MCID: SRT003
MIFTS: 36

Sertoli-Leydig Cell Tumor

Categories: Rare diseases, Cancer diseases, Reproductive diseases

Aliases & Classifications for Sertoli-Leydig Cell Tumor

MalaCards integrated aliases for Sertoli-Leydig Cell Tumor:

Name: Sertoli-Leydig Cell Tumor 12 52 42 14 69
Sertoli-Leydig Cell Tumor of Intermediate Differentiation 69
Sertoli-Leydig Cell Tumor of the Ovary 50
Sertoli-Leydig Cell Tumor of Ovary 69
Sertoli-Leydig Cell Tumors 50
Arrhenoblastoma of Ovary 50
Androblastoma of Ovary 50
Arrhenoblastoma 50

Classifications:



External Ids:

Disease Ontology 12 DOID:2997
MeSH 42 D018310
SNOMED-CT 64 34110004
UMLS 69 C0206723

Summaries for Sertoli-Leydig Cell Tumor

NIH Rare Diseases : 50 sertoli-leydig celltumors are a cancer that starts in the female ovaries. the cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. this type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. while they can be found in women of all age groups, they are most common in young women. treatment involves surgery and chemotherapy or radiation if the cancer has spread. because sertoli-leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good. last updated: 3/25/2010

MalaCards based summary : Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of intermediate differentiation, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and malignant sertoli-leydig cell tumor of ovary, and has symptoms including hoarseness An important gene associated with Sertoli-Leydig Cell Tumor is AFP (Alpha Fetoprotein). The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and testis, and related phenotypes are endocrine/exocrine gland and neoplasm

Related Diseases for Sertoli-Leydig Cell Tumor

Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
id Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.6
2 malignant sertoli-leydig cell tumor of ovary 12.3
3 malignant sertoli-leydig cell tumor 12.2
4 leydig cell tumor 11.0
5 hairy palms and soles 10.6 CALB2 DICER1
6 pneumothorax 10.5 AFP DICER1
7 conjunctivochalasis 10.4 DICER1 WT1
8 sphenoid sinus squamous cell carcinoma 10.4 AFP CALB2
9 thymus lipoma 10.4 CALB2 WT1
10 urethral villous adenoma 10.4 AFP CALB2
11 uremia 10.4 CALB2 WT1
12 subvalvular aortic stenosis 10.4 AFP PGR
13 gingival hypertrophy 10.4 AFP WT1
14 uveal melanoma 10.4 AFP WT1
15 cutaneous liposarcoma 10.4 CALB2 WT1
16 trachea sarcoma 10.3 CALB2 PGR
17 mesenteric vascular occlusion 10.3 CALB2 WT1
18 kidney lipoma 10.3 CALB2 PGR
19 congenital pulmonary alveolar proteinosis 10.3 AFP WT1
20 arteriolosclerosis 10.3 CALB2 WT1
21 iris spindle cell melanoma 10.3 CALB2 MUC1
22 plantar fasciitis 10.3 CALB2 WT1
23 androgen insensitivity 10.3
24 chronic neutrophilic leukemia 10.3 CALB2 MUC1
25 avian influenza 10.3 CALB2 WT1
26 breast myoepithelial neoplasm 10.3 PGR WT1
27 hypersensitivity reaction type iii disease 10.3 AFP PGR
28 lymphangiosarcoma 10.3 CALB2 MUC1
29 proliferative type fibrocystic change of breast 10.3 CALB2 MUC1
30 kallmann syndrome 10.3 PGR WT1
31 perivascular epithelioid cell tumor 10.3 CALB2 WT1
32 rhabdomyosarcoma 10.2
33 complete androgen insensitivity syndrome 10.2
34 luminal breast carcinoma 10.2 AFP MUC1
35 bile duct mucoepidermoid carcinoma 10.2 MUC1 PGR
36 cervical neuroblastoma 10.2 CALB2 WT1
37 subglottis verrucous carcinoma 10.2 MUC1 PGR
38 multinodular goiter 10.2
39 sarcoma 10.2
40 goiter 10.2
41 amenorrhea 10.2
42 cervicitis 10.2
43 cystadenoma 10.2
44 epilepsy with generalized tonic-clonic seizures 10.2 CALB2 MUC1
45 mannose-binding lectin protein deficiency 10.2 MUC1 PGR
46 pyoderma 10.2 MUC1 PGR
47 mediastinal osteogenic sarcoma 10.2 CALB2 MUC1
48 bladder colloid adenocarcinoma 10.2 MUC1 PGR
49 gastroesophageal junction adenocarcinoma 10.2 MUC1 PGR
50 epithelioid sarcoma 10.2 MUC1 WT1

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to Sertoli-Leydig Cell Tumor

Symptoms & Phenotypes for Sertoli-Leydig Cell Tumor

UMLS symptoms related to Sertoli-Leydig Cell Tumor:


hoarseness

MGI Mouse Phenotypes related to Sertoli-Leydig Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 WT1 AFP DICER1 INSL3 PGR
2 neoplasm MP:0002006 9.26 AFP DICER1 PGR WT1
3 reproductive system MP:0005389 9.02 AFP DICER1 INSL3 PGR WT1

Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

Drugs for Sertoli-Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
3
Bleomycin Approved Phase 2 11056-06-7 5360373
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Etoposide Approved Phase 2 33419-42-0 36462
6
Bevacizumab Approved, Investigational Phase 2 216974-75-3
7 Albumin-Bound Paclitaxel Phase 2
8 Antimitotic Agents Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2
10 Anti-Bacterial Agents Phase 2
11 Antibiotics, Antitubercular Phase 2
12 Etoposide phosphate Phase 2
13 Topoisomerase Inhibitors Phase 2
14 Angiogenesis Inhibitors Phase 2
15 Angiogenesis Modulating Agents Phase 2
16 Antibodies Phase 2
17 Antibodies, Monoclonal Phase 2
18 Endothelial Growth Factors Phase 2
19 Immunoglobulins Phase 2
20 Mitogens Phase 2
21
Gemcitabine Approved Phase 1 95058-81-4 60750
22 Anti-Infective Agents Phase 1
23 Antimetabolites Phase 1
24 Antimetabolites, Antineoplastic Phase 1
25 Antiviral Agents Phase 1
26 Immunosuppressive Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
4 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
5 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
6 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Sertoli-Leydig Cell Tumor

Cochrane evidence based reviews: sertoli-leydig cell tumor

Genetic Tests for Sertoli-Leydig Cell Tumor

Anatomical Context for Sertoli-Leydig Cell Tumor

MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

39
Ovary, Endothelial, Testis, Testes, Skeletal Muscle, Thyroid, Uterus

Publications for Sertoli-Leydig Cell Tumor

Articles related to Sertoli-Leydig Cell Tumor:

(show top 50) (show all 138)
id Title Authors Year
1
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature. ( 28751916 )
2017
2
DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects. ( 27664536 )
2017
3
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. ( 28469526 )
2017
4
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
5
Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature. ( 28316852 )
2017
6
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
7
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
8
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
9
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
10
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
11
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
12
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
13
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
14
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
15
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
16
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. ( 26408257 )
2015
17
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
18
Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. ( 25027813 )
2014
19
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. ( 25002956 )
2014
20
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. ( 25926909 )
2014
21
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review. ( 25296983 )
2014
22
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
23
Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. ( 24696734 )
2014
24
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. ( 25032133 )
2014
25
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. ( 24783104 )
2014
26
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. ( 25299229 )
2014
27
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. ( 24333107 )
2013
28
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. ( 22691037 )
2013
29
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. ( 23173550 )
2013
30
Fine needle aspiration cytology of Sertoli-Leydig cell tumors of ovary masquerading as dysgerminoma. ( 22102529 )
2013
31
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. ( 24328002 )
2013
32
Poorly differentiated ovarian sertoli-leydig cell tumor in a 16-year-old single woman: a case report and literature review. ( 23878752 )
2013
33
First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease. ( 22633001 )
2012
34
Successful term pregnancies after laparoscopic excision of poorly differentiated Sertoli-Leydig cell tumor of the ovary. ( 22808364 )
2012
35
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. ( 23084689 )
2012
36
Sertoli-Leydig cell tumor presenting hyperestrogenism in a postmenopausal woman: a case report and review of the literature. ( 23276568 )
2012
37
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. ( 21847587 )
2012
38
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. ( 22635079 )
2012
39
Ovarian Sertoli-Leydig cell tumor in a 9-month-old infant with special histologic pattern. ( 22443217 )
2012
40
Retiform Sertoli-Leydig cell tumor of ovary in a 9-year-old girl: case report and review of the literature. ( 21347632 )
2011
41
Management of metastatic ovarian Sertoli-Leydig cell tumor with sporadic multinodular goiter: a case report and literature review. ( 21919698 )
2011
42
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. ( 21205968 )
2011
43
Cytologic, immunocytologic, histopathologic and immunohistologic diagnosis of the poorly differentiated sertoli-leydig cell tumor. ( 21791911 )
2011
44
The case reported as bilateral Sertoli-Leydig cell tumors in a 61-year-old woman with uterine aplasia may instead represent complete androgen insensitivity syndrome. ( 21623193 )
2011
45
Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. ( 19957213 )
2010
46
7,12-dimethylbenz[a]anthracene induces sertoli-leydig-cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclohexene diepoxide. ( 20158943 )
2010
47
Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements. ( 20407320 )
2010
48
Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary. ( 19674851 )
2010
49
Postpartum hemorrhage from ruptured Sertoli-Leydig cell tumor: a case report. ( 21043371 )
2010
50
Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case report. ( 20736765 )
2010

Variations for Sertoli-Leydig Cell Tumor

Expression for Sertoli-Leydig Cell Tumor

Search GEO for disease gene expression data for Sertoli-Leydig Cell Tumor.

Pathways for Sertoli-Leydig Cell Tumor

GO Terms for Sertoli-Leydig Cell Tumor

Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 epithelial cell differentiation GO:0030855 8.96 MUC1 WT1
2 ovulation from ovarian follicle GO:0001542 8.62 AFP PGR

Sources for Sertoli-Leydig Cell Tumor

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