MCID: SHR001
MIFTS: 55

Short Bowel Syndrome malady

Gastrointestinal diseases category

Summaries for Short Bowel Syndrome

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. the main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. examples of treatment include diet and nutritional support, and in some cases intestinal transplantation. last updated: 4/29/2011

MalaCards: Short Bowel Syndrome, also known as acquired short bowel syndrome, is related to diarrhea and cholestasis. An important gene associated with Short Bowel Syndrome is PYY (peptide YY), and among its related pathways are Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) and Sodium/Proton exchangers. The compounds estradiol and pge2 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Wikipedia:63 Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder... more...

Aliases & Classifications for Short Bowel Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

short bowel syndrome 8 42 10 44 60
acquired short bowel syndrome 8
short gut syndrome 8


External Ids:

Disease Ontology8 DOID:10605
MeSH34 D012778

Related Diseases for Short Bowel Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Short Bowel Syndrome:



Diseases related to short bowel syndrome

Clinical Features for Short Bowel Syndrome

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Drugs & Therapeutics for Short Bowel Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Short Bowel Syndrome

Drug clinical trials:

Search ClinicalTrials for Short Bowel Syndrome

Search NIH Clinical Center for Short Bowel Syndrome

Search CenterWatch for Short Bowel Syndrome

Genetic Tests for Short Bowel Syndrome

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Anatomical Context for Short Bowel Syndrome

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32MalaCards
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MalaCards organs/tissues related to Short Bowel Syndrome:

32
Small intestine, Liver, Colon, Bone, Skin, Kidney, Heart, Pancreas, Thyroid, Breast, Testes

Animal Models for Short Bowel Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Short Bowel Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.0CCK, GLP2R, SLC5A2, NTS
2MP:00053819.6SLC15A1, SLC9A2, SLC9A3, GLP2R, EGF
3MP:00053759.6GH1, NTS, PYY, GLP2R, SLC5A2
4MP:00053799.2SLC9A3, GCG, PTH, HPN, GLP2R, DPP4
5MP:00053788.8GCG, SLC5A2, ABCB7, HPN, GLP2R, DPP4
6MP:00053768.6SLC5A2, CCK, GH1, NTS, SST, FGF7

Publications for Short Bowel Syndrome

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50PubMed
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Articles related to Short Bowel Syndrome:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Short bowel syndrome causing bleeding diathesis and profound vitamin deficiency in pregnancy. (23344400)
2013
2
Short Bowel Syndrome: Highlights of Patient Management, Quality of Life, and Survival. (24247092)
2013
3
Reconstruction of short bowel syndrome after internal hernia in a pregnant woman with previous bariatric surgery. (24240078)
2013
4
Increased intestinal absorption in the era of teduglutide and its impact on management strategies in patients with short bowel syndrome-associated intestinal failure. (23343999)
2013
5
Teduglutide injection (Gattex) for short bowel syndrome. (23588102)
2013
6
Long-term outcomes of isolated liver transplantation for short bowel syndrome and intestinal failure-associated liver disease. (22167020)
2012
7
Twelve-year-old female with short bowel syndrome presents with dizziness and confusion. (22418655)
2012
8
Long-term nutritional assessment of patients with severe short bowel syndrome managed with home enteral nutrition and oral intake. (22470032)
2011
9
Short- and long-term effects of small bowel resection: a unique histological study in a piglet model of short bowel syndrome. (21249379)
2011
10
Severe osteomalacia caused by short bowel syndrome in a patient on long-term hemodialysis after parathyroidectomy. (21069547)
2011
11
Intestinal lengthening in adult patients with short bowel syndrome. (20734155)
2010
12
Clinical trial simulations in pediatric patients using realistic covariates: application to teduglutide, a glucagon-like peptide-2 analog in neonates and infants with short-bowel syndrome. (19847163)
2009
13
Use of an ethanol lock to prevent catheter-related infections in children with short bowel syndrome. (18558177)
2008
14
Effect of lactulose on bacterial translocation and intestinal adaptation in a rat model of short bowel syndrome. (18493204)
2008
15
Comparison of short bowel syndrome acquired early in life and during adolescence. (18622279)
2008
16
Advantages of the distal sigmoid colostomy in the management of infants with short bowel syndrome. (18675636)
2008
17
The use of conjugated hyperbilirubinemia greater than 100 micromol/L as an indicator of irreversible liver disease in infants with short bowel syndrome. (17270549)
2007
18
Pediatric short bowel syndrome: adaptation after massive small bowel resection. (17667718)
2007
19
Jonathan E Rhoads lecture: experiences and observations in the management of patients with short bowel syndrome. (17595444)
2007
20
Possible effect of probiotics and breast milk in short bowel syndrome: report of one case. (17626609)
2007
21
The STEP procedure: defining its role in the management of pediatric short bowel syndrome. (17667710)
2007
22
Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study. (16923232)
2006
23
Isolated liver transplantation in pediatric short bowel syndrome: is there a role? (16677892)
2006
24
Enteric microbial flora, bacterial overgrowth, and short-bowel syndrome. (16431299)
2006
25
Criteria for the use of recombinant human growth hormone in short bowel syndrome. (16207690)
2005
26
Fasting breath hydrogen concentration in short bowel syndrome patients with colon incontinuity before and after antibiotic therapy. (14962684)
2004
27
Gastrocolocutaneous fistula in a child with congenital short bowel syndrome: a rare complication of percutaneous endoscopic gastrostomy. (15175828)
2004
28
Results of growth trophic therapy in children with short bowel syndrome. (15017548)
2004
29
A new neovalve type in short bowel syndrome surgery. (15255020)
2004
30
The use of oral tacrolimus in a case of short bowel syndrome. (12955349)
2004
31
Glucagon-like peptide-2 induces intestinal adaptation in parenterally fed rats with short bowel syndrome. (14962847)
2004
32
New and emerging therapies for short bowel syndrome in children. (12895135)
2003
33
Low-fat diet impairs postresection intestinal adaptation in a rat model of short bowel syndrome. (12891489)
2003
34
Peptide growth factors and intestinal adaptation in short bowel syndrome. (12725139)
2003
35
Endotoxemia inhibits intestinal adaptation in a rat model of short bowel syndrome. (12558147)
2003
36
A case of hypokalemia and rhabdomyolysis in a patient with short bowel syndrome. (12903898)
2003
37
Low-dose growth hormone in adult home parenteral nutrition-dependent short bowel syndrome patients: a positive study. (12557135)
2003
38
Effect of transforming growth factor-alpha on intestinal adaptation in a rat model of short bowel syndrome. (12505047)
2002
39
The management of patients with the short bowel syndrome. (11833063)
2002
40
Nutritional management of short bowel syndrome in adults. (11873098)
2002
41
Nutritional management of short bowel syndrome. (12230319)
2002
42
Short bowel syndrome. (12216714)
2002
43
Effect of bowel resection and high-fat diet on heart CD36/fatty-acid translocase expression in a rat model of short-bowel syndrome. (12471478)
2002
44
Enhancing bowel adaptation in short bowel syndrome. (12149180)
2002
45
Acute renal failure and metabolic disturbances in the short bowel syndrome. (11834771)
2002
46
Enteral nutrition in short bowel syndrome. (11329607)
2001
47
Intestinal transplantation for children with short bowel syndrome. (11329611)
2001
48
Effect of administration of Lactobacillus casei shirota on sodium balance in an infant with short bowel syndrome. (11396828)
2001
49
Epidermal growth factor and the short bowel syndrome. (10483910)
1999
50
Human gut hormone profiles in patients with short bowel syndrome. (1563315)
1992

Genetic Variations for Short Bowel Syndrome

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Expression for genes affiliated with Short Bowel Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Short Bowel Syndrome

Search GEO for disease gene expression data for Short Bowel Syndrome.

Pathways for genes affiliated with Short Bowel Syndrome

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53Reactome, 29KEGG, 51QIAGEN, 49PharmGKB
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Pathways related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2GCG, DPP4
210.1SLC9A2, SLC9A3
310.1DPP4, SLC9A3, SLC15A1
4
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10.0SLC15A1, SLC9A2, SLC9A3
5
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10.0FGF7, GH1, EGF, HGF
6
Hide members
9.8EGF, FGF7, SLC9A3, SLC9A2
7
Hide members
9.8FGF7, GH1, EGF, HGF, GCG
8
Hide members
9.7ABCB7, SLC9A3, SLC9A2, SLC15A1, SLC5A2
9
Hide members
9.6HGF, EGF, GH1, FGF7, SLC9A3, SLC9A2
10
Hide members
9.5PTH, GCG, PYY, CCK, GH1, NTS
11
Hide members
9.2GCG, PYY, CCK, EGF, GH1, NTS

Compounds for genes affiliated with Short Bowel Syndrome

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.7ABCB7
2pge24410.7SST
3hydrocortisone44 2 59 1113.6SLC9A3, GH1
4norepinephrine44 11 2412.5CCK, NTS, PYY
5enterogastrone4410.5CCK, PYY, GCG
6pramlintide44 1111.4PYY, CCK, DPP4, GCG
7incretin4410.4PYY, DPP4, CCK, GCG
8intralipid4410.4PYY, SST, GH1, CCK
9pirenzepine44 28 1112.4CCK, GH1, GCG, SST
10dtpa4410.3NTS, GCG, CCK, SST
11oxyntomodulin44 5911.3CCK, NTS, PYY, GCG, SST
12loxiglumide4410.3SST, NTS, CCK
13alpha-aminobutyric acid44 1111.3EGF, DPP4, GCG
14forskolin44 49 1112.3PTH, CCK, GCG, FGF7
15clonidine44 28 1112.3NTS, SLC15A1, SST, GH1, PYY
16amphetamine44 1111.3GCG, PYY, CCK, SST, NTS
17gnrh4410.3GH1, GCG, PYY, NTS
18dopamine44 28 11 2413.3GCG, CCK, NTS, PYY
19bicarbonate4410.2SLC9A2, SLC9A3, CCK, NTS
20atropine44 28 1112.2CCK, GH1, NTS, SST, PYY, GCG
21cycloheximide4410.2SLC9A3, PTH, HGF, FGF7, DPP4
22c-peptide4410.1GCG, PYY, GH1, DPP4, CCK, NTS
23ibmx44 28 5912.1SST, PTH, GH1, EGF, CCK, GCG
24octreotide44 59 28 1113.1SST, EGF, NTS, GH1, GCG, PYY
25dexamethasone44 49 28 1113.1SLC9A3, HGF, CCK, GH1, NTS, PTH
26isoproterenol44 1111.1PTH, NTS, GH1, PYY, GCG, SST
27ursodeoxycholic acid44 11 2412.1HGF, CCK, DPP4, ABCB7
28histamine44 28 2412.0GCG, HGF, PYY, CCK, NTS, SST
295fluorouracil4410.0FGF7, HGF, EGF, SST, SLC15A1, CCK
30acetylcholine44 49 28 11 2414.0FGF7, GCG, CCK, PYY, GH1, NTS
31streptozotocin4410.0SST, DPP4, HGF, GCG
32naloxone44 49 28 1112.9NTS, SST, GH1, CCK
335-hydroxytryptamine449.9SST, NTS, CCK, PYY, GCG
34carbachol44 28 1111.9EGF, SST, NTS, SLC9A3, CCK, PYY
35glucose449.9SLC5A2, SLC9A3, NTS, CCK, PYY, GCG
36heparin44 28 11 2412.8GH1, NTS, FGF7, EGF, HGF, GCG
37genistein44 28 59 2 11 2414.8SLC9A3, FGF7, SST, GH1, GCG, EGF
38thymidine44 2410.8HGF, PTH, EGF, FGF7, GH1, PYY
39lactate449.8GH1, GCG, HGF, SST, ABCB7, SLC9A3
40glutamine449.8CCK, HGF, EGF, SLC9A3, FGF7, GCG
41arginine449.8GH1, HGF, CCK, PTH, SLC5A2, SST
42alanine449.8ABCB7, HGF, GH1, SLC9A3, NTS, GLP2R
43testosterone44 59 11 2412.8ABCB7, FGF7, SST, NTS, GH1, EGF
44creatinine449.7DPP4, PTH, GCG, HGF, GH1, SLC9A3
45sodium44 2410.6FGF7, DPP4, ABCB7, SLC9A3, SLC9A2, SLC15A1
46glutamate449.6CCK, SLC15A1, HGF, NTS, DPP4, ABCB7
47thyroxine44 2410.6SST, GH1, NTS, PTH, ABCB7
48adenylate449.5HGF, FGF7, SLC9A3, DPP4, SST, PTH
49tyrosine449.4PYY, DPP4, CCK, GH1, HGF, FGF7
50serine449.3NTS, HGF, GCG, PYY, EGF, GH1

GO Terms for genes affiliated with Short Bowel Syndrome

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16Gene Ontology
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Cellular components related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.5HGF, PYY, CCK, EGF, GH1, SST
2extracellular regionGO:0055768.9PTH, GCG, HGF, PYY, CCK, EGF

Biological processes related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:00862810.4PTH, SST
2regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.3HGF, FGF7
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.1FGF7, GH1, CCK, HGF
4digestionGO:00758610.1PYY, SST, SLC15A1
5G-protein coupled receptor signaling pathwayGO:00718610.0PTH, SST, PYY, GCG
6positive regulation of peptidyl-threonine phosphorylationGO:0108009.9GCG, EGF
7positive regulation of cell proliferationGO:0082849.9FGF7, GLP2R, DPP4, EGF, CCK
8transmembrane transportGO:0550859.6SLC5A2, SLC15A1, SLC9A2, SLC9A3, ABCB7

Molecular functions related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.2PYY, CCK, NTS
2growth factor activityGO:0080839.9FGF7, GH1, EGF, HGF
3sodium:hydrogen antiporter activityGO:0153859.8SLC9A3, SLC9A2
4hormone activityGO:0051799.8PTH, SST, GH1, CCK, PYY, GCG
5protein bindingGO:0055158.9HGF, PYY, CCK, TNNC1, EGF, GH1

Products for genes affiliated with Short Bowel Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Short Bowel Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet