Sex Reversal malady

MalaCards: Sex Reversal is related to campomelic dysplasia and campomelic dysplasia with autosomal sex reversal. An important gene associated with Sex Reversal is SOX9 (SRY (sex determining region Y)-box 9), and among its related pathways are Cytoskeleton remodeling RalB regulation pathway and Cytoskeleton remodeling_RalB regulation pathway. The compounds dmrt and chlordecone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testis and t cells, and related mouse phenotypes are hematopoietic system and respiratory system.

sex reversal 7

Diseases related to sex reversal by text searches and GeneDecks gene sharing:

(show top 50)    (show all 158)

id	Related Disease	Score	Top Affiliating Genes
1	campomelic dysplasia	34.0	ZFY, SRY, KPNB1, SOX10, SOX9
2	campomelic dysplasia with autosomal sex reversal	33.5	KPNB1, SOX9
3	xy sex reversal	32.4	LMX1B, ZFY, FGF9, FGFR2, MAP3K1, CBX2
4	dosage-sensitive sex reversal	32.3	KAT2A, MAGEB2, MAGEB1, ESR1, ESRRB, TRRAP
5	adrenal hypoplasia	31.5	ESR1, ESRRB, CYP11A1, CTNNB1, NR0B1, NR0B2
6	congenital adrenal insufficiency	30.3	CYP11A1, STAR
7	frasier syndrome	28.7	SRY, WT1, SOX9
8	smith-lemli-opitz syndrome	28.5	CGB7, CYP11A1, STAR
9	disorders of sex development	27.5	FOXL2, AR, MAP3K1, CBX2, AKR1C2, AKR1C4
10	dysgerminoma	27.3	CGA, FGFR2, DMRT1, SRY, WT1, TSPY1
11	gonadal dysgenesis	26.5	ZFY, ATRX, CBX2, DMRT1, DMRT2, DMRT3
12	hyperandrogenism	25.4	CGA, AR, AKR1C3, CYP11A1, CYP19A1, NR0B1
13	twinning	25.1	PAX6, CGA, CGB7, AR, FGFR2, CYP11A1
14	cholesterol	23.0	NDN, CGA, AR, MAP3K1, AKR1C3, ESR1
15	thyroiditis	21.4	NDN, LMX1B, CGA, KAT2A, AR, FGFR2
16	neuronitis	18.2	NDN, LMX1B, PAX6, CGA, ATRX, AR
17	lipoid congenital adrenal hyperplasia	13.7	CYP11A1, NR5A1, STAR
18	swyer syndrome	13.7	SRY, TSPY1, SOX9
19	46,xy disorder of sex development and 46,xy complete gonadal dysgenesis	13.7	SRY, NR0B1, NR5A1, WNT4
20	lipoid adrenal hyperplasia	13.7	CYP11A1, NR0B1, STAR
21	x-linked adrenal hypoplasia congenita	13.7	ESRRB, NR0B1, NR5A1, STAR
22	mayer-rokitansky-kuster-hauser syndrome	13.6	DMRT3, TSPY1, WNT4
23	rokitansky-kuster-hauser syndrome	13.6	DMRT3, TSPY1, WNT4
24	glucocorticoid deficiency	13.5	NR0B1, NR1H2, STAR
25	pituitary hormone deficiency	13.3	NR0B1, NR5A1, TSHB, SOX3
26	moebius syndrome	13.3	FOXL2, SRY, SOX10, SOX9
27	premature ovarian failure	13.3	FOXL2, CYP11A1, STAR
28	anorchia	13.2	CGA, SRY, NR5A1
29	luteoma	13.2	CGA, SRY, TSPY1
30	denys-drash syndrome	13.2	SRY, NR5A1, WT1
31	cerebellar hypoplasia	13.1	PAX6, FGFR2, ESRRB, CYP11A1, NR0B1, NR5A1
32	kallmann syndrome	13.0	CGA, ESRRB, NR0B1, NR5A1
33	male pseudohermaphroditism due to defective lh	12.9	AR, NR0B1, NR5A1, WT1
34	addison's disease	12.8	ESRRB, CYP11A1, NR0B1, NR1H2, NR3C1, NR5A1
35	developmental disabilities	12.7	PAX6, FOXL2, FGFR2, DOCK8, NR0B1, SOX10
36	46, xy disorders of sex development	12.7	AR, SRY, NR0B1, NR5A1, WT1, WNT4
37	adenosarcoma	12.7	AR, ESR1, WT1
38	gonadoblastoma	12.7	ZFY, FOXL2, DMRT3, SRY, WT1, TSPY1
39	neuroectodermal endocrine syndrome	12.7	CYP11A1, CYP19A1, NR1H2, NR3C1
40	hyperlipidemia	12.7	ESR1, CYP11A1, NR1H2, NR3C1, WT1, STAR
41	microphthalmia	12.7	PAX6, SRY, CTNNB1, SOX10, SOX9
42	21-hydroxylase deficiency	12.7	CYP11A1, CYP19A1, SRY, NR0B1, NR3C1, NR5A1
43	micropenis	12.6	CGA, AR, NR5A1
44	primary pigmented nodular adrenocortical disease	12.6	ESR1, CYP19A1, CTNNB1, NR3C1
45	desmoid tumor	12.6	AR, ESR1, CTNNB1, WT1
46	adrenal adenoma	12.6	CYP11A1, CYP19A1, CTNNB1, NR0B1, NR1H2, NR5A1
47	uterine disease	12.6	ESR1, CYP19A1
48	bartter disease	12.5	AR, FGFR2, ESR1, CYP11A1, NR0B1, NR3C1
49	adrenocortical carcinoma	12.5	AKR1C3, CYP11A1, CYP19A1, NR0B1, NR5A1, STAR
50	cholera	12.5	CGA, CALM3, CALM1, CYP11A1, NR3C1, STAR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to sex reversal:

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MGI Mouse Phenotypes related to sex reversal:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.0	FGFR2, CBX2, DOCK8, SOX9, WNT4, GATA4
2	respiratory system phenotype	MP:0005388	8.9	DLX2, SOX11, SOX9, GATA4, DMRT2, NDN
3	limbs/digits/tail phenotype	MP:0005371	8.9	SOX9, SOX10, CTNNB1, DMRT2, LMX1B, EVX2
4	no phenotypic analysis	MP:0003012	8.8	SOX9, SOX3, CTNNB1, ESRRB, ESR1, GATA4
5	endocrine/exocrine gland phenotype	MP:0005379	8.8	FOXL2, FGFR2, CBX2, DMRT1, NR5A1, SOX3
6	craniofacial phenotype	MP:0005382	8.6	DMRT2, SOX11, LMX1B, PAX6, DMRT3, KRIT1
7	hearing/vestibular/ear phenotype	MP:0005377	8.5	CTNNB1, CYP19A1, DLX2, ESRRB, FGFR2, FGF9
8	vision/eye phenotype	MP:0005391	8.3	MAP3K1, LMX1B, PAX6, KAT2A, FOXL2, FGF9
9	skeleton phenotype	MP:0005390	7.8	DMRT2, DMRT3, CYP19A1, CTNNB1, NR1H2, ESR1
10	digestive/alimentary phenotype	MP:0005381	7.6	PAX6, SOX11, SOX9, SOX10, NR3C1, CTNNB1
11	behavior/neurological phenotype	MP:0005386	7.2	CTNNB1, NR5A1, SOX10, SOX3, SOX9, NR3C1
12	embryogenesis phenotype	MP:0005380	6.7	CTNNB1, NR5A1, WT1, KRIT1, SOX10, GATA4
13	integument phenotype	MP:0010771	6.6	GATA4, WNT4, SOX9, SOX11, SOX10, NR3C1
14	muscle phenotype	MP:0005369	6.5	FGFR2, CYP19A1, DLX2, NDN, LMX1B, PAX6
15	normal phenotype	MP:0002873	6.0	NR0B2, CTNNB1, CYP19A1, CYP11A1, FGFR2, FGF9
16	cardiovascular system phenotype	MP:0005385	5.9	NR3C1, NR1H2, KRIT1, NR5A1, WT1, SOX11
17	cellular phenotype	MP:0005384	5.1	DLX2, ESR1, CBX2, MAP3K1, FGFR2, FGF9
18	nervous system phenotype	MP:0003631	4.8	EVX2, FGFR2, AR, KAT2A, ESR1, SOX9
19	mortality/aging	MP:0010768	4.7	AR, FOXL2, KAT2A, ATRX, PAX6, LMX1B
20	growth/size phenotype	MP:0005378	4.5	FGF9, PAX6, DLX2, STAR, CYP11A1, CYP19A1
21	reproductive system phenotype	MP:0005389	4.3	PAX6, NR0B1, NR0B2, NR3C1, NR5A1, RSPO1
22	homeostasis/metabolism phenotype	MP:0005376	4.2	NR3C1, NR5A1, NR0B2, NR1H2, NR0B1, MAP3K1

Articles related to sex reversal:

(show top 50)    (show all 101)

id	Title	Authors	Year	Affiliating Genes
1	Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal. (20528776)	Kaur G.... Jans D.A.	2010	SRY
2	A novel SOX9 mutation, 972delC, causes 46,XY sex-reversed campomelic dysplasia with nephrocalcinosis, urolithiasis, and dysgerminoma. (19231556)	Cost N.G.... Baker L.A.	2009	SOX9
3	Sex reversal of the amphibian, Xenopus tropicalis, fo llowing larval exposure to an aromatase inhibitor. (18804292)	Olmstead A.W.... Degitz S.J.	2009	CYP19A1
4	A case of ovine female XY sex reversal syndrome not r elated to anomalies in the sex-determining region Y (SRY). (19864878)	Ferrer L.M.... Lacasta D.	2009	TSPY1
5	Loss of Fgfr2 leads to partial XY sex reversal. (18155190)	Bagheri-Fam S.... Harley V.R.	2008	FGFR2, FGF9
6	DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X-chromosome, gene 1) selectively inhibits transactivation but not transrepression mediated by the glucocorticoid receptor in a LXXLL-dependent manner. (18417736)	Zhou J.... Cidlowski J.A.	2008	NR3C1, NR0B1, ESRRB
7	Analysis of the SRY gene in two sex-reversed XY sisters identifies two new novel point mutations in the high mobility group box domain. (18304538)	Shahid M.... Husain S.A.	2008	SRY
8	Ovotestes and XY sex reversal in a female with an interstitial 9q33.3-q34.1 deletion encompassing NR5A1 and LMX1B causing features of Genitopatellar syndrome. (17431898)	Schlaubitz S.... Lee B.	2007	LMX1B
9	Complete sex reversal in a WAGR syndrome patient. (17935232)	Le Caignec C.... Rival J.M.	2007	WT1, PAX6
10	Dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX1) (NR0B1) and small heterodimer partner (SHP) (NR0B2) form homodimers individually, as well as DAX1-SHP heterodimers. (16709599)	Iyer A.K.... McCabe E.R.B.	2006	ESR1, NR5A1, NR0B1
11	Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum. (16705068)	l Kandari H.... Rasoul M.A.	2006	CYP11A1
12	Complex mosaicism in sex reversed SRY+ male twins. (16276109)	DesGroseilliers M.... Lemieux N.	2006	SOX11
13	A naturally occurring deletion in the SRY promoter region affecting the Sp1 binding site is associated with sex reversal. (16218050)	Assumpcao J.G.... de Mello M.P.	2005	SRY
14	Defective calmodulin-mediated nuclear transport of the sex- determining region of the Y chromosome (SRY) in XY sex reversal. (15746192)	Sim H.... Harley V.R.	2005	CALM1, CALM3, CALM2
15	Homozygous disruption of P450 side-chain cleavage (CYP11A1) is associated with prematurity, complete 46,XY sex reversal, and severe adrenal failure. (15507506)	Hiort O.... Struve D.	2005	CYP11A1
16	Sex reversal syndrome (64,XY; SRY-positive) in a mare demonstrating masculine behaviour. (16130458)	Switonski M.... Nowicka-PosA8uszna A.	2005	SRY
17	Pisrt1, a gene implicated in XX sex reversal, is expressed in gonads of both sexes during mouse development. (16137905)	Loffler K.A.... Koopman P.	2005	FOXL2
18	Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. (15944188)	Bouma G.J.... Eicher E.M.	2005	SOX11
19	Two novel mutations in SRY gene form Chinese sex reversal XY females. (16018252)	Zhou C.... Lu G.X.	2005	SRY, SOX11
20	A microdeletion in the ligand binding domain of human steroidogenic factor 1 causes XY sex reversal without adrenal insufficiency. (15070943)	Correa R.V.... Mendonca B.B.	2004	NR5A1
21	Sry-directed sex reversal in transgenic mice is robust with respect to enhanced DNA bending: comparison of human and murine HMG boxes. (15170344)	Phillips N.B.... Weiss M.A.	2004	SRY
22	Identification of a new nonsense mutation (Tyr129Stop) of the SRY gene in a newborn infant with XY sex-reversal. (15211655)	Giuffre M.... Corsello G.	2004	SRY
23	Differential expression of thyroid-stimulating hormone beta subunit in gonads during sex reversal of orange-spotted and red-spotted groupers. (15196702)	Wang Y.... Gui J.F.	2004	TSHB
24	Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad. (12554773)	Mizusaki H.... Morohashi K.	2003	CTNNB1, NR5A1
25	Defective importin beta recognition and nuclear import of the sex- determining factor SRY are associated with XY sex-reversing mutations. (12764225)	Harley V.R.... Jans D.A.	2003	KPNB1, SRY
26	WT1 gene mutation responsible for male sex reversal and renal failure: the Frasier syndrome. (12932885)	Saylam K.... Simon P.	2003	WT1
27	Role of the LXXLL-motif and activation function 2 domain in subcellular localization of Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1). (12610109)	Kawajiri K.... Morohashi K.	2003	NR5A1, NR0B1, ESRRB
28	Human sex reversal due to impaired nuclear localization of SRY. A clinical correlation. (11641389)	Li B.... Weiss M.A.	2001	SRY
29	Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation. (11563911)	Murphy E.C.... Clore G.M.	2001	SRY
30	Up-regulation of wnt-4 signaling and dosage-sensitive sex reversal in humans. (11283799)	Jordan B.K.... Vilain E.	2001	WNT4
31	Molecular analysis of SRY gene in Brazilian 46,XX sex reversed patients: absence of SRY sequence in gonadal tissue. (11257728)	Domenice S.... Mendonca B.B.	2001	SRY
32	A novel missense mutation in the HMG box region of the SRY gene in a Japanese patient with an XY sex reversal. (10721678)	Okuhara K.... Fujieda K.	2000	SRY
33	The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination. (11069290)	Pask A.... Marshall Graves J.A.	2000	ATRX
34	FISH mapping of the sex-reversal region on human chro mosome 9p in two XY females and in primates. (10780781)	Shan Z.... Haaf T.	2000	DMRT1
35	Localization of SRY by primed in situ labeling in XX and XY sex reversal. (11074498)	Kadandale J.S.... Tharapel A.T.	2000	SRY
36	Mutation analysis of subjects with 46, XX sex reversal and 46, XY gonadal dysgenesis does not support the involvement of SOX3 in testis determination. (11153920)	Lim H.N.... Hawkins J.R.	2000	SOX3, SRY
37	Autosomal XX sex reversal caused by duplication of SOX9. (10588843)	Huang B.... Bartley J.	1999	SOX9
38	Male-to-female sex reversal in M33 mutant mice. (9641679)	Katoh-Fukui Y.... Higashinakagawa T.	1998	CBX2
39	Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9. (8566951)	Wirth J.... Scherer G.	1996	SOX9
40	A family of rapidly evolving genes from the sex reversal critical region in Xp21. (8535061)	Dabovic B.... Camerino G.	1995	NDN, MAGEB2, MAGEB1
41	An SRY mutation causing human sex reversal resolves a general mechanism of structure-specific DNA recognition: application to the four-way DNA junction. (7718558)	Peters R.... Weiss M.A.	1995	SRY
42	Xp duplications and sex reversal. (8570694)	Zanaria E.... Camerino G.	1995	NR0B1
43	Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. (7990924)	Foster J.W.... Schafer A.J.	1994	SOX9
44	Clinical and anatomical spectrum in XX sex reversed p atients. Relationship to the presence of Y specific DNA-sequences. (8033363)	Boucekkine C.... Vilain E.	1994	SRY
45	Analysis of the SRY gene in 22 sex-reversed XY females identifies four new point mutations in the conserved DNA binding domain. (8353496)	Affara N.A.... Ferguson-Smith M.A.	1993	SRY
46	Characterization and sequencing of the sex determining region Y gene (Sry) in Akodon (Cricetidae) species with sex reversed females. (7916665)	Bianchi N.O.... de la Chapelle A.	1993	SRY
47	Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex-reversion in a 46,XY female. (1619028)	Muller J.... Skakkebaek N.E.	1992	SRY
48	Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal. (1349859)	Lau Y.F.... Wiberg U.H.	1992	ZFY
49	Testicular steroidogenesis in X/X sex-reversed mice. (1869316)	O'Shaughnessy P.J.... Cattanach B.M.	1991	CGA
50	The etiology of XX sex reversal. (1976312)	de la Chapelle A.... Maenpaa J.	1990	ZFY

Genes related to sex reversal according to GeneCards:

(show top 50)    (show all 58)

id	Symbol	Description	Score	GeneCards Section Context
1	SOX9	SRY (sex determining region Y)-box 9	11.1	Publications, Aliases & Descriptions, Summaries
2	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.1	Summaries, Publications
3	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.1	Functions, Publications, Aliases & Descriptions
4	CBX2	chromobox homolog 2	11.1	Publications, Summaries
5	MAGEB1	melanoma antigen family B, 1	11.1	Publications, Summaries
6	MAGEB2	melanoma antigen family B, 2	11.1	Publications, Summaries
7	FGF9	fibroblast growth factor 9 (glia-activating factor)	11.1	Publications, Summaries
8	SRXX3	46XX sex reversal 3	11.1	Aliases & Descriptions
9	SRXX2	46XX sex reversal 2	11.1	Aliases & Descriptions
10	DMRT2	doublesex and mab-3 related transcription factor 2	11.1	Summaries, Publications
11	PRKX	protein kinase, X-linked	11.1	Summaries
12	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	11.1	Publications
13	KPNB1	karyopherin (importin) beta 1	11.0	Publications
14	STAR	steroidogenic acute regulatory protein	11.0	Publications
15	SRY	sex determining region Y	11.0	Publications
16	ZFY	zinc finger protein, Y-linked	11.0	Publications
17	TSPY1	testis specific protein, Y-linked 1	11.0	Publications
18	DMRT3	doublesex and mab-3 related transcription factor 3	11.0	Publications
19	KAT2A	K(lysine) acetyltransferase 2A	11.0	Publications
20	NR0B2	nuclear receptor subfamily 0, group B, member 2	11.0	Publications
21	RSPO1	R-spondin 1	11.0
22	WNT4	wingless-type MMTV integration site family, member 4	11.0	Publications
23	AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	11.0
24	LMX1B	LIM homeobox transcription factor 1, beta	11.0	Publications
25	ESRRB	estrogen-related receptor beta	11.0	Publications
26	CALM2	calmodulin 2 (phosphorylase kinase, delta)	11.0	Publications
27	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	11.0
28	CALM1	calmodulin 1 (phosphorylase kinase, delta)	11.0	Publications
29	AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	11.0
30	DMRT1	doublesex and mab-3 related transcription factor 1	11.0	Publications
31	TRRAP	transformation/transcription domain-associated protein	11.0	Publications
32	KRIT1	KRIT1, ankyrin repeat containing	11.0	Publications
33	CALM3	calmodulin 3 (phosphorylase kinase, delta)	11.0	Publications
34	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
35	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
36	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Publications
37	DOCK8	dedicator of cytokinesis 8	11.0	Publications
38	FGFR2	fibroblast growth factor receptor 2	11.0	Publications
39	ESR1	estrogen receptor 1	11.0	Publications
40	SOX11	SRY (sex determining region Y)-box 11	11.0	Publications
41	SOX3	SRY (sex determining region Y)-box 3	11.0	Publications
42	EVX2	even-skipped homeobox 2	11.0	Publications
43	PRKY	protein kinase, Y-linked, pseudogene	11.0
44	SOX10	SRY (sex determining region Y)-box 10	11.0	Publications
45	NDN	necdin homolog (mouse)	11.0	Publications
46	DLX2	distal-less homeobox 2	11.0	Publications
47	FOXL2	forkhead box L2	11.0	Publications
48	TSHB	thyroid stimulating hormone, beta	11.0	Publications
49	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
50	PAX6	paired box 6	11.0	Publications

Pathways related to sex reversal according to GeneDecks:

(show all 29)

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeleton remodeling RalB regulation pathway10	10.4	CALM3, CALM1, CALM2
2	Cytoskeleton remodeling_RalB regulation pathway41	10.4	CALM2, CALM3, CALM1
3	PLCG1 events in ERBB2 signaling38	10.4	CALM2, CALM3, CALM1
4	Immune response IFN gamma signaling pathway10	10.3	CALM3, CALM2, CALM1
5	Immune response_IFN gamma signaling pathway41	10.2	CALM1, CALM3, MAP3K1, CALM2
6	Development Angiotensin signaling via PYK210	10.2	CALM3, CALM2, CALM1, MAP3K1
7	Development_Angiotensin signaling via PYK241	10.2	CALM2, MAP3K1, CALM1, CALM3
8	Cytoskeleton remodeling_FAK signaling41	10.2	CALM2, MAP3K1, CALM3, CALM1
9	Long-term potentiation20	10.2	CALM3, CALM1, CALM2, PRKX
10	Cytoskeleton remodeling FAK signaling10	10.1	CALM1, CALM3, MAP3K1, CALM2
11	Melanogenesis20	10.1	CTNNB1, WNT4, PRKX, CALM2, CALM1, CALM3
12	Immune response CD28 signaling10	10.1	MAP3K1, CALM3, CALM1, CALM2
13	Gene Expression38	10.0	NR5A1, NR3C1, NR0B1, AR
14	Immune response_CD28 signaling41	10.0	CALM2, CALM1, CALM3, MAP3K1
15	Development Role of Activin A in cell differentiation and proliferation10	9.9	CYP11A1, CGA, NR5A1, STAR
16	Development_Role of Activin A in cell differentiation and proliferation41	9.9	CGA, CYP11A1, NR5A1, STAR
17	Gastric acid secretion20	9.9	PRKX, CALM3, CALM1, CALM2
18	Naphthalene metabolism41	9.9	AKR1C4, AKR1C2, AKR1C3
19	Naphthalene metabolism10	9.8	AKR1C2, AKR1C3, AKR1C4
20	Androgen Signaling36	9.8	CALM3, CALM2, CALM1, AR, SRY
21	Oocyte meiosis20	9.8	PRKX, CALM3, CALM2, AR, CALM1
22	nNOS Signaling at Neuronal Synapses36	9.8	CALM2, CALM3, CALM1
23	Development_Endothelin-1/EDNRA signaling41	9.7	CALM3, MAP3K1, CTNNB1, GATA4, CALM1, CALM2
24	Development Endothelin-1/EDNRA signaling10	9.7	GATA4, CTNNB1, CALM2, CALM1, CALM3, MAP3K1
25	GnRH signaling pathway20	9.6	CALM2, MAP3K1, PRKX, CALM1, CALM3, CGA
26	Steroid hormone biosynthesis20	9.3	AKR1C4, CYP11A1, CYP19A1, AKR1C2, AKR1C3
27	Transcription factors in neurogenesis10	8.9	NR5A1, DLX2, NDN, SOX10, PAX6, SOX11
28	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.7	CGA, AR, CYP19A1, NR3C1
29	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.6	CGA, CYP19A1, NR3C1, AR

Compounds related to sex reversal according to GeneDecks:

(show top 50)    (show all 103)

id	Compound	Score	Top Affiliating Genes
1	dmrt32	10.2	NR0B1, SRY, DMRT1, WT1, NR5A1, SOX9
2	chlordecone32	10.0	KRIT1, AKR1C4, AKR1C3, AKR1C2
3	bile acid32	10.0	AKR1C2, AKR1C3, NR1H2, AKR1C4
4	22r-hydroxycholesterol32	9.9	NR5A1, CYP11A1, CGA, STAR
5	geldanamycin32 9 9	11.6	AR, NR1H2, CTNNB1, ESR1
6	fluoxymesterone32 9 9	11.6	AR, NR3C1, ESR1
7	3alpha-hydroxysteroid32	9.6	AKR1C4, AKR1C3, AKR1C2, AR
8	flufenamic acid32 9 9	11.6	AKR1C4, AKR1C3, AKR1C2, AR
9	dihydroprogesterone32	9.5	AKR1C4, CYP11A1, CGA, AKR1C2, AKR1C3
10	gnrh32	9.3	CGB7, AR, MAP3K1, ESRRB, CYP11A1, CTNNB1
11	vinclozolin32	9.2	ESR1, CYP19A1, AR
12	4-hydroxytamoxifen32	9.2	ESR1, ESRRB, NR3C1, CYP19A1, CTNNB1, NR1H2
13	nandrolone32 18	10.1	AR, CYP19A1, NR3C1, ESR1
14	aminoglutethimide32 9 9	11.1	NR3C1, AR, CYP19A1, CYP11A1, ESR1
15	dhea32	9.1	CYP11A1, CYP19A1, STAR, NR5A1, AR, NR3C1
16	5-aza-2deoxycytidine32	9.0	TSPY1, AR, GATA4, NR5A1, NR1H2, FGFR2
17	cyproteroneacetate32	9.0	CYP19A1, CTNNB1, NR1H2, NR3C1, AR
18	prostaglandin32	9.0	STAR, ESRRB, CGA, AKR1C2, AKR1C3, AKR1C4
19	ribonucleic acid32	9.0	NR5A1, CGA, SOX9, STAR, WT1, TSHB
20	bicalutamide32 42 9 9	12.0	CTNNB1, AR, ESR1, CYP19A1, NR1H2
21	steroidal32	8.9	AR, ESR1, ESRRB, CYP19A1, NR1H2, NR3C1
22	ketoconazole32 42 9 18 9	12.9	NR3C1, CYP11A1, CYP19A1, NR1H2, AR
23	cyclic amp32 18	9.8	GATA4, SOX9, PRKX, STAR, KRIT1, NR5A1
24	retinoid32	8.8	TSHB, NR3C1, NR5A1, NR1H2, GATA4, AR
25	5alpha-androstane-3alpha,17beta-diol32	8.7	AKR1C2, AKR1C3, AR, AKR1C4, ESR1, CYP19A1
26	bisphenol a32	8.7	CYP19A1, AR, ESR1, NR1H2
27	letrozole32 42 9 9	11.6	AR, ESR1, CYP19A1, STAR, CGA
28	diethylstilbestrol32 9 9	10.6	CGA, AR, ESR1, CYP19A1, NR5A1, STAR
29	zinc32 18	9.6	NR5A1, WT1, SOX9, NR0B1, GATA4, SRY
30	flutamide32 9 9	10.5	ESR1, CGA, NR1H2, AR, CYP19A1
31	dehydroepiandrosterone sulfate32	8.5	CYP11A1, CYP19A1, NR5A1, CGA, AR
32	3beta-hydroxysteroid32	8.4	AKR1C2, CGA, AR, STAR, NR5A1, CYP19A1
33	progestins32	8.3	AR, CYP19A1, NR3C1, ESR1, NR1H2
34	estrone32 9 18 9	11.3	NR1H2, CYP19A1, AR, NR5A1, ESR1, AKR1C3
35	dexamethasone32 42 34 9 9	12.3	ESRRB, STAR, NR3C1, SOX9, KRIT1, NR1H2
36	progestin32	8.3	CYP11A1, CYP19A1, ESR1, CGA, NR1H2, NR3C1
37	mifepristone32 42 9 9	11.2	NR3C1, NR1H2, CTNNB1, ESR1, AR, CGA
38	androstenedione32 18	9.2	AKR1C2, AKR1C3, CGA, AR, CYP11A1, CYP19A1
39	17beta-hydroxysteroid32	8.0	STAR, CYP11A1, ESR1, CYP19A1, CGA, AR
40	tamoxifen32 34 9 9	10.9	CTNNB1, KRIT1, AR, CGA, FGFR2, NR1H2
41	vitamin d32	7.6	FGFR2, WT1, AR, NR5A1, NR3C1, NR1H2
42	vegf32	7.5	AKR1C3, WT1, ESR1, CTNNB1, AR, NR1H2
43	dihydrotestosterone32 9 18 9	10.5	CYP19A1, CYP11A1, ESR1, AKR1C4, AKR1C3, AKR1C2
44	doxorubicin32 34 9 9	10.3	WT1, NR3C1, CTNNB1, CYP19A1, GATA4, FGFR2
45	estradiol32 9 18 9	10.3	NR1H2, CYP19A1, CYP11A1, ESRRB, ESR1, AKR1C3
46	retinoic acid32 42 18	8.5	PAX6, GATA4, SOX9, NDN, TSHB, WT1
47	steroid32	5.9	CTNNB1, SRY, NR0B2, NR1H2, NR3C1, NR5A1
48	progesterone32 42 9 18 9	9.9	ESRRB, CYP11A1, CYP19A1, CTNNB1, NR0B1, NR1H2
49	estrogen32	5.7	MAP3K1, AKR1C3, FGFR2, AR, CGA, FGF9
50	testosterone32 9 18 9	8.6	MAP3K1, AKR1C2, AKR1C3, AKR1C4, ESR1, CYP11A1

Cellular components related to sex reversal according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:005654	8.1	KPNB1, WT1, NR5A1, NR3C1, NR1H2, NR0B2
2	nucleus	GO:005634	3.9	GATA4, SRY, CTNNB1, NR0B1, NR0B2, NR1H2

Biological processes related to sex reversal according to GeneDecks:

(show all 43)

id	Name	GO ID	Score	Top Affiliating Genes
1	male sex determination	GO:030238	10.6	SRY, NR0B1, FGF9, DMRT1
2	renal vesicle induction	GO:072034	10.5	WNT4, SOX9
3	positive regulation of mesenchymal cell proliferation	GO:002053	10.4	SOX9, FGFR2, FGF9, CTNNB1
4	limb bud formation	GO:060174	10.4	SOX11, FGFR2, SOX9
5	positive regulation of male gonad development	GO:2000020	10.4	SOX9, SRY, NR5A1, WT1
6	positive regulation of canonical Wnt receptor signaling pathway	GO:090263	10.3	RSPO1, FGF9, FGFR2, WNT4
7	negative regulation of female gonad development	GO:2000195	10.2	NR5A1, WT1
8	cellular response to jasmonic acid stimulus	GO:071395	10.2	AKR1C4, AKR1C3, AKR1C2
9	daunorubicin metabolic process	GO:044597	10.2	AKR1C3, AKR1C4, AKR1C2
10	doxorubicin metabolic process	GO:044598	10.2	AKR1C2, AKR1C3, AKR1C4
11	Sertoli cell differentiation	GO:060008	10.2	NR0B1, GATA4, DMRT1, SOX9
12	response to prostaglandin stimulus	GO:034694	10.2	AKR1C3, AKR1C2
13	regulation of timing of cell differentiation	GO:048505	10.2	FGF9, PAX6
14	sex determination	GO:007530	10.1	DMRT2, DMRT1, WT1, SOX3
15	granulosa cell differentiation	GO:060014	10.1	FOXL2, CYP11A1
16	intracellular receptor mediated signaling pathway	GO:030522	10.1	NR0B1, NR5A1, ESRRB, AR
17	pituitary gland development	GO:021983	10.1	PAX6, SOX3, NR0B1
18	sex differentiation	GO:007548	10.1	TSPY1, DMRT3, AR, SRY
19	positive regulation of neuroblast proliferation	GO:002052	10.1	PAX6, CTNNB1, SOX10
20	positive regulation of cardiac muscle cell proliferation	GO:060045	10.1	FGFR2, GATA4, FGF9
21	testosterone biosynthetic process	GO:061370	10.0	AKR1C3, CYP11A1
22	embryonic digestive tract morphogenesis	GO:048557	9.9	FGFR2, GATA4, SOX11
23	canonical Wnt receptor signaling pathway	GO:060070	9.9	GATA4, WNT4, RSPO1, CTNNB1
24	gonad development	GO:008406	9.8	CGA, WT1, NR0B1
25	response to estrogen stimulus	GO:043627	9.8	TSHB, GATA4, CYP11A1, ESR1
26	hypothalamus development	GO:021854	9.7	CYP19A1, NR0B1, SOX3
27	steroid biosynthetic process	GO:006694	9.7	CYP19A1, STAR, NR0B1
28	phthalate metabolic process	GO:018963	9.7	CYP11A1, CYP19A1
29	lacrimal gland development	GO:032808	9.7	FGFR2, PAX6
30	negative regulation of transcription, DNA-dependent	GO:045892	9.6	NR0B1, WNT4, FOXL2, CBX2, CTNNB1, NR1H2
31	transcription initiation from RNA polymerase II promoter	GO:006367	9.5	NR5A1, NR3C1, ESRRB, NR1H2, AR, NR0B2
32	cellular response to follicle-stimulating hormone stimulus	GO:071372	9.5	CYP11A1, GATA4, CYP19A1
33	biphenyl metabolic process	GO:018879	9.5	CYP19A1, CYP11A1
34	progesterone metabolic process	GO:042448	9.5	AKR1C3, AKR1C2, CYP19A1
35	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.4	DMRT1, FGFR2, NR0B1, CBX2, SOX11, WT1
36	adrenal gland development	GO:030325	9.4	NR5A1, NR0B1, NR3C1, CYP19A1, WNT4, WT1
37	steroid metabolic process	GO:008202	9.3	STAR, CYP19A1, CYP11A1, AKR1C4, AKR1C2, AKR1C3
38	in utero embryonic development	GO:001701	9.1	LMX1B, FGFR2, CTNNB1, SOX10, GATA4, KAT2A
39	positive regulation of cell proliferation	GO:008284	8.7	FGF9, FGFR2, CGA, AR, SOX9, AKR1C2
40	cell-cell signaling	GO:007267	8.6	CGA, FGFR2, WNT4, GATA4, NR5A1, FGF9
41	positive regulation of transcription, DNA-dependent	GO:045893	8.4	WT1, GATA4, WNT4, SOX9, SRY, CTNNB1
42	male gonad development	GO:008584	7.8	AKR1C3, AR, FGF9, DMRT2, CYP19A1, NR0B1
43	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.3	PAX6, CGA, FGFR2, ESR1, ESRRB, DMRT1

Molecular functions related to sex reversal according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	androsterone dehydrogenase activity	GO:047023	10.1	AKR1C3, AKR1C4
2	steroid hormone receptor activity	GO:003707	10.1	NR5A1, NR1H2, NR0B2, NR0B1, ESRRB, ESR1
3	androsterone dehydrogenase (A-specific) activity	GO:047026	10.0	AKR1C2, AKR1C3
4	oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	GO:016655	10.0	AKR1C4, AKR1C3, AKR1C2
5	steroid binding	GO:005496	10.0	ESRRB, ESR1, NR3C1
6	double-stranded DNA binding	GO:003690	9.9	NR5A1, NR3C1, NR0B1, CTNNB1, WT1
7	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	GO:003705	9.8	SRY, SOX10, SOX9, GATA4, NR5A1
8	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	9.8	ESRRB, NR0B1, AR, NR1H2, NR5A1
9	ketosteroid monooxygenase activity	GO:047086	9.8	AKR1C2, AKR1C3
10	RNA polymerase II core promoter sequence-specific DNA binding	GO:000979	9.8	PAX6, SOX3, SOX11
11	transcription coactivator activity	GO:003713	9.7	SOX10, NR5A1, CTNNB1, TRRAP, ESRRB, KAT2A
12	phenanthrene 9,10-monooxygenase activity	GO:018636	9.6	AKR1C2, AKR1C3
13	transcription factor binding	GO:008134	9.0	SRY, CTNNB1, NR0B1, GATA4, ESRRB, AR
14	chromatin binding	GO:003682	8.4	GATA4, ATRX, KAT2A, AR, CBX2, DLX2
15	sequence-specific DNA binding	GO:043565	8.1	GATA4, AR, ESRRB, DMRT2, NR0B1, EVX2
16	sequence-specific DNA binding transcription factor activity	GO:003700	7.4	AR, DLX2, DMRT2, DMRT1, EVX2, ESR1
17	DNA binding	GO:003677	7.4	FOXL2, SOX3, GATA4, NR1H2, NR0B2, NR0B1
18	protein binding	GO:005515	5.2	CBX2, CALM3, ESR1, FGFR2, AR, FOXL2