MCID: SVR001
MIFTS: 58

Severe Acute Respiratory Syndrome

Categories: Rare diseases, Respiratory diseases, Fetal diseases, Infectious diseases

Aliases & Classifications for Severe Acute Respiratory Syndrome

MalaCards integrated aliases for Severe Acute Respiratory Syndrome:

Name: Severe Acute Respiratory Syndrome 12 72 49 3 41 14 69
Sars 12 49 3
Sars-Cov Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2945
ICD10 32 J12.81 U04
ICD9CM 34 079.82
MeSH 41 D045169
NCIt 46 C85064
SNOMED-CT 64 398447004
UMLS 69 C1175175

Summaries for Severe Acute Respiratory Syndrome

Disease Ontology : 12 A viral infectious disease that results_in infection located in respiratory tract, has material basis in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards based summary : Severe Acute Respiratory Syndrome, also known as sars, is related to sarcoidosis 1 and avian influenza, and has symptoms including fever, headache and body aches. An important gene associated with Severe Acute Respiratory Syndrome is ACE2 (Angiotensin I Converting Enzyme 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Lopinavir and Ritonavir have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and testes, and related phenotype is immune system.

CDC : 3 This website is archived for historical purposes and is no longer being maintained or updated.

Wikipedia : 72 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Related Diseases for Severe Acute Respiratory Syndrome

Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Severe Acute Respiratory Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 sarcoidosis 1 31.4 CCL2 CCL5 CXCL10 IFNG TNF
2 avian influenza 30.4 CXCL10 CXCL8 TNF
3 influenza 29.8 CCL5 IFNA1 IFNB1 IFNG TMPRSS2
4 west nile virus 29.5 CD209 CLEC4M IFNA1 IRF3
5 gastroenteritis 29.5 CXCL8 IFNA1 IFNG TNF
6 pneumonia 29.2 CCL2 CCL5 CD40LG CXCL8 TNF
7 encephalitis 29.1 CCL2 CCL5 CD209 CLEC4M CXCL10 IRF3
8 hemorrhagic fever 29.0 CD209 CD40LG IFNG TNF
9 hepatitis c 27.7 CLEC4M CXCL10 IFNA1 IFNB1 IFNG IRF3
10 sarcosinemia 11.3
11 neurodevelopmental disorder with microcephaly, ataxia, and seizures 11.2
12 epidemic typhus 11.2
13 autosomal recessive non-syndromic intellectual disability 10.9
14 herpes simplex virus keratitis 10.5 CCL2 CXCL8
15 scorpion envenomation 10.5 CCL5 TNF
16 staphylococcal toxic shock syndrome 10.4 IFNG TNF
17 israeli tick typhus 10.4 CCL2 CXCL8
18 autoimmune myocarditis 10.4 IFNG TNF
19 acute respiratory coronavirus infection 10.4
20 engraftment syndrome 10.4 CXCL8 IFNA1
21 stromal keratitis 10.4 CCL2 CXCL10 TNF
22 primary peritoneal carcinoma 10.4 CXCL10 CXCL8 IFNG
23 oral erosive lichen 10.4 IFNA1 IFNB1
24 invasive aspergillosis 10.3 CXCL10 CXCL8 IFNG
25 tungiasis 10.3 CXCL8 TNF
26 extrinsic allergic alveolitis 10.3 CCL2 CCL5 CXCL8
27 stachybotrys chartarum 10.3 CCL2 CCL5 TNF
28 streptococcal toxic-shock syndrome 10.3 CXCL8 TNF
29 paracoccidioidomycosis 10.3 CXCL10 IFNG TNF
30 idiopathic interstitial pneumonia 10.3 CCL2 CXCL8 IFNG
31 orofacial granulomatosis 10.3 CCL5 IFNG TNF
32 tuberculous meningitis 10.3 CCL2 CXCL8 TNF
33 pyelonephritis 10.3 CCL2 CXCL8 TNF
34 crohn's colitis 10.3 CXCL8 IFNG TNF
35 meconium aspiration syndrome 10.3 CXCL8 IFNG TNF
36 silicosis 10.2 CCL2 CXCL8 TNF
37 null-cell leukemia 10.2 IFNA1 TNF
38 aseptic meningitis 10.2 CXCL8 IFNG TNF
39 chronic beryllium disease 10.2 IFNG TNF
40 alopecia areata 10.2 CXCL10 IFNG TNF
41 chorioamnionitis 10.2 CCL2 CXCL8 TNF
42 filariasis 10.2 CCL5 IFNG TNF
43 cytomegalovirus infection 10.2 CXCL8 IFNG TNF
44 pneumoconiosis 10.2 CCL2 CXCL8 TNF
45 alcoholic hepatitis 10.2 CCL2 CXCL8 TNF
46 allergic asthma 10.2 CCL5 CXCL8 IFNG
47 tonsillitis 10.2 CXCL8 IFNG TNF
48 bronchiolitis obliterans 10.2 CXCL8 IFNG TNF
49 bronchial disease 10.2 CCL5 CXCL8 TNF
50 keratoconjunctivitis 10.2 CXCL8 IFNG TNF

Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to Severe Acute Respiratory Syndrome

Symptoms & Phenotypes for Severe Acute Respiratory Syndrome

Symptoms:

12
  • fever
  • headache
  • body aches
  • dry cough
  • hypoxia

UMLS symptoms related to Severe Acute Respiratory Syndrome:


snoring, pruritus, fever, coughing

MGI Mouse Phenotypes related to Severe Acute Respiratory Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 ACE2 CCL2 CCL5 CD40LG CLEC4M CXCL10

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

Drugs for Severe Acute Respiratory Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lopinavir Approved Phase 2, Phase 3 192725-17-0 92727
2
Ritonavir Approved, Investigational Phase 2, Phase 3 155213-67-5 392622
3
Benzocaine Approved, Investigational Phase 2, Phase 3 1994-09-7, 94-09-7 2337
4
Interferon beta-1b Approved Phase 2, Phase 3 145155-23-3
5 tannic acid Approved, Nutraceutical Phase 2, Phase 3
6 Anti-HIV Agents Phase 2, Phase 3
7 Anti-Infective Agents Phase 2, Phase 3
8 Anti-Retroviral Agents Phase 2, Phase 3
9 Antiviral Agents Phase 2, Phase 3
10 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
11 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
12 HIV Protease Inhibitors Phase 2, Phase 3,Phase 1
13
protease inhibitors Phase 2, Phase 3,Phase 1
14 interferons Phase 2, Phase 3
15 Adjuvants, Immunologic Phase 2, Phase 3,Phase 1
16 Interferon-beta Phase 2, Phase 3
17 Interferon-alpha Phase 2
18
Sorbitol Approved Phase 1 50-70-4 5780
19
Glutamic Acid Approved, Nutraceutical Phase 1 56-86-0 33032
20 Vaccines Phase 1
21 Antibodies Phase 1
22 Immunoglobulins Phase 1
23 gamma-Globulins Phase 1
24 Immunoglobulins, Intravenous Phase 1
25 Rho(D) Immune Globulin Phase 1
26 Antibodies, Monoclonal Phase 1
27 Somatomedin B Phase 1
28 Myeloma Proteins Phase 1
29 Paraproteins Phase 1
30
Ribavirin Approved 36791-04-5 37542
31 Antimetabolites

Interventional clinical trials:

(show all 31)

# Name Status NCT ID Phase Drugs
1 MERS-CoV Infection tReated With A Combination of Lopinavir /Ritonavir and Interferon Beta-1b Recruiting NCT02845843 Phase 2, Phase 3 Combination of Lopinavir /Ritonavir and Interferon beta-1b;Placebo
2 Study of Alferon® LDO (Low Dose Oral) in Normal Volunteers Completed NCT00215826 Phase 2 Alferon LDO
3 Phase I, Open Label Dose Ranging Safety Study of GLS-5300 in Healthy Volunteers Unknown status NCT02670187 Phase 1
4 Phase I Study of a Vaccine for Severe Acute Respiratory Syndrome (SARS) Completed NCT00099463 Phase 1 Vaccine;VRC-SRSDNA015-00-VP
5 Saudi Outcomes of ECMO-treated MERS-CoV Patients Completed NCT02627378 Phase 1
6 A Safety, Tolerability, Pharmacokinetics and Immunogenicity Trial of Co-administered MERS-CoV Antibodies REGN3048 and REGN3051 Recruiting NCT03301090 Phase 1
7 Safety, Tolerability, and Pharmacokinetics of SAB-301 in Healthy Adults Active, not recruiting NCT02788188 Phase 1
8 Safety and Immunogenicity of a Candidate MERS-CoV Vaccine (MERS001) Not yet recruiting NCT03399578 Phase 1
9 Phase I Dose Escalation SARS-CoV Recombinant S Protein, With and Without Adjuvant, Vaccine Study Withdrawn NCT01376765 Phase 1 Aluminum hydroxide adjuvant (Alhydrogel®)
10 SARS Coronavirus Vaccine (SARS-CoV) Withdrawn NCT00533741 Phase 1 Aluminum hydroxide;Placebo
11 A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome Unknown status NCT00578825 Lopinavir / Ritonavir plus Ribavirin
12 Induction of Cytokines in Human Monocytes by SARS-CoV in Adults and Children Unknown status NCT00173563
13 Investigating Severe Acute Respiratory Syndrome (SARS) Completed NCT00066209
14 Contamination During Removal of Two Different Personal Protective Systems Completed NCT00150475
15 Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome Completed NCT00173459
16 Collection of Convalescent SARS Plasma by Apheresis Completed NCT00342524
17 Seroprevalence of MERS-CoV IgG in Healthcare Workers Completed NCT02497885
18 Clinical Study of SARS in Children Completed NCT00173576
19 Respiratory Virus Outpatient Study (FLU 002 Plus) Completed NCT01056354
20 Collection and Testing of Respiratory Samples Completed NCT01302418
21 Long-term Assessment of Organ Functions Among Survivors of Severe Acute Respiratory Syndrome Recruiting NCT03443102
22 Respiratory Virus Hospitalization Study (FLU 003 Plus) Recruiting NCT01056185
23 A Clinical Cohort Study of Pneumonia in Respiratory Intensive Care Unit Recruiting NCT02738645
24 Detect Novel Pathogens and Characterize Emerging Infections Recruiting NCT01979705
25 Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases Recruiting NCT01200953
26 Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure Recruiting NCT03225807
27 The Respiratory Protection Effectiveness Clinical Trial Active, not recruiting NCT01249625
28 Collection of Plasma From People Who Recovered From or Were Vaccinated to Emerging Infectious Diseases Enrolling by invitation NCT02338986
29 Evaluation and Treatment of Severe Acute Respiratory Syndrome (SARS) Withdrawn NCT00073086
30 The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes Withdrawn NCT00172263
31 SARS Survivor Evaluations Withdrawn NCT00523276

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Cochrane evidence based reviews: severe acute respiratory syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

Anatomical Context for Severe Acute Respiratory Syndrome

The Foundational Model of Anatomy Ontology organs/tissues related to Severe Acute Respiratory Syndrome:

18
Respiratory Tract

MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

38
Lung, Testes, Monocytes, T Cells, Liver, Thyroid, Kidney

Publications for Severe Acute Respiratory Syndrome

Articles related to Severe Acute Respiratory Syndrome:

(show top 50) (show all 643)
# Title Authors Year
1
Correction to: Simultaneous detection of severe acute respiratory syndrome, Middle East respiratory syndrome, and related bat coronaviruses by real-time reverse transcription PCR. ( 29273879 )
2018
2
Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3. ( 29294448 )
2018
3
The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-I^ antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation. ( 28591694 )
2017
4
The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. ( 28148787 )
2017
5
Simultaneous detection of severe acute respiratory syndrome, Middle East respiratory syndrome, and related bat coronaviruses by real-time reverse transcription PCR. ( 28220326 )
2017
6
Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection. ( 28373583 )
2017
7
Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies. ( 29143192 )
2017
8
Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection. ( 28404843 )
2017
9
Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome). ( 28159163 )
2017
10
Comprehensive structural analysis of designed incomplete polypeptide chains of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus. ( 28750053 )
2017
11
No. 225-Management Guidelines for Obstetric Patients and Neonates Born to Mothers With Suspected or Probable Severe Acute Respiratory Syndrome (SARS). ( 28729104 )
2017
12
A 12-year follow-up study of combined treatment of post-severe acute respiratory syndrome patients with femoral head necrosis. ( 29089773 )
2017
13
Middle East respiratory syndrome and severe acute respiratory syndrome. ( 26855039 )
2016
14
Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats. ( 27213718 )
2016
15
Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel. ( 26930074 )
2016
16
The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. ( 27965448 )
2016
17
Emerging infectious diseases: Focus on infection control issues for novel coronaviruses (Severe Acute Respiratory Syndrome-CoV and Middle East Respiratory Syndrome-CoV), hemorrhagic fever viruses (Lassa and Ebola), and highly pathogenic avian influenza viruses, A(H5N1) and A(H7N9). ( 27131142 )
2016
18
Modelling input-output flows of severe acute respiratory syndrome in mainland China. ( 26924026 )
2016
19
Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS). ( 27501327 )
2016
20
Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion. ( 27466418 )
2016
21
The contribution of the cytoplasmic retrieval signal of severe acute respiratory syndrome coronavirus to intracellular accumulation of S proteins and incorporation of S protein into virus-like particles. ( 27145752 )
2016
22
Qualitative study on the shifting sociocultural meanings of the facemask in Hong Kong since the severe acute respiratory syndrome (SARS) outbreak: implications for infection control in the post-SARS era. ( 27145823 )
2016
23
Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). ( 26953343 )
2016
24
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. ( 27170748 )
2016
25
An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy. ( 26878082 )
2016
26
Detection of the Severe Acute Respiratory Syndrome-Related Coronavirus and Alphacoronavirus in the Bat Population of Taiwan. ( 27178103 )
2016
27
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism. ( 26861016 )
2016
28
Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step. ( 25552710 )
2015
29
Severe acute respiratory syndrome coronaviruses with mutations in the e protein are attenuated and promising vaccine candidates. ( 25609816 )
2015
30
Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection. ( 25818534 )
2015
31
Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2. ( 25348530 )
2015
32
Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques. ( 26647718 )
2015
33
Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. ( 26719272 )
2015
34
Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology. ( 25520500 )
2015
35
Brief Report: Incubation Period Duration and Severity of Clinical Disease Following Severe Acute Respiratory Syndrome Coronavirus Infection. ( 26133021 )
2015
36
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins. ( 26041291 )
2015
37
Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference. ( 26378163 )
2015
38
Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism. ( 26320399 )
2015
39
Controlling Middle East Respiratory Syndrome: Lessons Learned From Severe Acute Respiratory Syndrome. ( 26240205 )
2015
40
Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor. ( 25907116 )
2015
41
ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus. ( 26433221 )
2015
42
New coronavirus outbreak. Lessons learned from the severe acute respiratory syndrome epidemic. ( 25591619 )
2015
43
Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. ( 26015500 )
2015
44
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. ( 26392224 )
2015
45
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome. ( 26331680 )
2015
46
Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination. ( 26269185 )
2015
47
Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection. ( 25056892 )
2014
48
Effects of Toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine. ( 24850731 )
2014
49
Comparative analysis of the activation of unfolded protein response by spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus HKU1. ( 24410900 )
2014
50
Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus. ( 24885320 )
2014

Variations for Severe Acute Respiratory Syndrome

Expression for Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for Severe Acute Respiratory Syndrome

Pathways related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CCL2 CCL5 CD209 CD40LG CTSL CXCL10
2
Show member pathways
13.66 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
3
Show member pathways
13.54 CCL2 CCL5 CXCL8 IFNA1 IFNB1 IFNG
4
Show member pathways
13.4 CCL2 CCL5 CD40LG CXCL10 CXCL8 STAT1
5
Show member pathways
13.28 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
6
Show member pathways
12.93 CCL2 CCL5 CD209 CXCL8 IFNA1 IFNB1
7
Show member pathways
12.86 CCL2 CCL5 CXCL10 CXCL8 STAT1
8
Show member pathways
12.86 CD40LG CTSL CXCL8 IFNA1 IFNG STAT1
9
Show member pathways
12.75 CCL5 CXCL10 CXCL8 IFNA1 IFNB1 IFNG
10
Show member pathways
12.58 CXCL8 IFNA1 IFNB1 IRF3 STAT1 TNF
11
Show member pathways
12.56 IFNA1 IFNB1 IFNG IRF3 STAT1
12
Show member pathways
12.5 IFNA1 IFNB1 IFNG TNF
13
Show member pathways
12.37 IFNA1 IFNB1 IFNG STAT1
14
Show member pathways
12.36 CCL2 CXCL10 CXCL8 IFNG TNF
15
Show member pathways
12.34 CCL2 CCL5 IFNG TNF
16 12.32 CCL2 CCL5 CD40LG CXCL10 IFNA1 IFNG
17
Show member pathways
12.31 IFNA1 IFNB1 IFNG STAT1
18
Show member pathways
12.29 CXCL8 IFNG IRF3 STAT1 TNF
19
Show member pathways
12.27 CXCL8 IFNB1 IRF3 TNF
20
Show member pathways
12.26 CD40LG IFNG STAT1 TNF
21
Show member pathways
12.26 IFNA1 IFNB1 IFNG STAT1 TNF
22 12.17 CD209 CLEC4M IFNA1 IFNB1 IFNG STAT1
23
Show member pathways
12.14 CCL2 CCL5 CXCL10 CXCL8 IFNA1 IFNB1
24
Show member pathways
12.13 CCL2 CCL5 CD209 CLEC4M CXCL10 CXCL8
25 12.12 CCL2 CTSL IFNG TNF
26 12.12 CXCL8 IFNA1 IFNB1 IRF3 STAT1 TNF
27
Show member pathways
12.08 CTSL CXCL10 CXCL8 IFNB1 IFNG STAT1
28 12.07 IFNB1 IFNG STAT1 TNF
29 12.04 CCL2 CXCL10 CXCL8 IFNG TNF
30
Show member pathways
12.02 CCL2 CCL5 CXCL10 CXCL8
31
Show member pathways
12.01 CXCL8 IFNA1 IFNB1 IFNG IRF3 STAT1
32 12 CCL2 CXCL8 STAT1 TNF
33 11.98 CCL2 CCL5 CXCL10 TNF
34 11.93 CCL2 CXCL8 STAT1 TNF
35 11.92 CXCL8 IFNB1 IFNG
36
Show member pathways
11.91 IFNG STAT1 TNF
37 11.89 IFNA1 IFNB1 IFNG STAT1
38 11.87 CXCL8 IFNG TNF
39 11.87 CD40LG CXCL8 TNF
40 11.84 CCL2 CCL5 CTSL CXCL8 IFNG TNF
41
Show member pathways
11.81 CD40LG CXCL8 IFNG TNF
42 11.79 CXCL8 IFNG STAT1
43 11.79 CD209 IFNB1 IFNG TNF
44 11.76 CXCL8 IRF3 TNF
45 11.71 CCL2 CCL5 CXCL8 TNF
46
Show member pathways
11.71 CD40LG CXCL8 IFNG TNF
47 11.63 IFNG STAT1 TNF
48 11.58 CCL2 CCL5 CXCL10 CXCL8 TNF
49 11.57 CCL2 CD40LG CXCL8 IFNG TNF
50 11.54 CCL2 IFNG TNF

GO Terms for Severe Acute Respiratory Syndrome

Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ACE2 CCL2 CCL5 CD40LG CTRL CTSL
2 extracellular region GO:0005576 9.47 ACE2 CCL2 CCL5 CD209 CD40LG CLEC4M
3 external side of plasma membrane GO:0009897 9.46 CD209 CD40LG CXCL10 TNF

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNG
2 adaptive immune response GO:0002250 9.95 CD209 CLEC4M CTSL IFNA1 IFNG
3 chemotaxis GO:0006935 9.94 CCL2 CCL5 CXCL10 CXCL8
4 cellular response to interferon-gamma GO:0071346 9.88 CCL2 CCL5 STAT1
5 viral entry into host cell GO:0046718 9.87 ACE2 CD209 CLEC4M
6 cellular response to interleukin-1 GO:0071347 9.86 CCL2 CCL5 CXCL8
7 cell chemotaxis GO:0060326 9.86 CCL2 CCL5 CXCL10
8 interferon-gamma-mediated signaling pathway GO:0060333 9.86 IFNG IRF3 STAT1
9 regulation of insulin secretion GO:0050796 9.85 CCL5 IFNG TNF
10 B cell differentiation GO:0030183 9.85 CD40LG IFNA1 IFNB1
11 neutrophil chemotaxis GO:0030593 9.85 CCL2 CCL5 CXCL8
12 defense response GO:0006952 9.85 CXCL10 CXCL8 IFNA1 IFNB1 TNF
13 positive regulation of T cell proliferation GO:0042102 9.84 CCL5 CD209 CD40LG
14 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 CCL5 STAT1 TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 CCL5 STAT1 TNF
16 protein kinase B signaling GO:0043491 9.82 CCL2 CCL5 TNF
17 antigen processing and presentation GO:0019882 9.81 CD209 CLEC4M CTSL
18 negative regulation of viral genome replication GO:0045071 9.81 CCL5 IFNB1 TNF
19 chemokine-mediated signaling pathway GO:0070098 9.81 CCL2 CCL5 CXCL10 CXCL8
20 cellular response to lipopolysaccharide GO:0071222 9.8 CCL2 CXCL10 CXCL8 IRF3 TNF
21 response to exogenous dsRNA GO:0043330 9.78 IFNA1 IFNB1 IRF3
22 type I interferon signaling pathway GO:0060337 9.78 IFNA1 IFNB1 IRF3 STAT1
23 B cell proliferation GO:0042100 9.77 CD40LG IFNA1 IFNB1
24 cellular response to fibroblast growth factor stimulus GO:0044344 9.77 CCL2 CCL5 CXCL8
25 response to virus GO:0009615 9.77 CCL5 CXCL10 IFNB1 IFNG TNF
26 regulation of type I interferon-mediated signaling pathway GO:0060338 9.76 IFNA1 IFNB1 STAT1
27 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.73 IFNA1 IFNB1 IFNG
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG TNF
29 cellular response to interferon-beta GO:0035458 9.72 IFNB1 STAT1
30 positive regulation of T cell migration GO:2000406 9.71 CCL5 CXCL10
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 STAT1
32 macrophage chemotaxis GO:0048246 9.71 CCL2 CCL5
33 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG STAT1
34 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
35 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.7 CCL5 CXCL8
36 positive regulation of interferon-alpha production GO:0032727 9.7 IRF3 STAT1
37 neutrophil activation GO:0042119 9.69 CCL5 CXCL8
38 modulation by virus of host morphology or physiology GO:0019048 9.67 CD209 CLEC4M
39 viral genome replication GO:0019079 9.67 CCL2 CD209 CLEC4M
40 cell-cell recognition GO:0009988 9.65 CD209 CLEC4M
41 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
42 receptor biosynthetic process GO:0032800 9.63 ACE2 TNF
43 defense response to virus GO:0051607 9.63 CXCL10 IFNA1 IFNB1 IFNG IRF3 STAT1
44 virion attachment to host cell GO:0019062 9.62 CD209 CLEC4M
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IFNG TNF
46 lipopolysaccharide-mediated signaling pathway GO:0031663 9.62 CCL2 CCL5 IRF3 TNF
47 peptide antigen transport GO:0046968 9.61 CD209 CLEC4M
48 positive regulation of vitamin D biosynthetic process GO:0060557 9.58 IFNG TNF
49 macrophage apoptotic process GO:0071888 9.57 CTSL IRF3
50 leukocyte cell-cell adhesion GO:0007159 9.56 CCL5 CD209 CD40LG CLEC4M

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.54 ACE2 CD209 CLEC4M
2 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG STAT1 TNF
3 virion binding GO:0046790 9.32 CD209 CLEC4M
4 cytokine activity GO:0005125 9.28 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
5 CCR5 chemokine receptor binding GO:0031730 9.26 CCL5 STAT1
6 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL8

Sources for Severe Acute Respiratory Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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