MCID: SHG001
MIFTS: 65

Shigellosis malady

Rare diseases, Infectious diseases, Gastrointestinal diseases categories
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Summaries for Shigellosis

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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.

MalaCards based summary: Shigellosis, also known as shigella gastroenteritis, is related to influenza and arthritis. An important gene associated with Shigellosis is CASP1 (caspase 1, apoptosis-related cysteine peptidase), and among its related pathways are TRAF Pathway and Legionellosis. The drugs loperamide and bismuth subcarbonate and the compounds acetyl-tyr-val-ala-asp-cho and tlck have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, colon and breast, and related mouse phenotypes are immune system and cardiovascular system.

Wikipedia:65 Shigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is... more...

Aliases & Classifications for Shigellosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Shigellosis, Aliases & Descriptions:

Name: Shigellosis 8 42 10 44 48
Shigella Gastroenteritis 8 62
Shigella Flexneri Infectious Disease 8
Shigella Sonnei Infectious Disease 8
 
Shigella Boydii Infectious Disease 8
Dysentery, Bacillary 62
Bacillary Dysentery 8
Shigella Infections 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
shigellosis:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:12385
ICD9CM27 004, 004.9
MeSH34 D004405
ICD10 via Orphanet26 A03.0, A03.1, A03.2 A03.3, A03.8, A03.9, more
UMLS via Orphanet63 C0013371

Related Diseases for Shigellosis

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Diseases related to Shigellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1influenza30.2CASP1, LTF, LTA
2arthritis30.2IL1R1, IL1B, CASP1, LTA, LTF
3septic shock30.2LTA, CASP1, IL1B, LTF, IL1R1
4colitis30.1LTF, IL1B, IL1R1
5sepsis30.0LTF, IL1R1, CASP1, LTA, IL1B
6blindness10.5
7periodontitis10.4IL1B
8cholera10.4
9paratyphoid fever10.4
10dysentery10.4
11gastroenteritis10.4
12periodontal disease10.4LTF
13acute graft versus host disease10.3IL1R1, LTA
14juvenile rheumatoid arthritis10.3IL1R1, LTA
15diarrhea10.3
16myocardial infarction10.3VCL, CASP1
17toxic shock syndrome10.3IL1B, LTA
18adult respiratory distress syndrome10.3IL1B, LTA
19irritable bowel syndrome10.2
20mastitis10.2LTF, IL1B
21hemolytic-uremic syndrome10.2
22gingivitis10.2IL1B, LTF
23otitis media10.2IL1B, LTF
24familial cold autoinflammatory syndrome10.2CASP1, IL1B, IL1R1
25chronic infantile neurological cutaneous articular syndrome10.2CASP1, IL1B, IL1R1
26muckle-wells syndrome10.2IL1R1, IL1B, CASP1
27uveitis10.2LTA, IL1R1
28reactive arthritis10.2
29hepatitis10.2
30typhoid fever10.2
31cerebral malaria10.2VCL, IL1B, IL1R1
32type 1 diabetes mellitus10.2LTA, IL1B, IL1R1
33bacterial vaginosis10.2LTF, IL1B, IL1R1
34chorioamnionitis10.2IL1R1, IL1B, LTF
35pancreatitis10.2LTF, IL1B, CASP1
36campylobacteriosis10.1
37hepatitis a10.1
38acute diarrhea10.1
39appendicitis10.1
40measles10.1
41listeriosis10.1
42toxic encephalopathy10.1
43pneumonia10.1
44bacteremia10.1
45graft versus host disease10.1LTA, IL1R1
46systemic lupus erythematosus10.1IL1R1, LTA, LTF
47familial mediterranean fever10.1IL1B, CARD17, CASP1
48multiple sclerosis10.1IL1R1, CASP1, LTA, IL1B
49monocytic leukemia10.1IL1B, LTF, CASP1, IL1R1
50stomach cancer10.0CASP1, IL1B, IL1R1, LTA

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Symptoms for Shigellosis

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Drugs & Therapeutics for Shigellosis

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Genetic Tests for Shigellosis

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Anatomical Context for Shigellosis

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MalaCards organs/tissues related to Shigellosis:

32
Colon, Breast, T cells, Brain, Kidney, Testes, Appendix, Neutrophil

FMA organs/tissues related to Shigellosis:

14
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

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MGI Mouse Phenotypes related to Shigellosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.5LTF, LTA, RHOG, CASP1, IL1B, IL1R1
2MP:00053858.2VCL, VASP, IL1R1, IL1B, CASP1, LTA
3MP:00053978.0LTF, VASP, IL1R1, IL1B, CASP1, RHOG
4MP:00036318.0VCL, VASP, IL1R1, IL1B, CASP1, RHOG

Publications for Shigellosis

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Articles related to Shigellosis:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. (24680068)
2014
2
Investigation of key interventions for shigellosis outbreak control in China. (24736407)
2014
3
Use of population-based surveillance to define the high incidence of shigellosis in an urban slum in Nairobi, Kenya. (23505506)
2013
4
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. (23775017)
2013
5
Systemic shigellosis in South Africa. (22474223)
2012
6
Characterization of Shigella sonnei in Malaysia, an increasingly prevalent etiologic agent of local shigellosis cases. (22606962)
2012
7
A 9-year study of shigellosis in Northeast Malaysia: Antimicrobial susceptibility and shifting species dominance. (21654922)
2011
8
Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia. (21029529)
2010
9
Risk factors for sporadic shigellosis, FoodNet 2005. (20113209)
2010
10
Zinc supplementation in the management of shigellosis in malnourished children in Bangladesh. (17554249)
2008
11
Comparison of cost-of-illness with willingness-to-pay estimates to avoid shigellosis: evidence from China. (18234703)
2008
12
Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the Peruvian Amazon. (18710884)
2008
13
High prevalence of CTX-M-15 extended-spectrum beta-lactamase among contacts of patients with shigellosis due to Shigella flexneri carrying CTX-M-15. (17646198)
2007
14
Risk factors for shigellosis in Thailand. (16997593)
2006
15
Azithromycin as an alternative to nalidixic acid in the therapy of childhood shigellosis. (15071299)
2004
16
Acceptability and accessibility of a Shigellosis vaccine in Nha Trang city of Viet Nam. (15473518)
2004
17
Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development. (15030306)
2003
18
A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase. (11178905)
2001
19
Disease-dependent changes in T-cell populations in patients with shigellosis. (10843411)
2000
20
Pathogenesis of shigellosis: from molecular and cellular biology of epithelial cell invasion to tissue inflammation and vaccine development. (10211438)
1998
21
Double-blind, randomized clinical trial for safety and efficacy of norfloxacin for shigellosis in children. (9099325)
1997
22
Pathogenesis and immune responses in shigellosis. (8993387)
1996
23
Prevalence of shigellosis in the U.S.: consistency with dose-response information. (8856376)
1996
24
Shigellosis: from molecular pathogenesis of infection to protective immunity and vaccine development. (9127893)
1996
25
Shigellosis in Thai children: experience from a rural hospital 1985-1993. (8629073)
1995
26
Epidemiological, clinical and microbiological features of shigellosis among hospitalized children in northern Israel. (7660077)
1995
27
Short-term pefloxacin therapy in Madagascan children with shigellosis due to multiresistant organisms. (7888566)
1994
28
Moose soup shigellosis in Alaska. (8048226)
1994
29
An outbreak of shigellosis in a slum colony of Delhi-1990. (8014439)
1993
30
Evaluation of an intervention program for the control of an outbreak of shigellosis among institutionalized persons. (8228351)
1993
31
Shigellosis complicated by perforated appendix. (8483634)
1993
32
Shigellosis in Thai children: epidemiologic, clinical and laboratory features. (1565537)
1992
33
From the Centers for Disease Control. Shigellosis in child day care centers--Lexington-Fayette County, Kentucky, 1991. (1640601)
1992
34
Shigellosis-associated encephalopathy. (1408493)
1992
35
Efficacy of norfloxacin for shigellosis: a double-blind randomised clinical trial. (1430968)
1992
36
Evaluation of indigenous plants in the treatment of acute shigellosis. (1816661)
1991
37
Potentials of Shigella flexneri Y strain TSF21 as a candidate vaccine against shigellosis: safety, immunogenicity and protective efficacy in Bonnet monkeys. (1878259)
1991
38
An outbreak of shigellosis aboard a cruise ship caused by a multiple-antibiotic-resistant strain of Shigella flexneri. (1652203)
1991
39
Shigellosis. (1861289)
1991
40
The use of hygiene, cohorting, and antimicrobial therapy to control an outbreak of shigellosis. (2405639)
1990
41
Single-dose ciprofloxacin for shigellosis. (1971401)
1990
42
Death in shigellosis: incidence and risk factors in hospitalized patients. (2313128)
1990
43
Recurrent shigellosis complicating human immunodeficiency virus infection: failure of pre-existing antibodies to confer protection. (2642653)
1989
44
Plasmid profile as a useful marker of a Shigella dysenteriae type 1 strain causing an epidemic of shigellosis. (3077946)
1988
45
A shigellosis outbreak traced to commercially distributed shredded lettuce. (3057879)
1988
46
Leads from the MMWR. Multiply resistant shigellosis in a day-care center--Texas. (3540326)
1987
47
Shigellosis in children. (3428993)
1987
48
Comparative efficacies of single intravenous doses of ceftriaxone and ampicillin for shigellosis in a placebo-controlled trial. (3518625)
1986
49
The relation between production of cytotoxin and clinical features in shigellosis. (3519788)
1986
50
Incidence of shigellosis among paediatric diarrhoeal disorders (a bacteriological study). (6491334)
1984

Variations for Shigellosis

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Expression for genes affiliated with Shigellosis

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Expression patterns in normal tissues for genes affiliated with Shigellosis

Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

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Pathways related to Shigellosis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9LTA, CASP1
29.8CASP1, IL1B
39.8IL1B, CASP1
49.8LTA, IL1B
5
Show member pathways
IL27-mediated signaling events37
9.8LTA, IL1B
6
Show member pathways
Serotonin Transporter Activity37
9.8IL1B, IL1R1
79.7VASP, VCL
8
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.6IL1R1, CASP1, LTA
9
Show member pathways
9.6VCL, CASP1, LTA
10
Show member pathways
9.6LTA, CASP1, IL1B
11
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.5CASP1, IL1B, IL1R1
12
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
9.5IL1R1, IL1B, CASP1
13
Show member pathways
MAPK signaling pathway37
9.5IL1R1, IL1B, CASP1
14
Show member pathways
9.5LTA, IL1B, IL1R1
15
Show member pathways
9.5LTA, IL1B, IL1R1
169.5IL1R1, IL1B, LTA
17
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5IL1R1, IL1B, LTA
189.5IL1B, IL1R1, VCL
19
Show member pathways
9.3IL1R1, IL1B, CASP1, LTA
20
Show member pathways
9.3IL1R1, IL1B, CASP1, LTA
219.2ARPC5L, RHOG, VCL
22
Show member pathways
9.0IL1B, CARD17, CASP1
23
Show member pathways
8.9LTA, CASP1, IL1B, IL1R1, VCL
24
Show member pathways
8.9PFN3, PFN4, VASP
25
Show member pathways
8.7IL1R1, IL1B, CARD17, CASP1
26
Show member pathways
8.7CASP1, CARD17, IL1B, IL1R1
27
Show member pathways
8.5ARPC5L, VCL, PFN4, PFN3
28
Show member pathways
7.4ARPC5L, PFN3, PFN4, VCL, IL1B, CASP1

Compounds for genes affiliated with Shigellosis

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Compounds related to Shigellosis according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1acetyl-tyr-val-ala-asp-cho4410.2IL1B, CASP1
2tlck4410.1CASP1, IL1B
3ag-1264410.1CASP1, IL1B
4muramyl dipeptide44 2811.1CASP1, IL1B
5monosodium urate4410.1IL1R1, IL1B
6toxin-14410.0LTA, IL1B
7cytochalasin4410.0VCL, LTF
8rabeprazole44 50 24 1113.0IL1B, LTF
9git 276110.0IL1R1, IL1B
10anakinra44 1111.0IL1R1, CASP1, IL1B
11as 10144 6111.0IL1R1, CASP1, IL1B
12cuprophan4410.0IL1R1, CASP1, IL1B
134-ipp6110.0IL1R1, IL1B
14lipoteichoic acid449.9IL1R1, IL1B, LTA
15diphenyleneiodonium449.9IL1R1, IL1B, CASP1
16etanercept44 50 1111.9IL1R1, IL1B, LTA
17minocycline44 1110.9LTF, IL1B, CASP1
18gold sodium thiomalate449.9IL1B, IL1R1
19peptidoglycan44 2810.9CASP1, IL1R1, IL1B
20il 10449.9IL1R1, LTA, IL1B
21tenidap44 2810.9IL1B, LTF, IL1R1
22infliximab44 50 1111.9IL1R1, IL1B, LTA
23ivig449.9LTA, IL1B, IL1R1
24ibuprofen44 28 50 24 1113.8LTF, IL1R1, IL1B
25leukotriene b444 61 2411.8IL1R1, IL1B, LTF
26hydrocortisone44 2 61 1112.7IL1B, IL1R1, LTF
27neopterin449.6LTF, LTA, IL1B, IL1R1
28cyclosporin a44 28 6111.6IL1R1, LTF, LTA, CASP1
29mannose449.6LTF, LTA, VCL
30hyaluronic acid44 2410.6IL1B, LTA, LTF, IL1R1
31n acetylcysteine449.6IL1B, IL1R1, CASP1, LTF
32phosphatidylserine44 28 1111.5VCL, CASP1, LTF
33pirfenidone44 6110.5IL1R1, IL1B
34aspirin44 50 28 2412.5VASP, IL1R1, IL1B, CASP1
35fmlp449.5IL1B, LTA, LTF
36fibrinogen449.4VASP, IL1R1, LTF, VCL
37pentoxifylline44 1110.4CASP1, IL1R1, IL1B, LTA, LTF
38endotoxin449.4LTA, IL1B, CASP1, IL1R1, LTF
39h2o2449.4IL1R1, LTF, LTA, VCL, CASP1
40actinomycin d449.3LTF, LTA, CASP1, IL1B, IL1R1
41cycloheximide449.3IL1R1, IL1B, CASP1, LTA, VCL
42pge2449.3IL1R1, IL1B, CASP1, LTA, LTF
43dexamethasone44 50 28 1112.3LTF, LTA, CASP1, IL1B, IL1R1
44retinoic acid44 2410.2LTA, CASP1, IL1B, LTF, IL1R1
45prostacyclin449.2LTF, IL1B, VASP
46threonine449.2VASP, CASP1, LTA, VCL, IL1R1
47indomethacin44 28 61 1112.2LTF, LTA, IL1B, IL1R1, VASP
48vegf449.0LTA, CASP1, LTF, IL1B, IL1R1, VCL
49nitric oxide44 24 1110.9IL1B, CASP1, VCL, VASP, IL1R1, LTA
50serine448.8VCL, LTA, LTF, CASP1, IL1R1, VASP

GO Terms for genes affiliated with Shigellosis

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Cellular components related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6VCL, IL1R1, IL1B, CASP1, LTF
2extracellular vesicular exosomeGO:0700628.4ARPC5L, LTF, RHOG, VASP, VCL
3cytoskeletonGO:0058568.4ARPC5L, VCL, PFN4, PFN3

Biological processes related to Shigellosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.0CASP1, IL1B
2regulation of inflammatory responseGO:0507279.9CASP1, IL1R1
3response to ATPGO:0331989.9CASP1, IL1B
4cellular response to organic substanceGO:0713109.7CASP1, IL1B
5positive regulation of interferon-gamma productionGO:0327299.5LTA, IL1B
6positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.5IL1B, CASP1, LTF
7actin cytoskeleton organizationGO:0300369.0RHOG, PFN4, PFN3

Molecular functions related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:0037798.0ARPC5L, VASP, VCL, PFN4, PFN3

Products for genes affiliated with Shigellosis

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Sources for Shigellosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet