Shigellosis malady

CDC: Shigellosis is an infectious disease caused by a group of bacteria called Shigella. Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. The diarrhea is often bloody. Shigellosis usually resolves in 5 to 7 days. Persons with shigellosis in the United States rarely require hospitalization. A severe infection with high fever may be associated with seizures in children less than 2 years old. Some persons who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others.²

MalaCards: Shigellosis, also known as shigella flexneri infectious disease, is related to dysentery and meningitis. An important gene associated with Shigellosis is VCL (vinculin), and among its related pathways are Cytoskeleton remodeling CDC42 in cellular processes and Immune response_Role of DAP12 receptors in NK cells. The drugs bismuth subgallate and loperamide hydrochloride and the compounds sp 600125 and pge2 have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon and colon, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology: A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.⁶

Wikipedia: Shigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is...⁴⁴ more...

Aliases & Descriptions:

shigellosis 6 30 8 32 shigella flexneri infectious disease 6 disease caused by shigella flexneri 43 shigella boydii infectious disease 6 shigella sonnei infectious disease 6 disease caused by shigella boydii 43

disease caused by shigella sonnei 43 shigella gastroenteritis 6 dysentery, bacillary 43 shigella infections 43 bacillary dysentery 6

Diseases related to shigellosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 396)

id	Related Disease	Score	Top Affiliating Genes
1	dysentery	31.0	VIPR1, QTRT1, CD79A, IGF1
2	meningitis	26.0	VDAC1, MPO, CD79A, CD248, IRAK4, IL1B
3	cholesterol	18.5	RELA, WASL, VDAC1, VASP, RAC1, CLDN11
4	familial cold autoinflammatory syndrome	14.0	IL1B, IL1R1, CASP1
5	paratyphoid fever	13.9	IL1B, IL1R1, CASP1, SUMF2
6	spinocerebellar ataxia autosomal recessive 1	13.7	WAS, WASF1, WASL, ACTA1
7	acute graft versus host disease	13.7	IL18, IL1R1, NOD2, LTA
8	hypohidrotic ectodermal dysplasia	13.7	CHUK, IRAK4, IKBKG, NFKBIA
9	malignant histiocytosis	13.6	IL1B, IL1R1, F2, LTA
10	cowpox	13.5	IL18, CASP3, CASP1, CARD17, PFN3
11	cinca syndrome	13.5	IL18, IL1B, IL1R1, IL1RAPL2, CASP1
12	chronic infantile neurological cutaneous articular syndrome	13.5	IL18, IL1B, IL1R1, IL1RAPL2, CASP1
13	cerebral malaria	13.5	VCL, IL1B, IL1R1, IL1RAPL2
14	intrauterine infections	13.5	IL1B, IL1R1, IL8, LTF
15	collagenous colitis	13.4	MPO, CD79A, NOD2, LTF
16	blau syndrome	13.4	IL1B, IL1RAPL2, NOD1, NOD2
17	adult-onset still's disease	13.4	IL18, IL1R1, IL1RAPL2
18	typhoid fever	13.4	VDAC1, CD79A, IL1B, IL1R1, F2, CASP1
19	mastitis	13.3	IL1B, IL1R1, IL8, SUMF2, NOD2, LTF
20	ectodermal dysplasia	13.2	CHUK, IRAK4, IL18, IL1B, IKBKG, NFKB1
21	psoriatic arthritis	13.2	IL1B, IL1RAPL2, NOD2, NFKBIA
22	muckle-wells syndrome	13.1	IL1B, IL1R1, IL1RAPL2, IL8, CASP1
23	wells syndrome	13.1	IL1B, IL1R1, IL1RAPL2, IL8, CASP1
24	idiopathic pulmonary fibrosis	13.1	MPO, IL1B, IL1R1, IL8
25	peripheral t-cell lymphoma	13.1	RELA, CD44, IL1B, NFKB1, LTA, ABL1
26	eczema	13.1	WAS, WASL, MPO, CD79A, IL18, CAMP
27	schnitzler syndrome	13.0	IL18, IL1R1, IL1RAPL2
28	bacterial vaginosis	13.0	IL1B, IL1R1, IL1RAPL2, IL8, LTF
29	gastroenteritis	13.0	VDAC1, CD79A, CD248, IL1B, IL8, SUMF2
30	retinopathy of prematurity	13.0	IL18, IL1B, MAPK8, IKBKG, IGF1
31	acute biphenotypic leukemia	13.0	MPO, F2, ABL1
32	aseptic meningitis	13.0	IL1B, IL1R1, IL8, SOD1
33	q fever	13.0	CD79A, IL1B, IL1R1, IL1RAPL2, F2
34	chronic myeloproliferative disease	12.9	MPO, IL1B, F2, ABL1
35	reactive arthritis	12.9	CD79A, IL18, IL1B, IL8, LTF
36	spondylarthropathy	12.9	IL1B, IL1RAPL2, IL8, NOD2, LTA
37	respiratory failure	12.9	IL1B, IL1R1, IL8, F2, LTA, ACTA1
38	pancreatic ductal carcinoma	12.9	VCL, MXI1, CD44, IL1B, MAPK8, MAPK9
39	common variable immunodeficiency	12.9	MPO, CD79A, IL1B, IL1R1, RPA1, LTF
40	acute lymphocytic leukemia	12.9	WASF1, MPO, MAPK8, CRKL, NFKB1, LTA
41	periodontitis	12.8	MPO, IL1B, IL1R1, IL1RAPL2, IL8, LTA
42	idiopathic myopathy	12.8	RELA, IL1R1, IL1RAPL2, NFKB1, NFKBIA
43	febrile seizures	12.8	IL1B, IL1R1, IL1RAPL2, IL8, CASP1
44	retinal vein occlusion	12.8	CD79A, IL18, IL1B, IL1R1, IL8, F2
45	adult respiratory distress syndrome	12.8	MPO, IL1B, IL8, LTA
46	ovarian hyperstimulation syndrome	12.8	CD79A, IL18, IL1B, IL1R1, IL8, F2
47	leptospirosis	12.7	CD79A, IL18, IL1B, IL1R1, F2
48	juvenile rheumatoid arthritis	12.7	CD79A, IL1B, IL1R1, IL8, LTA, SOD1
49	hemolytic-uremic syndrome	12.7	CD79A, IL1B, IL1R1, IL8, MCHR2, F2
50	inclusion body myositis	12.7	RELA, CD79A, IL1R1, IL1RAPL2, CASP1, NFKB1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 ampicillin, ampicillin sodium, ampicillin trihydrate, bismuth, bismuth hydroxide, bismuth resorcin compound, bismuth subcarbonate, bismuth subcarbonate pwdr [va product], bismuth subcitrate, bismuth subgallate, bismuth subiodide, bismuth subnitrate, bismuth subnitrate pwdr [va product], bismuth subsalicylate, bismuth-formic-iodide, furazolidone, loperamide, loperamide hydrochloride

MalaCards organs/tissues related to shigellosis:

²²

FMA organs/tissues related to shigellosis:

¹¹

MGI Mouse Phenotypes related to shigellosis:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	ROCK1, HIF3A, DOCK1
2	craniofacial phenotype	MP:0005382	9.9	CRKL, DIAPH1, MAPK9, MAPK8, BLOC1S3
3	endocrine/exocrine gland phenotype	MP:0005379	9.8	GALP, STX2, ELMO1, LTA, CRKL, CDC42
4	liver/biliary system phenotype	MP:0005370	9.4	ABL1, ACTA1, ACTB, STX2, SOD1, IKBKG
5	hematopoietic system phenotype	MP:0005397	9.3	CHUK, BTRC, WAS, MXI1, ATG5, IRAK4
6	limbs/digits/tail phenotype	MP:0005371	8.4	LTA, PFN1, CRKL, SRC, IGF1, IKBKB
7	hearing/vestibular/ear phenotype	MP:0005377	8.0	ACTG1, ACTB, NFKB1, CRKL, CASP3, IGF1
8	tumorigenesis	MP:0002006	8.0	MAPK9, IKBKG, IGF1, CASP1, SRC, CRKL
9	integument phenotype	MP:0010771	8.0	F2, DIAPH1, SRC, CRKL, NFKBIA, SLC4A1
10	embryogenesis phenotype	MP:0005380	7.9	DOCK1, SRC, CTTN, CRKL, PFN1, ABL1
11	reproductive system phenotype	MP:0005389	7.8	CASP3, CASP1, SRC, CTTN, ACTB, STX2
12	normal phenotype	MP:0002873	7.6	MAPK11, IKBKB, IKBKG, IGF1, F2, NFKBIA
13	digestive/alimentary phenotype	MP:0005381	7.2	IKBKB, IKBKG, F2, CASP3, CASP1, CRK
14	skeleton phenotype	MP:0005390	7.2	CASP3, DIAPH1, SRC, CRKL, NOD2, NFKB1
15	vision/eye phenotype	MP:0005391	7.2	LTA, CRKL, SRC, CASP3, ABL1, ACTA1
16	immune system phenotype	MP:0005387	7.1	NFKBIB, NFKBIA, NLRX1, RPA1, NOD2, NOD1
17	behavior/neurological phenotype	MP:0005386	5.9	PFN2, PFN1, NFKB1, SRC, CASP3, IKBKG
18	mortality/aging	MP:0010768	5.8	ROCK2, ROCK1, SLC4A1, STX1A, ST8SIA2, ACTG1
19	muscle phenotype	MP:0005369	5.5	VCL, RAC1, ATG5, MPO, CDC42, CD44
20	growth/size phenotype	MP:0005378	4.5	NFKB1, CD44, CDC42, ATG5, CHUK, RAC1
21	nervous system phenotype	MP:0003631	3.5	LTA, ABL1, ACTB, ACTG1, ST8SIA2, STX1A
22	cardiovascular system phenotype	MP:0005385	3.3	ROCK2, MAPK1, MAPK11, MAPK10, MAPK14, MAPK3
23	cellular phenotype	MP:0005384	2.5	MAPK1, VASP, VCL, VIPR1, BTRC, WASL
24	homeostasis/metabolism phenotype	MP:0005376	2.5	GALP, ROCK1, SLC4A1, SOD1, STX1A, ACTB

Articles related to shigellosis:

id	Title	Authors	Year	Affiliating Genes
1	Very late-onset group B Streptococcus meningitis, sep sis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency. (19814626)	Krause J.C.... Creech C.B.	2009	IRAK4
2	New animal model of shigellosis in the Guinea pig: it s usefulness for protective efficacy studies. (17277155)	Shim D.H.... Kweon M.N.	2007	IL1B
3	Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. (16740661)	Raqib R.... Agerberth B.	2006	CAMP
4	Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2. (12011015)	Raqib R.... Andersson J.	2002	CASP1, CASP3, IL18
5	Innate immune responses in children and adults with Shigellosis. (10816520)	Raqib R.... Andersson J.	2000	SOD1, MPO, LTF
6	A systemic downregulation of gamma interferon production is associated with acute shigellosis. (9393836)	Raqib R.... Bakhiet M.	1997	LTA
7	Brodifacoum rodenticide ingestion in a patient with shigellosis. (9258313)	Stanziale S.F.... Fisher R.B.	1997	F2
8	Immunoglobulin subclass distribution and dynamics of Shigella-specific antibody responses in serum and stool samples in shigellosis. (7729920)	Islam D.... Christensson B.	1995	CD79A
9	Role of interleukin-1 in the pathogenesis of experimental shigellosis. (7635983)	Sansonetti P.J.... Huerre M.	1995	IL1R1, IL1RAPL2
10	The effect of dietary protein supplementation on insulin-like growth factors (IGFs) and IGF-binding proteins in children with shigellosis. (7505287)	Pucilowska J.B.... Underwood L.E.	1993	IGF1

Genes related to shigellosis according to GeneCards:

(show top 50)    (show all 110)

id	Symbol	Description	Score	GeneCards Section Context
1	VCL	vinculin	11.0	Pathways & Interactions
2	VASP	vasodilator-stimulated phosphoprotein	11.0
3	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
4	CASP1	caspase 1, apoptosis-related cysteine peptidase	11.0	Publications
5	IL1R1	interleukin 1 receptor, type I	11.0	Publications
6	LTF	lactotransferrin	11.0	Publications
7	IL1B	interleukin 1, beta	11.0	Publications
8	CCIN	calicin	11.0
9	MORF4	mortality factor 4	11.0
10	PFN3	profilin 3	11.0	Pathways & Interactions
11	PFN4	profilin family, member 4	11.0	Pathways & Interactions
12	CARD17	caspase recruitment domain family, member 17	11.0	Disorders
13	GOLGA6B	golgin A6 family, member B	11.0
14	BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	11.0
15	ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	11.0	Pathways & Interactions
16	PFN2	profilin 2	11.0	Pathways & Interactions
17	ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	11.0	Pathways & Interactions
18	ARPC5L	actin related protein 2/3 complex, subunit 5-like	11.0	Pathways & Interactions
19	RHOG	ras homolog family member G	11.0	Pathways & Interactions
20	ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	11.0	Pathways & Interactions
21	ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	11.0	Pathways & Interactions
22	SECTM1	secreted and transmembrane 1	11.0
23	GALP	galanin-like peptide	11.0
24	SUMF2	sulfatase modifying factor 2	11.0
25	MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	11.0	Pathways & Interactions
26	CD248	CD248 molecule, endosialin	11.0
27	MYOZ3	myozenin 3	11.0
28	KCP	kielin/chordin-like protein	11.0
29	NLRX1	NLR family member X1	11.0
30	QTRT1	queuine tRNA-ribosyltransferase 1	11.0
31	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	11.0	Pathways & Interactions
32	PFN1	profilin 1	11.0	Pathways & Interactions
33	ARPC1A	actin related protein 2/3 complex, subunit 1A, 41kDa	11.0	Pathways & Interactions
34	FLII	flightless I homolog (Drosophila)	11.0
35	CLDN11	claudin 11	11.0
36	POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	11.0
37	HCLS1	hematopoietic cell-specific Lyn substrate 1	11.0	Pathways & Interactions
38	NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	11.0	Pathways & Interactions
39	TRIM27	tripartite motif containing 27	11.0
40	MAPK13	mitogen-activated protein kinase 13	11.0	Pathways & Interactions
41	MAPK12	mitogen-activated protein kinase 12	11.0	Pathways & Interactions
42	CYTH4	cytohesin 4	11.0
43	POLR2F	polymerase (RNA) II (DNA directed) polypeptide F	11.0
44	RIPK2	receptor-interacting serine-threonine kinase 2	11.0	Pathways & Interactions
45	WAS	Wiskott-Aldrich syndrome	11.0	Pathways & Interactions
46	UBE2D2	ubiquitin-conjugating enzyme E2D 2	11.0	Pathways & Interactions
47	WASL	Wiskott-Aldrich syndrome-like	11.0	Pathways & Interactions
48	WASF2	WAS protein family, member 2	11.0	Pathways & Interactions
49	CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	11.0	Pathways & Interactions
50	MAPK11	mitogen-activated protein kinase 11	11.0	Pathways & Interactions

Pathways related to shigellosis according to GeneDecks:

(show top 50)    (show all 427)

id	Pathway	Score	Top Affiliating Genes
1	Cytoskeleton remodeling CDC42 in cellular processes10	10.4	WAS, WASL, CDC42, ACTG1, ACTB, ARPC5
2	Immune response_Role of DAP12 receptors in NK cells41	10.3	ACTG1, ACTB, CRKL, ARPC5, ARPC2, ARPC1A
3	Cell adhesion_Cadherin-mediated cell adhesion41	10.0	ARPC1A, ARPC3, ARPC1B, ARPC4, CDC42, WASL
4	G-protein signaling RAC1 in cellular process10	9.9	ACTG1, ACTB, ARPC5, ARPC2, ARPC1A, ARPC3
5	RIG-I-like receptor signaling pathway20	9.9	MAPK11, MAPK10, MAPK13, MAPK12, MAPK8, CHUK
6	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases10	9.8	RAC1, WASF1, WAS, CDC42, ACTG1, ACTB
7	Neurophysiological process_Receptor-mediated axon growth repulsion41	9.8	ROCK2, ROCK1, ACTG1, ACTB, CTTN, SRC
8	Pathogenic Escherichia coli infection20	9.7	HCLS1, CDC42, WASL, WAS, ITGB1, ARPC4
9	CD28 Signaling in T-Helper Cell36	9.5	RAC1, CDC42, ACTG1, ACTB, ACTA1, NFKBIB
10	Development_Slit-Robo signaling41	9.5	ROCK2, ROCK1, ACTG1, ACTB, ACTA1, ABL1
11	Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility41	9.5	SRC, ARPC5, ARPC2, ARPC1A, ARPC3, ARPC1B
12	Fc gamma R-mediated phagocytosis20	9.4	ARPC4, CDC42, RAC1, VASP, WASL, WASF2
13	Cellular Transformation by HTLV136	9.4	LTA, NFKBIB, NFKBIA, NFKB1, IKBKG, IKBKB
14	Bacterial invasion of epithelial cells20	9.2	HCLS1, ELMO1, ACTG1, ACTB, RHOG, CRKL
15	Development_Flt3 signaling41	9.1	MAPK13, MAPK8, CDC42, RAC1, MAPK14, MAPK11
16	CD40 Signaling36	9.0	MAPK10, MAPK13, MAPK12, MAPK8, MAPK11, MAPK1
17	Regulation of actin cytoskeleton20	9.0	ROCK2, ARPC5, ARPC5L, ARPC2, ARPC1A, ARPC3
18	Development A2A receptor signaling10	8.9	RELA, CHUK, NFKBIB, IKBKB, MAPK9, MAPK11
19	BAFF in B-Cell Signaling36	8.9	NFKBIB, CHUK, MAPK8, NFKBIA, NFKB1, IKBKG
20	IL-1 Pathway36	8.8	MAPK12, MAPK8, IL1R1, IL1B, IRAK4, CHUK
21	NGF Pathway36	8.8	RAC1, CHUK, CDC42, ROCK2, ROCK1, IKBKG
22	Toll Comparative Pathway36	8.8	IRAK4, CHUK, MAPK8, MAPK12, NFKBIB, NFKBIA
23	Immune response CCR3 signaling in eosinophils10	8.7	ROCK2, ROCK1, ACTG1, ACTB, PFN2, ARPC1B
24	NF-KappaB Activation by EBV36	8.7	POLR2C, NFKBIA, NFKB1, IKBKG, IKBKB, MAPK9
25	G-protein signaling_Ras family GTPases in kinase cascades (scheme)41	8.6	MAPK9, MAPK1, MAPK11, MAPK10, MAPK14, MAPK3
26	G-protein signaling Ras family GTPases in kinase cascades (scheme)10	8.6	MAPK8, CDC42, RAC1, MAPK12, MAPK13, MAPK9
27	Apoptosis through Death Receptors36	8.5	ACTG1, ACTB, ACTA1, NFKBIB, NFKBIA, NFKB1
28	Development Flt3 signaling10	8.5	RAC1, CRKL, CRK, SRC, MAPK1, MAPK11
29	Inflammasome Activation Pathways37	8.5	MAPK11, MAPK10, MAPK14, MAPK13, MAPK12, MAPK8
30	Toll-Like Receptor Signaling Pathways37	8.4	NFKBIB, NFKBIA, NFKB1, IKBKG, IKBKB, MAPK9
31	Immune response_IL-1 signaling pathway41	8.4	NFKBIB, NFKBIA, NFKB1, IKBKG, IKBKB, MAPK9
32	SUMO Pathway36	8.4	MAPK10, MAPK14, MAPK13, MAPK12, MAPK8, IL1R1
33	Apoptosis and survival_Lymphotoxin-beta receptor signaling41	8.4	MAPK8, IL8, CHUK, RELA, MAPK10, MAPK9
34	TLR-TRIF Pathway36	8.4	MAPK12, MAPK8, IRAK4, MAPK13, NFKBIB, NFKBIA
35	Apoptosis and survival Lymphotoxin-beta receptor signaling10	8.4	NFKB1, CASP3, IKBKG, IKBKB, MAPK9, MAPK10
36	Immune response_MIF in innate immunity response41	8.3	MAPK11, MAPK10, MAPK14, MAPK13, MAPK12, MAPK8
37	G-protein signaling_G-Protein alpha-12 signaling pathway41	8.3	ROCK2, ROCK1, MAPK9, MAPK1, MAPK11, MAPK10
38	TREM1 Pathway36	8.1	MAPK1, CHUK, MAPK11, MAPK10, MAPK14, MAPK3
39	Development A1 receptor signaling10	8.0	NFKBIB, NFKBIA, NFKB1, SRC, IKBKB, MAPK1
40	RANK Signaling in Osteoclasts36	7.7	NFKBIA, NFKB1, SRC, IKBKG, IKBKB, MAPK9
41	Immune response_Fc epsilon RI pathway41	7.7	MAPK3, MAPK13, MAPK12, MAPK8, CHUK, RAC1
42	HMGB1 Pathway36	7.7	NFKB1, MAPK9, MAPK1, MAPK11, MAPK10, MAPK14
43	IL-2 Pathway36	7.6	MAPK3, MAPK13, MAPK12, MAPK8, CHUK, MAPK14
44	TGF-beta Signaling Pathways37	7.6	MAPK11, MAPK10, MAPK14, MAPK3, MAPK13, MAPK12
45	Chagas disease (American trypanosomiasis)20	7.5	IKBKG, IRAK4, CHUK, RELA, IL1B, IL8
46	Neurotrophin signaling pathway20	7.3	MAPK11, MAPK10, MAPK14, MAPK3, MAPK13, MAPK12
47	Tuberculosis20	7.2	RIPK2, NFKB1, NOD2, SRC, CAMP, CASP3
48	Pertussis20	7.2	NOD1, IL1B, IRAK4, ITGB1, ITGA5, RELA
49	14-3-3 Induced Apoptosis36	7.2	MAPK3, MAPK13, MAPK12, MAPK8, IL1R1, IL1B
50	Shigellosis20	4.2	MAD2L2, ITGB1, ITGA5, CD44, CDC42, ATG5

Compounds related to shigellosis according to GeneDecks:

(show top 50)    (show all 198)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.1	CASP3, IKBKB
2	pge232	9.9	LTF, CAMP, RAC1, IL1RAPL2, MAPK10, IKBKB
3	threonine32	9.9	RIPK2, STX1A, LTA, NOD2, CRKL, CRK
4	peptidoglycan32	9.7	ACTA1, RIPK2, NOD2, NOD1, CASP1, IL8
5	sulfasalazine32 9 9	11.6	MPO, CHUK, IL1RAPL2, IKBKB, IL1R1, NFKBIA
6	pentoxifylline32 9 9	11.5	CAMP, NFKBIA, LTA, LTF, CASP1, IL1RAPL2
7	endotoxin32	9.4	CASP1, ITGB1, IL18, LTA, IL1R1, LTF
8	proline32	9.3	IL1R1, CTTN, WAS, STX1A, ACTA1, ABL1
9	c2ceramide32	9.2	SRC, CASP3, MAPK14, MAPK8, IL1B, CHUK
10	helenalin32	9.1	MAPK8, CHUK, MAPK1, IL1B, MAPK9, SRC
11	n acetylcysteine32	9.0	MAPK10, IKBKB, F2, SRC, LTF, IL1R1
12	ceramide32	8.8	MAPK9, MAPK3, ABL1, MAPK14, CASP1, MAPK10
13	rottlerin32 42	9.6	ABL1, NFKBIA, MAPK1, RAC1, IL8, MAPK8
14	h2o232	8.6	VDAC1, MPO, CD79A, IL18, IL1RAPL2, MAPK8
15	gtp32	8.6	RAC1, VDAC1, WAS, CHUK, CDC42, MAPK3
16	geldanamycin32 9 9	10.4	IKBKG, MAPK1, SRC, MAPK10, MAPK14, MAPK3
17	sb 20358032 42	9.4	RAC1, CDC42, ITGB1, IL1R1, MAPK14, MAPK10
18	rantes32	8.3	CD44, CHUK, RAC1, IKBKB, IL1R1, IL1RAPL2
19	aspirin32 34 18	10.3	IL18, CD79A, CHUK, VASP, NFKBIB, OXA1L
20	12-o-tetradecanoylphorbol 13-acetate32	8.3	MAPK10, IKBKB, VCL, MAPK1, LTA, CD44
21	parthenolide32	8.3	NFKBIA, CASP3, IKBKB, MAPK14, MAPK10, MAPK8
22	atp32	8.1	RPA1, SLC4A1, STX1A, STX2, CRK, CTTN
23	cysteine32	8.0	VDAC1, RPA1, RAC1, SRC, CASP3, ITGB1
24	indomethacin32 9 9	10.0	SOD1, LTA, LTF, NFKBIA, SRC, IKBKB
25	herbimycin a32 42	8.8	MAPK14, MAPK3, MAPK8, IL8, MAPK10, MAPK1
26	fmlp32	7.8	IL1RAPL2, RAC1, CDC42, ITGB1, IL1B, IL8
27	lipid32	7.7	SOD1, PFN1, VCL, STX1A, ACTA1, ABL1
28	cyclosporin a32 42	8.7	LTA, VDAC1, LTF, ITGB1, NFKBIA, MAPK10
29	phosphoinositide32	7.6	ACTA1, ABL1, PFN1, MAPK9, VCL, RAC1
30	ly29400232	7.5	CASP3, NFKBIA, SRC, MAPK1, MAPK11, MAPK14
31	pdtc32	7.3	MAPK8, MAPK14, MAPK10, IKBKB, MAPK1, IL8
32	curcumin32	7.1	CASP3, CHUK, IL18, IL1B, IL8, MAPK8
33	arsenite32 18	8.0	CHUK, MAPK8, MAPK3, MAPK14, MAPK10, MAPK11
34	actinomycin d32	7.0	CASP1, MAPK1, CAMP, CASP3, IGF1, CD44
35	diphenyleneiodonium32	7.0	RAC1, MPO, IL1B, IL1R1, IL8, MAPK8
36	vegf32	6.9	MAPK3, IL1RAPL2, IL1R1, IL1B, ITGB1, ITGA5
37	wortmannin32 42	7.8	MAPK1, ATG5, CHUK, RAC1, VCL, WAS
38	cisplatin32 34 9 9	9.8	MAPK14, MAPK9, MAPK1, CASP3, CASP1, SRC
39	cytochalasin d32 42	7.8	WAS, VCL, RAC1, CDC42, CD44, IL1RAPL2
40	oxygen32 18	7.7	IL1RAPL2, MPO, CASP3, ABL1, LTA, NFKBIA
41	adp32 18	7.6	ABL1, RFC1, WAS, WASL, MAPK1, MAPK9
42	dexamethasone32 42 34 9 9	10.6	IL1R1, IKBKB, IL1B, IL18, CD44, IL8
43	egcg32	6.4	IL18, SOD1, NFKBIA, CASP3, MAPK1, MAPK14
44	cycloheximide32	6.3	VCL, ATG5, ITGB1, NFKBIA, CASP1, CASP3
45	pd 98,05932	6.2	MAPK8, IKBKB, IGF1, CASP3, CASP1, CAMP
46	nitric oxide32 9 18 9	9.1	MAPK1, MAPK14, MAPK3, IL8, IL1RAPL2, IL1R1
47	phosphatidylinositol32	5.7	ITGB1, RAC1, IL1R1, IL1RAPL2, MAPK9, MAPK1
48	retinoic acid32 42 18	7.7	IGF1, IL1R1, IL1RAPL2, MAPK8, MAPK3, LTA
49	tyrosine32	5.1	MAPK1, MAPK10, MAPK14, MAPK3, MAPK12, MAPK8
50	serine32	3.2	ROCK1, MAPK10, MAPK14, MAPK3, MAPK13, MAPK12

Cellular components related to shigellosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Arp2/3 protein complex	GO:005885	10.6	ARPC5, ARPC2, ARPC3, ARPC1B, ARPC4
2	IkappaB kinase complex	GO:008385	10.1	CHUK, IKBKB, IKBKG
3	actin cytoskeleton	GO:015629	10.0	ACTA1, WAS, WASF1, ABL1, PFN4, PFN3
4	lamellipodium	GO:030027	9.8	CTTN, ARPC3, RAC1, WASL, WASF2, WASF1
5	focal adhesion	GO:005925	9.4	MAPK1, MAPK3, ARPC2, ITGB1, ITGA5, VASP
6	cytoskeleton	GO:005856	8.9	ELMO1, ACTG1, ACTB, CTTN, SRC, CCIN
7	nucleoplasm	GO:005654	7.0	MAPK1, MAPK9, CASP3, TRIM27, RPA1, NFKB1
8	cytoplasm	GO:005737	6.0	NFKBIA, NFKB1, RPA1, NOD2, NOD1, CRK
9	cytosol	GO:005829	3.7	ROCK2, ROCK1, SOD1, HIF3A, ELMO1, ACTG1

Biological processes related to shigellosis according to GeneDecks:

(show top 50)    (show all 52)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of actin filament polymerization	GO:030833	10.8	ARPC5, ARPC5L, ARPC1A, ARPC3, ARPC1B
2	positive regulation of interleukin-6 production	GO:032755	10.5	RIPK2, NOD2, NOD1, MAPK13, IL1B
3	actin filament polymerization	GO:030041	10.4	WAS, WASF1, RAC1, ARPC4
4	positive regulation of JNK cascade	GO:046330	10.3	RIPK2, NOD2, NOD1, IL1B, CDC42
5	nucleotide-binding oligomerization domain containing 2 signaling pathway	GO:070431	10.3	RIPK2, NFKBIA, NOD2, RELA
6	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	10.3	RIPK2, NOD2, NOD1, CASP1, IKBKG, IKBKB
7	positive regulation of interferon-gamma production	GO:032729	10.3	IL18, IL1B, LTA, RIPK2
8	nucleotide-binding oligomerization domain containing signaling pathway	GO:070423	10.3	RIPK2, NOD2, NOD1, IKBKG, IKBKB, CHUK
9	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.1	RIPK2, NOD2, NOD1, CASP1, IKBKG, IKBKB
10	response to interleukin-1	GO:070555	10.0	RELA, IL1R1, SRC, RIPK2
11	positive regulation of type I interferon production	GO:032481	9.9	NFKBIB, NFKBIA, NFKB1, IKBKG, IKBKB, CHUK
12	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.9	CD44, IL1B, MAPK3, NOD1, NOD2, RIPK2
13	heart contraction	GO:060047	9.9	SOD1, CDC42, ATG5
14	T cell receptor signaling pathway	GO:050852	9.9	RIPK2, NFKBIA, NFKB1, IKBKG, IKBKB, CHUK
15	actin cytoskeleton organization	GO:030036	9.9	PFN4, RHOG, ABL1, ELMO1, ROCK1, ROCK2
16	positive regulation of muscle cell differentiation	GO:051149	9.9	ABL1, MAPK11, MAPK14, MAPK12, CDC42
17	JNK cascade	GO:007254	9.8	RIPK2, NOD2, NOD1, CRKL, IKBKG, MAPK9
18	muscle cell differentiation	GO:042692	9.8	ABL1, MAPK11, MAPK14, MAPK12, CDC42
19	MAPK cascade	GO:000165	9.8	MAPK1, MAPK3, MAPK13, MAPK12, IL1B, IL18
20	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.7	NFKB1, NFKBIA, NFKBIB, RIPK2, NOD2, NOD1
21	cellular response to mechanical stimulus	GO:071260	9.7	NFKB1, CASP1, MAPK3, MAPK8, IL1B, IL18
22	response to muramyl dipeptide	GO:032495	9.7	MAPK14, NOD2, NFKBIA
23	regulation of cell adhesion	GO:030155	9.7	ROCK2, ROCK1, ABL1, IL8, IL18
24	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	RIPK2, NFKBIA, MAPK14, MAPK3, IL1B, IL18
25	inflammatory response	GO:006954	9.3	RIPK2, NFKB1, NOD1, IKBKG, IKBKB, IL8
26	peptidyl-serine phosphorylation	GO:018105	9.2	MAPK1, MAPK14, MAPK13, MAPK12, MAPK8
27	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	8.9	MAPK9, MAPK1, MAPK11, MAPK10, MAPK14, MAPK3
28	virus-host interaction	GO:019048	8.9	NFKBIA, NLRX1, SRC, IKBKG, MAPK1, MAPK3
29	anti-apoptosis	GO:006916	8.8	RIPK2, SOD1, NFKBIA, NFKB1, IGF1, IKBKB
30	cellular component movement	GO:006928	8.8	ELMO1, WASF1, WASL, VCL, ACTG1, ACTB
31	Ras protein signal transduction	GO:007265	8.8	CRKL, SRC, IGF1, MAPK1, MAPK11, MAPK14
32	response to stress	GO:006950	8.8	MAPK9, MAPK1, MAPK11, MAPK14, MAPK13, MAPK8
33	stress-activated MAPK cascade	GO:051403	8.7	RIPK2, NOD2, NOD1, IKBKG, MAPK9, MAPK1
34	activation of MAPK activity	GO:000187	8.5	RIPK2, SOD1, NOD2, NOD1, IKBKG, MAPK1
35	axon guidance	GO:007411	8.3	RHOG, ABL1, ACTB, ACTG1, ST8SIA2, ROCK1
36	MyD88-independent toll-like receptor signaling pathway	GO:002756	7.9	NFKBIB, MAPK8, CHUK, RELA, MAPK3, MAPK14
37	TRIF-dependent toll-like receptor signaling pathway	GO:035666	7.9	RIPK2, NFKBIB, NFKBIA, NFKB1, NOD2, NOD1
38	toll-like receptor 3 signaling pathway	GO:034138	7.9	IKBKB, MAPK9, MAPK1, MAPK11, MAPK10, MAPK14
39	toll-like receptor 4 signaling pathway	GO:034142	7.8	RIPK2, NFKBIB, NFKBIA, NFKB1, NOD2, NOD1
40	toll-like receptor 2 signaling pathway	GO:034134	7.8	NOD2, NOD1, IKBKG, IKBKB, MAPK9, MAPK1
41	MyD88-dependent toll-like receptor signaling pathway	GO:002755	7.8	MAPK11, MAPK10, MAPK14, MAPK3, MAPK8, IRAK4
42	toll-like receptor signaling pathway	GO:002224	7.8	NOD1, IKBKG, IKBKB, MAPK9, MAPK1, MAPK11
43	toll-like receptor 1 signaling pathway	GO:034130	7.8	MAPK11, MAPK10, MAPK14, MAPK3, MAPK8, IRAK4
44	Toll signaling pathway	GO:008063	7.8	RIPK2, NFKBIB, NFKBIA, NFKB1, NOD2, RELA
45	signal transduction	GO:007165	7.7	DOCK1, SRC, NOD1, NFKBIB, LTA, STX2
46	platelet activation	GO:030168	7.4	SOD1, RHOG, PFN1, CRK, SRC, F2
47	innate immune response	GO:045087	7.3	MAPK11, MAPK10, MAPK14, MAPK3, MAPK8, IL1RAPL2
48	nerve growth factor receptor signaling pathway	GO:048011	7.3	IKBKB, CASP3, SRC, CRK, NFKB1, NFKBIA
49	apoptotic process	GO:006915	6.9	DOCK1, NOD1, NFKB1, NFKBIA, ABL1, ELMO1
50	blood coagulation	GO:007596	6.3	DOCK1, SRC, CRK, PFN1, RHOG, ABL1

Molecular functions related to shigellosis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	CARD domain binding	GO:050700	10.3	NOD1, NOD2, RIPK2
2	structural constituent of cytoskeleton	GO:005200	10.2	ACTG1, ACTB, ACTA1, CCIN, ARPC5, ARPC2
3	actin binding	GO:003779	9.9	ARPC1A, ARPC2, ARPC5L, ARPC5, DIAPH1, PFN1
4	JUN kinase activity	GO:004705	9.6	MAPK9, MAPK10, MAPK8
5	MAP kinase activity	GO:004707	9.2	MAPK1, MAPK11, MAPK14, MAPK3, MAPK13, MAPK12
6	protein serine/threonine kinase activity	GO:004674	8.6	IKBKB, ROCK1, ROCK2, RIPK2, MAPK1, MAPK11
7	ATP binding	GO:005524	6.8	SRC, NOD1, NOD2, NLRX1, ABL1, ACTA1
8	protein binding	GO:005515	0.6	SRC, LTF, ABL1, ACTA1, ACTB, ACTG1