MCID: SRT003
MIFTS: 48

Sertoli-Leydig Cell Tumor malady

Cancer category

Summaries for Sertoli-Leydig Cell Tumor

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43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Sertoli-leydig cell tumors are a cancer that starts in the female ovaries. the cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. this type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. while they can be found in women of all age groups, they are most common in young women. treatment involves surgery and chemotherapy or radiation if the cancer has spread. because sertoli-leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good. last updated: 3/25/2010

MalaCards: Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of the ovary, is related to sertoli cell tumor and androgen insensitivity syndrome. An important gene associated with Sertoli-Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are Mineralocorticoid biosynthesis and Androgen biosynthesis. The compounds dmrt and estrogen have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, adrenal gland and breast, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:64 Sertoli-Leydig cell tumour is a group of tumours composed of variable proportions of Sertoli cells,... more...

Aliases & Classifications for Sertoli-Leydig Cell Tumor

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 43NIH Rare Diseases, 57SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

sertoli-leydig cell tumor 8 10 45 61
sertoli-leydig cell tumor of the ovary 43
sertoli-leydig cell tumors 43
arrhenoblastoma of ovary 43
androblastoma of ovary 43
arrhenoblastoma 43


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Disease Ontology8 DOID:2997
SNOMED-CT57 34110004
MeSH35 D018310

Related Diseases for Sertoli-Leydig Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Sertoli-Leydig Cell Tumor family:

malignant sertoli-leydig cell tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli cell tumor32.0CALB2, SYP, MUC1, INHA, PGR, ENO2
2androgen insensitivity syndrome30.9SRY
3cystadenoma30.8INHA, KRT7, CEACAM3
4amenorrhea30.7SRY
5teratoma30.7ENO2, KRT7, AFP
6adenoma30.6HSD3BP4, CALB2, SYP, NR5A1, MUC1, CYP17A1
7adenocarcinoma30.6CALB2, WT1, AFP, SYP, CEACAM3, ENO2
8desmoplastic small round cell tumor30.4MUC1, WT1
9dysgerminoma30.4SRY, KRT7, INHA, AFP, WT1
10hyperandrogenism30.4HSD3B1, HSD3BP4, CYP17A1, INSL3
11adrenal adenoma30.4HSD3BP4, CALB2, MLANA, SYP, NR5A1, CYP17A1
12mucinous cystadenocarcinoma30.0MUC1, KRT7, CEACAM3
13malignant sertoli-leydig cell tumor10.6
14ovarian malignant sertoli-leydig cell tumor10.6
15complete androgen insensitivity syndrome10.6
16goiter, multinodular 1, with or without sertoli-leydig cell tumors10.6
17multinodular goiter10.5
18malignant sertoli cell tumor10.5
19rete testis adenocarcinoma10.3
20mucinous adenocarcinoma10.3
21ollier disease10.3
22breast adenoma10.3
23young syndrome10.3
24precocious puberty10.3
25gynandroblastoma10.3
26virilizing ovarian tumor10.3
27hematopoietic stem cell transplantation10.3
28papillary cystadenocarcinoma10.0
29luteoma10.0
30thyroid adenoma10.0
31cystic nephroma10.0DICER1
32hepatitis10.0AFP
33premature ovarian failure10.0INHA
34adenosarcoma10.0PGR
35liposarcoma10.0CALB2
36malignant pleural mesothelioma10.0CALB2
37ductal carcinoma in situ10.0PGR
38placental abruption10.0AFP
39melanotic neuroectodermal tumor10.0SYP
40hemangiopericytoma10.0MUC1
41hypertension10.0CYP17A1
42hepatitis c10.0AFP
43leukemia10.0WT1
44testicular disease10.0SRY
45bladder carcinoma10.0NR5A1
46von hippel-lindau disease10.0INHA
47insulin resistance10.0CYP17A1
48adenomatoid tumor10.0CALB2, WT1
49adenofibroma10.0CALB2, INHA
50hypogonadism10.0NR5A1

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to sertoli-leydig cell tumor

Clinical Features for Sertoli-Leydig Cell Tumor

Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Sertoli-Leydig Cell Tumor

Genetic Tests for Sertoli-Leydig Cell Tumor

Anatomical Context for Sertoli-Leydig Cell Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

33
Skeletal muscle, Adrenal gland, Breast, Ovary, Testis, Testis leydig

Animal Models for Sertoli-Leydig Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Sertoli-Leydig Cell Tumor

Sources:
51PubMed
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Articles related to Sertoli-Leydig Cell Tumor:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. (22691037)
2013
2
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. (24333107)
2013
3
Fine needle aspiration cytology of Sertoli-Leydig cell tumors of ovary masquerading as dysgerminoma. (22102529)
2013
4
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
5
Ovarian Sertoli-Leydig cell tumor in a 9-month-old infant with special histologic pattern. (22443217)
2012
6
The case reported as bilateral Sertoli-Leydig cell tumors in a 61-year-old woman with uterine aplasia may instead represent complete androgen insensitivity syndrome. (21623193)
2011
7
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. (21205968)
2011
8
Management of metastatic ovarian Sertoli-Leydig cell tumor with sporadic multinodular goiter: a case report and literature review. (21919698)
2011
9
Postpartum hemorrhage from ruptured Sertoli-Leydig cell tumor: a case report. (21043371)
2010
10
Recurrent alpha-fetoprotein secreting Sertoli-Leydig cell tumor of ovary with an unusual presentation. (19282570)
2009
11
Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. (19136796)
2009
12
Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokeratin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor. (19851210)
2009
13
Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature. (18382911)
2008
14
Ovarian Sertoli-Leydig cell tumor with heterologous gastrointestinal epithelium as a source of alpha-fetoprotein: a case report. (18588618)
2008
15
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
16
Immunohistochemical and ultrastructural analysis of a poorly differentiated pediatric age Sertoli-Leydig cell tumor. (17022971)
2007
17
Primary amenorrhea in a young Polish woman with complete androgen insensitivity syndrome and Sertoli-Leydig cell tumor: identification of a new androgen receptor gene mutation and evidence of aromatase hyperactivity and apoptosis dysregulation within the tumor. (17852420)
2007
18
Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. (17177833)
2006
19
Ovarian Sertoli-Leydig cell tumor of intermediate grade with heterologous elements of rhabdomyosarcoma. A case report and a review of the literature. (16979522)
2006
20
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
21
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
22
Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study. (14734221)
2004
23
Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. (11788622)
2002
24
Sertoli-Leydig cell tumor. (11205710)
2001
25
Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor. (11381376)
2001
26
Conservative management of Sertoli-Leydig cell tumor of the ovary. (9246972)
1997
27
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor. (9345364)
1997
28
Sertoli-Leydig cell tumor of the ovary: a case report with endocrinologic observations. (15251509)
1996
29
Late presentation of an alpha-fetoprotein secreting isolated large upper abdominal retroperitoneal Sertoli-Leydig cell tumor recurrence. (7534742)
1995
30
In vitro production of cyclic AMP and steroids from an ovarian Sertoli-Leydig cell tumor. Notes on clinical management. (7732806)
1995
31
Sertoli-Leydig cell testicular tumor: case report and review of sex cord/gonadal stromal tumor histogenesis. (1512847)
1992
32
A case of ovarian Sertoli-Leydig cell tumor associated with high serum alpha-fetoprotein (AFP) concentration]. (1698212)
1990
33
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
34
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
35
Steroid biosynthesis in the Sertoli-Leydig cell tumor: effects of insulin and luteinizing hormone. (2532472)
1989
36
Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor. (2844882)
1988
37
Mixed Sertoli-Leydig cell tumor and rete testis adenocarcinoma in rats treated with CdCl2. (2834860)
1988
38
Bilateral Sertoli-Leydig cell tumor with heterologous elements: report of an unusual case and review of the literature. (3732587)
1986
39
Demonstration of hydroxysteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study. (2984872)
1985
40
AFP-producing Sertoli-Leydig cell tumor of the ovary. (2409934)
1985
41
Arrested puberty associated with a Sertoli-Leydig cell tumor. (4003476)
1985
42
Sertoli-Leydig cell tumor of the ovary. (4019011)
1985
43
Steroid biosynthesis in the Sertoli-Leydig cell tumor tissue of the human ovary; enzymhistochemical and immunohistochemical studies. (6425925)
1984
44
Steroid metabolism in an androblastoma (Sertoli-Leydig cell tumor): a histopathological and biochemical study. (6327547)
1984
45
Sertoli-Leydig cell tumor of the ovary with heterologous elements and carcinoid: an immunohistochemical and ultrastructural study. (6367176)
1983
46
Sertoli-Leydig cell tumor of the ovary with teratomatous differentiation: clinicopathologic considerations. (7104958)
1982
47
Sertoli--Leydig cell tumor with endometroid differentiation. Case report and discussion of histogenesis. (7117116)
1982
48
Light and electron microscopic study of an intermediate sertoli-leydig cell tumor with a review of literatures in Japan. (1026031)
1976
49
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
50
Ultrastructure of a human chorionic gonadotropin-and adrenocorticotropin-responsive functioning Sertoli-Leydig cell tumor (type I). (4353887)
1973

Genetic Variations for Sertoli-Leydig Cell Tumor

Expression for genes affiliated with Sertoli-Leydig Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sertoli-Leydig Cell Tumor

Search GEO for disease gene expression data for Sertoli-Leydig Cell Tumor.

Pathways for genes affiliated with Sertoli-Leydig Cell Tumor

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0CYP17A1, HSD3B1
2
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10.0CYP17A1, HSD3B1
310.0PGR, INHA, NR5A1

Compounds for genes affiliated with Sertoli-Leydig Cell Tumor

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1dmrt4510.3WT1, NR5A1, SRY
2estrogen4510.2MYOG, NR5A1, CALB2
3trilostane45 1111.1HSD3B1, HSD3BP4, PGR
4reticulin4510.1MUC1, SYP, KRT7
5s 1004510.1ENO2, MUC1, SYP
617beta-hydroxysteroid459.9NR5A1, HSD3BP4, PGR, CYP17A1
7forskolin45 50 1111.9ENO2, CYP17A1, MYOG, WT1
8letrozole45 50 60 1112.9SYP, PGR, CYP17A1
9dexamethasone45 50 29 1112.9ENO2, HSD3BP4, AFP, CYP17A1
10estrone45 29 11 2412.8NR5A1, CYP17A1, HSD3BP4, PGR, AFP
11androstenedione45 2410.8CYP17A1, INHA, HSD3BP4, HSD3B1
12progestin459.8HSD3BP4, PGR, MUC1, CYP17A1
13chloramphenicol45 2 1111.7CYP17A1, AFP, WT1, THBD, MUC1
14silver459.7SYP, ENO2, SRY, CALB2, AFP
15mucicarmine459.7CEACAM3, CALB2, SYP, MUC1, KRT7
16mifepristone45 60 29 1112.7PGR, MUC1, AFP, HSD3BP4
17dbc-amp459.7THBD, ENO2, SYP, CYP17A1
18dmso459.7PGR, AFP, MUC1, ENO2, THBD
19butyrate459.7MYOG, CALB2
20hyaluronic acid45 2410.6WT1, CALB2, MUC1, THBD, ENO2
21diethylstilbestrol45 29 1111.6CYP17A1, AFP, PGR, NR5A1, INSL3, ENO2
22sialic acid459.6CEACAM3, AFP, MUC1, KRT7, ENO2
23cysteine459.5MYOG, THBD, SYP, SRY, MUC1, PGR
243beta-hydroxysteroid459.5HSD3BP4, PGR, HSD3B1, INHA, CYP17A1, NR5A1
25methotrexate45 50 1111.5CEACAM3, ENO2, AFP, PGR, KRT7, MUC1
26hydrogen45 2410.5THBD, CEACAM3, INHA, CYP17A1, SYP, AFP
27cyclic amp45 2410.4MUC1, SYP, HSD3BP4, NR5A1, INHA, INSL3
28glycogen45 2410.4ENO2, MUC1, THBD, SYP, KRT7, AFP
29oligonucleotide459.3THBD, SRY, NR5A1, INHA, CYP17A1, MYOG
30b 723459.2KRT7, MUC1, THBD, CALB2, WT1, AFP
31estradiol45 11 2411.2HSD3BP4, AFP, CYP17A1, MUC1, INHA, PGR
32leucine459.2SYP, SRY, ENO2, NR5A1, CYP17A1, THBD
33alanine459.1AFP, CEACAM3, SRY, INHA, INSL3, PGR
34thymidine45 2410.1CEACAM3, AFP, WT1, ENO2, CYP17A1, MUC1
35acth459.0INHA, NR5A1, SYP, HSD3BP4, CYP17A1, ENO2
36creatinine459.0AFP, MYOG, SYP, MUC1, WT1, THBD
37ribonucleic acid458.9HSD3BP4, ENO2, PGR, INHA, MUC1, WT1
38hematoxylin458.9CALB2, SYP, CEACAM3, ENO2, KRT7, MLANA
39nitric oxide45 11 2410.9CEACAM3, ENO2, MUC1, MYOG, SYP, WT1
40serine458.8NR5A1, MUC1, THBD, CYP17A1, MYOG, SRY
41lipid458.8THBD, KRT7, AFP, MUC1, MYOG, SYP
42vegf458.6PGR, MYOG, AFP, ENO2, THBD, KRT7
43cholesterol45 29 11 2411.6HSD3BP4, HSD3B1, SYP, NR5A1, ENO2, CEACAM3
44retinoic acid45 249.5CYP17A1, ENO2, KRT7, THBD, PGR, MUC1
45tyrosine458.0ENO2, CALB2, WT1, AFP, SYP, MYOG
46calcium45 50 11 2411.0HSD3BP4, MYOG, SYP, CALB2, AFP, CYP17A1
47paraffin458.0AFP, CALB2, WT1, MLANA, CEACAM3, SYP
48testosterone45 60 11 2410.7MYOG, ENO2, HSD3B1, HSD3BP4, CALB2, WT1
49progesterone45 60 29 11 2411.6ENO2, KRT7, THBD, PGR, INHA, CYP17A1
50steroid457.6NR5A1, SYP, AFP, WT1, CALB2, HSD3BP4

GO Terms for genes affiliated with Sertoli-Leydig Cell Tumor

Sources:
16Gene Ontology
See all sources

Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of female gonad developmentGO:200019510.3WT1, NR5A1
2ovulation from ovarian follicleGO:00154210.2PGR, AFP
3progesterone metabolic processGO:04244810.2CYP17A1, AFP
4positive regulation of male gonad developmentGO:200002010.1SRY, NR5A1, WT1
5adrenal gland developmentGO:03032510.1WT1, CYP17A1, NR5A1
6glucocorticoid biosynthetic processGO:00670410.0CYP17A1, HSD3B1
7androgen biosynthetic processGO:00670210.0HSD3B1, CYP17A1
8male gonad developmentGO:0085849.8NR5A1, INSL3, SRY, WT1, INHA
9cellular response to gonadotropin stimulusGO:0713719.8WT1, CYP17A1
10cell-cell signalingGO:0072679.7NR5A1, PGR, INSL3, INHA

Products for genes affiliated with Sertoli-Leydig Cell Tumor

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Sources for Sertoli-Leydig Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet