SARS
MCID: SVR001
MIFTS: 57

Severe Acute Respiratory Syndrome (SARS) malady

Categories: Rare diseases, Infectious diseases, Respiratory diseases, Fetal diseases

Aliases & Classifications for Severe Acute Respiratory Syndrome

Aliases & Descriptions for Severe Acute Respiratory Syndrome:

Name: Severe Acute Respiratory Syndrome 12 50 3 42 14 69
Sars 12 50 3
Sars-Cov Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2945
ICD10 33 J12.81 U04
ICD9CM 35 079.82
MeSH 42 D045169
NCIt 47 C85064
SNOMED-CT 64 398447004
UMLS 69 C1175175

Summaries for Severe Acute Respiratory Syndrome

Disease Ontology : 12 A viral infectious disease that results_in infection located in respiratory tract, has material basis in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has symptom fever, has symptom headache, has symptom body aches, has symptom dry cough, and has symptom hypoxia.

MalaCards based summary : Severe Acute Respiratory Syndrome, also known as sars, is related to nasopharyngitis and hepatitis c virus, and has symptoms including fever, headache and body aches. An important gene associated with Severe Acute Respiratory Syndrome is CLEC4M (C-Type Lectin Domain Family 4 Member M), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Acetaminophen and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related phenotype is immune system.

CDC : 3 Severe acute respiratory syndrome (SARS) is a viral respiratory illness caused by a coronavirus, called SARS-associated coronavirus (SARS-CoV). SARS was first reported in Asia in February 2003. The illness spread to more than two dozen countries in North America, South America, Europe, and Asia before the SARS global outbreak of 2003 was contained.

Wikipedia : 71 Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the... more...

Related Diseases for Severe Acute Respiratory Syndrome

Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Severe Acute Respiratory Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
id Related Disease Score Top Affiliating Genes
1 nasopharyngitis 29.5 CXCL8 IFNG TNF
2 hepatitis c virus 29.4 CD209 CLEC4M IFNA1 IRF3
3 epidemic typhus 11.2
4 sarcosinemia 11.2
5 acute respiratory coronavirus infection 10.2
6 anal atresia, hypospadias, and penoscrotal inversion 10.2 CCL2 CD209 IFNG
7 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.2 CCL5 TNF
8 choanal atresia, bilateral 10.2 CCL2 CXCL10 TNF
9 immunodeficiency due to a late component of complement deficiency 10.2 CXCL10 CXCL8 IFNG
10 ectothrix infectious disease 10.2 CXCL10 CXCL8 IFNG
11 steroid dehydrogenase deficiency dental anomalies 10.2 CCL2 CCL5 TNF
12 urethral intrinsic sphincter deficiency 10.2 CCL2 IFNG TNF
13 breast apocrine carcinoma in situ 10.2 CCL2 CCL5 CXCL8
14 cutaneous candidiasis 10.2 CCL2 CXCL8
15 abnormal retinal correspondence 10.2 CXCL10 IFNG TNF
16 benign exophthalmos syndrome 10.2 IFNA1 IFNB1
17 ulcerative proctitis 10.2 CCL2 CXCL8 TNF
18 osteodysplasty precocious of danks mayne and kozlowski 10.2 CCL5 IFNG TNF
19 central nervous system angiosarcoma 10.2 CXCL10 IFNA1 TNF
20 periodontosis 10.2 CXCL10 IFNG TNF
21 malignant neoplasm of acoustic nerve 10.1 CCL2 CXCL8 IFNG
22 plantar wart 10.1 CXCL8 IFNG TNF
23 esophagus lymphoma 10.1 CXCL8 IFNG TNF
24 choroiditis 10.1 CCL2 CXCL8 TNF
25 amyotrophic lateral sclerosis type 14 10.1 CXCL8 IFNG TNF
26 skin conditions 10.1 CCL2 CXCL8 TNF
27 parkinson disease 11 10.1 CXCL8 IFNG TNF
28 senile reticular retinal degeneration 10.1 CXCL8 IFNG TNF
29 infancy electroclinical syndrome 10.1 CCL2 CXCL8 TNF
30 mansonelliasis 10.1 CCL5 IFNG TNF
31 hydrops of gallbladder 10.1 CCL2 CCL5 STAT1
32 baritosis 10.1 CCL2 CXCL8 TNF
33 amelogenesis imperfecta 10.1 CCL2 CXCL8 TNF
34 bladder signet ring cell adenocarcinoma 10.1 CCL2 CCL5 CXCL10 TNF
35 burns 10.1 CXCL8 IFNG TNF
36 tracheitis 10.1 CXCL8 IFNG TNF
37 esophageal candidiasis 10.1 CCL2 CXCL10 IFNG TNF
38 balkan nephropathy 10.1 CXCL8 IFNG TNF
39 neovascular glaucoma 10.1 CCL2 CXCL8 TNF
40 pulpitis 10.1 CCL5 CXCL10 IFNG TNF
41 classic type lipoma 10.1 CXCL8 IFNG TNF
42 influenza 10.1
43 optic nerve hypoplasia 10.1 CCL2 CXCL8 TNF
44 blue toe syndrome 10.1 CXCL8 IFNG TNF
45 retinal ischemia 10.1 CCL2 CCL5 IFNG TNF
46 parasitic protozoa infectious disease 10.1 CXCL8 IFNG TNF
47 deafness, autosomal recessive 67 10.1 CCL2 CCL5 IFNG TNF
48 non-gestational choriocarcinoma 10.1 CCL5 IFNB1 IFNG
49 glucose intolerance 10.1 CCL2 CXCL8 IFNG TNF
50 strawberry gallbladder 10.1 CCL2 CXCL8 IFNG TNF

Graphical network of the top 20 diseases related to Severe Acute Respiratory Syndrome:



Diseases related to Severe Acute Respiratory Syndrome

Symptoms & Phenotypes for Severe Acute Respiratory Syndrome

Symptoms:

12
  • fever
  • headache
  • body aches
  • dry cough
  • hypoxia

UMLS symptoms related to Severe Acute Respiratory Syndrome:


coughing, fever, pruritus, snoring

MGI Mouse Phenotypes related to Severe Acute Respiratory Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 TMPRSS2 TNF ACE2 CCL2 CCL5 CD40LG

Drugs & Therapeutics for Severe Acute Respiratory Syndrome

Drugs for Severe Acute Respiratory Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 363)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Clonidine Approved Phase 4 4205-90-7 2803
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
5
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
6
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
7
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
8
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
9
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
10
Cilostazol Approved Phase 4 73963-72-1 2754
11
Ticlopidine Approved Phase 4 55142-85-3 5472
12
Montelukast Approved Phase 4 158966-92-8 5281040
13
Ticagrelor Approved Phase 4 274693-27-5 9871419
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
15
Lenograstim Approved Phase 4 135968-09-1
16
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
17
Cilastatin Approved Phase 4 82009-34-5 5280454 6435415
18
Imipenem Approved Phase 4 74431-23-5 104838
19
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
20
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
21
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
22
Butyric Acid Experimental Phase 4,Phase 3,Phase 2 107-92-6 264
23 Cisatracurium Phase 4
24 Neuromuscular Agents Phase 4,Phase 1,Phase 2
25 Neuromuscular Blocking Agents Phase 4,Phase 1,Phase 2
26 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Adjuvants, Anesthesia Phase 4
28 Analgesics Phase 4,Phase 3,Phase 2
29 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
30 Analgesics, Opioid Phase 4,Phase 3
31 Anesthetics Phase 4,Phase 3
32 Anesthetics, General Phase 4,Phase 3
33 Anesthetics, Intravenous Phase 4,Phase 3
34 Anesthetics, Local Phase 4
35 Antipyretics Phase 4,Phase 2
36 Central Nervous System Depressants Phase 4,Phase 3
37 Narcotics Phase 4,Phase 3
38 Nefopam Phase 4
39 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
40 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
41 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
42 Neuroprotective Agents Phase 4,Phase 2,Phase 3
43 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
44 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
47 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
49 Hormones Phase 4,Phase 2,Phase 3,Phase 1
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 300)
id Name Status NCT ID Phase
1 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4
2 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
3 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
4 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
5 Trial of Chinese Herbal Medicine in the Treatment of Upper Respiratory Tract Infections (URTIs) Completed NCT00887172 Phase 4
6 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
7 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4
8 Enteral Nutrition in Acute Pancreatitis Completed NCT01965873 Phase 4
9 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
10 ACCEL-LOADING-ACS Study Completed NCT01354808 Phase 4
11 Triple Versus Dual Antiplatelet Therapy in Patients Undergoing Coronary Stent Implantation Completed NCT00404716 Phase 4
12 Effects of Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention Completed NCT00404781 Phase 4
13 Effects of Intensive Antiplatelet Therapy for Patients With Clopidogrel Resistance After Coronary Stent Implantation Completed NCT01094457 Phase 4
14 Montelukast in Bronchiolitis Obliterans Syndrome Completed NCT01211509 Phase 4
15 Is Efficacy of PLAtelet Aggregation Inhibition by Ticagrelor Mediated P2Y12 Blockade Dependent Upon Endogenous Endothelial Nitric OXide? Completed NCT02169596 Phase 4
16 Adjunctive Cilostazol Versus High Maintenance-dose ClopidogrEL in Acute Myocardial Infarction (AMI) Patients According to CYP2C19 Polymorphism Completed NCT00915733 Phase 4
17 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4
18 Early Non-invasive Ventilation Outside the Intensive Care Unit Recruiting NCT01572337 Phase 4
19 G-CSF Plus NAC In Severe Alcoholic Hepatitis Recruiting NCT02971306 Phase 4
20 Imipenem Prophylaxis in Patients With Acute Pancreatitis Recruiting NCT02897206 Phase 4
21 Efficacy and Safety of Adjunctive Cilostazol in Acute Myocardial Infarction Patients Recruiting NCT01261832 Phase 4
22 Paediatric Ards Neuromuscular Blockade Study Not yet recruiting NCT02902055 Phase 4
23 Effect Of Early C-PAP Treatment For Sleep Apnea On Rehabilitation Of Stroke Patients Not yet recruiting NCT02426424 Phase 4
24 Steroids in Patients With Early ARDS Unknown status NCT00562835 Phase 2, Phase 3
25 Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea to Prevent Cardiovascular Disease Unknown status NCT00738179 Phase 3
26 Study of a Novel Technique of Mechanical Ventilation in Patients With Severe Acute Respiratory Failure Completed NCT00637507 Phase 2, Phase 3
27 Réa-MiniMax: Severe Acute Respiratory Failure in Hematology and Cancer Patients Without Bronchoalveolar Lavage Completed NCT00248443 Phase 3
28 Early Versus Delayed Enteral Feeding to Treat People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN Study) Completed NCT00883948 Phase 3
29 Lung Open Ventilation to Decrease Mortality in the Acute Respiratory Distress Syndrome Completed NCT00182195 Phase 3
30 Indiaclen Short Course Amoxycillin Therapy for Pneumonia With Wheeze Completed NCT00407394 Phase 3
31 Influenza Vaccination in Prevention From Acute Coronary Events in Coronary Artery Disease - FLUCAD Study Completed NCT00371098 Phase 2, Phase 3
32 Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis Completed NCT00608322 Phase 3
33 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
34 Treatment for Chronic Pain in Patients With Advanced Cancer Completed NCT00003687 Phase 3
35 Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder Completed NCT00755040 Phase 3
36 Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections Completed NCT00427076 Phase 3
37 MERS-CoV Infection tReated With A Combination of Lopinavir /Ritonavir and Interferon Beta-1b Recruiting NCT02845843 Phase 2, Phase 3
38 Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Patients Having Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT02622724 Phase 3
39 Liberal Oxygenation Versus Conservative Oxygenation in ARDS Recruiting NCT02713451 Phase 3
40 The MENDSII Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure Recruiting NCT01739933 Phase 3
41 Fluid Resuscitation in Acute Pancreatitis Recruiting NCT02709044 Phase 2, Phase 3
42 Age of Blood in Children in Pediatric Intensive Care Units Recruiting NCT01977547 Phase 3
43 Morphine in Moderate Obstructive Sleep Apnoea Recruiting NCT03127800 Phase 3
44 Bronchopulmonary Function in Response to Azithromycin Treatment for Chronic Lung Disease in HIV-infected Children Recruiting NCT02426112 Phase 3
45 Study of Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome (OHSS) in In Vito Fertilization Cycles and Derivation of OHSS Biomarkers Active, not recruiting NCT01535859 Phase 3
46 Therapeutic Anticoagulation Strategy for Acute Chest Syndrome Not yet recruiting NCT02580773 Phase 3
47 A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia Not yet recruiting NCT03006679 Phase 3
48 High Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome (ARDS) Terminated NCT01478802 Phase 2, Phase 3
49 Early Versus Delayed Enteral Feeding and Omega-3 Fatty Acid/Antioxidant Supplementation for Treating People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN-Omega Study) Terminated NCT00609180 Phase 3
50 The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial Terminated NCT01506401 Phase 3

Search NIH Clinical Center for Severe Acute Respiratory Syndrome

Cochrane evidence based reviews: severe acute respiratory syndrome

Genetic Tests for Severe Acute Respiratory Syndrome

Anatomical Context for Severe Acute Respiratory Syndrome

MalaCards organs/tissues related to Severe Acute Respiratory Syndrome:

39
Lung, T Cells, Testes, Bone, Liver, Kidney, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Severe Acute Respiratory Syndrome:

18
Respiratory Tract

Publications for Severe Acute Respiratory Syndrome

Articles related to Severe Acute Respiratory Syndrome:

(show top 50) (show all 634)
id Title Authors Year
1
The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. ( 28148787 )
2017
2
Middle East respiratory syndrome and severe acute respiratory syndrome. ( 26855039 )
2016
3
Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel. ( 26930074 )
2016
4
Modelling input-output flows of severe acute respiratory syndrome in mainland China. ( 26924026 )
2016
5
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism. ( 26861016 )
2016
6
The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection. ( 27965448 )
2016
7
An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy. ( 26878082 )
2016
8
Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). ( 26953343 )
2016
9
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. ( 27170748 )
2016
10
Qualitative study on the shifting sociocultural meanings of the facemask in Hong Kong since the severe acute respiratory syndrome (SARS) outbreak: implications for infection control in the post-SARS era. ( 27145823 )
2016
11
The contribution of the cytoplasmic retrieval signal of severe acute respiratory syndrome coronavirus to intracellular accumulation of S proteins and incorporation of S protein into virus-like particles. ( 27145752 )
2016
12
Detection of the Severe Acute Respiratory Syndrome-Related Coronavirus and Alphacoronavirus in the Bat Population of Taiwan. ( 27178103 )
2016
13
Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion. ( 27466418 )
2016
14
Thin-Section Computed Tomography Manifestations During Convalescence and Long-Term Follow-Up of Patients with Severe Acute Respiratory Syndrome (SARS). ( 27501327 )
2016
15
Emerging infectious diseases: Focus on infection control issues for novel coronaviruses (Severe Acute Respiratory Syndrome-CoV and Middle East Respiratory Syndrome-CoV), hemorrhagic fever viruses (Lassa and Ebola), and highly pathogenic avian influenza viruses, A(H5N1) and A(H7N9). ( 27131142 )
2016
16
Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats. ( 27213718 )
2016
17
Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. ( 26015500 )
2015
18
Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step. ( 25552710 )
2015
19
Severe acute respiratory syndrome coronaviruses with mutations in the e protein are attenuated and promising vaccine candidates. ( 25609816 )
2015
20
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins. ( 26041291 )
2015
21
Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques. ( 26647718 )
2015
22
Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor. ( 25907116 )
2015
23
ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus. ( 26433221 )
2015
24
Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference. ( 26378163 )
2015
25
Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism. ( 26320399 )
2015
26
Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2. ( 25348530 )
2015
27
Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. ( 26719272 )
2015
28
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. ( 26392224 )
2015
29
Brief Report: Incubation Period Duration and Severity of Clinical Disease Following Severe Acute Respiratory Syndrome Coronavirus Infection. ( 26133021 )
2015
30
New coronavirus outbreak. Lessons learned from the severe acute respiratory syndrome epidemic. ( 25591619 )
2015
31
Severe acute respiratory syndrome-associated coronavirus vaccines formulated with delta inulin adjuvants provide enhanced protection while ameliorating lung eosinophilic immunopathology. ( 25520500 )
2015
32
Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection. ( 25818534 )
2015
33
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome. ( 26331680 )
2015
34
Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination. ( 26269185 )
2015
35
Controlling Middle East Respiratory Syndrome: Lessons Learned From Severe Acute Respiratory Syndrome. ( 26240205 )
2015
36
Inhibition of NF-I_B-Mediated Inflammation in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice Increases Survival. ( 24198408 )
2014
37
Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers. ( 25033169 )
2014
38
Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease. ( 24531491 )
2014
39
Severe acute respiratory syndrome vs. the Middle East respiratory syndrome. ( 24626235 )
2014
40
Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis. ( 24788150 )
2014
41
Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection. ( 25056892 )
2014
42
The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis. ( 25122212 )
2014
43
Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses. ( 24642138 )
2014
44
Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay. ( 24501399 )
2014
45
Identification of diverse alphacoronaviruses and genomic characterization of a novel severe acute respiratory syndrome-like coronavirus from bats in China. ( 24719429 )
2014
46
Spatial pattern of severe acute respiratory syndrome in-out flow in 2003 in Mainland China. ( 25551367 )
2014
47
TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein. ( 24227843 )
2014
48
Effects of Toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine. ( 24850731 )
2014
49
Severe acute respiratory syndrome: 11 years later--a radiology perspective. ( 25247939 )
2014
50
Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus. ( 24885320 )
2014

Variations for Severe Acute Respiratory Syndrome

Expression for Severe Acute Respiratory Syndrome

Search GEO for disease gene expression data for Severe Acute Respiratory Syndrome.

Pathways for Severe Acute Respiratory Syndrome

Pathways related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CCL2 CCL5 CD209 CD40LG CXCL10 CXCL8
2
Show member pathways
13.65 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
3
Show member pathways
13.53 CCL2 CCL5 CXCL8 IFNA1 IFNB1 IFNG
4
Show member pathways
13.39 CCL2 CCL5 CD40LG CXCL10 CXCL8 STAT1
5
Show member pathways
13.22 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
6
Show member pathways
12.97 CCL2 CCL5 CD209 CXCL8 IFNA1 IFNB1
7
Show member pathways
12.85 CCL2 CCL5 CXCL10 CXCL8 STAT1
8
Show member pathways
12.85 CD40LG CXCL8 IFNA1 IFNG STAT1 TNF
9
Show member pathways
12.7 CCL5 CXCL10 CXCL8 IFNA1 IFNB1 IFNG
10
Show member pathways
12.63 CCL2 CCL5 CXCL10 CXCL8 IFNA1 IFNB1
11
Show member pathways
12.55 IFNA1 IFNB1 IFNG IRF3 STAT1
12
Show member pathways
12.49 IFNA1 IFNB1 IFNG TNF
13
Show member pathways
12.35 CCL2 CXCL10 CXCL8 IFNG TNF
14
Show member pathways
12.32 CCL2 CCL5 IFNG TNF
15
Show member pathways
12.3 IFNA1 IFNB1 IFNG STAT1
16
Show member pathways
12.27 CXCL8 IFNG IRF3 STAT1 TNF
17
Show member pathways
12.26 CXCL8 IFNB1 IRF3 TNF
18
Show member pathways
12.25 CD40LG IFNG STAT1 TNF
19
Show member pathways
12.21 IFNA1 IFNB1 IFNG STAT1
20
Show member pathways
12.2 CXCL10 CXCL8 IFNB1 IFNG STAT1 TNF
21
Show member pathways
12.13 CCL2 CCL5 CD209 CLEC4M CXCL10 CXCL8
22 12.12 CD209 CLEC4M IFNA1 IFNB1 IFNG STAT1
23 12.1 CCL2 CCL5 CD40LG CXCL10 IFNA1 IFNG
24 12.09 CXCL8 IFNA1 IFNB1 IRF3 STAT1 TNF
25 12.06 IFNB1 IFNG STAT1 TNF
26
Show member pathways
12.04 CCL2 CCL5 CXCL10 CXCL8
27 12.04 CCL2 CXCL10 CXCL8 IFNG TNF
28
Show member pathways
12.01 CXCL8 IFNA1 IFNB1 IFNG IRF3 STAT1
29 12 CCL2 CXCL8 STAT1 TNF
30 11.96 CCL2 CCL5 CXCL10 TNF
31
Show member pathways
11.92 IFNG STAT1 TNF
32 11.92 CCL2 CXCL8 STAT1 TNF
33 11.91 CXCL8 IFNB1 IFNG
34 11.9 CCL2 CCL5 CXCL8 IFNG TNF
35 11.86 CXCL8 IFNG TNF
36 11.86 CD40LG CXCL8 TNF
37 11.79 CXCL8 IFNG STAT1
38
Show member pathways
11.79 CD40LG CXCL8 IFNG TNF
39 11.79 CD209 IFNB1 IFNG TNF
40 11.75 CXCL8 IRF3 TNF
41 11.73 IFNA1 IFNB1 IFNG STAT1
42 11.69 CCL2 CCL5 CXCL8 TNF
43
Show member pathways
11.68 CD40LG CXCL8 IFNG TNF
44 11.62 IFNG STAT1 TNF
45 11.53 CCL2 IFNG TNF
46 11.52 CCL2 CCL5 CXCL10 CXCL8 TNF
47 11.49 CCL2 CD40LG CXCL8 IFNG TNF
48 11.43 CXCL10 IFNB1 IFNG STAT1
49 11.38 ACE2 CCL2 CD40LG
50 11.3 IFNB1 IFNG TNF

GO Terms for Severe Acute Respiratory Syndrome

Cellular components related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ACE2 CCL2 CCL5 CD40LG CTRL CXCL10
2 external side of plasma membrane GO:0009897 9.55 CD209 CD40LG CXCL10 IFNG TNF
3 extracellular region GO:0005576 9.44 ACE2 CCL2 CCL5 CD209 CD40LG CLEC4M

Biological processes related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
id Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.95 CD209 CLEC4M IFNA1 IFNB1 IFNG
2 immune response GO:0006955 9.95 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNG
3 chemotaxis GO:0006935 9.94 CCL2 CCL5 CXCL10 CXCL8
4 viral entry into host cell GO:0046718 9.88 ACE2 CD209 CLEC4M
5 cellular response to interleukin-1 GO:0071347 9.87 CCL2 CCL5 CXCL8
6 cellular response to organic cyclic compound GO:0071407 9.87 CCL2 CCL5 TNF
7 interferon-gamma-mediated signaling pathway GO:0060333 9.86 IFNG IRF3 STAT1
8 B cell differentiation GO:0030183 9.86 CD40LG IFNA1 IFNB1
9 regulation of insulin secretion GO:0050796 9.86 CCL5 IFNG TNF
10 cell chemotaxis GO:0060326 9.85 CCL2 CCL5 CXCL10
11 negative regulation of angiogenesis GO:0016525 9.85 CCL2 CXCL10 STAT1
12 positive regulation of T cell proliferation GO:0042102 9.85 CCL5 CD40LG IFNG
13 defense response GO:0006952 9.85 CXCL10 CXCL8 IFNA1 IFNB1 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 CCL5 STAT1 TNF
15 chemokine-mediated signaling pathway GO:0070098 9.84 CCL2 CCL5 CXCL10 CXCL8
16 antigen processing and presentation GO:0019882 9.83 CD209 CLEC4M IFNG
17 negative regulation of viral genome replication GO:0045071 9.81 CCL5 IFNB1 TNF
18 neutrophil chemotaxis GO:0030593 9.81 CCL2 CCL5 CXCL8 IFNG
19 type I interferon signaling pathway GO:0060337 9.8 IFNA1 IFNB1 IRF3 STAT1
20 B cell proliferation GO:0042100 9.79 CD40LG IFNA1 IFNB1
21 response to exogenous dsRNA GO:0043330 9.78 IFNA1 IFNB1 IRF3
22 protein kinase B signaling GO:0043491 9.77 CCL2 CCL5 TNF
23 cellular response to fibroblast growth factor stimulus GO:0044344 9.77 CCL2 CCL5 CXCL8
24 response to virus GO:0009615 9.77 CCL5 CXCL10 IFNB1 IFNG TNF
25 regulation of type I interferon-mediated signaling pathway GO:0060338 9.76 IFNA1 IFNB1 STAT1
26 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.74 IFNA1 IFNB1 IFNG
27 positive regulation of monocyte chemotaxis GO:0090026 9.73 CCL2 CCL5 CXCL10
28 positive regulation of cell adhesion GO:0045785 9.73 CCL2 CCL5 IFNG TNF
29 negative regulation of growth of symbiont in host GO:0044130 9.72 IFNG TNF
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IFNG TNF
31 positive regulation of macrophage chemotaxis GO:0010759 9.72 CCL2 CCL5
32 cellular response to interferon-beta GO:0035458 9.72 IFNB1 STAT1
33 macrophage chemotaxis GO:0048246 9.71 CCL2 CCL5
34 positive regulation of T cell migration GO:2000406 9.71 CCL5 CXCL10
35 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG STAT1
36 PERK-mediated unfolded protein response GO:0036499 9.71 CCL2 CXCL8
37 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.7 CCL5 CXCL8
38 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IFNG TNF
39 neutrophil activation GO:0042119 9.69 CCL5 CXCL8
40 modulation by virus of host morphology or physiology GO:0019048 9.67 CD209 CLEC4M
41 cellular response to dsRNA GO:0071359 9.66 IFNB1 IRF3
42 cell-cell recognition GO:0009988 9.65 CD209 CLEC4M
43 regulation of immunoglobulin secretion GO:0051023 9.65 CD40LG TNF
44 viral genome replication GO:0019079 9.65 CCL2 CD209 CLEC4M
45 receptor biosynthetic process GO:0032800 9.63 ACE2 TNF
46 virion attachment to host cell GO:0019062 9.63 CD209 CLEC4M
47 defense response to virus GO:0051607 9.63 CXCL10 IFNA1 IFNB1 IFNG IRF3 STAT1
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IFNG TNF
49 peptide antigen transport GO:0046968 9.62 CD209 CLEC4M
50 lipopolysaccharide-mediated signaling pathway GO:0031663 9.62 CCL2 CCL5 IRF3 TNF

Molecular functions related to Severe Acute Respiratory Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.43 ACE2 CD209 CLEC4M
2 tumor necrosis factor receptor binding GO:0005164 9.33 CD40LG STAT1 TNF
3 virion binding GO:0046790 9.32 CD209 CLEC4M
4 cytokine activity GO:0005125 9.28 CCL2 CCL5 CD40LG CXCL10 CXCL8 IFNA1
5 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL8

Sources for Severe Acute Respiratory Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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