SARS
MCID: SVR001
MIFTS: 58

Severe Acute Respiratory Syndrome (SARS) malady

Respiratory diseases, Infectious diseases categories

Summaries for Severe Acute Respiratory Syndrome

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in respiratory tract, has material basis in sars coronavirus (sars-cov), which is transmitted by droplet spread of respiratory secretions, transmitted by ingestion of contaminated food, or transmitted by fomites. the infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards: Severe Acute Respiratory Syndrome, also known as SARS, is related to influenza and hepatitis, and has symptoms including hypoxia, dry cough and body aches. An important gene associated with Severe Acute Respiratory Syndrome is CLEC4M (C-type lectin domain family 4, member M), and among its related pathways is Influenza A. The compounds 2,5-oligoadenylate and rantes have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and t cells.

CDC:3 Remembering the 2003 global SARS outbreak...More

Wikipedia:63 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Aliases & Classifications for Severe Acute Respiratory Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

severe acute respiratory syndrome 8 42 10 48 60
sars 8 42 48
sars-associated coronavirus 48
sars-cov infection 8
sars-cov 48


External Ids:

Disease Ontology8 DOID:2945
MeSH34 D045169
NCIt39 C85064
ICD9CM27 079.82
MESH via Orphanet35 D045169
SNOMED-CT56 398447004
SNOMED-CT via Orphanet57 398447004
UMLS via Orphanet61 C1175175
ICD10 via Orphanet26 U04.9
ICD1025 U04

Related Diseases for Severe Acute Respiratory Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to severe acute respiratory syndrome

Clinical Features for Severe Acute Respiratory Syndrome

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8Disease Ontology
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Symptoms:

8
  • hypoxia
  • dry cough
  • body aches
  • headache
  • fever

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Severe Acute Respiratory Syndrome

Drug clinical trials:

Search ClinicalTrials for Severe Acute Respiratory Syndrome

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Search CenterWatch for Severe Acute Respiratory Syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

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Anatomical Context for Severe Acute Respiratory Syndrome

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

32
Lung, T cells, Testes, Kidney, Thyroid, Liver, Placenta, Skin, Salivary gland, B cells, Brain, Spleen, Bone

FMA organs/tissues related to Severe Acute Respiratory Syndrome:

14
Respiratory tract

Animal Models for Severe Acute Respiratory Syndrome or affiliated genes

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Publications for Severe Acute Respiratory Syndrome

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50PubMed
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Articles related to Severe Acute Respiratory Syndrome:

(show top 50)    (show all 598)
idTitleAuthorsYear
1
Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus. (23449793)
2013
2
Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivo. (22820404)
2012
3
Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus. (22915798)
2012
4
Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease. (22072787)
2012
5
Calreticulin as a hydrophilic chimeric molecular adjuvant enhances IgG responses to the spike protein of severe acute respiratory syndrome coronavirus. (22530918)
2012
6
Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. (21325420)
2011
7
Distinct severe acute respiratory syndrome coronavirus-induced acute lung injury pathways in two different nonhuman primate species. (21325418)
2011
8
A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms. (20573835)
2010
9
Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination events. (20071579)
2010
10
Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome. (19570864)
2009
11
Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a. (19748524)
2009
12
Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients. (19439011)
2009
13
Prolonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report. (19830103)
2009
14
Infectivity of severe acute respiratory syndrome during its incubation period. (20337224)
2009
15
Investigation of the second wave (phase 2) of severe acute respiratory syndrome (SARS) in Toronto, Canada. What happened? (18404809)
2008
16
Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors. (18442051)
2008
17
Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase. (18082623)
2008
18
The SARS (Severe Acute Respiratory Syndrome) pandemic in Hong Kong: effects on the subjective wellbeing of elderly and younger people. (19023726)
2008
19
A comparison of infection control program resources, activities, and antibiotic resistant organism rates in Canadian acute care hospitals in 1999 and 2005: pre- and post-severe acute respiratory syndrome. (18834747)
2008
20
Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus entry and cell-cell fusion. (18199653)
2008
21
Severe acute respiratory syndrome (SARS) coronavirus. (17458774)
2007
22
Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein. (17428862)
2007
23
Interaction of a peptide from the pre-transmembrane domain of the severe acute respiratory syndrome coronavirus spike protein with phospholipid membranes. (18020324)
2007
24
How to provide an effective primary health care in fighting against severe acute respiratory syndrome: the experiences of two cities. (17276791)
2007
25
Recent patents on treatment of severe acute respiratory syndrome (SARS). (18221160)
2007
26
Comparison of immunoglobulin G responses to the spike and nucleocapsid proteins of severe acute respiratory syndrome (SARS) coronavirus in patients with SARS. (17475765)
2007
27
Nosocomial transmission of severe acute respiratory syndrome: better quality of evidence is needed. (18190333)
2007
28
Hindsight: a re-analysis of the severe acute respiratory syndrome outbreak in Beijing. (17555781)
2007
29
Possible meteorological influence on the severe acute respiratory syndrome (SARS) community outbreak at Amoy Gardens, Hong Kong. (17941402)
2007
30
Non-parametric estimation of the case fatality ratio with competing risks data: an application to Severe Acute Respiratory Syndrome (SARS). (16981181)
2007
31
Protection from infection with severe acute respiratory syndrome coronavirus in a Chinese hamster model by equine neutralizing F(ab')2. (17931120)
2007
32
Impact of severe acute respiratory syndrome care on the general health status of healthcare workers in taiwan. (17230391)
2007
33
Adverse events associated with high-dose ribavirin: evidence from the Toronto outbreak of severe acute respiratory syndrome. (17381375)
2007
34
Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry. (17715238)
2007
35
Immune responses against severe acute respiratory syndrome coronavirus induced by virus-like particles in mice. (17680799)
2007
36
Inhibition of severe acute respiratory syndrome-associated coronavirus infection by equine neutralizing antibody in golden Syrian hamsters. (17425434)
2007
37
A prospective hospital-based study of the clinical impact of non-severe acute respiratory syndrome (Non-SARS)-related human coronavirus infection. (16983613)
2006
38
Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy. (16873249)
2006
39
Carboxyl terminus of severe acute respiratory syndrome coronavirus nucleocapsid protein: self-association analysis and nucleic acid binding characterization. (17002283)
2006
40
Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation. (16912115)
2006
41
Molecular diagnosis of severe acute respiratory syndrome. (16916262)
2006
42
Hosting the severe acute respiratory syndrome coronavirus: specific cell factors required for infection. (16803585)
2006
43
Orchitis: a complication of severe acute respiratory syndrome (SARS). (16237152)
2006
44
Association of RANTES with the replication of severe acute respiratory syndrome coronavirus in THP-1 cells. (15851378)
2005
45
Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis. (16163626)
2005
46
Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus. (15596135)
2005
47
Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. (15564512)
2004
48
Severe acute respiratory syndrome: What have we learned two years later? (18159508)
2004
49
Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. (12794395)
2003
50
Severe acute respiratory syndrome. (17643010)
2003

Genetic Variations for Severe Acute Respiratory Syndrome

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Expression for genes affiliated with Severe Acute Respiratory Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for genes affiliated with Severe Acute Respiratory Syndrome

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29KEGG
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Pathways related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5MX1, CXCL10, CLEC4M, MCRS1, CD209

Compounds for genes affiliated with Severe Acute Respiratory Syndrome

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
12,5-oligoadenylate4410.7MX1, CXCL10, IFNL1
2rantes4410.7ICAM3
3mannose4410.7ICAM3, JPH4, CD209, CLEC4M
4dexamethasone44 49 28 1113.6ICAM3, SAA4, CD209, CXCL10, CXCL9, SULT1A3
5ifn-alpha4410.6MX1, CXCL9, CXCL10
6carbohydrates4410.5CLEC4M, CD209, ICAM3
7neopterin4410.5SAA4, CXCL10, MX1
8allergens4410.4CXCL10, CLEC4M, CD209
9calcium44 49 11 2413.3ICAM3, SAA4, CTRL, CD209, MCRS1, CLEC4M

GO Terms for genes affiliated with Severe Acute Respiratory Syndrome

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16Gene Ontology
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Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5ACE2, CXCL9, CXCL10, CLEC4M, CD209, SAA4

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1viral attachment to host cellGO:01906210.7CLEC4M, CD209
2intracellular virion transportGO:04679510.7CLEC4M, CD209
3peptide antigen transportGO:04696810.6CLEC4M, CD209
4defense response to virusGO:05160710.6IFNL1, CXCL10, CXCL9, MX1
5cell-cell recognitionGO:00998810.5CLEC4M, CD209
6leukocyte cell-cell adhesionGO:00715910.5CLEC4M, CD209
7viral genome replicationGO:01907910.4CD209, CLEC4M
8antigen processing and presentationGO:01988210.2CLEC4M, CD209

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:03024610.5CLEC4M, CLEC4G, CD209
2virion bindingGO:04679010.4CLEC4M, CD209
3mannose bindingGO:00553710.2CLEC4M, CD209

Products for genes affiliated with Severe Acute Respiratory Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Severe Acute Respiratory Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet