MCID: SRT001
MIFTS: 25

Sertoli Cell-Only Syndrome malady

Summaries for Sertoli Cell-Only Syndrome

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Sertoli cell-only syndrome (sco syndrome) is a condition of the testes that causes infertility in males due to having only sertoli cells (cells that nurture immature sperm) lining the seminiferous tubules (tubes inside the testicles where sperm develop). men typically learn they are affected between ages 20-40 when being evaluated for infertility and are found to have no sperm production (azoospermia). the diagnosis is made based on testicular biopsy findings. other signs and symptoms are rare, but are secondary to the underlying condition causing sco syndrome. most cases are idiopathic (of unknown cause), but causes may include deletions in the azoospermia factor (azf) region of the y chromosome, or y-chromosome microdeletions (referred to as y chromosome infertility); klinefelter syndrome; exposure to chemicals and toxins; history of radiation therapy; and history of severe trauma. there is not currently a known effective treatment for the condition. when no germ cells are visible in any seminiferous tubules it is considered sco type i; if germ cells are present in a minority of tubules is it considered sco type ii. last updated: 2/18/2011

MalaCards: Sertoli Cell-Only Syndrome, also known as del castillo syndrome, is related to azoospermia and klinefelter's syndrome. An important gene associated with Sertoli Cell-Only Syndrome is USP26 (ubiquitin specific peptidase 26).

Wikipedia:64 Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia ) is a disorder... more...

Description from OMIM:47 305700,400042

Aliases & Classifications for Sertoli Cell-Only Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 47OMIM, 61UMLS, 35MeSH
See all sources

Aliases & Descriptions:

sertoli cell-only syndrome 8 43 10
del castillo syndrome 8 43
germinal cell aplasia 8 43
congenital absence of germinal epithelium of testes 61
sertoli-cell-only syndrome 47


External Ids:

Disease Ontology8 DOID:0050457
MeSH35 D054331

Related Diseases for Sertoli Cell-Only Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of diseases related to Sertoli Cell-Only Syndrome:



Diseases related to sertoli cell-only syndrome

Clinical Features for Sertoli Cell-Only Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

305700,400042

Drugs & Therapeutics for Sertoli Cell-Only Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Sertoli Cell-Only Syndrome

Drug clinical trials:

Search ClinicalTrials for Sertoli Cell-Only Syndrome

Search NIH Clinical Center for Sertoli Cell-Only Syndrome

Search CenterWatch for Sertoli Cell-Only Syndrome

Genetic Tests for Sertoli Cell-Only Syndrome

Anatomical Context for Sertoli Cell-Only Syndrome

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Sertoli Cell-Only Syndrome:
id TissueAnatomical CompartmentCell Relevance
1 TestisSeminiferous TubulesSpermatogonial Stem Cells Affected by disease

Animal Models for Sertoli Cell-Only Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Sertoli Cell-Only Syndrome

Genetic Variations for Sertoli Cell-Only Syndrome

Expression for genes affiliated with Sertoli Cell-Only Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sertoli Cell-Only Syndrome

Search GEO for disease gene expression data for Sertoli Cell-Only Syndrome.

Pathways for genes affiliated with Sertoli Cell-Only Syndrome

Compounds for genes affiliated with Sertoli Cell-Only Syndrome

GO Terms for genes affiliated with Sertoli Cell-Only Syndrome

Sources:
16Gene Ontology
See all sources

Biological processes related to Sertoli Cell-Only Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein deubiquitinationGO:01657910.3USP26, USP9Y
2spermatogenesisGO:0072839.9DAZ2, USP9Y, DAZ1, SPATA9
3multicellular organismal developmentGO:0072759.7SPATA9, PROX2, DAZ1, DAZ2

Products for genes affiliated with Sertoli Cell-Only Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sertoli Cell-Only Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet