MCID: SRT003
MIFTS: 38

Sertoli-Leydig Cell Tumor

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Sertoli-Leydig Cell Tumor

MalaCards integrated aliases for Sertoli-Leydig Cell Tumor:

Name: Sertoli-Leydig Cell Tumor 12 51 41 14 69
Sertoli-Leydig Cell Tumor of Intermediate Differentiation 69
Sertoli-Leydig Cell Tumor of the Ovary 49
Sertoli-Leydig Cell Tumor of Ovary 69
Sertoli-Leydig Cell Tumors 49
Arrhenoblastoma of Ovary 49
Androblastoma of Ovary 49
Arrhenoblastoma 49

Classifications:



External Ids:

Disease Ontology 12 DOID:2997
MeSH 41 D018310
SNOMED-CT 64 34110004

Summaries for Sertoli-Leydig Cell Tumor

NIH Rare Diseases : 49 Sertoli-Leydig celltumors are a cancer that starts in the female ovaries. The cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. This type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. Sertoli-Leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. While they can be found in women of all age groups, they are most common in young women. Treatment involves surgery and chemotherapy or radiation if the cancer has spread. Because Sertoli-Leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good. Last updated: 3/25/2010

MalaCards based summary : Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of intermediate differentiation, is related to leydig cell tumor and gynandroblastoma, and has symptoms including hoarseness An important gene associated with Sertoli-Leydig Cell Tumor is AFP (Alpha Fetoprotein). The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and testis.

Related Diseases for Sertoli-Leydig Cell Tumor

Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 leydig cell tumor 31.9 AFP INSL3
2 gynandroblastoma 30.8 CALB2 DICER1
3 rete testis adenocarcinoma 30.5 AFP CALB2
4 mucinous adenocarcinoma 29.9 KRT7 MUC1
5 teratoma 29.8 AFP KRT7
6 cystadenoma 29.7 KRT7 MUC1 PGR
7 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.7
8 malignant sertoli-leydig cell tumor of the ovary 12.5
9 malignant sertoli-leydig cell tumor 12.3
10 alpha-fetoprotein deficiency 10.5
11 androgen insensitivity syndrome 10.4
12 multinodular goiter 10.3
13 goiter 10.3
14 rhabdomyosarcoma 10.3
15 complete androgen insensitivity syndrome 10.3
16 pineoblastoma 10.3 AFP DICER1
17 cystic nephroma 10.3 DICER1 PGR
18 rete testis neoplasm 10.3 AFP CALB2
19 sarcoma 10.3
20 amenorrhea 10.3
21 cervicitis 10.3
22 adenocarcinoma 10.3
23 mixed hepatoblastoma 10.3 AFP PGR
24 botryoid rhabdomyosarcoma 10.2 AFP DICER1
25 spermatocele 10.2 CALB2 PGR
26 pleomorphic lipoma 10.2 CALB2 PGR
27 malignant leydig cell tumor 10.2 CALB2 KRT7
28 kidney benign neoplasm 10.2 DICER1 KRT7
29 atypical choroid plexus papilloma 10.2 DICER1 KRT7
30 intrahepatic bile duct adenoma 10.2 AFP KRT7
31 hyperandrogenism 10.2
32 adenoma 10.2
33 ovarian germ cell cancer 10.2 AFP KRT7
34 intratubular embryonal carcinoma 10.2 AFP KRT7
35 clear cell adenofibroma 10.2 CALB2 KRT7
36 renal pelvis carcinoma 10.1 AFP KRT7
37 choriocarcinoma of the testis 10.1 AFP KRT7
38 seminal vesicle tumor 10.1 AFP KRT7
39 horseshoe kidney 10.1 CALB2 KRT7
40 ovarian endodermal sinus tumor 10.1 AFP KRT7
41 eccrine papillary adenocarcinoma 10.1 KRT7 PGR
42 female reproductive endometrioid cancer 10.1 KRT7 PGR
43 pericardium cancer 10.1 CALB2 KRT7
44 cribriform carcinoma 10.1 KRT7 PGR
45 oncocytic breast carcinoma 10.1 KRT7 PGR
46 benign metastasizing leiomyoma 10.1 KRT7 PGR
47 pancreatic serous cystadenoma 10.1 KRT7 PGR
48 adenoid basal cell carcinoma 10.1 KRT7 PGR
49 endodermal sinus tumor 10.1 AFP KRT7
50 corneal abscess 10.1 KRT7 PGR

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to Sertoli-Leydig Cell Tumor

Symptoms & Phenotypes for Sertoli-Leydig Cell Tumor

UMLS symptoms related to Sertoli-Leydig Cell Tumor:


hoarseness

Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

Drugs for Sertoli-Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
3
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
4
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
5
Etoposide Approved Phase 2 33419-42-0 36462
6
Bevacizumab Approved, Investigational Phase 2 216974-75-3
7 Albumin-Bound Paclitaxel Phase 2
8 Antimitotic Agents Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2
10 Anti-Bacterial Agents Phase 2
11 Antibiotics, Antitubercular Phase 2
12 Etoposide phosphate Phase 2
13 Topoisomerase Inhibitors Phase 2
14 Angiogenesis Inhibitors Phase 2
15 Angiogenesis Modulating Agents Phase 2
16 Antibodies Phase 2
17 Antibodies, Monoclonal Phase 2
18 Endothelial Growth Factors Phase 2
19 Immunoglobulins Phase 2
20 Mitogens Phase 2
21
Gemcitabine Approved Phase 1 95058-81-4 60750
22 Anti-Infective Agents Phase 1
23 Antimetabolites Phase 1
24 Antimetabolites, Antineoplastic Phase 1
25 Antiviral Agents Phase 1
26 Immunosuppressive Agents Phase 1
27
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
28
Dactinomycin Approved, Investigational 50-76-0 457193 2019
29
Doxorubicin Approved, Investigational 23214-92-8 31703
30
Ifosfamide Approved 3778-73-2 3690
31
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
32
Doxil Approved June 1999 31703
33 Isophosphamide mustard 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
4 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
5 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
6 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
9 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Sertoli-Leydig Cell Tumor

Cochrane evidence based reviews: sertoli-leydig cell tumor

Genetic Tests for Sertoli-Leydig Cell Tumor

Anatomical Context for Sertoli-Leydig Cell Tumor

MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

38
Ovary, Endothelial, Testis, Testes, Uterus, Thyroid, Skeletal Muscle

Publications for Sertoli-Leydig Cell Tumor

Articles related to Sertoli-Leydig Cell Tumor:

(show top 50) (show all 143)
# Title Authors Year
1
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
2
Case report: an identical twin with Sertoli-Leydig cell tumor. ( 29366348 )
2018
3
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature. ( 28751916 )
2017
4
Sertoli-Leydig cell tumor of the ovary masquerading as a mucinous adenocarcinoma: a frozen section pitfall. ( 29081925 )
2017
5
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
6
Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature. ( 28316852 )
2017
7
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. ( 28469526 )
2017
8
DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects. ( 27664536 )
2017
9
DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors. ( 28654427 )
2017
10
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. ( 29037807 )
2017
11
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
12
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
13
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
14
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
15
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
16
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
17
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
18
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
19
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
20
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
21
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. ( 26408257 )
2015
22
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
23
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. ( 24783104 )
2014
24
Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. ( 25027813 )
2014
25
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. ( 25299229 )
2014
26
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. ( 25926909 )
2014
27
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. ( 25002956 )
2014
28
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. ( 25032133 )
2014
29
Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. ( 24696734 )
2014
30
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
31
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review. ( 25296983 )
2014
32
Poorly differentiated ovarian sertoli-leydig cell tumor in a 16-year-old single woman: a case report and literature review. ( 23878752 )
2013
33
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. ( 22691037 )
2013
34
Fine needle aspiration cytology of Sertoli-Leydig cell tumors of ovary masquerading as dysgerminoma. ( 22102529 )
2013
35
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. ( 24328002 )
2013
36
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. ( 24333107 )
2013
37
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. ( 23173550 )
2013
38
First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease. ( 22633001 )
2012
39
Successful term pregnancies after laparoscopic excision of poorly differentiated Sertoli-Leydig cell tumor of the ovary. ( 22808364 )
2012
40
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. ( 21847587 )
2012
41
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. ( 22635079 )
2012
42
Ovarian Sertoli-Leydig cell tumor in a 9-month-old infant with special histologic pattern. ( 22443217 )
2012
43
Sertoli-Leydig cell tumor presenting hyperestrogenism in a postmenopausal woman: a case report and review of the literature. ( 23276568 )
2012
44
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. ( 23084689 )
2012
45
Retiform Sertoli-Leydig cell tumor of ovary in a 9-year-old girl: case report and review of the literature. ( 21347632 )
2011
46
Cytologic, immunocytologic, histopathologic and immunohistologic diagnosis of the poorly differentiated sertoli-leydig cell tumor. ( 21791911 )
2011
47
Management of metastatic ovarian Sertoli-Leydig cell tumor with sporadic multinodular goiter: a case report and literature review. ( 21919698 )
2011
48
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. ( 21205968 )
2011
49
The case reported as bilateral Sertoli-Leydig cell tumors in a 61-year-old woman with uterine aplasia may instead represent complete androgen insensitivity syndrome. ( 21623193 )
2011
50
Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary. ( 19674851 )
2010

Variations for Sertoli-Leydig Cell Tumor

Expression for Sertoli-Leydig Cell Tumor

Search GEO for disease gene expression data for Sertoli-Leydig Cell Tumor.

Pathways for Sertoli-Leydig Cell Tumor

GO Terms for Sertoli-Leydig Cell Tumor

Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ovulation from ovarian follicle GO:0001542 8.62 AFP PGR

Sources for Sertoli-Leydig Cell Tumor

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70 UMLS via Orphanet
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