Sertoli Cell Tumor malady

Wikipedia: A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a Sex cord-gonadal stromal tumor of a...⁴⁴ more...

MalaCards: Sertoli Cell Tumor, also known as tubular androblastoma nos (morphologic abnormality), is related to malignant sertoli cell tumor and peutz-jeghers syndrome. An important gene associated with Sertoli Cell Tumor is ALPP (alkaline phosphatase, placental), and among its related pathways are African trypanosomiasis and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds dmso and s 100 have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and testis leydig, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

sertoli cell tumor 6 8 32 43 tubular androblastoma nos (morphologic abnormality) 6

Diseases related to sertoli cell tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 620)

id	Related Disease	Score	Top Affiliating Genes
1	malignant sertoli cell tumor	33.7	CGB5, ALPP, AFP
2	peutz-jeghers syndrome	31.1	INHA, CYP19A1, STK11, PRKAR1A
3	androgen insensitivity syndrome	30.5	AR, CYP19A1
4	complete androgen insensitivity syndrome	30.3	AR, CYP19A1
5	benign tumors	30.2	PCNA, VIM, MUC1, DES, STK11, PGR
6	gynecomastia	28.8	MUC1, CGB, CGB5, AR, INHA, CYP19A1
7	carcinoid tumors	27.1	PCNA, MUC1, CGB, MLANA, INHA, ENO2
8	seminoma	26.3	KIT, SELE, VIM, VCAM1, CGB, CGB5
9	leydig cell tumor	25.9	KIT, VIM, MUC1, CGB, CGB5, INHA
10	21-hydroxylase deficiency	13.7	INHA, SYP
11	malignant germ cell tumor	13.7	CGB5, AFP
12	spindle cell thymoma	13.7	MUC1, DES
13	lymph node palisaded myofibroblastoma	13.7	VIM, DES
14	myxosarcoma	13.7	VIM, DES
15	infantile digital fibromatosis	13.7	VIM, DES
16	heart cancer	13.7	VIM, CALB2
17	prostate leiomyoma	13.7	VIM, DES
18	clear cell ependymoma	13.7	VIM, MUC1
19	estrogen excess	13.7	CYP19A1, PGR
20	prostate stromal sarcoma	13.7	VIM, MUC1
21	epithelioid trophoblastic tumor	13.7	CGB5, INHA, ALPP
22	myoma	13.7	DES, PGR
23	epithelioid leiomyosarcoma	13.7	VIM, DES
24	glomangiomyoma	13.7	VIM, DES
25	infantile myofibromatosis	13.6	VIM, DES
26	meninges sarcoma	13.6	VIM, DES
27	central nervous system germinoma	13.6	CGB, ALPP
28	radiation induced meningioma	13.6	VIM, PGR
29	ovarian small cell carcinoma	13.6	INHA, CALB2, DES
30	aromatase excess syndrome	13.6	CGB5, CYP19A1
31	adenoid squamous cell carcinoma	13.6	VIM, MUC1
32	endometrial mucinous adenocarcinoma	13.6	VIM, MUC1
33	clear cell meningioma	13.6	VIM, MUC1
34	habitual abortion	13.6	CGB, CGB5
35	sex cord-gonadal stromal tumor	13.6	VIM, INHA, CALB2
36	gastric leiomyosarcoma	13.6	DES, PGR
37	pleomorphic liposarcoma	13.6	VIM, INHA, CALB2
38	liver sarcoma	13.6	VIM, AFP
39	fibrous meningioma	13.6	MUC1, DES
40	gestational trophoblastic neoplasm	13.6	CGB5, INHA, AFP
41	myofibroma	13.6	VIM, DES
42	adenofibroma	13.6	INHA, CALB2, PGR
43	nodular hidradenoma	13.6	VIM, MUC1
44	osteoblastoma	13.6	VIM, MUC1
45	placental site trophoblastic tumor	13.6	CGB, CGB5, ALPP
46	gastric small cell carcinoma	13.6	ENO2, SYP
47	central nervous system germ cell tumor	13.6	CGB, AFP
48	mature teratoma	13.6	CGB, ALPP, AFP
49	testicular microlithiasis	13.6	CGB, AFP
50	congenital epulis	13.6	VIM, ENO2, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to sertoli cell tumor:

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MGI Mouse Phenotypes related to sertoli cell tumor:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.0	PRKAR1A, SOX9
2	endocrine/exocrine gland phenotype	MP:0005379	9.4	INHA, AFP, SOX9, PRKAR1A, WT1, NR5A1
3	liver/biliary system phenotype	MP:0005370	9.4	CYP19A1, AMACR, AR, KIT
4	no phenotypic analysis	MP:0003012	8.8	SOX9, STK11, SYP, MUC1, VCAM1, PCNA
5	hematopoietic system phenotype	MP:0005397	8.7	SOX9, PRKAR1A, STK11, INHA, PCNA, KIT
6	integument phenotype	MP:0010771	8.6	PGR, SOX9, STK11, CYP19A1, MUC1, KIT
7	immune system phenotype	MP:0005387	8.5	SOX9, PRKAR1A, STK11, WT1, CYP19A1, INHA
8	embryogenesis phenotype	MP:0005380	8.5	PGR, SOX9, PRKAR1A, STK11, NR5A1, ALPP
9	reproductive system phenotype	MP:0005389	8.4	AFP, SOX9, PRKAR1A, STK11, TGFB1, WT1
10	nervous system phenotype	MP:0003631	7.7	SOX9, STK11, SYP, TGFB1, NR5A1, CYP19A1
11	tumorigenesis	MP:0002006	7.1	AFP, PGR, PRKAR1A, STK11, TGFBR2, TGFB1
12	digestive/alimentary phenotype	MP:0005381	7.1	SOX9, PRKAR1A, STK11, TGFBR2, TGFB1, ICAM1
13	normal phenotype	MP:0002873	7.1	TGFBR2, SYP, STK11, PRKAR1A, PGR, WT1
14	mortality/aging	MP:0010768	7.0	DES, STK11, PRKAR1A, SOX9, AFP, TGFBR2
15	behavior/neurological phenotype	MP:0005386	6.8	TGFBR2, DES, STK11, SOX9, PGR, NR5A1
16	muscle phenotype	MP:0005369	6.5	DES, STK11, PRKAR1A, SOX9, PGR, TGFBR2
17	vision/eye phenotype	MP:0005391	6.4	TGFBR2, STK11, PRKAR1A, SOX9, TGFB1, ICAM1
18	cardiovascular system phenotype	MP:0005385	5.0	TGFB1, TGFBR2, DES, STK11, PRKAR1A, SOX9
19	growth/size phenotype	MP:0005378	5.0	NR5A1, WT1, TGFB1, TGFBR2, STK11, PRKAR1A
20	cellular phenotype	MP:0005384	4.6	WT1, TGFB1, TGFBR2, STK11, PRKAR1A, SOX9
21	homeostasis/metabolism phenotype	MP:0005376	4.4	WT1, TGFB1, TGFBR2, DES, STK11, PRKAR1A

Articles related to sertoli cell tumor:

(show all 25)

id	Title	Authors	Year	Affiliating Genes
1	Large cell calcifying Sertoli cell tumor: a clinicopa thologic study of 1 malignant and 3 benign tumors using histomorphology, immuno histochemistry, ultrastructure, comparative genomic hybridization, and polymera se chain reaction analysis of the PRKAR1A gene. (20004940)	Petersson F.... Hes O.	2010	PRKAR1A
2	A case of sertoli cell tumor with arteriovenous malf ormation (20104012)	Sasaki M.... Ota S.	2010	CGB
3	Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. (19255517)	Yu C.H.... Sur J.H.	2009	KIT, VIM, DES
4	Case report of malignant sertoli cell tumor (18697473)	Sassa N.... Gotoh M.	2008	AFP, CGB5
5	SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor. (18753972)	Zhao C.... Vang R.	2008	NR5A1, WT1
6	Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of alpha-methylacyl-CoA racemase (AMACR/P504S). (17252229)	Sato K.... Katsuda S.	2007	AMACR
7	Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. (17721194)	Zhao C.... Vang R.	2007	WT1, CALB2
8	Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian sertoli cell tumor from endometrioid tumors and carcinoid tumor: A study of 160 cases. (17255771)	Zhao C.... Vang R.	2007	MUC1, SYP, KRT7
9	Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis. (17197889)	Zhao C.... Vang R.	2007	SOX9
10	High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis. (16944977)	Saraco N.... Rivarola M.A.	2006	TGFBR2, TGFB1, CYP19A1
11	Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)	Kara C.... Senel F.	2005	CYP19A1
12	Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. (15943795)	Sato K.... Katsuda S.	2005	INHA, CALB2
13	Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. (15644771)	Oliva E.... Young R.H.	2005	MUC1, CALB2
14	A case of Sertoli cell tumor (16440732)	Miwa S.... Taya T.	2005	AFP, CGB
15	Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-alpha. (15363041)	Kuroda N.... Enzan H.	2004	INHA
16	Metastatic ovarian Sertoli-cell tumor: FNA findings with immunohistochemistry. (14595797)	Watson B.... Ylagan L.R.	2003	INHA
17	Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. (11979085)	Henley J.D.... Ulbright T.M.	2002	ALPP
18	Sertoli cell proliferations of the infantile testis: an intratubular form of Sertoli cell tumor? (11688457)	Venara M.... Chemes H.	2001	INHA
19	Large cell calcifying Sertoli cell tumor of the testis: a clinicopathological, immunohistochemical, and ultrastructural study of two cases. (10503745)	Cano-Valdez A.M.... DomA-nguez-MalagA^n H.	1999	VIM
20	Sertoli cell tumor of the testis: a case report (10466070)	Yuasa J.... Matsuzaki S.	1999	CGB
21	Testicular Sertoli cell tumor with a heterologous sarcomatous component: immunohistochemical assessment of Sertoli cell differentiation. (9786352)	Gilcrease M.Z.... Albores-Saavedra J.	1998	VIM, MUC1
22	Large cell calcifying Sertoli cell tumor of the testis: contrasting features of six malignant and six benign tumors and a review of the literature. (9351565)	Kratzer S.S.... Young R.H.	1997	PCNA
23	Sertoli Cell Tumor of Testes in a Child with Peutz-Jeghers syndrome. (18417782)	Hasan M.A.... Khanan M.	1997	CYP19A1
24	A(870)E mutation of the androgen receptor gene in a patient with complete androgen insensitivity syndrome and Sertoli cell tumor. (9332480)	Knoke I.... Wieacker P.	1997	AR
25	Sertoli cells, but not tumor cells, of seminoma in situ express ICAM-1. (8982245)	Braendstrup O.... Werdelin O.	1996	ICAM1, SELE, VCAM1

Genes related to sertoli cell tumor according to GeneCards:

(show all 29)

id	Symbol	Description	Score	GeneCards Section Context
1	ALPP	alkaline phosphatase, placental	11.0	Publications
2	INHA	inhibin, alpha	11.0	Publications
3	CALB2	calbindin 2	11.0	Publications
4	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
5	SYP	synaptophysin	11.0	Publications
6	MUC1	mucin 1, cell surface associated	11.0	Publications
7	VIM	vimentin	11.0	Publications
8	ENO2	enolase 2 (gamma, neuronal)	11.0
9	DES	desmin	11.0	Publications
10	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
11	AFP	alpha-fetoprotein	11.0	Publications
12	PGR	progesterone receptor	11.0
13	AR	androgen receptor	11.0	Publications
14	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
15	SOX9	SRY (sex determining region Y)-box 9	11.0	Publications
16	AMACR	alpha-methylacyl-CoA racemase	11.0	Publications
17	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	11.0	Publications
18	KRT7	keratin 7	11.0	Publications
19	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0	Publications
20	MLANA	melan-A	11.0
21	WT1	Wilms tumor 1	11.0	Publications
22	STK11	serine/threonine kinase 11	11.0
23	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
24	PCNA	proliferating cell nuclear antigen	11.0	Publications
25	ICAM1	intercellular adhesion molecule 1	11.0	Publications
26	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
27	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
28	SELE	selectin E	11.0	Publications
29	TGFB1	transforming growth factor, beta 1	11.0	Publications

Pathways related to sertoli cell tumor according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	African trypanosomiasis20	8.8	SELE, VCAM1, ICAM1
2	IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.8	TGFBR2, TGFB1, VCAM1
3	Malaria20	8.2	SELE, VCAM1, ICAM1, TGFB1

Compounds related to sertoli cell tumor according to GeneDecks:

(show top 50)    (show all 202)

id	Compound	Score	Top Affiliating Genes
1	dmso32	9.9	ALPP, PGR, CGB5, AFP, VIM
2	s 10032	9.9	SYP, MUC1, DES, ENO2, VIM
3	hyaluronic acid32 18	10.9	VIM, MUC1, CALB2, WT1, DES
4	progestin32	9.8	CGB5, ALPP, CYP19A1, DES, AR, VIM
5	aspartate32	9.8	VIM, PCNA, PGR, CYP19A1
6	mucicarmine32	9.8	CALB2, DES, SYP, KRT7, MUC1, VIM
7	reticulin32	9.5	SYP, PCNA, VIM, MUC1, KRT7, DES
8	diethylstilbestrol32 9 9	11.4	CGB5, AR, ENO2, CYP19A1, NR5A1, PGR
9	mifepristone32 42 9 9	12.2	MUC1, CGB, AR, CYP19A1, PGR, AFP
10	gnrh32	9.1	AR, INHA, TGFBR2, CGB5, CGB, VIM
11	cysteine32	8.8	PRKAR1A, ALPP, CGB, TGFBR2, AMACR, MUC1
12	b 72332	8.8	MUC1, VIM, PCNA, ALPP, CALB2, WT1
13	cyclic amp32 18	9.7	NR5A1, INHA, CGB5, SYP, CGB, STK11
14	dihydrotestosterone32 9 18 9	11.5	PGR, DES, MUC1, TGFBR2, VIM, TGFB1
15	folate32	8.4	VCAM1, MUC1, CGB5, ALPP, PGR, AFP
16	butyrate32	8.4	VIM, AFP, TGFB1, WT1, CYP19A1, CALB2
17	pge232	8.3	VCAM1, CGB5, AR, CYP19A1, SELE, NR5A1
18	glycogen32 18	9.3	AFP, DES, VIM, STK11, CGB5, MUC1
19	glucose32	8.3	STK11, PRKAR1A, DES, CGB, KRT7, KIT
20	estradiol32 9 18 9	11.2	PCNA, VIM, MUC1, CGB, AR, CYP19A1
21	etoposide32 42 9 9	11.2	ENO2, AR, AFP, CGB5, CGB, SELE
22	5-aza-2deoxycytidine32	8.1	TGFBR2, PCNA, VIM, AR, NR5A1, KRT7
23	polyethylene glycol32	8.0	ICAM1, ALPP, PCNA, TGFB1, MUC1, AFP
24	hematoxylin32	7.9	KIT, VIM, MUC1, MLANA, INHA, ENO2
25	vitamin d32	7.8	PRKAR1A, AFP, TGFBR2, TGFB1, WT1, NR5A1
26	polysaccharide32	7.7	SELE, TGFB1, AFP, ICAM1, AR, CGB5
27	thymidine32 18	8.6	KIT, MUC1, ENO2, ALPP, CALB2, PCNA
28	ribonucleic acid32	7.5	INHA, KIT, CGB5, ENO2, NR5A1, WT1
29	genistein32 9 18 9	10.5	CYP19A1, PCNA, SELE, VIM, VCAM1, AR
30	matrigel32	7.5	VCAM1, VIM, SELE, ICAM1, AR, TGFB1
31	estrogen32	7.5	AFP, PCNA, CGB, CGB5, PGR, DES
32	steroid32	7.3	PRKAR1A, AFP, PGR, KIT, CGB5, SOX9
33	doxorubicin32 34 9 9	10.3	CGB5, PGR, DES, VIM, SELE, TGFB1
34	creatinine32	7.3	SYP, TGFB1, AFP, DES, CGB, MUC1
35	formaldehyde32 18	8.2	PCNA, KIT, SELE, VIM, MUC1, ENO2
36	glutamine32	7.1	ENO2, AR, PCNA, KIT, WT1, TGFB1
37	tamoxifen32 34 9 9	10.0	VCAM1, MUC1, CGB5, AR, ALPP, CYP19A1
38	adenylate32	6.9	AMACR, TGFBR2, STK11, PGR, SELE, PRKAR1A
39	progesterone32 42 9 18 9	10.9	INHA, AR, CGB5, CGB, PCNA, KIT
40	methotrexate32 34 42 9 9	10.8	KIT, PCNA, SELE, VIM, MUC1, CGB
41	retinoic acid32 42 18	8.7	CGB5, KIT, AR, ENO2, AMACR, PGR
42	actinomycin d32	6.6	NR5A1, AFP, KIT, SELE, VIM, MUC1
43	alanine32	6.5	CGB, INHA, ENO2, ALPP, TGFB1, TGFBR2
44	cycloheximide32	6.4	KIT, VIM, CGB5, AR, ICAM1, ALPP
45	lactate32	6.2	KIT, PCNA, SELE, VIM, VCAM1, CGB
46	dexamethasone32 42 34 9 9	10.2	PRKAR1A, SOX9, PGR, AFP, SYP, TGFBR2
47	paraffin32	5.5	TGFB1, KRT7, WT1, CALB2, ALPP, AMACR
48	serine32	5.4	DES, VIM, VCAM1, MUC1, CGB5, AR
49	testosterone32 9 18 9	7.9	SYP, NR5A1, CYP19A1, CALB2, ALPP, AMACR
50	vegf32	4.1	WT1, ALPP, ICAM1, ENO2, AR, CGB5

Cellular components related to sertoli cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein complex	GO:043234	9.3	AR, SYP, STK11, PRKAR1A, SOX9

Biological processes related to sertoli cell tumor according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of female gonad development	GO:2000195	10.0	NR5A1, WT1
2	adrenal gland development	GO:030325	9.9	CYP19A1, NR5A1, WT1
3	positive regulation of male gonad development	GO:2000020	9.9	SOX9, WT1, NR5A1
4	cellular response to glucose stimulus	GO:071333	9.7	CYP19A1, ICAM1, VCAM1
5	negative regulation of epithelial cell proliferation	GO:050680	9.6	AR, TGFB1, SOX9
6	tissue development	GO:009888	9.6	WT1, NR5A1
7	cell-cell signaling	GO:007267	9.6	PGR, NR5A1, INHA, AR, CGB
8	membrane to membrane docking	GO:022614	9.5	ICAM1, VCAM1
9	response to ionizing radiation	GO:010212	9.4	VCAM1, ICAM1, CYP19A1, STK11
10	ovarian follicle development	GO:001541	9.3	KIT, INHA, ICAM1
11	regulation of cell proliferation	GO:042127	9.2	SOX9, TGFBR2, INHA, KIT
12	leukocyte cell-cell adhesion	GO:007159	9.0	SELE, VCAM1, ICAM1
13	heterophilic cell-cell adhesion	GO:007157	9.0	ICAM1, VCAM1, SELE
14	heart development	GO:007507	8.9	TGFBR2, WT1, VCAM1, PCNA
15	male gonad development	GO:008584	8.8	KIT, AR, INHA, CYP19A1, NR5A1, WT1
16	response to drug	GO:042493	8.6	ENO2, ICAM1, CYP19A1, TGFB1, TGFBR2

Molecular functions related to sertoli cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	4.1	KIT, SOX9, PRKAR1A, STK11, DES, TGFBR2