SARS
MCID: SVR001
MIFTS: 54

Severe Acute Respiratory Syndrome (SARS) malady

Respiratory, Infectious categories

Summaries for Severe Acute Respiratory Syndrome

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in respiratory tract, has material basis in sars coronavirus (sars-cov), which is transmitted by droplet spread of respiratory secretions, transmitted by ingestion of contaminated food, or transmitted by fomites. the infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards: Severe Acute Respiratory Syndrome, also known as SARS, is related to hepatitis c and hepatitis b, and has symptoms including fever, headache and body aches. An important gene associated with Severe Acute Respiratory Syndrome is CLEC4M (C-type lectin domain family 4, member M), and among its related pathways is Influenza A. The compounds 2,5-oligoadenylate and rantes have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, skin and liver.

CDC:3 Remembering the 2003 global SARS outbreak...More

Wikipedia:64 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Aliases & Classifications for Severe Acute Respiratory Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Respiratory


Aliases & Descriptions:

severe acute respiratory syndrome 8 43 10 49 61
sars 8 43 49
sars-associated coronavirus 49
sars-cov infection 8
sars-cov 49


External Ids:

Disease Ontology8 DOID:2945
MeSH35 D045169
NCIt40 C85064
ICD9CM27 079.82
MESH via Orphanet36 D045169
SNOMED-CT57 398447004
ICD10 via Orphanet26 U04
SNOMED-CT via Orphanet58 398447004
UMLS via Orphanet62 C1175175
ICD1025 U04

Related Diseases for Severe Acute Respiratory Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to severe acute respiratory syndrome

Clinical Features for Severe Acute Respiratory Syndrome

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 5)
  • fever
  • headache
  • body aches
  • dry cough
  • hypoxia

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Severe Acute Respiratory Syndrome

Drug clinical trials:

Search ClinicalTrials for Severe Acute Respiratory Syndrome

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Search CenterWatch for Severe Acute Respiratory Syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

Anatomical Context for Severe Acute Respiratory Syndrome

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

33
Skin, Liver, Brain, Kidney, Lung, Spleen, Whole blood, Thyroid, Salivary gland, Placenta, Monocytes, T cells, B cells, Bronchial epithelium

FMA organs/tissues related to Severe Acute Respiratory Syndrome:

14
Respiratory tract

Animal Models for Severe Acute Respiratory Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Severe Acute Respiratory Syndrome

Sources:
51PubMed
See all sources

Articles related to Severe Acute Respiratory Syndrome:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Acute respiratory distress syndrome with refractory hypoxaemia and severe septic shock caused by melioidosis: successful treatment with veno-venous extracorporeal membrane oxygenation. (23530796)
2013
2
OPV-like poliovirus type 1 detection in patients with severe acute respiratory syndrome. (22371233)
2012
3
Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation. (23035226)
2012
4
Diagnostics of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid antigen using chicken immunoglobulin Y. (22334738)
2012
5
Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain. (22787216)
2012
6
Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus. (20980507)
2011
7
Quantitative proteomics analysis reveals BAG3 as a potential target to suppress severe acute respiratory syndrome coronavirus replication. (20392858)
2010
8
Lessons from the past: perspectives on severe acute respiratory syndrome. (20566545)
2010
9
Corticosteroids as adjunctive therapy in severe blastomycosis-induced acute respiratory distress syndrome in an immunosuppressed patient. (20507238)
2010
10
The N-terminal region of severe acute respiratory syndrome coronavirus protein 6 induces membrane rearrangement and enhances virus replication. (20106914)
2010
11
Singapore's response to the severe acute respiratory syndrome outbreak: what do Singapore physicians think? (19960223)
2010
12
Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. (19864379)
2010
13
Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain. (19324051)
2009
14
A test of syndromic surveillance using a severe acute respiratory syndrome model. (19555611)
2009
15
Translational control of the subgenomic RNAs of severe acute respiratory syndrome coronavirus. (19363699)
2009
16
SOGC Clinical Practice Guideline. Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS). No. 225, April 2009. (19780222)
2009
17
Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3. (19828617)
2009
18
Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. (19258635)
2009
19
Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication. (19106108)
2009
20
Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection. (18697825)
2008
21
Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism. (18448520)
2008
22
Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation. (18632968)
2008
23
Co-infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice. (18380809)
2008
24
Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS. (17331558)
2007
25
Human immunodeficiency viral vector pseudotyped with the spike envelope of severe acute respiratory syndrome coronavirus transduces human airway epithelial cells and dendritic cells. (17518614)
2007
26
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. (17596301)
2007
27
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters. (17381079)
2007
28
The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese. (17540042)
2007
29
Knowledge of and attitudes toward severe acute respiratory syndrome among a cohort of dental patients in Hong Kong following a major local outbreak. (17405470)
2007
30
Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice. (17276898)
2007
31
Evidence for quasi species in severe acute respiratory syndrome-associated coronavirus deletion mutants. (17230423)
2007
32
The 29-nucleotide deletion present in human but not in animal severe acute respiratory syndrome coronaviruses disrupts the functional expression of open reading frame 8. (17928347)
2007
33
Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists. (17108024)
2007
34
Recombinant truncated nucleocapsid protein as antigen in a novel immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of severe acute respiratory syndrome coronavirus infection. (17202310)
2007
35
Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. (16581910)
2006
36
The possible mechanism of lung injury induced by severe acute respiratory syndrome coronavirus spike glycoprotein]. (17129463)
2006
37
Generating vesicular stomatitis virus pseudotype bearing the severe acute respiratory syndrome coronavirus spike envelope glycoprotein for rapid and safe neutralization test or cell-entry assay. (17135519)
2006
38
Immunization of mice with a DNA vaccine based on severe acute respiratory syndrome coronavirus spike protein fragment 1. (16987069)
2006
39
Spatial dynamics of an epidemic of severe acute respiratory syndrome in an urban area. (17242832)
2006
40
Radiology of severe acute respiratory syndrome (SARS): the emerging pathologic-radiologic correlates of an emerging disease. (17110851)
2006
41
Risk of severe acute respiratory syndrome-associated coronavirus transmission aboard commercial aircraft. (16987125)
2006
42
Human neutralizing Fab molecules against severe acute respiratory syndrome coronavirus generated by phage display. (16893997)
2006
43
Serum neopterin for early assessment of severity of severe acute respiratory syndrome. (15925828)
2005
44
Can routine laboratory tests discriminate between severe acute respiratory syndrome and other causes of community-acquired pneumonia? (15791504)
2005
45
Emerging infections and pregnancy: West Nile virus, monkeypox, severe acute respiratory syndrome, and bioterrorism. (16085032)
2005
46
Impact of severe acute respiratory syndrome on patient access to palliative radiation therapy. (18628197)
2005
47
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. (15496474)
2004
48
Severe acute respiratory syndrome in Taiwan: analysis of epidemiological characteristics in 29 cases. (14667789)
2004
49
Surgical treatment of tracheoesophageal fistula in a patient with severe acute respiratory syndrome complicated with extensive pulmonary fibrosis. (15624043)
2004
50
Determination of serum acute phase reaction protein in patients with severe acute respiratory syndrome]. (15061914)
2004

Genetic Variations for Severe Acute Respiratory Syndrome

Expression for genes affiliated with Severe Acute Respiratory Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for genes affiliated with Severe Acute Respiratory Syndrome

Sources:
30KEGG
See all sources

Pathways related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5MX1, CXCL10, CLEC4M, MCRS1, CD209

Compounds for genes affiliated with Severe Acute Respiratory Syndrome

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
12,5-oligoadenylate4510.7MX1, CXCL10, IFNL1
2rantes4510.7ICAM3
3mannose4510.7ICAM3, CD209, CLEC4M, JPH4
4dexamethasone45 50 29 1113.6ICAM3, SAA4, CD209, CXCL10, CXCL9, SULT1A3
5ifn-alpha4510.6MX1, CXCL9, CXCL10
6carbohydrates4510.5ICAM3, CD209, CLEC4M
7neopterin4510.5MX1, CXCL10, SAA4
8allergens4510.4CD209, CLEC4M, CXCL10
9calcium45 50 11 2413.3SAA4, CXCL9, CXCL10, CLEC4M, MCRS1, CD209

GO Terms for genes affiliated with Severe Acute Respiratory Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.5ACE2, CXCL9, CXCL10, CLEC4M, CD209, SAA4

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1viral attachment to host cellGO:01906210.7CLEC4M, CD209
2intracellular virion transportGO:04679510.7CLEC4M, CD209
3peptide antigen transportGO:04696810.6CLEC4M, CD209
4defense response to virusGO:05160710.6IFNL1, CXCL10, CXCL9, MX1
5cell-cell recognitionGO:00998810.5CLEC4M, CD209
6leukocyte cell-cell adhesionGO:00715910.5CLEC4M, CD209
7viral genome replicationGO:01907910.4CD209, CLEC4M
8antigen processing and presentationGO:01988210.2CLEC4M, CD209

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:03024610.5CLEC4M, CLEC4G, CD209
2virion bindingGO:04679010.4CLEC4M, CD209
3mannose bindingGO:00553710.2CLEC4M, CD209

Products for genes affiliated with Severe Acute Respiratory Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Severe Acute Respiratory Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet