MCID: SRT004
MIFTS: 59

Serotonin Syndrome malady

Neuronal diseases, Rare diseases, Cancer diseases categories
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Summaries for Serotonin Syndrome

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65Wikipedia, 33MalaCards
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Wikipedia:65 Serotonin syndrome is a potentially life-threatening drug reaction that may occur following therapeutic... more...

MalaCards: Serotonin Syndrome, also known as malignant carcinoid syndrome, is related to neuroleptic malignant syndrome and parkinson's disease. An important gene associated with Serotonin Syndrome is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Codeine and Morphine Pathway, Pharmacokinetics and Gefitinib Pathway, Pharmacokinetics. The drug interferon alfa-2b and the compounds mcpp and buspirone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and brain, and related mouse phenotypes are digestive/alimentary and renal/urinary system.

Aliases & Classifications for Serotonin Syndrome

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49Orphanet, 62UMLS, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
serotonergic syndrome:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

serotonin syndrome 49
malignant carcinoid syndrome 62
serotonergic syndrome 49
serotonin toxidrome 49
serotonin toxicity 49
serotonin storm 49


External Ids:

MESH via Orphanet36 D020230
SNOMED-CT via Orphanet59 371089000
UMLS via Orphanet63 C0699828

Related Diseases for Serotonin Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Serotonin Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1neuroleptic malignant syndrome30.8PIK3C2A, CYP2D6, HTR1A
2parkinson's disease30.1CYP2D6, HTR1A, MAOA, TAC1
3fibromyalgia30.1HTR2A, SLC6A4, TAC1, HTR3A
4migraine30.0CYP2D6, HTR2A, HTR3A, HTR1A, MAOA, TAC1
5acute myocardial infarction29.9PIK3C2A, HTR2A, HTR3A, SLC6A4
6myocardial infarction29.9PIK3C2A, HTR2A, HTR3A, SLC6A4
7obsessive-compulsive disorder29.8OXT, HTR2A, HTR3A, HTR1A, MAOA, SLC6A4
8cerebritis10.2
9melancholia10.1MAOA
10apudoma10.1SST
11gigantism10.1SST
12motion sickness10.1HTR3A, HTR1A
13duodenogastric reflux10.1GAST
14dysthymic disorder10.1HTR2A, MAOA
15pernicious anemia10.1GAST
16heart valve disease10.1HTR2A, HTR3A
17alcoholic psychosis10.1SLC6A4
18amnestic disorder10.1HTR3A, HTR1A
19cushing's syndrome10.1SST, GHRH
20agoraphobia10.1HTR1A, MAOA
21peripheral vascular disease10.1TAC1
22premature ejaculation10.1HTR1A, SLC6A4
23dumping syndrome10.1PYY, SST
24pituitary gland disease10.1SST, MEN1
25generalized anxiety disorder10.1HTR1A, SLC6A4
26bipolar disorder10.1HTR1A, SLC6A4
27acinar cell carcinoma10.1CHGA, GAST
28hyperprolactinemia10.1SST, GHRH, CGB
29endogenous depression10.1HTR1A, SLC6A4
30islet cell tumor10.1SST, GAST
31portal hypertension10.1SST, HTR2A, MAOA
32hyperthyroidism10.1CGB, GHRH, SST
33vascular disease10.1
34chronic pain10.1
35headache10.1
36cocaine abuse10.1HTR3A, SLC6A4
37neuroendocrine tumor10.1CHGA, SST, GHRH
38bulimia nervosa10.1PYY, SLC6A4
39anxiety disorder10.1HTR3A, MAOA, SLC6A4
40personality disorder10.1MAOA, SLC6A4
41panic disorder10.1SLC6A4, HTR1A, HTR3A
42gastroparesis10.1HTR3A, GAST
43hyperinsulinemic hypoglycemia10.1SST, GAST
44factor vii deficiency10.1IFNA2, SST, CHGA
45chronic fatigue syndrome10.1HTR1A, MAOA, SLC6A4
46drug dependence10.1MAOA, SLC6A4
47primary hyperparathyroidism10.1CHGA, MEN1, GAST
48seasonal affective disorder10.1HTR2A, HTR1A, SLC6A4
49multiple endocrine neoplasia10.1CHGA, MEN1, GAST
50hyperparathyroidism10.1CHGA, MEN1, GAST

Graphical network of the top 20 diseases related to Serotonin Syndrome:



Diseases related to serotonin syndrome

Symptoms for Serotonin Syndrome

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Drugs & Therapeutics for Serotonin Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Serotonin Syndrome

Search NIH Clinical Center for Serotonin Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Serotonin Syndrome

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Anatomical Context for Serotonin Syndrome

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33MalaCards
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MalaCards organs/tissues related to Serotonin Syndrome:

33
Bone marrow, Bone, Brain, Spinal cord, Heart, Hypothalamus

Animal Models for Serotonin Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Serotonin Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053817.9SST, OXT, HTR2A, GAST, NOTCH1, MEN1
2MP:00053677.6PIK3C2A, CHGA, OXT, HTR3A, TAC1, NOTCH1
3MP:00053857.4NOTCH1, TAC1, CHGA, OXT, MAOA, HTR1A
4MP:00053797.3SLC6A4, NOTCH1, GAST, GHRH, HTR3A, HTR2A
5MP:00036317.0HTR1A, OXT, NOTCH1, SSTR1, SST, MEN1
6MP:00053786.9PYY, NOTCH1, SLC6A4, PIK3C2A, GHRH, CHGA
7MP:00053866.9OXT, TAC1, MAOA, HTR1A, HTR3A, HTR2A
8MP:00053765.6HTR3A, PYY, PIK3C2A, CHGA, SSTR1, OXT

Publications for Serotonin Syndrome

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Sources:
52PubMed
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Articles related to Serotonin Syndrome:

(show top 50)    (show all 474)
idTitleAuthorsYear
1
Linezolid is associated with serotonin syndrome in a patient receiving amitriptyline, and fentanyl: a case report and review of the literature. (23533900)
2013
2
Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models. (22985508)
2012
3
Comment: Neuroleptic malignant syndrome versus serotonin syndrome: the search for a diagnostic tool. (22414792)
2012
4
Serotonin syndrome-muscle rigidity and confusion in the older adult. (22079646)
2012
5
Suspected serotonin syndrome in a patient being treated with methylene blue for ifosfamide encephalopathy. (22235061)
2012
6
A venlafaxine and mirtazapine-induced serotonin syndrome confirmed by de- and re-challenge. (22752315)
2012
7
Lethal serotonin syndrome after methylone and butylone ingestion. (22160789)
2012
8
Serotonin syndrome secondary to tramadol and citalopram. (21414947)
2011
9
Serotonin syndrome: an unusual cause of acute confusion and fever in the elderly. (22111101)
2011
10
Rasagiline-induced serotonin syndrome. (21370275)
2011
11
The FDA alert on serotonin syndrome with use of triptans combined with selective serotonin reuptake inhibitors or selective serotonin-norepinephrine reuptake inhibitors: American Headache Society position paper. (20618823)
2010
12
Triptans, SSRIs/SNRIs and serotonin syndrome. (20618824)
2010
13
Venlafaxine-associated serotonin syndrome causing severe rhabdomyolysis and acute renal failure in a patient with idiopathic Parkinson disease. (20814334)
2010
14
Serotonin syndrome associated with linezolid use: a case report]. (20013432)
2009
15
Serotonin syndrome induced by duloxetine. (19452666)
2009
16
Serotonin syndrome associated with triptan monotherapy. (18480219)
2008
17
Serotonin syndrome in the oral and maxillofacial surgery office: a review of the literature and report of a case. (18718407)
2008
18
Deadly serotonin syndrome. (18783034)
2008
19
Drug-induced serotonin syndrome: a review. (18759711)
2008
20
Treatment of acute mania with ambient air anionization: variants of climactic heat stress and serotonin syndrome. (17451018)
2007
21
Neuroleptic malignant syndrome and serotonin syndrome. (17645916)
2007
22
Serotonin syndrome. (17384366)
2007
23
Venlafaxine-associated serotonin syndrome and manic episode in a geriatric depressive patient. (16472373)
2006
24
Citalopram-induced serotonin syndrome: a case report. (16089311)
2005
25
Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. (14970364)
2004
26
Mirtazapine-induced serotonin syndrome. (12671522)
2003
27
Comment: combination risperidone and SSRI-induced serotonin syndrome. (14519058)
2003
28
Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. (12830431)
2003
29
Serotonin syndrome produced by a combination of venlafaxine and mirtazapine. (12478883)
2002
30
Serotonin syndrome - 'potential' role of the CYP2D6 genetic polymorphism in Asians. (12057035)
2002
31
Serotonin syndrome in HIV-infected individuals receiving antiretroviral therapy and fluoxetine. (11426073)
2001
32
Serotonin syndrome preceding pseudoseizures in an adolescent. (11739917)
2001
33
Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine. (11215836)
2001
34
Serotonin syndrome induced by fluvoxamine and mirtazapine. (11675850)
2001
35
Serotonin syndrome in a teenager following overdose of dothiepine hydrochloride. (10214923)
1998
36
Serotonin syndrome: history and risk. (9794145)
1998
37
Venlafaxine induced serotonin syndrome occurring after abstinence from phenelzine for more than two weeks. (9120894)
1997
38
The serotonin syndrome. (9255139)
1997
39
Selective serotonin reuptake inhibitor-induced serotonin syndrome: review. (9169967)
1997
40
The serotonin syndrome and psychosis-like side-effects of fluvoxamine clinical use--an estimation of incidence. (9088888)
1997
41
Serotonin syndrome due to an overdose of moclobemide and clomipramine. A potentially life-threatening association. (9037653)
1997
42
Serotonin syndrome after lithium add-on medication to paroxetine. (9211572)
1997
43
Ssri-related toxic serotonin syndrome: improvement by discontinuation of treatment and propranolol. (19698545)
1997
44
Ecstasy intoxication: an overlap between serotonin syndrome and neuroleptic malignant syndrome. (8777769)
1996
45
Serotonin syndrome complicating migraine pharmacotherapy. (8869767)
1996
46
Serotonin syndrome in the elderly after antidepressive monotherapy. (8748434)
1995
47
Serotonin syndrome--a potentially fatal complication of antidepressant therapy. (7476638)
1995
48
Serotonin syndrome produced by a combination of fluoxetine and lithium. (8379573)
1993
49
Serotonin syndrome. (1636815)
1992
50
The serotonin syndrome. (2048681)
1991

Variations for Serotonin Syndrome

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Expression for genes affiliated with Serotonin Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Serotonin Syndrome

Search GEO for disease gene expression data for Serotonin Syndrome.

Pathways for genes affiliated with Serotonin Syndrome

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Sources:
50PathCards, 51PharmGKB, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 30KEGG
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Pathways related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Codeine and morphine metabolism38
9.8CYP3A4, CYP2D6
2
Show member pathways
9.8CYP3A4, CYP2D6
3
Show member pathways
9.5CYP2D6, CYP3A4, MAOA
4
Show member pathways
9.5CYP2D6, MAOA, CYP3A4
5
Show member pathways
9.3CYP3A4, SLC6A4, CYP2D6
69.2HTR3A, HTR2A, SLC6A4, MAOA, HTR1A
7
Show member pathways
8.9HTR3A, HTR1A, MAOA, SLC6A4, CYP2D6, HTR2A
8
Show member pathways
8.3OXT, HTR2A, GAST, TAC1
97.9HTR1A, SLC6A4, SST, HTR2A, HTR3A, SSTR1
10
Show member pathways
7.5HTR2A, TAC1, GHRH, HTR1A, SST, SSTR1
11
Show member pathways
6.3PYY, OXT, SSTR1, SST, MEN1, HTR2A

Compounds for genes affiliated with Serotonin Syndrome

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 460)
idCompoundScoreTop Affiliating Genes
1mcpp459.5SLC6A4, HTR1A, CYP2D6, HTR2A, HTR3A
2buspirone45 29 1111.4HTR3A, CYP2D6, CYP3A4, HTR1A, HTR2A
3pindolol45 29 1111.4CYP2D6, HTR3A, SLC6A4, HTR1A, HTR2A
4fenfluramine45 29 1111.3SLC6A4, GHRH, HTR1A, HTR3A, HTR2A, CYP2D6
55-hydroxytryptophan459.3CHGA, HTR2A, HTR3A, HTR1A, SLC6A4, SST
6paroxetine45 51 29 1112.2SLC6A4, HTR1A, HTR3A, HTR2A, MAOA, CYP2D6
7trazodone45 29 1111.1HTR1A, CYP2D6, CYP3A4, SLC6A4, HTR2A
8granisetron51 45 1111.1TAC1, CYP2D6, CYP3A4, HTR2A, HTR3A
9nefazodone45 51 1111.1HTR2A, CYP2D6, CYP3A4, SLC6A4, HTR1A, HTR3A
10sertraline45 29 51 24 1113.1HTR3A, CYP2D6, CYP3A4, HTR1A, MAOA, SLC6A4
11venlafaxine45 51 24 1112.1CYP2D6, HTR1A, CYP3A4, HTR2A, HTR3A, SLC6A4
12trimipramine45 51 1111.0HTR2A, SLC6A4, HTR1A, CYP3A4, CYP2D6
13quetiapine45 51 29 24 1113.0CYP3A4, HTR1A, SLC6A4, HTR2A, CYP2D6, HTR3A
14fluvoxamine45 51 1111.0HTR2A, CYP2D6, CYP3A4, HTR3A, HTR1A, MAOA
15mianserin45 29 1110.9CYP3A4, HTR2A, HTR3A, HTR1A, MAOA, SLC6A4
16clomipramine45 51 1110.9MAOA, SLC6A4, HTR1A, CYP2D6, CYP3A4, HTR2A
17amitriptyline45 29 51 1111.9CYP3A4, HTR2A, HTR3A, CYP2D6, HTR1A, MAOA
18citalopram45 51 24 1111.9CYP3A4, HTR2A, HTR3A, MAOA, HTR1A, SLC6A4
19desipramine45 51 1110.9SLC6A4, HTR2A, HTR1A, MAOA, CYP3A4, CYP2D6
20risperidone45 51 29 61 24 1113.9HTR1A, SLC6A4, CYP2D6, CYP3A4, HTR3A, HTR2A
21imipramine45 29 51 24 1112.9SLC6A4, CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A
225-hydroxyindoleacetic acid45 249.8CHGA, SST, MAOA, GAST, SLC6A4, HTR3A
23escitalopram45 51 24 1111.8SLC6A4, HTR1A, HTR2A, CYP3A4, CYP2D6
24bromocriptine45 29 1110.8HTR1A, GHRH, HTR2A, SST, PIK3C2A, CYP3A4
25levodopa45 119.7TAC1, CHGA, HTR1A, MAOA, GHRH, SST
26yohimbine45 3 29 1111.7PYY, CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A
27mirtazapine45 51 1110.6HTR3A, HTR2A, SLC6A4, CYP2D6, CYP3A4
28omeprazole45 51 29 24 1112.6SST, CHGA, CYP3A4, CYP2D6, GAST, PYY
29amine458.5CYP2D6, SLC6A4, MAOA, PYY, CHGA, HTR3A
30amphetamine45 51 1110.5SST, TAC1, SLC6A4, CYP2D6, MAOA, PYY
31octreotide45 61 29 1111.4GAST, GHRH, IFNA2, SSTR1, SST, PYY
32clonidine45 51 29 1111.2SLC6A4, TAC1, GHRH, SST, CHGA, CYP3A4
33ondansetron51 45 24 1111.0CYP2D6, CYP3A4, HTR2A, HTR3A, HTR1A, SLC6A4
345-hydroxytryptamine457.7SLC6A4, TAC1, GAST, MAOA, HTR1A, HTR3A
35gnrh457.6SST, CHGA, OXT, PYY, GHRH, CGB
36propranolol45 29 51 24 1111.6CYP2D6, TAC1, CYP3A4, CHGA, SST, HTR3A
37fluoxetine45 51 29 1110.6SLC6A4, TAC1, CYP2D6, HTR3A, HTR2A, OXT
38haloperidol45 51 29 3 1111.6PYY, PIK3C2A, CYP2D6, CYP3A4, CHGA, HTR2A
39acetylcholine45 51 29 24 1111.6PYY, TAC1, GAST, HTR1A, HTR3A, SST
40thyroxine45 248.5PIK3C2A, OXT, IFNA2, SST, GHRH, GAST
41acth457.4HTR1A, GAST, GHRH, PYY, SST, CHGA
42nifedipine45 29 51 1110.4GAST, CYP2D6, CHGA, OXT, SST, GHRH
43gaba457.2SLC6A4, OXT, CHGA, PYY, HTR3A, MAOA
44nicotine45 29 51 1110.2CHGA, TAC1, GAST, SLC6A4, OXT, CYP2D6
45dexamethasone45 51 29 1110.1HTR3A, GHRH, MAOA, GAST, TAC1, SST
46epinephrine45 24 118.6SLC6A4, TAC1, GAST, IFNA2, SST, OXT
47estrogen456.5OXT, SLC6A4, NOTCH1, CHGA, TAC1, MEN1
48norepinephrine45 24 118.1SLC6A4, TAC1, GAST, MAOA, GHRH, HTR1A
49testosterone45 61 24 119.1OXT, CHGA, CYP3A4, CYP2D6, PIK3C2A, SST
50dopamine45 29 24 118.6HTR1A, HTR3A, HTR2A, SST, SSTR1, OXT

GO Terms for genes affiliated with Serotonin Syndrome

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16Gene Ontology
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Cellular components related to Serotonin Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.9HTR2A, HTR3A, TAC1, SST
2extracellular spaceGO:0056158.1SST, OXT, PYY, IFNA2, GHRH, TAC1
3extracellular regionGO:0055766.6CGB, PYY, CHGA, OXT, SST, IFNA2

Biological processes related to Serotonin Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.4HTR1A, HTR2A
2serotonin receptor signaling pathwayGO:00721010.2HTR1A, HTR3A, HTR2A
3regulation of behaviorGO:05079510.2HTR2A, HTR1A
4alkaloid catabolic processGO:00982210.1CYP3A4, CYP2D6
5drug catabolic processGO:04273710.1CYP3A4, CYP2D6
6heterocycle metabolic processGO:04648310.0CYP2D6, CYP3A4
7negative regulation of organ growthGO:04662110.0MEN1, SLC6A4
8monoterpenoid metabolic processGO:01609810.0CYP2D6, CYP3A4
9oxidative demethylationGO:07098910.0CYP2D6, CYP3A4
10sleepGO:0304319.6HTR2A, OXT
11digestionGO:0075869.6PYY, SSTR1, SST, HTR3A
12vasoconstrictionGO:0423109.6SLC6A4, HTR1A
13response to nutrientGO:0075849.5SLC6A4, SST, SSTR1
14positive regulation of cell proliferationGO:0082849.5NOTCH1, GHRH, HTR1A, HTR2A
15sperm ejaculationGO:0427139.5OXT, SLC6A4
16response to foodGO:0320949.5GHRH, OXT
17synaptic transmissionGO:0072689.3SST, HTR2A, HTR3A, MAOA, TAC1
18memoryGO:0076139.3OXT, HTR2A, SLC6A4
19G-protein coupled receptor signaling pathwayGO:0071869.3GAST, HTR1A, SST, PYY
20positive regulation of ossificationGO:0457789.2TAC1, OXT
21positive regulation of renal sodium excretionGO:0358159.1TAC1, OXT
22negative regulation of cell proliferationGO:0082859.1SSTR1, SST, MEN1, NOTCH1
23cell-cell signalingGO:0072678.6CGB, TAC1, GHRH, IFNA2, SST, SSTR1

Molecular functions related to Serotonin Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.1HTR3A, HTR2A
2serotonin receptor activityGO:0049939.8HTR1A, HTR3A, HTR2A
3hormone activityGO:0051798.8CGB, GAST, SST, PYY

Products for genes affiliated with Serotonin Syndrome

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Serotonin Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet