MCID: SRT003
MIFTS: 48

Sertoli-Leydig Cell Tumor malady

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Summaries for Sertoli-Leydig Cell Tumor

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Sertoli-leydig cell tumors are a cancer that starts in the female ovaries. the cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. this type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. while they can be found in women of all age groups, they are most common in young women. treatment involves surgery and chemotherapy or radiation if the cancer has spread. because sertoli-leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good. last updated: 3/25/2010

MalaCards: Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of the ovary, is related to leydig cell tumor and cystadenoma. An important gene associated with Sertoli-Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways is Ovarian Infertility Genes. The compounds 3beta-hydroxysteroid and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and skeletal muscle, and related mouse phenotypes are immune system and liver/biliary system.

Wikipedia:65 Sertoli?Leydig cell tumour is a group of tumours composed of variable proportions of Sertoli cells,... more...

Aliases & Classifications for Sertoli-Leydig Cell Tumor

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

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Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

sertoli-leydig cell tumor 8 10 45 62
sertoli-leydig cell tumor of the ovary 43
sertoli-leydig cell tumors 43
arrhenoblastoma of ovary 43
androblastoma of ovary 43
arrhenoblastoma 43


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Disease Ontology8 DOID:2997
SNOMED-CT58 34110004
MeSH35 D018310

Related Diseases for Sertoli-Leydig Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1leydig cell tumor32.2INHA
2cystadenoma31.0INHA
3rhabdomyosarcoma30.7WT1, INHA
4desmoplastic small round cell tumor30.5MUC1, WT1
5adenocarcinoma30.5AFP, PGR, INHA, WT1, MUC1
6dysgerminoma30.4INHA, WT1, AFP
7androgen insensitivity syndrome10.6
8sarcoma10.6
9complete androgen insensitivity syndrome10.6
10goiter, multinodular 1, with or without sertoli-leydig cell tumors10.6
11ovarian malignant sertoli-leydig cell tumor10.6
12multinodular goiter10.5
13malignant sertoli-leydig cell tumor10.5
14amenorrhea10.5
15adenoma10.5
16cervicitis10.5
17goiter10.5
18hyperandrogenism10.3
19mucinous adenocarcinoma10.3
20rete testis adenocarcinoma10.3
21adrenal adenoma10.3
22breast adenoma10.3
23cystic teratoma10.3
24vaginitis10.3
25granulosa cell tumor of the ovary10.3
26gynandroblastoma10.3
27precocious puberty10.3
28teratoma10.3
29hematopoietic stem cell transplantation10.3
30cystic nephroma10.1DICER1
31adenofibroma10.1INHA
32adenosarcoma10.1PGR
33secretory meningioma10.1MUC1
34cystadenocarcinoma10.1MUC1
35metanephric adenoma10.1WT1
36hemihypertrophy10.1WT1
37adenomatoid tumor10.1WT1
38germinoma10.0INHA, AFP
39endodermal sinus tumor10.0INHA, AFP
40endometrial stromal sarcoma10.0PGR, INHA
41gynecomastia10.0INHA, PGR
42testicular cancer10.0AFP, INHA
43mammary paget's disease10.0MUC1, PGR
44spindle cell carcinoma10.0MUC1, PGR
45hemangioblastoma10.0INHA, MUC1
46chordoma10.0MUC1, INHA
47primary hyperoxaluria10.0WT1
48seminoma10.0INHA, AFP
49luteoma10.0
50thyroiditis10.0

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to sertoli-leydig cell tumor

Symptoms for Sertoli-Leydig Cell Tumor

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Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Sertoli-Leydig Cell Tumor

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Anatomical Context for Sertoli-Leydig Cell Tumor

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33MalaCards
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MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

33
Ovary, Testis, Skeletal muscle, Breast

Animal Models for Sertoli-Leydig Cell Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Sertoli-Leydig Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.3WT1, DICER1, PGR, INHA
2MP:00053708.2WT1, DICER1, MUC1, INHA
3MP:00053858.2INHA, PGR, DICER1, WT1
4MP:00020068.1INHA, AFP, PGR, MUC1, DICER1
5MP:00053978.0INHA, PGR, DICER1, WT1
6MP:00053897.9INHA, AFP, PGR, DICER1, WT1
7MP:00028737.8INHA, PGR, MUC1, DICER1, WT1
8MP:00107687.7INHA, AFP, PGR, DICER1, WT1
9MP:00053797.3WT1, DICER1, MUC1, PGR, AFP, INHA
10MP:00053767.3INHA, AFP, PGR, MUC1, DICER1, WT1

Publications for Sertoli-Leydig Cell Tumor

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52PubMed
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Articles related to Sertoli-Leydig Cell Tumor:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. (24328002)
2013
2
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
3
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
4
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. (22635079)
2012
5
First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease. (22633001)
2012
6
Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case report. (20736765)
2010
7
Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements. (20407320)
2010
8
Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. (19957213)
2010
9
Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. (19289327)
2009
10
Recurrent alpha-fetoprotein secreting Sertoli-Leydig cell tumor of ovary with an unusual presentation. (19282570)
2009
11
Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. (19136796)
2009
12
Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokeratin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor. (19851210)
2009
13
Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature. (18382911)
2008
14
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
15
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
16
Immunohistochemical and ultrastructural analysis of a poorly differentiated pediatric age Sertoli-Leydig cell tumor. (17022971)
2007
17
Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. (17177833)
2006
18
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
19
Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors. (16175078)
2005
20
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
21
Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study. (14734221)
2004
22
Ovarian Sertoli-Leydig cell tumor, endometrioid-like yolk sac tumor, and Y-chromosomal material. (12759534)
2003
23
Sertoli Leydig cell tumor with heterologous gastrointestinal epithelium: a case report. (15027740)
2003
24
Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. (11788622)
2002
25
Ossifying well-differentiated Sertoli-Leydig cell tumor of the ovary. (10684379)
2000
26
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
27
Sertoli-Leydig cell tumor of the ovary: a case report with endocrinologic observations. (15251509)
1996
28
Ovarian serous cystadenoma associated with Sertoli-Leydig cell tumor--a case report. (8703377)
1996
29
Ovarian Sertoli-Leydig cell tumor with retiform pattern. (8771159)
1995
30
Late presentation of an alpha-fetoprotein secreting isolated large upper abdominal retroperitoneal Sertoli-Leydig cell tumor recurrence. (7534742)
1995
31
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
32
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
33
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
34
An ovarian Sertoli-Leydig cell tumor with heterologous mucinous gland and NSE-immunoreactive-cell. (2457358)
1988
35
Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor. (2844882)
1988
36
Raised serum alpha-fetoprotein in Sertoli-Leydig cell tumor (androblastoma) of ovary: report of two cases. (2437064)
1987
37
Ovarian Sertoli-Leydig cell tumor (androblastoma) with retiform pattern. A clinicopathologic study. (3677027)
1987
38
Bilateral Sertoli-Leydig cell tumor with heterologous elements: report of an unusual case and review of the literature. (3732587)
1986
39
Demonstration of hydroxysteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study. (2984872)
1985
40
Steroid biosynthesis in the Sertoli-Leydig cell tumor tissue of the human ovary; enzymhistochemical and immunohistochemical studies. (6425925)
1984
41
Steroid metabolism in an androblastoma (Sertoli-Leydig cell tumor): a histopathological and biochemical study. (6327547)
1984
42
A Sertoli-Leydig cell tumor and pregnancy. Clinical, endocrine, radiologic, and electron microscopic findings. (6660923)
1983
43
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
44
Sertoli-Leydig cell tumor of the ovary with teratomatous differentiation: clinicopathologic considerations. (7104958)
1982
45
Ovarian Sertoli-Leydig cell tumor with rhabdomyosarcoma: an ultrastructural study. (7157497)
1982
46
Light and electron microscopic study of an intermediate sertoli-leydig cell tumor with a review of literatures in Japan. (1026031)
1976
47
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
48
Ultrastructure of a human chorionic gonadotropin-and adrenocorticotropin-responsive functioning Sertoli-Leydig cell tumor (type I). (4353887)
1973
49
Ultrastructure of an intermediate Sertoli-Leydig cell tumor. A histogenetic misnomer. (4311418)
1969
50
Ultrastructure of ovarian stromal cell tumors. Sertoli-Leydig cell tumor and lipid cell tumor. (5681434)
1968

Variations for Sertoli-Leydig Cell Tumor

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Expression for genes affiliated with Sertoli-Leydig Cell Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sertoli-Leydig Cell Tumor

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Pathways for genes affiliated with Sertoli-Leydig Cell Tumor

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5PGR, INHA

Compounds for genes affiliated with Sertoli-Leydig Cell Tumor

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45Novoseek, 29IUPHAR, 11DrugBank, 3BitterDB, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
13beta-hydroxysteroid459.9PGR, INHA
2clomiphene citrate459.8AFP, PGR
3spec-t459.8AFP, PGR
4diethylstilbestrol45 29 1111.8AFP, PGR
5acetaminophen45 3 51 24 1113.8AFP, PGR
6hematoxylin459.7INHA, MUC1
7estrone45 29 24 1112.7PGR, AFP
8trastuzumab45 51 1111.7MUC1, PGR
9progestin459.7MUC1, PGR
10polyethylene glycol459.6MUC1, AFP
11biotin45 24 1111.6MUC1, INHA
12galactose459.6AFP, MUC1
13gold459.5AFP, MUC1
14sialic acid459.4MUC1, AFP
15cyclophosphamide45 51 1111.4PGR, AFP
16cytosine45 2410.4AFP, WT1
17agarose459.4INHA, MUC1
18dihydrotestosterone45 29 24 1112.4MUC1, PGR
19vincristine45 51 1111.4WT1, AFP
20thyroxine45 2410.3AFP, PGR
21mifepristone45 29 61 1112.2MUC1, PGR, AFP
22adriamycin459.2AFP, MUC1, PGR
23folate459.2PGR, AFP, MUC1
24dmso459.2AFP, PGR, MUC1
25methotrexate51 45 1111.2MUC1, PGR, AFP
265fluorouracil459.2MUC1, AFP, PGR
27agar459.2AFP, MUC1, PGR
28alanine459.2AFP, PGR, INHA
29dexamethasone45 51 29 1112.1MUC1, PGR, AFP
30doxorubicin45 51 1111.0WT1, PGR, AFP
31glutamine459.0WT1, AFP, PGR
32oligonucleotide459.0WT1, INHA, AFP
33forskolin45 51 1111.0INHA, MUC1, WT1
34b 723459.0WT1, MUC1, AFP
35chloramphenicol45 3 51 1111.9WT1, MUC1, AFP
36butyrate458.9AFP, WT1, MUC1
37thymidine45 249.9AFP, WT1, MUC1
38creatinine458.9MUC1, AFP, WT1
39estradiol45 24 1110.8MUC1, INHA, PGR, AFP
40hyaluronic acid45 249.7WT1, MUC1
41threonine458.7MUC1, WT1, AFP
42steroid458.6AFP, INHA, PGR, WT1
43ribonucleic acid458.5PGR, MUC1, WT1, INHA
44vegf458.4MUC1, PGR, AFP, WT1
45retinoic acid45 249.4MUC1, PGR, AFP, WT1
46tyrosine458.4INHA, MUC1, WT1, AFP
47paraffin458.0AFP, WT1, MUC1, PGR, INHA
48progesterone45 29 61 24 1112.0PGR, MUC1, AFP, INHA, WT1
49testosterone45 61 24 1111.0AFP, PGR, INHA, MUC1, WT1
50estrogen458.0WT1, PGR, AFP, INHA, MUC1

GO Terms for genes affiliated with Sertoli-Leydig Cell Tumor

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16Gene Ontology
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Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ovulation from ovarian follicleGO:0015429.3PGR, AFP
2regulation of cell cycleGO:0517269.3DICER1, INHA
3male gonad developmentGO:0085849.2WT1, INHA

Products for genes affiliated with Sertoli-Leydig Cell Tumor

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25ICD10
26ICD10 via Orphanet
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