MCID: SHG001
MIFTS: 65

Shigellosis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories

Summaries for Shigellosis

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Sources:
9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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CDC:4 Shigellosis is an infectious disease caused by a group of bacteria called Shigella. Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. The diarrhea is often bloody. Shigellosis usually resolves in 5 to 7 days. Persons with shigellosis in the United States rarely require hospitalization. A severe infection with high fever may be associated with seizures in children less than 2 years old. Some persons who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others.

MalaCards: Shigellosis, also known as shigella flexneri infectious disease, is related to arthritis and septic shock. An important gene associated with Shigellosis is CASP1 (caspase 1, apoptosis-related cysteine peptidase), and among its related pathways are TRAF Pathway and Legionellosis. The drugs loperamide and bismuth subcarbonate and the compounds acetyl-tyr-val-ala-asp-cho and tlck have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and breast, and related mouse phenotypes are immune system and cardiovascular system.

Disease Ontology:9 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.

Wikipedia:66 Shigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is... more...

Aliases & Classifications for Shigellosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 64UMLS via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

50
shigellosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

shigellosis 9 44 11 46 50
shigella flexneri infectious disease 9
shigella sonnei infectious disease 9
shigella boydii infectious disease 9
shigella gastroenteritis 9
dysentery, bacillary 63
shigella infections 63
bacillary dysentery 9


External Ids:

Disease Ontology9 DOID:12385
MeSH36 D004405
ICD9CM28 004.9, 004
UMLS via Orphanet64 C0013371
SNOMED-CT via Orphanet60 36188001, 111817006
ICD10 via Orphanet27 A03.0, A03.1, A03.2 A03.3, A03.8, A03.9, more

Related Diseases for Shigellosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Shigellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.3IL1R1, IL1B, CASP1, LTA, LTF
2septic shock30.2LTF, LTA, CASP1, IL1B, IL1R1
3sepsis30.1LTF, LTA, CASP1, IL1B, IL1R1
4influenza30.0LTF, LTA, CASP1
5blindness10.5
6paratyphoid fever10.4
7dysentery10.4
8cholera10.3
9gastroenteritis10.3
10irritable bowel syndrome10.2
11hemolytic-uremic syndrome10.2
12diarrhea10.2
13reactive arthritis10.2
14typhoid fever10.2
15hepatitis10.2
16periodontitis10.1IL1B
17periodontal disease10.1LTF
18acute graft versus host disease10.1IL1R1, LTA
19appendicitis10.1
20measles10.1
21listeriosis10.1
22hepatitis a10.1
23acute diarrhea10.1
24campylobacteriosis10.1
25toxic encephalopathy10.1
26pneumonia10.1
27bacteremia10.1
28juvenile rheumatoid arthritis10.1LTA, IL1R1
29myocardial infarction10.1CASP1, VCL
30toxic shock syndrome10.1IL1B, LTA
31adult respiratory distress syndrome10.1LTA, IL1B
32mastitis10.1IL1B, LTF
33gingivitis10.1LTF, IL1B
34otitis media10.1LTF, IL1B
35familial cold autoinflammatory syndrome10.1IL1R1, IL1B, CASP1
36chronic infantile neurological cutaneous articular syndrome10.0IL1R1, IL1B, CASP1
37uveitis10.0LTA, IL1R1
38muckle-wells syndrome10.0CASP1, IL1B, IL1R1
39type 1 diabetes mellitus10.0IL1R1, IL1B, LTA
40cerebral malaria10.0VCL, IL1R1, IL1B
41bacterial vaginosis10.0IL1R1, IL1B, LTF
42chorioamnionitis10.0LTF, IL1B, IL1R1
43pancreatitis10.0IL1B, CASP1, LTF
44graft versus host disease10.0IL1R1, LTA
45systemic lupus erythematosus10.0IL1R1, LTA, LTF
46familial mediterranean fever10.0CASP1, CARD17, IL1B
47multiple sclerosis10.0LTA, CASP1, IL1B, IL1R1
48monocytic leukemia10.0IL1R1, IL1B, CASP1, LTF
49stomach cancer10.0IL1R1, IL1B, CASP1, LTA
50cowpox10.0PFN3, CARD17, CASP1

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Symptoms for Shigellosis

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Drugs & Therapeutics for Shigellosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Shigellosis:

34
Colon, Breast, T cells, Brain, Kidney, Testes, Appendix

FMA organs/tissues related to Shigellosis:

15
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Shigellosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5LTF, LTA, RHOG, CASP1, IL1B, IL1R1
2MP:00053858.2LTA, CASP1, IL1B, IL1R1, VASP, VCL
3MP:00053978.0LTA, RHOG, CASP1, IL1B, IL1R1, VASP
4MP:00036318.0RHOG, CASP1, IL1B, IL1R1, VASP, LTA

Publications for Shigellosis

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Sources:
53PubMed
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Articles related to Shigellosis:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Use of population-based surveillance to define the high incidence of shigellosis in an urban slum in Nairobi, Kenya. (23505506)
2013
2
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. (23775017)
2013
3
Systemic shigellosis in South Africa. (22474223)
2012
4
Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases. (22606962)
2012
5
How we didn't clean up until we washed our hands: shigellosis in an elementary and middle school in North Texas. (22189658)
2012
6
A 9-year study of shigellosis in Northeast Malaysia: Antimicrobial susceptibility and shifting species dominance. (21654922)
2011
7
Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia. (21029529)
2010
8
Risk factors for sporadic shigellosis, FoodNet 2005. (20113209)
2010
9
Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh. (17554249)
2008
10
Comparison of cost-of-illness with willingness-to-pay estimates to avoid shigellosis: evidence from China. (18234703)
2008
11
Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the Peruvian Amazon. (18710884)
2008
12
High prevalence of CTX-M-15 extended-spectrum beta-lactamase among contacts of patients with shigellosis due to Shigella flexneri carrying CTX-M-15. (17646198)
2007
13
Risk factors for shigellosis in Thailand. (16997593)
2006
14
Azithromycin as an alternative to nalidixic acid in the therapy of childhood shigellosis. (15071299)
2004
15
Acceptability and accessibility of a Shigellosis vaccine in Nha Trang city of Viet Nam. (15473518)
2004
16
Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development. (15030306)
2003
17
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase. (11178905)
2001
18
Disease-dependent changes in T-cell populations in patients with shigellosis. (10843411)
2000
19
Pathogenesis of shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation and vaccine development. (10211438)
1998
20
Double-blind, randomized clinical trial for safety and efficacy of norfloxacin for shigellosis in children. (9099325)
1997
21
Pathogenesis and immune responses in shigellosis. (8993387)
1996
22
Shigellosis: from molecular pathogenesis of infection to protective immunity and vaccine development. (9127893)
1996
23
Shigellosis in Thai children: experience from a rural hospital 1985-1993. (8629073)
1995
24
Epidemiological, clinical and microbiological features of shigellosis among hospitalized children in northern Israel. (7660077)
1995
25
Shigellosis in children: clinical and laboratory features. (8904140)
1995
26
Short-term pefloxacin therapy in Madagascan children with shigellosis due to multiresistant organisms. (7888566)
1994
27
Moose soup shigellosis in Alaska. (8048226)
1994
28
Pathology of shigellosis and its complications. (8144144)
1994
29
An outbreak of shigellosis in a slum colony of Delhi-1990. (8014439)
1993
30
Evaluation of an intervention program for the control of an outbreak of shigellosis among institutionalized persons. (8228351)
1993
31
Shigellosis complicated by perforated appendix. (8483634)
1993
32
Shigellosis in Thai children: epidemiologic, clinical and laboratory features. (1565537)
1992
33
From the Centers for Disease Control. Shigellosis in child day care centers--Lexington-Fayette County, Kentucky, 1991. (1640601)
1992
34
Shigellosis-associated encephalopathy. (1408493)
1992
35
Efficacy of norfloxacin for shigellosis: a double-blind randomised clinical trial. (1430968)
1992
36
Evaluation of indigenous plants in the treatment of acute shigellosis. (1816661)
1991
37
Potentials of Shigella flexneri Y strain TSF21 as a candidate vaccine against shigellosis: safety, immunogenicity and protective efficacy in Bonnet monkeys. (1878259)
1991
38
An outbreak of shigellosis aboard a cruise ship caused by a multiple-antibiotic-resistant strain of Shigella flexneri. (1652203)
1991
39
Shigellosis. (1861289)
1991
40
The use of hygiene, cohorting, and antimicrobial therapy to control an outbreak of shigellosis. (2405639)
1990
41
Single-dose ciprofloxacin for shigellosis. (1971401)
1990
42
Death in shigellosis: incidence and risk factors in hospitalized patients. (2313128)
1990
43
Recurrent shigellosis complicating human immunodeficiency virus infection: failure of pre-existing antibodies to confer protection. (2642653)
1989
44
Plasmid profile as a useful marker of a Shigella dysenteriae type 1 strain causing an epidemic of shigellosis. (3077946)
1988
45
A shigellosis outbreak traced to commercially distributed shredded lettuce. (3057879)
1988
46
Leads from the MMWR. Multiply resistant shigellosis in a day-care center--Texas. (3540326)
1987
47
Shigellosis in children. (3428993)
1987
48
Comparative efficacies of single intravenous doses of ceftriaxone and ampicillin for shigellosis in a placebo-controlled trial. (3518625)
1986
49
The relation between production of cytotoxin and clinical features in shigellosis. (3519788)
1986
50
Incidence of shigellosis among paediatric diarrhoeal disorders (a bacteriological study). (6491334)
1984

Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Shigellosis

Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Sources:
51PathCards, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems, 56Reactome, 61Thomson Reuters
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Pathways related to Shigellosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9LTA, CASP1
29.8CASP1, IL1B
39.8IL1B, CASP1
49.8LTA, IL1B
5
Show member pathways
IL27-mediated signaling events39
9.8LTA, IL1B
6
Show member pathways
Serotonin Transporter Activity39
9.8IL1B, IL1R1
79.7VASP, VCL
8
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.6IL1R1, CASP1, LTA
9
Show member pathways
9.6VCL, CASP1, LTA
10
Show member pathways
9.6LTA, CASP1, IL1B
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.5CASP1, IL1B, IL1R1
12
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
9.5IL1R1, IL1B, CASP1
13
Show member pathways
MAPK signaling pathway39
9.5IL1R1, IL1B, CASP1
14
Show member pathways
9.5LTA, IL1B, IL1R1
15
Show member pathways
9.5LTA, IL1B, IL1R1
169.5IL1R1, IL1B, LTA
17
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.5IL1R1, IL1B, LTA
189.5IL1B, IL1R1, VCL
19
Show member pathways
9.3IL1R1, IL1B, CASP1, LTA
20
Show member pathways
9.3IL1R1, IL1B, CASP1, LTA
219.2ARPC5L, RHOG, VCL
22
Show member pathways
9.0IL1B, CARD17, CASP1
23
Show member pathways
8.9LTA, CASP1, IL1B, IL1R1, VCL
24
Show member pathways
8.9PFN3, PFN4, VASP
25
Show member pathways
8.7IL1R1, IL1B, CARD17, CASP1
26
Show member pathways
8.7CASP1, CARD17, IL1B, IL1R1
27
Show member pathways
8.5ARPC5L, VCL, PFN4, PFN3
28
Show member pathways
7.4ARPC5L, PFN3, PFN4, VCL, IL1B, CASP1

Compounds for genes affiliated with Shigellosis

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Sources:
46Novoseek, 30IUPHAR, 52PharmGKB, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB
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Compounds related to Shigellosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1acetyl-tyr-val-ala-asp-cho4610.2IL1B, CASP1
2tlck4610.1CASP1, IL1B
3ag-1264610.1CASP1, IL1B
4muramyl dipeptide46 3011.1CASP1, IL1B
5monosodium urate4610.1IL1R1, IL1B
6toxin-14610.0LTA, IL1B
7cytochalasin4610.0VCL, LTF
8rabeprazole46 52 25 1213.0IL1B, LTF
9git 276210.0IL1R1, IL1B
10anakinra46 1211.0IL1R1, CASP1, IL1B
11as 10146 6211.0IL1R1, CASP1, IL1B
12cuprophan4610.0IL1R1, CASP1, IL1B
134-ipp6210.0IL1R1, IL1B
14lipoteichoic acid469.9IL1R1, IL1B, LTA
15diphenyleneiodonium469.9IL1R1, IL1B, CASP1
16etanercept46 52 1211.9IL1R1, IL1B, LTA
17minocycline46 1210.9LTF, IL1B, CASP1
18gold sodium thiomalate469.9IL1B, IL1R1
19peptidoglycan46 3010.9CASP1, IL1R1, IL1B
20il 10469.9IL1R1, LTA, IL1B
21tenidap46 3010.9IL1B, LTF, IL1R1
22infliximab46 52 1211.9IL1R1, IL1B, LTA
23ivig469.9LTA, IL1B, IL1R1
24ibuprofen46 30 52 25 1213.8LTF, IL1R1, IL1B
25leukotriene b446 62 2511.8IL1R1, IL1B, LTF
26hydrocortisone46 3 62 1212.7IL1B, IL1R1, LTF
27neopterin469.6LTF, LTA, IL1B, IL1R1
28cyclosporin a46 30 6211.6IL1R1, LTF, LTA, CASP1
29mannose469.6LTF, LTA, VCL
30hyaluronic acid46 2510.6IL1B, LTA, LTF, IL1R1
31n acetylcysteine469.6IL1B, IL1R1, CASP1, LTF
32phosphatidylserine46 30 1211.5VCL, CASP1, LTF
33pirfenidone46 6210.5IL1R1, IL1B
34aspirin46 52 30 2512.5VASP, IL1R1, IL1B, CASP1
35fmlp469.5IL1B, LTA, LTF
36fibrinogen469.4VASP, IL1R1, LTF, VCL
37pentoxifylline46 1210.4CASP1, IL1R1, IL1B, LTA, LTF
38endotoxin469.4LTA, IL1B, CASP1, IL1R1, LTF
39h2o2469.4IL1R1, LTF, LTA, VCL, CASP1
40actinomycin d469.3LTF, LTA, CASP1, IL1B, IL1R1
41cycloheximide469.3IL1R1, IL1B, CASP1, LTA, VCL
42pge2469.3IL1R1, IL1B, CASP1, LTA, LTF
43dexamethasone46 52 30 1212.3LTF, LTA, CASP1, IL1B, IL1R1
44retinoic acid46 2510.2LTA, CASP1, IL1B, LTF, IL1R1
45prostacyclin469.2LTF, IL1B, VASP
46threonine469.2VASP, CASP1, LTA, VCL, IL1R1
47indomethacin46 30 62 1212.2LTF, LTA, IL1B, IL1R1, VASP
48vegf469.0LTA, CASP1, LTF, IL1B, IL1R1, VCL
49nitric oxide46 25 1210.9IL1B, CASP1, VCL, VASP, IL1R1, LTA
50serine468.8VCL, LTA, LTF, CASP1, IL1R1, VASP

GO Terms for genes affiliated with Shigellosis

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Sources:
17Gene Ontology
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Cellular components related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6VCL, IL1R1, IL1B, CASP1, LTF
2extracellular vesicular exosomeGO:0700628.4ARPC5L, LTF, RHOG, VASP, VCL
3cytoskeletonGO:0058568.4ARPC5L, VCL, PFN4, PFN3

Biological processes related to Shigellosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.0CASP1, IL1B
2regulation of inflammatory responseGO:0507279.9CASP1, IL1R1
3response to ATPGO:0331989.9CASP1, IL1B
4cellular response to organic substanceGO:0713109.7CASP1, IL1B
5positive regulation of interferon-gamma productionGO:0327299.5LTA, IL1B
6positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.5IL1B, CASP1, LTF
7actin cytoskeleton organizationGO:0300369.0RHOG, PFN4, PFN3

Molecular functions related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:0037798.0ARPC5L, VASP, VCL, PFN4, PFN3

Products for genes affiliated with Shigellosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Shigellosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet