MCID: SHR001
MIFTS: 52

Short Bowel Syndrome malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Short Bowel Syndrome

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NIH Rare Diseases:42 Short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. the main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. examples of treatment include diet and nutritional support, and in some cases intestinal transplantation. last updated: 4/29/2011

MalaCards based summary: Short Bowel Syndrome, also known as acquired short bowel syndrome, is related to intestinal pseudo-obstruction and diarrhea. An important gene associated with Short Bowel Syndrome is CLMP (CXADR-like membrane protein), and among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. The compounds enterogastrone and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are growth/size/body and nervous system.

Wikipedia:65 Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder... more...

Aliases & Classifications for Short Bowel Syndrome

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Short Bowel Syndrome, Aliases & Descriptions:

Name: Short Bowel Syndrome 8 42 10 44 62
Acquired Short Bowel Syndrome 8 62
 
Short Gut Syndrome 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:10605
MeSH34 D012778

Related Diseases for Short Bowel Syndrome

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Graphical network of the top 20 diseases related to Short Bowel Syndrome:



Diseases related to short bowel syndrome

Symptoms for Short Bowel Syndrome

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Drugs & Therapeutics for Short Bowel Syndrome

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Drug clinical trials:

Search ClinicalTrials for Short Bowel Syndrome

Search NIH Clinical Center for Short Bowel Syndrome

Genetic Tests for Short Bowel Syndrome

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Anatomical Context for Short Bowel Syndrome

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MalaCards organs/tissues related to Short Bowel Syndrome:

32
Small intestine, Liver, Colon, Bone, Skin, Heart, Kidney, Pancreas, Thyroid, Breast, Testes

Animal Models for Short Bowel Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Short Bowel Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.6NTS, DPP4, SST, FLNA, PYY
2MP:00036317.3PYY, FLNA, SST, CCK, NTS
3MP:00053767.0NTS, DPP4, CCK, SST, FLNA, PYY

Publications for Short Bowel Syndrome

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Articles related to Short Bowel Syndrome:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Bowel-associated dermatosis-arthritis syndrome in an adolescent with short bowel syndrome. (25160016)
2014
2
Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease. (24999016)
2014
3
Short bowel syndrome and clopidogrel non-responsiveness: a new indication for platelet aggregometry? (25115778)
2014
4
Temporary Parenteral Tacrolimus Requirement due to Unexplained Low Through Levels in a Liver Transplant Patient with Short Bowel Syndrome. (25013677)
2014
5
Persistent metabolic acidosis in a hemodialyzed patient with short bowel syndrome. (23774551)
2013
6
Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations. (23037936)
2013
7
Key issues in addressing the clinical and humanistic burden of short bowel syndrome in the US. (23480444)
2013
8
Study of teduglutide effectiveness in parenteral nutrition-dependent short-bowel syndrome subjects. (24134154)
2013
9
Vitamin K status in patients with short bowel syndrome. (22633417)
2012
10
Short bowel syndrome in children: current and potential therapies. (22452596)
2012
11
Intestinal rehabilitation and bowel reconstructive surgery: improved outcomes in children with short bowel syndrome? (22197947)
2012
12
Long-term nutritional assessment of patients with severe short bowel syndrome managed with home enteral nutrition and oral intake. (22470032)
2011
13
Plasma citrulline as marker of bowel adaptation in children with short bowel syndrome. (21630079)
2011
14
Intestinal lengthening in adult patients with short bowel syndrome. (20734155)
2010
15
The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. (20171649)
2010
16
Enteral nutrition in children with short-bowel syndrome: current evidence and recommendations for the clinician. (20184992)
2010
17
Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. (19179884)
2009
18
Pediatric short-bowel syndrome: the cost of comprehensive care. (19064515)
2008
19
Growth and nutritional aspects of infantile short bowel syndrome for the past 2 decades. (18970941)
2008
20
Congenital short bowel syndrome: a case report and review of the literature. (18209785)
2008
21
Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome. (17307727)
2007
22
Autologous gastrointestinal reconstruction for short bowel syndrome. (17260708)
2007
23
Intestinal transplantation for short bowel syndrome and gastrointestinal failure: current consensus, rewarding outcomes, and practical guidelines. (16473061)
2006
24
Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. (16244538)
2005
25
Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome. (15991189)
2005
26
Recurrent D-lactic acidosis in a child with short bowel syndrome. (15927940)
2005
27
Small bowel volvulus leading to gangrene and short bowel syndrome. (15670531)
2005
28
Treatment of restless legs syndrome with subcutaneous apomorphine in a patient with short bowel syndrome. (15726274)
2005
29
Dipeptidyl-peptidase IV in patients with short bowel syndrome. (16169633)
2005
30
Enteric-coated cholylsarcosine microgranules for the treatment of short bowel syndrome. (15638993)
2005
31
A useful experimental model of short bowel syndrome. (14761823)
2004
32
Surgical rehabilitation of intestine in short bowel syndrome. (15118580)
2004
33
A prospective within-patient comparison clinical trial on the effect of parenteral cimetidine for improvement of fluid secretion and electrolyte balance in patients with short bowel syndrome. (15532817)
2004
34
Intestinal rehabilitation and the short bowel syndrome: part 1. (15233682)
2004
35
Total parenteral nutrition, intestinal adaptation, and short bowel syndrome. (14990282)
2004
36
Fasting breath hydrogen concentration in short bowel syndrome patients with colon incontinuity before and after antibiotic therapy. (14962684)
2004
37
New and emerging therapies for short bowel syndrome in children. (12895135)
2003
38
Low-fat diet impairs postresection intestinal adaptation in a rat model of short bowel syndrome. (12891489)
2003
39
Indications for specific therapy in the rehabilitation of patients with the short-bowel syndrome. (14642856)
2003
40
Effects of enteral arginine supplementation on the structural intestinal adaptation in a rat model of short bowel syndrome. (12870793)
2003
41
Adverse effects of liver dysfunction and portal hypertension on intestinal adaptation in short bowel syndrome in children. (12488176)
2002
42
Does ileal reverse segment in rats with short bowel syndrome change intestinal morphology? (11840034)
2002
43
Effect of transforming growth factor-alpha on intestinal adaptation in a rat model of short bowel syndrome. (12505047)
2002
44
Pharmacotherapy and growth factors in the treatment of short bowel syndrome. (11329609)
2001
45
Treatment of short-bowel syndrome. (11706294)
2001
46
Severe convulsant hypomagnesaemia and short bowel syndrome. (11439801)
2001
47
Combination therapy with Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides dramatically improved the intestinal function in a girl with short bowel syndrome: a novel synbiotics therapy for intestinal failure. (11575457)
2001
48
Intestinal ornithine decarboxylase in short bowel syndrome patients with oral diet. (11327746)
2001
49
Clinical use of growth hormone and glutamine in short bowel syndrome. (10488599)
1999
50
Warfarin resistance in a patient with short-bowel syndrome. (3614776)
1987

Variations for Short Bowel Syndrome

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Expression for genes affiliated with Short Bowel Syndrome

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Expression patterns in normal tissues for genes affiliated with Short Bowel Syndrome

Search GEO for disease gene expression data for Short Bowel Syndrome.

Pathways for genes affiliated with Short Bowel Syndrome

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Compounds for genes affiliated with Short Bowel Syndrome

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Compounds related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1enterogastrone449.9CCK, PYY
2taurodeoxycholate449.9CCK, SST
3minigastrin449.9CCK, SST
4vapreotide44 28 1111.8SST, CCK
5alosetron44 1110.8SST, CCK
6glipizide44 50 1111.8SST, DPP4
7bethanechol44 28 1111.8CCK, SST
8rimonabant44 28 1111.7DPP4, CCK
9cyproheptadine44 28 1111.7SST, CCK
10orlistat44 61 1111.5CCK, PYY
11intralipid449.5CCK, SST, PYY
12pirenzepine44 28 1111.5CCK, SST
13omeprazole44 50 28 24 1113.5CCK, SST, PYY
14cyclo(his-pro)449.5NTS, CCK
15pramlintide44 1110.5DPP4, CCK, PYY
16incretin449.5PYY, CCK, DPP4
17enterostatin449.4NTS, CCK
18loperamide44 24 1111.4CCK, SST
19alpha msh449.4NTS, CCK
20carbohydrates449.3DPP4, CCK, PYY
21clonidine44 50 28 1112.2PYY, SST, NTS
22loxiglumide449.1NTS, CCK, SST
23dtpa449.1NTS, CCK, SST
24tetrodotoxin44 61 2811.1PYY, CCK, NTS
25naloxone44 28 50 1112.1NTS, CCK, SST
26cocaine44 1110.1NTS, CCK, PYY
27isoproterenol44 1110.0PYY, SST, NTS
28phosphoramidon44 1110.0NTS, DPP4, CCK
29gnrh448.9NTS, SST, PYY
30carbon448.9CCK, DPP4, NTS
31benzodiazepine448.8NTS, CCK
32oxyntomodulin44 619.7PYY, SST, CCK, NTS
33amphetamine44 50 1110.7PYY, SST, CCK, NTS
34octreotide44 61 28 1111.7NTS, CCK, SST, PYY
35atropine44 28 1110.7PYY, SST, CCK, NTS
36carbachol44 28 1110.7PYY, SST, CCK, NTS
375-hydroxytryptamine448.7PYY, SST, CCK, NTS
38acth448.7PYY, SST, CCK, NTS
39gaba448.7PYY, SST, CCK, NTS
40norepinephrine44 24 1110.7NTS, CCK, SST, PYY
41histamine44 28 2410.7PYY, SST, CCK, NTS
42acetylcholine44 50 28 24 1112.7PYY, SST, CCK, NTS
43phenylalanine448.6FLNA, CCK, NTS
44adenylate448.5SST, CCK, DPP4, NTS
45arginine448.5NTS, CCK, SST, PYY
46glutamate448.3NTS, DPP4, CCK, SST
47c-peptide448.2NTS, DPP4, CCK, SST, PYY
48glucose448.1PYY, SST, CCK, DPP4, NTS
49dopamine44 28 24 1111.1PYY, FLNA, SST, CCK, NTS
50tyrosine447.8PYY, FLNA, CCK, DPP4, NTS

GO Terms for genes affiliated with Short Bowel Syndrome

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Cellular components related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6NTS, CCK, SST, FLNA, PYY

Biological processes related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:0075869.6SST, PYY
2eating behaviorGO:0427559.2CCK, PYY

Molecular functions related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1CCK, SST, PYY
2neuropeptide hormone activityGO:0051848.4NTS, CCK, PYY

Products for genes affiliated with Short Bowel Syndrome

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Sources for Short Bowel Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet