MCID: SHG001
MIFTS: 57

Shigellosis malady

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Shigellosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 2CDC, 36MeSH, 65UMLS, 27ICD10, 29ICD9CM, 59SNOMED-CT, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Shigellosis:

Name: Shigellosis 10 45 47 12 51 2
Dysentery, Bacillary 36 65
Shigella Flexneri Infectious Disease 10
Shigella Sonnei Infectious Disease 10
 
Shigella Boydii Infectious Disease 10
Shigella Gastroenteritis 10
Bacillary Dysentery 10
Shigella Infections 65

Characteristics:

Orphanet epidemiological data:

51
shigellosis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Disease Ontology10 DOID:12385
MeSH36 D004405
Orphanet51 810
ICD10 via Orphanet28 A03.0, A03.1, A03.2 A03.3, A03.8, A03.9, more
UMLS via Orphanet66 C0013371
UMLS65 C0013371, C0302358, C0302359 C0302360, C0302361, C1527298, more

Summaries for Shigellosis

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Disease Ontology:10 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in Shigella boydii, has material basis in Shigella dysenteriae, has material basis in Shigella flexneri, or has material basis in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted by ingestion of food and water contaminated with feces.

MalaCards based summary: Shigellosis, also known as dysentery, bacillary, is related to superficial mycosis and plantar nerve lesion. An important gene associated with Shigellosis is VCL (Vinculin), and among its related pathways are Atypical NF-kappaB pathway and Adherens junction. The drugs loperamide and loperamide hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and prostate, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:68 Shigellosis, also known as bacillary dysentery or Marlow syndrome, in its most severe manifestation, is... more...

Related Diseases for Shigellosis

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Diseases related to Shigellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1superficial mycosis10.4CXCL8, LTF
2plantar nerve lesion10.4CXCL8, IL1B
3corneal abscess10.4CXCL8, IL1B
4chemical colitis10.3CDC42, LTF
5primary lacrimal atrophy10.3CXCL8, IL1B
6neonatal period electroclinical syndrome10.3CXCL8, IL1B
7neutropenia, severe congenital, x-linked10.3CDC42, CTTN, SRC
8ovarian dysgenesis 210.3BTRC, CDC42
9testicular granulosa cell tumor10.2CXCL8, IL1B
10viral gastritis10.2CXCL8, IL1B, VCL
11cholera10.1
12dysentery10.1
13far eastern spotted fever10.1CASP1, CXCL8
14wells-jankovic syndrome10.1CXCL8, IL1B
15eyelid neoplasm10.1CXCL8, IL1B
16diarrhea10.1
17encephalopathy10.1
18rhabdoid cancer10.0IL1B, LTF
19liver leiomyosarcoma10.0CXCL8, IL1B, NOD1
20peripheral retinal degeneration10.0CXCL8, IL1B, LTF
21alcoholic gastritis10.0CXCL8, IL1B, LTF
22periodontal disease10.0CXCL8, IL1B, LTF
23granulomatous orchitis10.0CXCL8, IL1B, LTF
24foveal hypoplasia 110.0CXCL8, IL1B, LTF
25hemolytic-uremic syndrome10.0
26rectum signet ring adenocarcinoma10.0CXCL8, IL1B, LTF
27optic neuritis10.0CXCL8, IL1B
28mononeuritis of lower limb9.9CXCL8, IL1B, IRAK4
29hepatitis9.9
30typhoid fever9.9
31urea cycle disorder9.9CXCL8, IL1B, LTF
32chudley rozdilsky syndrome9.9CASP1, IL1B
33tinea capitis9.8CASP1, IL1B
34familial cold-induced inflammatory syndrome 19.8CASP1, IL1B
35bacteremia9.8
36acute diarrhea9.8
37listeriosis9.8
38hepatitis a9.8
39campylobacteriosis9.8
40toxic encephalopathy9.8
41pneumonia9.8
42appendicitis9.8
43measles9.8
44ischemic colitis9.8CXCL8, IL1B, LTF
45cutaneous leishmaniasis9.8IL1B, LTF, NOD1
46submandibular gland disease9.8IL1B, IRAK4, LTF
47glioblastoma multiforme9.8CASP1, IL1B
48insulin-like growth factor i9.7
49osmotic diarrhea9.7
50brugada syndrome9.7

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Symptoms for Shigellosis

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Drugs & Therapeutics for Shigellosis

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Drugs for Shigellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ZincapprovedPhase 314777440-66-623994, 32051
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
2
Rifaximinapproved, investigationalPhase 39480621-81-46436173
Synonyms:
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate
4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV
4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin
80621-81-4
88747-56-2
AC-19112
BRN 3584528
Bio-0556
C43H51N3O11
CHEMBL1617
D02554
DB01220
Fatroximin
Flonorm
L 105
L 105 (Ansamacrolide antibiotic)
L 105SV
LS-178059
LS-64147
Lormyx
Lumenax
MLS000759430
Normix
RedActiv
Rifacol
 
Rifamixin
Rifamycin L 105
Rifamycin L 105SV
Rifaxidin
Rifaximin
Rifaximin (USAN/INN)
Rifaximin [USAN:INN]
Rifaximina
Rifaximina [Spanish]
Rifaximine
Rifaximine [French]
Rifaximinum
Rifaximinum [Latin]
Rifaximinun
Rifaxin
Ritacol
S1790_Selleck
SMR000466324
Spiraxin
UNII-L36O5T016N
Xifaxan
Xifaxan, Rifacol, Fatroximin, Rifaximin
Xifaxsan
Xifaxsan (TN)
Zaxine
alpha-0817185
3Nucleic Acid Synthesis InhibitorsPhase 33836
4AntibodiesPhase 34477
5Immunologic FactorsPhase 3, Phase 1, Phase 218483
6Anti-Infective AgentsPhase 3, Phase 217220
7Gastrointestinal AgentsPhase 36401
8VaccinesPhase 3, Phase 2, Phase 16085
9ImmunoglobulinsPhase 34477
10MicronutrientsPhase 33901
11Trace ElementsPhase 33900
12
Histamine PhosphateapprovedPhase 290651-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
EINECS 200-118-4
 
H0147
Histamine Positive Skin Test Control
Histamine Positive skin test control
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
13
butyric acidexperimentalPhase 2292107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
14Neurotransmitter AgentsPhase 214795
15Pharmaceutical SolutionsPhase 27004
16Anti-Bacterial AgentsPhase 29140
17Histamine AntagonistsPhase 2826
18Antibiotics, AntitubercularPhase 25971
19
histaminePhase 290675614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
20
Aluminum hydroxideapprovedPhase 1178
Synonyms:
Al(OH)3
Aluminiumhydroxid
 
Aluminum Hydroxide
Aluminum hydroxide
Dermadrox
21
Formaldehydeexperimental7350-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
22Ether52

Interventional clinical trials:

(show all 31)
idNameStatusNCT IDPhase
1Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in IsraelCompletedNCT00368316Phase 3
2Zinc Supplementation in Shigella PatientsCompletedNCT00321126Phase 3
3Rifaximin for Prevention of Travellers' DiarrheaCompletedNCT00742469Phase 3
4Therapeutic Induction of Endogenous AntibioticsCompletedNCT00800930Phase 2
5Healthy Adult Volunteer Study for Two Doses of a Shigella VaccineCompletedNCT00210288Phase 2
6Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine CandidateCompletedNCT01080716Phase 1, Phase 2
7Shigella Flexneri 2a Invaplex 50 Vaccine Dose Finding and Assessment of ProtectionCompletedNCT00485134Phase 1, Phase 2
8Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2aRecruitingNCT02646371Phase 2
9A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan AdultsNot yet recruitingNCT02676895Phase 2
10Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIbTerminatedNCT00866242Phase 2
11Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIaTerminatedNCT00866476Phase 2
12Shigella Sonnel O-SPC/rBRU Conjugate VaccineCompletedNCT01369927Phase 1
13Safety Study of Inactivated Shigella Whole Cell Vaccine in AdultsCompletedNCT01509846Phase 1
14Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMPCompletedNCT01531530Phase 1
15Safety and Immunogenicity of Two Live, Attenuated Oral Shigella Sonnei Vaccines: WRSs2 and WRSs3CompletedNCT01336699Phase 1
16A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults.CompletedNCT02017899Phase 1
17Evaluate a New Shigella Sonnei Vaccine Administered Either by Intradermal, Intranasal or Intramuscular Route in Healthy AdultsCompletedNCT02034500Phase 1
18Safety and Reactogenicity of Bioconjugate Vaccine to Prevent ShigellaCompletedNCT01069471Phase 1
19Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2aCompletedNCT02388009Phase 1
20Invaplex 50 Vaccine Dose-RangingCompletedNCT00082069Phase 1
21Effect of 15g Daily Consumption of NUTRIOSE on Healthy Volunteers Microbiota.CompletedNCT01897649Phase 1
22Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR) Administered Intranasally to Healthy, Adult VolunteersRecruitingNCT02445963Phase 1
23Phase 1 Study of dmLT ID Vaccination in Healthy AdultsNot yet recruitingNCT02531685Phase 1
24Shigella Sonnei OSPC-rDT Conjugate VaccineWithdrawnNCT01399424Phase 1
25The Long Term Clinical Course of Postinfectious Irritable Bowel Syndrome After Shigellosis; A 10 Year Follow up StudyCompletedNCT02516683
26Safety Study of Live Shigella Vaccine in Bangladeshi Adults and ChildrenCompletedNCT01813071
27Evaluation of a Diagnostic Enteric Card for Management of DiarrheaCompletedNCT00736567
28Experimental Phage Therapy of Bacterial InfectionsRecruitingNCT00945087
29A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty HospitalsActive, not recruitingNCT01612572
30Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive DisordersActive, not recruitingNCT02105714
31Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli InfectionsNot yet recruitingNCT01638039

Search NIH Clinical Center for Shigellosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: dysentery, bacillary

Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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MalaCards organs/tissues related to Shigellosis:

33
Colon, Prostate, B cells, Breast, T cells, Kidney, Heart

FMA organs/tissues related to Shigellosis:

16
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

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MGI Mouse Phenotypes related to Shigellosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053976.3BTRC, CASP1, CTTN, IL1B, IRAK4, LTF
2MP:00053876.0BTRC, CASP1, CTTN, IL1B, IRAK4, LTF

Publications for Shigellosis

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Articles related to Shigellosis:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Shigellosis in men who have sex with men: an overlooked opportunity to counsel with pre-exposure prophylaxis for HIV. (26945593)
2016
2
Disparities of Shigellosis Rates among California Children by Race/Ethnicity and Census Tract Poverty Level, 2000-2010. (26020406)
2015
3
Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. (24680068)
2014
4
Use of population-based surveillance to define the high incidence of shigellosis in an urban slum in Nairobi, Kenya. (23505506)
2013
5
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. (23775017)
2013
6
Systemic shigellosis in South Africa. (22474223)
2012
7
Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases. (22606962)
2012
8
A 9-year study of shigellosis in Northeast Malaysia: Antimicrobial susceptibility and shifting species dominance. (21654922)
2011
9
Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia. (21029529)
2010
10
Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh. (17554249)
2008
11
Comparison of cost-of-illness with willingness-to-pay estimates to avoid shigellosis: evidence from China. (18234703)
2008
12
Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the Peruvian Amazon. (18710884)
2008
13
High prevalence of CTX-M-15 extended-spectrum beta-lactamase among contacts of patients with shigellosis due to Shigella flexneri carrying CTX-M-15. (17646198)
2007
14
Risk factors for shigellosis in Thailand. (16997593)
2006
15
Azithromycin as an alternative to nalidixic acid in the therapy of childhood shigellosis. (15071299)
2004
16
Acceptability and accessibility of a Shigellosis vaccine in Nha Trang city of Viet Nam. (15473518)
2004
17
Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development. (15030306)
2003
18
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase. (11178905)
2001
19
Disease-dependent changes in T-cell populations in patients with shigellosis. (10843411)
2000
20
Pathogenesis of shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation and vaccine development. (10211438)
1998
21
Double-blind, randomized clinical trial for safety and efficacy of norfloxacin for shigellosis in children. (9099325)
1997
22
Pathogenesis and immune responses in shigellosis. (8993387)
1996
23
Prevalence of shigellosis in the U.S.: consistency with dose-response information. (8856376)
1996
24
Shigellosis: from molecular pathogenesis of infection to protective immunity and vaccine development. (9127893)
1996
25
Shigellosis in Thai children: experience from a rural hospital 1985-1993. (8629073)
1995
26
Epidemiological, clinical and microbiological features of shigellosis among hospitalized children in northern Israel. (7660077)
1995
27
Short-term pefloxacin therapy in Madagascan children with shigellosis due to multiresistant organisms. (7888566)
1994
28
Moose soup shigellosis in Alaska. (8048226)
1994
29
An outbreak of shigellosis in a slum colony of Delhi-1990. (8014439)
1993
30
Evaluation of an intervention program for the control of an outbreak of shigellosis among institutionalized persons. (8228351)
1993
31
Shigellosis complicated by perforated appendix. (8483634)
1993
32
Shigellosis in Thai children: epidemiologic, clinical and laboratory features. (1565537)
1992
33
From the Centers for Disease Control. Shigellosis in child day care centers--Lexington-Fayette County, Kentucky, 1991. (1640601)
1992
34
Shigellosis-associated encephalopathy. (1408493)
1992
35
Efficacy of norfloxacin for shigellosis: a double-blind randomised clinical trial. (1430968)
1992
36
Evaluation of indigenous plants in the treatment of acute shigellosis. (1816661)
1991
37
Potentials of Shigella flexneri Y strain TSF21 as a candidate vaccine against shigellosis: safety, immunogenicity and protective efficacy in Bonnet monkeys. (1878259)
1991
38
An outbreak of shigellosis aboard a cruise ship caused by a multiple-antibiotic-resistant strain of Shigella flexneri. (1652203)
1991
39
Shigellosis. (1861289)
1991
40
The use of hygiene, cohorting, and antimicrobial therapy to control an outbreak of shigellosis. (2405639)
1990
41
Single-dose ciprofloxacin for shigellosis. (1971401)
1990
42
Death in shigellosis: incidence and risk factors in hospitalized patients. (2313128)
1990
43
Recurrent shigellosis complicating human immunodeficiency virus infection: failure of pre-existing antibodies to confer protection. (2642653)
1989
44
Plasmid profile as a useful marker of a Shigella dysenteriae type 1 strain causing an epidemic of shigellosis. (3077946)
1988
45
A shigellosis outbreak traced to commercially distributed shredded lettuce. (3057879)
1988
46
Leads from the MMWR. Multiply resistant shigellosis in a day-care center--Texas. (3540326)
1987
47
Shigellosis in children. (3428993)
1987
48
Comparative efficacies of single intravenous doses of ceftriaxone and ampicillin for shigellosis in a placebo-controlled trial. (3518625)
1986
49
The relation between production of cytotoxin and clinical features in shigellosis. (3519788)
1986
50
Incidence of shigellosis among paediatric diarrhoeal disorders (a bacteriological study). (6491334)
1984

Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Pathways related to Shigellosis according to KEGG:

31
id Name KEGG Source Accession
1Shigellosishsa05131

Pathways related to Shigellosis according to GeneCards Suite gene sharing:

(show all 42)
idSuper pathwaysScoreTop Affiliating Genes
19.6BTRC, SRC
29.6CDC42, SRC, VCL
3
Show member pathways
9.6CDC42, SRC, VCL
49.6CDC42, CTTN, SRC
59.6CDC42, CTTN, SRC
69.6CDC42, CTTN, SRC
79.5CRK, SRC, VCL
89.5CTTN, CXCL8, SRC
99.5CDC42, CRK, SRC
109.5CDC42, CRK, SRC
11
Show member pathways
9.5CDC42, CRK, SRC
129.5CRK, CXCL8, SRC
139.5CDC42, IRAK4, SRC
149.4CXCL8, IL1B, VCL
159.4CDC42, CXCL8, IL1B
169.4CDC42, CXCL8, IL1B
17
Show member pathways
9.3CDC42, CTTN, SRC, VCL
189.3CXCL8, IL1B, IRAK4
199.3CXCL8, IL1B, SRC
20
Show member pathways
9.3CDC42, CRK, SRC, VCL
219.3CDC42, CRK, SRC, VCL
229.2CDC42, CRK, CTTN, SRC
23
Show member pathways
9.2CDC42, CRK, CXCL8, SRC
24
Show member pathways
9.1CDC42, CTTN, PFN1, SRC
259.1CASP1, IL1B
269.1CASP1, IL1B
279.0CDC42, CRK, CTTN, SRC, VCL
28
Show member pathways
8.8CDC42, CRK, PFN1, SRC, VCL
29
Show member pathways
8.8CDC42, CRK, PFN1, SRC, VCL
30
Show member pathways
8.8CDC42, CRK, PFN1, SRC, VCL
318.8CASP1, CXCL8, IL1B
32
Show member pathways
8.8CASP1, IL1B, SRC
33
Show member pathways
8.6CDC42, CXCL8, LTF, NOD1, SRC
34
Show member pathways
8.4CASP1, IL1B, IRAK4, SRC
35
Show member pathways
8.2CASP1, CXCL8, IL1B, NOD1
36
Show member pathways
8.1CASP1, CDC42, CXCL8, IL1B, PFN1
377.9CASP1, CXCL8, IL1B, IRAK4, NOD1
38
Show member pathways
7.6BTRC, CASP1, IL1B, IRAK4, NOD1
39
Show member pathways
7.6CASP1, CDC42, CRK, CXCL8, IL1B, SRC
40
Show member pathways
7.5CASP1, CXCL8, IL1B, IRAK4, NOD1, SRC
417.1BTRC, CDC42, CRK, CTTN, CXCL8, NOD1
42
Show member pathways
6.2BTRC, CASP1, CDC42, CRK, IL1B, IRAK4

GO Terms for genes affiliated with Shigellosis

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Biological processes related to Shigellosis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase activityGO:004355210.2CDC42, SRC
2negative regulation of extrinsic apoptotic signaling pathwayGO:200123710.2CTTN, SRC
3cellular response to fatty acidGO:007139810.1IL1B, SRC
4positive regulation of neutrophil chemotaxisGO:009002310.1CXCL8, IL1B
5regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.0BTRC, IL1B
6positive regulation of cytokine secretionGO:00507159.9CASP1, SRC
7protein destabilizationGO:00316489.9BTRC, SRC
8positive regulation of stress-activated MAPK cascadeGO:00328749.9IL1B, NOD1
9Fc-gamma receptor signaling pathway involved in phagocytosisGO:00380969.9CDC42, CRK, SRC
10interleukin-1 beta productionGO:00326119.8CASP1, IL1B
11response to ATPGO:00331989.8CASP1, IL1B
12stimulatory C-type lectin receptor signaling pathwayGO:00022239.5BTRC, IL1B, SRC
13nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayGO:00358729.5CASP1, NOD1
14positive regulation of NF-kappaB transcription factor activityGO:00510929.4IL1B, LTF, NOD1
15intracellular signal transductionGO:00355569.4CXCL8, IRAK4, NOD1, SRC
16cellular response to lipopolysaccharideGO:00712229.3CXCL8, IL1B, SRC
17positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.1CASP1, IRAK4, NOD1
18toll-like receptor 9 signaling pathwayGO:00341628.9BTRC, IRAK4, NOD1
19signal transductionGO:00071657.5BTRC, CASP1, CXCL8, NOD1, SRC
20innate immune responseGO:00450877.2BTRC, CASP1, CDC42, CRK, IRAK4, NOD1

Sources for Shigellosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet