MCID: SHG001
MIFTS: 63

Shigellosis malady

Infectious diseases, Gastrointestinal diseases categories

Summaries for Shigellosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Shigellosis is an infectious disease caused by a group of bacteria called Shigella. Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. The diarrhea is often bloody. Shigellosis usually resolves in 5 to 7 days. Persons with shigellosis in the United States rarely require hospitalization. A severe infection with high fever may be associated with seizures in children less than 2 years old. Some persons who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others.

MalaCards: Shigellosis, also known as shigella flexneri infectious disease, is related to meningitis and influenza. An important gene associated with Shigellosis is VCL (vinculin), and among its related pathways are PAK Pathway and Apoptosis Modulation and Signaling. The drugs loperamide and bismuth subcarbonate and the compounds pentoxifylline and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and breast.

Disease Ontology:8 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.

Wikipedia:63 Shigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is... more...

Aliases & Classifications for Shigellosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
shigellosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

shigellosis 8 42 10 44 48
shigella flexneri infectious disease 8
shigella boydii infectious disease 8
shigella sonnei infectious disease 8
shigella gastroenteritis 8
dysentery, bacillary 60
shigella infections 60
bacillary dysentery 8


External Ids:

Disease Ontology8 DOID:12385
MeSH34 D004405
ICD9CM27 004.9, 004
SNOMED-CT via Orphanet57 36188001, 111817006
ICD10 via Orphanet26 A03.0, A03.1, A03.2 A03.3, A03.8, A03.9, more

Related Diseases for Shigellosis

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17GeneCards, 18GeneDecks
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Diseases related to Shigellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis29.8IL1B
2influenza29.8CASP1, LTA, LTF
3paratyphoid fever10.3
4dysentery10.3
5cholera10.3
6gastroenteritis10.3
7irritable bowel syndrome10.2
8hemolytic-uremic syndrome10.2
9diarrhea10.2
10reactive arthritis10.2
11arthritis10.2
12typhoid fever10.1
13hepatitis10.1
14acute diarrhea10.0
15campylobacteriosis10.0
16toxic encephalopathy10.0
17appendicitis10.0
18measles10.0
19listeriosis10.0
20hepatitis a10.0
21intestinal disease10.0
22pneumonia10.0
23septic shock10.0CASP1, LTA, LTF, IL1R1, IL1B
24periodontitis10.0LTA, LTF, IL1R1, IL1B
25familial cold autoinflammatory syndrome10.0IL1B, IL1R1, CASP1
26monocytic leukemia10.0CASP1, LTF, IL1R1, IL1B
27chronic infantile neurological cutaneous articular syndrome10.0IL1B, IL1R1, CASP1
28sepsis10.0IL1B, IL1R1, LTF, LTA, CASP1
29muckle-wells syndrome10.0CASP1, IL1R1, IL1B
30inflammatory bowel disease10.0CASP1, LTA, LTF, IL1R1, IL1B
31cerebral malaria10.0IL1R1, IL1B, VCL
32familial mediterranean fever10.0IL1B, CASP1, CARD17
33sjogren's syndrome10.0LTF
34cowpox10.0PFN3, CASP1, CARD17
35bacterial vaginosis10.0IL1B, IL1R1, LTF
36pulmonary fibrosis10.0IL1B
37synovitis10.0IL1B, IL1R1
38crohn's disease10.0LTF
39gingivitis10.0IL1B, LTF
40myocardial infarction10.0CASP1, VCL
41chorioamnionitis10.0IL1B, IL1R1, LTF
42pemphigus vulgaris10.0VCL
43mastitis10.0IL1B, LTF
44endometriosis10.0IL1B, IL1R1
45sarcoidosis10.0IL1B, LTA
46allergic rhinitis10.0PFN4
47ulcerative colitis10.0LTF
48alzheimer's disease10.0IL1B, CASP1
49arthropathy10.0IL1B
50tuberculosis10.0IL1B

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Clinical Features for Shigellosis

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Drugs & Therapeutics for Shigellosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Shigellosis:

32
Colon, Breast, T cells, Testes, Brain, Kidney, Appendix

FMA organs/tissues related to Shigellosis:

14
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

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Publications for Shigellosis

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Sources:
50PubMed
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Articles related to Shigellosis:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Housefly population density correlates with shigellosis among children in Mirzapur, Bangladesh: a time series analysis. (23818998)
2013
2
Dynamics of shigellosis epidemics: estimating individual-level transmission and reporting rates from national epidemiologic data sets. (24008913)
2013
3
The Recent Trends of Shigellosis: A JIPMER Perspective. (23285433)
2012
4
A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children. (21829747)
2011
5
Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia. (21029529)
2010
6
High-throughput screening of the virulence regulator VirF: a novel antibacterial target for shigellosis. (20237205)
2010
7
Case-control study of shigellosis in San Francisco: the role of sexual transmission and HIV infection. (17205436)
2007
8
The epidemiology of travel-associated shigellosis--regional risks, seasonality and serogroups. (16230220)
2005
9
Randomized comparison of azithromycin versus cefixime for treatment of shigellosis in children. (12712971)
2003
10
Changing trends in shigellosis at a tertiary care centre. (15022943)
2003
11
Rate of seizures in children with shigellosis. (11883810)
2002
12
A report of an outbreak of Shigellosis in a primary school in Staffordshire. (11464304)
2001
13
Hyperimmune bovine colostrum in the treatment of shigellosis in children: a double-blind, randomized, controlled trial. (11853331)
2001
14
Treatment of shigellosis with cefixime: two days vs. five days. (10877166)
2000
15
Application of a geographic information system to the tracking and control of an outbreak of shigellosis. (11017823)
2000
16
Fly control and shigellosis. (10459947)
1999
17
Short-chain fatty acids improve clinical, pathologic, and microbiologic features of experimental shigellosis. (9878023)
1999
18
Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis. (10024597)
1999
19
Clinical aspects of shigellosis in reference of sigmoidoscopic findings and histopathological changes of the colon. (10211433)
1998
20
Utility of a polymerase chain reaction diagnostic system in a study of the epidemiology of shigellosis among dysentery patients, family contacts, and well controls living in a shigellosis-endemic area. (9333160)
1997
21
Early feeding of an energy dense diet during acute shigellosis enhances growth in malnourished children. (9040543)
1997
22
Alterations in lymphocyte phenotype and function in children with shigellosis who develop complications. (8991634)
1996
23
Epidemiological, clinical and microbiological features of shigellosis among hospitalized children in northern Israel. (7660077)
1995
24
Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation. (7829006)
1994
25
Evaluation of an intervention program for the control of an outbreak of shigellosis among institutionalized persons. (8228351)
1993
26
Rapid catch-up growth of children fed a high-protein diet during convalescence from shigellosis. (8438780)
1993
27
Relationship between humoral immune responses and oral temperature during human shigellosis. (8501337)
1993
28
From the Centers for Disease Control. Shigellosis in child day care centers--Lexington-Fayette County, Kentucky, 1991. (1640601)
1992
29
Childhood shigellosis in Saudi Arabia. (1565538)
1992
30
Rethinking options for the treatment of shigellosis. (1452488)
1992
31
An outbreak of shigellosis aboard a cruise ship caused by a multiple-antibiotic-resistant strain of Shigella flexneri. (1652203)
1991
32
Epidemiologic aspects of shigellosis and other causes of dysentery in Thailand. (2047642)
1991
33
Shigellosis: a killer disease. (2193715)
1990
34
Periparturitional shigellosis. (2215779)
1990
35
Shigellosis winter trends in Milwaukee. (2786286)
1989
36
Causes of death and the histopathologic findings in fatal shigellosis. (2594452)
1989
37
Shigellosis occurring in newborn nursery staff. (2654287)
1989
38
Role of M cells in initial antigen uptake and in ulcer formation in the rabbit intestinal loop model of shigellosis. (2645214)
1989
39
Shigellosis in adults: epidemiologic, clinical, and laboratory features. (2739562)
1989
40
Shigellosis in the nursery. (2715626)
1989
41
A shigellosis outbreak traced to commercially distributed shredded lettuce. (3057879)
1988
42
Persistent shigellosis. (3058558)
1988
43
Epidemiological and clinical characteristics of shigellosis in rural Bangladesh. (3251937)
1988
44
A steep decline of death in a shigellosis epidemic in Bangladesh by a community--participated intervention. (3270455)
1988
45
Shigellosis at a Caribbean resort. Hamburger and North American origin as risk factors. (3318410)
1987
46
Shigellosis outbreak associated with swimming. (3541651)
1987
47
To shigellosis epidemicity in East-Slovakian region. (3886785)
1985
48
Shigellosis in day care centers: use of plasmid analysis to assess control measures. (6344045)
1983
49
Convulsions in shigellosis. Evaluation of possible risk factors. (6613944)
1983
50
Shigellosis with bacteremia: a report of two cases and a review of the literature. (6340078)
1983

Genetic Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Shigellosis

Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 12EMD Millipore, 59Tocris Bioscience, 55SinoBiological
See all sources

Pathways related to Shigellosis according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CASP1, MAPK12, LTA, IL1R1, IL1B, VCL
2
Hide members
10.5IL1R1, LTA, CASP1
310.5IL1R1, IL1B, VCL
4
Hide members
10.5IL1B, IL1R1, CASP1
5
Hide members
10.5CASP1, IL1R1, IL1B
610.5LTA, IL1R1, IL1B
7
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B, VCL
8
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
9
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
10
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
1110.5IL1B, CASP1
1210.5ARPC4, ARPC5L, RHOG, VCL
13
Hide members
10.5ARPC4, ARPC5L, PFN4, PFN3, VCL
14
Hide members
10.5CASP1, ARPC4, MAPK12, MAPK13, VASP, IL1R1
15
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1B
16
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1B
17
Hide members
10.5CASP1, MAPK12, MAPK13, IL1R1, IL1B
18
Hide members
10.5CASP1, MAPK12, MAPK13, IL1R1, IL1B
19
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B
20
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B
2110.5IL1B, CASP1, PFN3, PFN4, MAPK13, MAPK12
22
Hide members
10.5CASP1, MAPK12, MAPK13, LTA
2310.5ARPC4, ARPC5L, VASP
2410.5ARPC4, ARPC5L, RHOG, MAPK12, MAPK13, PFN4
25
Immune response IFN gamma signaling pathway
Hide members
10.5CASP1, MAPK12, MAPK13, IL1B
26
Hide members
10.5IL1B, MAPK13, MAPK12, CASP1
2710.5IL1B, MAPK13, MAPK12, CASP1
2810.5MAPK12, MAPK13, LTA, IL1B
29
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
30
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
31
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
3210.5MAPK12, MAPK13, IL1R1, IL1B
33
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
3410.5VCL, VASP, MAPK13, MAPK12
35
Hide members
10.5VCL, VASP, MAPK13, MAPK12
36
Hide members
10.5MAPK13, MAPK12, CASP1
37
Hide members
10.5MAPK13, MAPK12, CASP1
38
Hide members
10.5MAPK13, MAPK12, CASP1
3910.5MAPK12, MAPK13, IL1B
4010.5MAPK13, MAPK12
4110.5MAPK13, MAPK12
4210.5MAPK12, MAPK13
4310.5MAPK13, MAPK12, ARPC4

Compounds for genes affiliated with Shigellosis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB
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Compounds related to Shigellosis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.9IL1B, IL1R1, LTF, LTA, CASP1
2endotoxin4410.9CASP1, LTA, LTF, IL1R1, IL1B
3tenidap44 2811.9LTF, IL1R1, IL1B
4neopterin4410.9LTA, LTF, IL1R1, IL1B
5anakinra44 1111.9IL1B, IL1R1, CASP1
6indomethacin44 59 28 1113.9LTA, LTF, VASP, IL1R1, IL1B
7as 10159 4411.9IL1B, IL1R1, CASP1
8minocycline44 1111.9CASP1, LTF, IL1B
9actinomycin d4410.9CASP1, LTA, LTF, IL1R1, IL1B
10cuprophan4410.9IL1B, IL1R1, CASP1
11acetyl-tyr-val-ala-asp-cho4410.9CASP1, IL1B
12lipoteichoic acid4410.9IL1B, IL1R1, LTA
13hyaluronic acid44 2411.9IL1B, IL1R1, LTF, LTA
14sb 20358044 5911.9IL1B, IL1R1, MAPK13, MAPK12, CASP1
15vegf4410.9CASP1, LTA, LTF, IL1R1, IL1B, VCL
16serine4410.9CASP1, MAPK12, MAPK13, LTA, LTF, VASP
17etanercept44 49 1112.9LTA, IL1R1, IL1B
18pge24410.9CASP1, LTA, LTF, IL1R1, IL1B
19il 104410.9LTA, IL1R1, IL1B
20nitric oxide44 11 2412.9CASP1, LTA, VASP, IL1R1, IL1B, VCL
21infliximab44 49 1112.9IL1B, IL1R1, LTA
22diphenyleneiodonium4410.8IL1B, IL1R1, CASP1
23peptidoglycan44 2811.8CASP1, IL1R1, IL1B
24threonine4410.8CASP1, MAPK12, LTA, VASP, IL1R1, VCL
25ivig4410.8IL1B, IL1R1, LTA
26aspirin44 49 28 2413.8CASP1, VASP, IL1R1, IL1B
27cycloheximide4410.8CASP1, LTA, IL1R1, IL1B, VCL
28ibuprofen44 28 49 11 2414.8IL1B, IL1R1, LTF
29n acetylcysteine4410.8IL1B, IL1R1, LTF, CASP1
30tlck4410.8CASP1, IL1B
3112-o-tetradecanoylphorbol 13-acetate4410.7MAPK13, LTA, IL1R1, VCL
32muramyl dipeptide44 2811.7CASP1, IL1B
33ag-1264410.7CASP1, IL1B
34h2o24410.7CASP1, LTA, LTF, IL1R1, VCL
35monosodium urate4410.7IL1R1, IL1B
36fibrinogen4410.7VCL, IL1R1, VASP, LTF
37leukotriene b444 59 2412.6LTF, IL1R1, IL1B
38toxin-14410.6LTA, IL1B
394-ipp5910.5IL1R1, IL1B
40gold sodium thiomalate4410.5IL1B, IL1R1
41git 275910.4IL1R1, IL1B
42cytochalasin4410.2LTF, VCL

GO Terms for genes affiliated with Shigellosis

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Sources:
16Gene Ontology
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Cellular components related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.5ARPC4, RHOG, MAPK12, MAPK13, BLOC1S3, VASP
2cytoskeletonGO:00585610.2VCL, PFN3, PFN4, ARPC5L, CCIN

Biological processes related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.5IL1B, CASP1
2cellular response to organic substanceGO:07131010.5IL1B, CASP1
3lymph node developmentGO:04853510.4CD248, LTA
4response to ATPGO:03319810.2IL1B, CASP1

Molecular functions related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase activityGO:00470710.5MAPK13, MAPK12
2actin bindingGO:00377910.2VCL, VASP, PFN3, PFN4, ARPC5L

Products for genes affiliated with Shigellosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Shigellosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet