MCID: SHG001
MIFTS: 57

Shigellosis malady

Infectious, Gastrointestinal categories

Summaries for Shigellosis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
CDC:3 Shigellosis is an infectious disease caused by a group of bacteria called Shigella. Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. The diarrhea is often bloody. Shigellosis usually resolves in 5 to 7 days. Persons with shigellosis in the United States rarely require hospitalization. A severe infection with high fever may be associated with seizures in children less than 2 years old. Some persons who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others.

MalaCards: Shigellosis, also known as shigella flexneri infectious disease, is related to septic shock and sepsis. An important gene associated with Shigellosis is VCL (vinculin), and among its related pathways are PAK Pathway and Apoptosis Modulation and Signaling. The drugs loperamide and loperamide hydrochloride and the compounds pentoxifylline and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include epithelium of colon, brain and kidney.

Disease Ontology:8 A primary bacterial infectious disease that results in infection located in epithelium of colon, has material basis in shigella boydii, has material basis in shigella dysenteriae, has material basis in shigella flexneri, or has material basis in shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. the bacteria are transmitted by ingestion of food and water contaminated with feces.

Wikipedia:64 Shigellosis, also known as bacillary dysentery or Marlow Syndrome, in its most severe manifestation, is... more...

Aliases & Classifications for Shigellosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
shigellosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

shigellosis 8 43 10 45 49
shigella flexneri infectious disease 8
shigella boydii infectious disease 8
shigella sonnei infectious disease 8
shigella gastroenteritis 8
dysentery, bacillary 61
shigella infections 61
bacillary dysentery 8


External Ids:

Disease Ontology8 DOID:12385
MeSH35 D004405
ICD9CM27 004.9, 004
ICD10 via Orphanet26 A03
SNOMED-CT via Orphanet58 36188001

Related Diseases for Shigellosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Shigellosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1septic shock30.2CASP1, LTA, LTF, IL1R1, IL1B
2sepsis30.1IL1B, IL1R1, LTF, LTA, CASP1
3paratyphoid fever10.4
4cholera10.3
5irritable bowel syndrome10.2
6hemolytic-uremic syndrome10.2
7reactive arthritis10.2
8arthritis10.2
9typhoid fever10.1
10acute diarrhea10.1
11campylobacteriosis10.1
12toxic encephalopathy10.1
13appendicitis10.1
14measles10.1
15listeriosis10.1
16bacteremia10.1
17periodontitis10.0LTA, LTF, IL1R1, IL1B
18familial cold autoinflammatory syndrome10.0IL1B, IL1R1, CASP1
19monocytic leukemia10.0CASP1, LTF, IL1R1, IL1B
20chronic infantile neurological cutaneous articular syndrome10.0IL1B, IL1R1, CASP1
21muckle-wells syndrome10.0CASP1, IL1R1, IL1B
22inflammatory bowel disease10.0CASP1, LTA, LTF, IL1R1, IL1B
23cerebral malaria10.0IL1R1, IL1B, VCL
24familial mediterranean fever10.0IL1B, CASP1, CARD17
25sjogren's syndrome10.0LTF
26meningitis10.0IL1B
27cowpox10.0PFN3, CASP1, CARD17
28bacterial vaginosis10.0IL1B, IL1R1, LTF
29pulmonary fibrosis10.0IL1B
30synovitis10.0IL1B, IL1R1
31influenza10.0CASP1, LTA, LTF
32crohn's disease10.0LTF
33gingivitis10.0IL1B, LTF
34myocardial infarction10.0CASP1, VCL
35chorioamnionitis10.0IL1B, IL1R1, LTF
36pemphigus vulgaris10.0VCL
37mastitis10.0IL1B, LTF
38endometriosis10.0IL1B, IL1R1
39sarcoidosis10.0IL1B, LTA
40allergic rhinitis10.0PFN4
41ulcerative colitis10.0LTF
42alzheimer's disease10.0IL1B, CASP1
43arthropathy10.0IL1B
44tuberculosis10.0IL1B
45atherosclerosis10.0IL1B, IL1R1
46respiratory failure10.0IL1B
47ascariasis9.9
48cryptosporidiosis9.9
49toxic megacolon9.9
50status epilepticus9.9

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to shigellosis

Clinical Features for Shigellosis

Drugs & Therapeutics for Shigellosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Shigellosis

Anatomical Context for Shigellosis

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Shigellosis:

33
Brain, Kidney, Colon, Breast, T cells, B cells, Appendix

FMA organs/tissues related to Shigellosis:

14
Epithelium of colon

Animal Models for Shigellosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Shigellosis

Sources:
51PubMed
See all sources

Articles related to Shigellosis:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
50 Years ago in The Journal of Pediatrics: shigellosis in infancy and childhood: clinical and cerebrospinal fluid findings. (23617974)
2013
2
Causative species and serotypes of shigellosis in mainland China: systematic review and meta-analysis. (23285073)
2012
3
Shigellosis outbreak at Addis Ababa University: March-April 2010. (23409399)
2011
4
Shigellosis outbreak linked to canteen-food consumption in a public institution: a matched case-control study. (21281549)
2011
5
Biennial hyperepidemic shigellosis in an observant Jewish community. (19602299)
2010
6
Green banana reduces clinical severity of childhood shigellosis: a double-blind, randomized, controlled clinical trial. (19319017)
2009
7
Geographic analysis of shigellosis in Vietnam. (18296100)
2008
8
Epidemiology and clinical presentation of shigellosis in children less than five years of age in rural Mozambique. (17984817)
2007
9
Changing epidemiology of shigellosis and emergence of ciprofloxacin-resistant Shigellae in India. (17122011)
2007
10
High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin. (16982910)
2006
11
Increasing single and multi-antibiotic resistance in Shigella species isolated from shigellosis patients in Sana'a, Yemen. (16883444)
2006
12
Shigellosis: disease burden, epidemiology and case management. (15807074)
2005
13
Laboratory-confirmed shigellosis in the United States, 1989-2002: epidemiologic trends and patterns. (15156473)
2004
14
The health belief model and factors relating to potential use of a vaccine for shigellosis in Kaeng Koi district, Saraburi province, Thailand. (15473520)
2004
15
Shigellosis: report of a workshop. (15663179)
2004
16
Effect of zinc supplementation on immune and inflammatory responses in pediatric patients with shigellosis. (14985220)
2004
17
Shigella interaction with intestinal epithelial cells determines the innate immune response in shigellosis. (12755366)
2003
18
Microbes and microbial toxins: paradigms for microbial-mucosal interactions III. Shigellosis: from symptoms to molecular pathogenesis. (11171613)
2001
19
Emergence of antimicrobial-resistant shigellosis in Oregon. (10722437)
2000
20
Shigellosis in children: a clinico-epidemiological comparison between Shigella dysenteriae type I and Shigella flexneri. (9924557)
1998
21
Severe shigellosis in childhood. (10437956)
1998
22
Epidemiologic features of domestically contracted shigellosis in a Tokyo Metropolitan Hospital. (21432458)
1997
23
Shigellosis on Indian reserves in Manitoba, Canada: its relationship to crowded housing, lack of running water, and inadequate sewage disposal. (9314814)
1997
24
Association of self-limited cytomegalovirus colitis and shigellosis in an immunocompetent patient. (8864682)
1996
25
Pathology of shigellosis and its complications. (8144144)
1994
26
Shigellosis in Jordanian children: a clinico-epidemiologic prospective study and susceptibility to antibiotics. (7853441)
1994
27
An outbreak of shigellosis in a slum colony of Delhi-1990. (8014439)
1993
28
Shigellosis complicated by perforated appendix. (8483634)
1993
29
Comparative efficacy of pivmecillinam and cotrimoxazole in acute shigellosis in children. (8052810)
1993
30
Shigellosis in Thai children: epidemiologic, clinical and laboratory features. (1565537)
1992
31
Shigellosis-associated encephalopathy. (1408493)
1992
32
Efficacy of norfloxacin for shigellosis: a double-blind randomised clinical trial. (1430968)
1992
33
Effects of a protein-rich diet during convalescence from shigellosis on catch-up growth, serum proteins, and insulin-like growth factor-I. (1287560)
1992
34
Prostacyclin concentrations in haemolytic uraemic syndrome after acute shigellosis. (1519970)
1992
35
Surveillance of shigellosis in rural Bangladesh: a 10 years review. (1861342)
1991
36
New approach to develop a vaccine design against shigellosis. (2204244)
1990
37
Shigellosis in New Brunswick. (2272103)
1990
38
Recurrent shigellosis complicating human immunodeficiency virus infection: failure of pre-existing antibodies to confer protection. (2642653)
1989
39
Therapy for shigellosis. (2738789)
1989
40
Hallucinations as an initial manifestation of childhood shigellosis. (2642551)
1989
41
A prospective epidemiologic study of shigellosis in the Israel Defense Forces: implications for the use of shigella vaccines. (3692749)
1987
42
Water-melon as a vehicle of transmission of shigellosis. (3303300)
1987
43
Shigellosis in Bangladesh. (3543150)
1987
44
Breast feeding as a determinant of severity in shigellosis. Evidence for protection throughout the first three years of life in Bangladeshi children. (3953549)
1986
45
Nalidixic acid for shigellosis. (6139566)
1983
46
Interruption of shigellosis by hand washing. (7101400)
1982
47
Shigellosis surveillance in Oklahoma: ten-year review, 1971-1980. (7175590)
1982
48
Shigellosis--United States, 1981. (6819448)
1982
49
Comparative efficacy of cephalexin and ampicillin for shigellosis and other types of acute diarrhea in infants and children. (1096800)
1975
50
Prolonged septicaemic salmonellosis intercurrent with Schistosomiasis mansoni (intestinal polyposis, hepatic and cardiopulmonary forms) Chagas' disease, cerebral cysticercosis, taeniasis, shigellosis, ancylostomiasis, ascariasis and chronic malnutrition. Clinopathologic discussion. (4994067)
1971

Genetic Variations for Shigellosis

Expression for genes affiliated with Shigellosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Shigellosis

Search GEO for disease gene expression data for Shigellosis.

Pathways for genes affiliated with Shigellosis

Sources:
52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 54Reactome, 53R&D Systems, 12EMD Millipore, 60Tocris Bioscience, 56SinoBiological
See all sources

Pathways related to Shigellosis according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CASP1, MAPK12, LTA, IL1R1, IL1B, VCL
2
Hide members
10.5IL1R1, LTA, CASP1
310.5IL1R1, IL1B, VCL
4
Hide members
10.5IL1B, IL1R1, CASP1
5
Hide members
10.5CASP1, IL1R1, IL1B
610.5LTA, IL1R1, IL1B
7
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B, VCL
8
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
9
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
10
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1R1, IL1B
1110.5IL1B, CASP1
1210.5ARPC4, ARPC5L, RHOG, VCL
13
Hide members
10.5ARPC4, ARPC5L, PFN4, PFN3, VCL
14
Hide members
10.5CASP1, ARPC4, MAPK12, MAPK13, VASP, IL1R1
15
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1B
16
Hide members
10.5CASP1, MAPK12, MAPK13, LTA, IL1B
17
Hide members
10.5CASP1, MAPK12, MAPK13, IL1R1, IL1B
18
Hide members
10.5CASP1, MAPK12, MAPK13, IL1R1, IL1B
19
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B
20
Hide members
10.5MAPK12, MAPK13, LTA, IL1R1, IL1B
2110.5IL1B, CASP1, PFN3, PFN4, MAPK13, MAPK12
22
Hide members
10.5CASP1, MAPK12, MAPK13, LTA
2310.5ARPC4, ARPC5L, VASP
2410.5ARPC4, ARPC5L, RHOG, MAPK12, MAPK13, PFN4
25
Immune response IFN gamma signaling pathway
Hide members
10.5CASP1, MAPK12, MAPK13, IL1B
26
Hide members
10.5IL1B, MAPK13, MAPK12, CASP1
2710.5IL1B, MAPK13, MAPK12, CASP1
2810.5MAPK12, MAPK13, LTA, IL1B
29
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
30
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
31
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
3210.5MAPK12, MAPK13, IL1R1, IL1B
33
Hide members
10.5MAPK12, MAPK13, IL1R1, IL1B
3410.5VCL, VASP, MAPK13, MAPK12
35
Hide members
10.5VCL, VASP, MAPK13, MAPK12
36
Hide members
10.5MAPK13, MAPK12, CASP1
37
Hide members
10.5MAPK13, MAPK12, CASP1
38
Hide members
10.5MAPK13, MAPK12, CASP1
3910.5MAPK12, MAPK13, IL1B
4010.5MAPK13, MAPK12
4110.5MAPK13, MAPK12
4210.5MAPK12, MAPK13
4310.5MAPK13, MAPK12, ARPC4

Compounds for genes affiliated with Shigellosis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 50PharmGKB
See all sources

Compounds related to Shigellosis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.9IL1B, IL1R1, LTF, LTA, CASP1
2endotoxin4510.9CASP1, LTA, LTF, IL1R1, IL1B
3tenidap45 2911.9LTF, IL1R1, IL1B
4neopterin4510.9LTA, LTF, IL1R1, IL1B
5anakinra45 1111.9IL1B, IL1R1, CASP1
6indomethacin45 60 29 1113.9LTA, LTF, VASP, IL1R1, IL1B
7as 10160 4511.9IL1B, IL1R1, CASP1
8minocycline45 1111.9CASP1, LTF, IL1B
9actinomycin d4510.9CASP1, LTA, LTF, IL1R1, IL1B
10cuprophan4510.9IL1B, IL1R1, CASP1
11acetyl-tyr-val-ala-asp-cho4510.9CASP1, IL1B
12lipoteichoic acid4510.9IL1B, IL1R1, LTA
13hyaluronic acid45 2411.9IL1B, IL1R1, LTF, LTA
14sb 20358045 6011.9IL1B, IL1R1, MAPK13, MAPK12, CASP1
15vegf4510.9CASP1, LTA, LTF, IL1R1, IL1B, VCL
16serine4510.9CASP1, MAPK12, MAPK13, LTA, LTF, VASP
17etanercept45 50 1112.9LTA, IL1R1, IL1B
18pge24510.9CASP1, LTA, LTF, IL1R1, IL1B
19il 104510.9LTA, IL1R1, IL1B
20nitric oxide45 11 2412.9CASP1, LTA, VASP, IL1R1, IL1B, VCL
21infliximab45 50 1112.9IL1B, IL1R1, LTA
22diphenyleneiodonium4510.8IL1B, IL1R1, CASP1
23peptidoglycan45 2911.8CASP1, IL1R1, IL1B
24threonine4510.8CASP1, MAPK12, LTA, VASP, IL1R1, VCL
25ivig4510.8IL1B, IL1R1, LTA
26aspirin45 50 29 2413.8CASP1, VASP, IL1R1, IL1B
27cycloheximide4510.8CASP1, LTA, IL1R1, IL1B, VCL
28ibuprofen45 29 50 11 2414.8IL1B, IL1R1, LTF
29n acetylcysteine4510.8IL1B, IL1R1, LTF, CASP1
30tlck4510.8CASP1, IL1B
3112-o-tetradecanoylphorbol 13-acetate4510.7MAPK13, LTA, IL1R1, VCL
32muramyl dipeptide45 2911.7CASP1, IL1B
33ag-1264510.7CASP1, IL1B
34h2o24510.7CASP1, LTA, LTF, IL1R1, VCL
35monosodium urate4510.7IL1R1, IL1B
36fibrinogen4510.7VCL, IL1R1, VASP, LTF
37leukotriene b445 60 2412.6LTF, IL1R1, IL1B
38toxin-14510.6LTA, IL1B
394-ipp6010.5IL1R1, IL1B
40gold sodium thiomalate4510.5IL1B, IL1R1
41git 276010.4IL1R1, IL1B
42cytochalasin4510.2LTF, VCL

GO Terms for genes affiliated with Shigellosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.5ARPC4, RHOG, MAPK12, MAPK13, BLOC1S3, VASP
2cytoskeletonGO:00585610.2VCL, PFN3, PFN4, ARPC5L, CCIN

Biological processes related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 beta productionGO:03261110.5IL1B, CASP1
2cellular response to organic substanceGO:07131010.5IL1B, CASP1
3lymph node developmentGO:04853510.4CD248, LTA
4response to ATPGO:03319810.2IL1B, CASP1

Molecular functions related to Shigellosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MAP kinase activityGO:00470710.5MAPK13, MAPK12
2actin bindingGO:00377910.2VCL, VASP, PFN3, PFN4, ARPC5L

Products for genes affiliated with Shigellosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Shigellosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet