MCID: SVR022
MIFTS: 17

Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related malady

Immune diseases category

Summaries for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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MalaCards: Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related, also known as severe combined immunodeficiency, is related to severe combined immunodeficiency and adenosine deaminase deficiency. An important gene associated with Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related is RAG2 (recombination activating gene 2). The drug pegademase bovine has been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and nk cells.

Aliases & Classifications for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

severe combined immune deficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-positive, rag1/rag2-related 20
severe combined immunodeficiency 60


Related Diseases for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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17GeneCards, 18GeneDecks
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Diseases related to Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1severe combined immunodeficiency11.5
2adenosine deaminase deficiency11.0
3gamma chain deficiency10.8
4leukemia10.7
5omenn syndrome10.6
6obesity10.6
7zap70-related severe combined immunodeficiency10.5
8achondroplasia and severe combined immunodeficiency10.5
9t cell deficiency10.5
10severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive10.5
11prostatitis10.5
12thyroiditis10.5
13severe combined immunodeficiency, athabascan type10.5
14acute leukemia10.4
15lung cancer10.4
16graft versus host disease10.4
17reticular dysgenesis10.4
18severe combined immunodeficiency with sensitivity to ionizing radiation10.4
19hepatitis10.4
20lymphopenia10.4
21myeloma10.4
22x-linked disease10.4
23severe combined immunodeficiency, b cell-negative10.4
24severe combined immunodeficiency due to lck deficiency10.4
25arthritis10.3
26pneumonia10.3
27prostate cancer10.3
28severe combined immunodeficiency, atypical10.3
29immunodeficiency 810.3
30severe combined immunodeficiency due to dna-pkcs deficiency10.3
31digeorge syndrome10.3
32agammaglobulinemia10.3
33combined t cell and b cell immunodeficiency10.3
34herpes simplex10.3
35hodgkin's lymphoma10.3
36multiple myeloma10.3
37rheumatoid arthritis10.3
38severe combined immunodeficiency with microcephaly, growth retardation, and sensitivity to ionizing radiation10.3
39immunodeficiency 1110.3
40scid, autosomal recessive, t-negative/b-positive type10.3
41multiple intestinal atresia10.2
42autoimmune thyroiditis10.2
43x-linked sideroblastic anemia with ataxia10.2
44cd3zeta deficiency10.2
45cd3delta deficiency10.2
46neuronitis10.2
47autoimmune hemolytic anemia10.2
48burkitt's lymphoma10.2
49hypersplenism10.2
50mhc class ii deficiency10.2

Graphical network of the top 20 diseases related to Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related:



Diseases related to severe combined immune deficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-positive, rag1/rag2-related

Clinical Features for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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Drugs & Therapeutics for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related

Drug clinical trials:

Search ClinicalTrials for Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related

Search NIH Clinical Center for Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related

Search CenterWatch for Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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Genetic tests related to Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related:

id Genetic test Affiliating Genes
1 Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related20 RAG2

Anatomical Context for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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MalaCards organs/tissues related to Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related:

32
T cells, B cells, Nk cells

Animal Models for Severe Combined Immune Deficiency, Autosomal Recessive, T... or affiliated genes

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Publications for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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Genetic Variations for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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Expression for genes affiliated with Severe Combined Immune Deficiency, Autosomal Recessive, T...

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related

Search GEO for disease gene expression data for Severe Combined Immune Deficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, Rag1/rag2-Related.

Pathways for genes affiliated with Severe Combined Immune Deficiency, Autosomal Recessive, T...

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Compounds for genes affiliated with Severe Combined Immune Deficiency, Autosomal Recessive, T...

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GO Terms for genes affiliated with Severe Combined Immune Deficiency, Autosomal Recessive, T...

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Products for genes affiliated with Severe Combined Immune Deficiency, Autosomal Recessive, T...

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Severe Combined Immune Deficiency, Autosomal Recessive, T...

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet