MCID: SRT004
MIFTS: 49

Serotonin Syndrome malady

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Serotonin Syndrome

Aliases & Descriptions for Serotonin Syndrome:

Name: Serotonin Syndrome 56 52
Malignant Carcinoid Syndrome 69
Serotonergic Syndrome 56
Serotonin Toxidrome 56
Serotonin Toxicity 56
Serotonin Storm 56

Characteristics:

Orphanet epidemiological data:

56
serotonin syndrome
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA43116
MESH via Orphanet 43 D020230
UMLS via Orphanet 70 C0699828

Summaries for Serotonin Syndrome

MalaCards based summary : Serotonin Syndrome, also known as malignant carcinoid syndrome, is related to ornithosis and dry eye syndrome. An important gene associated with Serotonin Syndrome is HTR3A (5-Hydroxytryptamine Receptor 3A), and among its related pathways/superpathways are Peptide ligand-binding receptors and Serotonergic synapse. The drugs Norepinephrine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and hypothalamus, and related phenotypes are Decreased viability and behavior/neurological

Wikipedia : 71 Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic... more...

Related Diseases for Serotonin Syndrome

Diseases related to Serotonin Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 ornithosis 10.3 HTR3A MAOA SLC6A4
2 dry eye syndrome 10.3 HTR1A HTR2A SLC6A4
3 anodontia 10.3 HTR1A HTR3A SLC6A4
4 polyneuropathy 10.3 HTR1A HTR2A
5 conjunctival pigmentation 10.3 MAOA MAOB SLC6A4
6 neurogenic bladder 10.3 HTR2A MAOA SLC6A4
7 adult brainstem astrocytoma 10.3 HTR1A MAOA SLC6A4
8 dissociative disorder 10.3 CYP3A4 MAOA MAOB
9 kidney pelvis papillary carcinoma 10.3 HTR1A MAOA SLC6A4
10 waardenburg's syndrome 10.2 HTR1A HTR2A SLC6A4
11 intrahepatic gall duct cancer 10.2 HTR2A MAOA SLC6A4
12 chronic eosinophilic pneumonia 10.2 HTR1A MAOA SLC6A4
13 strongyloidiasis 10.2 MAOA MAOB SLC6A4
14 nephrogenic adenoma of the urethra 10.2 HTR3A MAOB SLC6A4
15 primary angle-closure glaucoma 10.2 HTR1A HTR2A SLC6A4
16 antisocial personality disorder 10.2 HTR1A HTR2A
17 renpenning syndrome 10.2 HTR1A HTR3A MAOA SLC6A4
18 cytomegalic congenital adrenal hypoplasia 10.2 HTR2A HTR3A MAOA SLC6A4
19 alzheimer disease 17 10.2 HTR1A HTR2A SLC6A4
20 hypoglycemic coma 10.2 HTR1A HTR2A MAOA SLC6A4
21 multiple personality disorder 10.2 HTR1A HTR2A MAOA SLC6A4
22 pyromania 10.2 HTR2A MAOA MAOB SLC6A4
23 aryepiglottic fold cancer 10.2 HTR1A HTR2A
24 mucinous adenocarcinoma 10.2 CYP2D6 MAOA SLC6A4
25 hereditary multiple exostoses 10.2 HTR2A MAOA SLC6A4
26 lichen disease 10.2 HTR1A HTR2A MAOA SLC6A4
27 mixed lacrimal gland cancer 10.2 HTR1A HTR3A TAC1
28 mandibular cancer 10.2 HTR1A HTR3A SLC6A4 SST
29 gmppa-cdg 10.2 CHGA GHRH SST
30 hypereosinophilic syndrome 10.2 CYP2D6 MAOA SLC6A4
31 deafness, autosomal recessive 20 10.2 HTR3A SLC6A4 TAC1
32 lethal congenital contracture syndrome 1 10.1 MAOA MAOB NOTCH1
33 postencephalitic parkinson disease 10.1 HTR1A HTR2A HTR3A MAOA SLC6A4
34 fechtner syndrome 10.1 HTR1A HTR2A HTR3A MAOA SLC6A4
35 chagas disease 10.1 HTR2A HTR3A PYY SLC6A4
36 cecal benign neoplasm 10.1 HTR1A HTR2A MAOA MAOB SLC6A4
37 cowden syndrome 3 10.1 CHGA MEN1 SST
38 epithelioid type angiomyolipoma 10.1 CYP2D6 HTR2A MAOB SLC6A4
39 tinea pedis 10.1 CYP2D6 CYP3A4 HTR1A MAOA SLC6A4
40 benign epilepsy with centrotemporal spikes 10.1 HTR1A HTR2A MAOA MAOB SLC6A4
41 tactile epilepsy 10.1 CYP3A4 NOTCH1 OXT
42 immune system organ benign neoplasm 10.1 GHRH MEN1 SST
43 tuberculous peritonitis 10.1 CHGA HTR3A SLC6A4 TAC1
44 urethra clear cell adenocarcinoma 10.1 GHRH MEN1 SST
45 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.1 GHRH HTR2A PYY SLC6A4
46 vestibular gland benign neoplasm 10.1 CHGA MEN1 SST
47 autoimmune pancreatitis 10.0 CHGA GAST
48 preeclampsia/eclampsia 5 10.0 HTR1A HTR2A HTR3A MAOA MAOB SLC6A4
49 adamantinous craniopharyngioma 10.0 GHRH MEN1 SST
50 neuroleptic malignant syndrome 10.0

Comorbidity relations with Serotonin Syndrome via Phenotypic Disease Network (PDN):


Intestinal Obstruction

Graphical network of the top 20 diseases related to Serotonin Syndrome:



Diseases related to Serotonin Syndrome

Symptoms & Phenotypes for Serotonin Syndrome

GenomeRNAi Phenotypes related to Serotonin Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.1 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Serotonin Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 SST HTR3A SSTR1 TAC1 MAOA MAOB
2 endocrine/exocrine gland MP:0005379 9.81 HTR2A HTR3A MEN1 NOTCH1 CHGA OXT
3 homeostasis/metabolism MP:0005376 9.8 HTR3A SSTR1 MAOA MAOB MEN1 NOTCH1
4 nervous system MP:0003631 9.4 SST HTR3A SSTR1 MAOA MAOB MEN1

Drugs & Therapeutics for Serotonin Syndrome

Drugs for Serotonin Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 500)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
3
Metformin Approved Phase 4,Phase 2 657-24-9 14219 4091
4
Haloperidol Approved Phase 4,Phase 3,Phase 2,Phase 1 52-86-8 3559
5
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 132539-06-1 4585
6
Clozapine Approved Phase 4,Phase 3,Phase 2,Phase 1 5786-21-0 2818
7
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 106266-06-2 5073
8
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 54910-89-3 3386
9
Ziprasidone Approved Phase 4,Phase 3,Phase 2 146939-27-7 60854
10
Ondansetron Approved Phase 4,Phase 3,Phase 1,Phase 2 99614-02-5 4595
11
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1 59729-33-8 2771
12
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
13
Sertraline Approved Phase 4,Phase 3,Phase 1,Phase 2 79617-96-2 68617
14 Zotepine Approved Phase 4 26615-21-4
15
Milnacipran Approved Phase 4,Phase 3,Phase 2,Phase 1 92623-85-3 65833
16
Perphenazine Approved Phase 4,Phase 2,Phase 3,Phase 1 58-39-9 4748
17
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2 129722-12-9 60795
18
Zolpidem Approved Phase 4 82626-48-0 5732
19
Benzocaine Approved Phase 4,Phase 2 1994-09-7, 94-09-7 2337
20
Etomidate Approved Phase 4 33125-97-2 36339 667484
21
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 1,Phase 2 148553-50-8 5486971
22 Ramosetron Approved Phase 4,Phase 3,Phase 2,Early Phase 1 132036-88-5
23
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
24
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
25
Chlorpromazine Approved, Vet_approved Phase 4 50-53-3 2726
26
Valproic Acid Approved, Investigational Phase 4,Phase 3 99-66-1 3121
27
Trifluoperazine Approved Phase 4 117-89-5 5566
28
Histamine Approved, Investigational Phase 4,Phase 2,Phase 1 75614-87-8, 51-45-6 774
29
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
30
Sumatriptan Approved, Investigational Phase 4,Phase 3 103628-46-2 5358
31
Naproxen Approved, Vet_approved Phase 4,Phase 3 22204-53-1 1302 156391
32
Fluvoxamine Approved, Investigational Phase 4,Phase 3 54739-18-3 3404 5324346
33
Pimozide Approved Phase 4 2062-78-4 16362
34
Pramlintide Approved, Investigational Phase 4 151126-32-8
35
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
36
Sulpiride Approved Phase 4 15676-16-1 5355
37
Ropinirole Approved, Investigational Phase 4,Phase 3 91374-20-8, 91374-21-9 5095 497540
38
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 61869-08-7 43815
39
Clomipramine Approved, Vet_approved Phase 4 303-49-1 2801
40
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
41
Lorazepam Approved Phase 4,Phase 1 846-49-1 3958
42
Modafinil Approved, Investigational Phase 4,Phase 1,Phase 2 68693-11-8 4236
43
Molindone Approved Phase 4 7416-34-4 23897
44
Trazodone Approved, Investigational Phase 4,Phase 1,Early Phase 1 19794-93-5 5533
45
Eletriptan Approved, Investigational Phase 4 143322-58-1 77993
46
Frovatriptan Approved, Investigational Phase 4 158747-02-5 77992
47
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
48
Armodafinil Approved, Investigational Phase 4,Phase 1,Phase 2 112111-43-0
49
Dinoprostone Approved Phase 4 363-24-6 5280360
50
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616

Interventional clinical trials:

(show top 50) (show all 550)
id Name Status NCT ID Phase
1 Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors Unknown status NCT00454376 Phase 4
2 DECARD: Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome Unknown status NCT00140257 Phase 4
3 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
4 Study of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia, and Mixed Vascular and Alzheimer’s Dementia Unknown status NCT00229333 Phase 4
5 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4
6 Risperidone and Zotepine in the Treatment of Delirium Unknown status NCT00622011 Phase 4
7 Effect of Ramosetron on Bowel Motility After Colorectal Resection Unknown status NCT01427127 Phase 4
8 Electroconvulsive Therapy (ECT) in Patients With Super Refractory Schizophrenia Unknown status NCT02049021 Phase 4
9 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4
10 Tandospirone Combined With Atypical Antipsychotic Drugs in Schizophrenia Unknown status NCT02040883 Phase 4
11 Randomized Evaluation of the Effectiveness of Clozapine and Aripiprazole Versus Clozapine and Haloperidol in the Treatment of Schizophrenia Unknown status NCT00395915 Phase 4
12 Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-Compulsive Disorder Patients Completed NCT00564564 Phase 4
13 Using Drug Augmentation to Treat Obsessive Compulsive Disorder Patients Who Did Not Respond to Previous Treatment Completed NCT00466609 Phase 4
14 Manipulation of Visceral Hypersensitivity With Probiotic Bacteria in Irritable Bowel Syndrome Completed NCT01139736 Phase 4
15 Safety and Efficacy of Aripiprazole and Ziprasidone Among Schizophrenic Patients With Metabolic Syndrome Completed NCT01714011 Phase 4
16 Serotonin and the Upper Airway in Obstructive Sleep Apnea Completed NCT00100464 Phase 4
17 Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D) Completed NCT00745004 Phase 4
18 A Placebo-Controlled Study to Investigate the Onset of Action of Paroxetine in Premenstrual Dysphoria Completed NCT00516113 Phase 4
19 Treating Sexual Dysfunction From Selective Serotonin Reuptake Inhibitor (SSRI) Medication: a Study Comparing Requip CR to Placebo Completed NCT00334048 Phase 4
20 The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder Completed NCT00678574 Phase 4
21 Lansoprazole Versus Mosapride for Functional Dyspepsia Completed NCT00663897 Phase 4
22 Comparison of Three Different Prophylactic Treatments of Postoperative Nausea and Vomiting (PONV) in Children Completed NCT01434017 Phase 4
23 Mesalazine for the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D) Completed NCT01316718 Phase 4
24 Study on the Effect of Granisetron on Myofascial Pain in the Orofacial Muscles Completed NCT02230371 Phase 4
25 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4
26 Efficacy of Tegaserod in Relieving the Symptoms of Female Patients With Irritable Bowel Syndrome (IBS), Excluding Those With Predominant Diarrhea IBS Completed NCT00142987 Phase 4
27 Paroxetine - Controlled Release in the Treatment of Irritable Bowel Syndrome (IBS) Completed NCT00610909 Phase 4
28 Validation of Surrogate Measures in Irritable Bowel Syndrome (IBS) Completed NCT00693732 Phase 4
29 Escitalopram Trial for Irritable Bowel Syndrome (IBS) Patients With Panic Disorder Completed NCT01551225 Phase 4
30 A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients Completed NCT01225237 Phase 4
31 A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4
32 Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome Completed NCT00610610 Phase 4
33 Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS) Completed NCT00318773 Phase 4
34 The Effect of Cipralex on Quality of Life, Adrenal Activity Glucose Metabolism, Physical and Mental Health in PCOS Completed NCT01961180 Phase 4
35 Escitalopram in Depressive Patients With Acute Coronary Artery Syndrome Completed NCT00419471 Phase 4
36 An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome Completed NCT00401258 Phase 4
37 An Open Label Trial of Duloxetine in the Treatment of Irritable Bowel Syndrome and Comorbid Generalized Anxiety Disorder Completed NCT00961298 Phase 4
38 Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression Completed NCT01754493 Phase 4
39 Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes Completed NCT00338949 Phase 4
40 Effect of Milnacipran on Pain in Fibromyalgia Completed NCT01288807 Phase 4
41 Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism Completed NCT01337700 Phase 4
42 Study Evaluating Venlafaxine Extended Release in Elderly Depressed Patients Completed NCT00247429 Phase 4
43 Symptomatic Remission and Social Function in Participants Treated With Paliperidone Extended Release (ER) Completed NCT01577186 Phase 4
44 Pragmatic RCT Comparing Aripiprazole, Olanzapine and Haloperidol in the Treatment of Schizophrenia Completed NCT01052389 Phase 4
45 Adjunctive Low-dose Metformin in Patients With Schizophrenia and Metabolic Abnormalities Completed NCT02751307 Phase 4
46 Functional Change and Efficacy of Duloxetine in Patients With Co-Morbid Depression & Soft Tissue Discomfort Syndrome Completed NCT01035073 Phase 4
47 Different Safety Profile of Risperidone and Paliperidone Extended-release Completed NCT01284959 Phase 4
48 Paliperidone Extended Release in Schizophrenia Participants With Duration of Illness Less Than 10 Years Completed NCT01362439 Phase 4
49 Tolerability, Safety and Efficacy of Flexibly Dosed Paliperidone ER in Patients With Schizophrenia Completed NCT01724359 Phase 4
50 An Efficacy, Safety And Tolerability Study of Flexibly Dosed Paliperidone Extended-Release (ER) in Participants With Schizophrenia Completed NCT00757705 Phase 4

Search NIH Clinical Center for Serotonin Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Serotonin Syndrome

Anatomical Context for Serotonin Syndrome

MalaCards organs/tissues related to Serotonin Syndrome:

39
Brain, Spinal Cord, Hypothalamus, Bone, Heart, Bone Marrow, Liver

Publications for Serotonin Syndrome

Articles related to Serotonin Syndrome:

(show top 50) (show all 576)
id Title Authors Year
1
Cervical Spinal Cord Stimulation with Concomitant Serotonin Norepinephrine Reuptake Inhibitor Therapy Leading to the Serotonin Syndrome. ( 28057811 )
2017
2
Methylene blue-induced serotonin syndrome presenting with ocular clonus and failure of emergence from general anesthesia. ( 26943644 )
2016
3
Methylene Blue Causing Serotonin Syndrome Following Cystocele Repair. ( 27617215 )
2016
4
Tramadol Pill Alone May Cause Serotonin Syndrome. ( 26996488 )
2016
5
Serotonin syndrome: Preventing, recognizing, and treating it. ( 27824534 )
2016
6
New Insights on Different Response of MDMA-Elicited Serotonin Syndrome to Systemic and Intracranial Administrations in the Rat Brain. ( 27192423 )
2016
7
Reply to Wolvetang et al: "Serotonin Syndrome After Methylene Blue Administration During Cardiac Surgery: A Case Report and Review". ( 27554232 )
2016
8
Serotonin Syndrome Following an Uncomplicated Orthopedic Surgery in a Patient With Post-Traumatic Stress Disorder. ( 27612381 )
2016
9
Overlapping of Serotonin Syndrome with Neuroleptic Malignant Syndrome due to Linezolid-Fluoxetine and Olanzapine-Metoclopramide Interactions: A Case Report of Two Serious Adverse Drug Effects Caused by Medication Reconciliation Failure on Hospital Admission. ( 27433163 )
2016
10
Conundrums in neurology: diagnosing serotonin syndrome - a meta-analysis of cases. ( 27406219 )
2016
11
Serotonin syndrome presenting as surgical emergency: A report of two cases. ( 27076715 )
2016
12
Serotonin Syndrome With Fluoxetine: Two Case Reports. ( 27999518 )
2016
13
Management of Serotonin Syndrome and Neuroleptic Malignant Syndrome. ( 27469512 )
2016
14
Perioperative Diagnosis and Treatment of Serotonin Syndrome Following Administration of Methylene Blue. ( 27210537 )
2016
15
Assessment and management of serotonin syndrome in a simulated patient study of Australian community pharmacies. ( 27382424 )
2016
16
Electroconvulsive Therapy Induces Transient Sensitivity for a Serotonin Syndrome: A Case Report. ( 27458743 )
2016
17
A Case Report of Probable Paliperidone ER-Induced Serotonin Syndrome in a 17-Year-Old Taiwanese Female With New Onset Psychosis. ( 26945397 )
2016
18
Linezolid and Rasagiline - A culprit for serotonin syndrome. ( 26997732 )
2016
19
Serotonin syndrome induced by a combination of venlafaxine and clomipramine. A case report. ( 27644101 )
2016
20
Serotonin syndrome presenting as pulmonary edema. ( 26997733 )
2016
21
Probable Tapentadol-Associated Serotonin Syndrome After Overdose. ( 27303080 )
2016
22
Probable Serotonin Syndrome and Withdrawal Symptoms Caused by Milnacipran. ( 27904101 )
2016
23
No laughing matter: nitrous oxide triggers serotonin syndrome in an anxious adolescent. ( 27290939 )
2016
24
Serotonin Syndrome after Clomipramine Overdose in a Child. ( 27776393 )
2016
25
Serotonin Syndrome Resulting From Acute Decompensation of Nonalcoholic Steatohepatitis Cirrhosis in a Patient Chronically Treated With Citalopram and Tramadol. ( 27838198 )
2016
26
Tramadol-Induced Hypomania and Serotonin Syndrome. ( 28002658 )
2016
27
Serotonin Syndrome Following Methylene Blue Administration for Vasoplegic Syndrome. ( 26934199 )
2016
28
Possible serotonin syndrome with carbidopa-levodopa and linezolid. ( 26813986 )
2016
29
A Case of Fatal Human Rabies Caused by Tricolored Bat-Associated Rabies Virus Presenting Like Serotonin Syndrome. ( 27001756 )
2016
30
Serotonin Syndrome: Prophylactic Treatment With Cyproheptadine. ( 27828700 )
2016
31
Combination of paroxetine and rasagiline induces serotonin syndrome in a parkinsonian patient. ( 27838092 )
2016
32
Serotonin syndrome, rhabdomyolysis and convulsion associated with drug interaction between venlafaxine and amoxicillin/clavulanic acid. ( 27644102 )
2016
33
Cyproheptadine-dependent chronic serotonin syndrome. ( 27841211 )
2016
34
The impact of pharmacists' input to reduce serotonin syndrome drug interactions in an Australian hospital. ( 27552535 )
2016
35
Anesthetic management of a known case of serotonin syndrome undergoing renal transplant. ( 27625499 )
2016
36
Serotonin syndrome presenting as febrile encephalopathy with CSF pleocytosis: a report of three cases. ( 27325387 )
2016
37
Ocular Flutter in the Serotonin Syndrome. ( 27806222 )
2016
38
A Case of Serotonin Syndrome Following Cyproheptadine Withdrawal. ( 26644949 )
2015
39
Serotonin Syndrome in Pregnancy. ( 26264799 )
2015
40
Serotonin Syndrome: The Potential for a Severe Reaction Between Common Perioperative Medications and Selective Serotonin Reuptake Inhibitors. ( 26528701 )
2015
41
Combination of Escitalopram and Rasagiline Induced Serotonin Syndrome: A Case Report and Review Literature. ( 27004312 )
2015
42
Serotonin syndrome induced by the readministration of escitalopram after a short-term interruption in an elderly woman with depression: a case report. ( 26491328 )
2015
43
Mild serotonin syndrome: A report of 12 cases. ( 26019424 )
2015
44
Psychiatric Emergencies for Clinicians: Emergency Department Management of Serotonin Syndrome. ( 26454578 )
2015
45
Serotonin syndrome following methylene blue administration during cardiothoracic surgery. ( 25613051 )
2015
46
A Case of an Older Adult Patient and Drugs Associated with Serotonin Syndrome. ( 26260641 )
2015
47
Effects of fentanyl on serotonin syndrome-like behaviors in rats. ( 26499475 )
2015
48
A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats. ( 25596946 )
2015
49
Serotonin syndrome with a combination of aripiprazole and fluoxetine: a case report. ( 26240751 )
2015
50
A case of the serotonin syndrome secondary to phenelzine monotherapy at therapeutic dosing. ( 25861278 )
2015

Variations for Serotonin Syndrome

Expression for Serotonin Syndrome

Search GEO for disease gene expression data for Serotonin Syndrome.

Pathways for Serotonin Syndrome

Pathways related to Serotonin Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 GHRH HTR1A HTR2A OXT PYY SST
2 11.55 CYP2D6 HTR1A HTR2A HTR3A MAOA MAOB
3 11.44 HTR1A HTR2A HTR3A MAOA SLC6A4 SST
4
Show member pathways
11.11 CYP2D6 CYP3A4 SLC6A4
5 11 HTR1A HTR2A HTR3A MAOA SLC6A4
6 10.55 MAOA MAOB
7
Show member pathways
10.51 MAOA MAOB
8
Show member pathways
10.44 MAOA MAOB

GO Terms for Serotonin Syndrome

Cellular components related to Serotonin Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CHGA GAST GHRH IFNA2 OXT PYY
2 extracellular region GO:0005576 9.32 CGB3 CHGA GAST GHRH IFNA2 NOTCH1

Biological processes related to Serotonin Syndrome according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.79 PYY SSTR1 TAC1
2 response to nutrient GO:0007584 9.76 SLC6A4 SST SSTR1
3 digestion GO:0007586 9.7 PYY SST SSTR1
4 memory GO:0007613 9.69 HTR2A OXT SLC6A4
5 vasoconstriction GO:0042310 9.62 HTR1A SLC6A4
6 positive regulation of ossification GO:0045778 9.61 OXT TAC1
7 negative regulation of cell-substrate adhesion GO:0010812 9.6 MEN1 NOTCH1
8 positive regulation of renal sodium excretion GO:0035815 9.59 OXT TAC1
9 sleep GO:0030431 9.58 HTR2A OXT
10 behavior GO:0007610 9.57 HTR1A HTR2A
11 neurotransmitter catabolic process GO:0042135 9.56 MAOA MAOB
12 regulation of behavior GO:0050795 9.55 HTR1A HTR2A
13 oxidative demethylation GO:0070989 9.54 CYP2D6 CYP3A4
14 response to steroid hormone GO:0048545 9.5 MAOB OXT SST
15 dopamine catabolic process GO:0042420 9.49 MAOA MAOB
16 sperm ejaculation GO:0042713 9.48 OXT SLC6A4
17 regulation of hormone secretion GO:0046883 9.46 HTR1A HTR2A
18 drug catabolic process GO:0042737 9.43 CYP2D6 CYP3A4
19 heterocycle metabolic process GO:0046483 9.4 CYP2D6 CYP3A4
20 monoterpenoid metabolic process GO:0016098 9.37 CYP2D6 CYP3A4
21 response to food GO:0032094 9.33 GAST GHRH OXT
22 alkaloid catabolic process GO:0009822 9.26 CYP2D6 CYP3A4
23 cell-cell signaling GO:0007267 9.17 CGB3 GHRH IFNA2 PYY SST SSTR1
24 serotonin receptor signaling pathway GO:0007210 9.13 HTR1A HTR2A HTR3A

Molecular functions related to Serotonin Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled serotonin receptor activity GO:0004993 9.33 HTR1A HTR2A HTR3A
2 primary amine oxidase activity GO:0008131 9.26 MAOA MAOB
3 serotonin binding GO:0051378 9.13 HTR1A HTR2A HTR3A
4 hormone activity GO:0005179 9.02 CGB3 GAST OXT PYY SST

Sources for Serotonin Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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