MCID: SRT002
MIFTS: 33

Sertoli Cell Tumor malady

Cancer diseases category

Aliases & Classifications for Sertoli Cell Tumor

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 42NCIt, 59SNOMED-CT
See all sources

Aliases & Descriptions for Sertoli Cell Tumor:

Name: Sertoli Cell Tumor 10 47 12 65 36
 
Tubular Androblastoma Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:3577
NCIt42 C39976
MeSH36 D012707

Summaries for Sertoli Cell Tumor

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MalaCards based summary: Sertoli Cell Tumor, also known as tubular androblastoma nos, is related to seminoma and peritonitis. An important gene associated with Sertoli Cell Tumor is INHA (Inhibin, Alpha). Affiliated tissues include testis, ovary and bone, and related mouse phenotypes are tumorigenesis and normal.

Related Diseases for Sertoli Cell Tumor

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Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.9AFP, SYP
2peritonitis30.6CALB2, WT1
3adenoma30.3CALB2, INHA, MUC1, VIM
4malignant sertoli cell tumor10.8
5peutz-jeghers syndrome10.8
6gynecomastia10.6
7androgen insensitivity10.5
8cryptorchidism10.4
9gonadoblastoma10.4
10adenocarcinoma10.4
11spermatic cord torsion10.3
12prostatitis10.3
13hypokalemia10.3CALB2, INHA
14haemophilus influenzae10.3CALB2, VIM
15fallopian tube adenofibroma10.3CALB2, INHA
16dysostosis10.2AFP, INHA
17ovarian serous adenofibroma10.2AFP, INHA
18hole retinal cyst10.2AFP, CALB2
19retinal artery occlusion10.2AFP, CALB2
20ovary neuroendocrine neoplasm10.2CALB2, WT1
21fallopian tube disease10.2CALB2, WT1
22steroid inherited metabolic disorder10.2AFP, VIM
23cervical verrucous carcinoma10.2INHA, VIM
24ovarian endometrioid adenofibroma10.2AFP, INHA
25acute frontal sinusitis10.2CALB2, WT1
26mucocele of appendix10.2CALB2, WT1
27krukenberg carcinoma10.2CALB2, WT1
28pleural empyema10.2CALB2, WT1
29testicular malignant germ cell cancer10.2AFP, WT1
30vulvar keratinizing squamous cell carcinoma10.2AFP, WT1
31pheochromocytoma10.2
32frasier syndrome10.2
33carney complex, type 110.2
34alopecia10.2
35familial adenomatous polyposis10.2
36prostatic cyst10.2
37cushing's syndrome10.2
38neuroendocrine carcinoma10.2
39arteriovenous malformation10.2
40mast-cell sarcoma10.2
41brucellosis10.2
42gastric adenocarcinoma10.2
43hermaphroditism10.2
44hypothyroidism10.2
45leydig cell tumor10.2
46prostate adenocarcinoma10.2
47renal adenoma10.2
48sarcoma10.2
49struma ovarii10.2
50thyroiditis10.2

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to sertoli cell tumor

Symptoms for Sertoli Cell Tumor

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Drugs & Therapeutics for Sertoli Cell Tumor

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Drugs for Sertoli Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GemcitabineapprovedPhase 1180095058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine Hydrochloride
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
2
CarboplatinapprovedPhase 1181241575-94-410339178, 498142, 38904, 38904, 498142
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)

Interventional clinical trials:

idNameStatusNCT IDPhase
1Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological CancerCompletedNCT01652794Phase 1
2Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast CancerCompletedNCT01764789
3DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History StudyRecruitingNCT01247597
4Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer SyndromeRecruitingNCT00565903
5International Ovarian & Testicular Stromal Tumor RegistryRecruitingNCT01970696
6Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal TumorsActive, not recruitingNCT01572467

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Cochrane evidence based reviews: Sertoli Cell Tumor

Genetic Tests for Sertoli Cell Tumor

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Anatomical Context for Sertoli Cell Tumor

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MalaCards organs/tissues related to Sertoli Cell Tumor:

33
Testis, Ovary, Bone, Testes, Prostate, Bone marrow, Lung

Animal Models for Sertoli Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Sertoli Cell Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1AFP, INHA, MUC1, PRKAR1A
2MP:00028737.7CALB2, INHA, MUC1, PRKAR1A, SYP, WT1
3MP:00053797.6AFP, INHA, MUC1, PRKAR1A, WT1
4MP:00053897.5AFP, INHA, PRKAR1A, VIM, WT1

Publications for Sertoli Cell Tumor

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Articles related to Sertoli Cell Tumor:

(show top 50)    (show all 178)
idTitleAuthorsYear
1
Observations on the paper "sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases" by Kao et al. (25025367)
2014
2
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. (23412916)
2013
3
Malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome. (25191441)
2012
4
Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. (20004940)
2010
5
Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. (20587845)
2010
6
Acute abdomen due to rupture of Sertoli cell tumor. (19597832)
2010
7
Case report of malignant sertoli cell tumor]. (18697473)
2008
8
Sertoli cell tumor of the testis: a case with late metastasis. (18500567)
2008
9
Benign large cell calcifying Sertoli cell tumor of the testis in a prepubescent patient. (17646440)
2007
10
Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of alpha-methylacyl-CoA racemase (AMACR/P504S). (17252229)
2007
11
Interstitial cell tumor and Sertoli cell tumor in the testis of a cat. (17491086)
2007
12
Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis. (18176022)
2007
13
A 67-year-old woman with abdominal distention, vaginal bleeding, and elevated CA 125 level. Pure Sertoli cell tumor of the ovary with differentiation varying from well-differentiated tubules, to intermediate foci, to sarcomatoid spindle cell areas. (16683900)
2006
14
Large cell calcifying Sertoli cell tumor of the testis in a boy with brucellosis. (16970792)
2006
15
Carboplatin for treatment of a Sertoli cell tumor in a mallard (Anas platyrhynchos). (19754829)
2006
16
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)
2005
17
Sertoli cell tumor of the testis in children: reevaluation of a rarely encountered tumor. (16189443)
2005
18
Sclerosing Sertoli cell tumor of the testis. (16197877)
2005
19
Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. (15943795)
2005
20
Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus). (15872383)
2005
21
Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. (15644771)
2005
22
Pathologic quiz case: testicular pain and scrotal swelling in a 25-year-old man. Large cell calcifying Sertoli cell tumor of the testis. (15387684)
2004
23
Simultaneous sertoli cell tumor and adenocarcinoma of the tunica vaginalis testis in a patient with testicular feminization. (11855889)
2002
24
A case report of Sertoli cell tumor in a patient with testicular feminization: many dilemmas for the pathologist. (19753733)
2002
25
Utility of immunostaining for S-100 protein subunits in gonadal sex cord-stromal tumors, with emphasis on the large-cell calcifying Sertoli cell tumor of the testis. (11979368)
2002
26
Sertoli cell proliferations of the infantile testis: an intratubular form of Sertoli cell tumor? (11688457)
2001
27
Pathological case of the month. Sertoli cell tumor. (10768686)
2000
28
Sclerosing sertoli cell tumor of the testis--a case report and review of the literature. (10452297)
1999
29
A case of large cell calcifying Sertoli cell tumor in a child with a history of nasal myxoid tumor in infancy. (10417694)
1999
30
Malignant large cell calcifying sertoli cell tumor with endocrine overactivity. (10210408)
1999
31
Malignant Sertoli cell tumor of the ovary metastatic to the lung mimicking neuroendocrine carcinoma: report of a case. (10459047)
1999
32
Metastatic testicular Sertoli-cell tumor: cytopathologic findings on fine-needle aspiration. (9702492)
1998
33
Sertoli cell tumor of the testis. Report of a case with imprint cytology findings. (9850662)
1998
34
Feminizing Sertoli cell tumors associated with Peutz-Jeghers syndrome: an increasingly recognized cause of prepubertal gynecomastia. (9734436)
1998
35
Sclerosing Sertoli cell tumor of the testis: a distinct histological subtype. (7563340)
1995
36
Carney's complex in a patient with hormone-producing Sertoli cell tumor of the testicle. (8411442)
1993
37
Fine needle aspiration cytology in malignant Sertoli cell tumor of the testis. A case report. (1636354)
1992
38
Large cell calcifying Sertoli cell tumor of the testis. A clinicopathologic, immunohistochemical, and ultrastructural study of two cases. (1746487)
1991
39
Fine needle aspiration cytology of a large cell calcifying Sertoli cell tumor of the testis. (3673461)
1987
40
Bone marrow hypoplasia in eight dogs with Sertoli cell tumor. (6113231)
1981
41
Malignant (androblastoma) Sertoli cell tumor of testes. (7281397)
1981
42
Gonadal stromal or sertoli cell tumor. (7052719)
1980
43
Peutz-Jeghers syndrome with feminizing sertoli cell tumor. (6770991)
1980
44
Sertoli cell tumor in two related newborn shorthorn calves. (7459797)
1980
45
Malignant androblastoma (Sertoli cell tumor) of the testis. A case report with a review of the literature. (167202)
1975
46
A sertoli-cell tumor in ectopic testicular tissue. (4747285)
1973
47
Malignant sertoli cell tumor of the testis. (5566364)
1971
48
Metastasizing Sertoli-cell tumor (androblastoma). (5812721)
1969
49
Androblastoma (Sertoli cell tumor): case report. (6057873)
1967
50
Sertoli cell tumor in an infant. (13346827)
1956

Variations for Sertoli Cell Tumor

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Expression for genes affiliated with Sertoli Cell Tumor

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Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for genes affiliated with Sertoli Cell Tumor

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GO Terms for genes affiliated with Sertoli Cell Tumor

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Cellular components related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:00430059.2CALB2, SYP, VIM

Biological processes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein signal transductionGO:00603958.9AFP, INHA, VIM

Sources for Sertoli Cell Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet