MCID: SHG001
MIFTS: 52

Shigellosis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories

Aliases & Classifications for Shigellosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 2CDC, 65UMLS, 36MeSH, 59SNOMED-CT, 29ICD9CM, 28ICD10 via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Shigellosis:

Name: Shigellosis 10 45 47 12 51 2
Dysentery, Bacillary 65 36
Shigella Flexneri Infectious Disease 10
Shigella Boydii Infectious Disease 10
 
Shigella Sonnei Infectious Disease 10
Shigella Gastroenteritis 10
Bacillary Dysentery 10
Shigella Infections 65


Classifications:



Characteristics (Orphanet epidemiological data):

51
shigellosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology10 DOID:12385
ICD9CM29 004, 004.9
MeSH36 D004405
Orphanet51 810
ICD10 via Orphanet28 A03.0, A03.1, A03.2 A03.3, A03.8, A03.9, more
UMLS via Orphanet66 C0013371

Summaries for Shigellosis

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Disease Ontology:10 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.

MalaCards based summary: Shigellosis, also known as dysentery, bacillary, is related to acute diarrhea and cholera. An important gene associated with Shigellosis is CASP1 (Caspase 1, Apoptosis-Related Cysteine Peptidase), and among its related pathways are Syndecan-3-mediated signaling events and Adherens junction. The drugs loperamide and bismuth subcarbonate have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and t cells, and related mouse phenotypes are limbs/digits/tail and nervous system.

Wikipedia:68 Shigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is... more...

Related Diseases for Shigellosis

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Diseases related to Shigellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1acute diarrhea30.5CXCL8, LTF
2cholera10.4
3dysentery10.4
4paratyphoid fever10.4
5diarrhea10.4
6encephalopathy10.4
7hemolytic-uremic syndrome10.3
8arthritis10.2
9reactive arthritis10.2
10hepatitis10.2
11typhoid fever10.2
12bone giant cell sarcoma10.2CASP1, CXCL8
13seizures - intellectual disability due to hydroxylysinuria10.2CASP1, SRC
14subependymal glioma10.2CDC42, IL10
15papilledema10.2CXCL8, LTF
16pharyngitis10.2CXCL8, IL10
17wild type abeta2m amyloidosis10.2CXCL8, IL10
18rhizomelic chondrodysplasia punctata10.1CXCL8, IL10
19cicatricial entropion10.1CXCL8, LTF
20malignant sertoli-leydig cell tumor of ovary10.1CXCL8, LTA
21bacteremia10.1
22toxic encephalopathy10.1
23campylobacteriosis10.1
24listeriosis10.1
25hepatitis a10.1
26appendicitis10.1
27measles10.1
28pneumonia10.1
29chorioamnionitis10.1CXCL8, IL10
30early-onset non-syndromic cataract10.1IL10, LTF
31gastroschisis10.1CXCL8, LTF
32mammary paget's disease10.1CD79A, CXCL8
33hair defect with photosensitivity and mental retardation10.0CXCL8, LTF
34uvula cancer10.0CD79A, TTR
35bagassosis10.0CD79A, CXCL8
36neurotic excoriation10.0IL10, LTA
37fibroosseous pseudotumor of digits10.0CD79A, LTF
38wegener granulomatosis10.0CXCL8, IL10, LTF
39mental depression10.0CXCL8, IL10, IRAK4
40peroneal nerve paralysis10.0CD79A, LTF
41subclavian artery aneurysm10.0CD79A, TTR
42insulin-like growth factor i10.0
43brugada syndrome10.0
44marasmus10.0
45q fever10.0
46henoch-schoenlein purpura10.0
47chagas disease10.0
48cryptosporidiosis10.0
49toxic megacolon10.0
50ancylostomiasis10.0

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Symptoms for Shigellosis

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Drugs & Therapeutics for Shigellosis

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Drugs for Shigellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ZincapprovedPhase 314047440-66-623994, 32051
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
2
Rifaximinapproved, investigationalPhase 39080621-81-46436173
Synonyms:
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate
4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV
4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin
80621-81-4
88747-56-2
AC-19112
BRN 3584528
Bio-0556
C43H51N3O11
CHEMBL1617
D02554
DB01220
Fatroximin
Flonorm
L 105
L 105 (Ansamacrolide antibiotic)
L 105SV
LS-178059
LS-64147
Lormyx
Lumenax
MLS000759430
Normix
RedActiv
Rifacol
 
Rifamixin
Rifamycin L 105
Rifamycin L 105SV
Rifaxidin
Rifaximin
Rifaximin (USAN/INN)
Rifaximin [USAN:INN]
Rifaximina
Rifaximina [Spanish]
Rifaximine
Rifaximine [French]
Rifaximinum
Rifaximinum [Latin]
Rifaximinun
Rifaxin
Ritacol
S1790_Selleck
SMR000466324
Spiraxin
UNII-L36O5T016N
Xifaxan
Xifaxan, Rifacol, Fatroximin, Rifaximin
Xifaxsan
Xifaxsan (TN)
Zaxine
alpha-0817185
3
Histamine PhosphateapprovedPhase 285251-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
EINECS 200-118-4
 
H0147
Histamine Positive Skin Test Control
Histamine Positive skin test control
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
4
butyric acidexperimentalPhase 210107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
5
histaminePhase 285275614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
6
Aluminum hydroxideapprovedPhase 1169
Synonyms:
Al(OH)3
Aluminiumhydroxid
 
Aluminum Hydroxide
Aluminum hydroxide
Dermadrox
7
Formaldehydeexperimental6550-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
8Ether49

Interventional clinical trials:

(show all 31)
idNameStatusNCT IDPhase
1Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in IsraelCompletedNCT00368316Phase 3
2Zinc Supplementation in Shigella PatientsCompletedNCT00321126Phase 3
3Rifaximin for Prevention of Travellers' DiarrheaCompletedNCT00742469Phase 3
4Therapeutic Induction of Endogenous AntibioticsCompletedNCT00800930Phase 2
5Healthy Adult Volunteer Study for Two Doses of a Shigella VaccineCompletedNCT00210288Phase 2
6Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine CandidateCompletedNCT01080716Phase 1, Phase 2
7Shigella Flexneri 2a Invaplex 50 Vaccine Dose Finding and Assessment of ProtectionCompletedNCT00485134Phase 1, Phase 2
8Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2aRecruitingNCT02646371Phase 2
9A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan AdultsNot yet recruitingNCT02676895Phase 2
10Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIbTerminatedNCT00866242Phase 2
11Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIaTerminatedNCT00866476Phase 2
12Shigella Sonnel O-SPC/rBRU Conjugate VaccineCompletedNCT01369927Phase 1
13Safety Study of Inactivated Shigella Whole Cell Vaccine in AdultsCompletedNCT01509846Phase 1
14Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMPCompletedNCT01531530Phase 1
15Safety and Immunogenicity of Two Live, Attenuated Oral Shigella Sonnei Vaccines: WRSs2 and WRSs3CompletedNCT01336699Phase 1
16A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults.CompletedNCT02017899Phase 1
17Evaluate a New Shigella Sonnei Vaccine Administered Either by Intradermal, Intranasal or Intramuscular Route in Healthy AdultsCompletedNCT02034500Phase 1
18Safety and Reactogenicity of Bioconjugate Vaccine to Prevent ShigellaCompletedNCT01069471Phase 1
19Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2aCompletedNCT02388009Phase 1
20Invaplex 50 Vaccine Dose-RangingCompletedNCT00082069Phase 1
21Effect of 15g Daily Consumption of NUTRIOSE on Healthy Volunteers Microbiota.CompletedNCT01897649Phase 1
22Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR) Administered Intranasally to Healthy, Adult VolunteersRecruitingNCT02445963Phase 1
23Phase 1 Study of dmLT ID Vaccination in Healthy AdultsNot yet recruitingNCT02531685Phase 1
24Shigella Sonnei OSPC-rDT Conjugate VaccineWithdrawnNCT01399424Phase 1
25The Long Term Clinical Course of Postinfectious Irritable Bowel Syndrome After Shigellosis; A 10 Year Follow up StudyCompletedNCT02516683
26Evaluation of a Diagnostic Enteric Card for Management of DiarrheaCompletedNCT00736567
27Experimental Phage Therapy of Bacterial InfectionsRecruitingNCT00945087
28Safety Study of Live Shigella Vaccine in Bangladeshi Adults and ChildrenActive, not recruitingNCT01813071
29A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty HospitalsActive, not recruitingNCT01612572
30Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive DisordersActive, not recruitingNCT02105714
31Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli InfectionsNot yet recruitingNCT01638039

Search NIH Clinical Center for Shigellosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Dysentery, Bacillary

Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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MalaCards organs/tissues related to Shigellosis:

33
Colon, T cells, Breast, Neutrophil, Appendix, Kidney, Testes

FMA organs/tissues related to Shigellosis:

16
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

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MGI Mouse Phenotypes related to Shigellosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.5CDC42, IL10, LTA, PFN1, SRC, VCL
2MP:00036317.4CASP1, CD79A, CDC42, CRK, IL10, LTA
3MP:00053847.3BTRC, CASP1, CD79A, CDC42, IL10, IRAK4
4MP:00053766.9CASP1, CD79A, CDC42, CRK, IL10, IRAK4
5MP:00053975.8BTRC, CASP1, CD79A, CXCL8, IL10, IRAK4
6MP:00053875.5BTRC, CASP1, CD79A, CXCL8, IL10, IRAK4

Publications for Shigellosis

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Articles related to Shigellosis:

(show top 50)    (show all 515)
idTitleAuthorsYear
1
Disparities of Shigellosis Rates among California Children by Race/Ethnicity and Census Tract Poverty Level, 2000-2010. (26020406)
2015
2
Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. (24680068)
2014
3
Investigation of key interventions for shigellosis outbreak control in China. (24736407)
2014
4
Use of population-based surveillance to define the high incidence of shigellosis in an urban slum in Nairobi, Kenya. (23505506)
2013
5
Systemic shigellosis in South Africa. (22474223)
2012
6
Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases. (22606962)
2012
7
A 9-year study of shigellosis in Northeast Malaysia: Antimicrobial susceptibility and shifting species dominance. (21654922)
2011
8
Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia. (21029529)
2010
9
Risk factors for sporadic shigellosis, FoodNet 2005. (20113209)
2010
10
Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh. (17554249)
2008
11
Comparison of cost-of-illness with willingness-to-pay estimates to avoid shigellosis: evidence from China. (18234703)
2008
12
Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the Peruvian Amazon. (18710884)
2008
13
High prevalence of CTX-M-15 extended-spectrum beta-lactamase among contacts of patients with shigellosis due to Shigella flexneri carrying CTX-M-15. (17646198)
2007
14
Risk factors for shigellosis in Thailand. (16997593)
2006
15
Azithromycin as an alternative to nalidixic acid in the therapy of childhood shigellosis. (15071299)
2004
16
Acceptability and accessibility of a Shigellosis vaccine in Nha Trang city of Viet Nam. (15473518)
2004
17
Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development. (15030306)
2003
18
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase. (11178905)
2001
19
Disease-dependent changes in T-cell populations in patients with shigellosis. (10843411)
2000
20
Pathogenesis of shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation and vaccine development. (10211438)
1998
21
Double-blind, randomized clinical trial for safety and efficacy of norfloxacin for shigellosis in children. (9099325)
1997
22
Pathogenesis and immune responses in shigellosis. (8993387)
1996
23
Prevalence of shigellosis in the U.S.: consistency with dose-response information. (8856376)
1996
24
Shigellosis: from molecular pathogenesis of infection to protective immunity and vaccine development. (9127893)
1996
25
Shigellosis in Thai children: experience from a rural hospital 1985-1993. (8629073)
1995
26
Epidemiological, clinical and microbiological features of shigellosis among hospitalized children in northern Israel. (7660077)
1995
27
Short-term pefloxacin therapy in Madagascan children with shigellosis due to multiresistant organisms. (7888566)
1994
28
Moose soup shigellosis in Alaska. (8048226)
1994
29
An outbreak of shigellosis in a slum colony of Delhi-1990. (8014439)
1993
30
Evaluation of an intervention program for the control of an outbreak of shigellosis among institutionalized persons. (8228351)
1993
31
Shigellosis complicated by perforated appendix. (8483634)
1993
32
Shigellosis in Thai children: epidemiologic, clinical and laboratory features. (1565537)
1992
33
From the Centers for Disease Control. Shigellosis in child day care centers--Lexington-Fayette County, Kentucky, 1991. (1640601)
1992
34
Shigellosis-associated encephalopathy. (1408493)
1992
35
Efficacy of norfloxacin for shigellosis: a double-blind randomised clinical trial. (1430968)
1992
36
Evaluation of indigenous plants in the treatment of acute shigellosis. (1816661)
1991
37
Potentials of Shigella flexneri Y strain TSF21 as a candidate vaccine against shigellosis: safety, immunogenicity and protective efficacy in Bonnet monkeys. (1878259)
1991
38
An outbreak of shigellosis aboard a cruise ship caused by a multiple-antibiotic-resistant strain of Shigella flexneri. (1652203)
1991
39
Shigellosis. (1861289)
1991
40
The use of hygiene, cohorting, and antimicrobial therapy to control an outbreak of shigellosis. (2405639)
1990
41
Single-dose ciprofloxacin for shigellosis. (1971401)
1990
42
Death in shigellosis: incidence and risk factors in hospitalized patients. (2313128)
1990
43
Recurrent shigellosis complicating human immunodeficiency virus infection: failure of pre-existing antibodies to confer protection. (2642653)
1989
44
Plasmid profile as a useful marker of a Shigella dysenteriae type 1 strain causing an epidemic of shigellosis. (3077946)
1988
45
A shigellosis outbreak traced to commercially distributed shredded lettuce. (3057879)
1988
46
Leads from the MMWR. Multiply resistant shigellosis in a day-care center--Texas. (3540326)
1987
47
Shigellosis in children. (3428993)
1987
48
Comparative efficacies of single intravenous doses of ceftriaxone and ampicillin for shigellosis in a placebo-controlled trial. (3518625)
1986
49
The relation between production of cytotoxin and clinical features in shigellosis. (3519788)
1986
50
Incidence of shigellosis among paediatric diarrhoeal disorders (a bacteriological study). (6491334)
1984

Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Pathways related to Shigellosis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CXCL8, SRC
29.5CDC42, SRC, VCL
3
Show member pathways
9.5CDC42, SRC, VCL
49.5CXCL8, IRAK4, LTA
59.5CRK, SRC, VCL
69.4CDC42, IRAK4, SRC
79.4BTRC, SRC
8
Show member pathways
9.4CDC42, CRK, SRC
99.4CDC42, CRK, SRC
109.4CDC42, CRK, SRC
119.4CDC42, CRK, SRC
129.3CRK, CXCL8, SRC
139.3CXCL8, IL10, VCL
14
Show member pathways
9.2CASP1, IRAK4, LTA, SRC
159.2CDC42, CRK, SRC, VCL
16
Show member pathways
9.2CDC42, CRK, SRC, VCL
179.2CDC42, CRK, SRC, VCL
18
Salmonella infection (KEGG)
Show member pathways
9.0CDC42, CRK, SRC, VCL
19
B cell receptor signaling pathway (KEGG)
Show member pathways
9.0CDC42, CRK, SRC, VCL
20
Show member pathways
8.7CDC42, CRK, PFN1, SRC, VCL
21
Show member pathways
8.7CDC42, CRK, PFN1, SRC, VCL
228.5CD79A, IL10, IRAK4, NOD1
23
Show member pathways
8.5BTRC, CASP1, IRAK4, NOD1
24
Show member pathways
8.3CASP1, CXCL8, IRAK4, NOD1, SRC
25
Show member pathways
8.3CDC42, CXCL8, LTF, NOD1, SRC
268.2CASP1, CXCL8, IL10, IRAK4, NOD1
27
Show member pathways
7.8CASP1, CDC42, CRK, CXCL8, IL10, LTA
286.8BTRC, CDC42, CRK, CXCL8, NOD1, PFN1
29
Show member pathways
6.4BTRC, CASP1, CD79A, CDC42, CRK, IRAK4

GO Terms for genes affiliated with Shigellosis

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Cellular components related to Shigellosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058296.4BTRC, CASP1, CDC42, CRK, IRAK4, NOD1
2cytoplasmGO:00057376.0CASP1, CDC42, CRK, IL10, IRAK4, LTF

Biological processes related to Shigellosis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell-cell adhesionGO:009013610.5CDC42, VCL
2negative regulation of growth of symbiont in hostGO:004413010.2IL10, LTA
3response to molecule of bacterial originGO:000223710.1CXCL8, IL10
4ephrin receptor signaling pathwayGO:00480139.9CDC42, CRK, SRC
5branching involved in mammary gland duct morphogenesisGO:00604449.9BTRC, SRC
6Fc-gamma receptor signaling pathway involved in phagocytosisGO:00380969.7CDC42, CRK, SRC
7positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.3CASP1, IRAK4, LTF, NOD1
8toll-like receptor signaling pathwayGO:00022249.1BTRC, IRAK4, NOD1
9MyD88-dependent toll-like receptor signaling pathwayGO:00027559.1BTRC, IRAK4, NOD1
10toll-like receptor 2 signaling pathwayGO:00341349.1BTRC, IRAK4, NOD1
11toll-like receptor 4 signaling pathwayGO:00341429.1BTRC, IRAK4, NOD1
12toll-like receptor 5 signaling pathwayGO:00341469.1BTRC, IRAK4, NOD1
13toll-like receptor 9 signaling pathwayGO:00341629.1BTRC, IRAK4, NOD1
14toll-like receptor 10 signaling pathwayGO:00341669.1BTRC, IRAK4, NOD1
15toll-like receptor TLR1:TLR2 signaling pathwayGO:00381239.1BTRC, IRAK4, NOD1
16toll-like receptor TLR6:TLR2 signaling pathwayGO:00381249.1BTRC, IRAK4, NOD1
17platelet activationGO:00301689.0CRK, PFN1, SRC, VCL
18blood coagulationGO:00075968.4CDC42, CRK, PFN1, SRC, VCL
19innate immune responseGO:00450877.6BTRC, CASP1, CDC42, CRK, IRAK4, NOD1
20signal transductionGO:00071657.2BTRC, CASP1, CDC42, CXCL8, IRAK4, LTA

Molecular functions related to Shigellosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein phosphorylated amino acid bindingGO:00453099.6BTRC, CRK
2cysteine-type endopeptidase activator activity involved in apoptotic processGO:00086569.4CASP1, NOD1

Sources for Shigellosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet