MCID: SHG001
MIFTS: 65

Shigellosis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories

Summaries for Shigellosis

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CDC:4 Shigellosis is an infectious disease caused by a group of bacteria called Shigella. Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. Shigellosis usually resolves in 5 to 7 days. Some people who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others. The spread of Shigella can be stopped by frequent and careful handwashing with soap and taking other hygiene measures.

MalaCards based summary: Shigellosis, also known as shigella gastroenteritis, is related to arthritis and influenza. An important gene associated with Shigellosis is CASP1 (caspase 1, apoptosis-related cysteine peptidase), and among its related pathways are TRAF Pathway and Legionellosis. The drugs loperamide and loperamide hydrochloride and the compounds acetyl-tyr-val-ala-asp-cho and tlck have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and breast, and related mouse phenotypes are immune system and cardiovascular system.

Disease Ontology:10 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.

Wikipedia:65 Shigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is... more...

Aliases & Classifications for Shigellosis

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 45Novoseek, 49Orphanet, 4CDC, 62UMLS, 35MeSH, 57SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Shigellosis, Aliases & Descriptions:

Name: Shigellosis 10 43 12 45 49 4
Shigella Gastroenteritis 10 62
Shigella Flexneri Infectious Disease 10
Shigella Boydii Infectious Disease 10
 
Shigella Sonnei Infectious Disease 10
Dysentery, Bacillary 62
Bacillary Dysentery 10
Shigella Infections 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

49
shigellosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology10 DOID:12385
MeSH35 D004405
ICD9CM29 004.9, 004
Orphanet49 810
ICD10 via Orphanet28 A03.0, A03.1, A03.2 A03.3, A03.8, A03.9, more
UMLS via Orphanet63 C0013371

Related Diseases for Shigellosis

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Diseases related to Shigellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.3IL1R1, IL1B, CASP1, LTA, LTF
2influenza29.9CASP1, LTF, LTA
3colitis29.9LTF, IL1B, IL1R1
4blindness10.5
5cholera10.4
6paratyphoid fever10.4
7dysentery10.4
8gastroenteritis10.4
9diarrhea10.3
10irritable bowel syndrome10.3
11hemolytic-uremic syndrome10.2
12reactive arthritis10.2
13hepatitis10.2
14typhoid fever10.2
15bacteremia10.1
16appendicitis10.1
17measles10.1
18listeriosis10.1
19hepatitis a10.1
20acute diarrhea10.1
21campylobacteriosis10.1
22toxic encephalopathy10.1
23pneumonia10.1
24periodontitis10.1IL1B
25periodontal disease10.0LTF
26acute graft versus host disease10.0IL1R1, LTA
27juvenile rheumatoid arthritis10.0IL1R1, LTA
28myocardial infarction10.0VCL, CASP1
29toxic shock syndrome10.0IL1B, LTA
30acute respiratory distress syndrome10.0IL1B, LTA
31mastitis10.0LTF, IL1B
32gingivitis10.0IL1B, LTF
33otitis media10.0IL1B, LTF
34familial cold autoinflammatory syndrome10.0CASP1, IL1B, IL1R1
35cinca syndrome10.0CASP1, IL1B, IL1R1
36muckle-wells syndrome10.0IL1R1, IL1B, CASP1
37uveitis10.0LTA, IL1R1
38malaria10.0VCL, IL1B, IL1R1
39diabetes mellitus, insulin-dependent10.0LTA, IL1B, IL1R1
40bacterial vaginosis10.0LTF, IL1B, IL1R1
41chorioamnionitis10.0IL1R1, IL1B, LTF
42pancreatitis10.0LTF, IL1B, CASP1
43graft-versus-host disease, protection against10.0LTA, IL1R1
44systemic lupus erythematosus10.0IL1R1, LTA, LTF
45familial mediterranean fever, ar10.0IL1B, CARD17, CASP1
46multiple sclerosis, disease progression, modifier of10.0IL1R1, CASP1, LTA, IL1B
47monocytic leukemia10.0IL1B, LTF, CASP1, IL1R1
48gastric cancer, somatic10.0CASP1, IL1B, IL1R1, LTA
49cowpox10.0PFN3, CARD17, CASP1
50osteoarthritis10.0IL1R1, IL1B, LTA

