MCID: SRS001
MIFTS: 57

Serous Cystadenocarcinoma malady

Cancer diseases category

Summaries for Serous Cystadenocarcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cystadenocarcinoma that derives from epithelial cells originating in glandular tissue forming serous lesions.

MalaCards: Serous Cystadenocarcinoma, also known as serous cystadenocarcinoma, nos, is related to cystadenocarcinoma and adenocarcinoma. An important gene associated with Serous Cystadenocarcinoma is ESR2 (estrogen receptor 2 (ER beta)), and among its related pathways are IL-3 Signaling Pathway and TNF Signaling. The compounds resveratrol and idoxifene have been mentioned in the context of this disorder. Affiliated tissues include ovary, pancreas and testis, and related mouse phenotypes are hearing/vestibular/ear and integument.

Wikipedia:63 Serous cystadenocarcinoma is a type of tumor in the cystadenocarcinoma grouping. more...

Aliases & Classifications for Serous Cystadenocarcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

serous cystadenocarcinoma 8 10
serous cystadenocarcinoma, nos 8
cystadenocarcinoma, serous 60
cystadenocarcinoma serous 44
serous adenocarcinoma 8
serous carcinoma 8


External Ids:

Disease Ontology8 DOID:3114
MeSH34 D018284
SNOMED-CT56 189685001, 90725004

Related Diseases for Serous Cystadenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Serous Cystadenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1cystadenocarcinoma31.6MUC16
2adenocarcinoma31.3BAX, VEGFA, AKT1, FAS, MUC16, PGR
3ovarian serous cystadenocarcinoma31.2ZNF217, MUC16, USP2, USP14, UBE4A
4papillary carcinoma31.2ESR1, PGR, MUC16
5endometrial carcinoma30.8BCL2, ESR2, ESR1, PGR, MUC16
6peritonitis30.5MUC16
7ovarian cancer30.3FAS, AKT1, VEGFA, BAX, MUC16, CYP19A1
8breast cancer30.2FAS, AKT1, VEGFA, BAX, MUC16, CYP19A1
9adenofibroma30.1MUC16
10leiomyosarcoma30.1PGR, MUC16
11endometriosis30.1VEGFA, MUC16, CYP19A1, PGR, ESR1, ESR2
12leukemia30.1FAS, AKT1, BAX, BIRC5, ESR2, BCL2
13malignant mesothelioma30.0MUC16
14astrocytoma30.0VEGFA, AKT1
15gastric adenocarcinoma30.0FAS, BAX, MUC16, BIRC5, BCL2
16lung adenocarcinoma30.0FAS, VEGFA, BAX, MUC16, BIRC5, ESR2
17rhabdomyosarcoma29.9AKT1
18tuberous sclerosis29.9AKT1
19ovarian disease29.9MUC16, CYP19A1
20lymphangioleiomyomatosis29.9ESR1, PGR
21leiomyoma29.9CYP19A1, PGR, ESR1, ESR2
22melanoma29.9FAS, AKT1, VEGFA, BAX, BIRC5, BCL2
23papillary cystadenocarcinoma10.8
24ovarian cystadenocarcinoma10.8
25papillary adenocarcinoma10.7
26ovary serous adenocarcinoma10.5
27pancreatic serous cystadenocarcinoma10.5
28ovary adenocarcinoma10.5
29peritoneal serous adenocarcinoma10.5
30fallopian tube serous adenocarcinoma10.4
31pancreatic cystadenocarcinoma10.4
32pancreatitis10.4
33ovarian malignant mesothelioma10.3
34ovary papillary carcinoma10.3
35cervical serous adenocarcinoma10.2
36uterine ligament serous adenocarcinoma10.2
37peritoneal serous papillary adenocarcinoma10.2
38fallopian tube adenocarcinoma10.2
39hepatitis10.2
40malignant peritoneal mesothelioma10.2
41in situ carcinoma10.2
42uterine corpus serous adenocarcinoma10.2
43breast adenocarcinoma10.2
44endometrial adenocarcinoma10.2
45endocervical carcinoma10.1
46neuroendocrine carcinoma10.1
47endocervicitis10.1
48large cell carcinoma10.1
49transitional cell carcinoma10.1
50uterine disease10.1

Graphical network of the top 20 diseases related to Serous Cystadenocarcinoma:



Diseases related to serous cystadenocarcinoma

Clinical Features for Serous Cystadenocarcinoma

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Drugs & Therapeutics for Serous Cystadenocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Serous Cystadenocarcinoma

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Genetic Tests for Serous Cystadenocarcinoma

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Anatomical Context for Serous Cystadenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Serous Cystadenocarcinoma:

32
Ovary, Pancreas, Testis, Colon, Breast, Bone, Liver, Spleen, Lymph node, Testes

Animal Models for Serous Cystadenocarcinoma or affiliated genes

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36MGI
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Publications for Serous Cystadenocarcinoma

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50PubMed
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Articles related to Serous Cystadenocarcinoma:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Serous papillary cystadenocarcinoma in supernumerary ovary. (23550880)
2013
2
Histological percutaneous diagnosis of stage IV microcystic serous cystadenocarcinoma of the pancreas. (23370947)
2013
3
Serous cystadenocarcinoma of pancreas. (23763806)
2013
4
Ovarian serous cystadenocarcinoma metastasising to the breast. (23445161)
2013
5
Serous cystadenocarcinoma of the pancreas: report of a case and management reflections. (22400805)
2012
6
Imaging of pancreatic serous cystadenocarcinoma. (22009426)
2011
7
A rare case of serous papillary cystadenocarcinoma of the testis. (20133965)
2010
8
Nanog is highly expressed in ovarian serous cystadenocarcinoma and correlated with clinical stage and pathological grade. (21266826)
2010
9
Serous ovarian cystadenocarcinoma incidentally discovered in a 29-year-old patient: case report. (21077487)
2010
10
Collision tumor: serous cystadenocarcinoma and dermoid cyst in the same ovary. (18818939)
2009
11
Serous cystadenocarcinoma of the pancreas with metachronous hepatic metastasis. (19060596)
2008
12
Macrocystic serous cystadenocarcinoma of the pancreas: the first report of a new pattern of pancreatic carcinoma. (18305183)
2008
13
Immunohistochemical identification of primary peritoneal serous cystadenocarcinoma mimicking advanced colorectal carcinoma: a case report. (18036260)
2007
14
Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues]. (17553343)
2007
15
ZNF217 gene was detected in ovarian serous cystadenocarcinoma by fluorescence in situ hybridization]. (17160949)
2006
16
Serous cystadenocarcinoma of the pancreas: management of a rare entity. (16025006)
2005
17
Primary papillary serous cystadenocarcinoma of broad ligament. (15845057)
2005
18
Hepatic resection of metastatic tumor from serous cystadenocarcinoma of the ovary. (12068151)
2002
19
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis. (11516810)
2001
20
Serous papillary cystadenocarcinoma of the ovary diagnosed with the ThinPrep Pap Test. (11127748)
2000
21
Estrogen receptor alpha (ER-alpha) and beta (ER-beta) mRNAs in normal ovary, ovarian serous cystadenocarcinoma and ovarian cancer cell lines: down-regulation of ER-beta in neoplastic tissues. (9506768)
1998
22
Prognostic significance of DNA ploidy and S-phase fraction in malignant serous cystadenocarcinoma of the ovary. (9642449)
1998
23
Case report: Serous cystadenocarcinoma of the retroperitoneum: CT and sonographic appearance. (9867279)
1998
24
Serous cystadenocarcinoma of the pancreas with liver metastases. (9931400)
1998
25
Serous cystadenocarcinoma and ovarian teratoma during pregnancy. (8737305)
1996
26
Estrogen and progesterone receptor status as prognostic indicators in patients with optimally cytoreduced stage IIIc serous cystadenocarcinoma of the ovary. (8774651)
1996
27
Serous cystadenocarcinoma of the pancreas. (8968870)
1996
28
Ovarian-type papillary serous cystadenocarcinoma of the testis. (8653294)
1996
29
Morphologic criteria for the prognosis of serous cystadenocarcinoma of the ovary. (7737584)
1995
30
Papillary serous cystadenocarcinoma arising in benign glandular inclusion cysts in pelvic and inguinal lymph nodes. (9205465)
1994
31
Primary retroperitoneal serous cystadenocarcinoma of 'ovarian-type': US and CT findings. (8223678)
1993
32
Tumor DNA ploidy and prognosis of patients with serous cystadenocarcinoma of the ovary. (8334634)
1993
33
Heterophile antigens in serous cystadenocarcinoma of the human ovary. (1283511)
1992
34
A rare case of serous cystadenocarcinoma of the pancreas. (1568167)
1992
35
Transition from benign to malignant epithelium in mucinous and serous ovarian cystadenocarcinoma. (1427402)
1992
36
Osseous metaplasia in ovarian papillary serous cystadenocarcinoma. (2121630)
1990
37
Experiments with tissue cultures from a human ovarian serous cystadenocarcinoma producing cancer antigen 125 (CA125), tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA). (3165255)
1988
38
Simultaneous occurrence of a granulosa cell tumour and a serous papillary cystadenocarcinoma in the same ovary. A case report. (4036607)
1985
39
Cytogenetics of a cell line derived from an ovarian papillary serous cystadenocarcinoma. (6744227)
1984
40
Serous papillary cystadenocarcinoma associated with alpha-fetoprotein production. (6205636)
1984
41
Occurrence of bone in serous cystadenocarcinoma of the ovary. (6816209)
1982
42
Nature of carcinoembryonic antigen purified from malignant ascitic fluid of serous cystadenocarcinoma of the ovary. (7300840)
1981
43
Ultrasonic diagnosis of serous cystadenocarcinoma of the ovary. (874359)
1977
44
Primary leiomyosarcoma associated with serous cystadenocarcinoma of the ovary. (858555)
1977
45
Immunologic studies of human serous cystadenocarcinoma of ovary. Demonstration of tumor-associated antigens. (4632680)
1973
46
Hypoglycemia associated with serous cystadenocarcinoma of the ovary. (4189963)
1970
47
Antigenicity of papillary serous cystadenocarcinoma tissue culture cells. (4970936)
1968
48
Serous cystadenocarcinoma of ovary, bilateral, stage II, six-year survival. A case report. (13981334)
1963
49
Disseminated endosalpingiosis associated with bilateral papillary serous cystadenocarcinoma of the ovaries. A case report. (13909448)
1962
50
Serous cystadenocarcinoma of the ovary; a review of 127 cases. (13056935)
1953

Genetic Variations for Serous Cystadenocarcinoma

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Expression for genes affiliated with Serous Cystadenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Serous Cystadenocarcinoma

Search GEO for disease gene expression data for Serous Cystadenocarcinoma.

Pathways for genes affiliated with Serous Cystadenocarcinoma

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Sources:
37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 53Reactome, 51QIAGEN, 49PharmGKB, 12EMD Millipore, 29KEGG, 4Cell Signaling Technology
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Pathways related to Serous Cystadenocarcinoma according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3BIRC5
2
Hide members
10.3AKT1
310.0ESR2, PGR, CYP19A1
49.9BCL2, BIRC5, AKT1
59.9ESR2, ESR1, AKT1
69.9ESR2, ESR1, AKT1
7
Hide members
9.9ESR2, ESR1, PGR
89.9BCL2, BAX, AKT1
9
Hide members
9.9AKT1, BAX, BCL2
10
Hide members
9.9AKT1, BAX, BCL2
119.9AKT1, BAX, BCL2
12
Hide members
9.9ESR2, ESR1, CYP19A1
139.9BCL2, BAX, FAS
149.9BCL2, ESR1, AKT1
15
Hide members
9.8BCL2, BIRC5, BAX, AKT1
169.7FAS, BAX, BIRC5, BCL2
17
Apoptosis and survival Apoptotic TNF-family pathways
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9.7BCL2, BIRC5, BAX, FAS
18
Apoptosis and survival Caspase cascade
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9.7FAS, AKT1, BAX, BCL2
19
Hide members
9.7FAS, AKT1, BAX, BCL2
20
Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
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9.7BAX, ESR1, ESR2, BCL2
21
Development Endothelin-1/EDNRA signaling
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9.7AKT1, VEGFA, ESR1, ESR2
229.7ESR1, VEGFA, AKT1, FAS
23
Hide members
9.6FAS, AKT1, BAX, BIRC5, BCL2
24
Hide members
9.6FAS, AKT1, BAX, BIRC5, BCL2
25
Development Prolactin receptor signaling
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9.6AKT1, BAX, ESR1, ESR2, BCL2
269.4AKT1, AMY1A, AMY1B, AMY1C
27
Hide members
9.4AMY1C, AMY1B, AMY1A, CYP19A1
289.4FAS, AKT1, VEGFA, BAX, BIRC5, BCL2
29
Hide members
9.3FAS, AKT1, VEGFA, BAX, ESR1, BCL2
309.3AKT1, VEGFA, BAX, CYP19A1, ESR1, BCL2
319.2BCL2, FAS, AKT1, VEGFA, BAX, ESR1

Compounds for genes affiliated with Serous Cystadenocarcinoma

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Serous Cystadenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 195)
idCompoundScoreTop Affiliating Genes
1resveratrol44 59 11 2413.7PGR
2idoxifene4410.2CYP19A1, ESR1, PGR
3ponicidin4410.2BAX, BIRC5, BCL2
4estradiol benzoate4410.1PGR, ESR1, CYP19A1, ESR2
5nandrolone44 2411.1CYP19A1, PGR, ESR1, ESR2
6leuprolide acetate4410.1CYP19A1, PGR, ESR1, ESR2
7exemestane49 44 59 1113.1ESR1, PGR, CYP19A1, ESR2
8bisphenol a4410.1CYP19A1, PGR, ESR1, ESR2
9tanshinone iia4410.1FAS, BCL2, BAX
10lapatinib44 49 1112.1BIRC5, ESR1, PGR, CYP19A1
113,3-diindolylmethane4410.1VEGFA, BIRC5, ESR1, BAX
12clomiphene citrate4410.1PGR, ESR1, CYP19A1, ESR2
13hoechst 333424410.0FAS, BIRC5, BAX, BCL2
14fulvestrant44 49 28 1113.0PGR, ESR1, ESR2, CYP19A1
155fluorouracil4410.0FAS, BAX, PGR, BCL2, BIRC5
16letrozole44 49 59 1113.0CYP19A1, PGR, ESR2, ESR1
17toremifene44 1111.0CYP19A1, PGR, ESR1, ESR2, FAS
18levonorgestrel44 59 28 1113.0ESR2, ESR1, CYP19A1, PGR
194-hydroxytamoxifen449.9CYP19A1, ESR1, PGR, AKT1, ESR2
20noxa449.9BIRC5, BCL2, BAX, FAS
21indole-3-carbinol449.8BAX, AKT1, CYP19A1, BIRC5, ESR1, BCL2
22adriamycin449.8BIRC5, BCL2, PGR, BAX, AKT1, FAS
23gefitinib44 49 1111.8ESR1, CYP19A1, VEGFA, AKT1, BIRC5, ESR2
24celecoxib44 59 28 49 11 2414.8VEGFA, BAX, AKT1, CYP19A1, BCL2, BIRC5
25progestin449.8VEGFA, ESR1, PGR, CYP19A1, ESR2
26thymidylate449.8BIRC5, BAX, VEGFA, ESR2, FAS, BCL2
27taxane449.8VEGFA, CYP19A1, PGR, BIRC5, BCL2, ESR1
28gemcitabine44 49 1111.7BCL2, CYP19A1, BAX, VEGFA, AKT1, BIRC5
29trastuzumab44 49 1111.7BIRC5, ESR1, CYP19A1, VEGFA, PGR, FAS
30steroidal449.7ESR2, CYP19A1, ESR1, PGR
31etoposide44 49 59 1112.7BAX, ESR2, AKT1, FAS, BCL2
32dexamethasone44 49 28 1112.7FAS, BCL2, BIRC5, MUC16, VEGFA, AKT1
332-chlorodeoxyadenosine449.6FAS, BAX, BIRC5, BCL2
34mifepristone44 59 28 1112.6VEGFA, BAX, CYP19A1, PGR, BIRC5, ESR2
35arsenite44 2410.6FAS, VEGFA, BAX, AKT1, BCL2, BIRC5
36mg 13244 5910.6BIRC5, AKT1, ESR1, VEGFA, BAX, FAS
37docetaxel44 49 59 1112.6CYP19A1, PGR, BIRC5, VEGFA, BAX, BCL2
38ly294002449.5ESR1, BAX, VEGFA, AKT1, FAS, BIRC5
39actinomycin d449.4BCL2, ESR1, BIRC5, BAX, VEGFA, AKT1
40sb 20358044 5910.4BCL2, BAX, BIRC5, FAS, VEGFA, AKT1
41testosterone44 59 11 2412.3ESR2, AKT1, MUC16, CYP19A1, PGR, BIRC5
42cisplatin44 49 59 1112.2BCL2, BIRC5, MUC16, BAX, VEGFA, AKT1
43tamoxifen44 49 28 1112.1BCL2, ESR2, FAS, AKT1, VEGFA, CYP19A1
44genistein44 28 59 2 11 2414.1ESR2, BCL2, FAS, AKT1, VEGFA, BAX
45n acetylcysteine449.1BCL2, BIRC5, BAX, AKT1, FAS, VEGFA
46retinoic acid44 2410.0BIRC5, FAS, ESR2, AKT1, ESR1, PGR
47paraffin449.0AKT1, FAS, BAX, MUC16, PGR, VEGFA
48vegf449.0FAS, BCL2, ESR2, ESR1, BIRC5, PGR
49paclitaxel44 49 1111.0MUC16, FAS, BIRC5, BCL2, AKT1, BAX
50doxorubicin44 49 1110.8BCL2, VEGFA, PGR, ESR1, FAS, CYP19A1

GO Terms for genes affiliated with Serous Cystadenocarcinoma

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16Gene Ontology
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Cellular components related to Serous Cystadenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pore complexGO:04693010.1BCL2, BAX

Biological processes related to Serous Cystadenocarcinoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of nitrogen utilizationGO:00680810.4BAX, BCL2
2renal system processGO:00301410.4BCL2, FAS
3activation-induced cell death of T cellsGO:00692410.4AKT1, FAS
4regulation of protein heterodimerization activityGO:04349710.3BAX, BCL2
5regulation of protein homodimerization activityGO:04349610.3BAX, BCL2
6transformed cell apoptotic processGO:00692710.3FAS, BAX
7vagina developmentGO:06006810.3ESR2, ESR1, BAX
8neuron apoptotic processGO:05140210.2BCL2, BAX, FAS
9intrinsic apoptotic signaling pathwayGO:09719310.2BCL2, BAX, AKT1
10uterus developmentGO:06006510.2ESR1, ESR2
11positive regulation of peptidyl-serine phosphorylationGO:03313810.2AKT1, VEGFA, BCL2
12negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04315410.2AKT1, VEGFA, BIRC5
13positive regulation of nitric-oxide synthase activityGO:05100010.1ESR1, AKT1
14response to toxic substanceGO:00963610.1BCL2, BAX, FAS
15ovarian follicle developmentGO:00154110.0BCL2, ESR2, BAX, VEGFA
16positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.9ESR2, ESR1, AKT1
17response to acidGO:0011019.8BCL2, BAX
18positive regulation of apoptotic processGO:0430659.7FAS, AKT1, BAX, ESR2
19negative regulation of apoptotic processGO:0430669.7FAS, AKT1, VEGFA, BIRC5, BCL2

Molecular functions related to Serous Cystadenocarcinoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.3ESR2, ESR1
2BH3 domain bindingGO:05143410.2BCL2, BAX
3steroid bindingGO:00549610.1PGR, ESR1, ESR2
4estrogen receptor activityGO:03028410.1ESR1, ESR2
5core promoter sequence-specific DNA bindingGO:00104610.1ESR2, ESR1
6steroid hormone receptor activityGO:00370710.0ESR2, ESR1, PGR
7nitric-oxide synthase regulator activityGO:03023510.0ESR1, AKT1
8enzyme bindingGO:0198999.8ESR2, ESR1, BIRC5, PGR, AKT1
9channel activityGO:0152679.8BCL2, BAX
10identical protein bindingGO:0428029.1BCL2, FAS, USP2, AKT1, VEGFA, BAX
11protein bindingGO:0055157.0VEGFA, AKT1, USP2, USP14, FAS, UBE4A

Products for genes affiliated with Serous Cystadenocarcinoma

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Sources for Serous Cystadenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet