MCID: SRT002
MIFTS: 32

Sertoli Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Sertoli Cell Tumor

MalaCards integrated aliases for Sertoli Cell Tumor:

Name: Sertoli Cell Tumor 12 51 41 14 69
Tubular Androblastoma Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3577
MeSH 41 D012707
NCIt 46 C39976
UMLS 69 C0036769

Summaries for Sertoli Cell Tumor

MalaCards based summary : Sertoli Cell Tumor, also known as tubular androblastoma nos, is related to frasier syndrome and malignant sertoli cell tumor. An important gene associated with Sertoli Cell Tumor is SYP (Synaptophysin), and among its related pathways/superpathways is Ovarian Infertility Genes. Affiliated tissues include testis, ovary and testes, and related phenotype is normal.

Related Diseases for Sertoli Cell Tumor

Diseases in the Sertoli Cell Tumor family:

Malignant Sertoli Cell Tumor

Diseases related to Sertoli Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 frasier syndrome 29.7 NR5A1 WT1
2 malignant sertoli cell tumor 12.3
3 carney complex, type 1 11.0
4 gynandroblastoma 10.4 CALB2 VIM
5 fallopian tube carcinosarcoma 10.4 CALB2 WT1
6 granular cell tumor 10.4 INHA VIM
7 peutz-jeghers syndrome 10.3
8 spindle cell liposarcoma 10.3 CALB2 WT1
9 malignant biphasic mesothelioma 10.3 CALB2 WT1
10 pneumatosis cystoides intestinalis 10.3 CALB2 WT1
11 metanephric adenoma 10.3 VIM WT1
12 pleural cancer 10.3 CALB2 WT1
13 primary hepatic neuroendocrine carcinoma 10.3 SYP VIM
14 dysgerminoma of ovary 10.3 CALB2 WT1
15 rhabdoid meningioma 10.3 SYP VIM
16 large cell medulloblastoma 10.3 SYP VIM
17 astroblastoma 10.3 SYP VIM
18 melanotic neuroectodermal tumor 10.3 SYP VIM
19 angiocentric glioma 10.3 SYP VIM
20 medulloepithelioma 10.3 SYP VIM
21 functional colonic disease 10.3 CALB2 SYP
22 microcystic adenoma 10.2 INHA MUC1
23 horseshoe kidney 10.2 CALB2 SYP
24 peritoneal serous adenocarcinoma 10.2 SYP WT1
25 46,xy partial gonadal dysgenesis 10.2 NR5A1 WT1
26 fibrolamellar carcinoma 10.2 SYP VIM
27 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.2 INHA SYP
28 ovarian brenner tumor 10.2 CALB2 WT1
29 glomus tumor 10.2 SYP VIM
30 cauda equina neoplasm 10.2 SYP WT1
31 mucinous bronchioloalveolar adenocarcinoma 10.2 CALB2 MUC1
32 bile duct cystadenocarcinoma 10.2 CALB2 MUC1
33 colonic pseudo-obstruction 10.2 CALB2 SYP
34 infant gynecomastia 10.2
35 gynecomastia 10.2
36 malignant peritoneal mesothelioma 10.2 MUC1 VIM
37 parachordoma 10.2 MUC1 VIM
38 sertoli-leydig cell tumor 10.2 CALB2 MUC1
39 ossifying fibromyxoid tumor 10.2 MUC1 VIM
40 biphasic synovial sarcoma 10.2 MUC1 VIM
41 fibrous meningioma 10.2 MUC1 VIM
42 malignant mixed mullerian tumor 10.2 MUC1 VIM
43 nodular hidradenoma 10.2 MUC1 VIM
44 ovarian serous carcinoma 10.2 CALB2 WT1
45 clear cell meningioma 10.2 MUC1 VIM
46 syringocystadenoma papilliferum 10.2 MUC1 VIM
47 eccrine porocarcinoma 10.2 MUC1 VIM
48 endometrial mucinous adenocarcinoma 10.2 MUC1 VIM
49 ovarian mucinous neoplasm 10.2 SYP WT1
50 myxopapillary ependymoma 10.2 MUC1 VIM

Graphical network of the top 20 diseases related to Sertoli Cell Tumor:



Diseases related to Sertoli Cell Tumor

Symptoms & Phenotypes for Sertoli Cell Tumor

MGI Mouse Phenotypes related to Sertoli Cell Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 CALB2 INHA NR5A1 PRKAR1A SYP WT1

Drugs & Therapeutics for Sertoli Cell Tumor

Search Clinical Trials , NIH Clinical Center for Sertoli Cell Tumor

Cochrane evidence based reviews: sertoli cell tumor

Genetic Tests for Sertoli Cell Tumor

Anatomical Context for Sertoli Cell Tumor

MalaCards organs/tissues related to Sertoli Cell Tumor:

38
Testis, Ovary, Testes, Bone, Prostate, Bone Marrow, Lung

Publications for Sertoli Cell Tumor

Articles related to Sertoli Cell Tumor:

(show top 50) (show all 193)
# Title Authors Year
1
Bilateral Sertoli Cell Tumors in a Patient with Androgen Insensitivity Syndrome. ( 28386495 )
2017
2
An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report. ( 28276158 )
2017
3
Mayer-Rokitansky-KA1ster-Hauser Syndrome With Bilateral Ovarian Sertoli Cell Tumors: Review of the Literature and Report of a Rare Case. ( 28922305 )
2017
4
A CASE OF AN AROMATASE-PRODUCING SERTOLI CELL TUMOR PRESENTING WITH GYNECOMASTIA. ( 28442671 )
2016
5
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report. ( 27488929 )
2016
6
Management of an invasive and metastatic Sertoli cell tumor with associated myelotoxicosis in a dog. ( 26933269 )
2016
7
Unusual Sertoli Cell Tumor Associated With Sex Cord Tumor With Annular Tubules in Peutz-Jeghers Syndrome: Report of a Case and Review of the Literature on Ovarian Tumors in Peutz-Jeghers Syndrome. ( 26621753 )
2016
8
RESPONSE TO THE ANASTROZOLE TREATMENT IN A CASE WITH PEUTZ-JEGHERS SYNDROME WHO WAS DETECTED TO HAVE LARGE CELL CALCIFYING SERTOLI CELL TUMOR AND DEVELOPED PRE-PUBERTAL GYNECOMASTIA. ( 27873740 )
2016
9
A spontaneously occurring malignant ovarian Sertoli cell tumor in a young Sprague Dawley rat. ( 26989303 )
2016
10
Sertoli cell tumor arising in a cryptorchid testis presenting as a content of inguinal hernial sac. ( 27510681 )
2016
11
LARGE CELL CALCIFYING SERTOLI CELL TUMOR OF THE TESTIS: A CASE REPORT. ( 28740051 )
2016
12
Nuclear Localization of I^-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases. ( 26034868 )
2015
13
Partial Orchiectomy for the Treatment of a Benign Sclerosing Sertoli Cell Tumor: A Report of a Rare Tumor in Association With Testicular Microlithiasis. ( 26793488 )
2015
14
A Rare Cause of Prepubertal Gynecomastia: Sertoli Cell Tumor. ( 26366315 )
2015
15
What is your diagnosis? Cryptorchidism and Sertoli cell tumor. ( 25970213 )
2015
16
Isolated Large Cell Calcifying Sertoli Cell Tumor in a Young Boy, not Associated with Peutz-Jeghers Syndrome or Carney Complex. ( 26587565 )
2015
17
Sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases. ( 24552667 )
2014
18
Melanotic Sertoli cell tumor. ( 25007144 )
2014
19
Testicular sclerosing sertoli cell tumor: a case report and review of the literature. ( 25548547 )
2014
20
Large cell calcifying sertoli cell tumor of the testis: a case study and review of the literature. ( 24627695 )
2014
21
Frequent mutation and nuclear localization of I^-catenin in sertoli cell tumors of the testis. ( 24061522 )
2014
22
Observations on the paper "sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases" by Kao et al. ( 25025367 )
2014
23
Intratubular Large Cell Hyalinizing Sertoli Cell Tumor of the Testes in a 4-Year-Old Male With Peutz-Jeghers Syndrome. ( 25171448 )
2014
24
Use of Aromatase Inhibitors in Large Cell Calcifying Sertoli Cell Tumors: Effects on Gynecomastia, Growth Velocity, and Bone Age. ( 25226294 )
2014
25
Sclerosing Sertoli cell tumor of the testis: a case report with review of the literature. ( 24228134 )
2013
26
Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review. ( 23412916 )
2013
27
Magnetic resonance imaging findings of sclerosing Sertoli cell tumor of the testis. ( 23329316 )
2013
28
Sertoli cell tumor and gonadoblastoma in an untreated 29-year-old 46,XY phenotypic male with Frasier syndrome carrying a WT1 IVS9+4C>T mutation. ( 22908070 )
2012
29
Bilateral Sertoli cell tumors of the testis-a likely new extracolonic manifestation of familial adenomatous polyposis. ( 23090627 )
2012
30
Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: case report and literature review. ( 22226390 )
2012
31
Sertoli cell tumors associated with feminizing syndrome and spermatic cord torsion in two cryptorchid dogs. ( 22705745 )
2012
32
What is your diagnosis? Sertoli cell tumor with multiorgan metastasis. ( 23409440 )
2012
33
Testicular sclerosing Sertoli cell tumor: an additional case and review of the literature. ( 23155292 )
2012
34
Malignant sertoli cell tumor in a goose (Anser cygnoides domesticus). ( 23397858 )
2012
35
Malignant large cell calcifying sertoli cell tumor of testis with skip metastasis to lung presented with peutz-jeghers syndrome. ( 25191441 )
2012
36
Sertoli cell tumor and intratubular germ cell neoplasia located in separate gonads in an adolescent patient with complete androgen insensitivity: a case report and review of literature. ( 22876554 )
2012
37
Organ-sparing surgery of the bilateral testicular large cell calcifying sertoli cell tumor in patient with atypical Peutz-Jeghers syndrome. ( 22160729 )
2012
38
Pathology in practice: Sertoli cell tumor (SCT). ( 22720987 )
2012
39
Spermatocytic seminoma with neuroectodermal differentiation and sertoli cell tumor in a dog. ( 20930104 )
2011
40
An unusual cause of infantile gynecomastia: sertoli cell tumor. ( 21358339 )
2011
41
Spontaneous sertoli cell tumor with cryptorchism in a beagle dog. ( 21826179 )
2011
42
Sertoli cell tumor, a rare testicular tumor, our experience and review of the literature. ( 20587845 )
2010
43
[A case of sertoli cell tumor with arteriovenous malformation]. ( 20104012 )
2010
44
Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. ( 20004940 )
2010
45
Pure Sertoli cell tumor. a case report and review of the literature. ( 20349797 )
2010
46
Acute abdomen due to rupture of Sertoli cell tumor. ( 19597832 )
2010
47
Sertoli cell tumor with benign peritoneal implants associated with gonadoblastoma. ( 20736766 )
2010
48
Malignant sertoli cell tumor of the testis with a large retroperitoneal mass in an elderly man. ( 21170861 )
2010
49
Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. ( 19553598 )
2009
50
Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. ( 19255517 )
2009

Variations for Sertoli Cell Tumor

Expression for Sertoli Cell Tumor

Search GEO for disease gene expression data for Sertoli Cell Tumor.

Pathways for Sertoli Cell Tumor

Pathways related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 INHA NR5A1

GO Terms for Sertoli Cell Tumor

Cellular components related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 9.16 CALB2 SYP
2 neuromuscular junction GO:0031594 8.96 PRKAR1A SYP
3 neuron projection GO:0043005 8.8 CALB2 SYP VIM

Biological processes related to Sertoli Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.43 INHA NR5A1 WT1
2 SMAD protein signal transduction GO:0060395 9.4 INHA VIM
3 adrenal gland development GO:0030325 9.37 NR5A1 WT1
4 tissue development GO:0009888 9.32 NR5A1 WT1
5 sex determination GO:0007530 9.16 NR5A1 WT1
6 positive regulation of male gonad development GO:2000020 8.96 NR5A1 WT1
7 negative regulation of female gonad development GO:2000195 8.62 NR5A1 WT1

Sources for Sertoli Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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