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Symptoms for Shigellosis

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Drugs & Therapeutics for Shigellosis

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Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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MalaCards organs/tissues related to Shigellosis:

33
Colon, Breast, T cells, Brain, Kidney, Testes, Appendix, Neutrophil

FMA organs/tissues related to Shigellosis:

16
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

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MGI Mouse Phenotypes related to Shigellosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5LTF, LTA, RHOG, CASP1, IL1B, IL1R1
2MP:00053858.2LTA, CASP1, IL1B, IL1R1, VASP, VCL
3MP:00053978.0LTA, RHOG, CASP1, IL1B, IL1R1, VASP
4MP:00036318.0RHOG, CASP1, IL1B, IL1R1, VASP, LTA

Publications for Shigellosis

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Articles related to Shigellosis:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. (24680068)
2014
2
Investigation of key interventions for shigellosis outbreak control in China. (24736407)
2014
3
Use of population-based surveillance to define the high incidence of shigellosis in an urban slum in Nairobi, Kenya. (23505506)
2013
4
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. (23775017)
2013
5
Systemic shigellosis in South Africa. (22474223)
2012
6
Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases. (22606962)
2012
7
A 9-year study of shigellosis in Northeast Malaysia: Antimicrobial susceptibility and shifting species dominance. (21654922)
2011
8
Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia. (21029529)
2010
9
Risk factors for sporadic shigellosis, FoodNet 2005. (20113209)
2010
10
Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh. (17554249)
2008
11
Comparison of cost-of-illness with willingness-to-pay estimates to avoid shigellosis: evidence from China. (18234703)
2008
12
Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the Peruvian Amazon. (18710884)
2008
13
High prevalence of CTX-M-15 extended-spectrum beta-lactamase among contacts of patients with shigellosis due to Shigella flexneri carrying CTX-M-15. (17646198)
2007
14
Risk factors for shigellosis in Thailand. (16997593)
2006
15
Azithromycin as an alternative to nalidixic acid in the therapy of childhood shigellosis. (15071299)
2004
16
Acceptability and accessibility of a Shigellosis vaccine in Nha Trang city of Viet Nam. (15473518)
2004
17
Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development. (15030306)
2003
18
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase. (11178905)
2001
19
Disease-dependent changes in T-cell populations in patients with shigellosis. (10843411)
2000
20
Pathogenesis of shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation and vaccine development. (10211438)
1998
21
Double-blind, randomized clinical trial for safety and efficacy of norfloxacin for shigellosis in children. (9099325)
1997
22
Pathogenesis and immune responses in shigellosis. (8993387)
1996
23
Prevalence of shigellosis in the U.S.: consistency with dose-response information. (8856376)
1996
24
Shigellosis: from molecular pathogenesis of infection to protective immunity and vaccine development. (9127893)
1996
25
Shigellosis in Thai children: experience from a rural hospital 1985-1993. (8629073)
1995
26
Epidemiological, clinical and microbiological features of shigellosis among hospitalized children in northern Israel. (7660077)
1995
27
Short-term pefloxacin therapy in Madagascan children with shigellosis due to multiresistant organisms. (7888566)
1994
28
Moose soup shigellosis in Alaska. (8048226)
1994
29
An outbreak of shigellosis in a slum colony of Delhi-1990. (8014439)
1993
30
Evaluation of an intervention program for the control of an outbreak of shigellosis among institutionalized persons. (8228351)
1993
31
Shigellosis complicated by perforated appendix. (8483634)
1993
32
Shigellosis in Thai children: epidemiologic, clinical and laboratory features. (1565537)
1992
33
From the Centers for Disease Control. Shigellosis in child day care centers--Lexington-Fayette County, Kentucky, 1991. (1640601)
1992
34
Shigellosis-associated encephalopathy. (1408493)
1992
35
Efficacy of norfloxacin for shigellosis: a double-blind randomised clinical trial. (1430968)
1992
36
Evaluation of indigenous plants in the treatment of acute shigellosis. (1816661)
1991
37
Potentials of Shigella flexneri Y strain TSF21 as a candidate vaccine against shigellosis: safety, immunogenicity and protective efficacy in Bonnet monkeys. (1878259)
1991
38
An outbreak of shigellosis aboard a cruise ship caused by a multiple-antibiotic-resistant strain of Shigella flexneri. (1652203)
1991
39
Shigellosis. (1861289)
1991
40
The use of hygiene, cohorting, and antimicrobial therapy to control an outbreak of shigellosis. (2405639)
1990
41
Single-dose ciprofloxacin for shigellosis. (1971401)
1990
42
Death in shigellosis: incidence and risk factors in hospitalized patients. (2313128)
1990
43
Recurrent shigellosis complicating human immunodeficiency virus infection: failure of pre-existing antibodies to confer protection. (2642653)
1989
44
Plasmid profile as a useful marker of a Shigella dysenteriae type 1 strain causing an epidemic of shigellosis. (3077946)
1988
45
A shigellosis outbreak traced to commercially distributed shredded lettuce. (3057879)
1988
46
Leads from the MMWR. Multiply resistant shigellosis in a day-care center--Texas. (3540326)
1987
47
Shigellosis in children. (3428993)
1987
48
Comparative efficacies of single intravenous doses of ceftriaxone and ampicillin for shigellosis in a placebo-controlled trial. (3518625)
1986
49
The relation between production of cytotoxin and clinical features in shigellosis. (3519788)
1986
50
Incidence of shigellosis among paediatric diarrhoeal disorders (a bacteriological study). (6491334)
1984

Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Pathways related to Shigellosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9LTA, CASP1
29.8CASP1, IL1B
39.8CASP1, IL1B
49.8IL1B, LTA
5
Show member pathways
IL27-mediated signaling events38
9.8IL1B, LTA
6
Show member pathways
Serotonin Transporter Activity38
9.8IL1R1, IL1B
79.7VASP, VCL
8
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.6LTA, CASP1, IL1R1
9
Show member pathways
9.6VCL, CASP1, LTA
10
Show member pathways
9.6IL1B, CASP1, LTA
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.5CASP1, IL1B, IL1R1
12
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.5IL1R1, CASP1, IL1B
13
Show member pathways
MAPK signaling pathway38
9.5IL1R1, IL1B, CASP1
14
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5LTA, IL1B, IL1R1
15
Show member pathways
9.5LTA, IL1B, IL1R1
16
Show member pathways
9.5IL1B, LTA, IL1R1
179.5IL1R1, IL1B, LTA
189.5VCL, IL1B, IL1R1
19
Show member pathways
9.3LTA, IL1R1, CASP1, IL1B
20
Show member pathways
9.3CASP1, LTA, IL1R1, IL1B
219.2VCL, RHOG, ARPC5L
22
Show member pathways
9.0IL1B, CASP1, CARD17
23
Show member pathways
8.9LTA, IL1B, VCL, CASP1, IL1R1
24
Show member pathways
8.9PFN4, VASP, PFN3
25
Show member pathways
8.7IL1R1, IL1B, CARD17, CASP1
26
Show member pathways
8.7IL1B, CARD17, CASP1, IL1R1
27
Show member pathways
8.5PFN4, VCL, ARPC5L, PFN3
28
Show member pathways
7.4PFN4, PFN3, VCL, IL1B, CASP1, RHOG

Compounds for genes affiliated with Shigellosis

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Compounds related to Shigellosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1acetyl-tyr-val-ala-asp-cho4510.2IL1B, CASP1
2tlck4510.1CASP1, IL1B
3ag-1264510.1CASP1, IL1B
4muramyl dipeptide45 3011.1CASP1, IL1B
5monosodium urate4510.1IL1R1, IL1B
6toxin-14510.0LTA, IL1B
7cytochalasin4510.0VCL, LTF
8rabeprazole45 51 26 1313.0IL1B, LTF
9git 276110.0IL1R1, IL1B
10anakinra45 1311.0IL1R1, CASP1, IL1B
11as 10145 6111.0IL1R1, CASP1, IL1B
12cuprophan4510.0IL1R1, CASP1, IL1B
134-ipp6110.0IL1R1, IL1B
14lipoteichoic acid459.9IL1R1, IL1B, LTA
15diphenyleneiodonium459.9IL1R1, IL1B, CASP1
16etanercept45 51 1311.9IL1R1, IL1B, LTA
17minocycline45 1310.9LTF, IL1B, CASP1
18gold sodium thiomalate459.9IL1B, IL1R1
19peptidoglycan45 3010.9CASP1, IL1R1, IL1B
20il 10459.9IL1R1, LTA, IL1B
21tenidap45 3010.9IL1B, LTF, IL1R1
22infliximab45 51 1311.9IL1R1, IL1B, LTA
23ivig459.9LTA, IL1B, IL1R1
24ibuprofen45 30 51 26 1313.8LTF, IL1R1, IL1B
25leukotriene b445 61 2611.8IL1R1, IL1B, LTF
26hydrocortisone45 3 61 1312.7IL1B, IL1R1, LTF
27neopterin459.6LTF, LTA, IL1B, IL1R1
28cyclosporin a45 30 6111.6IL1R1, LTF, LTA, CASP1
29mannose459.6LTF, LTA, VCL
30hyaluronic acid45 2610.6IL1B, LTA, LTF, IL1R1
31n acetylcysteine459.6IL1B, IL1R1, CASP1, LTF
32phosphatidylserine45 30 1311.5VCL, CASP1, LTF
33pirfenidone45 6110.5IL1R1, IL1B
34aspirin45 51 30 2612.5VASP, IL1R1, IL1B, CASP1
35fmlp459.5IL1B, LTA, LTF
36fibrinogen459.4VASP, IL1R1, LTF, VCL
37pentoxifylline45 1310.4CASP1, IL1R1, IL1B, LTA, LTF
38endotoxin459.4LTA, IL1B, CASP1, IL1R1, LTF
39h2o2459.4IL1R1, LTF, LTA, VCL, CASP1
40actinomycin d459.3LTF, LTA, CASP1, IL1B, IL1R1
41cycloheximide459.3IL1R1, IL1B, CASP1, LTA, VCL
42pge2459.3IL1R1, IL1B, CASP1, LTA, LTF
43dexamethasone45 51 30 1312.3LTF, LTA, CASP1, IL1B, IL1R1
44retinoic acid45 2610.2LTA, CASP1, IL1B, LTF, IL1R1
45prostacyclin459.2LTF, IL1B, VASP
46threonine459.2VASP, CASP1, LTA, VCL, IL1R1
47indomethacin45 30 61 1312.2LTF, LTA, IL1B, IL1R1, VASP
48vegf459.0LTA, CASP1, LTF, IL1B, IL1R1, VCL
49nitric oxide45 26 1310.9IL1B, CASP1, VCL, VASP, IL1R1, LTA
50serine458.8VCL, LTA, LTF, CASP1, IL1R1, VASP

GO Terms for genes affiliated with Shigellosis

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Cellular components related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.6LTF, VCL, IL1R1, IL1B, CASP1
2extracellular vesicular exosomeGO:00700628.4ARPC5L, LTF, RHOG, VASP, VCL
3cytoskeletonGO:00058568.4PFN4, PFN3, VCL, ARPC5L

Biological processes related to Shigellosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:003261110.0CASP1, IL1B
2regulation of inflammatory responseGO:00507279.9CASP1, IL1R1
3response to ATPGO:00331989.9CASP1, IL1B
4cellular response to organic substanceGO:00713109.7CASP1, IL1B
5positive regulation of interferon-gamma productionGO:00327299.5LTA, IL1B
6positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.5IL1B, CASP1, LTF
7actin cytoskeleton organizationGO:00300369.0RHOG, PFN4, PFN3

Molecular functions related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:00037798.0ARPC5L, VASP, VCL, PFN4, PFN3

Products for genes affiliated with Shigellosis

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Sources for Shigellosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet