MCID: SRT002
MIFTS: 35

Sertoli Cell Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Sertoli Cell Tumor

MalaCards integrated aliases for Sertoli Cell Tumor:

Name: Sertoli Cell Tumor 12 52 42 14 69
Tubular Androblastoma Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3577
MeSH 42 D012707
NCIt 47 C39976
UMLS 69 C0036769

Summaries for Sertoli Cell Tumor

MalaCards based summary : Sertoli Cell Tumor, also known as tubular androblastoma nos, is related to seminoma and struma ovarii. An important gene associated with Sertoli Cell Tumor is SYP (Synaptophysin), and among its related pathways/superpathways is Ovarian Infertility Genes. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and endothelial, and related phenotype is normal.

Related Diseases for Sertoli Cell Tumor

Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
id Related Disease Score Top Affiliating Genes
1 seminoma 30.4 SYP WT1
2 struma ovarii 29.4 INHA MUC1 SYP
3 malignant sertoli cell tumor 12.2
4 carney complex, type 1 10.9
5 hairy palms and soles 10.6 CALB2 VIM
6 thymus lipoma 10.6 CALB2 WT1
7 skin glomus tumor 10.6 INHA VIM
8 malignant peritoneal solitary fibrous tumor 10.5 CALB2 WT1
9 cutaneous liposarcoma 10.5 CALB2 WT1
10 mesenteric vascular occlusion 10.5 CALB2 WT1
11 arteriolosclerosis 10.5 CALB2 WT1
12 neurogenic thoracic outlet syndrome 10.5 SYP VIM
13 plantar fasciitis 10.5 CALB2 WT1
14 skin papilloma 10.4 SYP VIM
15 nasal cavity squamous cell carcinoma 10.4 CALB2 WT1
16 adult medulloblastoma 10.4 SYP VIM
17 trachea sarcoma 10.4 CALB2 SYP
18 placental insufficiency 10.4 CALB2 SYP
19 axonal neuropathy 10.4 SYP VIM
20 behcet's syndrome arthropathy 10.4 SYP VIM
21 human t-cell leukemia virus type 1 10.4 CALB2 SYP
22 space motion sickness 10.4 SYP VIM
23 papillary glioneuronal tumor 10.4 SYP VIM
24 morbid obesity 10.4 INHA MUC1
25 basophilic carcinoma 10.4 SYP WT1
26 aflatoxins-related hepatocellular carcinoma 10.4 SYP VIM
27 idiopathic recurrent pericarditis 10.4 NR5A1 WT1
28 pleomorphic xanthoastrocytoma 10.4 SYP WT1
29 perivascular epithelioid cell tumor 10.4 CALB2 WT1
30 glomangioma 10.4 SYP VIM
31 chronic neutrophilic leukemia 10.4 CALB2 MUC1
32 mental retardation, autosomal recessive 50 10.4 INHA SYP
33 testicular trophoblastic tumor 10.4 CALB2 MUC1
34 small cell neuroendocrine carcinoma 10.4 CALB2 VIM
35 lynch syndrome 10.4 CALB2 SYP
36 myeloid/lymphoid neoplasm associated with pdgfra rearrangement 10.4 MUC1 VIM
37 spleen angiosarcoma 10.4 MUC1 VIM
38 myoma 10.4 MUC1 VIM
39 laryngeal neuroendocrine tumor 10.4 MUC1 VIM
40 mannose-binding lectin protein deficiency 10.3 MUC1 VIM
41 vulvar angiokeratoma 10.3 MUC1 VIM
42 noninvasive malignant thymoma 10.3 MUC1 VIM
43 pyoderma 10.3 MUC1 VIM
44 pancreatic intraductal papillary-colloid carcinoma 10.3 MUC1 VIM
45 bladder colloid adenocarcinoma 10.3 MUC1 VIM
46 cellular ependymoma 10.3 MUC1 VIM
47 lice infestation 10.3 MUC1 VIM
48 ganglioglioma 10.3 MUC1 VIM
49 diffuse meningeal melanocytosis 10.3 MUC1 VIM
50 childhood ovarian endodermal sinus tumor 10.3 SYP WT1

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to Sertoli Cell Tumor

Symptoms & Phenotypes for Sertoli Cell Tumor

MGI Mouse Phenotypes related to Sertoli Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 CALB2 INHA NR5A1 PRKAR1A SYP WT1

Drugs & Therapeutics for Sertoli Cell Tumor

Drugs for Sertoli Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
3
Bleomycin Approved Phase 2 11056-06-7 5360373
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Etoposide Approved Phase 2 33419-42-0 36462
6
Bevacizumab Approved, Investigational Phase 2 216974-75-3
7 Albumin-Bound Paclitaxel Phase 2
8 Antimitotic Agents Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2
10 Anti-Bacterial Agents Phase 2
11 Antibiotics, Antitubercular Phase 2
12 Etoposide phosphate Phase 2
13 Topoisomerase Inhibitors Phase 2
14 Angiogenesis Inhibitors Phase 2
15 Angiogenesis Modulating Agents Phase 2
16 Antibodies Phase 2
17 Antibodies, Monoclonal Phase 2
18 Endothelial Growth Factors Phase 2
19 Immunoglobulins Phase 2
20 Mitogens Phase 2
21
Gemcitabine Approved Phase 1 95058-81-4 60750
22 Anti-Infective Agents Phase 1
23 Antimetabolites Phase 1
24 Antimetabolites, Antineoplastic Phase 1
25 Antiviral Agents Phase 1
26 Immunosuppressive Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
4 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
5 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
6 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903
9 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Sertoli Cell Tumor

Cochrane evidence based reviews: sertoli cell tumor

Genetic Tests for Sertoli Cell Tumor

Anatomical Context for Sertoli Cell Tumor

MalaCards organs/tissues related to Sertoli Cell Tumor:

39
Testis, Ovary, Endothelial, Testes, Bone, Prostate, Lung

Publications for Sertoli Cell Tumor

Articles related to Sertoli Cell Tumor:

(show top 50) (show all 193)
id Title Authors Year
1
Bilateral Sertoli Cell Tumors in a Patient with Androgen Insensitivity Syndrome. ( 28386495 )
2017
2
An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report. ( 28276158 )
2017
3
Mayer-Rokitansky-KA1ster-Hauser Syndrome With Bilateral Ovarian Sertoli Cell Tumors: Review of the Literature and Report of a Rare Case. ( 28922305 )
2017
4
Unusual Sertoli Cell Tumor Associated With Sex Cord Tumor With Annular Tubules in Peutz-Jeghers Syndrome: Report of a Case and Review of the Literature on Ovarian Tumors in Peutz-Jeghers Syndrome. ( 26621753 )
2016
5
A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat. ( 26989303 )
2016
6
Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac. ( 27510681 )
2016
7
A CASE OF AN AROMATASE-PRODUCING SERTOLI CELL TUMOR PRESENTING WITH GYNECOMASTIA. ( 28442671 )
2016
8
RESPONSE TO THE ANASTROZOLE TREATMENT IN A CASE WITH PEUTZ-JEGHERS SYNDROME WHO WAS DETECTED TO HAVE LARGE CELL CALCIFYING SERTOLI CELL TUMOR AND DEVELOPED PRE-PUBERTAL GYNECOMASTIA. ( 27873740 )
2016
9
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report. ( 27488929 )
2016
10
LARGE CELL CALCIFYING SERTOLI CELL TUMOR OF THE TESTIS: A CASE REPORT. ( 28740051 )
2016
11
Management of an invasive and metastatic Sertoli cell tumor with associated myelotoxicosis in a dog. ( 26933269 )
2016
12
A Rare Cause of Prepubertal Gynecomastia: Sertoli Cell Tumor. ( 26366315 )
2015
13
Partial Orchiectomy for the Treatment of a Benign Sclerosing Sertoli Cell Tumor: A Report of a Rare Tumor in Association With Testicular Microlithiasis. ( 26793488 )
2015
14
What is your diagnosis? Cryptorchidism and Sertoli cell tumor. ( 25970213 )
2015
15
Isolated Large Cell Calcifying Sertoli Cell Tumor in a Young Boy, not Associated with Peutz-Jeghers Syndrome or Carney Complex. ( 26587565 )
2015
16
Nuclear Localization of I^-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases. ( 26034868 )
2015
17
Intratubular Large Cell Hyalinizing Sertoli Cell Tumor of the Testes in a 4-Year-Old Male With Peutz-Jeghers Syndrome. ( 25171448 )
2014
18
Melanotic Sertoli cell tumor. ( 25007144 )
2014
19
Large cell calcifying sertoli cell tumor of the testis: a case study and review of the literature. ( 24627695 )
2014
20
Use of Aromatase Inhibitors in Large Cell Calcifying Sertoli Cell Tumors: Effects on Gynecomastia, Growth Velocity, and Bone Age. ( 25226294 )
2014
21
Testicular sclerosing sertoli cell tumor: a case report and review of the literature. ( 25548547 )
2014
22
Frequent mutation and nuclear localization of I^-catenin in sertoli cell tumors of the testis. ( 24061522 )
2014
23
Sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases. ( 24552667 )
2014
24
Observations on the paper "sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases" by Kao et al. ( 25025367 )
2014
25
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. ( 23412916 )
2013
26
Sclerosing Sertoli cell tumor of the testis: a case report with review of the literature. ( 24228134 )
2013
27
Magnetic resonance imaging findings of sclerosing Sertoli cell tumor of the testis. ( 23329316 )
2013
28
Organ-sparing surgery of the bilateral testicular large cell calcifying sertoli cell tumor in patient with atypical Peutz-Jeghers syndrome. ( 22160729 )
2012
29
Pathology in practice: Sertoli cell tumor (SCT). ( 22720987 )
2012
30
Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: case report and literature review. ( 22226390 )
2012
31
Sertoli cell tumor and intratubular germ cell neoplasia located in separate gonads in an adolescent patient with complete androgen insensitivity: a case report and review of literature. ( 22876554 )
2012
32
Malignant sertoli cell tumor in a goose (Anser cygnoides domesticus). ( 23397858 )
2012
33
Bilateral Sertoli cell tumors of the testis-a likely new extracolonic manifestation of familial adenomatous polyposis. ( 23090627 )
2012
34
Malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome. ( 25191441 )
2012
35
Testicular sclerosing Sertoli cell tumor: an additional case and review of the literature. ( 23155292 )
2012
36
What is your diagnosis? Sertoli cell tumor with multiorgan metastasis. ( 23409440 )
2012
37
Sertoli cell tumor and gonadoblastoma in an untreated 29-year-old 46,XY phenotypic male with Frasier syndrome carrying a WT1 IVS9+4C>T mutation. ( 22908070 )
2012
38
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. ( 22705745 )
2012
39
An unusual cause of infantile gynecomastia: sertoli cell tumor. ( 21358339 )
2011
40
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. ( 20930104 )
2011
41
Spontaneous sertoli cell tumor with cryptorchism in a beagle dog. ( 21826179 )
2011
42
Pure Sertoli cell tumor. a case report and review of the literature. ( 20349797 )
2010
43
Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma. ( 20736766 )
2010
44
Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. ( 20587845 )
2010
45
Acute abdomen due to rupture of Sertoli cell tumor. ( 19597832 )
2010
46
[A case of sertoli cell tumor with arteriovenous malformation]. ( 20104012 )
2010
47
Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. ( 21170861 )
2010
48
Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. ( 20004940 )
2010
49
Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. ( 19553598 )
2009
50
A case of persistent MA1llerian duct syndrome with sertoli cell tumor and hydrometra in a dog. ( 19346713 )
2009

Variations for Sertoli Cell Tumor

Expression for Sertoli Cell Tumor

Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for Sertoli Cell Tumor

Pathways related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.13 INHA NR5A1

GO Terms for Sertoli Cell Tumor

Cellular components related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 9.16 CALB2 SYP
2 neuromuscular junction GO:0031594 8.96 PRKAR1A SYP
3 neuron projection GO:0043005 8.8 CALB2 SYP VIM

Biological processes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.43 INHA NR5A1 WT1
2 SMAD protein signal transduction GO:0060395 9.4 INHA VIM
3 adrenal gland development GO:0030325 9.37 NR5A1 WT1
4 tissue development GO:0009888 9.32 NR5A1 WT1
5 sex determination GO:0007530 9.16 NR5A1 WT1
6 positive regulation of male gonad development GO:2000020 8.96 NR5A1 WT1
7 negative regulation of female gonad development GO:2000195 8.62 NR5A1 WT1

Sources for Sertoli Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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