SARS
MCID: SVR001
MIFTS: 59

Severe Acute Respiratory Syndrome (SARS) malady

Rare diseases, Respiratory diseases, Infectious diseases, Fetal diseases categories
Download this MalaCard

Summaries for Severe Acute Respiratory Syndrome

About this section


Fully expand this MalaCard
Disease Ontology:8 A viral infectious disease that results in infection located in respiratory tract, has material basis in sars coronavirus (sars-cov), which is transmitted by droplet spread of respiratory secretions, transmitted by ingestion of contaminated food, or transmitted by fomites. the infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards based summary: Severe Acute Respiratory Syndrome, also known as SARS, is related to malaria and hepatitis c, and has symptoms including An important gene associated with Severe Acute Respiratory Syndrome is CLEC4M (C-type lectin domain family 4, member M), and among its related pathways are Protein digestion and absorption and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds groalpha and pdtc have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and t cells, and related mouse phenotype homeostasis/metabolism.

CDC:3 Remembering the 2003 global SARS outbreak...More

Wikipedia:65 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Aliases & Classifications for Severe Acute Respiratory Syndrome

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Severe Acute Respiratory Syndrome, Aliases & Descriptions:

Name: Severe Acute Respiratory Syndrome 8 42 10 48 62
Sars 8 42 48
Sars-Associated Coronavirus 48 62
 
Sars-Cov Infection 8
Sars-Cov 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
severe acute respiratory syndrome:
Age of onset: Variable


External Ids:

Disease Ontology8 DOID:2945
NCIt39 C85064
MeSH34 D045169
ICD9CM27 079.82
SNOMED-CT57 398447004
MESH via Orphanet35 D045169
ICD10 via Orphanet26 U04.9
UMLS via Orphanet63 C1175175
ICD1025 U04

Related Diseases for Severe Acute Respiratory Syndrome

About this section

Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to severe acute respiratory syndrome

Symptoms for Severe Acute Respiratory Syndrome

About this section

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Severe Acute Respiratory Syndrome

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

About this section

Anatomical Context for Severe Acute Respiratory Syndrome

About this section

MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

32
Lung, T cells, Testes, Kidney, Liver, Thyroid, Bone, Spleen, Brain, Salivary gland, Skin, Placenta, B cells

FMA organs/tissues related to Severe Acute Respiratory Syndrome:

14
Respiratory tract

Animal Models for Severe Acute Respiratory Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Severe Acute Respiratory Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0CD209, BCL2L2, ACE2, CXCL10, CLEC4M, FCER2

Publications for Severe Acute Respiratory Syndrome

About this section

Articles related to Severe Acute Respiratory Syndrome:

(show top 50)    (show all 590)
idTitleAuthorsYear
1
Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase. (23536667)
2013
2
Severe acute respiratory syndrome (SARS) and the rhetorical construction of "bad" scientific work. (22586846)
2012
3
Potential cross-reactivity of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid (N)-based IgG ELISA assay for plasma samples from HIV-1 positive intravenous drug users (IDUs). (22983073)
2012
4
Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge. (22345460)
2012
5
OPV-like poliovirus type 1 detection in patients with severe acute respiratory syndrome. (22371233)
2012
6
Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein. (21524776)
2011
7
Quantitative proteomics analysis reveals BAG3 as a potential target to suppress severe acute respiratory syndrome coronavirus replication. (20392858)
2010
8
Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway. (20484496)
2010
9
The impact of epidemic outbreak: the case of severe acute respiratory syndrome (SARS) and suicide among older adults in Hong Kong. (20418214)
2010
10
The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated. (20409569)
2010
11
Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme. (19374142)
2009
12
Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain. (19324051)
2009
13
Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15. (18045871)
2008
14
Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection. (18697825)
2008
15
siRNA silencing of angiotensin-converting enzyme 2 reduced severe acute respiratory syndrome-associated coronavirus replications in Vero E6 cells. (18449585)
2008
16
Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease. (17416434)
2008
17
A revisit on older adults suicides and Severe Acute Respiratory Syndrome (SARS) epidemic in Hong Kong. (18500689)
2008
18
Characterization of the prefusion and transition states of severe acute respiratory syndrome coronavirus S2-HR2. (18540634)
2008
19
Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. (18178835)
2008
20
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase. (18295820)
2008
21
Sensitive and specific enzyme-linked immunosorbent assay using chemiluminescence for detection of severe acute respiratory syndrome viral infection. (18032623)
2008
22
Investigation of the second wave (phase 2) of severe acute respiratory syndrome (SARS) in Toronto, Canada. What happened? (18404809)
2008
23
A test for constant fatality rate of an emerging epidemic: with applications to severe acute respiratory syndrome in Hong Kong and Beijing. (18047531)
2008
24
Human LINE1 endonuclease domain as a putative target of SARS-associated autoantibodies involved in the pathogenesis of severe acute respiratory syndrome. (18466680)
2008
25
Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. (17507479)
2007
26
Severe acute respiratory syndrome (SARS) coronavirus. (17458774)
2007
27
Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein. (17428862)
2007
28
Pathology and pathogenesis of severe acute respiratory syndrome. (17392154)
2007
29
Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS. (17331558)
2007
30
Induction of T-cell response by a DNA vaccine encoding a novel HLA-A*0201 severe acute respiratory syndrome coronavirus epitope. (17629360)
2007
31
Interaction of a peptide from the pre-transmembrane domain of the severe acute respiratory syndrome coronavirus spike protein with phospholipid membranes. (18020324)
2007
32
The synergistic interaction of interferon types I and II leads to marked reduction in severe acute respiratory syndrome-associated coronavirus replication and increase in the expression of mRNAs for interferon-induced proteins. (17191018)
2007
33
Severe acute respiratory syndrome--retrospect and lessons of 2004 outbreak in China. (17319269)
2006
34
The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells. (16876844)
2006
35
Multicenter comparison of nucleic acid extraction methods for detection of severe acute respiratory syndrome coronavirus RNA in stool specimens. (16891478)
2006
36
Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. (16581910)
2006
37
Rewiring the severe acute respiratory syndrome coronavirus (SARS-CoV) transcription circuit: engineering a recombination-resistant genome. (16891412)
2006
38
The possible mechanism of lung injury induced by severe acute respiratory syndrome coronavirus spike glycoprotein]. (17129463)
2006
39
Severe acute respiratory syndrome coronavirus 7a accessory protein is a viral structural protein. (16840309)
2006
40
Knowledge of severe acute respiratory syndrome among community physicians, nurses, and emergency medical responders. (16892883)
2006
41
Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms. (16652313)
2006
42
Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells. (16684538)
2006
43
Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis. (15919935)
2005
44
Association of RANTES with the replication of severe acute respiratory syndrome coronavirus in THP-1 cells. (15851378)
2005
45
Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. (16195357)
2005
46
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. (15496474)
2004
47
Severe acute respiratory syndrome: clinical and laboratory manifestations. (18458712)
2004
48
Altered p38 mitogen-activated protein kinase expression in different leukocytes with increment of immunosuppressive mediators in patients with severe acute respiratory syndrome. (15187168)
2004
49
Late-stage adult respiratory distress syndrome caused by severe acute respiratory syndrome: abnormal findings at thin-section CT. (14752179)
2004
50
Clinical characteristics and mechanism of liver injury in patients with severe acute respiratory syndrome]. (12939186)
2003

Variations for Severe Acute Respiratory Syndrome

About this section

Expression for genes affiliated with Severe Acute Respiratory Syndrome

About this section
Expression patterns in normal tissues for genes affiliated with Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for genes affiliated with Severe Acute Respiratory Syndrome

About this section

Compounds for genes affiliated with Severe Acute Respiratory Syndrome

About this section

Compounds related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1groalpha449.7CXCL5, CXCL10
2pdtc449.7CTRL, FCER2
3tarc449.6CXCL10, CXCL5
4ccl344 2810.6CXCL5, CXCL10
5ccl444 2810.5CXCL10, CXCL5
6galactose449.5CD209, CLEC4M, FCER2
7mannose449.5CD209, CLEC4M, FCER2
8histamine44 28 2411.5CTRL, CXCL10, FCER2
9neopterin449.3CXCL10, FCER2
10rantes449.3CXCL10, CXCL5, CD209
11leukotriene b444 61 2411.3FCER2, CXCL10, CXCL5
12fmlp449.3CTRL, CXCL5, FCER2
13genistein44 28 61 2 24 1114.2FCER2, SULT1A3, CXCL10, CTRL
14allergens449.2CD209, CXCL10, CLEC4M, FCER2
15pge2448.9CXCL5, CXCL10, FCER2
16superoxide44 249.8FCER2, CXCL5, ACE2, CTRL
17zinc44 249.7CTRL, ACE2, CXCL5, FCER2
18dexamethasone44 50 28 1111.5FCER2, SULT1A3, CXCL10, CXCL5, CD209
19tyrosine448.4FCER2, CXCL10, CXCL5, CD209, CTRL
20nitric oxide44 24 1110.4ACE2, CXCL5, CXCL10, SULT1A3, FCER2
21calcium44 50 24 1111.2FCER2, CLEC4M, CXCL10, CXCL5, CD209, CTRL

GO Terms for genes affiliated with Severe Acute Respiratory Syndrome

About this section

Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7CTRL, ACE2, CXCL5, CXCL10
2extracellular regionGO:0055768.0CD209, ACE2, CXCL5, CXCL10, CLEC4M

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1virion attachment to host cellGO:0190629.9CD209, CLEC4M
2peptide antigen transportGO:0469689.9CD209, CLEC4M
3cell-cell recognitionGO:0099889.9CD209, CLEC4M
4viral genome replicationGO:0190799.8CLEC4M, CD209
5modulation by virus of host morphology or physiologyGO:0190489.7CLEC4M, CD209
6antigen processing and presentationGO:0198829.7CD209, CLEC4M
7intracellular transport of virusGO:0757339.6CD209, CLEC4M
8leukocyte cell-cell adhesionGO:0071599.4CD209, CLEC4M

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virion bindingGO:0467909.8CLEC4M, CD209
2mannose bindingGO:0055379.6CLEC4M, CD209
3chemokine activityGO:0080099.5CXCL10, CXCL5
4peptide antigen bindingGO:0426059.4CD209, CLEC4M
5carbohydrate bindingGO:0302469.2FCER2, CLEC4M, CD209

Products for genes affiliated with Severe Acute Respiratory Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Severe Acute Respiratory Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet