MCID: SHR001
MIFTS: 51

Short Bowel Syndrome malady

Rare diseases, Gastrointestinal diseases categories

Summaries for Short Bowel Syndrome

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Sources:
44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. the main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. examples of treatment include diet and nutritional support, and in some cases intestinal transplantation. last updated: 4/29/2011

MalaCards: Short Bowel Syndrome, also known as acquired short bowel syndrome, is related to intestinal pseudo-obstruction and diarrhea. An important gene associated with Short Bowel Syndrome is CLMP (CXADR-like membrane protein), and among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. The compounds enterogastrone and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are growth/size/body and nervous system.

Wikipedia:66 Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder... more...

Aliases & Classifications for Short Bowel Syndrome

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

short bowel syndrome 9 44 11 46 63
acquired short bowel syndrome 9
short gut syndrome 9


External Ids:

Disease Ontology9 DOID:10605
MeSH36 D012778

Related Diseases for Short Bowel Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Short Bowel Syndrome:



Diseases related to short bowel syndrome

Symptoms for Short Bowel Syndrome

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Drugs & Therapeutics for Short Bowel Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Short Bowel Syndrome

Drug clinical trials:

Search ClinicalTrials for Short Bowel Syndrome

Search NIH Clinical Center for Short Bowel Syndrome

Search CenterWatch for Short Bowel Syndrome

Genetic Tests for Short Bowel Syndrome

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Anatomical Context for Short Bowel Syndrome

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Sources:
34MalaCards
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MalaCards organs/tissues related to Short Bowel Syndrome:

34
Small intestine, Liver, Colon, Bone, Skin, Breast, Thyroid, Heart, Testes, Kidney, Pancreas

Animal Models for Short Bowel Syndrome or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Short Bowel Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.6NTS, DPP4, SST, FLNA, PYY
2MP:00036317.3PYY, FLNA, SST, CCK, NTS
3MP:00053767.0NTS, DPP4, CCK, SST, FLNA, PYY

Publications for Short Bowel Syndrome

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Sources:
53PubMed
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Articles related to Short Bowel Syndrome:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Persistent metabolic acidosis in a hemodialyzed patient with short bowel syndrome. (23774551)
2013
2
Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations. (23037936)
2013
3
Key issues in addressing the clinical and humanistic burden of short bowel syndrome in the US. (23480444)
2013
4
Study of teduglutide effectiveness in parenteral nutrition-dependent short-bowel syndrome subjects. (24134154)
2013
5
Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL) scale. (23274148)
2013
6
Vitamin K status in patients with short bowel syndrome. (22633417)
2012
7
Short bowel syndrome in children: current and potential therapies. (22452596)
2012
8
Intestinal rehabilitation and bowel reconstructive surgery: improved outcomes in children with short bowel syndrome? (22197947)
2012
9
Long-term nutritional assessment of patients with severe short bowel syndrome managed with home enteral nutrition and oral intake. (22470032)
2011
10
Plasma citrulline as marker of bowel adaptation in children with short bowel syndrome. (21630079)
2011
11
Intestinal lengthening in adult patients with short bowel syndrome. (20734155)
2010
12
The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. (20171649)
2010
13
Enteral nutrition in children with short-bowel syndrome: current evidence and recommendations for the clinician. (20184992)
2010
14
Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. (19179884)
2009
15
Non perianal fistulas in Crohn's disease and short bowel syndrome: what we can do? (20380119)
2009
16
Pediatric short-bowel syndrome: the cost of comprehensive care. (19064515)
2008
17
Growth and nutritional aspects of infantile short bowel syndrome for the past 2 decades. (18970941)
2008
18
Congenital short bowel syndrome: a case report and review of the literature. (18209785)
2008
19
Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome. (17307727)
2007
20
Autologous gastrointestinal reconstruction for short bowel syndrome. (17260708)
2007
21
Intestinal transplantation for short bowel syndrome and gastrointestinal failure: current consensus, rewarding outcomes, and practical guidelines. (16473061)
2006
22
Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome. (16710856)
2006
23
Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. (16244538)
2005
24
Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome. (15991189)
2005
25
Recurrent D-lactic acidosis in a child with short bowel syndrome. (15927940)
2005
26
Small bowel volvulus leading to gangrene and short bowel syndrome. (15670531)
2005
27
Treatment of restless legs syndrome with subcutaneous apomorphine in a patient with short bowel syndrome. (15726274)
2005
28
Dipeptidyl-peptidase IV in patients with short bowel syndrome. (16169633)
2005
29
Enteric-coated cholylsarcosine microgranules for the treatment of short bowel syndrome. (15638993)
2005
30
A useful experimental model of short bowel syndrome. (14761823)
2004
31
Surgical rehabilitation of intestine in short bowel syndrome. (15118580)
2004
32
A prospective within-patient comparison clinical trial on the effect of parenteral cimetidine for improvement of fluid secretion and electrolyte balance in patients with short bowel syndrome. (15532817)
2004
33
Intestinal rehabilitation and the short bowel syndrome: part 1. (15233682)
2004
34
Total parenteral nutrition, intestinal adaptation, and short bowel syndrome. (14990282)
2004
35
Fasting breath hydrogen concentration in short bowel syndrome patients with colon incontinuity before and after antibiotic therapy. (14962684)
2004
36
New and emerging therapies for short bowel syndrome in children. (12895135)
2003
37
Low-fat diet impairs postresection intestinal adaptation in a rat model of short bowel syndrome. (12891489)
2003
38
Indications for specific therapy in the rehabilitation of patients with the short-bowel syndrome. (14642856)
2003
39
Effects of enteral arginine supplementation on the structural intestinal adaptation in a rat model of short bowel syndrome. (12870793)
2003
40
Adverse effects of liver dysfunction and portal hypertension on intestinal adaptation in short bowel syndrome in children. (12488176)
2002
41
Does ileal reverse segment in rats with short bowel syndrome change intestinal morphology? (11840034)
2002
42
Effect of transforming growth factor-alpha on intestinal adaptation in a rat model of short bowel syndrome. (12505047)
2002
43
Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome. (11987081)
2002
44
Pharmacotherapy and growth factors in the treatment of short bowel syndrome. (11329609)
2001
45
Treatment of short-bowel syndrome. (11706294)
2001
46
Severe convulsant hypomagnesaemia and short bowel syndrome. (11439801)
2001
47
Combination therapy with Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides dramatically improved the intestinal function in a girl with short bowel syndrome: a novel synbiotics therapy for intestinal failure. (11575457)
2001
48
Intestinal ornithine decarboxylase in short bowel syndrome patients with oral diet. (11327746)
2001
49
Clinical use of growth hormone and glutamine in short bowel syndrome. (10488599)
1999
50
Warfarin resistance in a patient with short-bowel syndrome. (3614776)
1987

Variations for Short Bowel Syndrome

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Expression for genes affiliated with Short Bowel Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Short Bowel Syndrome

Search GEO for disease gene expression data for Short Bowel Syndrome.

Pathways for genes affiliated with Short Bowel Syndrome

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Short Bowel Syndrome

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1enterogastrone469.9CCK, PYY
2taurodeoxycholate469.9CCK, SST
3minigastrin469.9CCK, SST
4vapreotide46 30 1211.8CCK, SST
5alosetron46 1210.8CCK, SST
6glipizide46 52 1211.8SST, DPP4
7bethanechol46 30 1211.8CCK, SST
8rimonabant46 30 1211.7DPP4, CCK
9cyproheptadine46 30 1211.7SST, CCK
10orlistat46 62 1211.5CCK, PYY
11intralipid469.5PYY, SST, CCK
12pirenzepine46 30 1211.5CCK, SST
13omeprazole46 52 30 25 1213.5SST, CCK, PYY
14cyclo(his-pro)469.5CCK, NTS
15pramlintide46 1210.5DPP4, CCK, PYY
16incretin469.5CCK, PYY, DPP4
17enterostatin469.4NTS, CCK
18loperamide46 25 1211.4SST, CCK
19alpha msh469.4CCK, NTS
20carbohydrates469.3DPP4, CCK, PYY
21clonidine46 52 30 1212.2SST, PYY, NTS
22loxiglumide469.1CCK, SST, NTS
23dtpa469.1NTS, SST, CCK
24tetrodotoxin46 62 3011.1CCK, PYY, NTS
25naloxone46 30 52 1212.1NTS, CCK, SST
26cocaine46 1210.1PYY, CCK, NTS
27isoproterenol46 1210.0PYY, SST, NTS
28phosphoramidon46 1210.0NTS, DPP4, CCK
29gnrh468.9PYY, NTS, SST
30carbon468.9NTS, CCK, DPP4
31benzodiazepine468.8NTS, CCK
32oxyntomodulin46 629.7PYY, NTS, CCK, SST
33amphetamine46 52 1210.7SST, PYY, CCK, NTS
34octreotide46 62 30 1211.7CCK, SST, NTS, PYY
35atropine46 30 1210.7CCK, SST, NTS, PYY
36carbachol46 30 1210.7NTS, PYY, SST, CCK
375-hydroxytryptamine468.7SST, NTS, CCK, PYY
38acth468.7PYY, CCK, SST, NTS
39gaba468.7NTS, CCK, SST, PYY
40norepinephrine46 25 1210.7NTS, PYY, SST, CCK
41histamine46 30 2510.7NTS, PYY, SST, CCK
42acetylcholine46 52 30 25 1212.7NTS, PYY, CCK, SST
43phenylalanine468.6FLNA, NTS, CCK
44adenylate468.5CCK, NTS, SST, DPP4
45arginine468.5SST, PYY, CCK, NTS
46glutamate468.3NTS, DPP4, CCK, SST
47c-peptide468.2NTS, SST, DPP4, CCK, PYY
48glucose468.1SST, CCK, PYY, NTS, DPP4
49dopamine46 30 25 1211.1PYY, CCK, NTS, FLNA, SST
50tyrosine467.8PYY, FLNA, CCK, NTS, DPP4

GO Terms for genes affiliated with Short Bowel Syndrome

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17Gene Ontology
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Cellular components related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.6NTS, CCK, SST, FLNA, PYY

Biological processes related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:0075869.6SST, PYY
2eating behaviorGO:0427559.2CCK, PYY

Molecular functions related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1CCK, SST, PYY
2neuropeptide hormone activityGO:0051848.4NTS, CCK, PYY

Products for genes affiliated with Short Bowel Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Short Bowel Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet