MCID: SHG001
MIFTS: 53

Shigellosis malady

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Shigellosis

About this section
Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Shigellosis:

Name: Shigellosis 11 48 54 50 2 13
Dysentery, Bacillary 39 68
Shigella Flexneri Infectious Disease 11
Shigella Sonnei Infectious Disease 11
 
Shigella Boydii Infectious Disease 11
Shigella Gastroenteritis 11
Bacillary Dysentery 11
Shigella Infections 68

Characteristics:

Orphanet epidemiological data:

54
shigellosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:12385
MeSH39 D004405
Orphanet54 ORPHA810
ICD10 via Orphanet31 A03.8, A03.9, A03.0 A03.2, A03.1, A03.3, more
UMLS via Orphanet69 C0013371

Summaries for Shigellosis

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NIH Rare Diseases:48 Shigellosis is a disease caused by a group of bacteria called Shigella. Shigella is very contagious. Shigella germs are present in the stools of infected individuals for up to two weeks after symptoms have resolved. Individuals may be exposed through direct contact with an infected person or through contaminated food, water (both drinking and recreational water), or surfaces. Though anyone can get shigellosis, young children are most at risk. Symptoms of shigellosis usually begin one to two days after exposure and include diarrhea, abdominal pain, and fever. In otherwise healthy individuals, the symptoms usually resolve in 5-7 days. Those with mild shigellosis may need only rest and self-care measures to avoid dehydration (drinking fluids and electrolyte solutions). For more severe cases, antibiotics may be prescribed though some cases of shigellosis have been found to be resistant to antibiotics. Laboratory tests can be performed to determine which antibiotics are likely to be effective in an individual case. Most people make a full recovery, though it may take several months for bowel habits to return to normal. Complications are rare but may include post-infectious arthritis, bloodstream infections, seizures, or hemolytic-uremic syndrome (HUS). Last updated: 10/5/2016

MalaCards based summary: Shigellosis, also known as dysentery, bacillary, is related to flinders island spotted fever and maligant granulosa cell tumor of ovary. An important gene associated with Shigellosis is CASP1 (Caspase 1), and among its related pathways are Atypical NF-kappaB pathway and Signaling events mediated by VEGFR1 and VEGFR2. The drugs loperamide hydrochloride and bismuth hydroxide have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and t cells, and related mouse phenotypes are cardiovascular system and neoplasm.

Disease Ontology:11 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in Shigella boydii, has material basis in Shigella dysenteriae, has material basis in Shigella flexneri, or has material basis in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted by ingestion of food and water contaminated with feces.

Wikipedia:71 Shigellosis, also known as bacillary dysentery or Marlow syndrome, in its most severe manifestation, is... more...

Related Diseases for Shigellosis

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Diseases related to Shigellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1flinders island spotted fever10.4CASP1, CXCL8
2maligant granulosa cell tumor of ovary10.4CXCL8, LTA
3basidiobolomycosis10.3CXCL8, IL10
4gonadal disease10.3CXCL8, IL10
5focal embolic glomerulonephritis10.3CD79A, CXCL8
6acute interstitial pneumonia10.3CXCL8, IL10
7benign adult familial myoclonic epilepsy10.3CXCL8, IL10
8lymphangiectasia, intestinal10.2CXCL8, LTF
9infancy electroclinical syndrome10.2CXCL8, IL10
10cervical incompetence10.2CDC42, CXCL8
11chromophil adenoma of the kidney10.2IL10, LTA
12hypervitaminosis d10.2CD79A, TTR
13fallopian tube disease10.2CD79A, CXCL8
143-alpha hydroxyacyl-coa dehydrogenase deficiency10.1CXCL8, LTF
15hematocele of tunica vaginalis testis10.1CD79A, TTR
16plague10.1CD79A, TTR
17diversion colitis10.1CDC42, LTF
18neurotic excoriation10.0IL10, LTA
19pleomorphic lipoma10.0CASP1, CXCL8, IL10
20boutonneuse fever10.0CD79A, LTF
21cholera10.0
22common cold10.0CXCL8, IL10, LTA
23bacteriuria10.0CXCL8, IL10, LTA
24sialadenitis10.0CD79A, LTF
25dysentery10.0
26extrahepatic cholestasis10.0CD79A, CXCL8, TTR
27pseudoretinitis pigmentosa10.0CXCL8, IL10, LTF
28ankylosis9.9CD79A, CXCL8
29diarrhea9.9
30encephalopathy9.9
31addison's disease9.9CD79A, CXCL8, IL10
32crustacean allergy9.9CD79A, IL10
33kidney angiomyolipoma9.9CD79A, CXCL8, IL10
34vaginitis9.9CD79A, CXCL8, IL10
35geotrichosis9.9CD79A, CXCL8, IL10
36biliary tract disease9.9CD79A, CXCL8, IL10
37bone lymphoma9.9CD79A, TTR
38chronic hiccups9.9CD79A, IL10
39hemorrhagic fever with renal syndrome9.8CD79A, CXCL8, IL10
40xanthomatosis9.8CD79A, CXCL8, IL10
41hemolytic-uremic syndrome9.8
42typhoid fever9.8
43rectum leiomyosarcoma9.8CD79A, CXCL8, IL10
44laryngeal tuberculosis9.8CD79A, CXCL8, IL10
45hodgkin's lymphoma, mixed cellularity9.8CD79A, CXCL8, IL10
46congenital disorder of glycosylation, type ih9.8CD79A, CXCL8, IL10
47perianal skin paget's disease9.8CD79A, CXCL8, IL10
48palmoplantar keratosis9.8CD79A, CXCL8, IL10
49basaloid squamous cell carcinoma9.8CD79A, CXCL8, IL10
50hepatitis9.8

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Symptoms & Phenotypes for Shigellosis

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MGI Mouse Phenotypes related to Shigellosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.9BTRC, CASP1, CRK, CTTN, IL10, LTA
2MP:00020067.9BTRC, CASP1, CD79A, IL10, LTF, SRC
3MP:00053847.1BTRC, CASP1, CD79A, CTTN, IL10, IRAK4
4MP:00053977.1BTRC, CASP1, CD79A, CTTN, IL10, IRAK4
5MP:00053877.0BTRC, CASP1, CD79A, CTTN, IL10, IRAK4
6MP:00053766.9BTRC, CASP1, CD79A, CRK, IL10, IRAK4

Drugs & Therapeutics for Shigellosis

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Drugs for Shigellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Rifaximinapproved, investigationalPhase 310180621-81-46436173
Synonyms:
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate
4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV
4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin
80621-81-4
88747-56-2
AC-19112
BRN 3584528
Bio-0556
C43H51N3O11
CHEMBL1617
D02554
DB01220
Fatroximin
Flonorm
L 105
L 105 (Ansamacrolide antibiotic)
L 105SV
LS-178059
LS-64147
Lormyx
Lumenax
MLS000759430
Normix
RedActiv
 
Rifacol
Rifamixin
Rifamycin L 105
Rifamycin L 105SV
Rifaxidin
Rifaximin
Rifaximin (USAN/INN)
Rifaximin [USAN:INN]
Rifaximina
Rifaximina [Spanish]
Rifaximine
Rifaximine [French]
Rifaximinum
Rifaximinum [Latin]
Rifaximinun
Rifaxin
Ritacol
S1790_Selleck
SMR000466324
Spiraxin
UNII-L36O5T016N
Xifaxan
Xifaxan, Rifacol, Fatroximin, Rifaximin
Xifaxsan
Xifaxsan (TN)
alpha-0817185
2
ZincapprovedPhase 322317440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
3Anti-Bacterial AgentsPhase 3, Phase 210884
4Nucleic Acid Synthesis InhibitorsPhase 34855
5RifamycinsPhase 397
6AntibodiesPhase 36045
7Gastrointestinal AgentsPhase 3, Phase 18109
8rifamycin SVPhase 397
9Anti-Infective AgentsPhase 3, Phase 221402
10ImmunoglobulinsPhase 36045
11MicronutrientsPhase 35802
12VaccinesPhase 3, Phase 2, Phase 16428
13Trace ElementsPhase 35802
14
Histamine PhosphateapprovedPhase 2103351-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
15
HistamineapprovedPhase 2103475614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
16
butyric acidexperimentalPhase 2363107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
17Antibiotics, AntitubercularPhase 26972
18Histamine AntagonistsPhase 2946
19Pharmaceutical SolutionsPhase 27793
20Neurotransmitter AgentsPhase 217734
21
Aluminum hydroxideapprovedPhase 120121645-51-2
Synonyms:
Al(OH)3
Aluminium hydroxide
Aluminium hydroxide gel, dried
 
Aluminium hydroxide, dried
Aluminum hydroxide gel, dried
Aluminum hydroxide, dried
Dried aluminium hydroxide
Dried aluminum hydroxide gel
22Anti-Ulcer AgentsPhase 11767
23AntacidsPhase 11767
24Adjuvants, ImmunologicPhase 12484
25Aluminum sulfatePhase 187
26
Formaldehydeapproved, vet_approved8450-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalin
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
27Disinfectants547
28Ether60

Interventional clinical trials:

(show all 35)
idNameStatusNCT IDPhase
1Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in IsraelCompletedNCT00368316Phase 3
2Zinc Supplementation in Shigella PatientsCompletedNCT00321126Phase 3
3Rifaximin for Prevention of Travellers' DiarrheaCompletedNCT00742469Phase 3
4Therapeutic Induction of Endogenous AntibioticsCompletedNCT00800930Phase 2
5Healthy Adult Volunteer Study for Two Doses of a Shigella VaccineCompletedNCT00210288Phase 2
6Shigella Flexneri 2a Invaplex 50 Vaccine Dose Finding and Assessment of ProtectionCompletedNCT00485134Phase 1, Phase 2
7Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine CandidateCompletedNCT01080716Phase 1, Phase 2
8A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan AdultsActive, not recruitingNCT02676895Phase 2
9Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2aActive, not recruitingNCT02646371Phase 2
10Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIbTerminatedNCT00866242Phase 2
11Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIaTerminatedNCT00866476Phase 2
12Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMPCompletedNCT01531530Phase 1
13Shigella Sonnel O-SPC/rBRU Conjugate VaccineCompletedNCT01369927Phase 1
14A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults.CompletedNCT02017899Phase 1
15Evaluate a New Shigella Sonnei Vaccine Administered Either by Intradermal, Intranasal or Intramuscular Route in Healthy AdultsCompletedNCT02034500Phase 1
16Safety Study of Inactivated Shigella Whole Cell Vaccine in AdultsCompletedNCT01509846Phase 1
17Safety and Reactogenicity of Bioconjugate Vaccine to Prevent ShigellaCompletedNCT01069471Phase 1
18Safety and Immunogenicity of Two Live, Attenuated Oral Shigella Sonnei Vaccines: WRSs2 and WRSs3CompletedNCT01336699Phase 1
19Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2aCompletedNCT02388009Phase 1
20Invaplex 50 Vaccine Dose-RangingCompletedNCT00082069Phase 1
21Effect of 15g Daily Consumption of NUTRIOSE on Healthy Volunteers Microbiota.CompletedNCT01897649Phase 1
22Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR) Administered Intranasally to Healthy, Adult VolunteersRecruitingNCT02445963Phase 1
23Phase 1 Study of dmLT ID Vaccination in Healthy AdultsRecruitingNCT02531685Phase 1
24Shigella Sonnei 53G ChallengeNot yet recruitingNCT02816346Phase 1
25Shigella WRSS1 Vaccine Trial in BangladeshNot yet recruitingNCT02934178Phase 1
26SF2a-TT15 Conjugate Vaccine in Healthy Adult VolunteersNot yet recruitingNCT02797236Phase 1
27Shigella Sonnei OSPC-rDT Conjugate VaccineWithdrawnNCT01399424Phase 1
28Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli InfectionsUnknown statusNCT01638039
29A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty HospitalsUnknown statusNCT01612572
30Experimental Phage Therapy of Bacterial InfectionsUnknown statusNCT00945087
31The Long Term Clinical Course of Postinfectious Irritable Bowel Syndrome After Shigellosis; A 10 Year Follow up StudyCompletedNCT02516683
32Safety Study of Live Shigella Vaccine in Bangladeshi Adults and ChildrenCompletedNCT01813071
33Evaluation of a Diagnostic Enteric Card for Management of DiarrheaCompletedNCT00736567
34Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive DisordersCompletedNCT02105714
35COmparison of MicroBiota AccordIng to Age in Crohn's Disease (COMeBACk)RecruitingNCT02839317

Search NIH Clinical Center for Shigellosis

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: dysentery, bacillary

Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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MalaCards organs/tissues related to Shigellosis:

36
Colon, T cells, Testes, Neutrophil, Appendix, Kidney, Brain

FMA organs/tissues related to Shigellosis:

17
Epithelium of colon

Publications for Shigellosis

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Articles related to Shigellosis:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Shigellosis in men who have sex with men: an overlooked opportunity to counsel with pre-exposure prophylaxis for HIV. (26945593)
2016
2
Shigellosis in Nepal: 13A years review of nationwide surveillance. (27814742)
2016
3
Molecular Characterization of Shigella sonnei: An Increasingly Prevalent Etiologic Agent of Shigellosis in Guizhou Province, Southwest of China. (27195892)
2016
4
Notes from the Field: Shigellosis Outbreak Among Men Who Have Sex with Men and Homeless Persons - Oregon, 2015-2016. (27513523)
2016
5
Development of a live attenuated bivalent oral vaccine against Shigella sonnei shigellosis and typhoid fever. (27803169)
2016
6
A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity. (26918643)
2016
7
Shigellosis. (27556171)
2016
8
Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection Against Shigellosis in a Controlled Human Challenge Study. (27927680)
2016
9
A review of the public health management of shigellosis in Australia in the era of culture-independent diagnostic testing. (27774718)
2016
10
Shigellosis: high rates of antibiotic resistance necessitate new treatment recommendations. (27078594)
2016
11
Shigellosis murine model established by intraperitoneal and intranasal route of administration: a comparative comprehension overview. (27664045)
2016
12
True Prevalence of Shigellosis in Indian Children with Acute Gastroenteritis: Have We Been Missing the Diagnosis? (27061990)
2016
13
Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome after Shigellosis: A 10-year Follow-up Study. (26908484)
2016
14
Shigellosis and Pregnancy in French Guiana: Obstetric and Neonatal Complications. (27114299)
2016
15
Shigellosis: Epidemiology in India. (27487999)
2016
16
Recent Outbreaks of Shigellosis in California Caused by Two Distinct Populations of Shigella sonnei with either Increased Virulence or Fluoroquinolone Resistance. (28028547)
2016
17
Shigellosis in refugees, Austria, July to November 2015. (26676065)
2015
18
Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study. (25936611)
2015
19
Shigella sonnei bacteraemia occurring in a young man with shigellosis. (25920737)
2015
20
Outbreak of Shigellosis in a Homeless Shelter With Healthcare Worker Transmission-British Columbia, April 2015. (26330023)
2015
21
Microbiota that affect risk for shigellosis in children in low-income countries. (25625766)
2015
22
Use of a culture-independent gastrointestinal multiplex PCR panel during a Shigellosis outbreak: considerations for clinical laboratories and public health. (25568430)
2015
23
Disparities of Shigellosis Rates among California Children by Race/Ethnicity and Census Tract Poverty Level, 2000-2010. (26020406)
2015
24
Shigellosis Outbreak in Al Batinah South Governorate, Oman: Case-control study. (26357558)
2015
25
Fulminant Shigellosis in a HIV Patient. (25821609)
2015
26
Shigella Infections in Household Contacts of Pediatric Shigellosis Patients in Rural Bangladesh. (26484778)
2015
27
Shigellosis in Subjects with Traveler's Diarrhea Versus Domestically Acquired Diarrhea: Implications for Antimicrobial Therapy and Human Immunodeficiency Virus Surveillance. (26195465)
2015
28
Intensified shigellosis epidemic associated with sexual transmission in men who have sex with men--Shigella flexneri and S. sonnei in England, 2004 to end of February 2015. (25953129)
2015
29
Invasive shigellosis in MSM. (26429891)
2015
30
Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. (24680068)
2014
31
Cholera and shigellosis: different epidemiology but similar responses to climate variability. (25229494)
2014
32
Shigellosis with decreased susceptibility to azithromycin. (25361413)
2014
33
Travel-related shigellosis in Quebec, Canada: an analysis of risk factors. (24889090)
2014
34
Shigellosis in Poland in 2012. (25135504)
2014
35
Virulence factors associated with pediatric shigellosis in Brazilian Amazon. (24877110)
2014
36
Investigation of key interventions for shigellosis outbreak control in China. (24736407)
2014
37
A large outbreak of shigellosis commencing in an internally displaced population, Papua New Guinea, 2013. (25648967)
2014
38
A mouse model of shigellosis by intraperitoneal infection. (23904297)
2014
39
Risk factors for diarrhea hospitalization in Bangladesh, 2000-2008: a case-case study of cholera and shigellosis. (25127553)
2014
40
Clinical and microbiological profiles of shigellosis in children. (25895190)
2014
41
Report: prevalence of shigellosis in three different areas of Karachi. (24577930)
2014
42
Recent trends in the epidemiology of shigellosis in Israel. (24559503)
2014
43
Use of population-based surveillance to define the high incidence of shigellosis in an urban slum in Nairobi, Kenya. (23505506)
2013
44
Gastrointestinal and extra-intestinal manifestations of childhood shigellosis in a region where all four species of Shigella are endemic. (23691156)
2013
45
50 Years ago in The Journal of Pediatrics: shigellosis in infancy and childhood: clinical and cerebrospinal fluid findings. (23617974)
2013
46
Housefly population density correlates with shigellosis among children in Mirzapur, Bangladesh: a time series analysis. (23818998)
2013
47
Infrequent cross-transmission of Shigella flexneri 2a strains among villages of a mountainous township in Taiwan with endemic shigellosis. (23899288)
2013
48
Dynamics of shigellosis epidemics: estimating individual-level transmission and reporting rates from national epidemiologic data sets. (24008913)
2013
49
Evaluation of underreporting of salmonellosis and shigellosis hospitalised cases in Greece, 2011: results of a capture-recapture study and a hospital registry review. (24060206)
2013
50
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. (23775017)
2013

Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Pathways related to Shigellosis according to KEGG:

34
id Name KEGG Source Accession
1Shigellosishsa05131

Pathways related to Shigellosis according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathwaysScoreTop Affiliating Genes
19.5BTRC, SRC
2
Show member pathways
9.5CDC42, SRC, VCL
39.5CDC42, SRC, VCL
49.5CRK, SRC, VCL
59.4CDC42, CTTN, SRC
69.4CDC42, CTTN, SRC
79.4CDC42, CTTN, SRC
89.4CXCL8, IRAK4, LTA
99.4CTTN, CXCL8, SRC
10
Show member pathways
9.4CDC42, CRK, SRC
119.4CDC42, CRK, SRC
129.4CDC42, CRK, SRC
139.3CRK, CXCL8, SRC
14
Show member pathways
9.3CDC42, PFN1, VCL
159.3CDC42, IRAK4, SRC
16
Show member pathways
9.3BTRC, CASP1, IRAK4
17
Show member pathways
9.1CDC42, CXCL8, LTF, SRC
18
Show member pathways
9.1CDC42, CRK, SRC, VCL
199.1CDC42, CRK, CTTN, SRC
209.1CXCL8, IL10, VCL
21
Show member pathways
9.1CXCL8, IL10, LTA
229.0CDC42, CTTN, PFN1, VCL
23
Show member pathways
9.0CASP1, CDC42, CXCL8, PFN1
24
Show member pathways
8.9CDC42, CRK, IRAK4, SRC
258.8CDC42, CRK, CTTN, SRC, VCL
26
Show member pathways
8.8CDC42, CTTN, PFN1, SRC
27
Show member pathways
8.7CD79A, CDC42, CRK, IL10
28
Show member pathways
8.7CASP1, CXCL8, IL10, SRC
298.6CASP1, CXCL8, IL10, IRAK4
30
Show member pathways
8.5CDC42, CRK, PFN1, SRC, VCL
31
Show member pathways
8.5CDC42, CRK, PFN1, SRC, VCL
32
Show member pathways
7.5CASP1, CDC42, CRK, CXCL8, IL10, LTA
337.3BTRC, CDC42, CRK, CTTN, CXCL8, PFN1
34
Show member pathways
7.1BTRC, CASP1, CD79A, CDC42, CRK, IRAK4

GO Terms for genes affiliated with Shigellosis

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Cellular components related to Shigellosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:00059139.7CTTN, PFN1, SRC, VCL
2cytoplasmGO:00057375.3BTRC, CD79A, CDC42, CRK, CTTN, IL10

Biological processes related to Shigellosis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell-cell adhesionGO:009013610.5CDC42, VCL
2branching involved in mammary gland duct morphogenesisGO:006044410.2BTRC, SRC
3ephrin receptor signaling pathwayGO:004801310.0CDC42, CRK, SRC
4negative regulation of growth of symbiont in hostGO:00441309.9IL10, LTA
5Fc-gamma receptor signaling pathway involved in phagocytosisGO:00380969.9CDC42, CRK, SRC
6response to molecule of bacterial originGO:00022379.8CXCL8, IL10
7cellular response to lipopolysaccharideGO:00712229.5CXCL8, IL10, SRC
8positive regulation of cytokine secretionGO:00507159.5CASP1, IL10, SRC
9vascular endothelial growth factor receptor signaling pathwayGO:00480109.4CDC42, CRK, SRC

Molecular functions related to Shigellosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cadherin binding involved in cell-cell adhesionGO:00986419.7CTTN, PFN1, SRC, VCL
2protein phosphorylated amino acid bindingGO:00453099.6BTRC, CRK
3protein bindingGO:00055154.5BTRC, CASP1, CD79A, CDC42, CRK, CTTN

Sources for Shigellosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet