MCID: SRT002
MIFTS: 36

Sertoli Cell Tumor malady

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Sertoli Cell Tumor

Aliases & Descriptions for Sertoli Cell Tumor:

Name: Sertoli Cell Tumor 12 52 42 14 69
Tubular Androblastoma Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3577
MeSH 42 D012707
NCIt 47 C39976
UMLS 69 C0036769

Summaries for Sertoli Cell Tumor

MalaCards based summary : Sertoli Cell Tumor, also known as tubular androblastoma nos, is related to frasier syndrome and struma ovarii. An important gene associated with Sertoli Cell Tumor is SYP (Synaptophysin), and among its related pathways/superpathways is Ovarian Infertility Genes. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testes, and related phenotype is normal.

Related Diseases for Sertoli Cell Tumor

Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
id Related Disease Score Top Affiliating Genes
1 frasier syndrome 29.7 NR5A1 WT1
2 struma ovarii 29.5 INHA MUC1 SYP
3 malignant sertoli cell tumor 12.2
4 carney complex, type 1 10.9
5 peutz-jeghers syndrome 10.3
6 handigodu disease 10.2 CALB2 VIM
7 microphthalmia, syndromic 9 10.2 INHA SYP
8 jejunal neuroendocrine tumor 10.2 SYP VIM
9 hunter macpherson syndrome 10.2 CALB2 SYP
10 myxopapillary ependymoma 10.2 SYP VIM
11 adult central nervous system primitive neuroectodermal neoplasm 10.2 SYP VIM
12 nephrogenic adenoma of urinary bladder 10.2 SYP VIM
13 skin glomus tumor 10.2 INHA VIM
14 thymus lipoma 10.2 CALB2 WT1
15 trachea sarcoma 10.2 CALB2 SYP
16 male reproductive system disease 10.2 SYP VIM
17 hidrocystoma 10.2 CALB2 SYP
18 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.2 SYP VIM
19 adult pineal parenchymal tumor 10.2 SYP VIM
20 calcific tendinitis 10.2 SYP VIM
21 renal pelvis adenocarcinoma 10.2 SYP WT1
22 glomangioma 10.2 SYP VIM
23 gliofibroma 10.2 SYP WT1
24 persian gulf syndrome 10.2 CALB2 WT1
25 mucinous cystadenocarcinoma 10.2 INHA MUC1
26 motor neuron disease 10.2 INHA MUC1
27 hormone producing pituitary cancer 10.2 CALB2 WT1
28 gallbladder pleomorphic giant cell adenocarcinoma 10.2 SYP WT1
29 progressive multifocal leukoencephalopathy 10.2 VIM WT1
30 liver angiosarcoma 10.2 VIM WT1
31 mesenteric vascular occlusion 10.2 CALB2 WT1
32 skeletal-extraskeletal angiomatosis 10.2 MUC1 SYP
33 trophoblastic neoplasm 10.2 CALB2 MUC1
34 prolactin producing pituitary tumor 10.2 MUC1 SYP
35 placental insufficiency 10.2 CALB2 SYP
36 vaginal endometrial stromal sarcoma 10.1 CALB2 WT1
37 myoma 10.1 MUC1 VIM
38 immunodeficiency due to a classical component pathway complement deficiency 10.1 MUC1 VIM
39 spleen angiosarcoma 10.1 MUC1 VIM
40 marfanoid hypermobility syndrome 10.1 MUC1 VIM
41 pelvic inflammatory disease 10.1 MUC1 SYP
42 biliary papillomatosis 10.1 MUC1 VIM
43 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.1 MUC1 VIM
44 endometrial stromal sarcoma 10.1 MUC1 VIM
45 tanycytic ependymoma 10.1 MUC1 VIM
46 subglottis verrucous carcinoma 10.1 MUC1 VIM
47 bladder adenocarcinoma 10.1 MUC1 VIM
48 conjunctival cancer 10.1 MUC1 VIM
49 clear cell ependymoma 10.1 MUC1 VIM
50 sternum cancer 10.1 MUC1 VIM

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to Sertoli Cell Tumor

Symptoms & Phenotypes for Sertoli Cell Tumor

MGI Mouse Phenotypes related to Sertoli Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 WT1 CALB2 INHA NR5A1 PRKAR1A SYP

Drugs & Therapeutics for Sertoli Cell Tumor

Drugs for Sertoli Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
3
Bleomycin Approved Phase 2 11056-06-7 5360373
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Etoposide Approved Phase 2 33419-42-0 36462
6
Succinylcholine Approved Phase 2 306-40-1 5314
7
Bevacizumab Approved, Investigational Phase 2 216974-75-3
8 Albumin-Bound Paclitaxel Phase 2
9 Antimitotic Agents Phase 2
10 Antineoplastic Agents, Phytogenic Phase 2
11 Anti-Bacterial Agents Phase 2
12 Antibiotics, Antitubercular Phase 2
13 Etoposide phosphate Phase 2
14 Neuromuscular Agents Phase 2
15 Neuromuscular Blocking Agents Phase 2
16 Neuromuscular Depolarizing Agents Phase 2
17 Peripheral Nervous System Agents Phase 2
18 Topoisomerase Inhibitors Phase 2
19 Angiogenesis Inhibitors Phase 2
20 Angiogenesis Modulating Agents Phase 2
21 Antibodies Phase 2
22 Antibodies, Monoclonal Phase 2
23 Endothelial Growth Factors Phase 2
24 Immunoglobulin G Phase 2
25 Immunoglobulins Phase 2
26 Mitogens Phase 2
27
Gemcitabine Approved Phase 1 95058-81-4 60750
28 Anti-Infective Agents Phase 1
29 Antimetabolites Phase 1
30 Antimetabolites, Antineoplastic Phase 1
31 Antiviral Agents Phase 1
32 Immunosuppressive Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
4 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1
5 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
6 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903
9 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Sertoli Cell Tumor

Cochrane evidence based reviews: sertoli cell tumor

Genetic Tests for Sertoli Cell Tumor

Anatomical Context for Sertoli Cell Tumor

MalaCards organs/tissues related to Sertoli Cell Tumor:

39
Testis, Ovary, Testes, Bone, Lung, Bone Marrow, Prostate

Publications for Sertoli Cell Tumor

Articles related to Sertoli Cell Tumor:

(show top 50) (show all 189)
id Title Authors Year
1
Bilateral Sertoli Cell Tumors in a Patient with Androgen Insensitivity Syndrome. ( 28386495 )
2017
2
A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat. ( 26989303 )
2016
3
Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac. ( 27510681 )
2016
4
RESPONSE TO THE ANASTROZOLE TREATMENT IN A CASE WITH PEUTZ-JEGHERS SYNDROME WHO WAS DETECTED TO HAVE LARGE CELL CALCIFYING SERTOLI CELL TUMOR AND DEVELOPED PRE-PUBERTAL GYNECOMASTIA. ( 27873740 )
2016
5
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report. ( 27488929 )
2016
6
Unusual Sertoli Cell Tumor Associated With Sex Cord Tumor With Annular Tubules in Peutz-Jeghers Syndrome: Report of a Case and Review of the Literature on Ovarian Tumors in Peutz-Jeghers Syndrome. ( 26621753 )
2016
7
Management of an invasive and metastatic Sertoli cell tumor with associated myelotoxicosis in a dog. ( 26933269 )
2016
8
Isolated Large Cell Calcifying Sertoli Cell Tumor in a Young Boy, not Associated with Peutz-Jeghers Syndrome or Carney Complex. ( 26587565 )
2015
9
A Rare Cause of Prepubertal Gynecomastia: Sertoli Cell Tumor. ( 26366315 )
2015
10
What is your diagnosis? Cryptorchidism and Sertoli cell tumor. ( 25970213 )
2015
11
Nuclear Localization of I^-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases. ( 26034868 )
2015
12
Partial Orchiectomy for the Treatment of a Benign Sclerosing Sertoli Cell Tumor: A Report of a Rare Tumor in Association With Testicular Microlithiasis. ( 26793488 )
2015
13
Intratubular Large Cell Hyalinizing Sertoli Cell Tumor of the Testes in a 4-Year-Old Male With Peutz-Jeghers Syndrome. ( 25171448 )
2014
14
Testicular sclerosing sertoli cell tumor: a case report and review of the literature. ( 25548547 )
2014
15
Use of Aromatase Inhibitors in Large Cell Calcifying Sertoli Cell Tumors: Effects on Gynecomastia, Growth Velocity, and Bone Age. ( 25226294 )
2014
16
Observations on the paper "sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases" by Kao et al. ( 25025367 )
2014
17
Large cell calcifying sertoli cell tumor of the testis: a case study and review of the literature. ( 24627695 )
2014
18
Melanotic Sertoli cell tumor. ( 25007144 )
2014
19
Sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases. ( 24552667 )
2014
20
Frequent mutation and nuclear localization of I^-catenin in sertoli cell tumors of the testis. ( 24061522 )
2014
21
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. ( 23412916 )
2013
22
Magnetic resonance imaging findings of sclerosing Sertoli cell tumor of the testis. ( 23329316 )
2013
23
Sclerosing Sertoli cell tumor of the testis: a case report with review of the literature. ( 24228134 )
2013
24
Sertoli cell tumor and intratubular germ cell neoplasia located in separate gonads in an adolescent patient with complete androgen insensitivity: a case report and review of literature. ( 22876554 )
2012
25
What is your diagnosis? Sertoli cell tumor with multiorgan metastasis. ( 23409440 )
2012
26
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. ( 22705745 )
2012
27
Bilateral Sertoli cell tumors of the testis-a likely new extracolonic manifestation of familial adenomatous polyposis. ( 23090627 )
2012
28
Testicular sclerosing Sertoli cell tumor: an additional case and review of the literature. ( 23155292 )
2012
29
Organ-sparing surgery of the bilateral testicular large cell calcifying sertoli cell tumor in patient with atypical Peutz-Jeghers syndrome. ( 22160729 )
2012
30
Sertoli cell tumor and gonadoblastoma in an untreated 29-year-old 46,XY phenotypic male with Frasier syndrome carrying a WT1 IVS9+4C>T mutation. ( 22908070 )
2012
31
Malignant sertoli cell tumor in a goose (Anser cygnoides domesticus). ( 23397858 )
2012
32
Malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome. ( 25191441 )
2012
33
Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: case report and literature review. ( 22226390 )
2012
34
Pathology in practice: Sertoli cell tumor (SCT). ( 22720987 )
2012
35
An unusual cause of infantile gynecomastia: sertoli cell tumor. ( 21358339 )
2011
36
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. ( 20930104 )
2011
37
Spontaneous sertoli cell tumor with cryptorchism in a beagle dog. ( 21826179 )
2011
38
Acute abdomen due to rupture of Sertoli cell tumor. ( 19597832 )
2010
39
Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma. ( 20736766 )
2010
40
Pure Sertoli cell tumor. a case report and review of the literature. ( 20349797 )
2010
41
Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. ( 21170861 )
2010
42
Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. ( 20004940 )
2010
43
Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. ( 20587845 )
2010
44
[A case of sertoli cell tumor with arteriovenous malformation]. ( 20104012 )
2010
45
A case of persistent MA1llerian duct syndrome with sertoli cell tumor and hydrometra in a dog. ( 19346713 )
2009
46
Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. ( 19553598 )
2009
47
Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. ( 19255517 )
2009
48
Sertoli cell tumor of the testis: a case with late metastasis. ( 18500567 )
2008
49
Testicular retiform Sertoli cell tumor: a problem in histopathologic diagnosis. ( 18417863 )
2008
50
SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor. ( 18753972 )
2008

Variations for Sertoli Cell Tumor

Expression for Sertoli Cell Tumor

Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for Sertoli Cell Tumor

Pathways related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.13 INHA NR5A1

GO Terms for Sertoli Cell Tumor

Cellular components related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neuromuscular junction GO:0031594 8.96 PRKAR1A SYP
2 neuron projection GO:0043005 8.8 CALB2 SYP VIM

Biological processes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.43 INHA NR5A1 WT1
2 SMAD protein signal transduction GO:0060395 9.4 INHA VIM
3 adrenal gland development GO:0030325 9.37 NR5A1 WT1
4 tissue development GO:0009888 9.32 NR5A1 WT1
5 sex determination GO:0007530 9.16 NR5A1 WT1
6 positive regulation of male gonad development GO:2000020 8.96 NR5A1 WT1
7 negative regulation of female gonad development GO:2000195 8.62 NR5A1 WT1

Sources for Sertoli Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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