MCID: SRT003
MIFTS: 36

Sertoli-Leydig Cell Tumor malady

Categories: Rare diseases, Cancer diseases, Reproductive diseases

Aliases & Classifications for Sertoli-Leydig Cell Tumor

Aliases & Descriptions for Sertoli-Leydig Cell Tumor:

Name: Sertoli-Leydig Cell Tumor 12 52 42 14 69
Sertoli-Leydig Cell Tumor of Intermediate Differentiation 69
Sertoli-Leydig Cell Tumor of the Ovary 50
Sertoli-Leydig Cell Tumor of Ovary 69
Sertoli-Leydig Cell Tumors 50
Arrhenoblastoma of Ovary 50
Androblastoma of Ovary 50
Arrhenoblastoma 50

Classifications:



External Ids:

Disease Ontology 12 DOID:2997
MeSH 42 D018310
SNOMED-CT 64 34110004
UMLS 69 C0206723

Summaries for Sertoli-Leydig Cell Tumor

NIH Rare Diseases : 50 sertoli-leydig cell tumors are a cancer that starts in the female ovaries. the cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. this type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. while they can be found in women of all age groups, they are most common in young women. treatment involves surgery and chemotherapy or radiation if the cancer has spread. because sertoli-leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good. last updated: 3/25/2010

MalaCards based summary : Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of intermediate differentiation, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and malignant sertoli-leydig cell tumor of ovary, and has symptoms including hoarseness An important gene associated with Sertoli-Leydig Cell Tumor is AFP (Alpha Fetoprotein). The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and testes, and related phenotype is behavior/neurological.

Related Diseases for Sertoli-Leydig Cell Tumor

Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
id Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.6
2 malignant sertoli-leydig cell tumor of ovary 12.3
3 malignant sertoli-leydig cell tumor 12.2
4 leydig cell tumor 11.0
5 androgen insensitivity 10.3
6 handigodu disease 10.3 CALB2 DICER1
7 complete androgen insensitivity syndrome 10.2
8 vulvar benign neoplasm 10.2 DICER1 SYP
9 sphenoid sinus squamous cell carcinoma 10.2 AFP CALB2
10 liver angiosarcoma 10.2 DICER1 PGR
11 persian gulf syndrome 10.2 AFP CALB2
12 bone deterioration disease 10.2 DICER1 SYP
13 goiter 10.2
14 cervicitis 10.2
15 cystadenoma 10.2
16 multinodular goiter 10.2
17 rhabdomyosarcoma 10.2
18 sarcoma 10.2
19 exudative glomerulonephritis 10.2 DICER1 SYP
20 cranial nerve disease 10.2 AFP CALB2
21 duodenal obstruction 10.2 DICER1 SYP
22 mhc class ii deficiency 10.2 AFP PGR
23 infiltrating renal pelvis transitional cell carcinoma 10.2 AFP SYP
24 breast mucoepidermoid carcinoma 10.2 CALB2 SYP
25 hunter macpherson syndrome 10.2 CALB2 SYP
26 pleural lipoma 10.2 CALB2 PGR
27 ovarian germ cell teratoma 10.2 AFP SYP
28 kidney disease 10.2 AFP SYP
29 rectum leiomyoma 10.2 AFP SYP
30 adult botryoid rhabdomyosarcoma 10.2 AFP SYP
31 thymic dysplasia 10.2 CALB2 MUC1
32 hidrocystoma 10.2 CALB2 SYP
33 medullomyoblastoma 10.1 AFP SYP
34 wheat allergy 10.1 PGR SYP
35 pancreatic colloid cystadenoma 10.1 PGR SYP
36 lymphangiosarcoma 10.1 CALB2 MUC1
37 main bronchus cancer 10.1 PGR SYP
38 testicular trophoblastic tumor 10.1 AFP SYP
39 placental insufficiency 10.1 CALB2 SYP
40 paraphimosis 10.1 PGR SYP
41 myotonic disease 10.1 CALB2 SYP
42 chondroblastoma 10.1 CALB2 MUC1
43 lethal congenital contracture syndrome 10.1 AFP MUC1
44 vulvar alveolar soft part sarcoma 10.1 PGR SYP
45 lacrimal gland mucoepidermoid carcinoma 10.1 MUC1 PGR
46 skeletal-extraskeletal angiomatosis 10.1 MUC1 SYP
47 cervical lymphoepithelioma-like carcinoma 10.1 MUC1 PGR
48 prolactin producing pituitary tumor 10.1 MUC1 SYP
49 exotropia 10.1 MUC1 PGR
50 marfanoid hypermobility syndrome 10.1 MUC1 PGR

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to Sertoli-Leydig Cell Tumor

Symptoms & Phenotypes for Sertoli-Leydig Cell Tumor

UMLS symptoms related to Sertoli-Leydig Cell Tumor:


hoarseness

MGI Mouse Phenotypes related to Sertoli-Leydig Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 AFP CALB2 DICER1 INSL3 PGR SYP

Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

Drugs for Sertoli-Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Succinylcholine Approved Phase 2 306-40-1 5314
6
Bleomycin Approved Phase 2 11056-06-7 5360373
7
Bevacizumab Approved, Investigational Phase 2 216974-75-3
8 Albumin-Bound Paclitaxel Phase 2
9 Antimitotic Agents Phase 2
10 Antineoplastic Agents, Phytogenic Phase 2
11 Neuromuscular Agents Phase 2
12 Neuromuscular Blocking Agents Phase 2
13 Neuromuscular Depolarizing Agents Phase 2
14 Topoisomerase Inhibitors Phase 2
15 Peripheral Nervous System Agents Phase 2
16 Anti-Bacterial Agents Phase 2
17 Etoposide phosphate Phase 2
18 Antibiotics, Antitubercular Phase 2
19 Mitogens Phase 2
20 Angiogenesis Inhibitors Phase 2
21 Angiogenesis Modulating Agents Phase 2
22 Endothelial Growth Factors Phase 2
23 Immunoglobulin G Phase 2
24 Immunoglobulins Phase 2
25 Antibodies, Monoclonal Phase 2
26 Antibodies Phase 2
27
Gemcitabine Approved Phase 1 95058-81-4 60750
28 Anti-Infective Agents Phase 1
29 Immunosuppressive Agents Phase 1
30 Antimetabolites Phase 1
31 Antimetabolites, Antineoplastic Phase 1
32 Antiviral Agents Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
4 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1
5 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
6 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903

Search NIH Clinical Center for Sertoli-Leydig Cell Tumor

Cochrane evidence based reviews: sertoli-leydig cell tumor

Genetic Tests for Sertoli-Leydig Cell Tumor

Anatomical Context for Sertoli-Leydig Cell Tumor

MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

39
Ovary, Testis, Testes, Breast, Thyroid, Skeletal Muscle, Uterus

Publications for Sertoli-Leydig Cell Tumor

Articles related to Sertoli-Leydig Cell Tumor:

(show top 50) (show all 133)
id Title Authors Year
1
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
2
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
3
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
4
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
5
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
6
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
7
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
8
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
9
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
10
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. ( 26408257 )
2015
11
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
12
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
13
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. ( 25926909 )
2014
14
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. ( 25032133 )
2014
15
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. ( 24783104 )
2014
16
A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report. ( 24708902 )
2014
17
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. ( 25299229 )
2014
18
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. ( 25002956 )
2014
19
Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. ( 24696734 )
2014
20
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review. ( 25296983 )
2014
21
Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. ( 25027813 )
2014
22
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database. ( 22691037 )
2013
23
Poorly differentiated ovarian sertoli-leydig cell tumor in a 16-year-old single woman: a case report and literature review. ( 23878752 )
2013
24
Ovarian Sertoli-Leydig cell tumor: a report of seven cases and a review of the literature. ( 23173550 )
2013
25
Fine needle aspiration cytology of Sertoli-Leydig cell tumors of ovary masquerading as dysgerminoma. ( 22102529 )
2013
26
Complete Androgen Insensitivity Syndrome with a Sertoli-Leydig Cell Tumor. ( 24333107 )
2013
27
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. ( 24328002 )
2013
28
Sertoli-Leydig cell tumor presenting hyperestrogenism in a postmenopausal woman: a case report and review of the literature. ( 23276568 )
2012
29
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. ( 21847587 )
2012
30
Ovarian Sertoli-Leydig cell tumor in a 9-month-old infant with special histologic pattern. ( 22443217 )
2012
31
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. ( 22635079 )
2012
32
Successful term pregnancies after laparoscopic excision of poorly differentiated Sertoli-Leydig cell tumor of the ovary. ( 22808364 )
2012
33
First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease. ( 22633001 )
2012
34
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. ( 23084689 )
2012
35
Cytologic, immunocytologic, histopathologic and immunohistologic diagnosis of the poorly differentiated sertoli-leydig cell tumor. ( 21791911 )
2011
36
The case reported as bilateral Sertoli-Leydig cell tumors in a 61-year-old woman with uterine aplasia may instead represent complete androgen insensitivity syndrome. ( 21623193 )
2011
37
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. ( 21205968 )
2011
38
Retiform Sertoli-Leydig cell tumor of ovary in a 9-year-old girl: case report and review of the literature. ( 21347632 )
2011
39
Management of metastatic ovarian Sertoli-Leydig cell tumor with sporadic multinodular goiter: a case report and literature review. ( 21919698 )
2011
40
7,12-dimethylbenz[a]anthracene induces sertoli-leydig-cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclohexene diepoxide. ( 20158943 )
2010
41
Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. ( 19957213 )
2010
42
Postpartum hemorrhage from ruptured Sertoli-Leydig cell tumor: a case report. ( 21043371 )
2010
43
Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements. ( 20407320 )
2010
44
Mucinous adenocarcinoma as heterologous element in intermediately differentiated Sertoli-Leydig cell tumor of the ovary. ( 19674851 )
2010
45
Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case report. ( 20736765 )
2010
46
Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. ( 19136796 )
2009
47
Recurrent alpha-fetoprotein secreting Sertoli-Leydig cell tumor of ovary with an unusual presentation. ( 19282570 )
2009
48
Metastatic rhabdomyosarcomatous elements, mimicking a primary sarcoma, in the omentum, from a poorly differentiated ovarian Sertoli-Leydig cell tumor in a young girl: an unusual presentation with a literature review. ( 19805972 )
2009
49
Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokeratin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor. ( 19851210 )
2009
50
Retiform pattern of Sertoli-Leydig cell tumor of the ovary in a 4-year-old girl. ( 19215568 )
2009

Variations for Sertoli-Leydig Cell Tumor

Expression for Sertoli-Leydig Cell Tumor

Search GEO for disease gene expression data for Sertoli-Leydig Cell Tumor.

Pathways for Sertoli-Leydig Cell Tumor

GO Terms for Sertoli-Leydig Cell Tumor

Cellular components related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 8.62 CALB2 SYP

Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ovulation from ovarian follicle GO:0001542 8.62 AFP PGR

Sources for Sertoli-Leydig Cell Tumor

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