MCID: SRT002
MIFTS: 50

Sertoli Cell Tumor malady

Cancer category

Summaries for Sertoli Cell Tumor

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64Wikipedia, 33MalaCards
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Wikipedia:64 A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a Sex cord-gonadal stromal tumor of a... more...

MalaCards: Sertoli Cell Tumor, also known as tubular androblastoma nos, is related to peutz-jeghers syndrome and gynecomastia. An important gene associated with Sertoli Cell Tumor is INHA (inhibin, alpha), and among its related pathways are Nuclear Receptor transcription pathway and Ovarian Infertility Genes. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include ovary, kidney and lung, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Aliases & Classifications for Sertoli Cell Tumor

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

sertoli cell tumor 8 10 45 61
tubular androblastoma nos 8


External Ids:

Disease Ontology8 DOID:3577
NCIt40 C39976
MeSH35 D012707

Related Diseases for Sertoli Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Sertoli Cell Tumor family:

malignant sertoli cell tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome31.0INHA, CYP19A1, PRKAR1A
2gynecomastia30.6PGR, INHA, CYP19A1, CGB5, AR
3adenoma30.6ENO2, INHA, MUC1, NR5A1, SYP, PRKAR1A
4androgen insensitivity syndrome30.5AR
5gonadoblastoma30.5ALPP, WT1
6adenocarcinoma30.5ENO2, PGR, INHA, MUC1, NR5A1, SYP
7complete androgen insensitivity syndrome30.2CYP19A1, AR
8spindle cell sarcoma30.2MUC1, DES, VIM
9frasier syndrome30.2WT1
10neuroendocrine carcinoma30.2ENO2, MUC1, SYP
11cushing's syndrome30.2INHA, SYP, PRKAR1A
12pheochromocytoma30.2ENO2, INHA, NR5A1, SYP, CALB2
13sertoli-leydig cell tumor30.2PGR, INHA, MUC1, AFP, WT1, CALB2
14malignant sertoli cell tumor10.8
15peutz–jeghers syndrome10.7
16carney complex10.4
17spermatic cord torsion10.3
18mast-cell sarcoma10.1
19arteriovenous malformation10.1
20prostatic cyst10.1
21familial adenomatous polyposis10.1
22infant gynecomastia10.1
23alopecia10.1
24struma ovarii10.1
25testis seminoma10.1
26vagina sarcoma10.1
27precocious puberty10.1
28thyroid adenoma10.1
29ovarian malignant sertoli-leydig cell tumor10.1
30pancreatitis10.0ALPP
31cystadenoma10.0INHA
32thymoma10.0CALB2
33cystadenocarcinoma10.0MUC1
34syringoma10.0MUC1
35epithelioid trophoblastic tumor10.0INHA
36melanotic neuroectodermal tumor10.0SYP
37von hippel-lindau disease10.0INHA
38desmoid tumor10.0DES
39malignant peritoneal mesothelioma10.0CALB2
40cerebral primitive neuroectodermal tumor10.0ENO2
41colon adenocarcinoma10.0CALB2
42ductal carcinoma in situ10.0PGR
43premature ovarian failure10.0INHA
44epulis10.0ENO2
45leiomyomatosis10.0PGR
46rhabdoid cancer10.0ENO2
47omphalocele10.0AFP
48neurilemmoma10.0ENO2
49metanephric adenoma10.0WT1
50adrenocortical carcinoma10.0NR5A1

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to sertoli cell tumor

Clinical Features for Sertoli Cell Tumor

Drugs & Therapeutics for Sertoli Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Sertoli Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Sertoli Cell Tumor

Search NIH Clinical Center for Sertoli Cell Tumor

Search CenterWatch for Sertoli Cell Tumor

Genetic Tests for Sertoli Cell Tumor

Anatomical Context for Sertoli Cell Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Sertoli Cell Tumor:

33
Ovary, Kidney, Lung, Bone marrow, Skeletal muscle, Thyroid, Adrenal gland, Breast, Prostate, Testis, T cells, B cells, Testis germ, Testis leydig

Animal Models for Sertoli Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Sertoli Cell Tumor

Sources:
51PubMed
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Articles related to Sertoli Cell Tumor:

(show top 50)    (show all 300)
idTitleAuthorsYear
1
Weight reduction and pioglitazone ameliorate polycystic ovary syndrome after removal of a Sertoli-stromal cell tumor. (23226075)
2012
2
Sertoli cell tumor and gonadoblastoma in an untreated 29-year-old 46,XY phenotypic male with Frasier syndrome carrying a WT1 IVS9+4C>T mutation. (22908070)
2012
3
Malignant sertoli cell tumor in a goose (Anser cygnoides domesticus). (23397858)
2012
4
An unusual cause of infantile gynecomastia: sertoli cell tumor. (21358339)
2011
5
Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. (20587845)
2010
6
Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. (21170861)
2010
7
Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. (19289327)
2009
8
Testicular retiform Sertoli cell tumor: a problem in histopathologic diagnosis. (18417863)
2008
9
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
10
Interstitial cell tumor and Sertoli cell tumor in the testis of a cat. (17491086)
2007
11
Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases. (17255771)
2007
12
Primary amenorrhea in a young Polish woman with complete androgen insensitivity syndrome and Sertoli-Leydig cell tumor: identification of a new androgen receptor gene mutation and evidence of aromatase hyperactivity and apoptosis dysregulation within the tumor. (17852420)
2007
13
Carboplatin for treatment of a Sertoli cell tumor in a mallard (Anas platyrhynchos). (19754829)
2006
14
Ovarian Sertoli-Leydig cell tumor of intermediate grade with heterologous elements of rhabdomyosarcoma. A case report and a review of the literature. (16979522)
2006
15
A case of Sertoli-Leydig cell tumor in a postmenopausal woman. (16445673)
2006
16
Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus). (15872383)
2005
17
Pathologic quiz case: testicular pain and scrotal swelling in a 25-year-old man. Large cell calcifying Sertoli cell tumor of the testis. (15387684)
2004
18
Pathologic quiz case: incidental bilateral testicular nodules in an African American man. Large cell calcifying Sertoli cell tumor. (15086294)
2004
19
A case report of Sertoli cell tumor in a patient with testicular feminization: many dilemmas for the pathologist. (19753733)
2002
20
Utility of immunostaining for S-100 protein subunits in gonadal sex cord-stromal tumors, with emphasis on the large-cell calcifying Sertoli cell tumor of the testis. (11979368)
2002
21
Feminizing Sertoli cell tumor associated with Peutz-Jeghers syndrome. (12008693)
2002
22
Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. (11979085)
2002
23
Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor. (11381376)
2001
24
Ossifying well-differentiated Sertoli-Leydig cell tumor of the ovary. (10684379)
2000
25
Malignant Sertoli cell tumor of the ovary metastatic to the lung mimicking neuroendocrine carcinoma: report of a case. (10459047)
1999
26
Metastatic testicular Sertoli-cell tumor: cytopathologic findings on fine-needle aspiration. (9702492)
1998
27
Sertoli cell tumor of the testis. Report of a case with imprint cytology findings. (9850662)
1998
28
Testicular Sertoli cell tumor with a heterologous sarcomatous component: immunohistochemical assessment of Sertoli cell differentiation. (9786352)
1998
29
Large cell calcifying Sertoli cell tumor of the testis: contrasting features of six malignant and six benign tumors and a review of the literature. (9351565)
1997
30
Conservative management of Sertoli-Leydig cell tumor of the ovary. (9246972)
1997
31
Sertoli Cell Tumor of Testes in a Child with Peutz-Jeghers syndrome. (18417782)
1997
32
Ovarian serous cystadenoma associated with Sertoli-Leydig cell tumor--a case report. (8703377)
1996
33
Large cell calcifying Sertoli cell tumor of the testis. (8422009)
1993
34
Effects of interleukin-6, interleukin-2, and tumor necrosis factor alpha on transferrin release from Sertoli cells in culture. (1905226)
1991
35
Steroid biosynthesis in the Sertoli-Leydig cell tumor: effects of insulin and luteinizing hormone. (2532472)
1989
36
An unusual hormone pattern in a virilized woman affected by Sertoli-Leydig cell tumor. Report of a case. (2694756)
1989
37
Canine sertoli cell tumor: a medical records search and literature review. (17422824)
1987
38
Incipient germ cell tumor in Sertoli-cell-only syndrome testis, accompanied with retroperitoneal teratocarcinoma and widespread metastases. (3019076)
1986
39
Malignant Sertoli cell tumor of testicle. (4024415)
1985
40
Arrested puberty associated with a Sertoli-Leydig cell tumor. (4003476)
1985
41
Estrogen-producing Sertoli cell tumor of the ovary--a case report. (6500377)
1984
42
Large-cell calcifying Sertoli cell tumor of the testis: a case report with ultrastructural study. (6649081)
1983
43
Ovarian Sertoli-Leydig cell tumor with rhabdomyosarcoma: an ultrastructural study. (7157497)
1982
44
Malignant (androblastoma) Sertoli cell tumor of testes. (7281397)
1981
45
Ovarian Sertoli-Leydig cell tumor with hyperoestrinism. (6261444)
1981
46
Peutz-Jeghers syndrome with feminizing sertoli cell tumor. (6770991)
1980
47
Sertoli cell tumor in two related newborn shorthorn calves. (7459797)
1980
48
Sertoli cell tumor of testis. (442332)
1979
49
Sertoli-cell tumor: report of a case. (1206180)
1975
50
Metastasizing Sertoli-cell tumor (androblastoma). (5812721)
1969

Genetic Variations for Sertoli Cell Tumor

Expression for genes affiliated with Sertoli Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sertoli Cell Tumor

Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for genes affiliated with Sertoli Cell Tumor

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9PGR, NR5A1, AR
29.8PGR, INHA, CYP19A1, NR5A1

Compounds for genes affiliated with Sertoli Cell Tumor

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1butyrate4510.5CALB2
2estrogen4510.5NR5A1, CALB2
3reticulin4510.1MUC1, VIM, DES, SYP
4glutamate4510.0PRKAR1A, AMACR, AR
5s 1004510.0MUC1, SYP, DES, ENO2, VIM
6mucicarmine4510.0CALB2, VIM, MUC1, SYP, DES
7glycogen45 2411.0SYP, AFP, CGB5
8forskolin45 50 1112.0WT1, VIM, PRKAR1A, ENO2
9dihydrotestosterone45 29 11 2412.9VIM, DES, CYP19A1, PGR, CGB5
10clomiphene citrate459.9CGB5, PGR, CGB, AFP, CYP19A1
1117beta-hydroxysteroid459.8CYP19A1, AR, CGB5, NR5A1, PGR
12cycloheximide459.8ALPP, NR5A1, SOX9, CGB5
133beta-hydroxysteroid459.8CGB5, NR5A1, CYP19A1, INHA, PGR, AR
14etoposide45 50 60 1112.7AR, VIM, CGB5, CGB, AFP, WT1
15estrone45 29 11 2412.7CGB5, AR, AFP, NR5A1, CYP19A1, PGR
16creatinine459.7CGB5, AFP, CGB, WT1, ALPP, SYP
17formaldehyde45 2410.6SYP, DES, VIM, MUC1, ENO2, CYP19A1
18mifepristone45 60 29 1112.6AFP, MUC1, CYP19A1, PGR, CGB5, CGB
19dexamethasone45 50 29 1112.6ALPP, ENO2, AFP, AMACR, CGB5, AR
20silver459.5CALB2, DES, SYP, ENO2, AFP
21hyaluronic acid45 2410.5ENO2, MUC1, DES, WT1, VIM, CALB2
22diethylstilbestrol45 29 1111.5ENO2, CYP19A1, AR, NR5A1, AFP, PGR
23b 723459.5SYP, VIM, CALB2, WT1, DES, AFP
24folate459.4ALPP, AFP, MUC1, PGR, CGB5, VIM
25gnrh459.4VIM, AR, CGB, NR5A1, CYP19A1, INHA
26tamoxifen45 50 29 1112.4PGR, ALPP, VIM, AR, CGB5, MUC1
27progestin459.4PGR, MUC1, DES, CGB5, AR, VIM
28dmso459.4MUC1, ALPP, PGR, AFP, CGB5, VIM
29cysteine459.4AMACR, CGB, PRKAR1A, DES, SYP, MUC1
30doxorubicin45 50 1111.4CYP19A1, AFP, PGR, DES, CGB5, AR
31methotrexate45 50 1111.3ENO2, PGR, MUC1, AFP, CGB, CGB5
32serine459.3SOX9, DES, WT1, AFP, ALPP, NR5A1
33glutamine459.3VIM, AR, AFP, WT1, SYP, PGR
34androstenedione45 2410.2CYP19A1, AR, CGB5, CGB, INHA
35actinomycin d459.2DES, AFP, NR5A1, MUC1, VIM, AR
36ribonucleic acid459.2ENO2, MUC1, NR5A1, INHA, PGR, CGB5
37acth459.2ENO2, INHA, CGB5, SYP, NR5A1, MUC1
38vitamin d459.1PRKAR1A, AMACR, VIM, AFP, NR5A1, CYP19A1
39hematoxylin459.1SYP, MUC1, INHA, ENO2, VIM, AMACR
40thymidine45 2410.1ALPP, WT1, ENO2, NR5A1, MUC1, AFP
41cyclic amp45 2410.1NR5A1, CGB5, INHA, SOX9, MUC1, VIM
42lactate459.1ENO2, MLANA, AFP, DES, CGB5, CGB
43adenylate459.0VIM, AR, AMACR, CGB5, DES, NR5A1
44estradiol45 11 2410.9PGR, INHA, CYP19A1, MUC1, NR5A1, SYP
45vegf458.4DES, SYP, MUC1, PGR, ENO2, ALPP
46steroid458.3CALB2, SOX9, WT1, INHA, CYP19A1, NR5A1
47retinoic acid45 249.0ENO2, VIM, ALPP, CGB5, AMACR, SOX9
48progesterone45 60 29 11 2411.9CGB5, AR, WT1, CALB2, AMACR, VIM
49paraffin457.9VIM, AMACR, CALB2, WT1, AR, CGB5
50testosterone45 60 11 2410.4ENO2, PGR, INHA, CYP19A1, MUC1, NR5A1

GO Terms for genes affiliated with Sertoli Cell Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.7SYP, PRKAR1A, AR, SOX9

Biological processes related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tertiary branching involved in mammary gland duct morphogenesisGO:06074810.2AR, PGR
2negative regulation of female gonad developmentGO:200019510.2WT1, NR5A1
3prostate gland developmentGO:03085010.1AR, SOX9
4positive regulation of male gonad developmentGO:200002010.0SOX9, WT1, NR5A1
5prostate gland growthGO:06073610.0CYP19A1, AR
6ovulation from ovarian follicleGO:0015429.9AFP, PGR
7cell-cell signalingGO:0072679.8PGR, INHA, NR5A1, CGB, AR
8male gonad developmentGO:0085849.8INHA, NR5A1, AR, WT1, SOX9
9signal transductionGO:0071659.4PGR, INHA, PRKAR1A, CGB, AR, SOX9

Molecular functions related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.8PGR, NR5A1, AR
2receptor bindingGO:0051029.8PGR, INHA, AR, AMACR
3protein kinase A catalytic subunit bindingGO:0342369.7PRKAR1A, SOX9

Products for genes affiliated with Sertoli Cell Tumor

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  • Proteins
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Sources for Sertoli Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet