MCID: SRT004
MIFTS: 58

Serotonin Syndrome malady

Neuronal diseases, Rare diseases categories
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Summaries for Serotonin Syndrome

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Wikipedia:65 Serotonin syndrome is a potential symptom of any number of life-threatening drug interaction which may... more...

MalaCards based summary: Serotonin Syndrome, also known as serotonergic syndrome, is related to neuroleptic malignant syndrome and parkinson's disease. An important gene associated with Serotonin Syndrome is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Codeine and Morphine Pathway, Pharmacokinetics and Gefitinib Pathway, Pharmacokinetics. The drug interferon alfa-2b and the compounds mcpp and buspirone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and bone, and related mouse phenotypes are digestive/alimentary and renal/urinary system.

Aliases & Classifications for Serotonin Syndrome

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Sources:
48Orphanet, 62UMLS, 35MESH via Orphanet, 63UMLS via Orphanet
See all sources

Serotonin Syndrome, Aliases & Descriptions:

Name: Serotonin Syndrome 48 62
Serotonergic Syndrome 48
Serotonin Toxidrome 48
 
Serotonin Toxicity 48
Serotonin Storm 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
serotonin syndrome:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

MESH via Orphanet35 D020230
UMLS via Orphanet63 C0699828

Related Diseases for Serotonin Syndrome

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Diseases related to Serotonin Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1neuroleptic malignant syndrome31.0PIK3C2A, CYP2D6, HTR1A
2parkinson's disease30.3CYP2D6, HTR1A, MAOA, TAC1
3fibromyalgia30.3HTR2A, SLC6A4, TAC1, HTR3A
4acute myocardial infarction29.9PIK3C2A, HTR2A, HTR3A, SLC6A4
5myocardial infarction29.8PIK3C2A, HTR2A, HTR3A, SLC6A4
6migraine29.7CYP2D6, HTR2A, HTR3A, HTR1A, MAOA, TAC1
7obsessive-compulsive disorder29.7OXT, HTR2A, HTR3A, HTR1A, MAOA, SLC6A4
8melancholia10.5MAOA
9apudoma10.5SST
10gigantism10.5SST
11motion sickness10.5HTR3A, HTR1A
12duodenogastric reflux10.5GAST
13dysthymic disorder10.5HTR2A, MAOA
14pernicious anemia10.5GAST
15heart valve disease10.4HTR2A, HTR3A
16alcoholic psychosis10.4SLC6A4
17amnestic disorder10.4HTR3A, HTR1A
18cushing's syndrome10.4SST, GHRH
19agoraphobia10.4HTR1A, MAOA
20peripheral vascular disease10.4TAC1
21premature ejaculation10.4HTR1A, SLC6A4
22dumping syndrome10.4PYY, SST
23pituitary gland disease10.4SST, MEN1
24generalized anxiety disorder10.4HTR1A, SLC6A4
25bipolar disorder10.3HTR1A, SLC6A4
26acinar cell carcinoma10.3CHGA, GAST
27hyperprolactinemia10.3SST, GHRH, CGB
28endogenous depression10.3HTR1A, SLC6A4
29pancreatic islet cell tumors10.3SST, GAST
30portal hypertension10.3SST, HTR2A, MAOA
31hyperthyroidism10.3CGB, GHRH, SST
32cocaine abuse10.3HTR3A, SLC6A4
33neuroendocrine tumor10.3CHGA, SST, GHRH
34double outlet right ventricle10.3PYY, SLC6A4
35anxiety disorder10.3HTR3A, MAOA, SLC6A4
36personality disorder10.3MAOA, SLC6A4
37panic disorder10.3SLC6A4, HTR1A, HTR3A
38hyperinsulinemic hypoglycemia10.3SST, GAST
39gastroparesis10.3HTR3A, GAST
40factor vii deficiency10.3IFNA2, SST, CHGA
41chronic fatigue syndrome10.3HTR1A, MAOA, SLC6A4
42drug dependence10.3MAOA, SLC6A4
43primary hyperparathyroidism10.3CHGA, MEN1, GAST
44seasonal affective disorder10.3HTR2A, HTR1A, SLC6A4
45multiple endocrine neoplasia10.3CHGA, MEN1, GAST
46hyperparathyroidism10.3CHGA, MEN1, GAST
47antisocial personality disorder10.2HTR2A, MAOA, SLC6A4
48hypercalcemia10.2GAST, MEN1, CHGA
49diabetes insipidus10.2OXT, GHRH
50attention deficit hyperactivity disorder10.2SLC6A4, MAOA, HTR2A

Graphical network of the top 20 diseases related to Serotonin Syndrome:



Diseases related to serotonin syndrome

Symptoms for Serotonin Syndrome

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Drugs & Therapeutics for Serotonin Syndrome

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Drug clinical trials:

Search ClinicalTrials for Serotonin Syndrome

Search NIH Clinical Center for Serotonin Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Serotonin Syndrome

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Anatomical Context for Serotonin Syndrome

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MalaCards organs/tissues related to Serotonin Syndrome:

32
Brain, Bone marrow, Bone, Spinal cord, Heart, Hypothalamus

Animal Models for Serotonin Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Serotonin Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.9NOTCH1, GAST, HTR2A, MEN1, SST, OXT
2MP:00053677.6PIK3C2A, CHGA, OXT, HTR3A, TAC1, NOTCH1
3MP:00053857.4CHGA, OXT, MEN1, HTR1A, MAOA, TAC1
4MP:00053797.3CHGA, OXT, MEN1, HTR2A, HTR3A, GHRH
5MP:00036317.0PYY, OXT, SSTR1, SST, MEN1, HTR3A
6MP:00053786.9OXT, CHGA, PIK3C2A, PYY, SST, MEN1
7MP:00053866.9SST, SSTR1, OXT, PYY, HTR2A, HTR3A
8MP:00053765.6SLC6A4, PYY, PIK3C2A, CHGA, OXT, SSTR1

Publications for Serotonin Syndrome

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Articles related to Serotonin Syndrome:

(show top 50)    (show all 491)
idTitleAuthorsYear
1
Linezolid is associated with serotonin syndrome in a patient receiving amitriptyline, and fentanyl: a case report and review of the literature. (23533900)
2013
2
Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models. (22985508)
2012
3
Comment: Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. (22414792)
2012
4
Serotonin syndrome-muscle rigidity and confusion in the older adult. (22079646)
2012
5
Suspected serotonin syndrome in a patient being treated with methylene blue for ifosfamide encephalopathy. (22235061)
2012
6
A venlafaxine and mirtazapine-induced serotonin syndrome confirmed by de- and re-challenge. (22752315)
2012
7
Lethal serotonin syndrome after methylone and butylone ingestion. (22160789)
2012
8
Serotonin syndrome secondary to tramadol and citalopram. (21414947)
2011
9
Serotonin syndrome: an unusual cause of acute confusion and fever in the elderly. (22111101)
2011
10
Rasagiline-induced serotonin syndrome. (21370275)
2011
11
The FDA alert on serotonin syndrome with use of triptans combined with selective serotonin reuptake inhibitors or selective serotonin-norepinephrine reuptake inhibitors: American Headache Society position paper. (20618823)
2010
12
Venlafaxine-associated serotonin syndrome causing severe rhabdomyolysis and acute renal failure in a patient with idiopathic Parkinson disease. (20814334)
2010
13
Serotonin syndrome associated with linezolid use: a case report]. (20013432)
2009
14
Serotonin syndrome induced by duloxetine. (19452666)
2009
15
Serotonin syndrome associated with triptan monotherapy. (18480219)
2008
16
Serotonin syndrome in the oral and maxillofacial surgery office: a review of the literature and report of a case. (18718407)
2008
17
Deadly serotonin syndrome. (18783034)
2008
18
Drug-induced serotonin syndrome: a review. (18759711)
2008
19
Treatment of acute mania with ambient air anionization: variants of climactic heat stress and serotonin syndrome. (17451018)
2007
20
Neuroleptic malignant syndrome and serotonin syndrome. (17645916)
2007
21
Serotonin syndrome. (17384366)
2007
22
First time, low dose citalopram use-related serotonin syndrome. (18213744)
2007
23
Venlafaxine-associated serotonin syndrome and manic episode in a geriatric depressive patient. (16472373)
2006
24
Citalopram-induced serotonin syndrome: a case report. (16089311)
2005
25
Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. (14970364)
2004
26
Mirtazapine-induced serotonin syndrome. (12671522)
2003
27
Comment: combination risperidone and SSRI-induced serotonin syndrome. (14519058)
2003
28
Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. (12830431)
2003
29
Serotonin syndrome produced by a combination of venlafaxine and mirtazapine. (12478883)
2002
30
Serotonin syndrome - 'potential' role of the CYP2D6 genetic polymorphism in Asians. (12057035)
2002
31
Serotonin syndrome in HIV-infected individuals receiving antiretroviral therapy and fluoxetine. (11426073)
2001
32
Serotonin syndrome preceding pseudoseizures in an adolescent. (11739917)
2001
33
Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine. (11215836)
2001
34
Serotonin syndrome induced by fluvoxamine and mirtazapine. (11675850)
2001
35
Comment: serotonin syndrome and 5-HT2A antagonism. (11573872)
2001
36
Serotonin syndrome in a teenager following overdose of dothiepine hydrochloride. (10214923)
1998
37
Serotonin syndrome: history and risk. (9794145)
1998
38
Venlafaxine induced serotonin syndrome occurring after abstinence from phenelzine for more than two weeks. (9120894)
1997
39
The serotonin syndrome. (9255139)
1997
40
Selective serotonin reuptake inhibitor-induced serotonin syndrome: review. (9169967)
1997
41
Serotonin syndrome due to an overdose of moclobemide and clomipramine. A potentially life-threatening association. (9037653)
1997
42
Serotonin syndrome after lithium add-on medication to paroxetine. (9211572)
1997
43
Ssri-related toxic serotonin syndrome: improvement by discontinuation of treatment and propranolol. (19698545)
1997
44
Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome. (8777769)
1996
45
Serotonin syndrome complicating migraine pharmacotherapy. (8869767)
1996
46
Serotonin syndrome in the elderly after antidepressive monotherapy. (8748434)
1995
47
Serotonin syndrome--a potentially fatal complication of antidepressant therapy. (7476638)
1995
48
Serotonin syndrome produced by a combination of fluoxetine and lithium. (8379573)
1993
49
Serotonin syndrome. (1636815)
1992
50
The serotonin syndrome. (2048681)
1991

Variations for Serotonin Syndrome

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Expression for genes affiliated with Serotonin Syndrome

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Expression patterns in normal tissues for genes affiliated with Serotonin Syndrome

Search GEO for disease gene expression data for Serotonin Syndrome.

Pathways for genes affiliated with Serotonin Syndrome

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Pathways related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Codeine and morphine metabolism37
9.8CYP2D6, CYP3A4
2
Show member pathways
9.8CYP3A4, CYP2D6
3
Show member pathways
9.5MAOA, CYP3A4, CYP2D6
4
Show member pathways
9.5MAOA, CYP3A4, CYP2D6
5
Show member pathways
9.3SLC6A4, CYP3A4, CYP2D6
69.2HTR2A, HTR3A, HTR1A, MAOA, SLC6A4
7
Show member pathways
8.9CYP2D6, HTR2A, HTR3A, HTR1A, MAOA, SLC6A4
8
Show member pathways
8.3OXT, HTR2A, GAST, TAC1
97.9SLC6A4, SSTR1, SST, HTR2A, HTR3A, HTR1A
10
Show member pathways
7.5PYY, OXT, SSTR1, SST, HTR2A, HTR1A
11
Show member pathways
6.3PYY, OXT, SSTR1, SST, MEN1, HTR2A

Compounds for genes affiliated with Serotonin Syndrome

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Compounds related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 460)
idCompoundScoreTop Affiliating Genes
1mcpp449.5SLC6A4, HTR1A, CYP2D6, HTR2A, HTR3A
2buspirone44 28 1111.4HTR3A, CYP2D6, CYP3A4, HTR1A, HTR2A
3pindolol44 28 1111.4CYP2D6, HTR3A, SLC6A4, HTR1A, HTR2A
4fenfluramine44 28 1111.3SLC6A4, GHRH, HTR1A, HTR3A, HTR2A, CYP2D6
55-hydroxytryptophan449.3CHGA, HTR2A, HTR3A, HTR1A, SLC6A4, SST
6paroxetine44 50 28 1112.2SLC6A4, HTR1A, HTR3A, HTR2A, MAOA, CYP2D6
7trazodone44 28 1111.1HTR1A, CYP2D6, CYP3A4, SLC6A4, HTR2A
8granisetron50 44 1111.1TAC1, CYP2D6, CYP3A4, HTR2A, HTR3A
9nefazodone44 50 1111.1HTR2A, CYP2D6, CYP3A4, SLC6A4, HTR1A, HTR3A
10sertraline44 28 50 24 1113.1HTR3A, CYP2D6, CYP3A4, HTR1A, MAOA, SLC6A4
11venlafaxine44 50 24 1112.1CYP2D6, HTR1A, CYP3A4, HTR2A, HTR3A, SLC6A4
12trimipramine44 50 1111.0HTR2A, SLC6A4, HTR1A, CYP3A4, CYP2D6
13quetiapine44 50 28 24 1113.0CYP3A4, HTR1A, SLC6A4, HTR2A, CYP2D6, HTR3A
14fluvoxamine44 50 1111.0HTR2A, CYP2D6, CYP3A4, HTR3A, HTR1A, MAOA
15mianserin44 28 1110.9CYP3A4, HTR2A, HTR3A, HTR1A, MAOA, SLC6A4
16clomipramine44 50 1110.9MAOA, SLC6A4, HTR1A, CYP2D6, CYP3A4, HTR2A
17amitriptyline44 28 50 1111.9CYP3A4, HTR2A, HTR3A, CYP2D6, HTR1A, MAOA
18citalopram44 50 24 1111.9CYP3A4, HTR2A, HTR3A, MAOA, HTR1A, SLC6A4
19desipramine44 50 1110.9SLC6A4, HTR2A, HTR1A, MAOA, CYP3A4, CYP2D6
20risperidone44 50 28 61 24 1113.9HTR1A, SLC6A4, CYP2D6, CYP3A4, HTR3A, HTR2A
21imipramine44 28 50 24 1112.9SLC6A4, CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A
225-hydroxyindoleacetic acid44 249.8CHGA, SST, MAOA, GAST, SLC6A4, HTR3A
23escitalopram44 50 24 1111.8SLC6A4, HTR1A, HTR2A, CYP3A4, CYP2D6
24bromocriptine44 28 1110.8HTR1A, GHRH, HTR2A, SST, PIK3C2A, CYP3A4
25levodopa44 119.7TAC1, CHGA, HTR1A, MAOA, GHRH, SST
26yohimbine44 2 28 1111.7PYY, CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A
27mirtazapine44 50 1110.6HTR3A, HTR2A, SLC6A4, CYP2D6, CYP3A4
28omeprazole44 50 28 24 1112.6SST, CHGA, CYP3A4, CYP2D6, GAST, PYY
29amine448.5CYP2D6, SLC6A4, MAOA, PYY, CHGA, HTR3A
30amphetamine44 50 1110.5SST, TAC1, SLC6A4, CYP2D6, MAOA, PYY
31octreotide44 61 28 1111.4GAST, GHRH, IFNA2, SSTR1, SST, PYY
32clonidine44 50 28 1111.2SLC6A4, TAC1, GHRH, SST, CHGA, CYP3A4
33ondansetron50 44 24 1111.0CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A, SLC6A4
345-hydroxytryptamine447.7SLC6A4, TAC1, GAST, MAOA, HTR1A, HTR3A
35gnrh447.6SST, CHGA, OXT, PYY, GHRH, CGB
36propranolol44 28 50 24 1111.6CYP2D6, TAC1, CYP3A4, CHGA, SST, HTR3A
37fluoxetine44 50 28 1110.6SLC6A4, TAC1, CYP2D6, HTR3A, HTR2A, OXT
38haloperidol44 50 28 2 1111.6PYY, PIK3C2A, CYP2D6, CYP3A4, CHGA, HTR2A
39acetylcholine44 50 28 24 1111.6PYY, TAC1, GAST, HTR1A, HTR3A, SST
40thyroxine44 248.5PIK3C2A, OXT, IFNA2, SST, GHRH, GAST
41acth447.4HTR1A, GAST, GHRH, PYY, SST, CHGA
42nifedipine44 28 50 1110.4GAST, CYP2D6, CHGA, OXT, SST, GHRH
43gaba447.2SLC6A4, OXT, CHGA, PYY, HTR3A, MAOA
44nicotine44 28 50 1110.2CHGA, TAC1, GAST, SLC6A4, OXT, CYP2D6
45dexamethasone44 50 28 1110.1HTR3A, GHRH, MAOA, GAST, TAC1, SST
46epinephrine44 24 118.6SLC6A4, TAC1, GAST, IFNA2, SST, OXT
47estrogen446.5OXT, SLC6A4, NOTCH1, CHGA, TAC1, MEN1
48norepinephrine44 24 118.1SLC6A4, TAC1, GAST, MAOA, GHRH, HTR1A
49testosterone44 61 24 119.1OXT, CHGA, CYP3A4, CYP2D6, PIK3C2A, SST
50dopamine44 28 24 118.6HTR1A, HTR3A, HTR2A, SST, SSTR1, OXT

GO Terms for genes affiliated with Serotonin Syndrome

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Cellular components related to Serotonin Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.9SST, HTR2A, HTR3A, TAC1
2extracellular spaceGO:0056158.1TAC1, GHRH, IFNA2, SST, OXT, PYY
3extracellular regionGO:0055766.6CGB, PYY, CHGA, OXT, SST, IFNA2

Biological processes related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.4HTR1A, HTR2A
2serotonin receptor signaling pathwayGO:00721010.2HTR1A, HTR3A, HTR2A
3regulation of behaviorGO:05079510.2HTR2A, HTR1A
4alkaloid catabolic processGO:00982210.1CYP3A4, CYP2D6
5drug catabolic processGO:04273710.1CYP3A4, CYP2D6
6heterocycle metabolic processGO:04648310.0CYP2D6, CYP3A4
7negative regulation of organ growthGO:04662110.0MEN1, SLC6A4
8monoterpenoid metabolic processGO:01609810.0CYP2D6, CYP3A4
9oxidative demethylationGO:07098910.0CYP2D6, CYP3A4
10sleepGO:0304319.6HTR2A, OXT
11digestionGO:0075869.6PYY, SSTR1, SST, HTR3A
12vasoconstrictionGO:0423109.6SLC6A4, HTR1A
13response to nutrientGO:0075849.5SLC6A4, SST, SSTR1
14positive regulation of cell proliferationGO:0082849.5NOTCH1, GHRH, HTR1A, HTR2A
15sperm ejaculationGO:0427139.5OXT, SLC6A4
16response to foodGO:0320949.5GHRH, OXT
17synaptic transmissionGO:0072689.3SST, HTR2A, HTR3A, MAOA, TAC1
18memoryGO:0076139.3OXT, HTR2A, SLC6A4
19G-protein coupled receptor signaling pathwayGO:0071869.3GAST, HTR1A, SST, PYY
20positive regulation of ossificationGO:0457789.2TAC1, OXT
21positive regulation of renal sodium excretionGO:0358159.1TAC1, OXT
22negative regulation of cell proliferationGO:0082859.1SSTR1, SST, MEN1, NOTCH1
23cell-cell signalingGO:0072678.6CGB, TAC1, GHRH, IFNA2, SST, SSTR1

Molecular functions related to Serotonin Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.1HTR3A, HTR2A
2serotonin receptor activityGO:0049939.8HTR1A, HTR3A, HTR2A
3hormone activityGO:0051798.8CGB, GAST, SST, PYY

Products for genes affiliated with Serotonin Syndrome

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Sources for Serotonin Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet