MCID: SVR005
MIFTS: 52

Severe Pre-Eclampsia malady

Summaries for Severe Pre-Eclampsia

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MalaCards: Severe Pre-Eclampsia, also known as severe pre-eclampsia, with delivery, is related to pre-eclampsia and eclampsia. An important gene associated with Severe Pre-Eclampsia is HLA-G (major histocompatibility complex, class I, G), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include placenta, liver and endothelial, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Severe Pre-Eclampsia

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

severe pre-eclampsia 8 44 60
severe pre-eclampsia, with delivery 8
severe pre-eclampsia, antepartum 60
severe pre-eclampsia, postpartum 60
antepartum severe pre-eclampsia 8
postpartum severe pre-eclampsia 8


External Ids:

Disease Ontology8 DOID:13129
ICD9CM27 642.50
ICD1025 O14.1

Related Diseases for Severe Pre-Eclampsia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Severe Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1pre-eclampsia32.0HLA-G
2eclampsia32.0SERPINC1, HLA-G
3hellp syndrome30.9APOH, F5, SERPINE1, SERPINC1, GSTP1
4mild pre-eclampsia30.8IGFBP1, VCAM1
5hypertension30.7F5, PGF, LEP, VCAM1, SERPINE1
6hepatitis30.4IGFBP1
7pancreatitis30.4GSTP1
8essential hypertension30.4SERPINE1, LEP, HLA-G
9purpura30.2SERPINC1
10migraine30.2MAOA, APOH
11glomerulonephritis30.2VCAM1
12placental insufficiency30.2IGFBP1, PGF
13placental abruption30.2SERPINC1, F5
14gestational diabetes30.2LEP, PGF, IGFBP1, LSL
15thrombocytopenia30.2SERPINC1, F5, APOH
16diabetes mellitus30.2SERPINC1, SERPINE1, VCAM1, LEP, IGFBP1, LSL
17breast cancer30.2HLA-G, IGFBP1, EBAG9, PGF, LEP, SERPINE1
18retinitis10.4
19cerebritis10.4
20hemolytic anemia10.4
21retinal detachment10.4
22thrombocytopenia-absent radius syndrome10.1
23pulmonary edema10.1
24hypertensive encephalopathy10.1
25thrombotic thrombocytopenic purpura10.1
26periodontal disease10.1
27periodontitis10.1
28renal cell carcinoma10.1
29thyroiditis10.1
30pheochromocytoma10.1
31cerebrovascular disease10.0APOH
32nephrotic syndrome10.0SERPINC1
33allergic rhinitis10.0VCAM1
34morbid obesity10.0LEP
35rhinitis10.0VCAM1
36retinal artery occlusion10.0APOH
37lung cancer10.0GSTP1
38dementia10.0MAOA
39oral cancer10.0GSTP1
40ischemia10.0PGF
41osteoarthritis10.0VCAM1
42deficiency anemia10.0LSL
43thrombophlebitis10.0APOH
44ovarian hyperstimulation syndrome10.0F5
45meningioma10.0PGF
46myeloma10.0VCAM1, HLA-G
47patent foramen ovale10.0F5
48hypogonadism10.0LEP, LSL
49down syndrome10.0PGF
50hyperthyroidism10.0LSL, LEP

Graphical network of the top 20 diseases related to Severe Pre-Eclampsia:



Diseases related to severe pre-eclampsia

Clinical Features for Severe Pre-Eclampsia

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Drugs & Therapeutics for Severe Pre-Eclampsia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Severe Pre-Eclampsia

Drug clinical trials:

Search ClinicalTrials for Severe Pre-Eclampsia

Search NIH Clinical Center for Severe Pre-Eclampsia

Search CenterWatch for Severe Pre-Eclampsia

Genetic Tests for Severe Pre-Eclampsia

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Anatomical Context for Severe Pre-Eclampsia

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32MalaCards
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MalaCards organs/tissues related to Severe Pre-Eclampsia:

32
Placenta, Liver, Endothelial, Pancreas, Whole blood, Nk cells, Testes, Breast, Thyroid, Heart, Pituitary

Animal Models for Severe Pre-Eclampsia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Severe Pre-Eclampsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.3GSTP1
2MP:00053709.6EGLN2, EGLN3, F5, IGFBP1, HIF1AN, LEP
3MP:00053859.6VCAM1, EGLN2, EGLN3, MAOA, HIF1AN, VASH1
4MP:00053979.5EGLN2, EGLN3, EBAG9, LEP, VCAM1, SERPINE1
5MP:00053809.3SERPINC1, EGLN2, EGLN3, F5, PGF, LEP
6MP:00053879.3EGLN2, EGLN3, IGFBP1, EBAG9, PGF, LEP
7MP:00053769.2F5, EGLN3, EGLN2, HLA-G, APOH, MAOA

Publications for Severe Pre-Eclampsia

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50PubMed
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Articles related to Severe Pre-Eclampsia:

(show top 50)    (show all 289)
idTitleAuthorsYear
1
Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case-control study. (24206102)
2014
2
Association between the presence of autoantibodies against adrenoreceptors and severe pre-eclampsia: a pilot study. (23483958)
2013
3
Cytokine production by non-stimulated peripheral blood NK cells and lymphocytes in early-onset severe pre-eclampsia without HELLP. (23415844)
2013
4
Pregnancy outcome in early-onset severe pre-eclampsia in Trinidad. (22036510)
2012
5
Maternal and perinatal outcome during expectant management of severe pre-eclampsia between 24 and 34A weeks of gestation. (23904701)
2012
6
Triploidy without molar change presenting as severe pre-eclampsia and left ventricular failure at 15 weeks. (21973144)
2011
7
Renal hematoma: an unusual cause of acute abdomen and fetal demise in severe pre-eclampsia. (23511047)
2011
8
Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia. (21585639)
2011
9
Midabdominal aortic coarctation presenting with severe pre-eclampsia. (21397437)
2011
10
Risk factors for early onset severe pre-eclampsia and eclampsia among north Indian women. (21627418)
2011
11
Risk factors of adverse pregnancy outcomes during expectant management of early onset severe pre-eclampsia]. (20450750)
2010
12
Association of maternal serum high sensitive C-reactive protein level with body mass index and severity of pre-eclampsia at third trimester. (20722986)
2010
13
Imitators of severe pre-eclampsia. (19464511)
2009
14
Diurnal blood pressure variation in the evaluation of early onset severe pre-eclampsia. (17913329)
2008
15
Clinical significance of hypoxia inducible factor-prolyl hydroxylase 1 and factor inhibiting hypoxia inducible factor-1 expression in placentas of women with severe pre-eclampsia]. (19134330)
2008
16
Bilateral exudative retinal detachment causing blindness in severe pre-eclampsia. (18097911)
2007
17
Serum and urine inhibin A but not free activin A are endocrine biomarkers of severe pre-eclampsia. (16959203)
2006
18
Early onset severe pre-eclampsia: expectant management at a secondary hospital in close association with a tertiary institution. (15663403)
2005
19
Incidence of severe pre-eclampsia, postpartum haemorrhage and sepsis as a surrogate marker for severe maternal morbidity in a European population-based study: the MOMS-B survey. (15663404)
2005
20
Presumed lupus nephritis with autoimmune haemolysis and thrombocytopenia mimicking severe early onset pre-eclampsia and HELLP syndrome. (16091328)
2005
21
Outcomes of severe pre-eclampsia/eclampsia in Yorkshire 1999/2003. (15957986)
2005
22
Anesthetic management of Cesarean delivery in a patient with hypoplastic anemia and severe pre-eclampsia. (15525619)
2004
23
Severe pre-eclampsia remote from term: what to expect of expectant management. (12389673)
2002
24
Delivery of patients with early onset, severe pre-eclampsia. (11502293)
2001
25
The use of platelet density and volume measurements to estimate the severity of pre-eclampsia. (11122327)
2000
26
Anaesthesia for caesarean section in a patient with recent subarachnoid haemorrhage and severe pre-eclampsia. (10540067)
1999
27
Liver and renal and platelet counts after delivery in patients with severe pre-eclampsia. (9930259)
1998
28
A randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-eclampsia. (9532990)
1998
29
Phenytoin prophylaxis in severe pre-eclampsia and eclampsia. (7833324)
1995
30
Maternal and perinatal outcome of temporizing management in 254 consecutive patients with severe pre-eclampsia remote from term. (8903771)
1995
31
Temporising management of severe pre-eclampsia with and without the HELLP syndrome. (7756201)
1995
32
Expectant management of early onset of severe pre-eclampsia in Durban. (8211521)
1993
33
Management of severe pre-eclampsia and eclampsia by UK consultants. (1525094)
1992
34
Fetal and neonatal outcome in patients with severe pre-eclampsia before 34 weeks. (3576400)
1987
35
General anaesthesia in mothers with severe pre-eclampsia/eclampsia. (3689611)
1987
36
Preliminary report on the use of magnesium sulfate in cases of severe pre-eclampsia and eclampsia. (3834084)
1985
37
Postpartum migraine and severe pre-eclampsia. (6146833)
1984
38
Haemoconcentration in severe pre-eclampsia. (7126500)
1982
39
Placental protein 5 (PP5) in severe pre-eclampsia and eclampsia. (6111499)
1981
40
Severe antithrombin III deficiency in a patient with pre-eclampsia. Observations on the effect of human AT III concentrate transfusion. (7444377)
1980
41
Triploidy syndrome with theca lutein cysts and severe pre-eclampsia. (760530)
1979
42
The management of severe pre-eclampsia and eclampsia. (831744)
1977
43
Severe pre-eclampsia: another great imitator. (945695)
1976
44
Association of microangiopathic hemolytic anemia with severe pre-eclampsia. (1115143)
1975
45
Hormone and enzyme assays in pregnancy. 3. The placental cystine-aminopeptidase and the urinary oestrogens in pregnancies complicated with essential hypertension, mild or severe pre-eclampsia. (4406595)
1974
46
Hormone and enzyme assays in pregnancy. IV. The human chorionic somatomammotrophin, placental cystine-aminopeptidase, progesterone and the urinary oestrogens in pregnancies complicated with essential hypertension, mild or severe pre-eclampsia. (4479542)
1974
47
Serum seromucoid levels in women with previous severe pre-eclampsia or eclampsia. (4696559)
1973
48
Serum seromucoid and the materno-paternal mixed leucocyte reaction following previous severe pre-eclampsia. (4266742)
1973
49
Gross early enlargement of a hydatidiform mole with severe pre-eclampsia. (5830036)
1965
50
Hydatidiform mole with severe pre-eclampsia. (20984677)
1946

Genetic Variations for Severe Pre-Eclampsia

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Expression for genes affiliated with Severe Pre-Eclampsia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Severe Pre-Eclampsia

Search GEO for disease gene expression data for Severe Pre-Eclampsia.

Pathways for genes affiliated with Severe Pre-Eclampsia

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53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Severe Pre-Eclampsia

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8APOH
2dexamethasone44 49 28 1113.8MAOA
3p0054410.7PGF
4coumarins4410.6MAOA, APOH
5heparin44 28 11 2413.6PGF, APOH, VCAM1
6gnrh4410.5IGFBP1
7tamoxifen44 49 28 1113.5IGFBP1, VCAM1, LSL
8ancrod4410.5F5, SERPINE1, SERPINC1
98-isoprostane4410.5APOH, LEP, SERPINE1, VCAM1
10p0034410.4APOH, HLA-G, SERPINE1, LSL
11glucose4410.4APOH, LSL, PGF
12nomegestrol acetate4410.4GSTP1, LSL, SERPINC1
13citalopram49 44 11 2413.4LEP, MAOA, LSL, SERPINE1
14beta-hydroxybutyrate4410.4LEP, LSL, IGFBP1
15kininogen4410.4APOH, F5, SERPINC1, SERPINE1
16raloxifene44 28 49 1113.3LSL, SERPINE1, F5, SERPINC1
17tibolone4410.3SERPINE1, SERPINC1, LEP, F5, LSL
18p0024410.3LEP, F5, IGFBP1, APOH, LSL
19metformin44 49 1112.3LSL, F5, IGFBP1, LEP, SERPINE1
20rosiglitazone44 49 28 11 2414.3IGFBP1, LEP, VCAM1, SERPINE1, LSL
21cyclophosphamide44 49 1112.3SERPINE1, VCAM1, F5, APOH, GSTP1
22folate4410.3F5, VCAM1, APOH, GSTP1, SERPINC1
23c-peptide4410.3SERPINE1, IGFBP1, LEP, LSL
24pioglitazone44 49 28 1113.2IGFBP1, LEP, VCAM1, SERPINE1
25homocysteine44 2411.2F5, LSL, APOH, VCAM1, SERPINE1, SERPINC1
26methotrexate44 49 1112.2LEP, APOH, LSL, GSTP1, SERPINE1, HLA-G
27glycerol44 11 2412.2LEP, GSTP1, IGFBP1, LSL, SERPINC1
28epinephrine44 11 2412.2F5, IGFBP1, GSTP1, LSL, MAOA, LEP
29uric acid44 2411.2LEP, F5, APOH, LCN1, LSL, SERPINE1
30pravastatin44 49 28 11 2414.2LEP, SERPINE1, VCAM1, LSL
31aspirin44 49 28 2413.2APOH, F5, SERPINE1, SERPINC1, GSTP1
32progestin4410.1F5, IGFBP1, SERPINE1, SERPINC1
33prostacyclin4410.1SERPINE1, APOH, SERPINC1, F5, PGF, LEP
34creatinine4410.1HLA-G, F5, IGFBP1, LEP, APOH, LCN1
35oxygen44 2411.1MAOA, HIF1AN, IGFBP1, EGLN3, EGLN2, HLA-G
36ascorbic acid44 2411.1EGLN2, EGLN3, F5, MAOA, LEP, SERPINC1
37levonorgestrel44 59 28 1113.1SERPINC1, IGFBP1, F5
38progesterone44 59 28 11 2414.1SERPINE1, LSL, IGFBP1, F5, APOH, HLA-G
39prednisolone44 28 1112.0LSL, APOH, IGFBP1, VCAM1
40fibrinogen4410.0SERPINE1, IGFBP1, F5, APOH, LSL, LEP
41lactate4410.0VCAM1, IGFBP1, F5, HLA-G, APOH, LSL
42arginine4410.0APOH, GSTP1, SERPINC1, VCAM1, LEP, IGFBP1
43testosterone44 59 11 2412.9IGFBP1, VCAM1, SERPINE1, SERPINC1, GSTP1, MAOA
44cholesterol44 28 11 2412.9LSL, SERPINE1, VCAM1, LEP, F5, HLA-G
45cysteine449.9LCN1, HLA-G, IGFBP1, GSTP1, F5, VCAM1
46lipid449.8PGF, SERPINE1, VCAM1, LEP, IGFBP1, HLA-G
47nitric oxide44 11 2411.7LSL, PGF, APOH, VCAM1, F5, SERPINE1
48atorvastatin44 49 28 11 2413.7F5, PGF, VCAM1, SERPINE1
49alanine449.7LSL, SERPINC1, GSTP1, LCN1, IGFBP1, VCAM1
50vegf449.3SERPINE1, SERPINC1, GSTP1, LEP, PGF, VASH1

GO Terms for genes affiliated with Severe Pre-Eclampsia

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16Gene Ontology
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Cellular components related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.3HTRA4, F5, IGFBP1, PGF, SIGLEC6, LEP
2extracellular spaceGO:0056159.1SERPINC1, APOH, F5, IGFBP1, VASH1, PGF

Biological processes related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-proline hydroxylation to 4-hydroxy-L-prolineGO:01840110.4EGLN3, EGLN2
2negative regulation of fibrinolysisGO:05191810.3SERPINE1, APOH
3leukocyte tethering or rollingGO:05090110.3LEP, VCAM1
4regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.3EGLN2, EGLN3, HIF1AN
5negative regulation of endothelial cell migrationGO:01059610.2VASH1, APOH
6regulation of cell growthGO:00155810.2EBAG9, EGLN2, HTRA4
7cellular response to hypoxiaGO:07145610.2EGLN2, EGLN3, HIF1AN
8positive regulation of blood coagulationGO:03019410.2APOH, SERPINE1
9response to hypoxiaGO:00166610.1VCAM1, LEP, PGF, EGLN3, EGLN2
10negative regulation of blood coagulationGO:03019510.0SERPINE1, APOH

Molecular functions related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.3VCAM1, MAOA
2oxygen sensor activityGO:01982610.1HIF1AN, EGLN2
3peptidyl-proline 4-dioxygenase activityGO:0315459.9EGLN3, EGLN2

Products for genes affiliated with Severe Pre-Eclampsia

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  • Antibodies
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Sources for Severe Pre-Eclampsia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet