MCID: SRT002
MIFTS: 54

Sertoli Cell Tumor malady

Cancer diseases category

Summaries for Sertoli Cell Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a Sex cord-gonadal stromal tumor of a... more...

MalaCards: Sertoli Cell Tumor, also known as tubular androblastoma nos, is related to peutz-jeghers syndrome and seminoma. An important gene associated with Sertoli Cell Tumor is INHA (inhibin, alpha), and among its related pathways are Nuclear Receptor transcription pathway and Ovarian Infertility Genes. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testes, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Aliases & Classifications for Sertoli Cell Tumor

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

sertoli cell tumor 8 10 44 60
tubular androblastoma nos 8


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Disease Ontology8 DOID:3577
NCIt39 C39976
MeSH34 D012707

Related Diseases for Sertoli Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome30.9INHA, CYP19A1, PRKAR1A
2seminoma30.6ALPP, ENO2, INHA, AFP, CGB, CGB5
3gynecomastia30.6PGR, INHA, CYP19A1, CGB5, AR
4androgen insensitivity syndrome30.5AR
5gonadoblastoma30.5ALPP, WT1
6cryptorchidism30.5ALPP, CYP19A1, NR5A1, CGB5, AR, WT1
7adenoma30.5ENO2, INHA, MUC1, NR5A1, SYP, PRKAR1A
8adenocarcinoma30.4ENO2, PGR, INHA, MUC1, NR5A1, SYP
9frasier syndrome30.1WT1
10neuroendocrine carcinoma30.1ENO2, MUC1, SYP
11cushing's syndrome30.1INHA, SYP, PRKAR1A
12leydig cell tumor30.1INHA, CYP19A1, NR5A1, CGB5, CALB2
13pheochromocytoma30.1ENO2, INHA, NR5A1, SYP, CALB2
14sarcoma30.1ENO2, MUC1, DES, MLANA, CGB, CGB5
15malignant sertoli cell tumor10.8
16carney complex10.3
17spermatic cord torsion10.3
18neuroendocrine tumor10.3
19prostatitis10.3
20mast-cell sarcoma10.1
21arteriovenous malformation10.1
22prostatic cyst10.1
23familial adenomatous polyposis10.1
24alopecia10.1
25brucellosis10.1
26gastric adenocarcinoma10.1
27hair disease10.1
28hermaphroditism10.1
29hypertension10.1
30hypothyroidism10.1
31peritonitis10.1
32prostate adenocarcinoma10.1
33renal adenoma10.1
34struma ovarii10.1
35testis seminoma10.1
36thyroiditis10.1
37vaginitis10.1
38image syndrome10.1
39ovarian malignant sertoli-leydig cell tumor10.1
40pancreatitis10.0ALPP
41cystadenoma10.0INHA
42thymoma10.0CALB2
43cystadenocarcinoma10.0MUC1
44syringoma10.0MUC1
45epithelioid trophoblastic tumor10.0INHA
46melanotic neuroectodermal tumor10.0SYP
47von hippel-lindau disease10.0INHA
48desmoid tumor10.0DES
49malignant peritoneal mesothelioma10.0CALB2
50cerebral primitive neuroectodermal tumor10.0ENO2

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to sertoli cell tumor

Clinical Features for Sertoli Cell Tumor

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Drugs & Therapeutics for Sertoli Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sertoli Cell Tumor

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Anatomical Context for Sertoli Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Sertoli Cell Tumor:

32
Testis, Ovary, Testes, Prostate, Bone marrow, Bone, Lung, Breast, Kidney, Skeletal muscle, Thyroid

Animal Models for Sertoli Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sertoli Cell Tumor:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2INHA, AFP, WT1
2MP:00053699.8SOX9, WT1, PRKAR1A, CYP19A1
3MP:00053899.8WT1, PRKAR1A, AFP, NR5A1, INHA
4MP:00053709.4INHA, CYP19A1, MUC1, AR, WT1, AMACR
5MP:00053769.2AMACR, SOX9, AR, PRKAR1A, DES, AFP
6MP:00020069.2AR, PRKAR1A, AFP, MUC1, INHA, PGR
7MP:00053808.9VIM, SOX9, WT1, AR, PRKAR1A, NR5A1
8MP:00053858.8VIM, SOX9, WT1, AR, PRKAR1A, DES
9MP:00053868.6VIM, CALB2, SOX9, AR, DES, AFP
10MP:00028738.4ALPP, CALB2, SOX9, WT1, AR, PRKAR1A
11MP:00053788.4VIM, AMACR, SOX9, WT1, AR, PRKAR1A
12MP:00107688.3VIM, AMACR, SOX9, WT1, AR, PRKAR1A

Publications for Sertoli Cell Tumor

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50PubMed
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Articles related to Sertoli Cell Tumor:

(show top 50)    (show all 300)
idTitleAuthorsYear
1
Magnetic resonance imaging findings of sclerosing Sertoli cell tumor of the testis. (23329316)
2013
2
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. (22691037)
2013
3
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. (23173550)
2013
4
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
5
Sertoli cell tumor and gonadoblastoma in an untreated 29-year-old 46,XY phenotypic male with Frasier syndrome carrying a WT1 IVS9+4C>T mutation. (22908070)
2012
6
What is your diagnosis? Sertoli cell tumor with multiorgan metastasis. (23409440)
2012
7
Sertoli cell tumor and intratubular germ cell neoplasia located in separate gonads in an adolescent patient with complete androgen insensitivity: a case report and review of literature. (22876554)
2012
8
The case reported as bilateral Sertoli-Leydig cell tumors in a 61-year-old woman with uterine aplasia may instead represent complete androgen insensitivity syndrome. (21623193)
2011
9
Spontaneous sertoli cell tumor with cryptorchism in a beagle dog. (21826179)
2011
10
Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case report. (20736765)
2010
11
Case report of malignant sertoli cell tumor]. (18697473)
2008
12
Sertoli-Leydig cell tumor of the testis in a Sprague-Dawley rat. (19049257)
2008
13
SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor. (18753972)
2008
14
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
15
Benign large cell calcifying Sertoli cell tumor of the testis in a prepubescent patient. (17646440)
2007
16
Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of alpha-methylacyl-CoA racemase (AMACR/P504S). (17252229)
2007
17
Interstitial cell tumor and Sertoli cell tumor in the testis of a cat. (17491086)
2007
18
Large cell calcifying Sertoli cell tumor of testis. (17509353)
2007
19
Ovarian Sertoli-Leydig cell tumor of intermediate grade with heterologous elements of rhabdomyosarcoma. A case report and a review of the literature. (16979522)
2006
20
Sertoli cell tumor of the testis in children: reevaluation of a rarely encountered tumor. (16189443)
2005
21
Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus). (15872383)
2005
22
Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. (15644771)
2005
23
Ovarian Sertoli-Leydig cell tumor with coexisting vaginal angiomyxoma: case report and review of the literature. (15053079)
2004
24
Sertoli Leydig cell tumor with heterologous gastrointestinal epithelium: a case report. (15027740)
2003
25
Ovarian Sertoli-Leydig cell tumor of intermediate differentiation with immature skeletal muscle heterologous elements. (12648187)
2003
26
PET imaging of Sertoli cell tumor in androgen insensitivity syndrome. (12972996)
2003
27
A case report of Sertoli cell tumor in a patient with testicular feminization: many dilemmas for the pathologist. (19753733)
2002
28
Sertoli cell tumor in a prepubertal boy mimicking testicular torsion. (11112872)
2000
29
Metastatic testicular Sertoli-cell tumor: cytopathologic findings on fine-needle aspiration. (9702492)
1998
30
Testicular Sertoli cell tumor with a heterologous sarcomatous component: immunohistochemical assessment of Sertoli cell differentiation. (9786352)
1998
31
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor. (9345364)
1997
32
Sertoli Leydig cell tumor with malignant heterologous elements and raised alpha-fetoprotein: a case report. (9037950)
1996
33
Nuclear bodies appearance rate in canine testicular Sertoli cell tumor. (7757954)
1995
34
Bilateral asynchronous Sertoli cell tumor in a boy with the Peutz-Jeghers syndrome. (8072115)
1994
35
Sertoli-Leydig cell tumor of the ovary: a rare cause of amenorrhea. (1565381)
1992
36
Canine sertoli cell tumor: a medical records search and literature review. (17422824)
1987
37
Bilateral Sertoli-Leydig cell tumor with heterologous elements: report of an unusual case and review of the literature. (3732587)
1986
38
Incipient germ cell tumor in Sertoli-cell-only syndrome testis, accompanied with retroperitoneal teratocarcinoma and widespread metastases. (3019076)
1986
39
Malignant Sertoli cell tumor of testicle. (4024415)
1985
40
Estrogen-producing Sertoli cell tumor of the ovary--a case report. (6500377)
1984
41
Large-cell calcifying sertoli cell tumor of the testis. An ultrastructural, immunocytochemical, and biochemical study. (6850507)
1983
42
Sertoli-Leydig cell tumor of the ovary with heterologous elements and carcinoid: an immunohistochemical and ultrastructural study. (6367176)
1983
43
Prostatic adenocarcinoma with concurrent Sertoli cell tumor in a dog. (7340923)
1981
44
Pyometra and a Sertoli cell tumor in a hermaphroditic dog. (260864)
1979
45
Light and electron microscopic study of an intermediate sertoli-leydig cell tumor with a review of literatures in Japan. (1026031)
1976
46
Malignant androblastoma (Sertoli cell tumor) of the testis. A case report with a review of the literature. (167202)
1975
47
Sertoli cell tumor of testis in childhood. (4415735)
1974
48
A sertoli-cell tumor in ectopic testicular tissue. (4747285)
1973
49
Ultrastructure of a virilizing ovarian sertoli-leydig cell. Tumor with familial incidence. (4709959)
1973
50
Ultrastructure of ovarian stromal cell tumors. Sertoli-Leydig cell tumor and lipid cell tumor. (5681434)
1968

Genetic Variations for Sertoli Cell Tumor

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Expression for genes affiliated with Sertoli Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sertoli Cell Tumor

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Pathways for genes affiliated with Sertoli Cell Tumor

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9PGR, NR5A1, AR
29.8PGR, INHA, CYP19A1, NR5A1

Compounds for genes affiliated with Sertoli Cell Tumor

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5CALB2
2estrogen4410.5NR5A1, CALB2
3reticulin4410.1MUC1, VIM, DES, SYP
4glutamate4410.0PRKAR1A, AMACR, AR
5s 1004410.0MUC1, SYP, DES, ENO2, VIM
6mucicarmine4410.0CALB2, VIM, MUC1, SYP, DES
7glycogen44 2411.0SYP, AFP, CGB5
8forskolin44 49 1112.0WT1, VIM, PRKAR1A, ENO2
9dihydrotestosterone44 28 11 2412.9VIM, DES, CYP19A1, PGR, CGB5
10clomiphene citrate449.9CGB5, PGR, CGB, AFP, CYP19A1
1117beta-hydroxysteroid449.8CYP19A1, AR, CGB5, NR5A1, PGR
12cycloheximide449.8ALPP, NR5A1, SOX9, CGB5
133beta-hydroxysteroid449.8CGB5, NR5A1, CYP19A1, INHA, PGR, AR
14etoposide44 49 59 1112.7AR, VIM, CGB5, CGB, AFP, WT1
15estrone44 28 11 2412.7CGB5, AR, AFP, NR5A1, CYP19A1, PGR
16creatinine449.7CGB5, AFP, CGB, WT1, ALPP, SYP
17formaldehyde44 2410.6SYP, DES, VIM, MUC1, ENO2, CYP19A1
18mifepristone44 59 28 1112.6AFP, MUC1, CYP19A1, PGR, CGB5, CGB
19dexamethasone44 49 28 1112.6ALPP, ENO2, AFP, AMACR, CGB5, AR
20silver449.5CALB2, DES, SYP, ENO2, AFP
21hyaluronic acid44 2410.5ENO2, MUC1, DES, WT1, VIM, CALB2
22diethylstilbestrol44 28 1111.5ENO2, CYP19A1, AR, NR5A1, AFP, PGR
23b 723449.5SYP, VIM, CALB2, WT1, DES, AFP
24folate449.4ALPP, AFP, MUC1, PGR, CGB5, VIM
25gnrh449.4VIM, AR, CGB, NR5A1, CYP19A1, INHA
26tamoxifen44 49 28 1112.4PGR, ALPP, VIM, AR, CGB5, MUC1
27progestin449.4PGR, MUC1, DES, CGB5, AR, VIM
28dmso449.4MUC1, ALPP, PGR, AFP, CGB5, VIM
29cysteine449.4AMACR, CGB, PRKAR1A, DES, SYP, MUC1
30doxorubicin44 49 1111.4CYP19A1, AFP, PGR, DES, CGB5, AR
31methotrexate44 49 1111.3ENO2, PGR, MUC1, AFP, CGB, CGB5
32serine449.3SOX9, DES, WT1, AFP, ALPP, NR5A1
33glutamine449.3VIM, AR, AFP, WT1, SYP, PGR
34androstenedione44 2410.2CYP19A1, AR, CGB5, CGB, INHA
35actinomycin d449.2DES, AFP, NR5A1, MUC1, VIM, AR
36ribonucleic acid449.2ENO2, MUC1, NR5A1, INHA, PGR, CGB5
37acth449.2ENO2, INHA, CGB5, SYP, NR5A1, MUC1
38vitamin d449.1PRKAR1A, AMACR, VIM, AFP, NR5A1, CYP19A1
39hematoxylin449.1SYP, MUC1, INHA, ENO2, VIM, AMACR
40thymidine44 2410.1ALPP, WT1, ENO2, NR5A1, MUC1, AFP
41cyclic amp44 2410.1NR5A1, CGB5, INHA, SOX9, MUC1, VIM
42lactate449.1ENO2, MLANA, AFP, DES, CGB5, CGB
43adenylate449.0VIM, AR, AMACR, CGB5, DES, NR5A1
44estradiol44 11 2410.9PGR, INHA, CYP19A1, MUC1, NR5A1, SYP
45vegf448.4DES, SYP, MUC1, PGR, ENO2, ALPP
46steroid448.3CALB2, SOX9, WT1, INHA, CYP19A1, NR5A1
47retinoic acid44 249.0ENO2, VIM, ALPP, CGB5, AMACR, SOX9
48progesterone44 59 28 11 2411.9CGB5, AR, WT1, CALB2, AMACR, VIM
49paraffin447.9VIM, AMACR, CALB2, WT1, AR, CGB5
50testosterone44 59 11 2410.4ENO2, PGR, INHA, CYP19A1, MUC1, NR5A1

GO Terms for genes affiliated with Sertoli Cell Tumor

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16Gene Ontology
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Cellular components related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.7SYP, PRKAR1A, AR, SOX9

Biological processes related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tertiary branching involved in mammary gland duct morphogenesisGO:06074810.2AR, PGR
2negative regulation of female gonad developmentGO:200019510.2WT1, NR5A1
3prostate gland developmentGO:03085010.1AR, SOX9
4positive regulation of male gonad developmentGO:200002010.0SOX9, WT1, NR5A1
5prostate gland growthGO:06073610.0CYP19A1, AR
6ovulation from ovarian follicleGO:0015429.9AFP, PGR
7cell-cell signalingGO:0072679.8PGR, INHA, NR5A1, CGB, AR
8male gonad developmentGO:0085849.8INHA, NR5A1, AR, WT1, SOX9
9signal transductionGO:0071659.4PGR, INHA, PRKAR1A, CGB, AR, SOX9

Molecular functions related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.8PGR, NR5A1, AR
2receptor bindingGO:0051029.8PGR, INHA, AR, AMACR
3protein kinase A catalytic subunit bindingGO:0342369.7PRKAR1A, SOX9

Products for genes affiliated with Sertoli Cell Tumor

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Sources for Sertoli Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet