MCID: SVR005
MIFTS: 47

Severe Pre-Eclampsia malady

Cardiovascular diseases category

Summaries for Severe Pre-Eclampsia

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34MalaCards
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MalaCards: Severe Pre-Eclampsia, also known as severe pre-eclampsia, with delivery, is related to eclampsia and pre-eclampsia. An important gene associated with Severe Pre-Eclampsia is HLA-G (major histocompatibility complex, class I, G), and among its related pathways are Selected targets of HNF1 and HIF-1-alpha transcription factor network. The compounds gluten and beta-hydroxybutyrate have been mentioned in the context of this disorder. Affiliated tissues include placenta, liver and endothelial, and related mouse phenotypes are immune system and homeostasis/metabolism.

Aliases & Classifications for Severe Pre-Eclampsia

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

severe pre-eclampsia 9 46 63
severe pre-eclampsia, with delivery 9
severe pre-eclampsia, antepartum 63
severe pre-eclampsia, postpartum 63
postpartum severe pre-eclampsia 9
antepartum severe pre-eclampsia 9


External Ids:

Disease Ontology9 DOID:13129
ICD9CM28 642.50
ICD1026 O14.1

Related Diseases for Severe Pre-Eclampsia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Severe Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia32.2HLA-G, SERPINC1
2pre-eclampsia31.7MAOA, VCAM1, SERPINC1, APOH, LEP, HLA-G
3hellp syndrome31.0APOH, SERPINC1
4placental abruption30.4SERPINC1
5purpura30.4SERPINC1
6gestational diabetes30.3IGFBP1, LEP
7migraine30.3MAOA, APOH
8insulin resistance30.2VCAM1, LEP, IGFBP1
9diabetes mellitus30.2VCAM1, SERPINC1, LEP, IGFBP1
10hypertension10.5
11retinitis10.5
12blindness10.5
13cerebritis10.4
14hemolytic anemia10.4
15retinal detachment10.4
16essential hypertension10.3
17hepatitis10.3
18pancreatitis10.3
19triploidy10.3
20endotheliitis10.3
21hypertensive encephalopathy10.2
22thrombotic thrombocytopenic purpura10.2
23pulmonary edema10.2
24placental insufficiency10.2
25thrombocytopenia-absent radius syndrome10.2
26breast cancer10.2
27glomerulonephritis10.2
28periodontal disease10.2
29periodontitis10.2
30renal cell carcinoma10.2
31thrombocytopenia10.2
32thyroiditis10.2
33pheochromocytoma10.2
34aortic coarctation10.2
35hypoxia10.2
36sepsis10.2
37nephrosis10.2
38central retinal vein occlusion10.1APOH
39thrombophlebitis10.1APOH
40retinal artery occlusion10.1APOH
41purpura fulminans10.1SERPINC1
42prothrombin deficiency10.1APOH, SERPINC1
43hepatic vein thrombosis10.1APOH, SERPINC1
44retinal vein occlusion10.1APOH, SERPINC1
45sneddon syndrome10.1APOH, SERPINC1
46antithrombin iii deficiency10.1APOH, SERPINC1
47rabies10.1HLA-G, LEP
48intracranial thrombosis10.1APOH, SERPINC1
49factor xii deficiency10.1APOH, SERPINC1
50protein s deficiency10.1APOH, SERPINC1

Graphical network of the top 20 diseases related to Severe Pre-Eclampsia:



Diseases related to severe pre-eclampsia

Symptoms for Severe Pre-Eclampsia

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Drugs & Therapeutics for Severe Pre-Eclampsia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Severe Pre-Eclampsia

Drug clinical trials:

Search ClinicalTrials for Severe Pre-Eclampsia

Search NIH Clinical Center for Severe Pre-Eclampsia

Search CenterWatch for Severe Pre-Eclampsia

Genetic Tests for Severe Pre-Eclampsia

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Anatomical Context for Severe Pre-Eclampsia

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34MalaCards
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MalaCards organs/tissues related to Severe Pre-Eclampsia:

34
Placenta, Liver, Endothelial, Pancreas, Whole blood, Nk cells, Testes, Breast, Thyroid, Heart, Pituitary

Animal Models for Severe Pre-Eclampsia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Severe Pre-Eclampsia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.0VCAM1, SERPINC1, LEP, HLA-G, IGFBP1
2MP:00053766.9MAOA, HLA-G, LEP, APOH, SERPINC1, VCAM1

Publications for Severe Pre-Eclampsia

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Sources:
53PubMed
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Articles related to Severe Pre-Eclampsia:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
2
First trimester maternal serum placental protein 13 levels in singleton vs. twin pregnancies with and without severe pre-eclampsia. (23729534)
2013
3
Severe pre-eclampsia and hypertensive crises. (23962474)
2013
4
Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. (23888485)
2013
5
Decreased expression of apelin in placentas from severe pre-eclampsia patients. (23844873)
2013
6
Pregnancy outcome in early-onset severe pre-eclampsia in Trinidad. (22036510)
2012
7
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
8
Triploidy without molar change presenting as severe pre-eclampsia and left ventricular failure at 15 weeks. (21973144)
2011
9
Renal hematoma: an unusual cause of acute abdomen and fetal demise in severe pre-eclampsia. (23511047)
2011
10
Transdermal nitroglycerin in patients with severe pre-eclampsia with placental insufficiency: effect on uterine, umbilical and fetal middle cerebral artery resistance indices. (21374750)
2011
11
Comparison between pulse waveform analysis and thermodilution cardiac output determination in patients with severe pre-eclampsia. (21097487)
2011
12
Profile of serum soluble endoglin in pregnant women with severe pre-eclampsia and eclampsia]. (19570416)
2009
13
Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia. (19642860)
2009
14
Bilateral permanent concentric visual field defect secondary to severe pre-eclampsia. (19668739)
2008
15
Impaired maternal cognitive functioning after pregnancies complicated by severe pre-eclampsia: a pilot case-control study. (18382865)
2008
16
Efficacy of nitroglycerine infusion versus sublingual nifedipine in severe pre-eclampsia: a randomized, triple-blind, controlled trial. (18070142)
2008
17
Antithrombin improves fetal condition in women with severe pre-eclampsia before 32 weeks of gestation; a randomized, double-blind, placebo-controlled trial. (18226126)
2008
18
Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes? (18958929)
2008
19
RCAS1 decidual immunoreactivity in severe pre-eclampsia: immune cell presence and activity. (17845206)
2007
20
Early onset severe pre-eclampsia: expectant management at a secondary hospital in close association with a tertiary institution. (15663403)
2005
21
An audit of the use of magnesium sulphate in severe pre-eclampsia and eclampsia. (16147685)
2005
22
Incidence of severe pre-eclampsia, postpartum haemorrhage and sepsis as a surrogate marker for severe maternal morbidity in a European population-based study: the MOMS-B survey. (15663404)
2005
23
A consistent abnormality in the average local smoothness of fetal heart rate in growth-restricted fetuses affected by severe pre-eclampsia. (15894830)
2004
24
Social deprivation and poor access to care as risk factors for severe pre-eclampsia. (14557007)
2003
25
Massive ascites in severe pre-eclampsia: a rare complication. (12452261)
2002
26
Urinary tissue kallikrein excretion in black African women with severe pre-eclampsia. (10203299)
1999
27
Essential fatty acids profile and lipid peroxides in severe pre-eclampsia. (10370762)
1999
28
Nucleated red blood cells in fetuses delivered for early onset severe pre-eclampsia. (10189031)
1999
29
A comparison of severe pre-eclampsia/eclampsia in patients with and without HELLP syndrome. (9610088)
1998
30
The association of early-onset fetal growth restriction, elevated maternal serum alpha-fetoprotein, and the development of severe pre-eclampsia. (9160381)
1997
31
Critical care management of severe pre-eclampsia. (9083225)
1997
32
Oscillometric blood pressure measurements in severe pre-eclampsia: validation of the SpaceLabs 90207. (8616136)
1996
33
Nitric oxide production by human umbilical vessels in severe pre-eclampsia. (7868870)
1994
34
Reversible cerebral, hepatic and renal lesions in severe pre-eclampsia. (1733493)
1992
35
Management of severe pre-eclampsia and eclampsia by UK consultants. (1525094)
1992
36
The effect of severe pre-eclampsia on the pancreas: changes in the serum cationic trypsinogen and pancreatic amylase. (2447935)
1987
37
Preliminary report on the use of magnesium sulfate in cases of severe pre-eclampsia and eclampsia. (3834084)
1985
38
Postpartum migraine and severe pre-eclampsia. (6146833)
1984
39
Left-sided hydrothorax in connection with severe pre-eclampsia. Case reports. (6151919)
1984
40
Severe pre-eclampsia of early onset. (6196074)
1983
41
Haemoconcentration in severe pre-eclampsia. (7126500)
1982
42
Hemodynamic observations in severe pre-eclampsia with a flow-directed pulmonary artery catheter. (7355925)
1980
43
Circulatory and metabolic effects of acute beta 1-blockade in severe pre-eclampsia. (43657)
1979
44
Human leucocyte antigens and mixed lymphocyte reaction in severe pre-eclampsia. (147119)
1978
45
The management of severe pre-eclampsia. (1050623)
1976
46
Microangiopathic hemolytic anemia in severe pre-eclampsia. A review of the literature and pathophysiology. (4857955)
1974
47
The prevention of severe pre-eclampsia. (13770957)
1960
48
Retinal changes in the toxemias of pregnancy. I. History, vomiting of pregnancy, mild and severe pre-eclampsia, and eclampsia. (14885283)
1951
49
The diagnosis and management of mild and severe pre-eclampsia. (15394873)
1949
50
Treatment of a case of severe pre-eclampsia with concentrated serum albumin, salt-poor. (18883079)
1948

Variations for Severe Pre-Eclampsia

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Expression for genes affiliated with Severe Pre-Eclampsia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Severe Pre-Eclampsia

Search GEO for disease gene expression data for Severe Pre-Eclampsia.

Pathways for genes affiliated with Severe Pre-Eclampsia

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Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6APOH, IGFBP1
29.5LEP, IGFBP1
39.5LEP, IGFBP1
49.5VCAM1, HLA-G

Compounds for genes affiliated with Severe Pre-Eclampsia

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1gluten4610.1HLA-G, APOH
2beta-hydroxybutyrate469.8IGFBP1, LEP
3ticlopidine46 1210.8SERPINC1, APOH
4tibolone469.7LEP, SERPINC1
5levonorgestrel46 62 30 1212.7SERPINC1, IGFBP1
6coumarins469.6APOH, MAOA
7p003469.6HLA-G, LEP, APOH
8dehydroepiandrosterone sulfate469.5LEP, IGFBP1
9p002469.5APOH, LEP, IGFBP1
10methotrexate52 46 1211.5APOH, HLA-G, LEP
11budesonide46 52 1211.4LEP, VCAM1
12prednisolone46 30 1211.4APOH, IGFBP1, VCAM1
138-isoprostane469.4APOH, LEP, VCAM1
14alpha tocopherol469.3VCAM1, APOH, LEP
15homocysteine46 2510.3SERPINC1, APOH, VCAM1
16glycerol46 25 1211.3LEP, SERPINC1, IGFBP1
17cocaine46 1210.3VCAM1, APOH, LEP
18pioglitazone30 46 52 1212.3LEP, VCAM1, IGFBP1
19gnrh469.3IGFBP1, SERPINC1, LEP
20folate469.3SERPINC1, VCAM1, APOH
21rosiglitazone30 46 52 25 1213.3VCAM1, IGFBP1, LEP
22paroxetine46 52 30 1212.2LEP, MAOA
23etanercept46 52 1211.2APOH, LEP
24iloprost62 30 46 1212.2SERPINC1, VCAM1
25carbohydrates469.2LEP, VCAM1, IGFBP1
26coumarin46 3 52 2512.1MAOA, SERPINC1
27progesterone46 30 62 25 1213.1LEP, IGFBP1, HLA-G, APOH
28n acetylcysteine469.0LEP, SERPINC1, VCAM1
29lactate469.0APOH, VCAM1, HLA-G, IGFBP1
30nicotine46 30 52 1211.9MAOA, SERPINC1, LEP
31epinephrine46 25 1210.9MAOA, IGFBP1, LEP
32prostacyclin468.8SERPINC1, VCAM1, APOH, LEP
33ascorbic acid46 259.8MAOA, SERPINC1, LEP
34tamoxifen46 52 30 1211.8LEP, SERPINC1, VCAM1, IGFBP1
35phosphatidylinositol468.8IGFBP1, LEP, APOH, VCAM1
36creatinine468.6IGFBP1, HLA-G, LEP, APOH, SERPINC1
37glucose468.6VCAM1, APOH, IGFBP1, LEP
38glutamate468.5MAOA, IGFBP1, APOH, LEP
39cholesterol46 30 25 1211.5APOH, LEP, HLA-G, IGFBP1, VCAM1
40lipid468.5IGFBP1, VCAM1, APOH, LEP, HLA-G
41norepinephrine46 25 1210.5MAOA, IGFBP1, LEP, VCAM1
42fibrinogen468.4VCAM1, APOH, SERPINC1, LEP, IGFBP1
43heparin46 30 25 1211.4SERPINC1, APOH, LEP, IGFBP1, VCAM1
44arginine468.4IGFBP1, APOH, LEP, SERPINC1, VCAM1
45oxygen46 259.2VCAM1, IGFBP1, HLA-G, APOH, MAOA
46cysteine468.1HLA-G, IGFBP1, MAOA, LEP, VCAM1
47vegf468.0VCAM1, IGFBP1, HLA-G, APOH, SERPINC1, LEP
48testosterone46 62 25 1211.0IGFBP1, VCAM1, LEP, SERPINC1, MAOA
49dexamethasone46 52 30 1210.6MAOA, SERPINC1, LEP, HLA-G, IGFBP1, VCAM1
50estrogen467.6LEP, IGFBP1, MAOA, VCAM1, APOH, SERPINC1

GO Terms for genes affiliated with Severe Pre-Eclampsia

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Sources:
17Gene Ontology
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Cellular components related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.9VCAM1, SERPINC1, APOH, LEP, IGFBP1

Biological processes related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:0507769.5VCAM1, HLA-G
2interferon-gamma-mediated signaling pathwayGO:0603339.4VCAM1, HLA-G
3leukocyte tethering or rollingGO:0509019.3VCAM1, LEP
4response to nutrientGO:0075849.0VCAM1, SERPINC1

Molecular functions related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:0081319.0MAOA, VCAM1

Products for genes affiliated with Severe Pre-Eclampsia

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Sources for Severe Pre-Eclampsia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet