MCID: SRT003
MIFTS: 36

Sertoli-Leydig Cell Tumor malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Sertoli-Leydig Cell Tumor

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Aliases & Descriptions for Sertoli-Leydig Cell Tumor:

Name: Sertoli-Leydig Cell Tumor 10 47 12 65 36
Sertoli-Leydig Cell Tumor of Intermediate Differentiation 65
Sertoli-Leydig Cell Tumor of the Ovary 45
Sertoli-Leydig Cell Tumor of Ovary 65
 
Sertoli-Leydig Cell Tumors 45
Arrhenoblastoma of Ovary 45
Androblastoma of Ovary 45
Arrhenoblastoma 45


Classifications:



External Ids:

Disease Ontology10 DOID:2997
SNOMED-CT59 34110004
MeSH36 D018310

Summaries for Sertoli-Leydig Cell Tumor

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NIH Rare Diseases:45 Sertoli-leydig cell tumors are a cancer that starts in the female ovaries. the cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. this type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. while they can be found in women of all age groups, they are most common in young women. treatment involves surgery and chemotherapy or radiation if the cancer has spread. because sertoli-leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good. last updated: 3/25/2010

MalaCards based summary: Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of intermediate differentiation, is related to adenoma and leydig cell tumor. An important gene associated with Sertoli-Leydig Cell Tumor is AFP (Alpha-Fetoprotein), and among its related pathways is Ovarian Infertility Genes. Affiliated tissues include ovary, testis and testes, and related mouse phenotypes are tumorigenesis and normal.

Related Diseases for Sertoli-Leydig Cell Tumor

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Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.5CALB2, INHA, MUC1
2leydig cell tumor11.4
3goiter, multinodular 1, with or without sertoli-leydig cell tumors10.8
4malignant sertoli-leydig cell tumor of ovary10.7
5androgen insensitivity10.7
6complete androgen insensitivity syndrome10.7
7malignant sertoli-leydig cell tumor10.6
8multinodular goiter10.6
9cystadenoma10.6
10cervicitis10.6
11goiter10.6
12rhabdomyosarcoma10.6
13sarcoma10.6
14amenorrhea10.5
15hyperandrogenism10.5
16adenocarcinoma10.5
17hematopoietic stem cell transplantation10.4
18rete testis adenocarcinoma10.4
19mucinous adenocarcinoma10.4
20endemic goiter10.4
21adrenal adenoma10.4
22breast adenoma10.4
23cystic teratoma10.4
24embryonal rhabdomyosarcoma10.4
25vaginitis10.4
26desmoplastic small round cell tumor10.4
27granulosa cell tumor of the ovary10.4
28gynandroblastoma10.4
29precocious puberty10.4
30familial multinodular goiter10.4
31teratoma10.4
32hole retinal cyst10.2AFP, CALB2
33retinal artery occlusion10.2AFP, CALB2
34proctitis10.2AFP, PGR
35testicular malignant germ cell cancer10.2AFP, WT1
36vulvar keratinizing squamous cell carcinoma10.2AFP, WT1
37mixed epithelial tumor of ovary10.2AFP, PGR
38kidney lipoma10.2CALB2, PGR
39ovary neuroendocrine neoplasm10.2CALB2, WT1
40fallopian tube disease10.2CALB2, WT1
41congenital nonhemolytic jaundice10.2AFP, WT1
42ceruminous carcinoma10.2AFP, MUC1
43clear cell ependymoma10.2AFP, MUC1
44histiocytoid hemangioma10.2CALB2, WT1
45peritonitis10.2CALB2, WT1
46microcystic meningioma10.2CALB2, MUC1
47splenic artery aneurysm10.2MUC1, PGR
48malignant cystic nephroma10.2MUC1, PGR
49acute frontal sinusitis10.1CALB2, WT1
50carney complex-trismus-pseudocamptodactyly syndrome10.1CALB2, MUC1

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to sertoli-leydig cell tumor

Symptoms for Sertoli-Leydig Cell Tumor

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Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

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Drugs for Sertoli-Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
GemcitabineapprovedPhase 1180095058-81-460750
Synonyms:
103882-84-4
122111-03-9
2',2'-DiF-dC
2',2'-Difluoro-2'-deoxycytidine
2',2'-Difluorodeoxycytidine
2'-Deoxy-.beta.-D-2',2'-difluorocytidine
2'-Deoxy-2',2'-difluorocytidine
4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one
4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
95058-81-4
AB1004842
AC1L1TUQ
C07650
CCRIS 8984
CHEBI:175901
CHEMBL888
CID60750
Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine
D02368
DB00441
DDFC
DFDC
DFdC
DFdCyd
Folfugem
GEO
Gamcitabine
GemLip
Gemcel
 
Gemcin
Gemcitabin
Gemcitabina
Gemcitabina [INN-Spanish]
Gemcitabine
Gemcitabine (USAN/INN)
Gemcitabine HCl
Gemcitabine Hydrochloride
Gemcitabine hydrochloride
Gemcitabine stereoisomer
Gemcitabinum
Gemcitabinum [INN-Latin]
Gemtro
Gemzar
Gemzar (hydrochloride)
HMS2089P10
HSDB 7567
Inno-D07001
LS-59139
LY 188011
LY-188011
LY188011
NCGC00168784-01
NChemBio.2007.10-comp25
NSC 613327
NSC613327
TL8005979
UNII-B76N6SBZ8R
ZINC18279854
Zefei
gemcitabine
nchembio.573-comp7
nchembio.90-comp2
2
CarboplatinapprovedPhase 1181241575-94-410339178, 498142, 38904, 38904, 498142
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)

Interventional clinical trials:

idNameStatusNCT IDPhase
1Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological CancerCompletedNCT01652794Phase 1
2Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast CancerCompletedNCT01764789
3DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History StudyRecruitingNCT01247597
4Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer SyndromeRecruitingNCT00565903
5Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal TumorsActive, not recruitingNCT01572467

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Cochrane evidence based reviews: Sertoli-Leydig Cell Tumor

Genetic Tests for Sertoli-Leydig Cell Tumor

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Anatomical Context for Sertoli-Leydig Cell Tumor

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MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

33
Ovary, Testis, Testes, Skeletal muscle, Breast

Animal Models for Sertoli-Leydig Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Sertoli-Leydig Cell Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5AFP, INHA, MUC1, PGR
2MP:00028738.0CALB2, INHA, MUC1, PGR, WT1
3MP:00053897.4AFP, INHA, INSL3, PGR, WT1
4MP:00053797.3AFP, INHA, INSL3, MUC1, PGR, WT1

Publications for Sertoli-Leydig Cell Tumor

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Articles related to Sertoli-Leydig Cell Tumor:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. (25002956)
2014
2
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. (25032133)
2014
3
Ovarian Sertoli-Leydig cell tumor with heterologous elements of gastrointestinal type associated with elevated serum alpha-fetoprotein level: an unusual case and literature review. (25926909)
2014
4
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. (25299229)
2014
5
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. (24783104)
2014
6
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. (24328002)
2013
7
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
8
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
9
First case of ovarian Sertoli-Leydig cell tumor after an allogeneic hematopoietic stem cell transplantation for Hodgkin's disease. (22633001)
2012
10
Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case report. (20736765)
2010
11
Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements. (20407320)
2010
12
Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. (19289327)
2009
13
Recurrent alpha-fetoprotein secreting Sertoli-Leydig cell tumor of ovary with an unusual presentation. (19282570)
2009
14
Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. (19136796)
2009
15
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
16
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
17
Immunohistochemical and ultrastructural analysis of a poorly differentiated pediatric age Sertoli-Leydig cell tumor. (17022971)
2007
18
Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. (17177833)
2006
19
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
20
Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors. (16175078)
2005
21
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
22
Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study. (14734221)
2004
23
Ovarian Sertoli-Leydig cell tumor, endometrioid-like yolk sac tumor, and Y-chromosomal material. (12759534)
2003
24
Sertoli Leydig cell tumor with heterologous gastrointestinal epithelium: a case report. (15027740)
2003
25
Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. (11788622)
2002
26
Ossifying well-differentiated Sertoli-Leydig cell tumor of the ovary. (10684379)
2000
27
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
28
Sertoli-Leydig cell tumor of the ovary: a case report with endocrinologic observations. (15251509)
1996
29
Ovarian serous cystadenoma associated with Sertoli-Leydig cell tumor--a case report. (8703377)
1996
30
Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)
1995
31
Ovarian Sertoli-Leydig cell tumor with retiform pattern. (8771159)
1995
32
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
33
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
34
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
35
An ovarian Sertoli-Leydig cell tumor with heterologous mucinous gland and NSE-immunoreactive-cell. (2457358)
1988
36
Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor. (2844882)
1988
37
Raised serum alpha-fetoprotein in Sertoli-Leydig cell tumor (androblastoma) of ovary: report of two cases. (2437064)
1987
38
Ovarian Sertoli-Leydig cell tumor (androblastoma) with retiform pattern. A clinicopathologic study. (3677027)
1987
39
Bilateral Sertoli-Leydig cell tumor with heterologous elements: report of an unusual case and review of the literature. (3732587)
1986
40
Demonstration of hydroxysteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study. (2984872)
1985
41
Steroid biosynthesis in the Sertoli-Leydig cell tumor tissue of the human ovary; enzymhistochemical and immunohistochemical studies. (6425925)
1984
42
Steroid metabolism in an androblastoma (Sertoli-Leydig cell tumor): a histopathological and biochemical study. (6327547)
1984
43
A Sertoli-Leydig cell tumor and pregnancy. Clinical, endocrine, radiologic, and electron microscopic findings. (6660923)
1983
44
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
45
Sertoli-Leydig cell tumor of the ovary with teratomatous differentiation: clinicopathologic considerations. (7104958)
1982
46
Ovarian Sertoli-Leydig cell tumor with rhabdomyosarcoma: an ultrastructural study. (7157497)
1982
47
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
48
Ultrastructure of a human chorionic gonadotropin-and adrenocorticotropin-responsive functioning Sertoli-Leydig cell tumor (type I). (4353887)
1973
49
Ultrastructure of an intermediate Sertoli-Leydig cell tumor. A histogenetic misnomer. (4311418)
1969
50
Ultrastructure of ovarian stromal cell tumors. Sertoli-Leydig cell tumor and lipid cell tumor. (5681434)
1968

Variations for Sertoli-Leydig Cell Tumor

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Expression for genes affiliated with Sertoli-Leydig Cell Tumor

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Search GEO for disease gene expression data for Sertoli-Leydig Cell Tumor.

Pathways for genes affiliated with Sertoli-Leydig Cell Tumor

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Pathways related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4INHA, PGR

GO Terms for genes affiliated with Sertoli-Leydig Cell Tumor

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Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ovulation from ovarian follicleGO:000154210.2AFP, PGR
2SMAD protein signal transductionGO:00603959.7AFP, INHA
3epithelial cell differentiationGO:00308559.2MUC1, WT1
4cell-cell signalingGO:00072678.5INHA, INSL3, PGR
5male gonad developmentGO:00085848.5INHA, INSL3, WT1

Molecular functions related to Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051028.6INHA, INSL3, PGR

Sources for Sertoli-Leydig Cell Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet