MCID: SHG001
MIFTS: 54

Shigellosis malady

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Shigellosis

Aliases & Descriptions for Shigellosis:

Name: Shigellosis 12 50 56 52 3 14
Dysentery, Bacillary 42 69
Shigella Flexneri Infectious Disease 12
Shigella Boydii Infectious Disease 12
Shigella Sonnei Infectious Disease 12
Shigella Gastroenteritis 12
Bacillary Dysentery 12
Shigella Infections 69

Characteristics:

Orphanet epidemiological data:

56
shigellosis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


Summaries for Shigellosis

NIH Rare Diseases : 50 shigellosis is a disease caused by a group of bacteria called shigella. shigella is very contagious. shigella germs are present in the stools of infected individuals for up to two weeks after symptoms have resolved. individuals may be exposed through direct contact with an infected person or through contaminated food, water (both drinking and recreational water), or surfaces. though anyone can get shigellosis, young children are most at risk. symptoms of shigellosis usually begin one to two days after exposure and include diarrhea, abdominal pain, and fever. in otherwise healthy individuals, the symptoms usually resolve in 5-7 days. those with mild shigellosis may need only rest and self-care measures to avoid dehydration (drinking fluids and electrolyte solutions). for more severe cases, antibiotics may be prescribed though some cases of shigellosis have been found to be resistant to antibiotics. laboratory tests can be performed to determine which antibiotics are likely to be effective in an individual case. most people make a full recovery, though it may take several months for bowel habits to return to normal. complications are rare but may include post-infectious arthritis, bloodstream infections, seizures, or hemolytic-uremic syndrome (hus). last updated: 10/5/2016

MalaCards based summary : Shigellosis, also known as dysentery, bacillary, is related to mesangial proliferative glomerulonephritis and conidiobolomycosis. An important gene associated with Shigellosis is CASP1 (Caspase 1), and among its related pathways/superpathways are Shigellosis and Innate Immune System. The drugs Zinc and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and t cells, and related phenotypes are cellular and cardiovascular system

CDC : 3 Shigellosis is an infectious disease caused by a group of bacteria called Shigella (shih-GEHL-uh). Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacteria. Shigellosis usually resolves in 5 to 7 days. Some people who are infected may have no symptoms at all, but may still pass the Shigella bacteria to others. The spread of Shigella can be stopped by frequent and careful handwashing with soap and taking other hygiene measures.

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in epithelium of colon, has material basis in Shigella boydii, has material basis in Shigella dysenteriae, has material basis in Shigella flexneri, or has material basis in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.

Wikipedia : 71 Shigellosis is a type of diarrhea caused by a bacterial infection with Shigella. Symptoms generally... more...

Related Diseases for Shigellosis

Diseases related to Shigellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
id Related Disease Score Top Affiliating Genes
1 mesangial proliferative glomerulonephritis 10.1 CD79A CXCL8
2 conidiobolomycosis 10.1 CXCL8 IL10
3 inflammatory bowel disease 20 10.1 CXCL8 IL10
4 acute female pelvic peritonitis 10.1 CD79A TTR
5 ritscher-schinzel syndrome 1 10.1 CD79A CXCL8
6 microglandular adenosis of breast 10.1 CXCL8 IL10
7 amyotrophic lateral sclerosis 15, with or without frontotemporal dementia 10.1 CDC42 CTTN SRC
8 classic type lipoma 10.0 CASP1 CXCL8 IL10
9 neonatal hypoxic and ischemic brain injury 10.0 CXCL8 IL10
10 salmonellosis 10.0
11 cholera 10.0
12 coronary arterial fistulas 10.0 CXCL8 IL10 LTF
13 paranasal sinus sarcoma 10.0 CD79A CXCL8 TTR
14 blue toe syndrome 10.0 CXCL8 IL10 LTA
15 dysentery 10.0
16 nasopharyngitis 10.0 CD79A CXCL8 LTA
17 plantar wart 10.0 CD79A CXCL8 IL10
18 thymic neuroendocrine carcinoma 10.0 CXCL8 LTA
19 eyelid neoplasm 10.0 CD79A CXCL8 IL10
20 acquired polycythemia 10.0 CD79A CXCL8 IL10
21 breast apocrine carcinoma in situ 10.0 CD79A CXCL8 IL10
22 stenosis of lacrimal sac 9.9 CD79A CXCL8 LTF
23 xanthogranulomatous cholecystitis 9.9 CD79A CXCL8 IL10
24 nephropathy with pretibial epidermolysis bullosa and deafness 9.9 CD79A CXCL8 IL10
25 uterine ligament clear cell adenocarcinoma 9.9 CD79A CXCL8 IL10
26 spastic entropion 9.9 CD79A LTF TTR
27 bone angioendothelial sarcoma 9.9 CD79A CXCL8 IL10
28 encephalopathy 9.9
29 diarrhea 9.9
30 acute chest syndrome 9.9 CD79A CXCL8 IL10
31 diabetic angiopathy 9.9 CD79A IL10 LTA
32 inflammatory breast carcinoma 9.9 CD79A IL10 LTA
33 type 2 papillary adenoma of the kidney 9.9 CD79A IL10 LTA
34 scleral disease 9.8 CD79A IL10 LTA
35 hemolytic-uremic syndrome 9.8
36 typhoid fever 9.8
37 pulmonary eosinophilia 9.8 CXCL8 IL10 IRAK4
38 atrial septal defect 6 9.8 CD79A IL10 LTA
39 keratomalacia 9.8 CASP1 CD79A CXCL8 IL10
40 membranoproliferative glomerulonephritis 9.8 CD79A IL10 LTF
41 goodpasture syndrome 9.8 CD79A CXCL8 IL10 LTA
42 hepatitis 9.8
43 mucositis 9.8
44 childhood malignant hemangiopericytoma 9.8 CD79A CXCL8 IL10 LTF
45 bacteremia 9.7
46 listeriosis 9.7
47 toxic encephalopathy 9.7
48 acute diarrhea 9.7
49 hepatitis a 9.7
50 pneumonia 9.7

Graphical network of the top 20 diseases related to Shigellosis:



Diseases related to Shigellosis

Symptoms & Phenotypes for Shigellosis

MGI Mouse Phenotypes related to Shigellosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 BTRC CASP1 CD79A CTTN IL10 IRAK4
2 cardiovascular system MP:0005385 9.97 CRK CTTN IL10 LTA PFN1 VCL
3 hematopoietic system MP:0005397 9.96 SRC BTRC CASP1 CD79A CTTN IL10
4 homeostasis/metabolism MP:0005376 9.85 BTRC CASP1 CD79A CRK IL10 IRAK4
5 immune system MP:0005387 9.65 BTRC CASP1 CD79A CTTN IL10 IRAK4
6 neoplasm MP:0002006 9.1 BTRC CASP1 CD79A IL10 LTF SRC

Drugs & Therapeutics for Shigellosis

Drugs for Shigellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved Phase 3 7440-66-6 32051 23994
2
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173
3 Anti-Bacterial Agents Phase 3,Phase 2
4 rifamycin SV Phase 3
5 Gastrointestinal Agents Phase 3,Phase 1
6 Nucleic Acid Synthesis Inhibitors Phase 3
7 Trace Elements Phase 3
8 Vaccines Phase 3,Phase 2,Phase 1
9 Immunoglobulins Phase 3
10 Anti-Infective Agents Phase 3,Phase 2
11 Rifamycins Phase 3
12 Antibodies Phase 3
13 Micronutrients Phase 3
14
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
15
Butyric Acid Experimental Phase 2 107-92-6 264
16 Antibiotics, Antitubercular Phase 2
17
Histamine Phosphate Phase 2 51-74-1 65513
18 Neurotransmitter Agents Phase 2
19 Histamine Antagonists Phase 2
20 Pharmaceutical Solutions Phase 2
21
Aluminum hydroxide Approved Phase 1 21645-51-2
22 Adjuvants, Immunologic Phase 1
23 Antacids Phase 1
24 Anti-Ulcer Agents Phase 1
25 Aluminum sulfate Phase 1
26
Formaldehyde Approved, Vet_approved 50-00-0 712
27 Ether
28 Disinfectants

Interventional clinical trials:

(show all 37)
id Name Status NCT ID Phase
1 Safety, Immunogenicity and Efficacy of Shigella Conjugate Vaccines in 1-4 Year Olds in Israel Completed NCT00368316 Phase 3
2 Zinc Supplementation in Shigella Patients Completed NCT00321126 Phase 3
3 Rifaximin for Prevention of Travellers' Diarrhea Completed NCT00742469 Phase 3
4 Therapeutic Induction of Endogenous Antibiotics Completed NCT00800930 Phase 2
5 A Study of the Safety and Immune Response of 2 Doses of a New Shigella Vaccine in Kenyan Adults Completed NCT02676895 Phase 2
6 Healthy Adult Volunteer Study for Two Doses of a Shigella Vaccine Completed NCT00210288 Phase 2
7 Shigella Flexneri 2a Invaplex 50 Vaccine Dose Finding and Assessment of Protection Completed NCT00485134 Phase 1, Phase 2
8 Safety and Efficacy Study of WRSS1, a Shigella Sonnei Vaccine Candidate Completed NCT01080716 Phase 1, Phase 2
9 Safety, Immunogenicity and Efficacy Study of Inactivated Whole Cell Shigella Flexneri 2a Vaccine With and Without dmLT in Adults Recruiting NCT03038243 Phase 2
10 Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a Active, not recruiting NCT02646371 Phase 2
11 Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIb Terminated NCT00866242 Phase 2
12 Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection: Phase IIa Terminated NCT00866476 Phase 2
13 Safety and Efficacy Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella Infection Using cGMP Completed NCT01531530 Phase 1
14 Shigella Sonnel O-SPC/rBRU Conjugate Vaccine Completed NCT01369927 Phase 1
15 A Phase 1, Dose Escalation Study, to Evaluate a New Shigella Sonnei Vaccine in Healthy Adults. Completed NCT02017899 Phase 1
16 Evaluate a New Shigella Sonnei Vaccine Administered Either by Intradermal, Intranasal or Intramuscular Route in Healthy Adults Completed NCT02034500 Phase 1
17 Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults Completed NCT01509846 Phase 1
18 Safety and Reactogenicity of Bioconjugate Vaccine to Prevent Shigella Completed NCT01069471 Phase 1
19 Safety and Immunogenicity of Two Live, Attenuated Oral Shigella Sonnei Vaccines: WRSs2 and WRSs3 Completed NCT01336699 Phase 1
20 Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2a Completed NCT02388009 Phase 1
21 Invaplex 50 Vaccine Dose-Ranging Completed NCT00082069 Phase 1
22 Effect of 15g Daily Consumption of NUTRIOSE on Healthy Volunteers Microbiota. Completed NCT01897649 Phase 1
23 Shigella Sonnei 53G Challenge Recruiting NCT02816346 Phase 1
24 A Study to Evaluate Safety and Immunogenicity of 1 Booster Dose of 1790GAHB Vaccine in Healthy Adults Primed With 3 Doses of 1790GAHB Vaccine in Study H03_01TP Compared to 1 Vaccination of 1790GAHB in Either Subjects Who Received Placebo in the Same Study Recruiting NCT03089879 Phase 1
25 Phase 1 Study of dmLT ID Vaccination in Healthy Adults Recruiting NCT02531685 Phase 1
26 Safety and Immunogenicity of Artificial Invaplex (Shigella Flexneri 2a InvaplexAR) Administered Intranasally to Healthy, Adult Volunteers Active, not recruiting NCT02445963 Phase 1
27 Shigella WRSS1 Vaccine Trial in Bangladesh Not yet recruiting NCT02934178 Phase 1
28 SF2a-TT15 Conjugate Vaccine in Healthy Adult Volunteers Not yet recruiting NCT02797236 Phase 1
29 Shigella Sonnei OSPC-rDT Conjugate Vaccine Withdrawn NCT01399424 Phase 1
30 Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli Infections Unknown status NCT01638039
31 A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty Hospitals Unknown status NCT01612572
32 Experimental Phage Therapy of Bacterial Infections Unknown status NCT00945087
33 The Long Term Clinical Course of Postinfectious Irritable Bowel Syndrome After Shigellosis; A 10 Year Follow up Study Completed NCT02516683
34 Safety Study of Live Shigella Vaccine in Bangladeshi Adults and Children Completed NCT01813071
35 Evaluation of a Diagnostic Enteric Card for Management of Diarrhea Completed NCT00736567
36 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
37 COmparison of MicroBiota AccordIng to Age in Crohn's Disease (COMeBACk) Recruiting NCT02839317

Search NIH Clinical Center for Shigellosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: dysentery, bacillary

Genetic Tests for Shigellosis

Anatomical Context for Shigellosis

MalaCards organs/tissues related to Shigellosis:

39
Colon, Testes, T Cells, Breast, Neutrophil, Kidney, Appendix

The Foundational Model of Anatomy Ontology organs/tissues related to Shigellosis:

18
Epithelium Of Colon

Publications for Shigellosis

Articles related to Shigellosis:

(show top 50) (show all 537)
id Title Authors Year
1
A review of the public health management of shigellosis in Australia in the era of culture-independent diagnostic testing. ( 27774718 )
2016
2
Shigellosis in Nepal: 13A years review of nationwide surveillance. ( 27814742 )
2016
3
True Prevalence of Shigellosis in Indian Children with Acute Gastroenteritis: Have We Been Missing the Diagnosis? ( 27061990 )
2016
4
Shigellosis in men who have sex with men: an overlooked opportunity to counsel with pre-exposure prophylaxis for HIV. ( 26945593 )
2016
5
Molecular Characterization of Shigella sonnei: An Increasingly Prevalent Etiologic Agent of Shigellosis in Guizhou Province, Southwest of China. ( 27195892 )
2016
6
Development of a live attenuated bivalent oral vaccine against Shigella sonnei shigellosis and typhoid fever. ( 27803169 )
2016
7
Shigellosis. ( 27556171 )
2016
8
A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity. ( 26918643 )
2016
9
Shigellosis murine model established by intraperitoneal and intranasal route of administration: a comparative comprehension overview. ( 27664045 )
2016
10
Notes from the Field: Shigellosis Outbreak Among Men Who Have Sex with Men and Homeless Persons - Oregon, 2015-2016. ( 27513523 )
2016
11
Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection Against Shigellosis in a Controlled Human Challenge Study. ( 27927680 )
2016
12
Shigellosis and Pregnancy in French Guiana: Obstetric and Neonatal Complications. ( 27114299 )
2016
13
Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome after Shigellosis: A 10-year Follow-up Study. ( 26908484 )
2016
14
Shigellosis: high rates of antibiotic resistance necessitate new treatment recommendations. ( 27078594 )
2016
15
Shigellosis: Epidemiology in India. ( 27487999 )
2016
16
Recent Outbreaks of Shigellosis in California Caused by Two Distinct Populations of Shigella sonnei with either Increased Virulence or Fluoroquinolone Resistance. ( 28028547 )
2016
17
Use of a culture-independent gastrointestinal multiplex PCR panel during a Shigellosis outbreak: considerations for clinical laboratories and public health. ( 25568430 )
2015
18
Intensified shigellosis epidemic associated with sexual transmission in men who have sex with men--Shigella flexneri and S. sonnei in England, 2004 to end of February 2015. ( 25953129 )
2015
19
Disparities of Shigellosis Rates among California Children by Race/Ethnicity and Census Tract Poverty Level, 2000-2010. ( 26020406 )
2015
20
Outbreak of Shigellosis in a Homeless Shelter With Healthcare Worker Transmission-British Columbia, April 2015. ( 26330023 )
2015
21
Shigella sonnei bacteraemia occurring in a young man with shigellosis. ( 25920737 )
2015
22
Invasive shigellosis in MSM. ( 26429891 )
2015
23
Shigellosis in Subjects with Traveler's Diarrhea Versus Domestically Acquired Diarrhea: Implications for Antimicrobial Therapy and Human Immunodeficiency Virus Surveillance. ( 26195465 )
2015
24
Shigella Infections in Household Contacts of Pediatric Shigellosis Patients in Rural Bangladesh. ( 26484778 )
2015
25
Shigellosis Outbreak in Al Batinah South Governorate, Oman: Case-control study. ( 26357558 )
2015
26
Microbiota that affect risk for shigellosis in children in low-income countries. ( 25625766 )
2015
27
Shigellosis in refugees, Austria, July to November 2015. ( 26676065 )
2015
28
Fulminant Shigellosis in a HIV Patient. ( 25821609 )
2015
29
Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study. ( 25936611 )
2015
30
Virulence factors associated with pediatric shigellosis in Brazilian Amazon. ( 24877110 )
2014
31
A mouse model of shigellosis by intraperitoneal infection. ( 23904297 )
2014
32
Investigation of key interventions for shigellosis outbreak control in China. ( 24736407 )
2014
33
Report: prevalence of shigellosis in three different areas of Karachi. ( 24577930 )
2014
34
Shigellosis in Poland in 2012. ( 25135504 )
2014
35
Shigellosis with decreased susceptibility to azithromycin. ( 25361413 )
2014
36
Cholera and shigellosis: different epidemiology but similar responses to climate variability. ( 25229494 )
2014
37
Recent trends in the epidemiology of shigellosis in Israel. ( 24559503 )
2014
38
Travel-related shigellosis in Quebec, Canada: an analysis of risk factors. ( 24889090 )
2014
39
A large outbreak of shigellosis commencing in an internally displaced population, Papua New Guinea, 2013. ( 25648967 )
2014
40
Risk factors for diarrhea hospitalization in Bangladesh, 2000-2008: a case-case study of cholera and shigellosis. ( 25127553 )
2014
41
Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. ( 24680068 )
2014
42
Clinical and microbiological profiles of shigellosis in children. ( 25895190 )
2014
43
Use of population-based surveillance to define the high incidence of shigellosis in an urban slum in Nairobi, Kenya. ( 23505506 )
2013
44
Shigellosis in Bay of Bengal Islands, India: clinical and seasonal patterns, surveillance of antibiotic susceptibility patterns, and molecular characterization of multidrug-resistant Shigella strains isolated during a 6-year period from 2006 to 2011. ( 23990135 )
2013
45
Shigellosis in Poland in 2011. ( 24040720 )
2013
46
Housefly population density correlates with shigellosis among children in Mirzapur, Bangladesh: a time series analysis. ( 23818998 )
2013
47
The anti-shigellosis activity of the methanol extract of Picralima nitida on Shigella dysenteriae type I induced diarrhoea in rats. ( 23957940 )
2013
48
Magnitude of drug resistant shigellosis in Nepalese patients. ( 25848501 )
2013
49
Evaluation of underreporting of salmonellosis and shigellosis hospitalised cases in Greece, 2011: results of a capture-recapture study and a hospital registry review. ( 24060206 )
2013
50
Comparison of clinical and laboratory characteristics of intestinal amebiasis with shigellosis among patients visiting a large urban diarrheal disease hospital in Bangladesh. ( 23775017 )
2013

Variations for Shigellosis

Expression for Shigellosis

Search GEO for disease gene expression data for Shigellosis.

Pathways for Shigellosis

Pathways related to Shigellosis according to KEGG:

37
id Name Kegg Source Accession
1 Shigellosis hsa05131

Pathways related to Shigellosis according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 BTRC CASP1 CD79A CDC42 CRK CXCL8
2
Show member pathways
13.1 CASP1 CDC42 CRK CXCL8 IL10 LTA
3
Show member pathways
13.09 BTRC CASP1 CRK CXCL8 IL10 IRAK4
4
Show member pathways
12.71 CDC42 CRK CTTN PFN1 SRC
5
Show member pathways
12.48 CDC42 CRK PFN1 SRC VCL
6 12.47 CDC42 CRK PFN1 SRC VCL
7
Show member pathways
12.43 CDC42 CTTN PFN1 SRC
8 12.41 CDC42 CTTN PFN1 VCL
9
Show member pathways
12.32 CDC42 CRK IRAK4 SRC
10
Show member pathways
12.29 CDC42 CRK SRC VCL
11
Show member pathways
12.03 CXCL8 IL10 LTA
12 11.95 BTRC CDC42 SRC
13
Show member pathways
11.88 CDC42 CRK SRC
14 11.78 CXCL8 IL10 VCL
15 11.77 CXCL8 IRAK4 LTA
16
Show member pathways
11.74 CDC42 SRC VCL
17 11.69 CASP1 CDC42 CXCL8 PFN1
18 11.62 CDC42 SRC VCL
19 11.57 CDC42 IRAK4 SRC
20 11.56 CRK CXCL8 SRC
21 11.55 CASP1 CXCL8 IL10 IRAK4
22 11.48 CDC42 CTTN SRC
23 11.46 CRK SRC VCL
24 11.44 CDC42 CRK SRC
25 11.27 CDC42 CTTN SRC
26 11.23 CDC42 CRK CTTN SRC VCL
27 11.05 CDC42 CRK SRC
28 11.04 BTRC CDC42 CRK CTTN CXCL8 PFN1
29 10.98 CDC42 CRK CTTN SRC
30 10.81 CTTN CXCL8 SRC
31 10.78 BTRC SRC

GO Terms for Shigellosis

Cellular components related to Shigellosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.77 BTRC CASP1 CD79A CDC42 CRK CTTN
2 extracellular space GO:0005615 9.7 CXCL8 IL10 IRAK4 LTA LTF PFN1
3 podosome GO:0002102 8.8 CTTN SRC VCL

Biological processes related to Shigellosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.63 CDC42 CRK SRC
2 cellular response to lipopolysaccharide GO:0071222 9.61 CXCL8 IL10 SRC
3 positive regulation of smooth muscle cell migration GO:0014911 9.48 CRK SRC
4 negative regulation of growth of symbiont in host GO:0044130 9.4 IL10 LTA
5 response to molecule of bacterial origin GO:0002237 9.37 CXCL8 IL10
6 ephrin receptor signaling pathway GO:0048013 9.33 CDC42 CRK SRC
7 branching involved in mammary gland duct morphogenesis GO:0060444 9.32 BTRC SRC
8 epithelial cell-cell adhesion GO:0090136 9.26 CDC42 VCL
9 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.13 CDC42 CRK SRC
10 positive regulation of cytokine secretion GO:0050715 8.8 CASP1 IL10 SRC

Molecular functions related to Shigellosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 BTRC CASP1 CD79A CDC42 CRK CTTN
2 cadherin binding GO:0045296 9.46 CTTN PFN1 SRC VCL
3 protein phosphorylated amino acid binding GO:0045309 8.62 BTRC CRK

Sources for Shigellosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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