MCID: SVR005
MIFTS: 53

Severe Pre-Eclampsia

Categories: Rare diseases, Reproductive diseases, Cardiovascular diseases

Aliases & Classifications for Severe Pre-Eclampsia

MalaCards integrated aliases for Severe Pre-Eclampsia:

Name: Severe Pre-Eclampsia 12 51 14 69
Severe Pre-Eclampsia, Antepartum Condition or Complication 69
Severe Pre-Eclampsia, Postpartum Condition or Complication 69
Severe Pre-Eclampsia, with Delivery 12
Antepartum Severe Pre-Eclampsia 12
Postpartum Severe Pre-Eclampsia 12
Severe Preeclampsia 12
Severe Toxemia 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13129
ICD9CM 34 642.50
ICD10 32 O14.1

Summaries for Severe Pre-Eclampsia

Disease Ontology : 12 A pre-eclampsia that has symptom at least one of the following

MalaCards based summary : Severe Pre-Eclampsia, also known as severe pre-eclampsia, antepartum condition or complication, is related to hellp syndrome and antiphospholipid syndrome. An important gene associated with Severe Pre-Eclampsia is HLA-G (Major Histocompatibility Complex, Class I, G), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Methyldopa and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include colon, placenta and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Severe Pre-Eclampsia

Diseases in the Eclampsia family:

Pre-Eclampsia Severe Pre-Eclampsia

Diseases related to Severe Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 hellp syndrome 30.6 APOH F5 LGALS13 PGF SERPINC1
2 antiphospholipid syndrome 30.5 APOH F5 SERPINC1
3 eclampsia 30.0 ALB F5 HLA-G LGALS13 PGF SERPINC1
4 gestational diabetes 29.9 ADIPOQ LEP RBP4
5 placental insufficiency 29.8 FGR LEP PGF VEGFA
6 renal cell carcinoma, nonpapillary 29.7 HIF1AN HLA-G MMP9 VEGFA
7 diabetes mellitus 29.3 ADIPOQ ALB LEP VEGFA
8 pre-eclampsia 28.7 ADIPOQ APOH F5 HLA-G LEP LEPR
9 placental abruption 28.4 APOH F5 PGF SERPINC1
10 angiokeratoma circumscriptum 10.5 MMP9 VEGFA
11 squamous cell carcinoma of the hypopharynx 10.4 MMP9 VEGFA
12 sick building syndrome 10.4 LEP MMP9 VEGFA
13 acquired generalized lipodystrophy 10.4 ADIPOQ LEP
14 obesity-hypoventilation syndrome 10.3 ADIPOQ LEP
15 microvascular complications of diabetes 1 10.3 MMP9 VCAM1 VEGFA
16 acroosteolysis 10.3 ALB VEGFA
17 lipoblastoma 10.3 LEP LEPR
18 idiopathic recurrent pericarditis 10.3 ADIPOQ LEP
19 brain edema 10.3 ALB MMP9 VEGFA
20 diabetic foot ulcers 10.3 LEPR MMP9
21 gastrointestinal system cancer 10.3 ALB MMP9 VEGFA
22 multiple symmetrical lipomatosis 10.3 ADIPOQ LEP VCAM1
23 adamantinous craniopharyngioma 10.2 MMP9 VEGFA
24 parotitis 10.2 ALB MMP9
25 coronary artery aneurysm 10.2 ADIPOQ LEP VCAM1
26 prediabetes syndrome 10.2 ADIPOQ ALB LEP
27 chronic kidney failure 10.2 ALB LEP VCAM1
28 mild pre-eclampsia 10.2 LEP PGF VCAM1
29 fournier gangrene 10.2 ALB SERPINC1
30 glucose metabolism disease 10.2 ADIPOQ ALB LEP
31 aging 10.1
32 retinitis 10.1
33 lipid metabolism disorder 10.1 ADIPOQ LEP RBP4
34 eating disorder 10.1 ADIPOQ LEP LEPR
35 sleep apnea 10.1 ADIPOQ LEP LEPR
36 bulimia nervosa 2 10.1 ADIPOQ LEP LEPR
37 overnutrition 10.1 ADIPOQ LEP LEPR
38 burns 10.1 ALB SERPINC1
39 retinal detachment 10.1
40 hydatidiform mole, recurrent, 1 10.1
41 thrombotic thrombocytopenic purpura, congenital 10.1
42 hemolytic anemia 10.1
43 cerebritis 10.1
44 endotheliitis 10.1
45 amaurosis fugax 10.0 F5 MMP9
46 microvascular complications of diabetes 5 10.0 ALB PGF VCAM1 VEGFA
47 arteriosclerosis 10.0 ADIPOQ MMP9 VCAM1
48 hypertension, essential 10.0
49 hydrops, lactic acidosis, and sideroblastic anemia 10.0
50 hepatitis 10.0

Graphical network of the top 20 diseases related to Severe Pre-Eclampsia:



Diseases related to Severe Pre-Eclampsia

Symptoms & Phenotypes for Severe Pre-Eclampsia

MGI Mouse Phenotypes related to Severe Pre-Eclampsia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 APOH F5 MMP9 HIF1AN ADIPOQ HLA-G
2 cardiovascular system MP:0005385 10.29 F5 FGR MMP9 HIF1AN ADIPOQ LEP
3 immune system MP:0005387 10.1 LEPR FGR HLA-G ADIPOQ LEP VEGFA
4 embryo MP:0005380 10.06 APLN LEPR F5 LEP VEGFA PGF
5 liver/biliary system MP:0005370 9.97 LEPR F5 HIF1AN ADIPOQ LEP ALB
6 muscle MP:0005369 9.97 APLN LEPR MMP9 HIF1AN ADIPOQ LEP
7 neoplasm MP:0002006 9.8 LEPR MMP9 ADIPOQ LEP ALB PGF
8 renal/urinary system MP:0005367 9.7 LEPR ADIPOQ LEP ALB VEGFA SERPINC1
9 respiratory system MP:0005388 9.5 LEPR HIF1AN ADIPOQ LEP VEGFA PGF
10 vision/eye MP:0005391 9.23 APLN LEPR LEP PGF RBP4 SERPINC1

Drugs & Therapeutics for Severe Pre-Eclampsia

Drugs for Severe Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 147)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4 555-30-6 38853
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 7487-88-9 24083
3
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
4
Captopril Approved Phase 4 62571-86-2 44093
5
Clonidine Approved Phase 4 4205-90-7 2803
6
Dalteparin Approved Phase 4,Phase 3 9005-49-6
7
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 46507594 772
8
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
9
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
10
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
11
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
12
Thrombin Approved, Investigational Phase 4
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
15 tannic acid Approved, Nutraceutical Phase 4,Phase 3
16 Antihypertensive Agents Phase 4,Phase 2,Phase 3
17 Anesthetics Phase 4,Phase 2,Phase 3
18 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1
19 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
20 Antibodies Phase 4,Phase 2
21 Antibodies, Antiphospholipid Phase 4
22 Anticoagulants Phase 4,Phase 3,Phase 2
23 Immunoglobulins Phase 4,Phase 2
24 Micronutrients Phase 4,Phase 3
25 Trace Elements Phase 4,Phase 3
26 Vitamins Phase 4,Phase 3
27 Analgesics Phase 4,Phase 2,Phase 3
28 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3
29 Anticonvulsants Phase 4,Phase 2,Phase 3
30 calcium channel blockers Phase 4,Phase 2,Phase 3
31 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
32 Pharmaceutical Solutions Phase 4,Phase 3
33 Tocolytic Agents Phase 4,Phase 2,Phase 3
34 diuretics Phase 4
35 Natriuretic Agents Phase 4
36 Sodium Potassium Chloride Symporter Inhibitors Phase 4
37 Adrenergic Agents Phase 4,Phase 2,Phase 3
38 Adrenergic Agonists Phase 4,Phase 3,Phase 2
39 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2
40 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
41 Angiotensin-Converting Enzyme Inhibitors Phase 4
42 Autonomic Agents Phase 4,Phase 2,Phase 3
43 HIV Protease Inhibitors Phase 4
44 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
45
protease inhibitors Phase 4
46 Sympatholytics Phase 4
47 calcium heparin Phase 4,Phase 3
48 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
49 Hematinics Phase 4,Phase 3
50 Heparin, Low-Molecular-Weight Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 89)

# Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
3 A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
4 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
5 Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
6 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
7 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
8 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
9 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Active, not recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
10 Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Not yet recruiting NCT03318211 Phase 4 Magnesium Sulfate
11 LMWH to Prevent Preeclampsia and Fetal Growth Restriction Terminated NCT00260520 Phase 4 Dalteparin
12 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
13 Atenativ Effect on Uterine Blood Flow and Preeclampsia Withdrawn NCT02278575 Phase 4 Atenativ
14 Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia Unknown status NCT01382732 Phase 3 Carbetocin;Oxytocin
15 Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol Completed NCT02086994 Phase 3 misoprostol;carbetocin
16 Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia Completed NCT02307201 Phase 2, Phase 3 Magnesium Sulfate
17 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
18 Magnesium Sulfate in Pregnancy and Postpartum Completed NCT02317146 Phase 2, Phase 3 Magnesium Sulfate
19 Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia Completed NCT01988298 Phase 2, Phase 3 Ibuprofen;Acetaminophen
20 New Magnesium Sulphate Protocol for Pre-eclampsia Completed NCT01846156 Phase 3 MgSO4
21 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
22 Oral Nifedipine Versus IV Labetalol in Severe Pre Eclampsia Recruiting NCT03325348 Phase 2, Phase 3 Nifedipine 10 mg;Labetalol
23 The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine Recruiting NCT02558023 Phase 3 Urapidil;Nicardipine
24 Magnesium Sulphate for Preterm Birth (MASP Study) Recruiting NCT01492608 Phase 3 Magnesium sulphate
25 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia Recruiting NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
26 Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care Not yet recruiting NCT03237819 Phase 3 Sulfate, Magnesium;Placebo - Concentrate
27 Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean Withdrawn NCT01451060 Phase 3 Metaraminol;Ephedrine
28 Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery Withdrawn NCT01796522 Phase 3 progesterone 200 mg / day vaginally;nifedipine (60 mg / day orally)
29 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
30 Rosuvastatin in Order to Induce Preeclampsia Resolution in Severe PET up to 48 Hours Following Delivery Unknown status NCT02314286 Phase 1, Phase 2 Rosuvastatin;Placebo
31 Efficacy Study of Digibind for Treatment of Severe Preeclampsia Completed NCT00158743 Phase 2 Anti-digoxin antibody (FAB fragment)
32 Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery Completed NCT01766089 Phase 2 Remifentanil;Dexmedetomidine
33 Disease Modification in Toxaemia of Pregnancy Completed NCT00175695 Phase 2 Recombinant human activated protein C or drotrecogin alpha
34 Safety and Acceptability of a Vaginal Microbicide Completed NCT00111943 Phase 2 1% tenofovir gel
35 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
36 Study of the Efficacy and Safety of DigiFab® in Antepartum Subjects With Severe Preeclampsia Recruiting NCT03008616 Phase 2
37 Should Colon or Non-colon Originated Lesions be Distinguished? Recruiting NCT02939508 Phase 1, Phase 2
38 Usefulness of Extracorporeal Removal of sFLT-1 in Women With Very Early Severe Preeclampsia Terminated NCT02286284 Phase 2
39 Clinical Trial of a COX-2 Inhibitor for the Treatment of Women With Preeclampsia Withdrawn NCT00442676 Phase 2 Celecoxib;Placebo
40 Study of UC-781 Vaginal Microbicide Completed NCT00132444 Phase 1 topical vaginal application of UC-781 gel
41 Effects of Vitamin C Administration on Extravascular Lung Water in Patients With Severe Features of Preeclampsia Not yet recruiting NCT03451266 Phase 1 Vitamin C;placebo
42 Evaluation of the Safety of Relaxin in Preeclampsia Suspended NCT00333307 Phase 1 recombinant human relaxin
43 Antiphospholipid Antibodies and Early Severe Preeclampsia. Unknown status NCT01538121
44 Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia Unknown status NCT00719654
45 Spinal Anaesthesia and Severe Preeclampsia Unknown status NCT02633995
46 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
47 Random Urine Protein-creatinin Ratio to Predict Magnitude of Proteinuria Unknown status NCT01623791
48 Prolongation of Pregnancy in Preeclampsia by Therapeutic Lipid Apheresis Unknown status NCT01967355
49 Vitamin D Treatment and Hypocalcemic Pregnant Women Unknown status NCT02021864 vitamin D3 50,000 unit;prenatal multivitamin
50 Restless Leg Syndrome and Severe Preeclampsia Completed NCT01538147

Search NIH Clinical Center for Severe Pre-Eclampsia

Genetic Tests for Severe Pre-Eclampsia

Anatomical Context for Severe Pre-Eclampsia

MalaCards organs/tissues related to Severe Pre-Eclampsia:

38
Colon, Placenta, Liver, Lung, Kidney, Bone, Endothelial

Publications for Severe Pre-Eclampsia

Articles related to Severe Pre-Eclampsia:

(show top 50) (show all 325)
# Title Authors Year
1
Maternal cardiac output response to colloid preload and vasopressor therapy during spinal anaesthesia for caesarean section in patients with severe pre-eclampsia: a randomised, controlled trial. ( 29086911 )
2018
2
A case of partial hydatidiform molar pregnancy with a placental diploid-triploid mosaicism associated with a euploid viable foetus complicated with severe pre-eclampsia. ( 29421928 )
2018
3
Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion. ( 28232601 )
2017
4
Severe pre-eclampsia before 26A weeks of gestation: how should we counsel women? ( 28229528 )
2017
5
Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia. ( 28868266 )
2017
6
Isolated sixth Cranial Nerve Palsy in a Case Of Severe Pre-Eclampsia Presenting as Postpartum Diplopia. ( 28969214 )
2017
7
Validation of fullPIERS model for prediction of adverse outcomes among women with severe pre-eclampsia. ( 28475234 )
2017
8
Determinants of magnesium sulphate use in women hospitalized at <29 weeks with severe or non-severe pre-eclampsia. ( 29272274 )
2017
9
Prediction of severe pre-eclampsia by a combination of sFlt-1, CT-pro ET1 and blood pressure: exploratory study. ( 28643875 )
2017
10
Re: Serious maternal complications in relation to severe pre-eclampsia: a retrospective cohort study of the impact of hospital volume; Severe maternal morbidity requires regionalisation of obstetric critical care; Guilt, blame and litigation: can an overenthusiastic 'safety culture' cause harm?: Maternal mortality: the heavy psychological burden on centre obstetricians. ( 28670731 )
2017
11
Introduction of management protocol for early-onset severe pre-eclampsia. ( 28150368 )
2017
12
Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A double-blind, randomized and placebo-controlled clinical study. ( 28726273 )
2017
13
Assessment of quality of care among in-patients with postpartum haemorrhage and severe pre-eclampsia at st. Francis hospital nsambya: a criteria-based audit. ( 28086822 )
2017
14
Re: Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre-eclampsia. J. Ambrozic, G. Brzan Simenc, K. Prokselj, N. Tulz, M. Cvijic and M. Lucovnik. Ultrasound Obstet Gynecol 2017; 49: 104-109. ( 28058788 )
2017
15
Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre-eclampsia. ( 27736042 )
2017
16
Epidural therapy for the treatment of severe pre-eclampsia in non labouring women. ( 29181841 )
2017
17
Planned caesarean section versus planned vaginal birth for severe pre-eclampsia. ( 29058762 )
2017
18
Treatment using tadalafil for severe pre-eclampsia with fetal growth restriction. ( 28503744 )
2017
19
Cardiac arrest during emergency cesarean section for severe pre-eclampsia and peripartum cardiomyopathy. ( 26927264 )
2016
20
Antiretrovirals causing severe pre-eclampsia. ( 27939465 )
2016
21
Oral nifedipine vs. intravenous labetalol for treatment of pregnancy-induced severe pre-eclampsia. ( 27578562 )
2016
22
Prospective assessment of neurodevelopment in children following a pregnancy complicated by severe pre-eclampsia. ( 27388354 )
2016
23
Author's reply re: Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case control study. ( 27531337 )
2016
24
Antenatal corticosteroid therapy for foetal maturation in women with eclampsia and severe pre-eclampsia in a rural hospital in Western Tanzania. ( 27543098 )
2016
25
Antiphospholipid antibodies and the risk of severe and non-severe pre-eclampsia: the NOHA case-control study. ( 26782635 )
2016
26
Relation between Helicobacter pylori infection and severe pre-eclampsia complicated by intrauterine growth restriction in a rural area in Egypt. ( 27624279 )
2016
27
Re: Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case control study: Effect of timing of extracorporeal membrane oxygenation during HELLP syndrome. ( 27531338 )
2016
28
Maternal and neonatal outcomes in women with severe pre-eclampsia undergoing cesarean section: a 10-year retrospective study from a single tertiary care center: anesthetic point of view. ( 26952582 )
2016
29
Soluble vascular cell adhesion molecule-1 and magnesium sulfate with nifedipine treatment in Indonesian women with severe pre-eclampsia. ( 28203390 )
2016
30
Ibuprofen versus acetaminophen as a post-partum analgesic for women with severe pre-eclampsia: randomized clinical study. ( 27384376 )
2016
31
Risk factors for cardiopulmonary dysfunction in early-onset severe pre-eclampsia. ( 27452610 )
2016
32
Ovarian reserve in women with a previous history of severe pre-eclampsia. ( 27604242 )
2016
33
Serious maternal complications in relation to severe pre-eclampsia: a retrospective cohort study of the impact of hospital volume. ( 27770512 )
2016
34
Maternal cardiac haemodynamics in severe pre-eclampsia complicated by acute pulmonary oedema: A review. ( 27866432 )
2016
35
Expression of the complement system's activation factors in plasma of patients with early/late-onset severe pre-eclampsia. ( 27461873 )
2016
36
Expression of markers of endoplasmic reticulum stress-induced apoptosis in the placenta of women with early and late onset severe pre-eclampsia. ( 25675914 )
2015
37
[40-OR]: A causal model of magnesium sulphate use in women hospitalized at <29 weeks with severe or non-severe pre-eclampsia. ( 25787390 )
2015
38
Criteria-based audit of quality of care to women with severe pre-eclampsia and eclampsia in a referral hospital in Accra, Ghana. ( 25923663 )
2015
39
Severe pre-eclampsia complicated by HELLP syndrome alterations in the structure of the umbilical cord (morphometric and immunohistochemical study). ( 26019650 )
2015
40
Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia. ( 26352061 )
2015
41
Third-trimester uterine artery Doppler measurement and maternal postpartum outcome among patients with severe pre-eclampsia. ( 26117553 )
2015
42
First trimester placental retinol-binding protein 4 (RBP4) and pregnancy-associated placental protein A (PAPP-A) in the prediction of early-onset severe pre-eclampsia. ( 25633269 )
2015
43
Complications and maternal mortality from severe pre-eclampsia during the first 48hours in an intensive care unit in Morocco. ( 25638711 )
2015
44
Case of soluble fms-like tyrosine kinase 1 apheresis in severe pre-eclampsia developed at 15 weeks' gestation. ( 26094569 )
2015
45
Transthoracic echocardiographic assessment of haemodynamics in severe pre-eclampsia and HIV in South Africa. ( 25891669 )
2015
46
Circulating chromosome 19 miRNA cluster microRNAs in pregnant women with severe pre-eclampsia. ( 26224638 )
2015
47
Are Meteorological Conditions within the First Trimester of Pregnancy Associated with the Risk of Severe Pre-Eclampsia? ( 26053449 )
2015
48
Characteristics and outcomes of patients with eclampsia and severe pre-eclampsia in a rural hospital in Western Tanzania: a retrospective medical record study. ( 26350344 )
2015
49
Vascular endothelial growth factor (VEGF)-634G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level. ( 26486233 )
2015
50
2-Methoxyestradiol deficiency is strongly related to hypertension in early onset severe pre-eclampsia. ( 26104608 )
2014

Variations for Severe Pre-Eclampsia

Expression for Severe Pre-Eclampsia

Search GEO for disease gene expression data for Severe Pre-Eclampsia.

Pathways for Severe Pre-Eclampsia

GO Terms for Severe Pre-Eclampsia

Cellular components related to Severe Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ADIPOQ ALB APLN APOH F5 LEP
2 extracellular region GO:0005576 9.47 ADIPOQ ALB APLN APOH F5 FGR
3 platelet alpha granule lumen GO:0031093 9.33 ALB F5 VEGFA

Biological processes related to Severe Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.89 ADIPOQ APLN LEP PGF VEGFA
2 angiogenesis GO:0001525 9.81 LEP LEPR PGF VEGFA
3 platelet degranulation GO:0002576 9.67 ALB APOH F5 VEGFA
4 response to ethanol GO:0045471 9.62 ADIPOQ LEP RBP4 VCAM1
5 lactation GO:0007595 9.61 APLN SERPINC1 VEGFA
6 macrophage differentiation GO:0030225 9.58 MMP9 VEGFA
7 leukocyte tethering or rolling GO:0050901 9.58 LEP VCAM1
8 energy reserve metabolic process GO:0006112 9.57 LEP LEPR
9 induction of positive chemotaxis GO:0050930 9.56 PGF VEGFA
10 negative regulation of gluconeogenesis GO:0045721 9.55 ADIPOQ LEPR
11 sexual reproduction GO:0019953 9.54 LEP LEPR
12 leptin-mediated signaling pathway GO:0033210 9.52 LEP LEPR
13 regulation of bone remodeling GO:0046850 9.48 LEP LEPR
14 positive regulation of mast cell chemotaxis GO:0060754 9.46 PGF VEGFA
15 glucose homeostasis GO:0042593 9.46 ADIPOQ LEP LEPR RBP4
16 negative regulation of vasoconstriction GO:0045906 9.4 APLN LEP
17 bone growth GO:0098868 9.26 LEP LEPR
18 response to nutrient GO:0007584 9.26 ADIPOQ LEP SERPINC1 VCAM1
19 response to hypoxia GO:0001666 9.02 ADIPOQ LEP PGF VCAM1 VEGFA

Molecular functions related to Severe Pre-Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.46 APOH PGF SERPINC1 VEGFA
2 hormone activity GO:0005179 9.43 ADIPOQ APLN LEP
3 identical protein binding GO:0042802 9.23 ADIPOQ ALB APOH HLA-G LEPR MMP9
4 vascular endothelial growth factor receptor binding GO:0005172 8.96 PGF VEGFA

Sources for Severe Pre-Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....