MCID: SVR001
MIFTS: 50

Severe Acute Respiratory Syndrome malady

Rare diseases, Respiratory diseases, Infectious diseases, Fetal diseases categories

Aliases & Classifications for Severe Acute Respiratory Syndrome

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 3CDC, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Severe Acute Respiratory Syndrome, Aliases & Descriptions:

Name: Severe Acute Respiratory Syndrome 9 41 11 47 3 60
Sars 9 41 47 3
Sars-Associated Coronavirus 47
 
Sars-Cov Infection 9
Sars-Cov 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
severe acute respiratory syndrome:
Age of onset: All ages


External Ids:

Disease Ontology9 DOID:2945
NCIt38 C85064
MeSH33 D045169
ICD9CM27 079.82
Orphanet47 140896
SNOMED-CT55 398447004
MESH via Orphanet34 D045169
ICD10 via Orphanet26 U04.9
UMLS via Orphanet61 C1175175
ICD1025 U04

Summaries for Severe Acute Respiratory Syndrome

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Disease Ontology:9 A viral infectious disease that results in infection located in respiratory tract, has material basis in sars coronavirus (sars-cov), which is transmitted by droplet spread of respiratory secretions, transmitted by ingestion of contaminated food, or transmitted by fomites. the infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards based summary: Severe Acute Respiratory Syndrome, also known as sars, is related to malaria and hepatitis c, and has symptoms including fever, headache and body aches. An important gene associated with Severe Acute Respiratory Syndrome is CLEC4M (C-type lectin domain family 4, member M), and among its related pathways are Protein digestion and absorption and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The compounds groalpha and pdtc have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and t cells, and related mouse phenotype homeostasis/metabolism.

CDC:3 Severe acute respiratory syndrome (SARS) is a viral respiratory illness caused by a coronavirus, called SARS-associated coronavirus (SARS-CoV). SARS was first reported in Asia in February 2003. The illness spread to more than two dozen countries in North America, South America, Europe, and Asia before the SARS global outbreak of 2003 was contained.

Wikipedia:63 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Related Diseases for Severe Acute Respiratory Syndrome

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Diseases in the Respiratory Failure family:

severe acute respiratory syndrome

Diseases related to Severe Acute Respiratory Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1malaria30.3FCER2
2hepatitis c30.2CLEC4M, CXCL10, CD209
3hiv-129.5FCER2, CLEC4M, CXCL10, CD209, CTRL
4asthma29.3CXCL5, CXCL10, FCER2
5influenza10.6
6hepatitis10.5
7pneumonia10.5
8avian influenza10.4
9newcastle disease10.4CXCL10
10osteonecrosis10.4
11acute respiratory distress syndrome10.4
12sarcosinemia10.3
13pulmonary function10.3
14adult respiratory distress syndrome10.3
15acute orbital inflammation10.3
16lymphopenia10.3
17thyroiditis10.3
18bronchiolitis10.2FCER2
19west nile virus10.1
20hepatitis c virus10.1
21pulmonary fibrosis10.1
22thrombocytopenia10.1
23parametritis10.1
24orchitis10.1
25neuronitis10.1
26viral pneumonia10.1
27nasopharyngitis10.1
28pulmonary edema10.1
29monkeypox10.1
30encephalitis10.1
31gastroenteritis10.1
32pneumothorax10.1
33stomatitis10.1
34tracheoesophageal fistula10.1
35spontaneous pneumothorax10.1
36autonomic dysfunction10.1
37fibromyalgia10.1
38alcohol abuse10.1
39actinic keratosis10.1
40diabetic macular edema10.1
41neurogenic bladder10.1
42keratosis10.1
43melanoma10.1
44dengue disease10.1CD209, SULT1A3
45cork-handlers' disease10.1CXCL10, CXCL5, ACE2
46acute pancreatitis10.0CXCL5, SULT1A3
47pulmonary fibrosis, idiopathic10.0CXCL5, CXCL10
48extrinsic allergic alveolitis10.0CXCL5, FCER2
49primary hyperoxaluria10.0SULT1A3, CXCL10, ACE2
50tuberculosis10.0CD209, CXCL10, CLEC4M

Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to severe acute respiratory syndrome

Symptoms for Severe Acute Respiratory Syndrome

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Symptoms:

 9
  • fever
  • headache
  • body aches
  • dry cough
  • hypoxia

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

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Drug clinical trials:

Search ClinicalTrials for Severe Acute Respiratory Syndrome

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

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Anatomical Context for Severe Acute Respiratory Syndrome

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MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

31
Lung, T cells, Testes, Kidney, Liver, Thyroid, Bone, Spleen, Brain, Salivary gland, Skin, Placenta, B cells

FMA organs/tissues related to Severe Acute Respiratory Syndrome:

14
Respiratory tract

Animal Models for Severe Acute Respiratory Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Severe Acute Respiratory Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0CD209, BCL2L2, ACE2, CXCL10, CLEC4M, FCER2

Publications for Severe Acute Respiratory Syndrome

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Articles related to Severe Acute Respiratory Syndrome:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase. (23536667)
2013
2
Severe acute respiratory syndrome (SARS) and the rhetorical construction of "bad" scientific work. (22586846)
2012
3
Potential cross-reactivity of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid (N)-based IgG ELISA assay for plasma samples from HIV-1 positive intravenous drug users (IDUs). (22983073)
2012
4
Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge. (22345460)
2012
5
OPV-like poliovirus type 1 detection in patients with severe acute respiratory syndrome. (22371233)
2012
6
Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein. (21524776)
2011
7
Quantitative proteomics analysis reveals BAG3 as a potential target to suppress severe acute respiratory syndrome coronavirus replication. (20392858)
2010
8
Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway. (20484496)
2010
9
The impact of epidemic outbreak: the case of severe acute respiratory syndrome (SARS) and suicide among older adults in Hong Kong. (20418214)
2010
10
The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated. (20409569)
2010
11
Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme. (19374142)
2009
12
Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome. (19570864)
2009
13
Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain. (19324051)
2009
14
Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15. (18045871)
2008
15
Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection. (18697825)
2008
16
siRNA silencing of angiotensin-converting enzyme 2 reduced severe acute respiratory syndrome-associated coronavirus replications in Vero E6 cells. (18449585)
2008
17
Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease. (17416434)
2008
18
A revisit on older adults suicides and Severe Acute Respiratory Syndrome (SARS) epidemic in Hong Kong. (18500689)
2008
19
Characterization of the prefusion and transition states of severe acute respiratory syndrome coronavirus S2-HR2. (18540634)
2008
20
Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. (18178835)
2008
21
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase. (18295820)
2008
22
Sensitive and specific enzyme-linked immunosorbent assay using chemiluminescence for detection of severe acute respiratory syndrome viral infection. (18032623)
2008
23
Investigation of the second wave (phase 2) of severe acute respiratory syndrome (SARS) in Toronto, Canada. What happened? (18404809)
2008
24
A test for constant fatality rate of an emerging epidemic: with applications to severe acute respiratory syndrome in Hong Kong and Beijing. (18047531)
2008
25
Human LINE1 endonuclease domain as a putative target of SARS-associated autoantibodies involved in the pathogenesis of severe acute respiratory syndrome. (18466680)
2008
26
Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. (17507479)
2007
27
Severe acute respiratory syndrome (SARS) coronavirus. (17458774)
2007
28
Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein. (17428862)
2007
29
Pathology and pathogenesis of severe acute respiratory syndrome. (17392154)
2007
30
Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS. (17331558)
2007
31
Induction of T-cell response by a DNA vaccine encoding a novel HLA-A*0201 severe acute respiratory syndrome coronavirus epitope. (17629360)
2007
32
The synergistic interaction of interferon types I and II leads to marked reduction in severe acute respiratory syndrome-associated coronavirus replication and increase in the expression of mRNAs for interferon-induced proteins. (17191018)
2007
33
Severe acute respiratory syndrome--retrospect and lessons of 2004 outbreak in China. (17319269)
2006
34
The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells. (16876844)
2006
35
Multicenter comparison of nucleic acid extraction methods for detection of severe acute respiratory syndrome coronavirus RNA in stool specimens. (16891478)
2006
36
Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. (16581910)
2006
37
Rewiring the severe acute respiratory syndrome coronavirus (SARS-CoV) transcription circuit: engineering a recombination-resistant genome. (16891412)
2006
38
The possible mechanism of lung injury induced by severe acute respiratory syndrome coronavirus spike glycoprotein]. (17129463)
2006
39
Severe acute respiratory syndrome coronavirus 7a accessory protein is a viral structural protein. (16840309)
2006
40
Knowledge of severe acute respiratory syndrome among community physicians, nurses, and emergency medical responders. (16892883)
2006
41
Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms. (16652313)
2006
42
Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells. (16684538)
2006
43
Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis. (15919935)
2005
44
Association of RANTES with the replication of severe acute respiratory syndrome coronavirus in THP-1 cells. (15851378)
2005
45
Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. (16195357)
2005
46
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. (15496474)
2004
47
Severe acute respiratory syndrome: clinical and laboratory manifestations. (18458712)
2004
48
Altered p38 mitogen-activated protein kinase expression in different leukocytes with increment of immunosuppressive mediators in patients with severe acute respiratory syndrome. (15187168)
2004
49
Late-stage adult respiratory distress syndrome caused by severe acute respiratory syndrome: abnormal findings at thin-section CT. (14752179)
2004
50
Clinical characteristics and mechanism of liver injury in patients with severe acute respiratory syndrome]. (12939186)
2003

Variations for Severe Acute Respiratory Syndrome

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Expression for genes affiliated with Severe Acute Respiratory Syndrome

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Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for genes affiliated with Severe Acute Respiratory Syndrome

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Compounds for genes affiliated with Severe Acute Respiratory Syndrome

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Compounds related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show all 21)
idCompoundScoreTop Affiliating Genes
1groalpha439.7CXCL5, CXCL10
2pdtc439.7CTRL, FCER2
3tarc439.6CXCL10, CXCL5
4ccl343 2810.6CXCL5, CXCL10
5ccl443 2810.5CXCL10, CXCL5
6galactose439.5CD209, CLEC4M, FCER2
7mannose439.5CD209, CLEC4M, FCER2
8histamine43 28 2411.5CTRL, CXCL10, FCER2
9neopterin439.3CXCL10, FCER2
10rantes439.3CXCL10, CXCL5, CD209
11leukotriene b443 59 2411.3FCER2, CXCL10, CXCL5
12fmlp439.3CTRL, CXCL5, FCER2
13genistein43 28 59 2 24 1214.2FCER2, SULT1A3, CXCL10, CTRL
14allergens439.2CD209, CXCL10, CLEC4M, FCER2
15pge2438.9CXCL5, CXCL10, FCER2
16superoxide43 249.8FCER2, CXCL5, ACE2, CTRL
17zinc43 249.7CTRL, ACE2, CXCL5, FCER2
18dexamethasone43 49 28 1211.5FCER2, SULT1A3, CXCL10, CXCL5, CD209
19tyrosine438.4FCER2, CXCL10, CXCL5, CD209, CTRL
20nitric oxide43 24 1210.4ACE2, CXCL5, CXCL10, SULT1A3, FCER2
21calcium43 49 24 1211.2FCER2, CLEC4M, CXCL10, CXCL5, CD209, CTRL

GO Terms for genes affiliated with Severe Acute Respiratory Syndrome

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Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.7CTRL, ACE2, CXCL5, CXCL10
2extracellular regionGO:00055768.0CD209, ACE2, CXCL5, CXCL10, CLEC4M

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1virion attachment to host cellGO:00190629.9CD209, CLEC4M
2peptide antigen transportGO:00469689.9CD209, CLEC4M
3cell-cell recognitionGO:00099889.9CD209, CLEC4M
4viral genome replicationGO:00190799.8CLEC4M, CD209
5modulation by virus of host morphology or physiologyGO:00190489.7CLEC4M, CD209
6antigen processing and presentationGO:00198829.7CD209, CLEC4M
7intracellular transport of virusGO:00757339.6CD209, CLEC4M
8leukocyte cell-cell adhesionGO:00071599.4CD209, CLEC4M

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1virion bindingGO:00467909.8CD209, CLEC4M
2mannose bindingGO:00055379.6CLEC4M, CD209
3chemokine activityGO:00080099.5CXCL5, CXCL10
4peptide antigen bindingGO:00426059.4CD209, CLEC4M
5carbohydrate bindingGO:00302469.2CD209, CLEC4M, FCER2

Products for genes affiliated with Severe Acute Respiratory Syndrome

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  • Antibodies
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  • Lysates
  • Antibodies
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  • Kits and Assays

Sources for Severe Acute Respiratory Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet