MCID: SRT003
MIFTS: 49

Sertoli-Leydig Cell Tumor malady

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Summaries for Sertoli-Leydig Cell Tumor

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NIH Rare Diseases:42 Sertoli-leydig cell tumors are a cancer that starts in the female ovaries. the cancer cells produce and release a male sex hormone which may cause the development of male physical characteristics (virilization), including facial hair and a deep voice. this type of tumor is sometimes called arrhenoblastoma of the ovary or a stromal tumor. sertoli-leydig cell tumors are rare tumors which account for less than 0.5% of all ovarian tumors. while they can be found in women of all age groups, they are most common in young women. treatment involves surgery and chemotherapy or radiation if the cancer has spread. because sertoli-leydig cell tumors have a low chance of spreading, if the tumor is found early, chances for survival are good. last updated: 3/25/2010

MalaCards based summary: Sertoli-Leydig Cell Tumor, also known as sertoli-leydig cell tumor of the ovary, is related to leydig cell tumor and cystadenoma. An important gene associated with Sertoli-Leydig Cell Tumor is DICER1 (dicer 1, ribonuclease type III), and among its related pathways is Ovarian Infertility Genes. The compounds 3beta-hydroxysteroid and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and skeletal muscle, and related mouse phenotypes are immune system and liver/biliary system.

Wikipedia:65 Sertoli?Leydig cell tumour is a group of tumours composed of variable proportions of Sertoli cells,... more...

Aliases & Classifications for Sertoli-Leydig Cell Tumor

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Sertoli-Leydig Cell Tumor, Aliases & Descriptions:

Name: Sertoli-Leydig Cell Tumor 8 10 44 62
Sertoli-Leydig Cell Tumor of the Ovary 42 62
Sertoli-Leydig Cell Tumors 42 62
 
Androblastoma of Ovary 42 62
Arrhenoblastoma of Ovary 42
Arrhenoblastoma 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


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Disease Ontology8 DOID:2997
SNOMED-CT57 34110004
MeSH34 D018310

Related Diseases for Sertoli-Leydig Cell Tumor

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Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1leydig cell tumor32.8INHA
2cystadenoma31.5INHA
3rhabdomyosarcoma30.6INHA, WT1
4cystadenocarcinoma30.6MUC1
5desmoplastic small round cell tumor30.5WT1, MUC1
6dysgerminoma30.3INHA, AFP, WT1
7adenocarcinoma29.8INHA, AFP, PGR, MUC1, WT1
8androgen insensitivity syndrome10.7
9complete androgen insensitivity syndrome10.6
10multinodular goiter10.6
11goiter10.6
12sarcoma10.6
13goiter, multinodular 1, with or without sertoli-leydig cell tumors10.6
14malignant sertoli-leydig cell tumor of ovary10.6
15amenorrhea10.5
16hyperandrogenism10.5
17malignant sertoli-leydig cell tumor10.5
18adenoma10.5
19cervicitis10.5
20cystic nephroma10.5DICER1
21adenofibroma10.4INHA
22adenosarcoma10.4PGR
23secretory meningioma10.4MUC1
24hematopoietic stem cell transplantation10.3
25rete testis adenocarcinoma10.3
26mucinous adenocarcinoma10.3
27adrenal adenoma10.3
28breast adenoma10.3
29cystic teratoma10.3
30vaginitis10.3
31granulosa cell tumor of the ovary10.3
32gynandroblastoma10.3
33precocious puberty10.3
34teratoma10.3
35metanephric adenoma10.3WT1
36hemihypertrophy10.3WT1
37adenomatoid tumor10.3WT1
38germinoma10.2INHA, AFP
39endodermal sinus tumor10.2INHA, AFP
40endometrial stromal sarcoma10.2INHA, PGR
41gynecomastia10.2PGR, INHA
42testicular cancer10.2AFP, INHA
43mammary paget's disease10.2MUC1, PGR
44spindle cell carcinoma10.1MUC1, PGR
45hemangioblastoma10.1MUC1, INHA
46chordoma10.1INHA, MUC1
47primary hyperoxaluria10.1WT1
48seminoma10.1AFP, INHA
49renal clear cell carcinoma10.1INHA, MUC1
50neurilemmoma10.1INHA, MUC1

Graphical network of the top 20 diseases related to Sertoli-Leydig Cell Tumor:



Diseases related to sertoli-leydig cell tumor

Symptoms for Sertoli-Leydig Cell Tumor

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Drugs & Therapeutics for Sertoli-Leydig Cell Tumor

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Drug clinical trials:

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Genetic Tests for Sertoli-Leydig Cell Tumor

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Anatomical Context for Sertoli-Leydig Cell Tumor

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MalaCards organs/tissues related to Sertoli-Leydig Cell Tumor:

32
Ovary, Testis, Skeletal muscle, Breast, Testes

Animal Models for Sertoli-Leydig Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Sertoli-Leydig Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.3WT1, DICER1, PGR, INHA
2MP:00053708.2WT1, DICER1, MUC1, INHA
3MP:00053858.2INHA, PGR, DICER1, WT1
4MP:00020068.1INHA, AFP, PGR, MUC1, DICER1
5MP:00053978.0INHA, PGR, DICER1, WT1
6MP:00053897.9INHA, AFP, PGR, DICER1, WT1
7MP:00028737.8INHA, PGR, MUC1, DICER1, WT1
8MP:00107687.7INHA, AFP, PGR, DICER1, WT1
9MP:00053797.3WT1, DICER1, MUC1, PGR, AFP, INHA
10MP:00053767.3INHA, AFP, PGR, MUC1, DICER1, WT1

Publications for Sertoli-Leydig Cell Tumor

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Articles related to Sertoli-Leydig Cell Tumor:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Bilateral sertoli-leydig cell tumor in a primigravida: a rare case. (25002956)
2014
2
Bilateral laparoscopic gonadectomy in a patient with complete androgen insensitivity syndrome and bilateral sertoli-leydig cell tumor: a case report and brief review of the literature. (25032133)
2014
3
Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism. (25299229)
2014
4
Sertoli-leydig cell tumor of ovary- a diagnostic dilemma. (24783104)
2014
5
A case of successful salvage chemotherapy of recurrent ovarian sertoli-leydig cell tumor. (24328002)
2013
6
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. (21847587)
2012
7
Malignant ovarian Sertoli-Leydig cell tumor localized with selective ovarian vein sampling. (23084689)
2012
8
Sertoli-Leydig cell tumor of the ovary--morphological and immunohistochemical analysis. (22635079)
2012
9
Bilateral ovarian well-differentiated Sertoli-Leydig cell tumors with heterologous elements associated with unilateral serous cystadenoma--a case report. (20736765)
2010
10
Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements. (20407320)
2010
11
Incidental detection of Sertoli-Leydig cell tumor by FDG PET/CT imaging in a patient with androgen insensitivity syndrome. (19957213)
2010
12
Hyperandrogenism due to a testosterone-secreting Sertoli-Leydig cell tumor associated with a dehydroepiandrosterone sulfate-secreting adrenal adenoma in a postmenopausal woman: case presentation and review of literature. (19289327)
2009
13
Recurrent alpha-fetoprotein secreting Sertoli-Leydig cell tumor of ovary with an unusual presentation. (19282570)
2009
14
Bilateral Sertoli-Leydig cell tumor of the ovary: a rare case report. (19136796)
2009
15
Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. (17885486)
2007
16
A rare ovarian tumor - Sertoli-Leydig cell tumor with heterologous element. (18311394)
2007
17
Immunohistochemical and ultrastructural analysis of a poorly differentiated pediatric age Sertoli-Leydig cell tumor. (17022971)
2007
18
Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. (17177833)
2006
19
Sertoli-Leydig cell tumor of ovary with heterologous element: a case report. (16366107)
2005
20
Uterine retiform sertoli-leydig cell tumor: report of a case providing additional evidence that uterine tumors resembling ovarian sex cord tumors have a histologic and immunohistochemical phenotype of genuine sex cord tumors. (16175078)
2005
21
Sertoli-Leydig cell tumor of the ovary. (15216408)
2004
22
Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study. (14734221)
2004
23
Ovarian Sertoli-Leydig cell tumor, endometrioid-like yolk sac tumor, and Y-chromosomal material. (12759534)
2003
24
Sertoli Leydig cell tumor with heterologous gastrointestinal epithelium: a case report. (15027740)
2003
25
Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. (11788622)
2002
26
Ossifying well-differentiated Sertoli-Leydig cell tumor of the ovary. (10684379)
2000
27
Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. (9314929)
1997
28
Sertoli-Leydig cell tumor of the ovary: a case report with endocrinologic observations. (15251509)
1996
29
Ovarian serous cystadenoma associated with Sertoli-Leydig cell tumor--a case report. (8703377)
1996
30
Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. (9420846)
1995
31
Ovarian Sertoli-Leydig cell tumor with retiform pattern. (8771159)
1995
32
Diagnosis and resection of an oral contraceptive-suppressible Sertoli-Leydig cell tumor with preservation of fertility and a 7-year follow-up. (2523030)
1989
33
Sertoli-Leydig cell tumor associated with a mature cystic teratoma in a single ovary. (2587573)
1989
34
Ovarian Sertoli-Leydig cell tumor with elevated serum alpha-fetoprotein. (2467733)
1989
35
An ovarian Sertoli-Leydig cell tumor with heterologous mucinous gland and NSE-immunoreactive-cell. (2457358)
1988
36
Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor. (2844882)
1988
37
Raised serum alpha-fetoprotein in Sertoli-Leydig cell tumor (androblastoma) of ovary: report of two cases. (2437064)
1987
38
Ovarian Sertoli-Leydig cell tumor (androblastoma) with retiform pattern. A clinicopathologic study. (3677027)
1987
39
Bilateral Sertoli-Leydig cell tumor with heterologous elements: report of an unusual case and review of the literature. (3732587)
1986
40
Demonstration of hydroxysteroid dehydrogenases and testosterone in the Sertoli-Leydig cell tumor (androblastoma) tissue of the human ovary: an enzyme histochemical and immunohistochemical study. (2984872)
1985
41
Steroid biosynthesis in the Sertoli-Leydig cell tumor tissue of the human ovary; enzymhistochemical and immunohistochemical studies. (6425925)
1984
42
Steroid metabolism in an androblastoma (Sertoli-Leydig cell tumor): a histopathological and biochemical study. (6327547)
1984
43
A Sertoli-Leydig cell tumor and pregnancy. Clinical, endocrine, radiologic, and electron microscopic findings. (6660923)
1983
44
Metastatic Sertoli-Leydig cell tumor of the ovary during pregnancy treated by BV-CAP chemotherapy. (6177244)
1982
45
Sertoli-Leydig cell tumor of the ovary with teratomatous differentiation: clinicopathologic considerations. (7104958)
1982
46
Ovarian Sertoli-Leydig cell tumor with rhabdomyosarcoma: an ultrastructural study. (7157497)
1982
47
Sertoli-Leydig cell tumor of the ovary, with an associated mucinous cystadenoma. An ultrastructural and endocrine study. (4280005)
1974
48
Ultrastructure of a human chorionic gonadotropin-and adrenocorticotropin-responsive functioning Sertoli-Leydig cell tumor (type I). (4353887)
1973
49
Ultrastructure of an intermediate Sertoli-Leydig cell tumor. A histogenetic misnomer. (4311418)
1969
50
Ultrastructure of ovarian stromal cell tumors. Sertoli-Leydig cell tumor and lipid cell tumor. (5681434)
1968

Variations for Sertoli-Leydig Cell Tumor

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Expression for genes affiliated with Sertoli-Leydig Cell Tumor

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Expression patterns in normal tissues for genes affiliated with Sertoli-Leydig Cell Tumor

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Pathways for genes affiliated with Sertoli-Leydig Cell Tumor

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Pathways related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5PGR, INHA

Compounds for genes affiliated with Sertoli-Leydig Cell Tumor

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Compounds related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
13beta-hydroxysteroid449.9PGR, INHA
2clomiphene citrate449.8PGR, AFP
3spec-t449.8PGR, AFP
4diethylstilbestrol44 28 1111.8PGR, AFP
5acetaminophen44 2 50 24 1113.8PGR, AFP
6hematoxylin449.7MUC1, INHA
7estrone44 28 24 1112.7AFP, PGR
8trastuzumab44 50 1111.7PGR, MUC1
9progestin449.7MUC1, PGR
10polyethylene glycol449.6MUC1, AFP
11biotin44 24 1111.6MUC1, INHA
12galactose449.6MUC1, AFP
13gold449.5MUC1, AFP
14sialic acid449.4MUC1, AFP
15cyclophosphamide44 50 1111.4PGR, AFP
16cytosine44 2410.4WT1, AFP
17agarose449.4INHA, MUC1
18dihydrotestosterone44 28 24 1112.4MUC1, PGR
19vincristine44 50 1111.4WT1, AFP
20thyroxine44 2410.3PGR, AFP
21mifepristone44 28 61 1112.2MUC1, PGR, AFP
22adriamycin449.2AFP, PGR, MUC1
23folate449.2AFP, PGR, MUC1
24dmso449.2MUC1, PGR, AFP
25methotrexate50 44 1111.2AFP, PGR, MUC1
265fluorouracil449.2MUC1, PGR, AFP
27agar449.2MUC1, PGR, AFP
28alanine449.2INHA, AFP, PGR
29dexamethasone44 50 28 1112.1MUC1, PGR, AFP
30doxorubicin44 50 1111.0WT1, PGR, AFP
31glutamine449.0WT1, PGR, AFP
32oligonucleotide449.0INHA, AFP, WT1
33forskolin44 50 1111.0INHA, MUC1, WT1
34b 723449.0AFP, MUC1, WT1
35chloramphenicol44 2 50 1111.9AFP, MUC1, WT1
36butyrate448.9AFP, MUC1, WT1
37thymidine44 249.9AFP, MUC1, WT1
38creatinine448.9WT1, MUC1, AFP
39estradiol44 24 1110.8INHA, AFP, PGR, MUC1
40hyaluronic acid44 249.7WT1, MUC1
41threonine448.7WT1, MUC1, AFP
42steroid448.6WT1, PGR, AFP, INHA
43ribonucleic acid448.5WT1, MUC1, PGR, INHA
44vegf448.4AFP, PGR, MUC1, WT1
45retinoic acid44 249.4WT1, MUC1, PGR, AFP
46tyrosine448.4INHA, AFP, MUC1, WT1
47paraffin448.0WT1, MUC1, PGR, AFP, INHA
48progesterone44 28 61 24 1112.0INHA, AFP, PGR, MUC1, WT1
49testosterone44 61 24 1111.0WT1, MUC1, PGR, AFP, INHA
50estrogen448.0INHA, AFP, PGR, MUC1, WT1

GO Terms for genes affiliated with Sertoli-Leydig Cell Tumor

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Biological processes related to Sertoli-Leydig Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ovulation from ovarian follicleGO:0015429.3PGR, AFP
2regulation of cell cycleGO:0517269.3DICER1, INHA
3male gonad developmentGO:0085849.2WT1, INHA

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