Severe Pre-eclampsia malady

MalaCards: Severe Pre-eclampsia, also known as severe pre-eclampsia, with delivery, is related to pre-eclampsia and periodontal disease. An important gene associated with Severe Pre-eclampsia is LSL (Leptin, serum levels of), and among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Cell adhesion molecules (CAMs). The compounds glucose and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include placenta and endothelial, and related mouse phenotypes are respiratory system and renal/urinary system.

Aliases & Descriptions:

severe pre-eclampsia 6 8 32 43 severe pre-eclampsia, with delivery 6 severe pre-eclampsia, antepartum 43

severe pre-eclampsia, postpartum 43 antepartum severe pre-eclampsia 6 postpartum severe pre-eclampsia 6

Diseases related to severe pre-eclampsia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 689)

id	Related Disease	Score	Top Affiliating Genes
1	pre-eclampsia	31.2	SELP, SERPINC1, SERPINE1, VEGFA, VCAM1, LEP
2	periodontal disease	28.2	FN1, IL1B, TNF, CRP, SLC17A5
3	eclampsia	23.6	SELP, SERPINC1, SERPINE1, VEGFA, VCAM1, VASH1
4	periodontitis	22.6	SELP, SERPINE1, VEGFA, VCAM1, FN1, FGR
5	blindness	22.4	SELP, SERPINC1, SERPINE1, VEGFA, LEP, IL1B
6	hypoxia	21.3	SELP, SERPINE1, VEGFA, VCAM1, LEP, LEPR
7	mondor disease	13.8	APOH, F5
8	placental infarction	13.7	SERPINC1, APOH, F5
9	prothrombin deficiency	13.7	SERPINC1, APOH, F5
10	spinal cord infarction	13.7	SERPINC1, APOH, F5
11	amaurosis fugax	13.7	SERPINE1, APOH, F5
12	intracranial thrombosis	13.7	SERPINC1, APOH, F5
13	antithrombin iii deficiency	13.7	SERPINC1, APOH, F5
14	purpura fulminans	13.7	SERPINC1, APOH, F5
15	sneddon syndrome	13.7	SERPINC1, APOH, F5
16	placental abruption	13.7	SERPINC1, F5
17	catastrophic antiphospholipid syndrome	13.7	SERPINE1, APOH, F5
18	legg-calve-perthes disease	13.7	SERPINC1, F5
19	postphlebitic syndrome	13.7	SERPINC1, F5
20	hepatic vein thrombosis	13.7	SERPINC1, SERPINE1
21	patent foramen ovale	13.7	SERPINC1, APOH, F5
22	central retinal artery occlusion	13.6	SERPINC1, SERPINE1, F5
23	coronary thrombosis	13.6	SERPINC1, SERPINE1, F5
24	bleeding diathesis due to gnaq deficiency	13.6	SERPINC1, SERPINE1, F5
25	laron syndrome	13.6	IGFBP1, LSL, ADIPOQ
26	congenital generalized lipodystrophy	13.6	LEP, LSL, ADIPOQ
27	sycp3-related pregnancy loss, susceptibility to	13.6	SERPINC1, APOH, F5, HLA-G
28	leptin receptor deficiency	13.6	LEP, LEPR
29	protein c deficiency	13.6	SERPINC1, SERPINE1, APOH, F5
30	hypothyroidism	13.5	LEP, LSL, ADIPOQ
31	leptin deficiency	13.5	LEP, LEPR, LSL
32	placental insufficiency	13.5	LEP, FGR, IGFBP1, PGF
33	plasminogen activator inhibitor type 1 deficiency	13.5	SERPINE1, KNG1
34	sagittal sinus thrombosis	13.5	SERPINC1, F5
35	transsexualism	13.5	LEP, F5, LSL, ADIPOQ
36	acquired angioedema	13.5	SERPINC1, F5
37	celiac disease	13.5	HLA-DQA1, HLA-DQB1
38	cushing's syndrome	13.5	LEP, IGFBP1, LSL, ADIPOQ
39	factor xii deficiency	13.4	SERPINC1, APOH, F5, KNG1
40	thrombotic thrombocytopenic purpura, acquired	13.4	SELP, SERPINE1, APOH
41	factor viii deficiency	13.4	SELP, SERPINC1, F5
42	neonatal stroke	13.4	SERPINE1, F5, ALB
43	peripheral vertigo	13.4	SERPINC1, APOH, CRP
44	dysfibrinogenemia	13.4	SERPINC1, F5, ALB
45	diabetic angiopathy	13.4	SERPINE1, LEP, FN1
46	venous tributary occlusion of retina	13.4	SERPINC1, SERPINE1, F5, KNG1
47	suppurative otitis media	13.4	SERPINC1, CRP
48	hypofibrinogenemia	13.4	SERPINC1, SERPINE1, ALB
49	hypogonadotropism	13.4	LEP, LEPR, F5, LSL
50	sleep apnea	13.4	LEP, LSL, KNG1, ADIPOQ

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to severe pre-eclampsia:

²²

MGI Mouse Phenotypes related to severe pre-eclampsia:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.8	PGF, HIF1AN, LEPR, SELP
2	renal/urinary system phenotype	MP:0005367	9.7	SELP, LEPR
3	integument phenotype	MP:0010771	9.6	EGLN3, EGLN2, F5, GSTP1, LEPR, SELP
4	hematopoietic system phenotype	MP:0005397	9.5	EBAG9, EGLN3, EGLN2, HLA-DQB1, HLA-DQA1
5	liver/biliary system phenotype	MP:0005370	9.5	SOD1, IGFBP1, VEGFA, SERPINC1
6	growth/size phenotype	MP:0005378	9.2	ADIPOQ, HIF1AN, GSTP1, LEP, VCAM1, SERPINE1
7	adipose tissue phenotype	MP:0005375	9.0	PGF, HIF1AN, TNF, LEPR, LEP, SERPINE1
8	tumorigenesis	MP:0002006	8.5	ADIPOQ, PGF, TNF, IL1B, GSTP1, FN1
9	reproductive system phenotype	MP:0005389	8.5	ADIPOQ, EGLN3, EGLN2, TNF, FN1, LEPR
10	immune system phenotype	MP:0005387	8.2	TNF, PGF, EBAG9, ADIPOQ, HLA-DQB1, HLA-DQA1
11	vision/eye phenotype	MP:0005391	7.8	PGF, SLC17A5, SOD1, EGLN3, TNF, LEPR
12	mortality/aging	MP:0010768	7.6	APOH, F5, HLA-DQB1, EGLN3, SLC17A5, IL1B
13	muscle phenotype	MP:0005369	7.5	ADIPOQ, SOD1, HIF1AN, EGLN3, EGLN2, TNF
14	cellular phenotype	MP:0005384	6.6	EGLN2, EGLN3, HIF1AN, SOD1, SLC17A5, ADIPOQ
15	cardiovascular system phenotype	MP:0005385	5.3	SELP, HLA-DQB1, TNF, CRP, EGLN2, EGLN3
16	homeostasis/metabolism phenotype	MP:0005376	4.4	HLA-DQB1, TNF, CRP, EGLN2, EGLN3, HIF1AN

Articles related to severe pre-eclampsia:

(show all 22)

id	Title	Authors	Year	Affiliating Genes
1	Association of leptin level and leptin receptor gene polymorphisms with susceptibility to severe pre-eclampsia]. (21983736)	Guan L.X.... Jiang H.	2011	LEPR, LSL
2	Human leukocyte antigen-G 14 bp deletion polymorphis m in severe pre-eclampsia]. (20646443)	Zhang Z.... Rong S.H.	2010	HLA-G
3	Risk factors of adverse pregnancy outcomes during ex pectant management of early onset severe pre-eclampsia (20450750)	Wu S.W.... Zhang W.Y.	2010	GPT, SLC17A5, LCN1
4	Vasohibin and VEGF protein levels in placentae from pregnancies complicated by severe pre-eclampsia]. (21302448)	Wang F.... Liu R.	2010	VEGFA, VASH1
5	Association of maternal serum high sensitive C-reacti ve protein level with body mass index and severity of pre-eclampsia at third tr imester. (20722986)	Ertas I.E.... Danisman N.	2010	CRP
6	Profile of serum soluble endoglin in pregnant women with severe pre-eclampsia and eclampsia (19570416)	Zhu Y.C.... Liao Q.P.	2009	FGR
7	Antithrombin improves fetal condition in women with severe pre-eclampsia before 32 weeks of gestation; a randomized, double-blind, placebo-controlled trial. (18226126)	Sameshima H.... Kajiwara Y.	2008	SERPINC1
8	Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes? (18958929)	Bienertova-Vasku J.... Unzeitig V.	2008	LEP, ADIPOQ
9	Clinical significance of hypoxia inducible factor-prolyl hydroxylase 1 and factor inhibiting hypoxia inducible factor-1 expression in placentas of women with severe pre-eclampsia (19134330)	Luan N.N.... Shang T.	2008	EGLN2, EGLN3, HIF1AN
10	Role of serum leptin level as a marker of severity of pre eclampsia. (19024177)	Mumtaz F.... Memon A.	2008	ALB, LSL
11	Studies on the compatibility of HLA-Class II alleles in patient couples with severe pre-eclampsia using PCR-RFLP methods. (18593440)	Ooki I.... Tanaka K.	2008	HLA-DQA1, HLA-DQB1, HLA-DRB1
12	Periodontal disease increases the risk of severe pre-eclampsia among pregnant women. (17590155)	Canakci V.... Erturk A.	2007	TNF, IL1B
13	RCAS1 decidual immunoreactivity in severe pre-eclampsia: immune cell presence and activity. (17845206)	Wicherek L.... Kalinka J.	2007	EBAG9
14	Microarray analysis of differentially expressed fetal genes in placental tissue derived from early and late onset severe pre-eclampsia. (16860862)	Nishizawa H.... Udagawa Y.	2007	LEP
15	Genetic polymorphisms of vascular endothelial growth factor in severe pre-eclampsia. (16517614)	Banyasz I.... Rigo J.	2006	VEGFA
16	Oxidative stress is closely related to clinical severity of pre-eclampsia. (16874398)	Chamy V.M.... Madrid E.M.	2006	SOD1
17	Effect of sera on the adhesion of natural killer cells to the endothelium in severe pre-eclampsia. (16984509)	Wei J.... Takeshita T.	2006	VCAM1
18	Is there an increased maternal-infant prevalence of F actor V Leiden in association with severe pre-eclampsia? (11888101)	Currie L.... Ridgway J.	2002	F5
19	The use of platelet density and volume measurements to estimate the severity of pre-eclampsia. (11122327)	JAoremo P.... Forsgren H.	2000	SELP
20	Studies on the HLA-DRB1 genotypes in Japanese women w ith severe pre-eclampsia positive and negative for anticardiolipin antibody usi ng a polymerase chain reaction-restriction fragment length polymorphism method. (10601082)	Takakuwa K.... Tanaka K.	1999	APOH
21	Fibronectin fragments cause an underestimation of plasma fibronectin levels in severe pre-eclampsia. (8837242)	de Jager C.A.... Kirsch R.E.	1996	FN1
22	Nitric oxide production by human umbilical vessels in severe pre-eclampsia. (7868870)	Akar F.... Kanzik I.	1994	KNG1

Genes related to severe pre-eclampsia according to GeneCards:

(show all 38)

id	Symbol	Description	Score	GeneCards Section Context
1	LSL	Leptin, serum levels of	11.0	Publications
2	PGF	placental growth factor	11.0
3	MAOA	monoamine oxidase A	11.0
4	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
5	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
6	IGFBP1	insulin-like growth factor binding protein 1	11.0
7	GSTP1	glutathione S-transferase pi 1	11.0
8	LEP	leptin	11.0	Publications
9	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
10	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0
11	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
12	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
13	VASH1	vasohibin 1	11.0	Publications
14	EGLN2	egl nine homolog 2 (C. elegans)	11.0	Publications
15	HTRA4	HtrA serine peptidase 4	11.0
16	LCN1	lipocalin 1	11.0	Publications
17	SIGLEC6	sialic acid binding Ig-like lectin 6	11.0
18	HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	11.0	Publications
19	EBAG9	estrogen receptor binding site associated, antigen, 9	11.0	Publications
20	EGLN3	egl nine homolog 3 (C. elegans)	11.0	Publications
21	FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	11.0	Publications
22	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	11.0	Publications
23	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
24	FN1	fibronectin 1	11.0	Publications
25	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
26	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
27	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
28	LEPR	leptin receptor	11.0	Publications
29	KNG1	kininogen 1	11.0	Publications
30	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
31	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
32	TNF	tumor necrosis factor	11.0	Publications
33	VEGFA	vascular endothelial growth factor A	11.0	Publications
34	CRP	C-reactive protein, pentraxin-related	11.0	Publications
35	ALB	albumin	11.0	Publications
36	SOD1	superoxide dismutase 1, soluble	11.0	Publications
37	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
38	IL1B	interleukin 1, beta	11.0	Publications

Pathways related to severe pre-eclampsia according to GeneDecks:

(show top 50)    (show all 51)

id	Pathway	Score	Top Affiliating Genes
1	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.6	LEPR
2	Cell adhesion molecules (CAMs)20	10.4	SELP, HLA-DPA1, HLA-G
3	Immune response_ICOS pathway in T-helper cell41	10.3	HLA-DPA1
4	Cellular responses to stress38	10.3	EGLN2, EGLN3, HIF1AN
5	Immune response Antigen presentation by MHC class II10	10.3	HLA-DPA1, HLA-DQA1
6	Renal cell carcinoma20	10.3	PGF, EGLN3, EGLN2
7	Graft-versus-host disease20	10.3	HLA-DPA1, HLA-DQA1, HLA-G
8	CTLA4 Signaling36	10.2	HLA-DPA1, HLA-DQA1
9	Common Pathway38	10.2	SERPINC1, F5
10	Blood Coagulation Signaling Pathways37	10.2	KNG1, F5, SERPINE1, SERPINC1
11	Pathways in cancer20	10.1	VEGFA, GSTP1
12	Complement and coagulation cascades20	10.0	KNG1, F5, SERPINE1, SERPINC1
13	LDL Oxidation in Atherogenesis36	9.8	TNF, IL1B, VCAM1
14	Adipocytokine signaling pathway20	9.7	ADIPOQ, TNF, LEPR, LEP
15	Selected targets of HNF110	9.7	CRP, ALB, IGFBP1, APOH
16	Development Leptin signaling via JAK/STAT and MAPK cascades10	9.6	CRP, LEPR, LEP, VEGFA
17	Immune response NFAT in immune response10	9.6	HLA-DQB1, HLA-DQA1, HLA-DPA1
18	Malaria20	9.6	TNF, IL1B, VCAM1, SELP
19	Selected targets of C/EBPalpha10	9.5	SERPINC1, ALB, ADIPOQ
20	MHC class II antigen presentation38	9.2	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
21	Immune response_Antigen presentation by MHC class II41	9.2	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
22	Calcium Mediated T-Cell Apoptosis36	9.2	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
23	Intestinal immune network for IgA production20	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
24	G-protein signaling N-RAS regulation pathway10	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
25	G-protein signaling_N-RAS regulation pathway41	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
26	Immune response IL-22 signaling pathway10	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
27	Antigen processing and presentation20	9.1	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
28	IL-4 Pathway36	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
29	CTL Mediated Apoptosis36	9.1	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-G
30	Autoimmune thyroid disease20	9.1	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-G
31	Immune response_IL-22 signaling pathway41	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
32	Viral myocarditis20	9.1	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
33	Immune response T cell receptor signaling pathway10	9.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
34	ICos-ICosL Pathway in T-Helper Cell36	9.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
35	Staphylococcus aureus infection20	9.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, SELP
36	Phagosome20	9.0	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
37	Immune response_T cell receptor signaling pathway41	8.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
38	CDC42 Pathway36	8.9	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-G
39	Immune response ICOS pathway in T-helper cell10	8.9	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
40	Asthma20	8.8	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
41	THC Differentiation Pathway36	8.8	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
42	Toxoplasmosis20	8.8	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
43	Systemic lupus erythematosus20	8.7	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF
44	Allograft rejection20	8.7	TNF, HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
45	CD28 Signaling in T-Helper Cell36	8.5	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
46	Leishmaniasis20	8.3	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, IL1B
47	Influenza A20	8.3	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, IL1B
48	Tuberculosis20	8.3	TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, IL1B
49	Type I diabetes mellitus20	8.2	TNF, HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
50	Rheumatoid arthritis20	7.8	PGF, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1

Compounds related to severe pre-eclampsia according to GeneDecks:

(show top 50)    (show all 244)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.5	PGF
2	c-peptide32	10.3	LEP, ADIPOQ, LSL
3	testosterone32 9 18 9	13.1	F5, IGFBP1, GSTP1, SERPINC1, VCAM1, LSL
4	ascorbic acid32 18	11.0	EGLN3, GSTP1, MAOA, SLC17A5, EGLN2
5	n acetylcysteine32	9.9	GPT, SELP, SERPINC1, VCAM1, SLC17A5
6	hyaluronic acid32 18	10.8	SLC17A5, LCN1, GPT, FN1
7	tibolone32	9.6	SERPINC1, LSL, SERPINE1, LEP, F5, CRP
8	pravastatin32 34 9 18 9	13.6	SERPINE1, ADIPOQ, LSL, CRP, SELP
9	aspartate32	9.3	HLA-DQB1, F5, HLA-DQA1, SLC17A5, LCN1, SELP
10	endotoxin32	9.3	CRP, LEPR, APOH, F5, ADIPOQ, SLC17A5
11	heparin32 9 18 9	12.3	ADIPOQ, KNG1, LSL, ALB, IGFBP1, FN1
12	nash32	9.2	ADIPOQ, SLC17A5, LEP, LSL, TNF, GPT
13	estrogen32	9.2	MAOA, IGFBP1, LSL, ADIPOQ, SERPINC1, FGR
14	pioglitazone32 9 9	11.1	ADIPOQ, VEGFA, VCAM1, LEP, FN1, GPT
15	metformin32 34 9 9	12.1	GPT, LEP, IGFBP1, F5, CRP, LSL
16	oxygen32 18	10.1	PGF, SLC17A5, LSL, IGFBP1, LEPR, LCN1
17	cocaine32 9 9	11.0	ADIPOQ, SELP, VCAM1, LEP, SLC17A5, F5
18	dextran sulfate32	9.0	KNG1, F5, APOH, SERPINC1, FN1, SELP
19	kininogen32	8.9	F5, SERPINC1, KNG1, ALB, SELP, SERPINE1
20	p00232	8.8	F5, ADIPOQ, LEP, APOH, IGFBP1, CRP
21	rosiglitazone32 9 18 9	11.8	SERPINE1, GPT, IGFBP1, TNF, VCAM1, SLC17A5
22	candesartan32 9 9	10.7	KNG1, SELP, SERPINE1, ADIPOQ, VEGFA, ALB
23	fenofibrate32 9 9	10.7	SELP, LEP, VCAM1, SLC17A5, ADIPOQ, TNF
24	aspirin32 34 18	10.7	GSTP1, SERPINC1, SELP, FN1, SERPINE1, ADIPOQ
25	8-isoprostane32	8.7	VCAM1, TNF, CRP, APOH, SOD1, ADIPOQ
26	homocysteine32 18	9.6	SERPINC1, ADIPOQ, LSL, CRP, ALB, F5
27	losartan32 34 9 9	11.6	ADIPOQ, SELP, SERPINE1, VCAM1, LEP, CRP
28	malondialdehyde32	8.6	SLC17A5, SOD1, LSL, CRP, APOH, GPT
29	polysulfone32	8.5	SELP, VCAM1, IL1B, ALB, CRP, KNG1
30	folate32	8.5	CRP, ALB, ADIPOQ, SLC17A5, F5, APOH
31	creatinine32	8.5	SELP, SERPINC1, LEP, ADIPOQ, PGF, LSL
32	troglitazone32 42 9 9	11.5	VCAM1, LEP, FN1, IL1B, GPT, TNF
33	prednisolone32 9 9	10.5	SLC17A5, TNF, IGFBP1, CRP, GPT, APOH
34	infliximab32 9 9	10.5	LSL, CRP, TNF, APOH, IL1B, VEGFA
35	simvastatin32 34 42 9 18 9	13.2	CRP, F5, GPT, SLC17A5, ADIPOQ, VEGFA
36	atorvastatin32 34 9 18 9	12.2	SELP, SERPINE1, ADIPOQ, PGF, SLC17A5, CRP
37	genistein32 9 18 9	10.8	IGFBP1, KNG1, TNF, FGR, IL1B, GSTP1
38	uric acid32 18	8.8	APOH, LCN1, LEP, SERPINE1, GPT, F5
39	vitamin a32 9 18 9	10.7	CRP, IGFBP1, GPT, LCN1, LEP, SOD1
40	dexamethasone32 42 34 9 9	11.5	IGFBP1, MAOA, IL1B, FN1, LEPR, LEP
41	cholesterol32 9 18 9	10.5	CRP, LSL, HLA-G, SLC17A5, ADIPOQ, F5
42	fibrinogen32	7.1	TNF, ALB, F5, IGFBP1, GPT, APOH
43	arginine32	7.1	GPT, APOH, FN1, LEPR, LEP, F5
44	nitric oxide32 9 18 9	9.9	LSL, KNG1, APOH, IL1B, FGR, FN1
45	methotrexate32 34 42 9 9	10.8	ADIPOQ, SERPINE1, SLC17A5, LSL, CRP, TNF
46	lactate32	6.7	ADIPOQ, SLC17A5, SOD1, LSL, CRP, TNF
47	lipid32	6.6	ALB, GPT, APOH, HLA-G, LEPR, LEP
48	prostacyclin32	6.6	KNG1, PGF, SOD1, CRP, TNF, F5
49	vegf32	6.5	SERPINC1, LSL, CRP, TNF, HLA-G, F5
50	alanine32	6.2	HLA-DRB1, CRP, SLC17A5, SOD1, LSL, ADIPOQ

Cellular components related to severe pre-eclampsia according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.0	KNG1, ALB, F5, FN1, VEGFA, SERPINE1
2	MHC class II protein complex	GO:042613	8.9	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
3	clathrin-coated endocytic vesicle membrane	GO:030669	8.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
4	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	8.9	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
5	trans-Golgi network membrane	GO:032588	8.8	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
6	ER to Golgi transport vesicle membrane	GO:012507	8.8	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
7	transport vesicle membrane	GO:030658	8.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
8	endocytic vesicle membrane	GO:030666	8.7	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
9	lysosomal membrane	GO:005765	8.2	SLC17A5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
10	plasma membrane	GO:005886	5.9	HLA-DQB1, HLA-DRB1, HLA-G, TNF, SOD1, KNG1
11	extracellular region	GO:005576	5.9	HTRA4, ALB, CRP, SOD1, PGF, SIGLEC6
12	extracellular space	GO:005615	5.6	SELP, F5, ALB, TNF, CRP, SOD1

Biological processes related to severe pre-eclampsia according to GeneDecks:

(show all 26)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of blood coagulation	GO:030195	10.2	SERPINE1, APOH, KNG1
2	chronic inflammatory response to antigenic stimulus	GO:002439	10.0	IL1B
3	leukocyte tethering or rolling	GO:050901	9.9	TNF, LEP, VCAM1, SELP
4	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	9.9	VEGFA, EGLN2, EGLN3, HIF1AN
5	cellular response to stress	GO:033554	9.9	HIF1AN, EGLN3, EGLN2, VEGFA
6	positive regulation of monocyte chemotactic protein-1 production	GO:071639	9.8	ADIPOQ, IL1B
7	positive regulation of interleukin-8 production	GO:032757	9.8	SERPINE1, IL1B, ADIPOQ
8	cellular response to hypoxia	GO:071456	9.8	HIF1AN, EGLN3, EGLN2, VEGFA
9	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.7	TNF, IL1B
10	positive regulation of cytokine production	GO:001819	9.7	SOD1, TNF, LEP
11	sequestering of triglyceride	GO:030730	9.6	TNF, IL1B
12	angiogenesis	GO:001525	9.6	PGF, FN1, VASH1, VEGFA, SERPINE1
13	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.6	IL1B, TNF
14	response to glucocorticoid stimulus	GO:051384	9.4	ADIPOQ, TNF, IL1B, SERPINE1
15	negative regulation of MAP kinase activity	GO:043407	9.3	GSTP1, IL1B, ADIPOQ
16	positive regulation of protein phosphorylation	GO:001934	9.2	VEGFA, IL1B, TNF, ADIPOQ
17	negative regulation of apoptotic process	GO:043066	9.1	TNF, ALB, GSTP1, LEP, VEGFA, SERPINE1
18	T cell costimulation	GO:031295	9.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
19	T cell receptor signaling pathway	GO:050852	9.0	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
20	interferon-gamma-mediated signaling pathway	GO:060333	8.9	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, VCAM1
21	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	8.7	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
22	cytokine-mediated signaling pathway	GO:019221	8.3	HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, IL1B
23	platelet degranulation	GO:002576	8.2	KNG1, SOD1, ALB, F5, FN1, VEGFA
24	platelet activation	GO:030168	8.2	KNG1, SOD1, ALB, F5, FN1, VEGFA
25	response to hypoxia	GO:001666	8.1	VEGFA, ADIPOQ, PGF, EGLN3, EGLN2, CRP
26	blood coagulation	GO:007596	7.9	KNG1, SOD1, ALB, F5, FGR, FN1

Molecular functions related to severe pre-eclampsia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	oxygen sensor activity	GO:019826	10.0	EGLN2, HIF1AN
2	eukaryotic cell surface binding	GO:043499	9.9	ADIPOQ, APOH, SELP
3	peptidyl-proline 4-dioxygenase activity	GO:031545	9.8	EGLN2, EGLN3
4	heparin binding	GO:008201	9.1	SELP, KNG1, PGF, APOH, FN1, VEGFA
5	MHC class II receptor activity	GO:032395	8.8	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
6	protein homodimerization activity	GO:042803	8.3	PGF, SOD1, HIF1AN, CRP, HLA-G, VEGFA