MCID: SHG001
MIFTS: 57

Shigellosis

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Shigellosis

MalaCards integrated aliases for Shigellosis:

Name: Shigellosis 12 72 49 55 51 3 14
Dysentery, Bacillary 41 69
Shigella Flexneri Infectious Disease 12
Shigella Boydii Infectious Disease 12
Shigella Sonnei Infectious Disease 12
Shigella Gastroenteritis 12
Bacillary Dysentery 12
Shigella Infections 69

Characteristics:

Orphanet epidemiological data:

55
shigellosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Shigellosis

NIH Rare Diseases : 49 Shigellosis is a disease caused by a group of bacteria called Shigella. Shigella is very contagious. Shigella germs are present in the stools of infected individuals for up to two weeks after symptoms have resolved. Individuals may be exposed through direct contact with an infected person or through contaminated food, water (both drinking and recreational water), or surfaces. Though anyone can get shigellosis, young children are most at risk. Symptoms of shigellosis usually begin one to two days after exposure and include diarrhea, abdominal pain, and fever. In otherwise healthy individuals, the symptoms usually resolve in 5-7 days. Those with mild shigellosis may need only rest and self-care measures to avoid dehydration (drinking fluids and electrolyte solutions). For more severe cases, antibiotics may be prescribed though some cases of shigellosis have been found to be resistant to antibiotics. Laboratory tests can be performed to determine which antibiotics are likely to be effective in an individual case. Most people make a full recovery, though it may take several months for bowel habits to return to normal. Complications are rare but may include post-infectious arthritis, bloodstream infections, seizures, or hemolytic-uremic syndrome (HUS). Last updated: 10/5/2016

MalaCards based summary : Shigellosis, also known as dysentery, bacillary, is related to dysentery and marasmus. An important gene associated with Shigellosis is CASP1 (Caspase 1), and among its related pathways/superpathways are ERK Signaling and Innate Immune System. The drugs Zinc and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and testes, and related phenotypes are cellular and hematopoietic system

CDC : 3 Shigellosis is an infectious disease caused by a group of bacteria called Shigella (shih-GEHL-uh). Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. Shigellosis usually resolves in 5 to 7 days. Some people who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others. The spread of Shigella can be stopped by frequent and careful handwashing with soap and taking other hygiene measures.

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in epithelium of colon, has material basis in Shigella boydii, has material basis in Shigella dysenteriae, has material basis in Shigella flexneri, or has material basis in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.

Wikipedia : 72 Shigellosis is a type of diarrhea caused by a bacterial infection with Shigella. Symptoms generally... more...

Related Diseases for Shigellosis

Diseases related to Shigellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 dysentery 30.1 CD79A LTF TTR
2 marasmus 29.7 CD79A TTR
3 acute diarrhea 29.3 CD79A LTF
4 meningitis 29.0 CXCL8 IL10 IRAK4
5 chlamydia 29.0 CASP1 CD79A CXCL8 IL10
6 israeli tick typhus 10.4 CASP1 CXCL8
7 streptococcal toxic-shock syndrome 10.4 CXCL8 LTA
8 exudative glomerulonephritis 10.3 CD79A CXCL8
9 tungiasis 10.3 CXCL8 IL10
10 scabies 10.3 CXCL8 IL10
11 acute transverse myelitis 10.3 CXCL8 IL10
12 erythema elevatum diutinum 10.3 CD79A CXCL8
13 felty syndrome 10.3 CXCL8 LTF
14 vulvovaginitis 10.3 CXCL8 IL10
15 wiskott-aldrich syndrome 10.2 CDC42 CTTN SRC
16 carotenemia 10.2 CD79A TTR
17 mycobacterium marinum 10.2 CAMP CXCL8
18 necatoriasis 10.2 CXCL8 IL10
19 trichomoniasis 10.2 CD79A CXCL8
20 giant papillary conjunctivitis 10.2 CXCL8 LTF
21 funisitis 10.2 CXCL8 IL10
22 blepharochalasis 10.2 CD79A TTR
23 transient hypogammaglobulinemia 10.2 IL10 LTA
24 salmonellosis 10.1
25 root caries 10.1 CD79A LTF
26 trichuriasis 10.1 CXCL8 IL10
27 cholera 10.1
28 haemophilus influenzae 10.1 CXCL8 LTF
29 sporotrichosis 10.1 CD79A IL10
30 obstructive jaundice 10.1 CD79A CXCL8 TTR
31 mucocutaneous leishmaniasis 10.1 IL10 LTA
32 parotitis 10.0 CD79A LTF
33 encephalopathy 10.0
34 idiopathic achalasia 10.0 IL10 LTA
35 osteomyelitis 10.0 CASP1 CXCL8 IL10
36 respiratory failure 10.0 CXCL8 IL10 TTR
37 tonsillitis 10.0 CD79A CXCL8 LTA
38 diarrhea 10.0
39 cow milk allergy 10.0 CD79A IL10
40 toxic shock syndrome 10.0 CXCL8 IL10 LTA
41 pouchitis 10.0 CXCL8 IL10 LTF
42 gingivitis 10.0 CD79A CXCL8 LTF
43 clonorchiasis 10.0 CD79A CXCL8 IL10
44 nasal cavity disease 9.9 CD79A CXCL8 IL10
45 nose disease 9.9 CD79A CXCL8 IL10
46 upper respiratory tract disease 9.9 CD79A CXCL8 IL10
47 extrinsic allergic alveolitis 9.9 CD79A CXCL8 IL10
48 bone inflammation disease 9.9 CD79A CXCL8 IL10
49 hemolytic-uremic syndrome 9.9
50 typhoid fever 9.9

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to Shigellosis

Symptoms & Phenotypes for Shigellosis

MGI Mouse Phenotypes related to Shigellosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 PFN1 SRC VCL CAMP CASP1 CD79A
2 hematopoietic system MP:0005397 9.65 SRC CAMP CASP1 CD79A CTTN IL10
3 immune system MP:0005387 9.32 SRC CAMP CASP1 CD79A CTTN IL10

Drugs & Therapeutics for Shigellosis

Drugs for Shigellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 3 7440-66-6 32051 23994
2
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173
3 Anti-Bacterial Agents Phase 3,Phase 2
4 Antibodies Phase 3
5 Immunoglobulins Phase 3
6 Vaccines Phase 3,Phase 1,Phase 2
7 Micronutrients Phase 3
8 Trace Elements Phase 3
9 Anti-Infective Agents Phase 3,Phase 2
10 Gastrointestinal Agents Phase 3,Phase 1
11 Nucleic Acid Synthesis Inhibitors Phase 3
12 rifamycin SV Phase 3
13 Rifamycins Phase 3
14 Shiga Toxins Phase 3
15
Histamine Approved, Investigational Phase 2 51-45-6, 75614-87-8 774
16
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
17 Antibiotics, Antitubercular Phase 2
18 Histamine Antagonists Phase 2
19
Histamine Phosphate Phase 2 51-74-1 65513
20 Neurotransmitter Agents Phase 2
21 Pharmaceutical Solutions Phase 2
22
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
23
Aluminum sulfate Approved Phase 1 10043-01-3
24 Adjuvants, Immunologic Phase 1
25 Antacids Phase 1
26 Anti-Ulcer Agents Phase 1
27
Formaldehyde Approved, Vet_approved 50-00-0 712
28 Disinfectants
29 Ether

Interventional clinical trials:

(show all 41)

# Name Status NCT ID Phase Drugs
1 Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in Israel Completed NCT00368316 Phase 3
2 Zinc Supplementation in Shigella Patients Completed NCT00321126 Phase 3 Children in the zinc group received 20 mg of elemental zinc as acetate per day in a twice-daily dose for two weeks.
3 Rifaximin for Prevention of Travellers' Diarrhea Completed NCT00742469 Phase 3 Rifaximin;Placebo
4 Improvements Through the Use of a Rapid Multiplex PCR Enteric Pathogen Detection Kit in Children With Hematochezia Not yet recruiting NCT03362970 Phase 3
5 Shigella Flexneri 2a Invaplex 50 Vaccine Dose Finding and Assessment of Protection Completed NCT00485134 Phase 1, Phase 2
6 Therapeutic Induction of Endogenous Antibiotics Completed NCT00800930 Phase 2
7 Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a Completed NCT02646371 Phase 2
8 A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan Adults Completed NCT02676895 Phase 2
9 Healthy Adult Volunteer Study for Two Doses of a Shigella Vaccine Completed NCT00210288 Phase 2
10 Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine Candidate Completed NCT01080716 Phase 1, Phase 2
11 Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIb Terminated NCT00866242 Phase 2
12 Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIa Terminated NCT00866476 Phase 2
13 Safety, Immunogenicity and Efficacy Study of Inactivated Whole Cell Shigella Flexneri 2a Vaccine With and Without dmLT in Adults Withdrawn NCT03038243 Phase 2
14 Shigella Sonnel O-SPC/rBRU Conjugate Vaccine Completed NCT01369927 Phase 1
15 A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults. Completed NCT02017899 Phase 1
16 Evaluate a New Shigella Sonnei Vaccine Administered Either by Intradermal, Intranasal or Intramuscular Route in Healthy Adults Completed NCT02034500 Phase 1
17 Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMP Completed NCT01531530 Phase 1
18 Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults Completed NCT01509846 Phase 1
19 Safety and Reactogenicity of Bioconjugate Vaccine to Prevent Shigella Completed NCT01069471 Phase 1
20 Safety and Immunogenicity of Two Live, Attenuated Oral Shigella Sonnei Vaccines: WRSs2 and WRSs3 Completed NCT01336699 Phase 1
21 Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2a Completed NCT02388009 Phase 1
22 A Study to Evaluate Safety and Immunogenicity of 1 Booster Dose of 1790GAHB Vaccine in Healthy Adults Primed With 3 Doses of 1790GAHB Vaccine in Study H03_01TP Compared to 1 Vaccination of 1790GAHB in Either Subjects Who Received Placebo in the Same Study Completed NCT03089879 Phase 1
23 Invaplex 50 Vaccine Dose-Ranging Completed NCT00082069 Phase 1
24 Effect of 15g Daily Consumption of NUTRIOSE on Healthy Volunteers Microbiota. Completed NCT01897649 Phase 1
25 Phase 1 Study of dmLT ID Vaccination in Healthy Adults Recruiting NCT02531685 Phase 1
26 Shigella Sonnei 53G Challenge Active, not recruiting NCT02816346 Phase 1
27 Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR) Administered Intranasally to Healthy, Adult Volunteers Active, not recruiting NCT02445963 Phase 1
28 Shigella WRSS1 Vaccine Trial in Bangladesh Active, not recruiting NCT02934178 Phase 1
29 SF2a-TT15 Conjugate Vaccine in Healthy Adult Volunteers Not yet recruiting NCT02797236 Phase 1
30 Shigella Sonnei OSPC-rDT Conjugate Vaccine Withdrawn NCT01399424 Phase 1 CP
31 Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli Infections Unknown status NCT01638039
32 A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty Hospitals Unknown status NCT01612572
33 Experimental Phage Therapy of Bacterial Infections Unknown status NCT00945087
34 The Long Term Clinical Course of Postinfectious Irritable Bowel Syndrome After Shigellosis; A 10 Year Follow up Study Completed NCT02516683
35 Safety Study of Live Shigella Vaccine in Bangladeshi Adults and Children Completed NCT01813071
36 Evaluation of a Diagnostic Enteric Card for Management of Diarrhea Completed NCT00736567
37 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
38 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies Recruiting NCT03349814
39 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
40 SaniVac Trial - Sanitation and Oral Rotavirus Vaccine Performance Recruiting NCT03313128
41 COmparison of MicroBiota AccordIng to Age in Crohn's Disease (COMeBACk) Recruiting NCT02839317

Search NIH Clinical Center for Shigellosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: dysentery, bacillary

Genetic Tests for Shigellosis

Anatomical Context for Shigellosis

The Foundational Model of Anatomy Ontology organs/tissues related to Shigellosis:

18
Epithelium Of Colon

MalaCards organs/tissues related to Shigellosis:

38
Colon, Testes, T Cells, Neutrophil, Appendix, Kidney, Brain

Publications for Shigellosis

Articles related to Shigellosis:

(show top 50) (show all 557)
# Title Authors Year
1
Heavy precipitation as a risk factor for shigellosis among homeless persons during an outbreak - Oregon, 2015-2016. ( 29217465 )
2018
2
An adult case with shigellosis-associated encephalopathy. ( 29351935 )
2018
3
Investigating the Geographic Distribution of Shigellosis Among Men and Women in Massachusetts: Possible Implications for Men Who Have Sex With Men. ( 29420446 )
2018
4
Disparities in severe shigellosis among adults - Foodborne diseases active surveillance network, 2002-2014. ( 29415691 )
2018
5
Brugada syndrome revealed by intestinal shigellosis in a patient from Benin at the University Hospital of Saint-Etienne. ( 28944419 )
2017
6
An 11-year study of shigellosis and Shigella species in Taiyuan, China: Active surveillance, epidemic characteristics, and molecular serotyping. ( 28188118 )
2017
7
Protection against shigellosis caused by Shigella dysenteriae serotype 4 in guinea pigs using Escherichia albertii DM104 as a live vaccine candidate strain. ( 28597684 )
2017
8
Shigellosis. ( 29256205 )
2017
9
Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country. ( 28321350 )
2017
10
Importation of travel-related infectious diseases is increasing in South Korea: An analysis of salmonellosis, shigellosis, malaria, and dengue surveillance data. ( 28919170 )
2017
11
Correspondence to invasive shigellosis in MSM. ( 28125923 )
2017
12
A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against<i>Shigella sonnei</i>Administered Intramuscularly to Adults from a Shigellosis-Endemic Country. ( 29375556 )
2017
13
What is the overlap between HIV and shigellosis epidemics in England: further evidence of MSM transmission? ( 28490580 )
2017
14
Seasonal and geographical distribution of bacillary dysentery (shigellosis) and associated climate risk factors in Kon Tam Province in Vietnam from 1999 to 2013. ( 28637484 )
2017
15
50 Years Ago in The Journal of Pediatrics: Double-Blind Treatment Study of Shigellosis Comparing Ampicillin, Sulfadiazine, and Placebo. ( 28746042 )
2017
16
Double-stranded RNA induces cathelicidin expression in the intestinal epithelial cells through phosphatidylinositol 3-kinase-protein kinase CIP-Sp1 pathway and ameliorates shigellosis in mice. ( 28343946 )
2017
17
An outbreak of shigellosis in a Children Welfare Institute caused by a multiple-antibiotic-resistant strain of Shigella flexneri 2a. ( 28189512 )
2017
18
Shigellosis. ( 29254859 )
2017
19
Notes from the Field: Shigellosis Outbreak Among Men Who Have Sex with Men and Homeless Persons - Oregon, 2015-2016. ( 27513523 )
2016
20
Recent Outbreaks of Shigellosis in California Caused by Two Distinct Populations of Shigella sonnei with either Increased Virulence or Fluoroquinolone Resistance. ( 28028547 )
2016
21
Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection Against Shigellosis in a Controlled Human Challenge Study. ( 27927680 )
2016
22
True Prevalence of Shigellosis in Indian Children with Acute Gastroenteritis: Have We Been Missing the Diagnosis? ( 27061990 )
2016
23
Shigellosis murine model established by intraperitoneal and intranasal route of administration: a comparative comprehension overview. ( 27664045 )
2016
24
Development of a live attenuated bivalent oral vaccine against Shigella sonnei shigellosis and typhoid fever. ( 27803169 )
2016
25
Shigellosis and Pregnancy in French Guiana: Obstetric and Neonatal Complications. ( 27114299 )
2016
26
Molecular Evaluation of High Fluoroquinolone Resistant Genes in Endemic Cases of Shigellosis, Northeast Part of Karnataka, India. ( 28283137 )
2016
27
A review of the public health management of shigellosis in Australia in the era of culture-independent diagnostic testing. ( 27774718 )
2016
28
Molecular Characterization of Shigella sonnei: An Increasingly Prevalent Etiologic Agent of Shigellosis in Guizhou Province, Southwest of China. ( 27195892 )
2016
29
Shigellosis in men who have sex with men: an overlooked opportunity to counsel with pre-exposure prophylaxis for HIV. ( 26945593 )
2016
30
Shigellosis: high rates of antibiotic resistance necessitate new treatment recommendations. ( 27078594 )
2016
31
Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome after Shigellosis: A 10-year Follow-up Study. ( 26908484 )
2016
32
Shigellosis. ( 27556171 )
2016
33
Shigellosis: Epidemiology in India. ( 27487999 )
2016
34
Shigellosis in Nepal: 13A years review of nationwide surveillance. ( 27814742 )
2016
35
A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity. ( 26918643 )
2016
36
Shigella sonnei bacteraemia occurring in a young man with shigellosis. ( 25920737 )
2015
37
Outbreak of Shigellosis in a Homeless Shelter With Healthcare Worker Transmission-British Columbia, April 2015. ( 26330023 )
2015
38
Microbiota that affect risk for shigellosis in children in low-income countries. ( 25625766 )
2015
39
Shigellosis in refugees, Austria, July to November 2015. ( 26676065 )
2015
40
Disparities of Shigellosis Rates among California Children by Race/Ethnicity and Census Tract Poverty Level, 2000-2010. ( 26020406 )
2015
41
Use of a culture-independent gastrointestinal multiplex PCR panel during a Shigellosis outbreak: considerations for clinical laboratories and public health. ( 25568430 )
2015
42
Shigellosis Outbreak in Al Batinah South Governorate, Oman: Case-control study. ( 26357558 )
2015
43
Invasive shigellosis in MSM. ( 26429891 )
2015
44
Shigella Infections in Household Contacts of Pediatric Shigellosis Patients in Rural Bangladesh. ( 26484778 )
2015
45
Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study. ( 25936611 )
2015
46
Intensified shigellosis epidemic associated with sexual transmission in men who have sex with men--Shigella flexneri and S. sonnei in England, 2004 to end of February 2015. ( 25953129 )
2015
47
Fulminant Shigellosis in a HIV Patient. ( 25821609 )
2015
48
Shigellosis in Subjects with Traveler's Diarrhea Versus Domestically Acquired Diarrhea: Implications for Antimicrobial Therapy and Human Immunodeficiency Virus Surveillance. ( 26195465 )
2015
49
Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. ( 24680068 )
2014
50
Report: prevalence of shigellosis in three different areas of Karachi. ( 24577930 )
2014

Variations for Shigellosis

Expression for Shigellosis

Search GEO for disease gene expression data for Shigellosis.

Pathways for Shigellosis

Pathways related to Shigellosis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 CDC42 CRK CXCL8 IL10 IRAK4 LTA
2
Show member pathways
13.66 CAMP CASP1 CD79A CDC42 CRK CXCL8
3
Show member pathways
13.17 CASP1 CRK CXCL8 IL10 IRAK4 LTA
4
Show member pathways
13.03 CASP1 CDC42 CRK CXCL8 IL10 LTA
5
Show member pathways
12.87 CAMP CASP1 CXCL8 IRAK4 SRC
6
Show member pathways
12.7 CDC42 CRK CTTN PFN1 SRC
7
Show member pathways
12.54 CDC42 CTTN SRC VCL
8
Show member pathways
12.48 CDC42 CRK PFN1 SRC VCL
9 12.47 CDC42 CRK PFN1 SRC VCL
10
Show member pathways
12.43 CDC42 CTTN PFN1 SRC
11 12.42 CDC42 CTTN PFN1 VCL
12
Show member pathways
12.33 CDC42 CRK IRAK4 SRC
13
Show member pathways
12.29 CDC42 CRK SRC VCL
14 12.09 CAMP IL10 IRAK4 SRC
15
Show member pathways
12.04 CXCL8 IL10 LTA
16
Show member pathways
11.89 CDC42 CRK SRC
17 11.79 CXCL8 IL10 VCL
18 11.78 CXCL8 IRAK4 LTA
19
Show member pathways
11.75 CDC42 SRC VCL
20 11.67 CASP1 CDC42 CXCL8 PFN1
21 11.63 CDC42 SRC VCL
22 11.58 CDC42 IRAK4 SRC
23 11.56 CRK CXCL8 SRC
24 11.5 CASP1 CXCL8 IL10 IRAK4
25 11.49 CDC42 CTTN SRC
26 11.47 CRK SRC VCL
27 11.45 CDC42 CRK SRC
28 11.27 CDC42 CTTN SRC
29 11.23 CDC42 CRK CTTN SRC VCL
30 11.05 CDC42 CRK SRC
31 10.98 CDC42 CRK CTTN SRC
32 10.98 CDC42 CRK CTTN CXCL8 PFN1 SRC
33 10.81 CTTN CXCL8 SRC

GO Terms for Shigellosis

Cellular components related to Shigellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 CAMP CDC42 CRK CTTN LTF PFN1
2 extracellular space GO:0005615 9.76 CAMP CXCL8 IL10 IRAK4 LTA LTF
3 specific granule lumen GO:0035580 9.43 CAMP LTF VCL
4 protein complex GO:0043234 9.43 CASP1 CDC42 CRK LTF TTR VCL
5 specific granule GO:0042581 9.4 CAMP LTF
6 podosome GO:0002102 8.8 CTTN SRC VCL
7 cytoplasm GO:0005737 10.15 CAMP CASP1 CD79A CDC42 CRK CTTN
8 extracellular region GO:0005576 10.03 CAMP CASP1 CXCL8 IL10 LTA LTF

Biological processes related to Shigellosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.61 CDC42 CRK SRC
2 ephrin receptor signaling pathway GO:0048013 9.5 CDC42 CRK SRC
3 regulation of protein binding GO:0043393 9.49 CRK SRC
4 innate immune response in mucosa GO:0002227 9.48 CAMP LTF
5 positive regulation of smooth muscle cell migration GO:0014911 9.46 CRK SRC
6 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.43 CDC42 CRK SRC
7 response to molecule of bacterial origin GO:0002237 9.4 CXCL8 IL10
8 epithelial cell-cell adhesion GO:0090136 9.37 CDC42 VCL
9 positive regulation of cytokine secretion GO:0050715 9.33 CASP1 IL10 SRC
10 negative regulation of growth of symbiont in host GO:0044130 9.13 CAMP IL10 LTA
11 cellular response to lipopolysaccharide GO:0071222 9.02 CAMP CASP1 CXCL8 IL10 SRC

Molecular functions related to Shigellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 8.92 CTTN PFN1 SRC VCL

Sources for Shigellosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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