MCID: SHR001
MIFTS: 49

Short Bowel Syndrome malady

Categories: Rare diseases, Gastrointestinal diseases, Genetic diseases, Fetal diseases

Aliases & Classifications for Short Bowel Syndrome

Aliases & Descriptions for Short Bowel Syndrome:

Name: Short Bowel Syndrome 12 50 52 42 14 69
Acquired Short Bowel Syndrome 12
Short Gut Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10605
MeSH 42 D012778
NCIt 47 C99059
UMLS 69 C0036992

Summaries for Short Bowel Syndrome

NIH Rare Diseases : 50 short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. the main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. examples of treatment include diet and nutritional support, and in some cases intestinal transplantation. last updated: 4/29/2011

MalaCards based summary : Short Bowel Syndrome, also known as acquired short bowel syndrome, is related to congenital short bowel syndrome and secondary short bowel syndrome, and has symptoms including pain, postoperative and postoperative nausea and vomiting. An important gene associated with Short Bowel Syndrome is CLMP (CXADR Like Membrane Protein), and among its related pathways/superpathways are Signaling by GPCR and Focal Adhesion. The drugs Esomeprazole and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and kidney, and related phenotype is growth/size/body region.

Wikipedia : 71 Short bowel syndrome (SBS, or simply short gut) is a malabsorption disorder caused by a lack of... more...

Related Diseases for Short Bowel Syndrome

Diseases in the Short Bowel Syndrome family:

Congenital Short Bowel Syndrome Secondary Short Bowel Syndrome

Diseases related to Short Bowel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 congenital short bowel syndrome 12.3
2 secondary short bowel syndrome 11.8
3 intestinal pseudoobstruction, neuronal 11.5
4 gastroschisis 11.1
5 intestinal pseudo-obstruction 10.8
6 partial optic atrophy 10.3 FLNA GCG
7 al-raqad syndrome 10.3 CLMP FLNA
8 paranasal sinus cancer, adult 10.2 NTS SST
9 vaginal adenoma 10.2 IGF1 SST
10 volkmann contracture 10.2 NTS SST
11 adult botryoid rhabdomyosarcoma 10.1 NTS SST
12 uterine ligament cancer 10.1 IGF1 SST
13 liver disease 10.1
14 progressive relapsing multiple sclerosis 10.1 NTS SST
15 maturity-onset diabetes of the young, type 13 10.1 GCG SST
16 pituitary adenoma, acth-secreting 10.1 IGF1 SST
17 protein s deficiency 10.1 IGF1 SST
18 myocardial stunning 10.1 CCK SST
19 choline deficiency disease 10.1 NTS PYY SST
20 neurogenic arthropathy 10.1 GCG IGF1 SST
21 adrenal adenoma 10.0 GCG IGF1 PYY
22 peroneal neuropathy 10.0 GCG IGF1 SST
23 body dysmorphic disorder 10.0 GCG IGF1 SST
24 gemistocytic astrocytoma 10.0 CCK GCG SST
25 brain stem glioma 10.0 GCG IGF1 SST
26 deafness, autosomal recessive 74 10.0 EGF IGF1
27 mucopolysaccharidosis iii 10.0 CCK GCG PYY
28 eccrine papillary adenocarcinoma 10.0 GCG SST
29 lactic acidosis 10.0
30 adult brain stem glioma 10.0 CCK NTS
31 peripheral degeneration of cornea 10.0 GCG NTS PYY SST
32 hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10.0 CCK NTS PYY
33 endocrine gland cancer 10.0 CCK NTS SST
34 edict syndrome 9.9 EGF IGF1 SST
35 scleral staphyloma 9.9 CCK SST
36 crohn's disease 9.9
37 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 9.9 CCK IGF1 PYY
38 cardioauditory syndrome of sanchez cascos 9.9 IGF1 NTS PYY SST
39 childhood malignant hemangiopericytoma 9.9 CCK GCG PYY SST
40 epidermolysis bullosa simplex, sutosomal recessive 2 9.9 HGF IGF1 SST
41 diarrhea 9.8
42 tricuspid valve stenosis 9.8 CCK NTS PYY SST
43 chondroma 9.8 CCK GCG IGF1 SST
44 cholestasis 9.8
45 mucositis 9.8
46 encephalopathy 9.8
47 sweat gland cancer 9.7 CCK FLNA NTS PYY SST
48 xerophthalmia 9.7
49 intestinal atresia 9.7
50 hypokalemia 9.7

Graphical network of the top 20 diseases related to Short Bowel Syndrome:



Diseases related to Short Bowel Syndrome

Symptoms & Phenotypes for Short Bowel Syndrome

UMLS symptoms related to Short Bowel Syndrome:


pain, postoperative, postoperative nausea and vomiting

MGI Mouse Phenotypes related to Short Bowel Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.23 CLMP EGF FLNA HGF IGF1 NTS

Drugs & Therapeutics for Short Bowel Syndrome

Drugs for Short Bowel Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 260)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
2
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
3
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
4
Lactulose Approved Phase 4 4618-18-2 11333
5
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
6
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
7
Norepinephrine Approved Phase 4 51-41-2 439260
8
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
9 Antacids Phase 4
10 Anti-Ulcer Agents Phase 4
11 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
12
Proton pump inhibitors Phase 4,Phase 2
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2
15 Erythromycin Estolate Phase 4
16 Erythromycin Ethylsuccinate Phase 4
17 Erythromycin stearate Phase 4
18 glucagon Phase 4,Phase 1,Phase 2
19 Glucagon-Like Peptide 1 Phase 4,Phase 1,Phase 2
20
Bilirubin Phase 4,Phase 2 635-65-4 5280352
21 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
22 Hormones Phase 4,Phase 3,Phase 2,Phase 1
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
24 Liver Extracts Phase 4,Phase 2,Phase 3,Phase 1
25 N-Methylaspartate Phase 4,Phase 2
26 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
27 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
28 HIV Protease Inhibitors Phase 4,Phase 2
29
protease inhibitors Phase 4,Phase 2
30 Fat Emulsions, Intravenous Phase 4,Phase 2,Phase 1
31 Parenteral Nutrition Solutions Phase 4,Phase 2,Phase 1
32 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
33 Soybean oil, phospholipid emulsion Phase 4,Phase 2,Phase 1
34 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
35 Incretins Phase 4,Phase 1,Phase 2
36 Cholagogues and Choleretics Phase 4
37 Analgesics Phase 4,Phase 3,Phase 1
38 Antidepressive Agents Phase 4
39 Dopamine Agents Phase 4
40 Duloxetine Hydrochloride Phase 4
41 Neurotransmitter Uptake Inhibitors Phase 4
42 Psychotropic Drugs Phase 4
43
Serotonin Phase 4 50-67-9 5202
44 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
45 Caseins Phase 4
46 Chelating Agents Phase 4
47 Anticonvulsants Phase 4,Early Phase 1
48 GABA Agents Phase 4,Early Phase 1
49 Dipeptidyl-Peptidase IV Inhibitors Phase 4
50 Hypoglycemic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 175)
id Name Status NCT ID Phase
1 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
2 Gastric Functions & Proton Pump Inhibitor( PPI) Study Unknown status NCT00951431 Phase 4
3 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4
4 Short Bowel Syndrome and Teduglutide Versus Placebo Completed NCT02099084 Phase 4
5 The Preventative and Therapeutical Effect of Ursodeoxycholic Acid(UDCA) to Short Bowel Syndrome Patients Completed NCT01974336 Phase 4
6 rHGH and Intestinal Permeability in Intestinal Failure Completed NCT01380366 Phase 4
7 An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome Completed NCT00401258 Phase 4
8 Effects Comparison of A1 and A2 Milk on Gastrointestinal Physiology, Symptoms and Cognitive Behavior Completed NCT02406469 Phase 4
9 The Use of DPP-4 Inhibitors in Short Bowel Syndrome Recruiting NCT02653131 Phase 4
10 rtPA in in the Prevention of CVAD-Associated Thrombosis and Infection in Pediatric Patients With Short Bowel Syndrome Recruiting NCT02355743 Phase 4
11 SMOFLipid in Intralipid Intolerant Recruiting NCT03054948 Phase 4
12 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version Not yet recruiting NCT02354560 Phase 4
13 Evaluate the Efficacy and Safety Growth Hormone, Glutamine and Diet in Patients With Short Bowel Syndrome (SBS) Terminated NCT00742157 Phase 4
14 Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion Terminated NCT02476994 Phase 4
15 Efficacy of Gralise® for Chronic Pelvic Pain Terminated NCT01678911 Phase 4
16 Exenatide on GI Motor Function and Permeability in Short Bowel Syndrome Withdrawn NCT01818648 Phase 4
17 Evaluation of the Efficacy and Safety of Recombinant Human Growth Hormone (rhGH) in the Treatment of Children With Short Bowel Syndrome Completed NCT00169637 Phase 3
18 Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome Completed NCT00081458 Phase 3
19 Study of Teduglutide Effectiveness in Parenteral Nutrition (PN)-Dependent Short Bowel Syndrome (SBS) Subjects Completed NCT00798967 Phase 3
20 A Pharmacokinetic, Safety, and Pharmacodynamic Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome Completed NCT01952080 Phase 3
21 Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome Who Completed Protocol CL0600-004 (NCT00081458) Completed NCT00172185 Phase 3
22 Open-Label Study of Teduglutide for Subjects With PN-Dependent Short Bowel Syndrome (SBS) Completed NCT00930644 Phase 3
23 A One-Year, Open-Label Study With Teduglutide for Subjects Who Completed Study CL0600-021 Completed NCT01560403 Phase 3
24 Impact of SPN on Infection Rate, Duration of Mechanical Ventilation & Rehabilitation in ICU Patients Completed NCT00802503 Phase 3
25 Nursing Management of Irritable Bowel Syndrome:Improving Outcomes Completed NCT00167635 Phase 2, Phase 3
26 Efficacy of Transcranial Magnetic Stimulation (TMS) in Chronic Idiopathic Pain Disorders Completed NCT00374673 Phase 3
27 Lanreotide Autogel in the Symptomatic Treatment of Refractory Diarrhea Completed NCT00891371 Phase 2, Phase 3
28 Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients Completed NCT01045837 Phase 2, Phase 3
29 A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's Disease Completed NCT01243671 Phase 3
30 Telotristat Etiprate for Carcinoid Syndrome Therapy Completed NCT02063659 Phase 3
31 HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease Completed NCT01100099 Phase 2, Phase 3
32 Gastrointestinal Biopsychosocial Research Center Completed NCT00947180 Phase 3
33 Long-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome (SBS) Who Completed TED-C14-006 Recruiting NCT02954458 Phase 3
34 Long-term Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome Who Completed the TED-C13-003 Study Recruiting NCT02949362 Phase 3
35 Study in Japanese Pediatric Subjects With Short Bowel Syndrome (SBS) Who Are Dependent on Parenteral Support Recruiting NCT02980666 Phase 3
36 Safety and Efficacy Study in Infant With SBS Recruiting NCT02865122 Phase 2, Phase 3
37 Cholestasis Reversal: Efficacy of IV Fish Oil Recruiting NCT00910104 Phase 2, Phase 3
38 Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and Children Recruiting NCT01194063 Phase 3
39 The Effects of Butyrate on Children With Obesity Recruiting NCT02721953 Phase 2, Phase 3
40 Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae Recruiting NCT02795949 Phase 3
41 Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition Active, not recruiting NCT02682381 Phase 3
42 Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Teduglutide in Japanese Subjects With PN-dependent Short Bowel Syndrome (SBS) Active, not recruiting NCT02340819 Phase 3
43 Self Administered Cognitive Behavior Therapy for Irritable Bowel Syndrome Active, not recruiting NCT00738920 Phase 2, Phase 3
44 Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis Not yet recruiting NCT02976688 Phase 2, Phase 3
45 Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded Cross-over Study Terminated NCT02266849 Phase 3
46 A Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Investigational Product MP-101 in Subjects With Short Bowel Syndrome Who Have Had an Inadequate Response to Anti-Diarrheals Withdrawn NCT02242656 Phase 3
47 A Open Label Extension Study for Subjects That Complete Study MP-101-CL-001 Withdrawn NCT02246816 Phase 3
48 Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome Unknown status NCT01263574 Phase 2
49 Investigational Study of Oral Fish Oil in Treating Parenteral Nutrition Associated Liver Disease Unknown status NCT01191177 Phase 1, Phase 2
50 Efficacy and Safety of Omega-3 Lipid Therapy in Pediatric Patients With Parenteral Nutrition-Associated Liver Disease Unknown status NCT01739517 Phase 2

Search NIH Clinical Center for Short Bowel Syndrome

Cochrane evidence based reviews: short bowel syndrome

Genetic Tests for Short Bowel Syndrome

Anatomical Context for Short Bowel Syndrome

MalaCards organs/tissues related to Short Bowel Syndrome:

39
Small Intestine, Liver, Kidney, Colon, Bone, Skin, Heart

Publications for Short Bowel Syndrome

Articles related to Short Bowel Syndrome:

(show top 50) (show all 626)
id Title Authors Year
1
Teduglutide and Intestinal Permeability in Short Bowel Syndrome. ( 27875268 )
2016
2
Two new mutations of the CLMP gene identified in a newborn presenting congenital short-bowel syndrome. ( 27720179 )
2016
3
Management of short bowel syndrome in postoperative very low birth weight infants. ( 27576105 )
2016
4
Differential Effects on Intestinal Adaptation Following Exogenous Glucagon-Like Peptide 2 Therapy With and Without Enteral Nutrition in Neonatal Short Bowel Syndrome. ( 27660290 )
2016
5
Intestinal microbiota in adult patients with Short Bowel Syndrome: Preliminary results from a pilot study. ( 27729172 )
2016
6
Surgical management and autologous intestinal reconstruction in short bowel syndrome. ( 27086890 )
2016
7
Inhibition of Fgf signaling in short bowel syndrome increases weight loss and epithelial proliferation. ( 27771159 )
2016
8
Bioelectrical impedance vector analysis as a useful predictor of nutritional status in patients with short bowel syndrome. ( 27491548 )
2016
9
The impact of intestinal resection on the immune function of short bowel syndrome patients. ( 27486135 )
2016
10
Definitions of intestinal failure and the short bowel syndrome. ( 27086884 )
2016
11
Necrotizing enterocolitis is associated with earlier achievement of enteral autonomy in children with short bowel syndrome. ( 26700691 )
2016
12
Closed gastroschisis, vanishing midgut and extreme short bowel syndrome: Case report and review of the literature. ( 27867410 )
2016
13
Effect of sildenafil on intestinal adaptation parameters in a rat model of short bowel syndrome. ( 26914129 )
2016
14
Is jejunostomy output nutrient or waste in short bowel syndrome? Experience from six cases. ( 27222428 )
2016
15
Outcomes from a 12-Week, Open-Label, Multicenter Clinical Trial of Teduglutide in Pediatric Short Bowel Syndrome. ( 27855998 )
2016
16
Genetic screening of Congenital Short Bowel Syndrome patients confirms CLMP as the major gene involved in the recessive form of this disorder. ( 27352967 )
2016
17
Treatment of short bowel syndrome in children. Value of the Intestinal Rehabilitation Program. ( 27849236 )
2016
18
High Prevalence of Suboptimal Vitamin D Status and Bone Loss in Adult Short Bowel Syndrome Even After Weaning Off Parenteral Nutrition. ( 27589260 )
2016
19
Therapeutic Drug Monitoring of Anti-human Immunodeficiency Virus Drugs in a Patient with Short Bowel Syndrome. ( 27746450 )
2016
20
The administration of ghrelin improved hepatocellular injury following parenteral feeding in a rat model of short bowel syndrome. ( 27651372 )
2016
21
Short Bowel Syndrome and Intestinal Failure in Crohn's Disease. ( 26818425 )
2016
22
Draft Genome Sequence of Lactobacillus delbrueckii Strain #22 Isolated from a Patient with Short Bowel Syndrome and Previous d-Lactic Acidosis and Encephalopathy. ( 27469967 )
2016
23
Surgical strategies in short bowel syndrome. ( 28039510 )
2016
24
Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome. ( 27323884 )
2016
25
Long-Term Teduglutide for the Treatment of Patients With Intestinal Failure Associated With Short Bowel Syndrome. ( 26844839 )
2016
26
On the horizon: trophic peptide growth factors as therapy for neonatal short bowel syndrome. ( 26810694 )
2016
27
Safety and Efficacy of Teduglutide (Gattex) in Patients With Crohn's Disease and Need for Parenteral Support Due to Short Bowel Syndrome-associated Intestinal Failure. ( 27433811 )
2016
28
Heart rate control with oral metoprolol in a patient with Short Bowel Syndrome. ( 27625165 )
2016
29
Small Bowel Dilatation Predicts Prolonged Parenteral Nutrition and Decreased Survival in Pediatric Short Bowel Syndrome. ( 27433892 )
2016
30
Parenteral nutrition in short bowel syndrome patients, regardless of its duration, increases serum proinflammatory cytokines. ( 27267135 )
2016
31
Black pepper: Stimulation of diarrhea in patient with underlying short bowel syndrome. ( 27143806 )
2016
32
Independence From Parenteral Nutrition and Intravenous Fluid Support During Treatment With Teduglutide Among Patients With Intestinal Failure Associated With Short Bowel Syndrome. ( 27875291 )
2016
33
Apo AIV and Citrulline Plasma Concentrations in Short Bowel Syndrome Patients: The Influence of Short Bowel Anatomy. ( 27689355 )
2016
34
Small Bowel Diameter in Short Bowel Syndrome as a Predictive Factor for Achieving Enteral Autonomy. ( 27587075 )
2016
35
Severe Gut Microbiota Dysbiosis Is Associated With Poor Growth in Patients With Short Bowel Syndrome. ( 27406942 )
2016
36
Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome. ( 27037739 )
2016
37
Effect of Liraglutide Treatment on Jejunostomy Output in Patients With Short Bowel Syndrome: An Open-Label Pilot Study. ( 27875281 )
2016
38
Congenital Short Bowel Syndrome due to Absent Midgut. ( 27150813 )
2016
39
Redefining Short Bowel Syndrome in the 21st Century. ( 27997531 )
2016
40
A potential anatomic subtype of short bowel syndrome: a matched case-control study. ( 26822147 )
2016
41
Management and Complications of Short Bowel Syndrome: an Updated Review. ( 27324885 )
2016
42
Assessment of energy requirements in patients with short bowel syndrome by using the doubly labeled water method. ( 26675764 )
2016
43
Improvement in Parenteral Nutrition-Associated Cholestasis With the Use of Omegaven in an Infant With Short Bowel Syndrome. ( 27143651 )
2016
44
Accuracy of radiographic estimation of small bowel dimensions in pediatric patients with short bowel syndrome. ( 26995513 )
2016
45
Generation of an artificial intestine for the management of short bowel syndrome. ( 26867049 )
2016
46
Crystalline cardiomyopathy due to secondary oxalosis after short-bowel syndrome and end-stage renal failure. ( 27008641 )
2016
47
Extensive Intestinal Resection Triggers Behavioral Adaptation, Intestinal Remodeling and Microbiota Transition in Short Bowel Syndrome. ( 27681910 )
2016
48
Surgical Rehabilitation Techniques in Children with Poor Prognosis Short Bowel Syndrome. ( 26535775 )
2015
49
Congenital Short Bowel Syndrome: from clinical and genetic diagnosis to the molecular mechanisms involved in intestinal elongation. ( 26282049 )
2015
50
Disruptions of the intestinal microbiome in necrotizing enterocolitis, short bowel syndrome, and Hirschsprung's associated enterocolitis. ( 26528281 )
2015

Variations for Short Bowel Syndrome

Expression for Short Bowel Syndrome

Search GEO for disease gene expression data for Short Bowel Syndrome.

Pathways for Short Bowel Syndrome

GO Terms for Short Bowel Syndrome

Cellular components related to Short Bowel Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CCK EGF GCG HGF IGF1 PYY
2 platelet alpha granule lumen GO:0031093 9.33 EGF HGF IGF1
3 extracellular region GO:0005576 9.28 CCK EGF FLNA GCG HGF IGF1

Biological processes related to Short Bowel Syndrome according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.78 FLNA GCG HGF IGF1
2 positive regulation of cell proliferation GO:0008284 9.76 CCK EGF HGF IGF1
3 cell proliferation GO:0008283 9.71 GCG HGF IGF1 PYY
4 feeding behavior GO:0007631 9.56 GCG PYY
5 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.55 EGF GCG
6 eating behavior GO:0042755 9.54 CCK PYY
7 phosphatidylinositol-mediated signaling GO:0048015 9.54 EGF HGF IGF1
8 positive regulation of DNA binding GO:0043388 9.52 EGF IGF1
9 ERK1 and ERK2 cascade GO:0070371 9.51 EGF IGF1
10 activation of MAPK activity GO:0000187 9.5 EGF HGF IGF1
11 positive regulation of mitotic nuclear division GO:0045840 9.49 EGF IGF1
12 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.43 HGF IGF1
13 digestion GO:0007586 9.43 PYY SLC15A1 SST
14 platelet degranulation GO:0002576 9.26 EGF FLNA HGF IGF1
15 myoblast proliferation GO:0051450 9.16 HGF IGF1
16 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.92 CCK EGF HGF IGF1

Molecular functions related to Short Bowel Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 EGF HGF IGF1
2 neuropeptide hormone activity GO:0005184 9.13 CCK NTS PYY
3 hormone activity GO:0005179 9.02 CCK GCG IGF1 PYY SST

Sources for Short Bowel Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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