MCID: SRT004
MIFTS: 44

Serotonin Syndrome malady

Neuronal diseases, Cancer diseases categories

Summaries for Serotonin Syndrome

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Serotonin syndrome is a potentially life-threatening drug reaction that may occur following therapeutic... more...

MalaCards: Serotonin Syndrome, also known as malignant carcinoid syndrome, is related to neuroleptic malignant syndrome and duodenitis. An important gene associated with Serotonin Syndrome is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Codeine and morphine metabolism and Citalopram Pathway, Pharmacokinetics. The drug interferon alfa-2b and the compounds mcpp and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and endocrine/exocrine gland.

Aliases & Classifications for Serotonin Syndrome

About this section
Sources:
48Orphanet, 60UMLS, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
serotonergic syndrome:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

serotonin syndrome 48
malignant carcinoid syndrome 60
serotonergic syndrome 48
serotonin toxidrome 48
serotonin toxicity 48
serotonin storm 48


External Ids:

MESH via Orphanet35 D020230
SNOMED-CT via Orphanet57 371089000
UMLS via Orphanet61 C0699828

Related Diseases for Serotonin Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Serotonin Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1neuroleptic malignant syndrome30.7HTR1A, PIK3C2A, CYP2D6
2duodenitis30.0GAST
3vascular disease30.0PIK3C2A
4parkinson's disease30.0HTR1A, MAOA, CYP2D6, TAC1
5diarrhea30.0TAC1, CYP3A4, SST, CHGA, GAST, HTR3A
6migraine30.0HTR1A, HTR3A, HTR2A, MAOA, CYP2D6, TAC1
7carcinoid syndrome30.0IFNA2, PYY, HTR3A, HTR2A, GAST, NOTCH1
8neuropathy29.8TAC1, PIK3C2A
9hepatitis29.8CYP3A4, CYP2D6, IFNA2
10disseminated intravascular coagulation29.8OXT, PIK3C2A
11myocardial infarction29.8HTR3A, HTR2A, PIK3C2A, SLC6A4
12acute myocardial infarction29.8HTR3A, HTR2A, PIK3C2A, SLC6A4
13obsessive-compulsive disorder29.8HTR2A, HTR3A, HTR1A, OXT, MAOA, SLC6A4
14scleroderma10.3
15cerebritis10.1
16syndromic diarrhea10.1
17secretory diarrhea10.1
18thrombophlebitis10.1
19image syndrome10.1
20adult syndrome10.0
21addison's disease10.0CYP2D6
22von hippel-lindau disease10.0MEN1
23restless legs syndrome10.0HTR3A
24polycystic ovary syndrome10.0GHRH
25merkel cell carcinoma10.0CHGA
26substance abuse10.0SLC6A4
27colon adenocarcinoma10.0CYP3A4
28ganglioneuroma10.0CHGA
29motion sickness10.0HTR1A, HTR3A
30osteomalacia10.0CYP3A4
31melancholia10.0MAOA
32hirschsprung's disease10.0TAC1
33alcoholic psychosis10.0SLC6A4
34arthritis10.0TAC1
35essential hypertension10.0CYP2D6, HTR2A
36esophagitis10.0GAST
37dysthymic disorder10.0HTR2A, MAOA
38narcolepsy10.0HTR2A
39drug dependence10.0MAOA, SLC6A4
40premature ejaculation10.0SLC6A4, HTR1A
41cocaine abuse10.0HTR3A, SLC6A4
42sarcoma10.0CYP3A4, CGB
43bipolar disorder10.0HTR1A, SLC6A4
44polyneuropathy10.0IFNA2
45generalized anxiety disorder10.0HTR1A, SLC6A4
46heart valve disease10.0HTR3A, HTR2A
47kidney cancer10.0IFNA2
48lichen planus10.0IFNA2
49cholestasis10.0CYP3A4, HTR3A
50dyspepsia10.0GAST, HTR3A

Graphical network of the top 20 diseases related to Serotonin Syndrome:



Diseases related to serotonin syndrome

Clinical Features for Serotonin Syndrome

About this section

Drugs & Therapeutics for Serotonin Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Serotonin Syndrome

Drug clinical trials:

Search ClinicalTrials for Serotonin Syndrome

Search NIH Clinical Center for Serotonin Syndrome

Search CenterWatch for Serotonin Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Serotonin Syndrome

About this section

Anatomical Context for Serotonin Syndrome

About this section

Animal Models for Serotonin Syndrome or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Serotonin Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.9PYY, HTR1A, HTR3A, GHRH, SSTR1, OXT
2MP:00053797.8HTR3A, HTR2A, GAST, MEN1, GHRH, OXT
3MP:00053857.4MEN1, CHGA, OXT, MAOA, TAC1, SLC6A4
4MP:00053866.5PYY, HTR1A, HTR3A, HTR2A, SSTR1, SST
5MP:00053765.8NOTCH1, PYY, HTR1A, HTR3A, GAST, PIK3C2A

Publications for Serotonin Syndrome

About this section

Genetic Variations for Serotonin Syndrome

About this section

Expression for genes affiliated with Serotonin Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Serotonin Syndrome

Search GEO for disease gene expression data for Serotonin Syndrome.

Pathways for genes affiliated with Serotonin Syndrome

About this section
Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 29KEGG
See all sources

Pathways related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CYP2D6, CYP3A4
2
Hide members
10.0CYP3A4, CYP2D6
3
Hide members
10.0CYP3A4, CYP2D6
4
Hide members
10.0CYP3A4, CYP2D6
5
Hide members
9.8CYP3A4, CYP2D6, MAOA
6
Hide members
9.4HTR1A, HTR3A, HTR2A, MAOA, SLC6A4
7
Hide members
9.1HTR1A, HTR3A, HTR2A, MAOA, CYP2D6, SLC6A4
8
Hide members
8.3HTR2A, GAST, OXT, TAC1
97.7SLC6A4, HTR1A, HTR3A, HTR2A, SSTR1, SST
10
Hide members
7.3PYY, HTR1A, HTR2A, GHRH, SSTR1, SST
11
Hide members
6.2PYY, HTR1A, HTR2A, GAST, MEN1, GHRH

Compounds for genes affiliated with Serotonin Syndrome

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 425)
idCompoundScoreTop Affiliating Genes
1mcpp449.7SLC6A4, CYP2D6, HTR2A, HTR1A, HTR3A
2estrogen449.7TAC1, SLC6A4
3pindolol44 28 1111.7HTR1A, HTR3A, HTR2A, CYP2D6, SLC6A4
4buspirone44 28 1111.7CYP2D6, HTR2A, CYP3A4, HTR3A, HTR1A
5fenfluramine28 44 1111.5HTR1A, HTR3A, SLC6A4, CYP2D6, GHRH, HTR2A
6escitalopram44 49 11 2412.5CYP2D6, HTR2A, HTR1A, CYP3A4, SLC6A4
7trazodone44 28 1111.5CYP2D6, CYP3A4, SLC6A4, HTR2A, HTR1A
8paroxetine44 49 28 1112.5HTR2A, HTR1A, MAOA, CYP2D6, SLC6A4, HTR3A
9nefazodone44 49 1111.5CYP2D6, SLC6A4, HTR2A, HTR3A, HTR1A, CYP3A4
10sertraline44 28 49 11 2413.5CYP3A4, CYP2D6, MAOA, HTR3A, HTR1A, SLC6A4
11vilazodone44 1110.5HTR1A, CYP3A4, CYP2D6, SLC6A4
12venlafaxine49 44 11 2412.4CYP3A4, HTR1A, HTR3A, HTR2A, CYP2D6, SLC6A4
13trimipramine49 44 1111.4SLC6A4, CYP2D6, HTR2A, CYP3A4, HTR1A
14mianserin28 44 1111.3CYP2D6, MAOA, HTR2A, HTR3A, HTR1A, CYP3A4
15fluvoxamine44 49 1111.3HTR1A, HTR3A, HTR2A, MAOA, CYP2D6, CYP3A4
16clomipramine44 49 1111.3HTR2A, SLC6A4, CYP3A4, CYP2D6, MAOA, HTR3A
175-hydroxytryptophan449.3SLC6A4, SST, HTR2A, HTR3A, HTR1A, CHGA
18iloperidone49 44 28 1112.3HTR3A, CYP3A4, CYP2D6, HTR2A, HTR1A
19amitriptyline44 49 28 1112.3CYP2D6, MAOA, SLC6A4, CYP3A4, HTR1A, HTR3A
208-hydroxy-2-(di-n-propylamino)tetralin449.3HTR2A, SLC6A4, HTR1A, HTR3A
21risperidone28 44 49 59 11 2414.3HTR2A, CYP2D6, SLC6A4, HTR1A, CYP3A4, HTR3A
22citalopram49 44 11 2412.3HTR1A, SLC6A4, CYP3A4, CYP2D6, MAOA, HTR2A
23mirtazapine49 44 1111.3HTR3A, CYP3A4, HTR2A, CYP2D6, SLC6A4
24imipramine44 49 28 11 2413.2HTR1A, HTR3A, SLC6A4, CYP3A4, CYP2D6, MAOA
25desipramine44 49 1111.2HTR1A, MAOA, SLC6A4, CYP2D6, CYP3A4, HTR2A
26gnrh449.1CGB, GAST, CHGA, PYY, GHRH
27granisetron44 1110.1HTR2A, HTR3A, TAC1, CYP3A4, CYP2D6
28yohimbine44 28 2 1112.0CYP3A4, HTR1A, PYY, GAST, HTR2A, HTR3A
295-hydroxyindoleacetic acid44 249.9CHGA, SST, HTR3A, SLC6A4, GAST, MAOA
30omeprazole44 28 49 11 2412.8CYP2D6, SST, CHGA, GAST, PYY, CYP3A4
31bromocriptine28 44 1110.8PIK3C2A, GHRH, CYP3A4, HTR1A, HTR2A, SST
32amine448.7SLC6A4, MAOA, CYP2D6, PYY, HTR3A, GAST
33ondansetron44 49 11 2411.5GAST, CYP2D6, HTR3A, CYP3A4, HTR1A, TAC1
34levodopa44 119.4MAOA, TAC1, CYP2D6, GHRH, SST, HTR1A
35amphetamine44 119.3SST, MAOA, TAC1, SLC6A4, PYY, CYP2D6
36octreotide44 59 28 1111.3GHRH, SSTR1, CHGA, SST, PYY, IFNA2
37clonidine44 28 1110.1CHGA, GHRH, PYY, SST, CYP3A4, TAC1
38acetylcholine44 49 28 11 2411.9CYP2D6, SST, HTR1A, PYY, GAST, HTR3A
39fluoxetine49 44 28 1110.9SLC6A4, TAC1, CYP3A4, CYP2D6, MAOA, OXT
40haloperidol44 28 2 49 1111.6CHGA, CYP2D6, CYP3A4, TAC1, PIK3C2A, HTR2A
415-hydroxytryptamine447.5SLC6A4, TAC1, MAOA, SST, CHGA, GAST
42propranolol44 28 49 11 2411.5HTR3A, SST, PYY, GHRH, CHGA, CYP2D6
43nicotine44 49 28 1110.5SLC6A4, OXT, TAC1, GAST, CHGA, MAOA
44nifedipine44 49 28 1110.5CYP2D6, OXT, CHGA, GHRH, GAST, SST
45acth447.4IFNA2, PYY, GAST, PIK3C2A, GHRH, CHGA
46gaba447.3CHGA, SLC6A4, TAC1, PYY, HTR3A, GAST
47norepinephrine44 11 249.1HTR3A, HTR1A, PYY, HTR2A, GAST, CHGA
48epinephrine44 11 248.5PIK3C2A, SLC6A4, TAC1, IFNA2, GAST, CHGA
49dopamine44 28 11 249.4HTR2A, GHRH, CHGA, SSTR1, OXT, MAOA
50testosterone44 59 11 249.2OXT, CHGA, GHRH, SST, CYP2D6, GAST

GO Terms for genes affiliated with Serotonin Syndrome

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Serotonin Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.8IFNA2, GHRH, SST, OXT, TAC1, PYY
2extracellular regionGO:0055766.0NOTCH1, PYY, IFNA2, GAST, CGB, GHRH

Biological processes related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.3HTR1A, HTR2A
2alkaloid catabolic processGO:00982210.2CYP2D6, CYP3A4
3serotonin receptor signaling pathwayGO:00721010.2HTR2A, HTR3A, HTR1A
4drug catabolic processGO:04273710.2CYP3A4, CYP2D6
5heterocycle metabolic processGO:04648310.2CYP2D6, CYP3A4
6monoterpenoid metabolic processGO:01609810.1CYP2D6, CYP3A4
7regulation of behaviorGO:05079510.1HTR2A, HTR1A
8negative regulation of organ growthGO:0466219.8SLC6A4, MEN1
9sperm ejaculationGO:0427139.7OXT, SLC6A4
10oxidative demethylationGO:0709899.7CYP3A4, CYP2D6
11sleepGO:0304319.6OXT, HTR2A
12memoryGO:0076139.6SLC6A4, OXT, HTR2A
13digestionGO:0075869.5PYY, HTR3A, SSTR1, SST
14response to nutrientGO:0075849.4SSTR1, SST, SLC6A4
15synaptic transmissionGO:0072688.9HTR3A, HTR2A, SST, MAOA, TAC1
16cell-cell signalingGO:0072678.0TAC1, PYY, IFNA2, CGB, GHRH, SSTR1

Molecular functions related to Serotonin Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.1HTR2A, HTR3A
2serotonin receptor activityGO:0049939.6HTR2A, HTR3A, HTR1A
3hormone activityGO:0051799.0SST, CGB, GAST, PYY

Products for genes affiliated with Serotonin Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Serotonin Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet