MCID: SRT004
MIFTS: 52

Serotonin Syndrome malady

Neuronal diseases, Rare diseases, Cancer diseases categories

Summaries for Serotonin Syndrome

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Wikipedia:63 Serotonin syndrome is a potential symptom of any number of life-threatening drug interactions which may... more...

MalaCards based summary: Serotonin Syndrome, also known as malignant carcinoid syndrome, is related to neuroleptic malignant syndrome and fibromyalgia. An important gene associated with Serotonin Syndrome is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Codeine and Morphine Pathway, Pharmacokinetics and Gefitinib Pathway, Pharmacokinetics. The drug interferon alfa-2b and the compounds mcpp and buspirone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and bone, and related mouse phenotypes are digestive/alimentary and renal/urinary system.

Aliases & Classifications for Serotonin Syndrome

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Sources:
47Orphanet, 60UMLS, 34MESH via Orphanet, 61UMLS via Orphanet
See all sources

Serotonin Syndrome, Aliases & Descriptions:

Name: Serotonin Syndrome 47
Malignant Carcinoid Syndrome 60
Serotonergic Syndrome 47
 
Serotonin Toxidrome 47
Serotonin Toxicity 47
Serotonin Storm 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
serotonergic syndrome:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet47 43116
MESH via Orphanet34 D020230
UMLS via Orphanet61 C0699828

Related Diseases for Serotonin Syndrome

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Diseases related to Serotonin Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1neuroleptic malignant syndrome31.0PIK3C2A, CYP2D6, HTR1A
2fibromyalgia30.3HTR2A, SLC6A4, TAC1, HTR3A
3acute myocardial infarction29.9PIK3C2A, HTR2A, HTR3A, SLC6A4
4myocardial infarction29.8PIK3C2A, HTR2A, HTR3A, SLC6A4
5migraine29.7CYP2D6, HTR2A, HTR3A, HTR1A, MAOA, TAC1
6obsessive-compulsive disorder29.7OXT, HTR2A, HTR3A, HTR1A, MAOA, SLC6A4
7melancholia10.5MAOA
8apudoma10.5SST
9gigantism10.5SST
10motion sickness10.5HTR3A, HTR1A
11duodenogastric reflux10.5GAST
12dysthymic disorder10.5HTR2A, MAOA
13pernicious anemia10.4GAST
14heart valve disease10.4HTR2A, HTR3A
15amnestic disorder10.4HTR3A, HTR1A
16alcoholic psychosis10.4SLC6A4
17cushing's syndrome10.4SST, GHRH
18peripheral vascular disease10.4TAC1
19agoraphobia10.4HTR1A, MAOA
20premature ejaculation10.4HTR1A, SLC6A4
21dumping syndrome10.4PYY, SST
22pituitary gland disease10.4SST, MEN1
23generalized anxiety disorder10.3HTR1A, SLC6A4
24bipolar disorder10.3HTR1A, SLC6A4
25acinar cell carcinoma10.3CHGA, GAST
26hyperprolactinemia10.3SST, GHRH, CGB
27major depressive disorder and accelerated response to antidepressant drug treatment10.3HTR1A, SLC6A4
28islet cell tumor10.3SST, GAST
29endogenous depression10.3MAOA, SLC6A4
30portal hypertension10.3SST, HTR2A, MAOA
31hyperthyroidism10.3CGB, GHRH, SST
32cocaine abuse10.3HTR3A, SLC6A4
33neuroendocrine tumor10.3CHGA, SST, GHRH
34bulimia nervosa10.3PYY, SLC6A4
35personality disorder10.3MAOA, SLC6A4
36anxiety disorder10.3HTR3A, MAOA, SLC6A4
37gastroparesis10.3HTR3A, GAST
38panic disorder10.3SLC6A4, HTR1A, HTR3A
39hyperinsulinemic hypoglycemia10.3SST, GAST
40drug dependence10.3MAOA, SLC6A4
41factor vii deficiency10.3IFNA2, SST, CHGA
42chronic fatigue syndrome10.3HTR1A, MAOA, SLC6A4
43primary hyperparathyroidism10.3CHGA, MEN1, GAST
44multiple endocrine neoplasia10.3CHGA, MEN1, GAST
45dyspepsia10.2HTR3A, GAST
46hyperparathyroidism10.2CHGA, MEN1, GAST
47antisocial personality disorder10.2HTR2A, MAOA, SLC6A4
48hypercalcemia10.2GAST, MEN1, CHGA
49diabetes insipidus10.2OXT, GHRH
50hyperinsulinemic hypoglycemia, familial, 210.2CHGA, SST, GAST

Graphical network of the top 20 diseases related to Serotonin Syndrome:



Diseases related to serotonin syndrome

Symptoms for Serotonin Syndrome

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Drugs & Therapeutics for Serotonin Syndrome

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Drug clinical trials:

Search ClinicalTrials for Serotonin Syndrome

Search NIH Clinical Center for Serotonin Syndrome

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Serotonin Syndrome

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Anatomical Context for Serotonin Syndrome

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MalaCards organs/tissues related to Serotonin Syndrome:

31
Brain, Bone marrow, Bone, Spinal cord, Heart, Hypothalamus

Animal Models for Serotonin Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Serotonin Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.9NOTCH1, GAST, HTR2A, MEN1, SST, OXT
2MP:00053677.6PIK3C2A, CHGA, OXT, HTR3A, TAC1, NOTCH1
3MP:00053857.4CHGA, OXT, MEN1, HTR1A, MAOA, TAC1
4MP:00053797.3CHGA, OXT, MEN1, HTR2A, HTR3A, GHRH
5MP:00036317.0PYY, OXT, SSTR1, SST, MEN1, HTR3A
6MP:00053786.9OXT, CHGA, PIK3C2A, PYY, SST, MEN1
7MP:00053866.9SST, SSTR1, OXT, PYY, HTR2A, HTR3A
8MP:00053765.6SLC6A4, PYY, PIK3C2A, CHGA, OXT, SSTR1

Publications for Serotonin Syndrome

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Articles related to Serotonin Syndrome:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Serotonin Syndrome and Opioids-What's the Deal? (25805026)
2015
2
A case of the serotonin syndrome secondary to phenelzine monotherapy at therapeutic dosing. (25861278)
2015
3
Incidence of serotonin syndrome in patients treated with fentanyl on serotonergic agents. (25675067)
2015
4
Serotonin syndrome: fentanyl and selective serotonin reuptake inhibitor interactions. (25842648)
2014
5
Editorial comment: serotonin syndrome after cardiopulmonary bypass: a case demonstrating the interaction between methylene blue and selective serotonin reuptake inhibitors and serotonin syndrome caused by administration of methylene blue to a patient receiving selective serotonin reuptake inhibitors. (25611877)
2014
6
Transient serotonin syndrome caused by concurrent use of tramadol and selective serotonin reuptake inhibitor. (25540831)
2014
7
Linezolid is associated with serotonin syndrome in a patient receiving amitriptyline, and fentanyl: a case report and review of the literature. (23533900)
2013
8
Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models. (22985508)
2012
9
Comment: Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. (22414792)
2012
10
Serotonin syndrome-muscle rigidity and confusion in the older adult. (22079646)
2012
11
Suspected serotonin syndrome in a patient being treated with methylene blue for ifosfamide encephalopathy. (22235061)
2012
12
A venlafaxine and mirtazapine-induced serotonin syndrome confirmed by de- and re-challenge. (22752315)
2012
13
Lethal serotonin syndrome after methylone and butylone ingestion. (22160789)
2012
14
Serotonin syndrome secondary to tramadol and citalopram. (21414947)
2011
15
Serotonin syndrome: an unusual cause of acute confusion and fever in the elderly. (22111101)
2011
16
The FDA alert on serotonin syndrome with use of triptans combined with selective serotonin reuptake inhibitors or selective serotonin-norepinephrine reuptake inhibitors: American Headache Society position paper. (20618823)
2010
17
Triptans, SSRIs/SNRIs and serotonin syndrome. (20618824)
2010
18
Venlafaxine-associated serotonin syndrome causing severe rhabdomyolysis and acute renal failure in a patient with idiopathic Parkinson disease. (20814334)
2010
19
Serotonin syndrome associated with linezolid use: a case report]. (20013432)
2009
20
Serotonin syndrome induced by duloxetine. (19452666)
2009
21
Serotonin syndrome associated with triptan monotherapy. (18480219)
2008
22
Serotonin syndrome in the oral and maxillofacial surgery office: a review of the literature and report of a case. (18718407)
2008
23
Deadly serotonin syndrome. (18783034)
2008
24
Treatment of acute mania with ambient air anionization: variants of climactic heat stress and serotonin syndrome. (17451018)
2007
25
Neuroleptic malignant syndrome and serotonin syndrome. (17645916)
2007
26
Serotonin syndrome. (17384366)
2007
27
Venlafaxine-associated serotonin syndrome and manic episode in a geriatric depressive patient. (16472373)
2006
28
Citalopram-induced serotonin syndrome: a case report. (16089311)
2005
29
Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. (14970364)
2004
30
Mirtazapine-induced serotonin syndrome. (12671522)
2003
31
Comment: combination risperidone and SSRI-induced serotonin syndrome. (14519058)
2003
32
Serotonin syndrome produced by a combination of venlafaxine and mirtazapine. (12478883)
2002
33
Serotonin syndrome - 'potential' role of the CYP2D6 genetic polymorphism in Asians. (12057035)
2002
34
Serotonin syndrome in HIV-infected individuals receiving antiretroviral therapy and fluoxetine. (11426073)
2001
35
Serotonin syndrome preceding pseudoseizures in an adolescent. (11739917)
2001
36
Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine. (11215836)
2001
37
Serotonin syndrome induced by fluvoxamine and mirtazapine. (11675850)
2001
38
Venlafaxine induced serotonin syndrome occurring after abstinence from phenelzine for more than two weeks. (9120894)
1997
39
The serotonin syndrome. (9255139)
1997
40
Selective serotonin reuptake inhibitor-induced serotonin syndrome: review. (9169967)
1997
41
The serotonin syndrome and psychosis-like side-effects of fluvoxamine clinical use--an estimation of incidence. (9088888)
1997
42
Serotonin syndrome due to an overdose of moclobemide and clomipramine. A potentially life-threatening association. (9037653)
1997
43
Serotonin syndrome after lithium add-on medication to paroxetine. (9211572)
1997
44
Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome. (8777769)
1996
45
Serotonin syndrome complicating migraine pharmacotherapy. (8869767)
1996
46
Serotonin syndrome in the elderly after antidepressive monotherapy. (8748434)
1995
47
Serotonin syndrome--a potentially fatal complication of antidepressant therapy. (7476638)
1995
48
Serotonin syndrome produced by a combination of fluoxetine and lithium. (8379573)
1993
49
Serotonin syndrome. (1636815)
1992
50
The serotonin syndrome. (2048681)
1991

Variations for Serotonin Syndrome

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Expression for genes affiliated with Serotonin Syndrome

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Search GEO for disease gene expression data for Serotonin Syndrome.

Pathways for genes affiliated with Serotonin Syndrome

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Pathways related to Serotonin Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Codeine and morphine metabolism36
9.8CYP3A4, CYP2D6
2
Show member pathways
9.8CYP3A4, CYP2D6
3
Show member pathways
9.5CYP2D6, CYP3A4, MAOA
4
Show member pathways
9.5CYP2D6, MAOA, CYP3A4
5
Show member pathways
9.3CYP3A4, SLC6A4, CYP2D6
69.2HTR3A, HTR2A, SLC6A4, MAOA, HTR1A
7
Show member pathways
8.9HTR3A, HTR1A, MAOA, SLC6A4, CYP2D6, HTR2A
8
Show member pathways
8.3OXT, HTR2A, GAST, TAC1
97.9HTR1A, SLC6A4, SST, HTR2A, HTR3A, SSTR1
10
Show member pathways
7.5HTR2A, TAC1, GHRH, HTR1A, SST, SSTR1
11
Show member pathways
6.3PYY, OXT, SSTR1, SST, MEN1, HTR2A

Compounds for genes affiliated with Serotonin Syndrome

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Compounds related to Serotonin Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 460)
idCompoundScoreTop Affiliating Genes
1mcpp439.5SLC6A4, HTR1A, CYP2D6, HTR2A, HTR3A
2buspirone43 28 1211.4HTR3A, CYP2D6, CYP3A4, HTR1A, HTR2A
3pindolol43 28 1211.4CYP2D6, HTR3A, SLC6A4, HTR1A, HTR2A
4fenfluramine43 28 1211.3SLC6A4, GHRH, HTR1A, HTR3A, HTR2A, CYP2D6
55-hydroxytryptophan439.3CHGA, HTR2A, HTR3A, HTR1A, SLC6A4, SST
6paroxetine43 49 28 1212.2SLC6A4, HTR1A, HTR3A, HTR2A, MAOA, CYP2D6
7trazodone43 28 1211.1HTR1A, CYP2D6, CYP3A4, SLC6A4, HTR2A
8granisetron49 43 1211.1TAC1, CYP2D6, CYP3A4, HTR2A, HTR3A
9nefazodone43 49 1211.1HTR2A, CYP2D6, CYP3A4, SLC6A4, HTR1A, HTR3A
10sertraline43 28 49 24 1213.1HTR3A, CYP2D6, CYP3A4, HTR1A, MAOA, SLC6A4
11venlafaxine43 49 24 1212.1CYP2D6, HTR1A, CYP3A4, HTR2A, HTR3A, SLC6A4
12trimipramine43 49 1211.0HTR2A, SLC6A4, HTR1A, CYP3A4, CYP2D6
13quetiapine43 49 28 24 1213.0CYP3A4, HTR1A, SLC6A4, HTR2A, CYP2D6, HTR3A
14fluvoxamine43 49 1211.0HTR2A, CYP2D6, CYP3A4, HTR3A, HTR1A, MAOA
15mianserin43 28 1210.9CYP3A4, HTR2A, HTR3A, HTR1A, MAOA, SLC6A4
16clomipramine43 49 1210.9MAOA, SLC6A4, HTR1A, CYP2D6, CYP3A4, HTR2A
17amitriptyline43 28 49 1211.9CYP3A4, HTR2A, HTR3A, CYP2D6, HTR1A, MAOA
18citalopram43 49 24 1211.9CYP3A4, HTR2A, HTR3A, MAOA, HTR1A, SLC6A4
19desipramine43 49 1210.9SLC6A4, HTR2A, HTR1A, MAOA, CYP3A4, CYP2D6
20risperidone43 49 28 59 24 1213.9HTR1A, SLC6A4, CYP2D6, CYP3A4, HTR3A, HTR2A
21imipramine43 28 49 24 1212.9SLC6A4, CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A
225-hydroxyindoleacetic acid43 249.8CHGA, SST, MAOA, GAST, SLC6A4, HTR3A
23escitalopram43 49 24 1211.8SLC6A4, HTR1A, HTR2A, CYP3A4, CYP2D6
24bromocriptine43 28 1210.8HTR1A, GHRH, HTR2A, SST, PIK3C2A, CYP3A4
25levodopa43 129.7TAC1, CHGA, HTR1A, MAOA, GHRH, SST
26yohimbine43 2 28 1211.7PYY, CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A
27mirtazapine43 49 1210.6HTR3A, HTR2A, SLC6A4, CYP2D6, CYP3A4
28omeprazole43 49 28 24 1212.6SST, CHGA, CYP3A4, CYP2D6, GAST, PYY
29amine438.5CYP2D6, SLC6A4, MAOA, PYY, CHGA, HTR3A
30amphetamine43 49 1210.5SST, TAC1, SLC6A4, CYP2D6, MAOA, PYY
31octreotide43 59 28 1211.4GAST, GHRH, IFNA2, SSTR1, SST, PYY
32clonidine43 49 28 1211.2SLC6A4, TAC1, GHRH, SST, CHGA, CYP3A4
33ondansetron49 43 24 1211.0CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A, SLC6A4
345-hydroxytryptamine437.7SLC6A4, TAC1, GAST, MAOA, HTR1A, HTR3A
35gnrh437.6SST, CHGA, OXT, PYY, GHRH, CGB
36propranolol43 28 49 24 1211.6CYP2D6, TAC1, CYP3A4, CHGA, SST, HTR3A
37fluoxetine43 49 28 1210.6SLC6A4, TAC1, CYP2D6, HTR3A, HTR2A, OXT
38haloperidol43 49 28 2 1211.6PYY, PIK3C2A, CYP2D6, CYP3A4, CHGA, HTR2A
39acetylcholine43 49 28 24 1211.6PYY, TAC1, GAST, HTR1A, HTR3A, SST
40thyroxine43 248.5PIK3C2A, OXT, IFNA2, SST, GHRH, GAST
41acth437.4HTR1A, GAST, GHRH, PYY, SST, CHGA
42nifedipine43 28 49 1210.4GAST, CYP2D6, CHGA, OXT, SST, GHRH
43gaba437.2SLC6A4, OXT, CHGA, PYY, HTR3A, MAOA
44nicotine43 28 49 1210.2CHGA, TAC1, GAST, SLC6A4, OXT, CYP2D6
45dexamethasone43 49 28 1210.1HTR3A, GHRH, MAOA, GAST, TAC1, SST
46epinephrine43 24 128.6SLC6A4, TAC1, GAST, IFNA2, SST, OXT
47estrogen436.5OXT, SLC6A4, NOTCH1, CHGA, TAC1, MEN1
48norepinephrine43 24 128.1SLC6A4, TAC1, GAST, MAOA, GHRH, HTR1A
49testosterone43 59 24 129.1OXT, CHGA, CYP3A4, CYP2D6, PIK3C2A, SST
50dopamine43 28 24 128.6HTR1A, HTR3A, HTR2A, SST, SSTR1, OXT

GO Terms for genes affiliated with Serotonin Syndrome

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Cellular components related to Serotonin Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430258.9SST, HTR2A, HTR3A, TAC1
2extracellular spaceGO:00056158.1TAC1, GHRH, IFNA2, SST, OXT, PYY
3extracellular regionGO:00055766.6CGB, PYY, CHGA, OXT, SST, IFNA2

Biological processes related to Serotonin Syndrome according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:004688310.4HTR1A, HTR2A
2serotonin receptor signaling pathwayGO:000721010.2HTR1A, HTR3A, HTR2A
3regulation of behaviorGO:005079510.2HTR2A, HTR1A
4alkaloid catabolic processGO:000982210.1CYP3A4, CYP2D6
5drug catabolic processGO:004273710.1CYP3A4, CYP2D6
6heterocycle metabolic processGO:004648310.0CYP2D6, CYP3A4
7negative regulation of organ growthGO:004662110.0MEN1, SLC6A4
8monoterpenoid metabolic processGO:001609810.0CYP2D6, CYP3A4
9oxidative demethylationGO:007098910.0CYP2D6, CYP3A4
10sleepGO:00304319.6HTR2A, OXT
11digestionGO:00075869.6PYY, SSTR1, SST, HTR3A
12vasoconstrictionGO:00423109.6SLC6A4, HTR1A
13response to nutrientGO:00075849.5SLC6A4, SST, SSTR1
14positive regulation of cell proliferationGO:00082849.5NOTCH1, GHRH, HTR1A, HTR2A
15sperm ejaculationGO:00427139.5OXT, SLC6A4
16response to foodGO:00320949.5GHRH, OXT
17synaptic transmissionGO:00072689.3SST, HTR2A, HTR3A, MAOA, TAC1
18memoryGO:00076139.3OXT, HTR2A, SLC6A4
19G-protein coupled receptor signaling pathwayGO:00071869.3GAST, HTR1A, SST, PYY
20positive regulation of ossificationGO:00457789.2TAC1, OXT
21positive regulation of renal sodium excretionGO:00358159.1TAC1, OXT
22negative regulation of cell proliferationGO:00082859.1SSTR1, SST, MEN1, NOTCH1
23cell-cell signalingGO:00072678.6CGB, TAC1, GHRH, IFNA2, SST, SSTR1

Molecular functions related to Serotonin Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:005137810.1HTR3A, HTR2A
2serotonin receptor activityGO:00049939.8HTR1A, HTR3A, HTR2A
3hormone activityGO:00051798.8CGB, GAST, SST, PYY

Products for genes affiliated with Serotonin Syndrome

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Sources for Serotonin Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet