MCID: SRT002
MIFTS: 33

Sertoli Cell Tumor malady

Cancer diseases category

Summaries for Sertoli Cell Tumor

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MalaCards based summary: Sertoli Cell Tumor, also known as tubular androblastoma nos, is related to seminoma and leydig cell tumor. An important gene associated with Sertoli Cell Tumor is INHA (inhibin, alpha). The compounds ganglioside and nad+ have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testes, and related mouse phenotype tumorigenesis.

Aliases & Classifications for Sertoli Cell Tumor

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt
See all sources

Sertoli Cell Tumor, Aliases & Descriptions:

Name: Sertoli Cell Tumor 9 11 43 60
 
Tubular Androblastoma Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:3577
MeSH33 D012707
NCIt38 C39976

Related Diseases for Sertoli Cell Tumor

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Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.9AFP, INHA
2leydig cell tumor30.9INHA
3cushing's syndrome30.5SYP, INHA
4adenoma30.3INHA, MUC1, SYP
5pheochromocytoma30.1SYP, INHA
6adenocarcinoma30.0SYP, MUC1, AFP, INHA
7malignant sertoli cell tumor10.8
8peutz-jeghers syndrome10.8
9gynecomastia10.5
10androgen insensitivity10.5
11cryptorchidism10.4
12gonadoblastoma10.4
13spermatic cord torsion10.3
14prostatitis10.3
15fibrous meningioma10.3MUC1
16syringoma10.3MUC1
17adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency10.2SYP, INHA
18endometrial stromal sarcoma10.2DES, INHA
19glomus tumor10.2DES, SYP
20adrenocortical carcinoma10.2SYP, INHA
21adrenal cortical adenoma10.2INHA, SYP
22germinoma10.2INHA, AFP
23endodermal sinus tumor10.2INHA, AFP
24dysgerminoma10.2INHA, AFP
25frasier syndrome10.2
26carney complex, type 110.2
27alopecia10.2
28mast-cell sarcoma10.2
29neuroendocrine carcinoma10.2
30arteriovenous malformation10.2
31prostatic cyst10.2
32brucellosis10.2
33gastric adenocarcinoma10.2
34hermaphroditism10.2
35hypothyroidism10.2
36peritonitis10.2
37prostate adenocarcinoma10.2
38renal adenoma10.2
39sarcoma10.2
40struma ovarii10.2
41thyroiditis10.2
42vaginitis10.2
43complete androgen insensitivity syndrome10.2
44precocious puberty10.2
45testicular cancer10.1AFP, INHA
46pituitary adenoma10.1SYP, INHA
47rhabdomyosarcoma10.1INHA, DES
48wilms tumor10.1DES, INHA
49desmoplastic small round cell tumor10.1MUC1, DES
50mesenchymal chondrosarcoma10.1MUC1, DES

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to sertoli cell tumor

Symptoms for Sertoli Cell Tumor

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Drugs & Therapeutics for Sertoli Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Sertoli Cell Tumor

Search NIH Clinical Center for Sertoli Cell Tumor

Genetic Tests for Sertoli Cell Tumor

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Anatomical Context for Sertoli Cell Tumor

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MalaCards organs/tissues related to Sertoli Cell Tumor:

31
Testis, Ovary, Testes, Bone, Bone marrow, Lung, Prostate, Thyroid

Animal Models for Sertoli Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Sertoli Cell Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6MUC1, AFP, INHA

Publications for Sertoli Cell Tumor

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Articles related to Sertoli Cell Tumor:

(show top 50)    (show all 176)
idTitleAuthorsYear
1
Observations on the paper "sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases" by Kao et al. (25025367)
2014
2
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. (23412916)
2013
3
Malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome. (25191441)
2012
4
Sertoli cell tumor and gonadoblastoma in an untreated 29-year-old 46,XY phenotypic male with Frasier syndrome carrying a WT1 IVS9+4C>T mutation. (22908070)
2012
5
Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. (20004940)
2010
6
Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. (20587845)
2010
7
Acute abdomen due to rupture of Sertoli cell tumor. (19597832)
2010
8
Case report of malignant sertoli cell tumor]. (18697473)
2008
9
Sertoli cell tumor of the testis: a case with late metastasis. (18500567)
2008
10
Benign large cell calcifying Sertoli cell tumor of the testis in a prepubescent patient. (17646440)
2007
11
Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of alpha-methylacyl-CoA racemase (AMACR/P504S). (17252229)
2007
12
Interstitial cell tumor and Sertoli cell tumor in the testis of a cat. (17491086)
2007
13
Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis. (18176022)
2007
14
A 67-year-old woman with abdominal distention, vaginal bleeding, and elevated CA 125 level. Pure Sertoli cell tumor of the ovary with differentiation varying from well-differentiated tubules, to intermediate foci, to sarcomatoid spindle cell areas. (16683900)
2006
15
Large cell calcifying Sertoli cell tumor of the testis in a boy with brucellosis. (16970792)
2006
16
Carboplatin for treatment of a Sertoli cell tumor in a mallard (Anas platyrhynchos). (19754829)
2006
17
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)
2005
18
Sertoli cell tumor of the testis in children: reevaluation of a rarely encountered tumor. (16189443)
2005
19
Sclerosing Sertoli cell tumor of the testis. (16197877)
2005
20
Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. (15943795)
2005
21
Malignant seminoma with metastasis, Sertoli cell tumor, and pheochromocytoma in a spotted dolphin (Stenella frontalis) and malignant seminoma with metastasis in a bottlenose dolphin (Tursiops truncatus). (15872383)
2005
22
Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. (15644771)
2005
23
Pathologic quiz case: testicular pain and scrotal swelling in a 25-year-old man. Large cell calcifying Sertoli cell tumor of the testis. (15387684)
2004
24
Simultaneous sertoli cell tumor and adenocarcinoma of the tunica vaginalis testis in a patient with testicular feminization. (11855889)
2002
25
A case report of Sertoli cell tumor in a patient with testicular feminization: many dilemmas for the pathologist. (19753733)
2002
26
Utility of immunostaining for S-100 protein subunits in gonadal sex cord-stromal tumors, with emphasis on the large-cell calcifying Sertoli cell tumor of the testis. (11979368)
2002
27
Sertoli cell proliferations of the infantile testis: an intratubular form of Sertoli cell tumor? (11688457)
2001
28
Pathological case of the month. Sertoli cell tumor. (10768686)
2000
29
Sclerosing sertoli cell tumor of the testis--a case report and review of the literature. (10452297)
1999
30
Malignant large cell calcifying sertoli cell tumor with endocrine overactivity. (10210408)
1999
31
Malignant Sertoli cell tumor of the ovary metastatic to the lung mimicking neuroendocrine carcinoma: report of a case. (10459047)
1999
32
Metastatic testicular Sertoli-cell tumor: cytopathologic findings on fine-needle aspiration. (9702492)
1998
33
Sertoli cell tumor of the testis. Report of a case with imprint cytology findings. (9850662)
1998
34
Feminizing Sertoli cell tumors associated with Peutz-Jeghers syndrome: an increasingly recognized cause of prepubertal gynecomastia. (9734436)
1998
35
Sclerosing Sertoli cell tumor of the testis: a distinct histological subtype. (7563340)
1995
36
Carney's complex in a patient with hormone-producing Sertoli cell tumor of the testicle. (8411442)
1993
37
Fine needle aspiration cytology in malignant Sertoli cell tumor of the testis. A case report. (1636354)
1992
38
Large cell calcifying Sertoli cell tumor of the testis. A clinicopathologic, immunohistochemical, and ultrastructural study of two cases. (1746487)
1991
39
Fine needle aspiration cytology of a large cell calcifying Sertoli cell tumor of the testis. (3673461)
1987
40
Bone marrow hypoplasia in eight dogs with Sertoli cell tumor. (6113231)
1981
41
Malignant (androblastoma) Sertoli cell tumor of testes. (7281397)
1981
42
Gonadal stromal or sertoli cell tumor. (7052719)
1980
43
Peutz-Jeghers syndrome with feminizing sertoli cell tumor. (6770991)
1980
44
Sertoli cell tumor in two related newborn shorthorn calves. (7459797)
1980
45
Malignant androblastoma (Sertoli cell tumor) of the testis. A case report with a review of the literature. (167202)
1975
46
A sertoli-cell tumor in ectopic testicular tissue. (4747285)
1973
47
Malignant sertoli cell tumor of the testis. (5566364)
1971
48
Metastasizing Sertoli-cell tumor (androblastoma). (5812721)
1969
49
Androblastoma (Sertoli cell tumor): case report. (6057873)
1967
50
Sertoli cell tumor in an infant. (13346827)
1956

Variations for Sertoli Cell Tumor

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Expression for genes affiliated with Sertoli Cell Tumor

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Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for genes affiliated with Sertoli Cell Tumor

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Compounds for genes affiliated with Sertoli Cell Tumor

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Compounds related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1ganglioside439.7SYP, DES
2nad+439.7DES, INHA
3ccl443 2810.7DES, AFP
4azathioprine43 2 49 1212.5AFP, DES
5lithium43 49 24 1212.4SYP, MUC1
6progestin439.4MUC1, DES
7polyethylene glycol439.3MUC1, AFP
8galactose439.3MUC1, AFP
9hydrogen43 2410.2INHA, AFP, SYP
10fatty acid439.2AFP, INHA, DES
11silver439.2SYP, AFP, DES
12mifepristone43 28 59 1212.2MUC1, AFP
13agarose439.2MUC1, INHA
14h2o2439.1SYP, AFP, DES
15biotin43 24 1211.1DES, INHA, MUC1
16acth439.1INHA, MUC1, SYP
17s 100439.1SYP, MUC1, DES
18forskolin43 49 1211.0SYP, MUC1, INHA
19reticulin439.0SYP, MUC1, DES
20mucicarmine439.0DES, MUC1, SYP
21sialic acid439.0MUC1, AFP
22formaldehyde43 2410.0SYP, MUC1, DES
23adriamycin438.9MUC1, AFP, DES
24actinomycin d438.9MUC1, AFP, DES
25thymidine43 249.9DES, AFP, MUC1
26cisplatin43 49 59 1211.8SYP, MUC1, AFP
27dihydrotestosterone43 28 24 1211.8MUC1, DES
28cholesterol43 28 24 1211.8AFP, MUC1, SYP
29dexamethasone43 49 28 1211.8AFP, MUC1, SYP
30steroid438.7DES, INHA, AFP, SYP
31nitric oxide43 24 1210.7SYP, MUC1, DES
32hematoxylin438.6DES, INHA, MUC1, SYP
33threonine438.6DES, AFP, MUC1
34cyclic amp43 249.6DES, INHA, MUC1, SYP
35b 723438.4SYP, MUC1, AFP, DES
36gold438.4SYP, MUC1, AFP, DES
37ethanol43 49 24 1211.4SYP, MUC1, AFP, DES
38oxygen43 249.4DES, AFP, MUC1
39glycogen43 249.4DES, AFP, MUC1, SYP
40creatinine438.4DES, AFP, MUC1, SYP
41vegf438.4DES, AFP, MUC1, SYP
42retinoic acid43 249.4DES, AFP, MUC1, SYP
43serine438.3SYP, MUC1, AFP, DES
44calcium43 49 24 1211.3DES, AFP, MUC1, SYP
45estradiol43 24 1210.0DES, INHA, AFP, MUC1, SYP
46paraffin438.0DES, INHA, AFP, MUC1, SYP
47progesterone43 28 59 24 1212.0DES, INHA, AFP, MUC1, SYP
48testosterone43 59 24 1211.0DES, INHA, AFP, MUC1, SYP
49estrogen438.0DES, INHA, AFP, MUC1, SYP
50tyrosine437.9SYP, MUC1, AFP, INHA, DES

GO Terms for genes affiliated with Sertoli Cell Tumor

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Products for genes affiliated with Sertoli Cell Tumor

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Sources for Sertoli Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet