MCID: SHG001
MIFTS: 52

Shigellosis malady

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Shigellosis

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 2CDC, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 29ICD10 via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Shigellosis:

Name: Shigellosis 11 46 13 52 48 2
Dysentery, Bacillary 37 66
Shigella Flexneri Infectious Disease 11
Shigella Sonnei Infectious Disease 11
 
Shigella Boydii Infectious Disease 11
Shigella Gastroenteritis 11
Bacillary Dysentery 11
Shigella Infections 66

Characteristics:

Orphanet epidemiological data:

52
shigellosis:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:12385
MeSH37 D004405
Orphanet52 ORPHA810
ICD10 via Orphanet29 A03.0, A03.1, A03.2 A03.3, A03.8, A03.9, more
UMLS via Orphanet67 C0013371

Summaries for Shigellosis

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Disease Ontology:11 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.

MalaCards based summary: Shigellosis, also known as dysentery, bacillary, is related to cervical incompetence and maligant granulosa cell tumor of ovary. An important gene associated with Shigellosis is CD79A (CD79a Molecule), and among its related pathways are Adherens junction and Signaling events mediated by VEGFR1 and VEGFR2. The drugs loperamide and loperamide hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and t cells, and related mouse phenotypes are cellular and immune system.

Wikipedia:69 Shigellosis, also known as bacillary dysentery or Marlow syndrome, in its most severe manifestation, is... more...

Related Diseases for Shigellosis

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Diseases related to Shigellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1cervical incompetence10.4CDC42, CXCL8
2maligant granulosa cell tumor of ovary10.4CXCL8, LTA
3lymphangiectasia, intestinal10.3CXCL8, LTF
4focal embolic glomerulonephritis10.3CD79A, CXCL8
53-alpha hydroxyacyl-coa dehydrogenase deficiency10.3CXCL8, LTF
6diversion colitis10.2CDC42, LTF
7fallopian tube disease10.2CD79A, CXCL8
8addison's disease10.2CD79A, CXCL8
9hypervitaminosis d10.1CD79A, TTR
10cholera10.1
11dysentery10.1
12hematocele of tunica vaginalis testis10.1CD79A, TTR
13plague10.1CD79A, TTR
14flinders island spotted fever10.1CASP1, CXCL8
15neurofibroma of the esophagus10.1CXCL8, LTA
16diarrhea10.1
17encephalopathy10.1
18boutonneuse fever10.0CD79A, LTF
19sialadenitis10.0CD79A, LTF
20bone lymphoma10.0CD79A, TTR
21hemolytic-uremic syndrome10.0
22hemorrhagic fever with renal syndrome9.9CD79A, CXCL8, NOD1
23hepatitis9.9
24typhoid fever9.9
25extrahepatic cholestasis9.9CD79A, CXCL8, TTR
26ankylosis9.9CD79A, CXCL8
27bacteremia9.8
28acute diarrhea9.8
29listeriosis9.8
30hepatitis a9.8
31campylobacteriosis9.8
32toxic encephalopathy9.8
33pneumonia9.8
34appendicitis9.8
35measles9.8
36asymptomatic dengue9.7CD79A, LTF
37insulin-like growth factor i9.7
38osmotic diarrhea9.7
39brugada syndrome9.7
40taeniasis9.7
41colitis9.7
42cysticercosis9.7
43brucellosis9.7
44q fever9.7
45henoch-schoenlein purpura9.7
46chlamydia9.7
47megacolon9.7
48chagas disease9.7
49marasmus9.7
50ancylostomiasis9.7

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Symptoms for Shigellosis

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Drugs & Therapeutics for Shigellosis

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Drugs for Shigellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RifaximinPhase 39780621-81-46436173
Synonyms:
(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate
4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV
4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin
80621-81-4
88747-56-2
AC-19112
BRN 3584528
Bio-0556
C43H51N3O11
CHEMBL1617
D02554
DB01220
Fatroximin
Flonorm
L 105
L 105 (Ansamacrolide antibiotic)
L 105SV
LS-178059
LS-64147
Lormyx
Lumenax
MLS000759430
Normix
RedActiv
 
Rifacol
Rifamixin
Rifamycin L 105
Rifamycin L 105SV
Rifaxidin
Rifaximin
Rifaximin (USAN/INN)
Rifaximin [USAN:INN]
Rifaximina
Rifaximina [Spanish]
Rifaximine
Rifaximine [French]
Rifaximinum
Rifaximinum [Latin]
Rifaximinun
Rifaxin
Ritacol
S1790_Selleck
SMR000466324
Spiraxin
UNII-L36O5T016N
Xifaxan
Xifaxan, Rifacol, Fatroximin, Rifaximin
Xifaxsan
Xifaxsan (TN)
alpha-0817185
2rifamycin SVPhase 392
3
ZincPhase 321547440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+
4
Histamine PhosphatePhase 2100851-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
5
histaminePhase 2100975614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
6
butyric acidPhase 2350107-92-6264
Synonyms:
1-Butanoate
1-Butanoic acid
1-Butyrate
1-Butyric acid
1-Propanecarboxylate
1-Propanecarboxylic acid
Butanate
Butanic acid
Butanoate
Butanoic acid
Buttersaeure
Butyrate
 
Butyric acid
Ethylacetate
Ethylacetic acid
Honey robber
Kyselina maselna
N-Butanoate
N-Butanoic acid
N-Butyrate
N-Butyric acid
Propanecarboxylate
Propanecarboxylic acid
Propylformate
Propylformic acid
7
Aluminum hydroxidePhase 119421645-51-2
Synonyms:
Al(OH)3
Aluminium hydroxide
Aluminium hydroxide gel, dried
 
Aluminium hydroxide, dried
Aluminum hydroxide gel, dried
Aluminum hydroxide, dried
Dried aluminium hydroxide
Dried aluminum hydroxide gel
8
Formaldehyde8350-00-0712
Synonyms:
Aldeide formica
Fannoform
Formaldehyde
Formalin
Formalina
Formaline
Formalith
Formic aldehyde
Formol
 
Methaldehyde
Methanal
Methyl aldehyde
Methylene glycol
Methylene oxide
Oxomethane
Oxomethylene
Oxymethylene
Paraform
Paraformaldehyde
9Ether55

Interventional clinical trials:

(show all 34)
idNameStatusNCT IDPhase
1Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in IsraelCompletedNCT00368316Phase 3
2Zinc Supplementation in Shigella PatientsCompletedNCT00321126Phase 3
3Rifaximin for Prevention of Travellers' DiarrheaCompletedNCT00742469Phase 3
4Therapeutic Induction of Endogenous AntibioticsCompletedNCT00800930Phase 2
5Healthy Adult Volunteer Study for Two Doses of a Shigella VaccineCompletedNCT00210288Phase 2
6Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine CandidateCompletedNCT01080716Phase 1, Phase 2
7Shigella Flexneri 2a Invaplex 50 Vaccine Dose Finding and Assessment of ProtectionCompletedNCT00485134Phase 1, Phase 2
8A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan AdultsRecruitingNCT02676895Phase 2
9Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2aActive, not recruitingNCT02646371Phase 2
10Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIbTerminatedNCT00866242Phase 2
11Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIaTerminatedNCT00866476Phase 2
12Shigella Sonnel O-SPC/rBRU Conjugate VaccineCompletedNCT01369927Phase 1
13Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMPCompletedNCT01531530Phase 1
14Safety Study of Inactivated Shigella Whole Cell Vaccine in AdultsCompletedNCT01509846Phase 1
15A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults.CompletedNCT02017899Phase 1
16Evaluate a New Shigella Sonnei Vaccine Administered Either by Intradermal, Intranasal or Intramuscular Route in Healthy AdultsCompletedNCT02034500Phase 1
17Safety and Immunogenicity of Two Live, Attenuated Oral Shigella Sonnei Vaccines: WRSs2 and WRSs3CompletedNCT01336699Phase 1
18Safety and Reactogenicity of Bioconjugate Vaccine to Prevent ShigellaCompletedNCT01069471Phase 1
19Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2aCompletedNCT02388009Phase 1
20Invaplex 50 Vaccine Dose-RangingCompletedNCT00082069Phase 1
21Effect of 15g Daily Consumption of NUTRIOSE on Healthy Volunteers Microbiota.CompletedNCT01897649Phase 1
22Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR) Administered Intranasally to Healthy, Adult VolunteersRecruitingNCT02445963Phase 1
23Phase 1 Study of dmLT ID Vaccination in Healthy AdultsRecruitingNCT02531685Phase 1
24Shigella Sonnei 53G ChallengeNot yet recruitingNCT02816346Phase 1
25SF2a-TT15 Conjugate Vaccine in Healthy Adult VolunteersNot yet recruitingNCT02797236Phase 1
26Shigella Sonnei OSPC-rDT Conjugate VaccineWithdrawnNCT01399424Phase 1
27The Long Term Clinical Course of Postinfectious Irritable Bowel Syndrome After Shigellosis; A 10 Year Follow up StudyCompletedNCT02516683
28Safety Study of Live Shigella Vaccine in Bangladeshi Adults and ChildrenCompletedNCT01813071
29Evaluation of a Diagnostic Enteric Card for Management of DiarrheaCompletedNCT00736567
30COmparison of MicroBiota AccordIng to Age in Crohn's Disease (COMeBACk)RecruitingNCT02839317
31Experimental Phage Therapy of Bacterial InfectionsRecruitingNCT00945087
32A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty HospitalsActive, not recruitingNCT01612572
33Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive DisordersActive, not recruitingNCT02105714
34Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli InfectionsNot yet recruitingNCT01638039

Search NIH Clinical Center for Shigellosis

Inferred drug relations via UMLS66/NDF-RT44:


Cochrane evidence based reviews: dysentery, bacillary

Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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MalaCards organs/tissues related to Shigellosis:

34
Colon, T cells, Breast, Neutrophil, Appendix, Kidney, Testes

FMA organs/tissues related to Shigellosis:

17
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

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MGI Mouse Phenotypes related to Shigellosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053846.5BTRC, CASP1, CD79A, CTTN, IRAK4, LTF
2MP:00053876.2BTRC, CASP1, CD79A, CTTN, IRAK4, LTA
3MP:00053976.1BTRC, CASP1, CD79A, CTTN, IRAK4, LTA

Publications for Shigellosis

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Articles related to Shigellosis:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Shigellosis in men who have sex with men: an overlooked opportunity to counsel with pre-exposure prophylaxis for HIV. (26945593)
2016
2
Shigellosis in refugees, Austria, July to November 2015. (26676065)
2015
3
Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. (24680068)
2014
4
Cholera and shigellosis: different epidemiology but similar responses to climate variability. (25229494)
2014
5
Use of population-based surveillance to define the high incidence of shigellosis in an urban slum in Nairobi, Kenya. (23505506)
2013
6
Gastrointestinal and extra-intestinal manifestations of childhood shigellosis in a region where all four species of Shigella are endemic. (23691156)
2013
7
Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases. (22606962)
2012
8
How we didn't clean up until we washed our hands: shigellosis in an elementary and middle school in North Texas. (22189658)
2012
9
A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children. (21829747)
2011
10
Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh. (17554249)
2008
11
Comparison of cost-of-illness with willingness-to-pay estimates to avoid shigellosis: evidence from China. (18234703)
2008
12
Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the Peruvian Amazon. (18710884)
2008
13
Risk factors for shigellosis in Thailand. (16997593)
2006
14
Risk factors for mortality due to shigellosis: a case-control study among severely-malnourished children in Bangladesh. (16262023)
2005
15
Azithromycin as an alternative to nalidixic acid in the therapy of childhood shigellosis. (15071299)
2004
16
Laboratory-confirmed shigellosis in the United States, 1989-2002: epidemiologic trends and patterns. (15156473)
2004
17
Detection of Shigella by a PCR assay targeting the ipaH gene suggests increased prevalence of shigellosis in Nha Trang, Vietnam. (15131166)
2004
18
Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development. (15030306)
2003
19
Disease-dependent changes in T-cell populations in patients with shigellosis. (10843411)
2000
20
Shigellosis of childhood in northern Greece: epidemiological, clinical and laboratory data of hospitalized patients during the period 1971-96. (10826910)
2000
21
Shigellosis in a squirrel monkey: a clinical history. (10576630)
1999
22
Antimicrobial therapy for shigellosis: issues on antimicrobial resistance. (10211436)
1998
23
Epidemiology of shigellosis among children exposed to cases of Shigella dysentery: a multivariate assessment. (9129527)
1997
24
Prevalence of shigellosis in the U.S.: consistency with dose-response information. (8856376)
1996
25
Shigellosis: from molecular pathogenesis of infection to protective immunity and vaccine development. (9127893)
1996
26
Absorption of macronutrients from a calorie-dense diet in malnourished children during acute shigellosis. (8811519)
1996
27
Shigellosis in Thai children: experience from a rural hospital 1985-1993. (8629073)
1995
28
Epidemiological, clinical and microbiological features of shigellosis among hospitalized children in northern Israel. (7660077)
1995
29
Moose soup shigellosis in Alaska. (8048226)
1994
30
Short-course norfloxacin and trimethoprim-sulfamethoxazole treatment of shigellosis and salmonellosis in Egypt. (8074256)
1994
31
An outbreak of shigellosis in a slum colony of Delhi-1990. (8014439)
1993
32
Evaluation of an intervention program for the control of an outbreak of shigellosis among institutionalized persons. (8228351)
1993
33
Prevalence of shigellosis and other enteric pathogens in a zoologic collection of primates. (8407446)
1993
34
From the Centers for Disease Control. Shigellosis in child day care centers--Lexington-Fayette County, Kentucky, 1991. (1640601)
1992
35
Effects of a protein-rich diet during convalescence from shigellosis on catch-up growth, serum proteins, and insulin-like growth factor-I. (1287560)
1992
36
Natural immunity to shigellosis in two groups with different previous risks of exposure to Shigella is only partly expressed by serum antibodies to lipopolysaccharide. (1552217)
1992
37
Childhood shigellosis in Saudi Arabia. (1565538)
1992
38
Potentials of Shigella flexneri Y strain TSF21 as a candidate vaccine against shigellosis: safety, immunogenicity and protective efficacy in Bonnet monkeys. (1878259)
1991
39
Shigellosis in Kentucky, 1986 through 1989. (2068620)
1991
40
Epidemiologic aspects of shigellosis and other causes of dysentery in Thailand. (2047642)
1991
41
Prospective study of the association between serum antibodies to lipopolysaccharide O antigen and the attack rate of shigellosis. (1706731)
1991
42
Recurrent shigellosis complicating human immunodeficiency virus infection: failure of pre-existing antibodies to confer protection. (2642653)
1989
43
Shigellosis winter trends in Milwaukee. (2786286)
1989
44
Therapy for shigellosis. (2738789)
1989
45
An outbreak of shigellosis in central India: higher death rate in post-measles shigellosis. (2607100)
1989
46
A shigellosis outbreak traced to commercially distributed shredded lettuce. (3057879)
1988
47
Erythrocyte vacuolation in haemolytic anaemia during shigellosis. (2885569)
1987
48
The relation between production of cytotoxin and clinical features in shigellosis. (3519788)
1986
49
Incidence of shigellosis among paediatric diarrhoeal disorders (a bacteriological study). (6491334)
1984
50
Appendiceal perforation and shigellosis. (6364623)
1983

Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Pathways related to Shigellosis according to KEGG:

32
id Name KEGG Source Accession
1Shigellosishsa05131

Pathways related to Shigellosis according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathwaysScoreTop Affiliating Genes
19.6CDC42, SRC, VCL
2
Show member pathways
9.6CDC42, SRC, VCL
39.6CDC42, CTTN, SRC
49.6CDC42, CTTN, SRC
59.6CDC42, CTTN, SRC
69.5CRK, SRC, VCL
79.5CTTN, CXCL8, SRC
89.5CDC42, CRK, SRC
99.5CDC42, CRK, SRC
10
Show member pathways
9.5CDC42, CRK, SRC
119.5BTRC, SRC
129.5CRK, CXCL8, SRC
139.5CDC42, IRAK4, SRC
14
Show member pathways
9.4CDC42, PFN1, VCL
159.4CXCL8, IRAK4, LTA
16
Show member pathways
9.3CDC42, CTTN, SRC, VCL
179.3CDC42, CRK, SRC, VCL
18
Show member pathways
9.3CDC42, CRK, SRC, VCL
199.2CDC42, CRK, CTTN, SRC
20
Show member pathways
9.2CDC42, CRK, CXCL8, SRC
219.2CDC42, CTTN, PFN1, VCL
22
Show member pathways
9.2CDC42, CRK, IRAK4, SRC
23
Show member pathways
9.2CASP1, LTA, SRC, VCL
24
Show member pathways
9.1CASP1, CDC42, CXCL8, PFN1
259.1CASP1, CXCL8, IRAK4, NOD1
26
Show member pathways
9.0CDC42, CTTN, PFN1, SRC
279.0CDC42, CRK, CTTN, SRC, VCL
28
Show member pathways
8.7CDC42, CRK, PFN1, SRC, VCL
29
Show member pathways
8.7CDC42, CRK, PFN1, SRC, VCL
30
Show member pathways
8.7BTRC, CASP1, IRAK4, NOD1
31
Show member pathways
8.7CASP1, CXCL8, IRAK4, NOD1, SRC
32
Show member pathways
8.2CASP1, CDC42, CRK, CXCL8, LTA, SRC
33
Show member pathways
8.2CDC42, CXCL8, LTF, NOD1, SRC
347.0BTRC, CDC42, CRK, CTTN, CXCL8, NOD1
35
Show member pathways
6.0BTRC, CASP1, CD79A, CDC42, CRK, IRAK4

GO Terms for genes affiliated with Shigellosis

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Cellular components related to Shigellosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1focal adhesionGO:00059259.6CDC42, CTTN, PFN1, VCL
2cell-cell adherens junctionGO:00059139.5CTTN, PFN1, SRC, VCL
3cytosolGO:00058297.1BTRC, CASP1, CDC42, CRK, IRAK4, NOD1
4cytoplasmGO:00057375.5BTRC, CD79A, CDC42, CRK, CTTN, IRAK4

Biological processes related to Shigellosis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell-cell adhesionGO:009013610.4CDC42, VCL
2branching involved in mammary gland duct morphogenesisGO:00604449.8BTRC, SRC
3ephrin receptor signaling pathwayGO:00480139.7CDC42, CRK, SRC
4vascular endothelial growth factor receptor signaling pathwayGO:00480109.4CDC42, CRK, SRC
5Fc-gamma receptor signaling pathway involved in phagocytosisGO:00380969.2CDC42, CRK, SRC
6positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431238.9CASP1, IRAK4, LTF, NOD1
7signal transductionGO:00071657.9BTRC, CASP1, CXCL8, LTA, NOD1, SRC

Molecular functions related to Shigellosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activator activity involved in apoptotic processGO:000865610.3CASP1, NOD1
2protein phosphorylated amino acid bindingGO:004530910.2BTRC, CRK
3cadherin binding involved in cell-cell adhesionGO:00986419.5CTTN, PFN1, SRC, VCL
4protein bindingGO:00055154.5BTRC, CASP1, CD79A, CDC42, CRK, CTTN

Sources for Shigellosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet