SARS
MCID: SVR001
MIFTS: 58

Severe Acute Respiratory Syndrome (SARS) malady

Respiratory diseases, Infectious diseases categories

Summaries for Severe Acute Respiratory Syndrome

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in respiratory tract, has material basis in sars coronavirus (sars-cov), which is transmitted by droplet spread of respiratory secretions, transmitted by ingestion of contaminated food, or transmitted by fomites. the infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards: Severe Acute Respiratory Syndrome, also known as SARS, is related to influenza and hepatitis, and has symptoms including hypoxia, dry cough and body aches. An important gene associated with Severe Acute Respiratory Syndrome is CLEC4M (C-type lectin domain family 4, member M), and among its related pathways is Influenza A. The compounds 2,5-oligoadenylate and rantes have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and t cells.

CDC:3 Remembering the 2003 global SARS outbreak...More

Wikipedia:63 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Aliases & Classifications for Severe Acute Respiratory Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

severe acute respiratory syndrome 8 42 10 48 60
sars 8 42 48
sars-associated coronavirus 48
sars-cov infection 8
sars-cov 48


External Ids:

Disease Ontology8 DOID:2945
MeSH34 D045169
NCIt39 C85064
ICD9CM27 079.82
MESH via Orphanet35 D045169
SNOMED-CT56 398447004
SNOMED-CT via Orphanet57 398447004
UMLS via Orphanet61 C1175175
ICD10 via Orphanet26 U04.9
ICD1025 U04

Related Diseases for Severe Acute Respiratory Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to severe acute respiratory syndrome

Clinical Features for Severe Acute Respiratory Syndrome

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8Disease Ontology
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Symptoms:

8
  • hypoxia
  • dry cough
  • body aches
  • headache
  • fever

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Severe Acute Respiratory Syndrome

Drug clinical trials:

Search ClinicalTrials for Severe Acute Respiratory Syndrome

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Search CenterWatch for Severe Acute Respiratory Syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

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Anatomical Context for Severe Acute Respiratory Syndrome

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

32
Lung, T cells, Testes, Kidney, Thyroid, Liver, Placenta, Skin, Salivary gland, B cells, Brain, Spleen, Bone

FMA organs/tissues related to Severe Acute Respiratory Syndrome:

14
Respiratory tract

Animal Models for Severe Acute Respiratory Syndrome or affiliated genes

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Publications for Severe Acute Respiratory Syndrome

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50PubMed
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Articles related to Severe Acute Respiratory Syndrome:

(show top 50)    (show all 598)
idTitleAuthorsYear
1
Severe Acute Respiratory Syndrome Beyond Amoy Gardens: Completing the Incomplete Legacy. (24319085)
2013
2
Acute respiratory distress syndrome in one patient with gout complicated by severe pulmonary tuberculosis: report of one case and literature review. (23585958)
2013
3
Severe acute respiratory syndrome (SARS) and the rhetorical construction of "bad" scientific work. (22586846)
2012
4
Potential cross-reactivity of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid (N)-based IgG ELISA assay for plasma samples from HIV-1 positive intravenous drug users (IDUs). (22983073)
2012
5
Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection. (23015710)
2012
6
The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis. (23202509)
2012
7
Phosphatidylinositol 4-kinase IIII^ is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry. (22253445)
2012
8
Follow up of aerobic capacity in children affected by severe acute respiratory syndrome. (22212464)
2012
9
Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread. (22956738)
2012
10
Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope. (21813600)
2011
11
A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge. (21937658)
2011
12
Integrity of the early secretory pathway promotes, but is not required for, severe acute respiratory syndrome coronavirus RNA synthesis and virus-induced remodeling of endoplasmic reticulum membranes. (19889777)
2010
13
Osteonecrosis in patients after severe acute respiratory syndrome (SARS): possible role of anticardiolipin antibodies. (20216125)
2010
14
Annexin A2 on lung epithelial cell surface is recognized by severe acute respiratory syndrome-associated coronavirus spike domain 2 antibodies. (20015551)
2010
15
Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection. (20462354)
2010
16
Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide. (19439480)
2009
17
Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein. (19403678)
2009
18
Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus. (18792806)
2008
19
Responses of Chinese elderly to the threat of severe acute respiratory syndrome (SARS) in a Canadian community. (18173586)
2008
20
Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium. (18094188)
2008
21
Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway. (17942557)
2008
22
Pathology and pathogenesis of severe acute respiratory syndrome. (17392154)
2007
23
Preparations and limitations for prevention of severe acute respiratory syndrome in a tertiary care centre of India. (17512634)
2007
24
Amino acid substitutions in the s2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells. (17652383)
2007
25
Type IVB pilus operon promoter controlling expression of the severe acute respiratory syndrome-associated coronavirus nucleocapsid gene in Salmonella enterica Serovar Typhi elicits full immune response by intranasal vaccination. (17596427)
2007
26
Severe acute respiratory syndrome coronavirus infection in vaccinated ferrets. (17922397)
2007
27
Quantitative temporal-spatial distribution of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) in post-mortem tissues. (17607787)
2007
28
Recombinant protein-based assays for detection of antibodies to severe acute respiratory syndrome coronavirus spike and nucleocapsid proteins. (17229882)
2007
29
Open reading frame 8a of the human severe acute respiratory syndrome coronavirus not only promotes viral replication but also induces apoptosis. (17597455)
2007
30
The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2. (17631932)
2007
31
Changes in attitudes toward wildlife and wildlife meats in Hunan Province, central China, before and after the severe acute respiratory syndrome outbreak. (21396016)
2007
32
Lipid rafts play an important role in the early stage of severe acute respiratory syndrome-coronavirus life cycle. (17194611)
2007
33
Severe acute respiratory syndrome coronavirus gene 7 products contribute to virus-induced apoptosis. (17686858)
2007
34
Optimizing severe acute respiratory syndrome response strategies: lessons learned from quarantine. (17413071)
2007
35
Therapeutic and prophylactic potential of small interfering RNAs against severe acute respiratory syndrome: progress to date. (17263585)
2007
36
Severe acute respiratory syndrome--retrospect and lessons of 2004 outbreak in China. (17319269)
2006
37
Identifying epitopes responsible for neutralizing antibody and DC-SIGN binding on the spike glycoprotein of the severe acute respiratory syndrome coronavirus. (17041212)
2006
38
The impact of severe acute respiratory syndrome on the use of and requirements for filters in Canada. (16828696)
2006
39
Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS). (16182592)
2006
40
Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals. (16804033)
2006
41
The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome. (16672072)
2006
42
The structure of the endoribonuclease XendoU: From small nucleolar RNA processing to severe acute respiratory syndrome coronavirus replication. (16895992)
2006
43
Prevalence of subclinical infection and transmission of severe acute respiratory syndrome (SARS) in a residential care home for the elderly. (16760548)
2006
44
Investigation of the influencing factors on severe acute respiratory syndrome among health care workers. (16778970)
2006
45
Risk-stratified seroprevalence of severe acute respiratory syndrome coronavirus among children in Hong Kong. (16682490)
2006
46
Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. (15897467)
2005
47
Altered p38 mitogen-activated protein kinase expression in different leukocytes with increment of immunosuppressive mediators in patients with severe acute respiratory syndrome. (15187168)
2004
48
Late-stage adult respiratory distress syndrome caused by severe acute respiratory syndrome: abnormal findings at thin-section CT. (14752179)
2004
49
Severe acute respiratory syndrome in a doctor working at the Prince of Wales Hospital. (12777657)
2003
50
G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome. (10853855)
2000

Genetic Variations for Severe Acute Respiratory Syndrome

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Expression for genes affiliated with Severe Acute Respiratory Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for genes affiliated with Severe Acute Respiratory Syndrome

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29KEGG
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Pathways related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5MX1, CXCL10, CLEC4M, MCRS1, CD209

Compounds for genes affiliated with Severe Acute Respiratory Syndrome

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
12,5-oligoadenylate4410.7MX1, CXCL10, IFNL1
2rantes4410.7ICAM3
3mannose4410.7ICAM3, JPH4, CD209, CLEC4M
4dexamethasone44 49 28 1113.6ICAM3, SAA4, CD209, CXCL10, CXCL9, SULT1A3
5ifn-alpha4410.6MX1, CXCL9, CXCL10
6carbohydrates4410.5CLEC4M, CD209, ICAM3
7neopterin4410.5SAA4, CXCL10, MX1
8allergens4410.4CXCL10, CLEC4M, CD209
9calcium44 49 11 2413.3ICAM3, SAA4, CTRL, CD209, MCRS1, CLEC4M

GO Terms for genes affiliated with Severe Acute Respiratory Syndrome

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16Gene Ontology
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Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5ACE2, CXCL9, CXCL10, CLEC4M, CD209, SAA4

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1viral attachment to host cellGO:01906210.7CLEC4M, CD209
2intracellular virion transportGO:04679510.7CLEC4M, CD209
3peptide antigen transportGO:04696810.6CLEC4M, CD209
4defense response to virusGO:05160710.6IFNL1, CXCL10, CXCL9, MX1
5cell-cell recognitionGO:00998810.5CLEC4M, CD209
6leukocyte cell-cell adhesionGO:00715910.5CLEC4M, CD209
7viral genome replicationGO:01907910.4CD209, CLEC4M
8antigen processing and presentationGO:01988210.2CLEC4M, CD209

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:03024610.5CLEC4M, CLEC4G, CD209
2virion bindingGO:04679010.4CLEC4M, CD209
3mannose bindingGO:00553710.2CLEC4M, CD209

Products for genes affiliated with Severe Acute Respiratory Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Severe Acute Respiratory Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet