MCID: SRT002
MIFTS: 54

Sertoli Cell Tumor malady

Cancer diseases category

Summaries for Sertoli Cell Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a Sex cord-gonadal stromal tumor of a... more...

MalaCards: Sertoli Cell Tumor, also known as tubular androblastoma nos, is related to peutz-jeghers syndrome and seminoma. An important gene associated with Sertoli Cell Tumor is INHA (inhibin, alpha), and among its related pathways are Nuclear Receptor transcription pathway and Ovarian Infertility Genes. The compounds butyrate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and testes, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Aliases & Classifications for Sertoli Cell Tumor

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

sertoli cell tumor 8 10 44 60
tubular androblastoma nos 8


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Disease Ontology8 DOID:3577
NCIt39 C39976
MeSH34 D012707

Related Diseases for Sertoli Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome30.9INHA, CYP19A1, PRKAR1A
2seminoma30.6ALPP, ENO2, INHA, AFP, CGB, CGB5
3gynecomastia30.6PGR, INHA, CYP19A1, CGB5, AR
4androgen insensitivity syndrome30.5AR
5gonadoblastoma30.5ALPP, WT1
6cryptorchidism30.5ALPP, CYP19A1, NR5A1, CGB5, AR, WT1
7adenoma30.5ENO2, INHA, MUC1, NR5A1, SYP, PRKAR1A
8adenocarcinoma30.4ENO2, PGR, INHA, MUC1, NR5A1, SYP
9frasier syndrome30.1WT1
10neuroendocrine carcinoma30.1ENO2, MUC1, SYP
11cushing's syndrome30.1INHA, SYP, PRKAR1A
12leydig cell tumor30.1INHA, CYP19A1, NR5A1, CGB5, CALB2
13pheochromocytoma30.1ENO2, INHA, NR5A1, SYP, CALB2
14sarcoma30.1ENO2, MUC1, DES, MLANA, CGB, CGB5
15malignant sertoli cell tumor10.8
16carney complex10.3
17spermatic cord torsion10.3
18neuroendocrine tumor10.3
19prostatitis10.3
20mast-cell sarcoma10.1
21arteriovenous malformation10.1
22prostatic cyst10.1
23familial adenomatous polyposis10.1
24alopecia10.1
25brucellosis10.1
26gastric adenocarcinoma10.1
27hair disease10.1
28hermaphroditism10.1
29hypertension10.1
30hypothyroidism10.1
31peritonitis10.1
32prostate adenocarcinoma10.1
33renal adenoma10.1
34struma ovarii10.1
35testis seminoma10.1
36thyroiditis10.1
37vaginitis10.1
38image syndrome10.1
39ovarian malignant sertoli-leydig cell tumor10.1
40pancreatitis10.0ALPP
41cystadenoma10.0INHA
42thymoma10.0CALB2
43cystadenocarcinoma10.0MUC1
44syringoma10.0MUC1
45epithelioid trophoblastic tumor10.0INHA
46melanotic neuroectodermal tumor10.0SYP
47von hippel-lindau disease10.0INHA
48desmoid tumor10.0DES
49malignant peritoneal mesothelioma10.0CALB2
50cerebral primitive neuroectodermal tumor10.0ENO2

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to sertoli cell tumor

Clinical Features for Sertoli Cell Tumor

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Drugs & Therapeutics for Sertoli Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sertoli Cell Tumor

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Anatomical Context for Sertoli Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Sertoli Cell Tumor:

32
Testis, Ovary, Testes, Bone marrow, Bone, Prostate, Lung, Kidney, Skeletal muscle, Thyroid, Breast

Animal Models for Sertoli Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sertoli Cell Tumor:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2INHA, AFP, WT1
2MP:00053699.8SOX9, WT1, PRKAR1A, CYP19A1
3MP:00053899.8WT1, PRKAR1A, AFP, NR5A1, INHA
4MP:00053709.4INHA, CYP19A1, MUC1, AR, WT1, AMACR
5MP:00053769.2AMACR, SOX9, AR, PRKAR1A, DES, AFP
6MP:00020069.2AR, PRKAR1A, AFP, MUC1, INHA, PGR
7MP:00053808.9VIM, SOX9, WT1, AR, PRKAR1A, NR5A1
8MP:00053858.8VIM, SOX9, WT1, AR, PRKAR1A, DES
9MP:00053868.6VIM, CALB2, SOX9, AR, DES, AFP
10MP:00028738.4ALPP, CALB2, SOX9, WT1, AR, PRKAR1A
11MP:00053788.4VIM, AMACR, SOX9, WT1, AR, PRKAR1A
12MP:00107688.3VIM, AMACR, SOX9, WT1, AR, PRKAR1A

Publications for Sertoli Cell Tumor

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50PubMed
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Articles related to Sertoli Cell Tumor:

(show top 50)    (show all 300)
idTitleAuthorsYear
1
Sclerosing Sertoli cell tumor of the testis: a case report with review of the literature. (24228134)
2013
2
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. (24333107)
2013
3
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. (22635079)
2012
4
Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: case report and literature review. (22226390)
2012
5
Successful term pregnancies after laparoscopic excision of poorly differentiated Sertoli-Leydig cell tumor of the ovary. (22808364)
2012
6
Retiform Sertoli-Leydig cell tumor of ovary in a 9-year-old girl: case report and review of the literature. (21347632)
2011
7
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. (20930104)
2011
8
Pure Sertoli cell tumor. a case report and review of the literature. (20349797)
2010
9
Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. (19136796)
2009
10
Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. (19553598)
2009
11
Sertoli cell tumor of the testis: a case with late metastasis. (18500567)
2008
12
Immunohistochemical and ultrastructural analysis of a poorly differentiated pediatric age Sertoli-Leydig cell tumor. (17022971)
2007
13
Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis. (18176022)
2007
14
Synchronous sertoli cell and serous cystadenoma tumors of the ovaries with mixed epithelial and stromal tumor of the kidney: a case report. (17645832)
2007
15
Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. (17721194)
2007
16
Sclerosing Sertoli cell tumor of the testis. (21086416)
2007
17
Extracellular inosine participates in tumor necrosis factor-alpha induced nitric oxide production in cultured Sertoli cells. (16328964)
2006
18
Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. (17177833)
2006
19
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
20
Sclerosing Sertoli cell tumor of the testis. (16197877)
2005
21
Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. (15943795)
2005
22
Sertoli-Leydig cell tumor. (11205710)
2001
23
Malignant large cell calcifying sertoli cell tumor with endocrine overactivity. (10210408)
1999
24
Malignant large cell calcifying Sertoli cell tumor of the testis (LCCSCTT). Report of a case in an elderly man and review of the literature. (10484870)
1999
25
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
26
Malignant Sertoli cell tumor in a prepubescent boy. (9224377)
1997
27
Ovarian Sertoli-Leydig cell tumor: a SRY gene-independent pathway of pseudomale gonadal differentiation. (9343329)
1997
28
Ovarian Sertoli-Leydig cell tumor in an amenorrheic hirsute patient. (8828265)
1996
29
Sertoli-Leydig cell tumor of the ovary: a clinicopathologic study of 10 cases. (8750520)
1996
30
Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)
1995
31
Sclerosing Sertoli cell tumor of the testis: a distinct histological subtype. (7563340)
1995
32
Late presentation of an alpha-fetoprotein secreting isolated large upper abdominal retroperitoneal Sertoli-Leydig cell tumor recurrence. (7534742)
1995
33
Cytological, histological and ultrastructural findings of a pure benign Sertoli cell tumor. (7581529)
1995
34
In vitro production of cyclic AMP and steroids from an ovarian Sertoli-Leydig cell tumor. Notes on clinical management. (7732806)
1995
35
Isochromosome 1q as the sole karyotypic abnormality in a Sertoli cell tumor of the ovary. (8431922)
1993
36
Sertoli cell tumor in an HIV+ man. (8277167)
1993
37
Sclerosing Sertoli cell tumor of the testis. A report of 10 cases. (1719830)
1991
38
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
39
Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor. (2844882)
1988
40
Prostatic cyst and concurrent Sertoli cell tumor in a dog. (3372340)
1988
41
Mixed Sertoli-Leydig cell tumor and rete testis adenocarcinoma in rats treated with CdCl2. (2834860)
1988
42
Resistant hypertension associated with a renin-producing ovarian Sertoli cell tumor. (3511675)
1986
43
Steroid metabolism in an androblastoma (Sertoli-Leydig cell tumor): a histopathological and biochemical study. (6327547)
1984
44
Echographic findings in Sertoli cell tumor of the testis. (6788817)
1981
45
Large-cell calcifying Sertoli cell tumor of the testis. (7446466)
1980
46
Multiple neoplasia in a captive jungle cat (Felis chaus)--thyroid adenocarcinoma, gastric adenocarcinoma, renal adenoma, and Sertoli cell tumor. (4634529)
1972
47
Ultrastructure of an intermediate Sertoli-Leydig cell tumor. A histogenetic misnomer. (4311418)
1969
48
A CASE OF CANINE TESTICULAR SERTOLI CELL TUMOR. (14346563)
1965
49
Sertoli cell tumor in an infant. (13346827)
1956
50
Functional Sertoli cell tumor with metastasis in a dog. (13022505)
1952

Genetic Variations for Sertoli Cell Tumor

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Expression for genes affiliated with Sertoli Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sertoli Cell Tumor

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Pathways for genes affiliated with Sertoli Cell Tumor

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9PGR, NR5A1, AR
29.8PGR, INHA, CYP19A1, NR5A1

Compounds for genes affiliated with Sertoli Cell Tumor

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5CALB2
2estrogen4410.5NR5A1, CALB2
3reticulin4410.1VIM, DES, SYP, MUC1
4glutamate4410.0PRKAR1A, AR, AMACR
5s 1004410.0VIM, DES, SYP, MUC1, ENO2
6mucicarmine4410.0VIM, CALB2, DES, SYP, MUC1
7glycogen44 2411.0CGB5, AFP, SYP
8forskolin44 49 1112.0ENO2, PRKAR1A, WT1, VIM
9dihydrotestosterone44 28 11 2412.9VIM, CGB5, DES, CYP19A1, PGR
10clomiphene citrate449.9CGB5, CGB, AFP, CYP19A1, PGR
1117beta-hydroxysteroid449.8AR, CGB5, NR5A1, CYP19A1, PGR
12cycloheximide449.8SOX9, CGB5, NR5A1, ALPP
133beta-hydroxysteroid449.8AR, CGB5, NR5A1, CYP19A1, INHA, PGR
14etoposide44 49 59 1112.7VIM, WT1, AR, CGB5, CGB, AFP
15estrone44 28 11 2412.7AR, CGB5, AFP, NR5A1, CYP19A1, PGR
16creatinine449.7WT1, CGB5, CGB, AFP, SYP, ALPP
17formaldehyde44 2410.6VIM, DES, SYP, MUC1, CYP19A1, ENO2
18mifepristone44 59 28 1112.6AR, CGB5, CGB, AFP, MUC1, CYP19A1
19dexamethasone44 49 28 1112.6ALPP, ENO2, AFP, CGB5, AR, AMACR
20androstenedione44 2410.5AR, CGB5, CGB, CYP19A1, INHA
21hyaluronic acid44 2410.5VIM, CALB2, WT1, DES, MUC1, ENO2
22diethylstilbestrol44 28 1111.5AR, CGB5, AFP, NR5A1, CYP19A1, PGR
23b 723449.4ALPP, MUC1, SYP, AFP, DES, WT1
24folate449.4VIM, CGB5, AFP, MUC1, PGR, ALPP
25gnrh449.4VIM, AR, CGB5, CGB, NR5A1, CYP19A1
26tamoxifen44 49 28 1112.4VIM, AR, CGB5, MUC1, CYP19A1, PGR
27progestin449.4VIM, AR, CGB5, DES, MUC1, CYP19A1
28dmso449.4VIM, CGB5, AFP, MUC1, PGR, ENO2
29cysteine449.4VIM, AMACR, CGB, PRKAR1A, DES, SYP
30doxorubicin44 49 1111.4VIM, WT1, AR, CGB5, DES, AFP
31methotrexate44 49 1111.3VIM, CGB5, CGB, AFP, MUC1, CYP19A1
32serine449.3SOX9, WT1, DES, AFP, SYP, NR5A1
33glutamine449.3VIM, SOX9, WT1, AR, AFP, SYP
34actinomycin d449.2VIM, AR, CGB5, DES, AFP, NR5A1
35ribonucleic acid449.2SOX9, WT1, CGB5, NR5A1, MUC1, INHA
36acth449.2CGB5, SYP, NR5A1, MUC1, INHA, ENO2
37silver449.2DES, AFP, SYP, ENO2, CALB2
38vitamin d449.1VIM, AMACR, WT1, AR, PRKAR1A, AFP
39hematoxylin449.1DES, MLANA, CALB2, AMACR, VIM, SYP
40thymidine44 2410.1CALB2, WT1, DES, AFP, NR5A1, MUC1
41cyclic amp44 2410.1VIM, SOX9, CGB5, CGB, PRKAR1A, DES
42lactate449.1VIM, CGB5, CGB, MLANA, DES, AFP
43adenylate449.0VIM, AMACR, AR, CGB5, PRKAR1A, DES
44estradiol44 11 2410.9PGR, INHA, CYP19A1, MUC1, NR5A1, SYP
45vegf448.4CGB5, AR, WT1, SOX9, VIM, CGB
46steroid448.3PRKAR1A, MLANA, CGB5, AR, WT1, SOX9
47retinoic acid44 249.0CGB5, AR, WT1, SOX9, AMACR, VIM
48paraffin447.9AFP, DES, MLANA, CGB5, AR, WT1
49progesterone44 59 28 11 2411.9ENO2, PGR, INHA, CYP19A1, MUC1, NR5A1
50testosterone44 59 11 2410.4ALPP, CALB2, AMACR, VIM, SOX9, WT1

GO Terms for genes affiliated with Sertoli Cell Tumor

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16Gene Ontology
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Cellular components related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.7SYP, PRKAR1A, AR, SOX9

Biological processes related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1tertiary branching involved in mammary gland duct morphogenesisGO:06074810.2AR, PGR
2negative regulation of female gonad developmentGO:200019510.2WT1, NR5A1
3prostate gland developmentGO:03085010.1AR, SOX9
4positive regulation of male gonad developmentGO:200002010.0SOX9, WT1, NR5A1
5prostate gland growthGO:06073610.0CYP19A1, AR
6ovulation from ovarian follicleGO:0015429.9AFP, PGR
7cell-cell signalingGO:0072679.8PGR, INHA, NR5A1, CGB, AR
8male gonad developmentGO:0085849.8INHA, NR5A1, AR, WT1, SOX9
9signal transductionGO:0071659.4PGR, INHA, PRKAR1A, CGB, AR, SOX9

Molecular functions related to Sertoli Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.8PGR, NR5A1, AR
2receptor bindingGO:0051029.8PGR, INHA, AR, AMACR
3protein kinase A catalytic subunit bindingGO:0342369.7PRKAR1A, SOX9

Products for genes affiliated with Sertoli Cell Tumor

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Sources for Sertoli Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet