MCID: SRT003
MIFTS: 51

Sertoli-Leydig Cell Tumor malady

Cancer diseases category

Summaries for Sertoli-Leydig Cell Tumor

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Sertoli-leydig cell tumors are a cancer that starts in the female ovaries. the cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. this type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. while they can be found in women of all age groups, they are most common in young women. treatment involves surgery and chemotherapy or radiation if the cancer has spread. because sertoli-leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good. last updated: 3/25/2010

MalaCards: Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of the ovary, is related to sertoli cell tumor and leydig cell tumor. An important gene associated with Sertoli-Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways are Mineralocorticoid biosynthesis and Androgen biosynthesis. The compounds dmrt and estrogen have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and skeletal muscle, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Wikipedia:63 Sertoli-Leydig cell tumour is a group of tumours composed of variable proportions of Sertoli cells,... more...

Aliases & Classifications for Sertoli-Leydig Cell Tumor

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

sertoli-leydig cell tumor 8 10 44 60
sertoli-leydig cell tumor of the ovary 42
sertoli-leydig cell tumors 42
arrhenoblastoma of ovary 42
androblastoma of ovary 42
arrhenoblastoma 42


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Disease Ontology8 DOID:2997
SNOMED-CT56 34110004
MeSH34 D018310

Related Diseases for Sertoli-Leydig Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli cell tumor31.9CALB2, SYP, MUC1, INHA, PGR, ENO2
2leydig cell tumor31.9INHA, HSD3B1, HSD3BP4, CALB2, NR5A1, CYP17A1
3androgen insensitivity syndrome30.9SRY
4cystadenoma30.8INHA, KRT7, CEACAM3
5sarcoma30.7CALB2, WT1, MLANA, MYOG, MUC1, ENO2
6amenorrhea30.6SRY
7rhabdomyosarcoma30.6CALB2, WT1, MYOG, INHA, ENO2
8adenoma30.6HSD3BP4, CALB2, SYP, NR5A1, MUC1, CYP17A1
9adenocarcinoma30.6CALB2, WT1, AFP, SYP, CEACAM3, ENO2
10hyperandrogenism30.4HSD3B1, HSD3BP4, CYP17A1, INSL3
11adrenal adenoma30.4HSD3BP4, CALB2, MLANA, SYP, NR5A1, CYP17A1
12cystadenocarcinoma29.9CEACAM3, MUC1
13mucinous cystadenocarcinoma29.9MUC1, KRT7, CEACAM3
14malignant sertoli-leydig cell tumor10.6
15goiter, multinodular 1, with or without sertoli-leydig cell tumors10.5
16ovarian malignant sertoli-leydig cell tumor10.5
17multinodular goiter10.4
18malignant sertoli cell tumor10.4
19cervicitis10.4
20goiter10.4
21malignant leydig cell tumor10.4
22ovarian cystadenoma10.4
23ovarian disease10.4
24rete testis adenocarcinoma10.3
25mucinous adenocarcinoma10.3
26breast adenoma10.3
27breast disease10.3
28cystic teratoma10.3
29dysgerminoma of ovary10.3
30mature teratoma10.3
31ovary adenocarcinoma10.3
32vaginitis10.3
33image syndrome10.3
34cystic nephroma10.0DICER1
35hepatitis10.0AFP
36premature ovarian failure10.0INHA
37adenosarcoma10.0PGR
38liposarcoma10.0CALB2
39malignant pleural mesothelioma10.0CALB2
40ductal carcinoma in situ10.0PGR
41placental abruption10.0AFP
42melanotic neuroectodermal tumor10.0SYP
43hemangiopericytoma10.0MUC1
44hypertension10.0CYP17A1
45hepatitis c10.0AFP
46leukemia10.0WT1
47testicular disease10.0SRY
48bladder carcinoma10.0NR5A1
49von hippel-lindau disease10.0INHA
50insulin resistance10.0CYP17A1

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to sertoli-leydig cell tumor

Clinical Features for Sertoli-Leydig Cell Tumor

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Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sertoli-Leydig Cell Tumor

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Anatomical Context for Sertoli-Leydig Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

32
Ovary, Testis, Skeletal muscle, Breast

Animal Models for Sertoli-Leydig Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sertoli-Leydig Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7WT1, AFP, INHA, SRY
2MP:00053899.4WT1, AFP, NR5A1, INHA, INSL3, SRY
3MP:00053769.1AFP, NR5A1, MYOG, CYP17A1, PGR, THBD
4MP:00028738.6THBD, CALB2, WT1, DICER1, SYP, NR5A1
5MP:00053868.2CALB2, DICER1, AFP, NR5A1, MYOG, CYP17A1

Publications for Sertoli-Leydig Cell Tumor

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50PubMed
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Articles related to Sertoli-Leydig Cell Tumor:

(show top 50)    (show all 113)
idTitleAuthorsYear
1
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. (22691037)
2013
2
Poorly differentiated ovarian sertoli-leydig cell tumor in a 16-year-old single woman: a case report and literature review. (23878752)
2013
3
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. (23173550)
2013
4
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
5
Successful term pregnancies after laparoscopic excision of poorly differentiated Sertoli-Leydig cell tumor of the ovary. (22808364)
2012
6
Sertoli-Leydig cell tumor presenting hyperestrogenism in a postmenopausal woman: a case report and review of the literature. (23276568)
2012
7
The case reported as bilateral Sertoli-Leydig cell tumors in a 61-year-old woman with uterine aplasia may instead represent complete androgen insensitivity syndrome. (21623193)
2011
8
Retiform Sertoli-Leydig cell tumor of ovary in a 9-year-old girl: case report and review of the literature. (21347632)
2011
9
Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary. (19674851)
2010
10
Metastatic rhabdomyosarcomatous elements, mimicking a primary sarcoma, in the omentum, from a poorly differentiated ovarian Sertoli-Leydig cell tumor in a young girl: an unusual presentation with a literature review. (19805972)
2009
11
Sertoli-Leydig cell tumor of the testis in a Sprague-Dawley rat. (19049257)
2008
12
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
13
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
14
Immunohistochemical and ultrastructural analysis of a poorly differentiated pediatric age Sertoli-Leydig cell tumor. (17022971)
2007
15
Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors). (17414107)
2007
16
A case of Sertoli-Leydig cell tumor in a postmenopausal woman. (16445673)
2006
17
Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors. (16175078)
2005
18
Ovarian Sertoli-Leydig cell tumor, endometrioid-like yolk sac tumor, and Y-chromosomal material. (12759534)
2003
19
Ovarian Sertoli-Leydig cell tumor of intermediate differentiation with immature skeletal muscle heterologous elements. (12648187)
2003
20
Ossifying well-differentiated Sertoli-Leydig cell tumor of the ovary. (10684379)
2000
21
Relaxin-like factor expression in a human ovarian Sertoli-Leydig cell tumor. (10519633)
1999
22
Hepatocytic differentiation in retiform Sertoli-Leydig cell tumors: distinguishing a heterologous element from Leydig cells. (10374766)
1999
23
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor. (9345364)
1997
24
Ovarian Sertoli-Leydig cell tumor: a SRY gene-independent pathway of pseudomale gonadal differentiation. (9343329)
1997
25
Ovarian serous cystadenoma associated with Sertoli-Leydig cell tumor--a case report. (8703377)
1996
26
Ovarian Sertoli-Leydig cell tumor in an amenorrheic hirsute patient. (8828265)
1996
27
Sertoli-Leydig cell tumor of the ovary: a clinicopathologic study of 10 cases. (8750520)
1996
28
Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)
1995
29
Ovarian Sertoli-Leydig cell tumor with retiform pattern. (8771159)
1995
30
Analysis for steroid production of a Sertoli-Leydig cell tumor. (8314152)
1994
31
Ovarian Sertoli-Leydig cell tumor: success with salvage therapy. (11578343)
1993
32
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
33
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
34
An unusual hormone pattern in a virilized woman affected by Sertoli-Leydig cell tumor. Report of a case. (2694756)
1989
35
An ovarian Sertoli-Leydig cell tumor with heterologous mucinous gland and NSE-immunoreactive-cell. (2457358)
1988
36
Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor. (2844882)
1988
37
Raised serum alpha-fetoprotein in Sertoli-Leydig cell tumor (androblastoma) of ovary: report of two cases. (2437064)
1987
38
Bilateral Sertoli-Leydig cell tumor with heterologous elements: report of an unusual case and review of the literature. (3732587)
1986
39
Granulosa cell tumor of the ovary with Sertoli-Leydig cell tumor components (gynandroblastoma). (4056537)
1985
40
Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein. (6206735)
1984
41
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
42
Sertoli-Leydig cell tumor of the ovary with teratomatous differentiation: clinicopathologic considerations. (7104958)
1982
43
Ovarian Sertoli-Leydig cell tumor with hyperoestrinism. (6261444)
1981
44
Sertoli-Leydig cell tumor in a chimpanzee. (190468)
1976
45
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
46
Ultrastructure of a human chorionic gonadotropin-and adrenocorticotropin-responsive functioning Sertoli-Leydig cell tumor (type I). (4353887)
1973
47
Ultrastructure of a virilizing ovarian sertoli-leydig cell. Tumor with familial incidence. (4709959)
1973
48
Ultrastructure of an intermediate Sertoli-Leydig cell tumor. A histogenetic misnomer. (4311418)
1969
49
Ultrastructure of ovarian stromal cell tumors. Sertoli-Leydig cell tumor and lipid cell tumor. (5681434)
1968
50
A RARE CASE OF PRECOCIOUS PSEUDOPUBERTY DUE TO A SERTOLI-LEYDIG CELL TUMOR ORIGINATING FROM THE LEFT FALLOPIAN TUBE. (14087606)
1963

Genetic Variations for Sertoli-Leydig Cell Tumor

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Expression for genes affiliated with Sertoli-Leydig Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sertoli-Leydig Cell Tumor

Search GEO for disease gene expression data for Sertoli-Leydig Cell Tumor.

Pathways for genes affiliated with Sertoli-Leydig Cell Tumor

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53Reactome, 37NCBI BioSystems Database
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Pathways related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0CYP17A1, HSD3B1
2
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10.0CYP17A1, HSD3B1
310.0PGR, INHA, NR5A1

Compounds for genes affiliated with Sertoli-Leydig Cell Tumor

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1dmrt4410.3WT1, NR5A1, SRY
2estrogen4410.2MYOG, NR5A1, CALB2
3trilostane44 1111.1HSD3B1, HSD3BP4, PGR
4reticulin4410.1MUC1, SYP, KRT7
5s 1004410.1ENO2, MUC1, SYP
617beta-hydroxysteroid449.9NR5A1, HSD3BP4, PGR, CYP17A1
7forskolin44 49 1111.9ENO2, CYP17A1, MYOG, WT1
8letrozole44 49 59 1112.9SYP, PGR, CYP17A1
9dexamethasone44 49 28 1112.9ENO2, HSD3BP4, AFP, CYP17A1
10estrone44 28 11 2412.8NR5A1, CYP17A1, HSD3BP4, PGR, AFP
11androstenedione44 2410.8CYP17A1, INHA, HSD3BP4, HSD3B1
12progestin449.8HSD3BP4, PGR, MUC1, CYP17A1
13chloramphenicol44 2 1111.7CYP17A1, AFP, WT1, THBD, MUC1
14silver449.7SYP, ENO2, SRY, CALB2, AFP
15mucicarmine449.7CEACAM3, CALB2, SYP, MUC1, KRT7
16mifepristone44 59 28 1112.7PGR, MUC1, AFP, HSD3BP4
17dbc-amp449.7THBD, ENO2, SYP, CYP17A1
18dmso449.7PGR, AFP, MUC1, ENO2, THBD
19butyrate449.7MYOG, CALB2
20hyaluronic acid44 2410.6WT1, CALB2, MUC1, THBD, ENO2
21diethylstilbestrol44 28 1111.6CYP17A1, AFP, PGR, NR5A1, INSL3, ENO2
22sialic acid449.6CEACAM3, AFP, MUC1, KRT7, ENO2
23cysteine449.5MYOG, THBD, SYP, SRY, MUC1, PGR
243beta-hydroxysteroid449.5HSD3BP4, PGR, HSD3B1, INHA, CYP17A1, NR5A1
25methotrexate44 49 1111.5CEACAM3, ENO2, AFP, PGR, KRT7, MUC1
26hydrogen44 2410.5THBD, CEACAM3, INHA, CYP17A1, SYP, AFP
27cyclic amp44 2410.4MUC1, SYP, HSD3BP4, NR5A1, INHA, INSL3
28glycogen44 2410.4ENO2, MUC1, THBD, SYP, KRT7, AFP
29oligonucleotide449.3THBD, SRY, NR5A1, INHA, CYP17A1, MYOG
30b 723449.2KRT7, MUC1, THBD, CALB2, WT1, AFP
31estradiol44 11 2411.2HSD3BP4, AFP, CYP17A1, MUC1, INHA, PGR
32leucine449.2SYP, SRY, ENO2, NR5A1, CYP17A1, THBD
33alanine449.1AFP, CEACAM3, SRY, INHA, INSL3, PGR
34thymidine44 2410.1CEACAM3, AFP, WT1, ENO2, CYP17A1, MUC1
35acth449.0INHA, NR5A1, SYP, HSD3BP4, CYP17A1, ENO2
36creatinine449.0AFP, MYOG, SYP, MUC1, WT1, THBD
37ribonucleic acid448.9HSD3BP4, ENO2, PGR, INHA, MUC1, WT1
38hematoxylin448.9CALB2, SYP, CEACAM3, ENO2, KRT7, MLANA
39nitric oxide44 11 2410.9CEACAM3, ENO2, MUC1, MYOG, SYP, WT1
40serine448.8NR5A1, MUC1, THBD, CYP17A1, MYOG, SRY
41lipid448.8THBD, KRT7, AFP, MUC1, MYOG, SYP
42vegf448.6PGR, MYOG, AFP, ENO2, THBD, KRT7
43cholesterol44 28 11 2411.6HSD3BP4, HSD3B1, SYP, NR5A1, ENO2, CEACAM3
44retinoic acid44 249.5CYP17A1, ENO2, KRT7, THBD, PGR, MUC1
45tyrosine448.0ENO2, CALB2, WT1, AFP, SYP, MYOG
46calcium44 49 11 2411.0HSD3BP4, MYOG, SYP, CALB2, AFP, CYP17A1
47paraffin448.0AFP, CALB2, WT1, MLANA, CEACAM3, SYP
48testosterone44 59 11 2410.7MYOG, ENO2, HSD3B1, HSD3BP4, CALB2, WT1
49progesterone44 59 28 11 2411.6ENO2, KRT7, THBD, PGR, INHA, CYP17A1
50steroid447.6NR5A1, SYP, AFP, WT1, CALB2, HSD3BP4

GO Terms for genes affiliated with Sertoli-Leydig Cell Tumor

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16Gene Ontology
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Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of female gonad developmentGO:200019510.3NR5A1, WT1
2ovulation from ovarian follicleGO:00154210.2PGR, AFP
3progesterone metabolic processGO:04244810.2AFP, CYP17A1
4positive regulation of male gonad developmentGO:200002010.1WT1, NR5A1, SRY
5cellular response to gonadotropin stimulusGO:07137110.1CYP17A1, WT1
6adrenal gland developmentGO:03032510.1CYP17A1, NR5A1, WT1
7glucocorticoid biosynthetic processGO:00670410.0CYP17A1, HSD3B1
8male gonad developmentGO:0085849.8SRY, INSL3, INHA, NR5A1, WT1
9androgen biosynthetic processGO:0067029.7CYP17A1, HSD3B1
10cell-cell signalingGO:0072679.7NR5A1, INHA, INSL3, PGR

Products for genes affiliated with Sertoli-Leydig Cell Tumor

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Sources for Sertoli-Leydig Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet