
Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes. (19539650)
2009
26
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. (18839141)
2008
27
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. (17959595)
2007
28
Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent. (17541549)
2007
29
Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. (17202308)
2007
30
Potential benefits of non-anti-infective treatments of septic shock: a critical analysis of literature]. (17395418)
2007
31
Implementation of an evidence-based "standard operating procedure" and outcome in septic shock. (16484902)
2006
32
Fever control in septic shock: beneficial or harmful? (15897803)
2005
33
Septic shock: diagnosis and management]. (15940907)
2005
34
Drotrecogin alpha (activated) in neonatal septic shock. (15804668)
2005
35
Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients. (16175347)
2005
36
Can we predict septic shock in patients with hospital-acquired pneumonia? (16356255)
2005
37
Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. (12500222)
2003
38
Response of tumour necrosis factor-alpha to delayed in vitro monocyte stimulation in patients with septic shock is related to outcome. (11869172)
2002
39
Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma. (11685298)
2001
40
Xanthine oxidase activity and blood glutathione redox ratio in infants and children with septic shock syndrome. (11280638)
2001
41
New insights in the regulation of leukocytosis and the role played by leukocytes in septic shock. (11813508)
2001
42
Protection from septic shock by neutralization of macrophage migration inhibitory factor. (10655104)
2000
43
Endothelin-1 and blood pressure after inhibition of nitric oxide synthesis in human septic shock. (9892594)
1999
44
Cellular activation mechanisms in septic shock. (9560358)
1998
45
Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. (9142022)
1997
46
Circulating methemoglobin and nitrite/nitrate concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock. (9295837)
1997
47
A comparison of the adrenocortical response during septic shock and after complete recovery. (8905423)
1996
48
High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock. (7798670)
1995
49
The role of bactericidal/permeability-increasing protein in the treatment of primate bacteremia and septic shock. (8195314)
1994
50
Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. (8147551)
1994

Variations for Septic Shock

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Expression for genes affiliated with Septic Shock

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Expression patterns in normal tissues for genes affiliated with Septic Shock

Search GEO for disease gene expression data for Septic Shock.

Pathways for genes affiliated with Septic Shock

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Pathways related to Septic Shock according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CASP1, TNF
29.9MIF, TNF
39.7IL10, TNF
49.7IL10, TNF
59.7IL10, TNF
69.7IL10, TNF
7
Show member pathways
9.7TNF, IL10
8
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.5TNFSF12, TNF, CASP1
9
Show member pathways
9.5CASP1, TNF, TNFSF12
10
Show member pathways
9.5CASP1, TNF, TNFSF12
119.5CASP1, IL10, TNF
12
Show member pathways
thioredoxin pathway37
9.5TNF, SAA2, DIO3
139.4IL10, TNF, AVP
14
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4TNF, ANGPT2, IL10
15
Show member pathways
8.9TNFSF12, TNF, ANGPT2, IL10
16
Show member pathways
8.7TNFSF12, TNF, ANGPT2, IL10, CASP1
17
Show member pathways
8.4SERPINC1, ANGPT2, F5, TREM1
18
Show member pathways
8.3CASP1, IL10, MIF, ANGPT2, TNF, TNFSF12

Compounds for genes affiliated with Septic Shock

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Compounds related to Septic Shock according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1cdp5714410.1TNF, IL10
2interferon gamma4410.0TNF, IL10
3inogatran4410.0F5, SERPINC1
4ecarin449.9SERPINC1, F5
5hirugen449.9SERPINC1, F5
6spectrozyme449.9SERPINC1, F5
7nafamostat mesilate449.9F5, SERPINC1
8danaparoid449.9F5, SERPINC1
9peptidoglycan44 2810.9TNF, IL10, CASP1
10uric acid44 2410.9AVP, CASP1, F5
11pentoxifylline44 1110.8CASP1, IL10, TNF
12mycophenolate mofetil44 50 1111.8TNF, IL10, F5
13ximelagatran44 1110.8SERPINC1, F5
14ancrod449.8SERPINC1, F5
15infliximab44 50 1111.8IL10, ANGPT2, TNF
16as 10144 6110.8CASP1, IL10, MIF
17heparinoids449.7F5, SERPINC1
18tacrolimus44 50 1111.6TNF, IL10, CASP1, F5
19dextran sulfate449.6CFP, SERPINC1, F5
20fondaparinux449.6F5, SERPINC1
21catecholamine449.5MIF, POMC, AVP
22ulinastatin449.5TNF, SERPINC1, IL10
23thalidomide44 50 61 1112.5TNF, MIF, IL10
24aspirin44 50 28 2412.5F5, CASP1, POMC, SERPINC1
25desmopressin44 61 28 1112.5F5, POMC, SERPINC1, AVP
26sb 20358044 6110.4CASP1, IL10, MIF, TNF
27h2o2449.4TNF, POMC, ANGPT2, MIF, CASP1
28progestin449.4SERPINC1, POMC, ANGPT2, F5
29corticosterone44 61 2411.4POMC, MIF, IL10
30cyclosporin a44 28 6111.3TNF, POMC, ANGPT2, IL10, CASP1
31ascorbic acid44 2410.3CFP, SERPINC1, POMC, F5
32fibrinogen449.3TNF, SERPINC1, ANGPT2, F5
33chloroquine44 2 50 28 1113.3TNF, SERPINC1, IL10
34aprotinin44 1110.3F5, IL10, SERPINC1
35gabexate mesilate449.3TNF, SERPINC1, IL10, F5
36endotoxin449.3TNF, MIF, IL10, CASP1, F5
37steroid449.3AVP, POMC, ANGPT2, MIF, F5
38hydrocortisone44 2 61 1112.3TNF, POMC, MIF, IL10, F5
39dithiothreitol449.2DIO3, MIF, CASP1
40prostacyclin449.2F5, IL10, SERPINC1, TNF
41estrogen448.8SERPINC1, POMC, ANGPT2, MIF, CASP1, F5
42nitric oxide44 24 1110.6AVP, TNF, ANGPT2, MIF, IL10, CASP1
43alanine448.5AVP, SERPINC1, POMC, DIO3, MIF, F5
44creatinine448.5AVP, SERPINC1, POMC, ANGPT2, MIF, CASP1
45cysteine448.5AVP, CFP, DIO3, ANGPT2, MIF, CASP1
46pge2448.4TNF, SERPINC1, POMC, ANGPT2, MIF, IL10
47serine448.3AVP, TNF, SERPINC1, POMC, ANGPT2, MIF
48vegf448.1TNF, SERPINC1, POMC, ANGPT2, MIF, IL10
49calcium44 50 24 1110.4AVP, ANGPT2, MIF, PLN, CASP1, F5
50dexamethasone44 50 28 1110.3CASP1, AVP, TNF, SERPINC1, POMC, SAA2

GO Terms for genes affiliated with Septic Shock

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Cellular components related to Septic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.7CFP, TNF, SERPINC1, POMC, ANGPT2, MIF
2extracellular spaceGO:0056156.5F5, AVP, CFP, TNFSF12, TNF, SERPINC1

Biological processes related to Septic Shock according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.1MIF, TNF
2receptor biosynthetic processGO:03280010.0IL10, TNF
3negative regulation of cytokine secretion involved in immune responseGO:0027409.9IL10, TNF
4negative regulation of growth of symbiont in hostGO:0441309.9IL10, TNF
5positive regulation of peptidyl-serine phosphorylationGO:0331389.8AVP, TNF, MIF
6response to hypoxiaGO:0016669.8TNF, ANGPT2, CASP1
7negative regulation of interleukin-6 productionGO:0327159.8IL10, TNF
8response to testosteroneGO:0335749.8AVP, PLN
9response to activityGO:0148239.7IL10, ANGPT2, TNF
10positive regulation of cytokine secretionGO:0507159.6IL10, MIF, TNF
11negative regulation of tumor necrosis factor productionGO:0327209.6IL10, POMC
12cell-cell signalingGO:0072679.4IL10, POMC, AVP
13signal transductionGO:0071659.1AVP, TNFSF12, POMC, ANGPT2, CASP1
14blood coagulationGO:0075968.6TREM1, F5, ANGPT2, SERPINC1
15innate immune responseGO:0450878.4CFP, MIF, CASP1, TREM1

Molecular functions related to Septic Shock according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.8TNF, TNFSF12
2receptor bindingGO:0051028.7MIF, ANGPT2, POMC, TNFSF12, AVP
3cytokine activityGO:0051258.6TNFSF12, TNF, MIF, IL10

Products for genes affiliated with Septic Shock

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Sources for Septic Shock

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet