MCID: SPT002
MIFTS: 33

Septicemic Plague

Categories: Infectious diseases

Aliases & Classifications for Septicemic Plague

MalaCards integrated aliases for Septicemic Plague:

Name: Septicemic Plague 12 14
Plague, Septicemic 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3481
ICD10 33 A20.7
ICD9CM 35 020.2
MeSH 42 D010930
SNOMED-CT 64 9012003
UMLS 69 C0152936

Summaries for Septicemic Plague

Disease Ontology : 12 A plague that results_in infection located in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has symptom fever, has symptom chills, has symptom prostration, has symptom abdominal pain, has symptom shock and has symptom bleeding into skin and other organs.

MalaCards based summary : Septicemic Plague, also known as plague, septicemic, is related to plague and pneumonic plague. An important gene associated with Septicemic Plague is IFNAR1 (Interferon Alpha And Beta Receptor Subunit 1), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Streptomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin and colon, and related phenotypes are cellular and hematopoietic system

Wikipedia : 72 Septicemic (or septicaemic) plague is one of the three main forms of plague. It is caused by Yersinia... more...

Related Diseases for Septicemic Plague

Graphical network of the top 20 diseases related to Septicemic Plague:



Diseases related to Septicemic Plague

Symptoms & Phenotypes for Septicemic Plague

MGI Mouse Phenotypes related to Septicemic Plague:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CCNE1 CXCR2 IFNAR1 IRF3 MYD88 PLG
2 hematopoietic system MP:0005397 9.97 CCNE1 CXCR2 IFNAR1 IFNB1 IL17A MYD88
3 homeostasis/metabolism MP:0005376 9.92 PLG TLR7 CXCR2 IFNAR1 IFNB1 IL17A
4 immune system MP:0005387 9.91 PLG TLR7 CCNE1 CXCR2 IFNAR1 IFNB1
5 endocrine/exocrine gland MP:0005379 9.88 CCNE1 CXCR2 IFNAR1 IL17A MYD88 PLG
6 digestive/alimentary MP:0005381 9.83 CCNE1 IFNAR1 IL17A MYD88 PLG
7 neoplasm MP:0002006 9.63 CCNE1 CXCR2 IFNAR1 IFNB1 MYD88 PLG
8 renal/urinary system MP:0005367 9.43 CXCR2 IFNAR1 IL17A MYD88 PLG TLR7
9 skeleton MP:0005390 9.1 CCNE1 CXCR2 IFNAR1 IFNB1 IL17A MYD88

Drugs & Therapeutics for Septicemic Plague

Drugs for Septicemic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Gentamicins Phase 2, Phase 3
5
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
6
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
7 Antimalarials Phase 2
8 Antiparasitic Agents Phase 2
9 Antiprotozoal Agents Phase 2
10 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
11 Cytochrome P-450 Enzyme Inhibitors Phase 2
12 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Treatment and Diagnosis of Plague Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
2 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline

Search NIH Clinical Center for Septicemic Plague

Genetic Tests for Septicemic Plague

Anatomical Context for Septicemic Plague

MalaCards organs/tissues related to Septicemic Plague:

39
Skin, Colon

Publications for Septicemic Plague

Articles related to Septicemic Plague:

id Title Authors Year
1
Bioluminescent tracking of colonization and clearance dynamics of plasmid-deficient Yersinia pestis strains in a mouse model of septicemic plague. ( 24333143 )
2013
2
Investigation of a researcher's death due to septicemic plague. ( 21714673 )
2011
3
Septicemic plague in a community hospital in California. ( 18541761 )
2008
4
Persistent Yersinia pestis antigens in ischemic tissues of a patient with septicemic plague. ( 16084958 )
2005
5
Septicemic plague in New Mexico. ( 3794395 )
1987
6
Septicemic plague in a 14-month-old child. ( 3945561 )
1986
7
Septicemic plague that mimics Reye's syndrome. ( 433859 )
1979

Variations for Septicemic Plague

Expression for Septicemic Plague

Search GEO for disease gene expression data for Septicemic Plague.

Pathways for Septicemic Plague

Pathways related to Septicemic Plague according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CXCR2 IFNAR1 IFNB1 IL17A IRF3 MYD88
2
Show member pathways
12.99 IFNAR1 IFNB1 IL17A IRF3 MYD88
3
Show member pathways
12.49 IFNAR1 IFNB1 IRF3 MYD88 TLR7
4 12.33 CCNE1 IFNAR1 IFNB1 IRF3
5
Show member pathways
12.33 IFNAR1 IFNB1 IRF3 MYD88 TLR7
6
Show member pathways
12.19 IFNAR1 IFNB1 IRF3
7 12.12 IL17A IRF3 MYD88 TLR7
8
Show member pathways
11.86 CCNE1 IFNAR1 IFNB1 IRF3 MYD88 PLG
9
Show member pathways
11.83 IFNB1 MYD88 TLR7
10 11.66 IFNAR1 IFNB1 IRF3
11
Show member pathways
11.47 IFNAR1 IFNB1 IL17A IRF3
12
Show member pathways
11.36 MYD88 PLG
13
Show member pathways
10.82 IFNAR1 IRF3
14 10.61 IFNAR1 IFNB1

GO Terms for Septicemic Plague

Biological processes related to Septicemic Plague according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.73 CXCR2 IFNB1 MYD88
2 inflammatory response GO:0006954 9.71 CXCR2 IL17A MYD88 TLR7
3 response to lipopolysaccharide GO:0032496 9.65 IFNAR1 IRF3 MYD88
4 positive regulation of type I interferon production GO:0032481 9.58 IRF3 MYD88
5 positive regulation of interleukin-6 production GO:0032755 9.58 MYD88 TLR7
6 toll-like receptor signaling pathway GO:0002224 9.57 MYD88 TLR7
7 response to exogenous dsRNA GO:0043330 9.55 IFNB1 IRF3
8 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.54 MYD88 TLR7
9 response to virus GO:0009615 9.54 IFNAR1 IFNB1 MYD88
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.52 IRF3 MYD88
11 regulation of type I interferon-mediated signaling pathway GO:0060338 9.51 IFNAR1 IFNB1
12 positive regulation of interferon-beta production GO:0032728 9.49 IFNAR1 IRF3
13 toll-like receptor 9 signaling pathway GO:0034162 9.46 MYD88 TLR7
14 defense response to virus GO:0051607 9.46 IFNAR1 IFNB1 IRF3 TLR7
15 cellular response to dsRNA GO:0071359 9.32 IFNB1 IRF3
16 positive regulation of interleukin-23 production GO:0032747 9.26 IL17A MYD88
17 type I interferon signaling pathway GO:0060337 9.26 IFNAR1 IFNB1 IRF3 MYD88
18 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.13 IL17A
19 type I interferon biosynthetic process GO:0045351 8.8 IFNAR1 IRF3 MYD88

Sources for Septicemic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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