MCID: SHG001
MIFTS: 63

Shigellosis malady

Infectious diseases, Gastrointestinal diseases categories

Summaries for Shigellosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Shigellosis is an infectious disease caused by a group of bacteria called Shigella. Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. The diarrhea is often bloody. Shigellosis usually resolves in 5 to 7 days. Persons with shigellosis in the United States rarely require hospitalization. A severe infection with high fever may be associated with seizures in children less than 2 years old. Some persons who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others.

MalaCards: Shigellosis, also known as shigella flexneri infectious disease, is related to meningitis and influenza. An important gene associated with Shigellosis is VCL (vinculin), and among its related pathways are PAK Pathway and Apoptosis Modulation and Signaling. The drugs loperamide and bismuth subcarbonate and the compounds pentoxifylline and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and breast.

Disease Ontology:8 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.

Wikipedia:63 Shigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is... more...

Aliases & Classifications for Shigellosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
shigellosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

shigellosis 8 42 10 44 48
shigella flexneri infectious disease 8
shigella boydii infectious disease 8
shigella sonnei infectious disease 8
shigella gastroenteritis 8
dysentery, bacillary 60
shigella infections 60
bacillary dysentery 8


External Ids:

Disease Ontology8 DOID:12385
MeSH34 D004405
ICD9CM27 004.9, 004
SNOMED-CT via Orphanet57 36188001, 111817006
ICD10 via Orphanet26 A03.0, A03.1, A03.2 A03.3, A03.8, A03.9, more

Related Diseases for Shigellosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Shigellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis29.8IL1B
2influenza29.8CASP1, LTA, LTF
3paratyphoid fever10.3
4dysentery10.3
5cholera10.3
6gastroenteritis10.3
7irritable bowel syndrome10.2
8hemolytic-uremic syndrome10.2
9diarrhea10.2
10reactive arthritis10.2
11arthritis10.2
12typhoid fever10.1
13hepatitis10.1
14acute diarrhea10.0
15campylobacteriosis10.0
16toxic encephalopathy10.0
17appendicitis10.0
18measles10.0
19listeriosis10.0
20hepatitis a10.0
21intestinal disease10.0
22pneumonia10.0
23septic shock10.0CASP1, LTA, LTF, IL1R1, IL1B
24periodontitis10.0LTA, LTF, IL1R1, IL1B
25familial cold autoinflammatory syndrome10.0IL1B, IL1R1, CASP1
26monocytic leukemia10.0CASP1, LTF, IL1R1, IL1B
27chronic infantile neurological cutaneous articular syndrome10.0IL1B, IL1R1, CASP1
28sepsis10.0IL1B, IL1R1, LTF, LTA, CASP1
29muckle-wells syndrome10.0CASP1, IL1R1, IL1B
30inflammatory bowel disease10.0CASP1, LTA, LTF, IL1R1, IL1B
31cerebral malaria10.0IL1R1, IL1B, VCL
32familial mediterranean fever10.0IL1B, CASP1, CARD17
33sjogren's syndrome10.0LTF
34cowpox10.0PFN3, CASP1, CARD17
35bacterial vaginosis10.0IL1B, IL1R1, LTF
36pulmonary fibrosis10.0IL1B
37synovitis10.0IL1B, IL1R1
38crohn's disease10.0LTF
39gingivitis10.0IL1B, LTF
40myocardial infarction10.0CASP1, VCL
41chorioamnionitis10.0IL1B, IL1R1, LTF
42pemphigus vulgaris10.0VCL
43mastitis10.0IL1B, LTF
44endometriosis10.0IL1B, IL1R1
45sarcoidosis10.0IL1B, LTA
46allergic rhinitis10.0PFN4
47ulcerative colitis10.0LTF
48alzheimer's disease10.0IL1B, CASP1
49arthropathy10.0IL1B
50tuberculosis10.0IL1B

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Clinical Features for Shigellosis

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Drugs & Therapeutics for Shigellosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Shigellosis:

32
Colon, Breast, T cells, Brain, Kidney, Testes, Appendix

FMA organs/tissues related to Shigellosis:

14
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

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Publications for Shigellosis

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Sources:
50PubMed
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Articles related to Shigellosis:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Gastrointestinal and extra-intestinal manifestations of childhood shigellosis in a region where all four species of Shigella are endemic. (23691156)
2013
2
Systemic shigellosis in South Africa. (22474223)
2012
3
Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases. (22606962)
2012
4
How we didn't clean up until we washed our hands: shigellosis in an elementary and middle school in North Texas. (22189658)
2012
5
Neurological manifestations of shigellosis in children in southwestern Iran. (22115119)
2012
6
Risk factors for sporadic shigellosis, FoodNet 2005. (20113209)
2010
7
An ecological analysis of sociodemographic factors associated with the incidence of salmonellosis, shigellosis, and E. coli O157:H7 infections in US counties. (18947443)
2009
8
Transmission risk factors and treatment of pediatric shigellosis during a large daycare center-associated outbreak of multidrug resistant Shigella sonnei: implications for the management of shigellosis outbreaks among children. (19738503)
2009
9
Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh. (17554249)
2008
10
An outbreak of multi-resistant Shigella sonnei in Australia: possible link to the outbreak of shigellosis in Denmark associated with imported baby corn from Thailand. (17900420)
2007
11
Rifaximin, a nonabsorbed oral antibiotic, prevents shigellosis after experimental challenge. (16586388)
2006
12
Shigellosis remains an important problem in children less than 5 years of age in Thailand. (15962553)
2005
13
Detection of Shigella by a PCR assay targeting the ipaH gene suggests increased prevalence of shigellosis in Nha Trang, Vietnam. (15131166)
2004
14
Conversion of Shigella flexneri serotype 2a to serotype Y in a shigellosis patient due to a single amino acid substitution in the protein product of the bacterial glucosyltransferase gtrII gene. (12892893)
2003
15
Shigellosis complicating preterm premature rupture of membranes resulting in congenital infection and preterm delivery. (12423805)
2002
16
Lethal encephalopathy complicating childhood shigellosis. (10412812)
1999
17
Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis. (9716056)
1998
18
Epidemiology of shigellosis among children exposed to cases of Shigella dysentery: a multivariate assessment. (9129527)
1997
19
Treatment of shigellosis: V. Comparison of azithromycin and ciprofloxacin. A double-blind, randomized, controlled trial. (9139555)
1997
20
Lack of reactivation of shigellosis in naturally infected enrofloxacin-treated cynomolgus monkeys after exogenous immunosuppression. (9433696)
1997
21
Semiquantitative estimation of Shigella antigen-specific antibodies: correlation with disease severity during shigellosis. (8920810)
1996
22
Convulsions in childhood shigellosis and antimicrobial resistance patterns of shigella isolates. (8701482)
1996
23
C reactive protein and prealbumin as markers of disease activity in shigellosis. (7590438)
1995
24
Cytokines in the stools of children with complicated shigellosis. (7583932)
1995
25
Short-term pefloxacin therapy in Madagascan children with shigellosis due to multiresistant organisms. (7888566)
1994
26
Immunopathological patterns in the rectal mucosa of patients with shigellosis: expression of HLA-DR antigens and T-lymphocyte subsets. (8024739)
1994
27
Is protection against shigellosis induced by natural infection with Plesiomonas shigelloides? (7910890)
1994
28
Potentials of Shigella flexneri Y strain TSF21 as a candidate vaccine against shigellosis: safety, immunogenicity and protective efficacy in Bonnet monkeys. (1878259)
1991
29
Prostacyclin concentrations in haemolytic uraemic syndrome after acute shigellosis in children. (1953009)
1991
30
Prospective study of the association between serum antibodies to lipopolysaccharide O antigen and the attack rate of shigellosis. (1706731)
1991
31
Intestinal obstruction during shigellosis: incidence, clinical features, risk factors, and outcome. (1860627)
1991
32
Shigellosis from swimming in a park pond in Michigan. (1905054)
1991
33
Response to antimicrobial therapy for shigellosis in Thailand. (2047660)
1991
34
Molecular pathogenesis of shigellosis: a review. (1779886)
1991
35
Houseflies (Musca domestica) as mechanical vectors of shigellosis. (1925289)
1991
36
Comparative efficacy of ceftriaxone and ampicillin for treatment of severe shigellosis in children. (2007941)
1991
37
A large outbreak of antibiotic-resistant shigellosis at a mass gathering. (2230262)
1990
38
Interspecies gene transfer in vivo producing an outbreak of multiply resistant shigellosis. (2685126)
1989
39
Clinical & bacteriological profiles of shigellosis in Calcutta before & after an epidemic (1984-87). (2674001)
1989
40
Comparison of single-dose treatment with norfloxacin and standard 5-day treatment with trimethoprim-sulfamethoxazole for acute shigellosis in adults. (2675757)
1989
41
Pathogenesis, genetics of virulence, and immunity in Shigellosis. (3138359)
1988
42
The epidemiology of shigellosis in Israel. (3052334)
1988
43
Further serological investigations in humans and domestic animals on the Cape Verde Islands (Q-fever, brucellosis, listeriosis, shigellosis, campylobacteriosis, yersiniosis, toxoplasmosis and chlamydia of PLT-group). (3139491)
1988
44
Shigellosis in Zaria, northern Nigeria. (3503400)
1987
45
Shigellosis--North Carolina. (3110573)
1987
46
Shigellosis (antibiotic resistance and transfer of R-factor). (3900357)
1985
47
Further data referring to oxolinic acid (Gramurin) treatment of shigellosis, salmonellosis and urinary tract infections. (6571200)
1984
48
Laboratory-acquired shigellosis. (6809196)
1982
49
Oral or intravenous trimethoprim-sulfamethoxazole therapy for shigellosis. (6981170)
1982
50
The differentiation of osmotic diarrhea from shigellosis. (1263492)
1976

Genetic Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Shigellosis

Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Shigellosis according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CASP1, MAPK12, LTA, IL1R1, IL1B, VCL
2
Hide members
10.5IL1R1, LTA, CASP1
310.5IL1R1, IL1B, VCL
4
Hide members
10.5IL1B, IL1R1, CASP1
5
Hide members
10.5CASP1, IL1R1, IL1B
610.5LTA, IL1R1, IL1B
7
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B, VCL
8
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
9
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
10
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
1110.5IL1B, CASP1
1210.5ARPC4, ARPC5L, RHOG, VCL
13
Hide members
10.5ARPC4, ARPC5L, PFN4, PFN3, VCL
14
Hide members
10.5CASP1, ARPC4, MAPK12, MAPK13, VASP, IL1R1
15
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1B
16
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1B
17
Hide members
10.5CASP1, MAPK12, MAPK13, IL1R1, IL1B
18
Hide members
10.5CASP1, MAPK12, MAPK13, IL1R1, IL1B
19
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B
20
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B
2110.5IL1B, CASP1, PFN3, PFN4, MAPK13, MAPK12
22
Hide members
10.5CASP1, MAPK12, MAPK13, LTA
2310.5ARPC4, ARPC5L, VASP
2410.5ARPC4, ARPC5L, RHOG, MAPK12, MAPK13, PFN4
25
Immune response IFN gamma signaling pathway
Hide members
10.5CASP1, MAPK12, MAPK13, IL1B
26
Hide members
10.5IL1B, MAPK13, MAPK12, CASP1
2710.5IL1B, MAPK13, MAPK12, CASP1
2810.5MAPK12, MAPK13, LTA, IL1B
29
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
30
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
31
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
3210.5MAPK12, MAPK13, IL1R1, IL1B
33
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
3410.5VCL, VASP, MAPK13, MAPK12
35
Hide members
10.5VCL, VASP, MAPK13, MAPK12
36
Hide members
10.5MAPK13, MAPK12, CASP1
37
Hide members
10.5MAPK13, MAPK12, CASP1
38
Hide members
10.5MAPK13, MAPK12, CASP1
3910.5MAPK12, MAPK13, IL1B
4010.5MAPK13, MAPK12
4110.5MAPK13, MAPK12
4210.5MAPK12, MAPK13
4310.5MAPK13, MAPK12, ARPC4

Compounds for genes affiliated with Shigellosis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Shigellosis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.9IL1B, IL1R1, LTF, LTA, CASP1
2endotoxin4410.9CASP1, LTA, LTF, IL1R1, IL1B
3tenidap44 2811.9LTF, IL1R1, IL1B
4neopterin4410.9LTA, LTF, IL1R1, IL1B
5anakinra44 1111.9IL1B, IL1R1, CASP1
6indomethacin44 59 28 1113.9LTA, LTF, VASP, IL1R1, IL1B
7as 10159 4411.9IL1B, IL1R1, CASP1
8minocycline44 1111.9CASP1, LTF, IL1B
9actinomycin d4410.9CASP1, LTA, LTF, IL1R1, IL1B
10cuprophan4410.9IL1B, IL1R1, CASP1
11acetyl-tyr-val-ala-asp-cho4410.9CASP1, IL1B
12lipoteichoic acid4410.9IL1B, IL1R1, LTA
13hyaluronic acid44 2411.9IL1B, IL1R1, LTF, LTA
14sb 20358044 5911.9IL1B, IL1R1, MAPK13, MAPK12, CASP1
15vegf4410.9CASP1, LTA, LTF, IL1R1, IL1B, VCL
16serine4410.9CASP1, MAPK12, MAPK13, LTA, LTF, VASP
17etanercept44 49 1112.9LTA, IL1R1, IL1B
18pge24410.9CASP1, LTA, LTF, IL1R1, IL1B
19il 104410.9LTA, IL1R1, IL1B
20nitric oxide44 11 2412.9CASP1, LTA, VASP, IL1R1, IL1B, VCL
21infliximab44 49 1112.9IL1B, IL1R1, LTA
22diphenyleneiodonium4410.8IL1B, IL1R1, CASP1
23peptidoglycan44 2811.8CASP1, IL1R1, IL1B
24threonine4410.8CASP1, MAPK12, LTA, VASP, IL1R1, VCL
25ivig4410.8IL1B, IL1R1, LTA
26aspirin44 49 28 2413.8CASP1, VASP, IL1R1, IL1B
27cycloheximide4410.8CASP1, LTA, IL1R1, IL1B, VCL
28ibuprofen44 28 49 11 2414.8IL1B, IL1R1, LTF
29n acetylcysteine4410.8IL1B, IL1R1, LTF, CASP1
30tlck4410.8CASP1, IL1B
3112-o-tetradecanoylphorbol 13-acetate4410.7MAPK13, LTA, IL1R1, VCL
32muramyl dipeptide44 2811.7CASP1, IL1B
33ag-1264410.7CASP1, IL1B
34h2o24410.7CASP1, LTA, LTF, IL1R1, VCL
35monosodium urate4410.7IL1R1, IL1B
36fibrinogen4410.7VCL, IL1R1, VASP, LTF
37leukotriene b444 59 2412.6LTF, IL1R1, IL1B
38toxin-14410.6LTA, IL1B
394-ipp5910.5IL1R1, IL1B
40gold sodium thiomalate4410.5IL1B, IL1R1
41git 275910.4IL1R1, IL1B
42cytochalasin4410.2LTF, VCL

GO Terms for genes affiliated with Shigellosis

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Sources:
16Gene Ontology
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Cellular components related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.5ARPC4, RHOG, MAPK12, MAPK13, BLOC1S3, VASP
2cytoskeletonGO:00585610.2VCL, PFN3, PFN4, ARPC5L, CCIN

Biological processes related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.5IL1B, CASP1
2cellular response to organic substanceGO:07131010.5IL1B, CASP1
3lymph node developmentGO:04853510.4CD248, LTA
4response to ATPGO:03319810.2IL1B, CASP1

Molecular functions related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase activityGO:00470710.5MAPK13, MAPK12
2actin bindingGO:00377910.2VCL, VASP, PFN3, PFN4, ARPC5L

Products for genes affiliated with Shigellosis

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  • Antibodies
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Sources for Shigellosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet