MCID: SVR005
MIFTS: 43

Severe Pre-Eclampsia malady

Summaries for Severe Pre-Eclampsia

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33MalaCards
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MalaCards: Severe Pre-Eclampsia, also known as severe pre-eclampsia, with delivery, is related to eclampsia and hellp syndrome. An important gene associated with Severe Pre-Eclampsia is HLA-G (major histocompatibility complex, class I, G), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Related mouse phenotypes are integument and liver/biliary system.

Aliases & Classifications for Severe Pre-Eclampsia

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

severe pre-eclampsia 8 45 61
severe pre-eclampsia, with delivery 8
severe pre-eclampsia, antepartum 61
severe pre-eclampsia, postpartum 61
antepartum severe pre-eclampsia 8
postpartum severe pre-eclampsia 8


External Ids:

Disease Ontology8 DOID:13129
ICD9CM27 642.50
ICD1025 O14.1

Related Diseases for Severe Pre-Eclampsia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Severe Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia32.0SERPINC1, HLA-G
2hellp syndrome30.9APOH, F5, SERPINE1, SERPINC1, GSTP1
3mild pre-eclampsia30.6IGFBP1, VCAM1
4placental insufficiency30.2IGFBP1, PGF
5placental abruption30.2SERPINC1, F5
6gestational diabetes30.2LEP, PGF, IGFBP1, LSL
7thrombocytopenia30.2SERPINC1, F5, APOH
8sepsis30.2SERPINC1, SERPINE1, F5, LSL
9insulin resistance30.2LSL, IGFBP1, PGF, LEP, VCAM1, SERPINE1
10triploidy10.3
11blindness10.3
12thrombocytopenia-absent radius syndrome10.2
13pulmonary edema10.2
14hypertensive encephalopathy10.2
15thrombotic thrombocytopenic purpura10.2
16micro syndrome10.2
17pheochromocytoma10.2
18aortic coarctation10.2
19autonomic dysfunction10.2
20hypoxia10.2
21nephrosis10.2
22pre-eclampsia10.0HLA-G
23cerebrovascular disease10.0APOH
24nephrotic syndrome10.0SERPINC1
25hepatitis10.0IGFBP1
26pancreatitis10.0GSTP1
27purpura10.0SERPINC1
28allergic rhinitis10.0VCAM1
29morbid obesity10.0LEP
30rhinitis10.0VCAM1
31retinal artery occlusion10.0APOH
32lung cancer10.0GSTP1
33dementia10.0MAOA
34oral cancer10.0GSTP1
35ischemia10.0PGF
36osteoarthritis10.0VCAM1
37deficiency anemia10.0LSL
38thrombophlebitis10.0APOH
39ovarian hyperstimulation syndrome10.0F5
40meningioma10.0PGF
41myeloma10.0VCAM1, HLA-G
42migraine10.0MAOA, APOH
43patent foramen ovale10.0F5
44hypogonadism10.0LEP, LSL
45down syndrome10.0PGF
46hyperthyroidism10.0LSL, LEP
47central retinal vein occlusion10.0APOH, F5
48arthritis10.0LEP, PGF
49pancreatic cancer10.0EBAG9
50proliferative diabetic retinopathy10.0VCAM1, IGFBP1

Graphical network of the top 20 diseases related to Severe Pre-Eclampsia:



Diseases related to severe pre-eclampsia

Clinical Features for Severe Pre-Eclampsia

Drugs & Therapeutics for Severe Pre-Eclampsia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Severe Pre-Eclampsia

Drug clinical trials:

Search ClinicalTrials for Severe Pre-Eclampsia

Search NIH Clinical Center for Severe Pre-Eclampsia

Search CenterWatch for Severe Pre-Eclampsia

Genetic Tests for Severe Pre-Eclampsia

Anatomical Context for Severe Pre-Eclampsia

Animal Models for Severe Pre-Eclampsia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Severe Pre-Eclampsia

Sources:
51PubMed
See all sources

Articles related to Severe Pre-Eclampsia:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
2
First trimester maternal serum placental protein 13 levels in singleton vs. twin pregnancies with and without severe pre-eclampsia. (23729534)
2013
3
Factors associated with severe preeclampsia and eclampsia in Jahun, Nigeria. (23983493)
2013
4
Development and assessment of indicators for quality of care in severe preeclampsia/eclampsia and postpartum hemorrhage. (22530567)
2013
5
Prevention and management of severe pre-eclampsia/eclampsia in Afghanistan. (24119329)
2013
6
Successful pregnancy outcome in a case of pheochromocytoma presenting as severe pre-eclampsia with normal urinary catecholamine level. (23869326)
2013
7
Pre-eclampsia and pregnancy-induced hypertension are associated with severe diabetic retinopathy in type 1 diabetes later in life. (22955518)
2013
8
Ultrasonographic Individual Artery Wall Layer Dimensions Indicate Increased Cardiovascular Risk in Previous Severe Pre-eclampsia. (24375803)
2013
9
Decreased levels of folate receptor-I^ and reduced numbers of fetal macrophages (Hofbauer cells) in placentas from pregnancies with severe pre-eclampsia. (23480364)
2013
10
Association between the presence of autoantibodies against adrenoreceptors and severe pre-eclampsia: a pilot study. (23483958)
2013
11
Pregnancy outcome in early-onset severe pre-eclampsia in Trinidad. (22036510)
2012
12
The efficacy of 10gram intramuscular loading dose of MgSO(4) in severe preeclampsia/ eclampsia at a tertiary referral centre in Northwest Nigeria. (23064169)
2012
13
Triploidy without molar change presenting as severe pre-eclampsia and left ventricular failure at 15 weeks. (21973144)
2011
14
Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia. (21585639)
2011
15
Midabdominal aortic coarctation presenting with severe pre-eclampsia. (21397437)
2011
16
Committee Opinion no. 514: emergent therapy for acute-onset, severe hypertension with preeclampsia or eclampsia. (22105295)
2011
17
Vasohibin and VEGF protein levels in placentae from pregnancies complicated by severe pre-eclampsia]. (21302448)
2010
18
Risk factors of adverse pregnancy outcomes during expectant management of early onset severe pre-eclampsia]. (20450750)
2010
19
Predicting adverse outcomes in women with severe pre-eclampsia. (19464505)
2009
20
Cardiac troponin levels in pregnant women with severe pre-eclampsia. (19757267)
2009
21
Expectant management in pregnancies with severe pre-eclampsia. (19464504)
2009
22
Impaired maternal cognitive functioning after pregnancies complicated by severe pre-eclampsia: a pilot case-control study. (18382865)
2008
23
RCAS1 decidual immunoreactivity in severe pre-eclampsia: immune cell presence and activity. (17845206)
2007
24
Use of a gestational carrier for a patient with recurrent adverse pregnancy outcomes from early onset severe pre-eclampsia. (17084396)
2007
25
Periodontal disease increases the risk of severe pre-eclampsia among pregnant women. (17590155)
2007
26
Perinatal outcomes in severe preeclampsia-eclampsia with and without HELLP syndrome. (15591806)
2005
27
Presumed lupus nephritis with autoimmune haemolysis and thrombocytopenia mimicking severe early onset pre-eclampsia and HELLP syndrome. (16091328)
2005
28
Are we increasing serious maternal morbidity by postponing termination of pregnancy in severe pre-eclampsia/eclampsia? (16091314)
2005
29
Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation. (15733972)
2005
30
The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia. (15117599)
2004
31
Selective termination of a twin pregnancy as a treatment of severe pre-eclampsia. (12504939)
2003
32
Is there an increased maternal-infant prevalence of Factor V Leiden in association with severe pre-eclampsia? (11888101)
2002
33
Sulprostone for pregnancy termination in women with severe (pre-) eclampsia. (12175439)
2002
34
The influence of maternal age on pregnancy outcome in patients with early onset, severe pre-eclampsia. (12521852)
2001
35
Severe preeclampsia/eclampsia: hypertensive encephalopathy of pregnancy? (9645984)
1998
36
Oscillometric blood pressure measurements in severe pre-eclampsia: validation of the SpaceLabs 90207. (8616136)
1996
37
Oscilometric blood pressure measurements in severe pre-eclampsia: validation of SpaceLabs 90207. (8688408)
1996
38
Preliminary report on the use of magnesium sulfate in cases of severe pre-eclampsia and eclampsia. (3834084)
1985
39
Serial plasma oncotic pressure levels and echoencephalography during and after delivery in severe pre-eclampsia. (2860445)
1985
40
The predictive value of total estriol; HPL and Hb on perinatal outcome in severe pre-eclampsia. (6516809)
1984
41
Renal-cell carcinoma and mesangiocapillary glomerulonephritis presenting as severe pre-eclampsia. (279841)
1978
42
Severe intravascular coagulation preceding severe pre-eclampsia. (843475)
1977
43
Advanced abdominal pregnancy with severe pre-eclampsia. (1252382)
1976
44
Hormone and enzyme assays in pregnancy. 3. The placental cystine-aminopeptidase and the urinary oestrogens in pregnancies complicated with essential hypertension, mild or severe pre-eclampsia. (4406595)
1974
45
Hormone and enzyme assays in pregnancy. IV. The human chorionic somatomammotrophin, placental cystine-aminopeptidase, progesterone and the urinary oestrogens in pregnancies complicated with essential hypertension, mild or severe pre-eclampsia. (4479542)
1974
46
Serum seromucoid levels in women with previous severe pre-eclampsia or eclampsia. (4696559)
1973
47
The prevention of severe pre-eclampsia. (13770957)
1960
48
Prefrontal lobotomy and severe pre-eclampsia. (13498096)
1958
49
The prevention of eclampsia and severe pre-eclampsia. (13621296)
1958
50
Retinal changes in the toxemias of pregnancy. I. History, vomiting of pregnancy, mild and severe pre-eclampsia, and eclampsia. (14885283)
1951

Genetic Variations for Severe Pre-Eclampsia

Expression for genes affiliated with Severe Pre-Eclampsia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Severe Pre-Eclampsia

Search GEO for disease gene expression data for Severe Pre-Eclampsia.

Pathways for genes affiliated with Severe Pre-Eclampsia

Sources:
54Reactome, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Severe Pre-Eclampsia

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8APOH
2dexamethasone45 50 29 1113.8MAOA
3p0054510.7PGF
4coumarins4510.6MAOA, APOH
5heparin45 29 11 2413.6PGF, APOH, VCAM1
6gnrh4510.5IGFBP1
7tamoxifen45 50 29 1113.5IGFBP1, VCAM1, LSL
8ancrod4510.5F5, SERPINE1, SERPINC1
98-isoprostane4510.5APOH, LEP, SERPINE1, VCAM1
10p0034510.4APOH, HLA-G, SERPINE1, LSL
11glucose4510.4APOH, LSL, PGF
12nomegestrol acetate4510.4GSTP1, LSL, SERPINC1
13citalopram50 45 11 2413.4LEP, MAOA, LSL, SERPINE1
14beta-hydroxybutyrate4510.4LEP, LSL, IGFBP1
15kininogen4510.4APOH, F5, SERPINC1, SERPINE1
16raloxifene45 29 50 1113.3LSL, SERPINE1, F5, SERPINC1
17tibolone4510.3SERPINE1, SERPINC1, LEP, F5, LSL
18p0024510.3LEP, F5, IGFBP1, APOH, LSL
19metformin45 50 1112.3LSL, F5, IGFBP1, LEP, SERPINE1
20rosiglitazone45 50 29 11 2414.3IGFBP1, LEP, VCAM1, SERPINE1, LSL
21cyclophosphamide45 50 1112.3SERPINE1, VCAM1, F5, APOH, GSTP1
22folate4510.3F5, VCAM1, APOH, GSTP1, SERPINC1
23c-peptide4510.3SERPINE1, IGFBP1, LEP, LSL
24pioglitazone45 50 29 1113.2IGFBP1, LEP, VCAM1, SERPINE1
25homocysteine45 2411.2F5, LSL, APOH, VCAM1, SERPINE1, SERPINC1
26methotrexate45 50 1112.2LEP, APOH, LSL, GSTP1, SERPINE1, HLA-G
27glycerol45 11 2412.2LEP, GSTP1, IGFBP1, LSL, SERPINC1
28epinephrine45 11 2412.2F5, IGFBP1, GSTP1, LSL, MAOA, LEP
29uric acid45 2411.2LEP, F5, APOH, LCN1, LSL, SERPINE1
30pravastatin45 50 29 11 2414.2LEP, SERPINE1, VCAM1, LSL
31aspirin45 50 29 2413.2APOH, F5, SERPINE1, SERPINC1, GSTP1
32progestin4510.1F5, IGFBP1, SERPINE1, SERPINC1
33prostacyclin4510.1SERPINE1, APOH, SERPINC1, F5, PGF, LEP
34creatinine4510.1HLA-G, F5, IGFBP1, LEP, APOH, LCN1
35oxygen45 2411.1MAOA, HIF1AN, IGFBP1, EGLN3, EGLN2, HLA-G
36ascorbic acid45 2411.1EGLN2, EGLN3, F5, MAOA, LEP, SERPINC1
37levonorgestrel45 60 29 1113.1SERPINC1, IGFBP1, F5
38progesterone45 60 29 11 2414.1SERPINE1, LSL, IGFBP1, F5, APOH, HLA-G
39prednisolone45 29 1112.0LSL, APOH, IGFBP1, VCAM1
40fibrinogen4510.0SERPINE1, IGFBP1, F5, APOH, LSL, LEP
41lactate4510.0VCAM1, IGFBP1, F5, HLA-G, APOH, LSL
42arginine4510.0APOH, GSTP1, SERPINC1, VCAM1, LEP, IGFBP1
43testosterone45 60 11 2412.9IGFBP1, VCAM1, SERPINE1, SERPINC1, GSTP1, MAOA
44cholesterol45 29 11 2412.9LSL, SERPINE1, VCAM1, LEP, F5, HLA-G
45cysteine459.9LCN1, HLA-G, IGFBP1, GSTP1, F5, VCAM1
46lipid459.8PGF, SERPINE1, VCAM1, LEP, IGFBP1, HLA-G
47nitric oxide45 11 2411.7LSL, PGF, APOH, VCAM1, F5, SERPINE1
48atorvastatin45 50 29 11 2413.7F5, PGF, VCAM1, SERPINE1
49alanine459.7LSL, SERPINC1, GSTP1, LCN1, IGFBP1, VCAM1
50vegf459.3SERPINE1, SERPINC1, GSTP1, LEP, PGF, VASH1

GO Terms for genes affiliated with Severe Pre-Eclampsia

Sources:
16Gene Ontology
See all sources

Cellular components related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.3LCN1, HTRA4, F5, IGFBP1, PGF, SIGLEC6
2extracellular spaceGO:0056159.1APOH, F5, IGFBP1, VASH1, PGF, LEP

Biological processes related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-proline hydroxylation to 4-hydroxy-L-prolineGO:01840110.4EGLN3, EGLN2
2negative regulation of fibrinolysisGO:05191810.3SERPINE1, APOH
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.3EGLN3, EGLN2, HIF1AN
4positive regulation of blood coagulationGO:03019410.3APOH, SERPINE1
5negative regulation of endothelial cell migrationGO:01059610.2APOH, VASH1
6regulation of cell growthGO:00155810.2HTRA4, EGLN2, EBAG9
7cellular response to hypoxiaGO:07145610.2EGLN3, HIF1AN, EGLN2
8leukocyte tethering or rollingGO:05090110.2VCAM1, LEP
9response to hypoxiaGO:00166610.1EGLN2, VCAM1, LEP, PGF, EGLN3
10negative regulation of blood coagulationGO:03019510.0SERPINE1, APOH

Molecular functions related to Severe Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.3VCAM1, MAOA
2oxygen sensor activityGO:01982610.1HIF1AN, EGLN2
3peptidyl-proline 4-dioxygenase activityGO:0315459.9EGLN3, EGLN2

Products for genes affiliated with Severe Pre-Eclampsia

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Sources for Severe Pre-Eclampsia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet