SARS
MCID: SVR001
MIFTS: 58

Severe Acute Respiratory Syndrome (SARS) malady

Respiratory diseases, Infectious diseases categories

Summaries for Severe Acute Respiratory Syndrome

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in respiratory tract, has material basis in sars coronavirus (sars-cov), which is transmitted by droplet spread of respiratory secretions, transmitted by ingestion of contaminated food, or transmitted by fomites. the infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards: Severe Acute Respiratory Syndrome, also known as SARS, is related to influenza and hepatitis, and has symptoms including hypoxia, dry cough and body aches. An important gene associated with Severe Acute Respiratory Syndrome is CLEC4M (C-type lectin domain family 4, member M), and among its related pathways is Influenza A. The compounds 2,5-oligoadenylate and rantes have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and t cells.

CDC:3 Remembering the 2003 global SARS outbreak...More

Wikipedia:63 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Aliases & Classifications for Severe Acute Respiratory Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

severe acute respiratory syndrome 8 42 10 48 60
sars 8 42 48
sars-associated coronavirus 48
sars-cov infection 8
sars-cov 48


External Ids:

Disease Ontology8 DOID:2945
MeSH34 D045169
NCIt39 C85064
ICD9CM27 079.82
MESH via Orphanet35 D045169
SNOMED-CT56 398447004
SNOMED-CT via Orphanet57 398447004
UMLS via Orphanet61 C1175175
ICD10 via Orphanet26 U04.9
ICD1025 U04

Related Diseases for Severe Acute Respiratory Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to severe acute respiratory syndrome

Clinical Features for Severe Acute Respiratory Syndrome

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8Disease Ontology
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Symptoms:

8
  • hypoxia
  • dry cough
  • body aches
  • headache
  • fever

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Severe Acute Respiratory Syndrome

Drug clinical trials:

Search ClinicalTrials for Severe Acute Respiratory Syndrome

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Search CenterWatch for Severe Acute Respiratory Syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

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Anatomical Context for Severe Acute Respiratory Syndrome

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

32
Lung, T cells, Testes, Kidney, Liver, Thyroid, Spleen, B cells, Salivary gland, Brain, Placenta, Bone, Skin

FMA organs/tissues related to Severe Acute Respiratory Syndrome:

14
Respiratory tract

Animal Models for Severe Acute Respiratory Syndrome or affiliated genes

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Publications for Severe Acute Respiratory Syndrome

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50PubMed
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Articles related to Severe Acute Respiratory Syndrome:

(show top 50)    (show all 598)
idTitleAuthorsYear
1
ABO Blood Type A is Associated with Increased Risk of Acute Respiratory Distress Syndrome in Caucasians Following both Major Trauma and Severe Sepsis. (24385226)
2014
2
Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells. (23365422)
2013
3
Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome. (22740477)
2012
4
Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation. (23035226)
2012
5
Two palmitylated cysteine residues of the severe acute respiratory syndrome coronavirus spike (S) protein are critical for S incorporation into virus-like particles, but not for M-S co-localization. (22238235)
2012
6
Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease. (22391227)
2012
7
Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus. (20980507)
2011
8
Quantitative proteomics analysis reveals BAG3 as a potential target to suppress severe acute respiratory syndrome coronavirus replication. (20392858)
2010
9
Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway. (20484496)
2010
10
Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16. (20699222)
2010
11
Corticosteroids as adjunctive therapy in severe blastomycosis-induced acute respiratory distress syndrome in an immunosuppressed patient. (20507238)
2010
12
Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice. (20406307)
2010
13
T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice. (20610717)
2010
14
Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain. (19324051)
2009
15
Translational control of the subgenomic RNAs of severe acute respiratory syndrome coronavirus. (19363699)
2009
16
Severe acute respiratory syndrome-associated coronavirus infection in Toronto children: a second look. (19117866)
2009
17
Combined use of extracorporeal membrane oxygenation and activated protein C for severe acute respiratory distress syndrome and septic shock. (19577093)
2009
18
Human LINE1 endonuclease domain as a putative target of SARS-associated autoantibodies involved in the pathogenesis of severe acute respiratory syndrome. (18466680)
2008
19
Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism. (18448520)
2008
20
Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation. (18632968)
2008
21
Co-infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice. (18380809)
2008
22
Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations. (17977841)
2008
23
Tick talk: unusually severe case of tick-borne relapsing fever with acute respiratory distress syndrome--case report and review of the literature. (19099321)
2008
24
Staff perception and institutional reporting: two views of infection control compliance in British Columbia and Ontario three years after an outbreak of severe acute respiratory syndrome. (18485532)
2008
25
Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain. (18305043)
2008
26
Learning from the severe acute respiratory syndrome (SARS) epidemic. (18179533)
2008
27
Thrombopoietin levels increased in patients with severe acute respiratory syndrome. (18314161)
2008
28
Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. (17507479)
2007
29
Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS. (17331558)
2007
30
Induction of T-cell response by a DNA vaccine encoding a novel HLA-A*0201 severe acute respiratory syndrome coronavirus epitope. (17629360)
2007
31
Severe acute respiratory syndrome in children. (17195709)
2007
32
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters. (17381079)
2007
33
Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen. (17872527)
2007
34
Expression, purification and characterization of recombinant severe acute respiratory syndrome coronavirus non-structural protein 1. (17187987)
2007
35
The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese. (17540042)
2007
36
Knowledge of and attitudes toward severe acute respiratory syndrome among a cohort of dental patients in Hong Kong following a major local outbreak. (17405470)
2007
37
Pathology and virus dispersion in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus via different inoculation routes. (18039277)
2007
38
Dying and caring on the edge: Taiwan's surviving nurses' reflections on taking care of patients with severe acute respiratory syndrome. (17996803)
2007
39
Molecular pathology in the lungs of severe acute respiratory syndrome patients. (17255322)
2007
40
Pathology of the thyroid in severe acute respiratory syndrome. (16996569)
2007
41
The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells. (16876844)
2006
42
Spatial dynamics of an epidemic of severe acute respiratory syndrome in an urban area. (17242832)
2006
43
A trimerizing GxxxG motif is uniquely inserted in the severe acute respiratory syndrome (SARS) coronavirus spike protein transmembrane domain. (16981695)
2006
44
Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus. (15688292)
2005
45
Serum neopterin for early assessment of severity of severe acute respiratory syndrome. (15925828)
2005
46
Can routine laboratory tests discriminate between severe acute respiratory syndrome and other causes of community-acquired pneumonia? (15791504)
2005
47
Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection. (16170752)
2005
48
Renal hypouricemia is an ominous sign in patients with severe acute respiratory syndrome. (15696447)
2005
49
Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). (15221932)
2004
50
Severe acute respiratory syndrome complicated by spontaneous pneumothorax. (15189961)
2004

Genetic Variations for Severe Acute Respiratory Syndrome

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Expression for genes affiliated with Severe Acute Respiratory Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for genes affiliated with Severe Acute Respiratory Syndrome

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29KEGG
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Pathways related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.5MX1, CXCL10, CLEC4M, MCRS1, CD209

Compounds for genes affiliated with Severe Acute Respiratory Syndrome

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
12,5-oligoadenylate4410.7MX1, CXCL10, IFNL1
2rantes4410.7ICAM3
3mannose4410.7ICAM3, JPH4, CD209, CLEC4M
4dexamethasone44 49 28 1113.6ICAM3, SAA4, CD209, CXCL10, CXCL9, SULT1A3
5ifn-alpha4410.6MX1, CXCL9, CXCL10
6carbohydrates4410.5CLEC4M, CD209, ICAM3
7neopterin4410.5SAA4, CXCL10, MX1
8allergens4410.4CXCL10, CLEC4M, CD209
9calcium44 49 11 2413.3ICAM3, SAA4, CTRL, CD209, MCRS1, CLEC4M

GO Terms for genes affiliated with Severe Acute Respiratory Syndrome

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16Gene Ontology
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Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5ACE2, CXCL9, CXCL10, CLEC4M, CD209, SAA4

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1viral attachment to host cellGO:01906210.7CLEC4M, CD209
2intracellular virion transportGO:04679510.7CLEC4M, CD209
3peptide antigen transportGO:04696810.6CLEC4M, CD209
4defense response to virusGO:05160710.6IFNL1, CXCL10, CXCL9, MX1
5cell-cell recognitionGO:00998810.5CLEC4M, CD209
6leukocyte cell-cell adhesionGO:00715910.5CLEC4M, CD209
7viral genome replicationGO:01907910.4CD209, CLEC4M
8antigen processing and presentationGO:01988210.2CLEC4M, CD209

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:03024610.5CLEC4M, CLEC4G, CD209
2virion bindingGO:04679010.4CLEC4M, CD209
3mannose bindingGO:00553710.2CLEC4M, CD209

Products for genes affiliated with Severe Acute Respiratory Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Severe Acute Respiratory Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet