MCID: SVR005
MIFTS: 52

Severe Pre-Eclampsia malady

Summaries for Severe Pre-Eclampsia

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MalaCards: Severe Pre-Eclampsia, also known as severe pre-eclampsia, with delivery, is related to pre-eclampsia and eclampsia. An important gene associated with Severe Pre-Eclampsia is HLA-G (major histocompatibility complex, class I, G), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include placenta, liver and pancreas, and related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Severe Pre-Eclampsia

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

severe pre-eclampsia 8 44 60
severe pre-eclampsia, with delivery 8
severe pre-eclampsia, antepartum 60
severe pre-eclampsia, postpartum 60
antepartum severe pre-eclampsia 8
postpartum severe pre-eclampsia 8


External Ids:

Disease Ontology8 DOID:13129
ICD9CM27 642.50
ICD1025 O14.1

Related Diseases for Severe Pre-Eclampsia

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17GeneCards, 18GeneDecks
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Diseases related to Severe Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1pre-eclampsia32.0HLA-G
2eclampsia32.0SERPINC1, HLA-G
3hellp syndrome30.9APOH, F5, SERPINE1, SERPINC1, GSTP1
4mild pre-eclampsia30.8IGFBP1, VCAM1
5hypertension30.7F5, PGF, LEP, VCAM1, SERPINE1
6hepatitis30.4IGFBP1
7pancreatitis30.4GSTP1
8essential hypertension30.4SERPINE1, LEP, HLA-G
9purpura30.2SERPINC1
10migraine30.2MAOA, APOH
11glomerulonephritis30.2VCAM1
12placental insufficiency30.2IGFBP1, PGF
13placental abruption30.2SERPINC1, F5
14gestational diabetes30.2LEP, PGF, IGFBP1, LSL
15thrombocytopenia30.2SERPINC1, F5, APOH
16diabetes mellitus30.2SERPINC1, SERPINE1, VCAM1, LEP, IGFBP1, LSL
17breast cancer30.2HLA-G, IGFBP1, EBAG9, PGF, LEP, SERPINE1
18retinitis10.4
19cerebritis10.4
20hemolytic anemia10.4
21retinal detachment10.4
22thrombocytopenia-absent radius syndrome10.1
23pulmonary edema10.1
24hypertensive encephalopathy10.1
25thrombotic thrombocytopenic purpura10.1
26periodontal disease10.1
27periodontitis10.1
28renal cell carcinoma10.1
29thyroiditis10.1
30pheochromocytoma10.1
31cerebrovascular disease10.0APOH
32nephrotic syndrome10.0SERPINC1
33allergic rhinitis10.0VCAM1
34morbid obesity10.0LEP
35rhinitis10.0VCAM1
36retinal artery occlusion10.0APOH
37lung cancer10.0GSTP1
38dementia10.0MAOA
39oral cancer10.0GSTP1
40ischemia10.0PGF
41osteoarthritis10.0VCAM1
42deficiency anemia10.0LSL
43thrombophlebitis10.0APOH
44ovarian hyperstimulation syndrome10.0F5
45meningioma10.0PGF
46myeloma10.0VCAM1, HLA-G
47patent foramen ovale10.0F5
48hypogonadism10.0LEP, LSL
49down syndrome10.0PGF
50hyperthyroidism10.0LSL, LEP

Graphical network of the top 20 diseases related to Severe Pre-Eclampsia:



Diseases related to severe pre-eclampsia

Clinical Features for Severe Pre-Eclampsia

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Drugs & Therapeutics for Severe Pre-Eclampsia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Severe Pre-Eclampsia

Drug clinical trials:

Search ClinicalTrials for Severe Pre-Eclampsia

Search NIH Clinical Center for Severe Pre-Eclampsia

Search CenterWatch for Severe Pre-Eclampsia

Genetic Tests for Severe Pre-Eclampsia

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Anatomical Context for Severe Pre-Eclampsia

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32MalaCards
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MalaCards organs/tissues related to Severe Pre-Eclampsia:

32
Placenta, Liver, Pancreas, Endothelial, Testes, Pituitary, Breast, Thyroid, Heart, Whole blood, Nk cells

Animal Models for Severe Pre-Eclampsia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Severe Pre-Eclampsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.3GSTP1
2MP:00053709.6EGLN2, SERPINC1, LEP, HIF1AN, IGFBP1, F5
3MP:00053859.6VCAM1, EGLN2, EGLN3, MAOA, HIF1AN, VASH1
4MP:00053979.5EBAG9, LEP, SERPINC1, SERPINE1, HLA-G, EGLN2
5MP:00053809.3LEP, PGF, F5, EGLN3, EGLN2, SERPINC1
6MP:00053879.3EGLN2, IGFBP1, HLA-G, EBAG9, PGF, LEP
7MP:00053769.2EGLN3, VCAM1, LEP, PGF, HIF1AN, MAOA

Publications for Severe Pre-Eclampsia

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50PubMed
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Articles related to Severe Pre-Eclampsia:

(show top 50)    (show all 289)
idTitleAuthorsYear
1
MMP-9 (-1562 C:T) polymorphism as a biomarker of susceptibility to severe pre-eclampsia. (23387490)
2013
2
Circulating RNA coding genes regulating apoptosis in maternal blood in severe early onset fetal growth restriction and pre-eclampsia. (23429544)
2013
3
Syncytiotrophoblast-derived microparticle shedding in early-onset and late-onset severe pre-eclampsia. (22986096)
2012
4
Severe pre-eclampsia is associated with abnormal trace elements concentrations in maternal and fetal blood. (22007865)
2012
5
Magnesium sulphate in management of severe pre-eclampsia and eclampsia. (23034372)
2012
6
Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia. (22964307)
2012
7
Overexpression of calreticulin in pre-eclamptic placentas: effect on apoptosis, cell invasion and severity of pre-eclampsia. (22415851)
2012
8
Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction. (21810232)
2011
9
Plasma lipocalin-2 levels in pregnant women with pre-eclampsia, and their relation with severity of disease. (20504246)
2011
10
Maternal and perinatal outcome of severe pre-eclampsia in Enugu, Nigeria after introduction of Magnesium sulfate. (22248941)
2011
11
Vasohibin and VEGF protein levels in placentae from pregnancies complicated by severe pre-eclampsia]. (21302448)
2010
12
Risk factors for severe pre-eclampsia and eclampsia in Mulago Hospital, Kampala, Uganda. (23057275)
2010
13
Predicting adverse outcomes in women with severe pre-eclampsia. (19464505)
2009
14
Expectant management in pregnancies with severe pre-eclampsia. (19464504)
2009
15
Insulin resistance in women with a history of severe pre-eclampsia. (19215548)
2009
16
Antithrombin improves fetal condition in women with severe pre-eclampsia before 32 weeks of gestation; a randomized, double-blind, placebo-controlled trial. (18226126)
2008
17
Studies on the compatibility of HLA-Class II alleles in patient couples with severe pre-eclampsia using PCR-RFLP methods. (18593440)
2008
18
Role of serum leptin level as a marker of severity of pre eclampsia. (19024177)
2008
19
Oxidative stress is closely related to clinical severity of pre-eclampsia. (16874398)
2006
20
Partial molar pregnancy with severe pre-eclampsia at 19 weeks' gestation. (17130046)
2006
21
Lactic dehydrogenase as a biochemical marker of adverse pregnancy outcome in severe pre-eclampsia. (16049382)
2005
22
Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation. (15733972)
2005
23
A criteria-based audit of the management of severe pre-eclampsia in Kampala, Uganda. (16226758)
2005
24
Use of parenteral magnesium sulphate in eclampsia and severe pre-eclampsia cases in a rural set up of Bangladesh. (16967813)
2005
25
Utility of misoprostol for labor induction in severe pre-eclampsia and eclampsia. (15327446)
2004
26
Spontaneous renal subcapsular haematoma and acute renal failure complicated by severe pre-eclampsia. (12584299)
2003
27
Cardiac failure caused by severe pre-eclampsia with placental abruption, and its treatment with anti-hypertensive drugs. (14641706)
2003
28
Massive ascites in severe pre-eclampsia: a rare complication. (12452261)
2002
29
Plasma exchange in a woman with thrombotic thrombocytopenic purpura or severe pre-eclampsia. (12197381)
2002
30
The influence of maternal age on pregnancy outcome in patients with early onset, severe pre-eclampsia. (12521852)
2001
31
The expression and concentrations of Fas/APO-1 (CD95) antigen in patients with severe pre-eclampsia. (11164899)
2001
32
Outcome of infants delivered between 24 and 28 weeks' gestation in women with severe pre-eclampsia. (11730491)
2001
33
An open trial comparing isradipine with hydralazine and methyl dopa in the treatment of patients with severe pre-eclampsia. (15512286)
1999
34
Oscillometric blood pressure measurements in severe pre-eclampsia: validation of the SpaceLabs 90207. (8616136)
1996
35
Phenytoin prophylaxis in severe pre-eclampsia and eclampsia. (8199089)
1994
36
Phenytoin prophylaxis in severe pre-eclampsia and eclampsia. (8369243)
1993
37
Fluid balance in severe pre-eclampsia. (1504688)
1992
38
Treatment of severe pre-eclampsia by acetyl salicylic acid. (2064587)
1991
39
Are prophylactic anticonvulsants required in severe pre-eclampsia? (1670890)
1991
40
Effect of nifedipine on Doppler flow velocity waveforms in severe pre-eclampsia. (2513053)
1989
41
The effect of severe pre-eclampsia on the pancreas: changes in the serum cationic trypsinogen and pancreatic amylase. (2447935)
1987
42
Phenytoin infusion in severe pre-eclampsia. (2884504)
1987
43
Left-sided hydrothorax in connection with severe pre-eclampsia. Case reports. (6151919)
1984
44
Severe pre-eclampsia of early onset. (6196074)
1983
45
Case-control study of severe pre-eclampsia of early onset. (6411232)
1983
46
Genetic control of severe pre-eclampsia. (537013)
1979
47
Microangiopathic hemolytic anemia in severe pre-eclampsia. A review of the literature and pathophysiology. (4857955)
1974
48
A condition resembling severe pre-eclampsia occurring under anaesthesia and associated with scoline apnoea. (13786492)
1961
49
Permanent renal lesions after severe pre-eclampsia and eclampsia. (14436491)
1959
50
Retinal changes in the toxemias of pregnancy. I. History, vomiting of pregnancy, mild and severe pre-eclampsia, and eclampsia. (14885283)
1951

Genetic Variations for Severe Pre-Eclampsia

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Expression for genes affiliated with Severe Pre-Eclampsia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Severe Pre-Eclampsia

Search GEO for disease gene expression data for Severe Pre-Eclampsia.

Pathways for genes affiliated with Severe Pre-Eclampsia

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Sources:
53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Severe Pre-Eclampsia

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8APOH
2dexamethasone44 49 28 1113.8MAOA
3p0054410.7PGF
4coumarins4410.6MAOA, APOH
5heparin44 28 11 2413.6PGF, APOH, VCAM1
6gnrh4410.5IGFBP1
7tamoxifen44 49 28 1113.5IGFBP1, VCAM1, LSL
8ancrod4410.5F5, SERPINE1, SERPINC1
98-isoprostane4410.5APOH, LEP, SERPINE1, VCAM1
10p0034410.4APOH, HLA-G, SERPINE1, LSL
11glucose4410.4APOH, LSL, PGF
12nomegestrol acetate4410.4GSTP1, LSL, SERPINC1
13citalopram49 44 11 2413.4LEP, MAOA, LSL, SERPINE1
14beta-hydroxybutyrate4410.4LEP, LSL, IGFBP1
15kininogen4410.4APOH, F5, SERPINC1, SERPINE1
16raloxifene44 28 49 1113.3LSL, SERPINE1, F5, SERPINC1
17tibolone4410.3SERPINE1, SERPINC1, LEP, F5, LSL
18p0024410.3LEP, F5, IGFBP1, APOH, LSL
19metformin44 49 1112.3LSL, F5, IGFBP1, LEP, SERPINE1
20rosiglitazone44 49 28 11 2414.3IGFBP1, LEP, VCAM1, SERPINE1, LSL
21cyclophosphamide44 49 1112.3SERPINE1, VCAM1, F5, APOH, GSTP1
22folate4410.3F5, VCAM1, APOH, GSTP1, SERPINC1
23c-peptide4410.3SERPINE1, IGFBP1, LEP, LSL
24pioglitazone44 49 28 1113.2IGFBP1, LEP, VCAM1, SERPINE1
25homocysteine44 2411.2F5, LSL, APOH, VCAM1, SERPINE1, SERPINC1
26methotrexate44 49 1112.2LEP, APOH, LSL, GSTP1, SERPINE1, HLA-G
27glycerol44 11 2412.2LEP, GSTP1, IGFBP1, LSL, SERPINC1
28epinephrine44 11 2412.2F5, IGFBP1, GSTP1, LSL, MAOA, LEP
29uric acid44 2411.2LEP, F5, APOH, LCN1, LSL, SERPINE1
30pravastatin44 49 28 11 2414.2LEP, SERPINE1, VCAM1, LSL
31aspirin44 49 28 2413.2APOH, F5, SERPINE1, SERPINC1, GSTP1
32progestin4410.1F5, IGFBP1, SERPINE1, SERPINC1
33prostacyclin4410.1SERPINE1, APOH, SERPINC1, F5, PGF, LEP
34creatinine4410.1HLA-G, F5, IGFBP1, LEP, APOH, LCN1
35oxygen44 2411.1MAOA, HIF1AN, IGFBP1, EGLN3, EGLN2, HLA-G
36ascorbic acid44 2411.1EGLN2, EGLN3, F5, MAOA, LEP, SERPINC1
37levonorgestrel44 59 28 1113.1SERPINC1, IGFBP1, F5
38progesterone44 59 28 11 2414.1SERPINE1, LSL, IGFBP1, F5, APOH, HLA-G
39prednisolone44 28 1112.0LSL, APOH, IGFBP1, VCAM1
40fibrinogen4410.0SERPINE1, IGFBP1, F5, APOH, LSL, LEP
41lactate4410.0VCAM1, IGFBP1, F5, HLA-G, APOH, LSL
42arginine4410.0APOH, GSTP1, SERPINC1, VCAM1, LEP, IGFBP1
43testosterone44 59 11 2412.9IGFBP1, VCAM1, SERPINE1, SERPINC1, GSTP1, MAOA
44cholesterol44 28 11 2412.9LSL, SERPINE1, VCAM1, LEP, F5, HLA-G
45cysteine449.9LCN1, HLA-G, IGFBP1, GSTP1, F5, VCAM1
46lipid449.8PGF, SERPINE1, VCAM1, LEP, IGFBP1, HLA-G
47nitric oxide44 11 2411.7LSL, PGF, APOH, VCAM1, F5, SERPINE1
48atorvastatin44 49 28 11 2413.7F5, PGF, VCAM1, SERPINE1
49alanine449.7LSL, SERPINC1, GSTP1, LCN1, IGFBP1, VCAM1
50vegf449.3SERPINE1, SERPINC1, GSTP1, LEP, PGF, VASH1

GO Terms for genes affiliated with Severe Pre-Eclampsia

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16Gene Ontology
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Cellular components related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.3LCN1, HTRA4, F5, IGFBP1, PGF, SIGLEC6
2extracellular spaceGO:0056159.1APOH, F5, IGFBP1, VASH1, PGF, LEP

Biological processes related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-proline hydroxylation to 4-hydroxy-L-prolineGO:01840110.4EGLN3, EGLN2
2negative regulation of fibrinolysisGO:05191810.3SERPINE1, APOH
3leukocyte tethering or rollingGO:05090110.3LEP, VCAM1
4regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.3EGLN2, EGLN3, HIF1AN
5negative regulation of endothelial cell migrationGO:01059610.2VASH1, APOH
6regulation of cell growthGO:00155810.2EBAG9, EGLN2, HTRA4
7cellular response to hypoxiaGO:07145610.2EGLN2, EGLN3, HIF1AN
8positive regulation of blood coagulationGO:03019410.2APOH, SERPINE1
9response to hypoxiaGO:00166610.1VCAM1, LEP, PGF, EGLN3, EGLN2
10negative regulation of blood coagulationGO:03019510.0SERPINE1, APOH

Molecular functions related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.3VCAM1, MAOA
2oxygen sensor activityGO:01982610.1HIF1AN, EGLN2
3peptidyl-proline 4-dioxygenase activityGO:0315459.9EGLN3, EGLN2

Products for genes affiliated with Severe Pre-Eclampsia

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Sources for Severe Pre-Eclampsia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet