MCID: SHR001
MIFTS: 51

Short Bowel Syndrome malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Short Bowel Syndrome

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Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. the main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. examples of treatment include diet and nutritional support, and in some cases intestinal transplantation. last updated: 4/29/2011

MalaCards: Short Bowel Syndrome, also known as acquired short bowel syndrome, is related to intestinal pseudo-obstruction and diarrhea. An important gene associated with Short Bowel Syndrome is CLMP (CXADR-like membrane protein), and among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. The compounds enterogastrone and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are growth/size/body and nervous system.

Wikipedia:65 Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder... more...

Aliases & Classifications for Short Bowel Syndrome

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

short bowel syndrome 8 43 10 45 62
acquired short bowel syndrome 8
short gut syndrome 8


External Ids:

Disease Ontology8 DOID:10605
MeSH35 D012778

Related Diseases for Short Bowel Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Short Bowel Syndrome:



Diseases related to short bowel syndrome

Symptoms for Short Bowel Syndrome

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Drugs & Therapeutics for Short Bowel Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Short Bowel Syndrome

Search NIH Clinical Center for Short Bowel Syndrome

Genetic Tests for Short Bowel Syndrome

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Anatomical Context for Short Bowel Syndrome

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Sources:
33MalaCards
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MalaCards organs/tissues related to Short Bowel Syndrome:

33
Small intestine, Liver, Colon, Bone, Skin, Breast, Thyroid, Heart, Testes, Kidney, Pancreas

Animal Models for Short Bowel Syndrome or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Short Bowel Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.6NTS, DPP4, SST, FLNA, PYY
2MP:00036317.3PYY, FLNA, SST, CCK, NTS
3MP:00053767.0NTS, DPP4, CCK, SST, FLNA, PYY

Publications for Short Bowel Syndrome

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Sources:
52PubMed
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Articles related to Short Bowel Syndrome:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Persistent metabolic acidosis in a hemodialyzed patient with short bowel syndrome. (23774551)
2013
2
Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations. (23037936)
2013
3
Key issues in addressing the clinical and humanistic burden of short bowel syndrome in the US. (23480444)
2013
4
Study of teduglutide effectiveness in parenteral nutrition-dependent short-bowel syndrome subjects. (24134154)
2013
5
Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL) scale. (23274148)
2013
6
Vitamin K status in patients with short bowel syndrome. (22633417)
2012
7
Short bowel syndrome in children: current and potential therapies. (22452596)
2012
8
Intestinal rehabilitation and bowel reconstructive surgery: improved outcomes in children with short bowel syndrome? (22197947)
2012
9
Long-term nutritional assessment of patients with severe short bowel syndrome managed with home enteral nutrition and oral intake. (22470032)
2011
10
Plasma citrulline as marker of bowel adaptation in children with short bowel syndrome. (21630079)
2011
11
Intestinal lengthening in adult patients with short bowel syndrome. (20734155)
2010
12
The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. (20171649)
2010
13
Enteral nutrition in children with short-bowel syndrome: current evidence and recommendations for the clinician. (20184992)
2010
14
Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. (19179884)
2009
15
Non perianal fistulas in Crohn's disease and short bowel syndrome: what we can do? (20380119)
2009
16
Pediatric short-bowel syndrome: the cost of comprehensive care. (19064515)
2008
17
Growth and nutritional aspects of infantile short bowel syndrome for the past 2 decades. (18970941)
2008
18
Congenital short bowel syndrome: a case report and review of the literature. (18209785)
2008
19
Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome. (17307727)
2007
20
Autologous gastrointestinal reconstruction for short bowel syndrome. (17260708)
2007
21
Intestinal transplantation for short bowel syndrome and gastrointestinal failure: current consensus, rewarding outcomes, and practical guidelines. (16473061)
2006
22
Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome. (16710856)
2006
23
Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. (16244538)
2005
24
Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome. (15991189)
2005
25
Recurrent D-lactic acidosis in a child with short bowel syndrome. (15927940)
2005
26
Small bowel volvulus leading to gangrene and short bowel syndrome. (15670531)
2005
27
Treatment of restless legs syndrome with subcutaneous apomorphine in a patient with short bowel syndrome. (15726274)
2005
28
Dipeptidyl-peptidase IV in patients with short bowel syndrome. (16169633)
2005
29
Enteric-coated cholylsarcosine microgranules for the treatment of short bowel syndrome. (15638993)
2005
30
A useful experimental model of short bowel syndrome. (14761823)
2004
31
Surgical rehabilitation of intestine in short bowel syndrome. (15118580)
2004
32
A prospective within-patient comparison clinical trial on the effect of parenteral cimetidine for improvement of fluid secretion and electrolyte balance in patients with short bowel syndrome. (15532817)
2004
33
Intestinal rehabilitation and the short bowel syndrome: part 1. (15233682)
2004
34
Total parenteral nutrition, intestinal adaptation, and short bowel syndrome. (14990282)
2004
35
Fasting breath hydrogen concentration in short bowel syndrome patients with colon incontinuity before and after antibiotic therapy. (14962684)
2004
36
New and emerging therapies for short bowel syndrome in children. (12895135)
2003
37
Low-fat diet impairs postresection intestinal adaptation in a rat model of short bowel syndrome. (12891489)
2003
38
Indications for specific therapy in the rehabilitation of patients with the short-bowel syndrome. (14642856)
2003
39
Effects of enteral arginine supplementation on the structural intestinal adaptation in a rat model of short bowel syndrome. (12870793)
2003
40
Adverse effects of liver dysfunction and portal hypertension on intestinal adaptation in short bowel syndrome in children. (12488176)
2002
41
Does ileal reverse segment in rats with short bowel syndrome change intestinal morphology? (11840034)
2002
42
Effect of transforming growth factor-alpha on intestinal adaptation in a rat model of short bowel syndrome. (12505047)
2002
43
Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome. (11987081)
2002
44
Pharmacotherapy and growth factors in the treatment of short bowel syndrome. (11329609)
2001
45
Treatment of short-bowel syndrome. (11706294)
2001
46
Severe convulsant hypomagnesaemia and short bowel syndrome. (11439801)
2001
47
Combination therapy with Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides dramatically improved the intestinal function in a girl with short bowel syndrome: a novel synbiotics therapy for intestinal failure. (11575457)
2001
48
Intestinal ornithine decarboxylase in short bowel syndrome patients with oral diet. (11327746)
2001
49
Clinical use of growth hormone and glutamine in short bowel syndrome. (10488599)
1999
50
Warfarin resistance in a patient with short-bowel syndrome. (3614776)
1987

Variations for Short Bowel Syndrome

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Expression for genes affiliated with Short Bowel Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Short Bowel Syndrome

Search GEO for disease gene expression data for Short Bowel Syndrome.

Pathways for genes affiliated with Short Bowel Syndrome

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Short Bowel Syndrome

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1enterogastrone459.9CCK, PYY
2taurodeoxycholate459.9CCK, SST
3minigastrin459.9CCK, SST
4vapreotide45 29 1111.8CCK, SST
5alosetron45 1110.8CCK, SST
6glipizide45 51 1111.8SST, DPP4
7bethanechol45 29 1111.8CCK, SST
8rimonabant45 29 1111.7DPP4, CCK
9cyproheptadine45 29 1111.7SST, CCK
10orlistat45 61 1111.5CCK, PYY
11intralipid459.5PYY, SST, CCK
12pirenzepine45 29 1111.5CCK, SST
13omeprazole45 51 29 24 1113.5SST, CCK, PYY
14cyclo(his-pro)459.5CCK, NTS
15pramlintide45 1110.5DPP4, CCK, PYY
16incretin459.5CCK, PYY, DPP4
17enterostatin459.4NTS, CCK
18loperamide45 24 1111.4SST, CCK
19alpha msh459.4CCK, NTS
20carbohydrates459.3DPP4, CCK, PYY
21clonidine45 51 29 1112.2SST, PYY, NTS
22loxiglumide459.1CCK, SST, NTS
23dtpa459.1NTS, SST, CCK
24tetrodotoxin45 61 2911.1CCK, PYY, NTS
25naloxone45 29 51 1112.1NTS, CCK, SST
26cocaine45 1110.1PYY, CCK, NTS
27isoproterenol45 1110.0PYY, SST, NTS
28phosphoramidon45 1110.0NTS, DPP4, CCK
29gnrh458.9PYY, NTS, SST
30carbon458.9NTS, CCK, DPP4
31benzodiazepine458.8NTS, CCK
32oxyntomodulin45 619.7PYY, NTS, CCK, SST
33amphetamine45 51 1110.7SST, PYY, CCK, NTS
34octreotide45 61 29 1111.7CCK, SST, NTS, PYY
35atropine45 29 1110.7CCK, SST, NTS, PYY
36carbachol45 29 1110.7NTS, PYY, SST, CCK
375-hydroxytryptamine458.7SST, NTS, CCK, PYY
38acth458.7PYY, CCK, SST, NTS
39gaba458.7NTS, CCK, SST, PYY
40norepinephrine45 24 1110.7NTS, PYY, SST, CCK
41histamine45 29 2410.7NTS, PYY, SST, CCK
42acetylcholine45 51 29 24 1112.7NTS, PYY, CCK, SST
43phenylalanine458.6FLNA, NTS, CCK
44adenylate458.5CCK, NTS, SST, DPP4
45arginine458.5SST, PYY, CCK, NTS
46glutamate458.3NTS, DPP4, CCK, SST
47c-peptide458.2NTS, SST, DPP4, CCK, PYY
48glucose458.1SST, CCK, PYY, NTS, DPP4
49dopamine45 29 24 1111.1PYY, CCK, NTS, FLNA, SST
50tyrosine457.8PYY, FLNA, CCK, NTS, DPP4

GO Terms for genes affiliated with Short Bowel Syndrome

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16Gene Ontology
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Cellular components related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6NTS, CCK, SST, FLNA, PYY

Biological processes related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:0075869.6SST, PYY
2eating behaviorGO:0427559.2CCK, PYY

Molecular functions related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1CCK, SST, PYY
2neuropeptide hormone activityGO:0051848.4NTS, CCK, PYY

Products for genes affiliated with Short Bowel Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Short Bowel Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet