MCID: SHR001
MIFTS: 55

Short Bowel Syndrome malady

Gastrointestinal diseases category

Summaries for Short Bowel Syndrome

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. the main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. examples of treatment include diet and nutritional support, and in some cases intestinal transplantation. last updated: 4/29/2011

MalaCards: Short Bowel Syndrome, also known as acquired short bowel syndrome, is related to diarrhea and cholestasis. An important gene associated with Short Bowel Syndrome is PYY (peptide YY), and among its related pathways are Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) and Sodium/Proton exchangers. The compounds estradiol and pge2 have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Wikipedia:63 Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder... more...

Aliases & Classifications for Short Bowel Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

short bowel syndrome 8 42 10 44 60
acquired short bowel syndrome 8
short gut syndrome 8


External Ids:

Disease Ontology8 DOID:10605
MeSH34 D012778

Related Diseases for Short Bowel Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Short Bowel Syndrome:



Diseases related to short bowel syndrome

Clinical Features for Short Bowel Syndrome

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Drugs & Therapeutics for Short Bowel Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Short Bowel Syndrome

Drug clinical trials:

Search ClinicalTrials for Short Bowel Syndrome

Search NIH Clinical Center for Short Bowel Syndrome

Search CenterWatch for Short Bowel Syndrome

Genetic Tests for Short Bowel Syndrome

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Anatomical Context for Short Bowel Syndrome

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32MalaCards
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MalaCards organs/tissues related to Short Bowel Syndrome:

32
Small intestine, Liver, Colon, Bone, Skin, Kidney, Heart, Pancreas, Thyroid, Breast, Testes

Animal Models for Short Bowel Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Short Bowel Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.0SLC5A2, GLP2R, NTS, CCK
2MP:00053819.6EGF, GLP2R, SLC9A3, SLC9A2, SLC15A1
3MP:00053759.6PYY, GH1, NTS, GLP2R, SLC5A2
4MP:00053799.2GCG, CCK, EGF, GH1, DPP4, GLP2R
5MP:00053788.8GH1, EGF, PYY, HGF, GCG, NTS
6MP:00053768.6SLC5A2, GCG, PYY, CCK, GH1, NTS

Publications for Short Bowel Syndrome

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50PubMed
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Articles related to Short Bowel Syndrome:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Clinical, Social, and Economic Impacts of Home Parenteral Nutrition Dependence in Short Bowel Syndrome. (24418898)
2014
2
Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL) scale. (23274148)
2013
3
Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide--analyses from a randomised, placebo-controlled study. (23587733)
2013
4
Nutritional support process for a patient with short bowel syndrome in conjunction with panperitonitis: a case report. (23908982)
2013
5
Teduglutide enhances structural adaptation of the small intestinal mucosa in patients with short bowel syndrome. (23426461)
2013
6
Delayed primary serial transverse enteroplasty as a novel management strategy for infants with congenital ultra-short bowel syndrome. (23701772)
2013
7
Chronic calcium pyrophosphate crystal inflammatory arthritis induced by extreme hypomagnesemia in short bowel syndrome. (22998213)
2012
8
Multiple intestinal anastomoses to avoid short bowel syndrome and stimulate bowel maturity in type IV multiple intestinal atresia and necrotizing enterocolitis. (22424368)
2012
9
A comparison of a short nurse-based and a long multidisciplinary version of structured patient education in irritable bowel syndrome. (22617366)
2012
10
Intestinal rehabilitation and bowel reconstructive surgery: improved outcomes in children with short bowel syndrome. (21832945)
2012
11
Long-term impact of infantile short bowel syndrome on nutritional status and growth. (21917192)
2012
12
Macronutrient absorption characteristics in humans with short bowel syndrome and jejunocolonic anastomosis: starch is the most important carbohydrate substrate, although pectin supplementation may modestly enhance short chain fatty acid production and fluid absorption. (21378253)
2011
13
Serum vitamins in adult patients with short bowel syndrome receiving intermittent parenteral nutrition. (21628608)
2011
14
Ursodeoxycholic acid promotes intestinal adaptation in a cat model of short bowel syndrome. (21210842)
2011
15
Short bowel syndrome: a review of management options. (21727727)
2011
16
Effects of probiotics on experimental short-bowel syndrome. (21722874)
2011
17
The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. (20171649)
2010
18
Ureteroiliac artery fistula in a young woman with short bowel syndrome for radiation enteritis. (20300556)
2010
19
Shoshin beriberi mimicking central line sepsis in a child with short bowel syndrome. (20127217)
2010
20
Elimination of soybean lipid emulsion in parenteral nutrition and supplementation with enteral fish oil improve cholestasis in infants with short bowel syndrome. (20413701)
2010
21
Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome. (19095767)
2009
22
Vestibular evaluation using videonystagmography of chronic zinc deficient patients due to short bowel syndrome. (19575118)
2009
23
Novel intravenous (13)C-methionine breath test as a measure of liver function in children with short bowel syndrome. (19159749)
2009
24
Intestinal lengthening for short bowel syndrome. (18953809)
2008
25
Improved survival in a multidisciplinary short bowel syndrome program. (18206449)
2008
26
Autologous gastrointestinal reconstruction for short bowel syndrome. (17260708)
2007
27
Changes in urinary level and configuration ratio of D-lactic acid in patients with short bowel syndrome. (17403621)
2007
28
Neonatal short bowel syndrome outcomes after the establishment of the first Canadian multidisciplinary intestinal rehabilitation program: preliminary experience. (17502188)
2007
29
Two-hit rat model of short bowel syndrome and sepsis: independent of total parenteral nutrition, short bowel syndrome is proinflammatory and injurious to the liver. (17560208)
2007
30
Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome. (16710856)
2006
31
Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome. (16923138)
2006
32
Cryptosporidium parvum diarrhea in an infant with short bowel syndrome. (16481235)
2006
33
New growth factor therapies aimed at improving intestinal adaptation in short bowel syndrome. (16724975)
2006
34
Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. (16244538)
2005
35
Dipeptidyl-peptidase IV in patients with short bowel syndrome. (16169633)
2005
36
Pediatric short bowel syndrome: redefining predictors of success. (16135926)
2005
37
Advances in the management of short bowel syndrome. (16168235)
2005
38
Neonatal short bowel syndrome: a cohort study. (15937809)
2005
39
The effect of growth hormone supplementation on late nutritional independence in pediatric patients with short bowel syndrome. (15750945)
2005
40
The effects of long-term total parenteral nutrition on gut mucosal immunity in children with short bowel syndrome: a systematic review. (15686591)
2005
41
A prospective within-patient comparison clinical trial on the effect of parenteral cimetidine for improvement of fluid secretion and electrolyte balance in patients with short bowel syndrome. (15532817)
2004
42
Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: a 25-year experience. (15289760)
2004
43
Management of the short bowel syndrome after extensive small bowel resection. (15494290)
2004
44
Short bowel syndrome after trauma. (15619501)
2004
45
Surgical therapy for short bowel syndrome. (15449081)
2004
46
3-0 methylglucose absorption in vivo correlates with nutrient absorption and intestinal surface area in experimental short bowel syndrome. (12549601)
2003
47
Distribution of the H+/peptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. (11976168)
2002
48
Nutritional effects of surgical and medical treatment for short bowel syndrome. (11688938)
2001
49
Effect of glutamine in short-bowel syndrome. (11478829)
2001
50
Enteral glutamine does not enhance the effects of hepatocyte growth factor in short bowel syndrome. (9856891)
1998

Genetic Variations for Short Bowel Syndrome

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Expression for genes affiliated with Short Bowel Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Short Bowel Syndrome

Search GEO for disease gene expression data for Short Bowel Syndrome.

Pathways for genes affiliated with Short Bowel Syndrome

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53Reactome, 29KEGG, 51QIAGEN, 49PharmGKB
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Pathways related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2GCG, DPP4
210.1SLC9A2, SLC9A3
310.1DPP4, SLC9A3, SLC15A1
4
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10.0SLC15A1, SLC9A2, SLC9A3
5
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10.0FGF7, GH1, EGF, HGF
6
Hide members
9.8EGF, FGF7, SLC9A3, SLC9A2
7
Hide members
9.8FGF7, GH1, EGF, HGF, GCG
8
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9.7ABCB7, SLC9A3, SLC9A2, SLC15A1, SLC5A2
9
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9.6HGF, EGF, GH1, FGF7, SLC9A3, SLC9A2
10
Hide members
9.5PTH, GCG, PYY, CCK, GH1, NTS
11
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9.2GCG, PYY, CCK, EGF, GH1, NTS

Compounds for genes affiliated with Short Bowel Syndrome

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1estradiol44 11 2412.7ABCB7
2pge24410.7SST
3hydrocortisone44 2 59 1113.6SLC9A3, GH1
4norepinephrine44 11 2412.5CCK, NTS, PYY
5enterogastrone4410.5CCK, PYY, GCG
6pramlintide44 1111.4PYY, CCK, DPP4, GCG
7incretin4410.4PYY, DPP4, CCK, GCG
8intralipid4410.4PYY, SST, GH1, CCK
9pirenzepine44 28 1112.4CCK, GH1, GCG, SST
10dtpa4410.3NTS, GCG, CCK, SST
11oxyntomodulin44 5911.3CCK, NTS, PYY, GCG, SST
12loxiglumide4410.3SST, NTS, CCK
13alpha-aminobutyric acid44 1111.3EGF, DPP4, GCG
14forskolin44 49 1112.3PTH, CCK, GCG, FGF7
15clonidine44 28 1112.3NTS, SLC15A1, SST, GH1, PYY
16amphetamine44 1111.3GCG, PYY, CCK, SST, NTS
17gnrh4410.3GH1, GCG, PYY, NTS
18dopamine44 28 11 2413.3GCG, CCK, NTS, PYY
19bicarbonate4410.2SLC9A2, SLC9A3, CCK, NTS
20atropine44 28 1112.2CCK, GH1, NTS, SST, PYY, GCG
21cycloheximide4410.2SLC9A3, PTH, HGF, FGF7, DPP4
22c-peptide4410.1GCG, PYY, GH1, DPP4, CCK, NTS
23ibmx44 28 5912.1SST, PTH, GH1, EGF, CCK, GCG
24octreotide44 59 28 1113.1SST, EGF, NTS, GH1, GCG, PYY
25dexamethasone44 49 28 1113.1SLC9A3, HGF, CCK, GH1, NTS, PTH
26isoproterenol44 1111.1PTH, NTS, GH1, PYY, GCG, SST
27ursodeoxycholic acid44 11 2412.1HGF, CCK, DPP4, ABCB7
28histamine44 28 2412.0GCG, HGF, PYY, CCK, NTS, SST
295fluorouracil4410.0FGF7, HGF, EGF, SST, SLC15A1, CCK
30acetylcholine44 49 28 11 2414.0FGF7, GCG, CCK, PYY, GH1, NTS
31streptozotocin4410.0SST, DPP4, HGF, GCG
32naloxone44 49 28 1112.9NTS, SST, GH1, CCK
335-hydroxytryptamine449.9SST, NTS, CCK, PYY, GCG
34carbachol44 28 1111.9EGF, SST, NTS, SLC9A3, CCK, PYY
35glucose449.9SLC5A2, SLC9A3, NTS, CCK, PYY, GCG
36heparin44 28 11 2412.8GH1, NTS, FGF7, EGF, HGF, GCG
37genistein44 28 59 2 11 2414.8SLC9A3, FGF7, SST, GH1, GCG, EGF
38thymidine44 2410.8HGF, PTH, EGF, FGF7, GH1, PYY
39lactate449.8GH1, GCG, HGF, SST, ABCB7, SLC9A3
40glutamine449.8CCK, HGF, EGF, SLC9A3, FGF7, GCG
41arginine449.8GH1, HGF, CCK, PTH, SLC5A2, SST
42alanine449.8ABCB7, HGF, GH1, SLC9A3, NTS, GLP2R
43testosterone44 59 11 2412.8ABCB7, FGF7, SST, NTS, GH1, EGF
44creatinine449.7DPP4, PTH, GCG, HGF, GH1, SLC9A3
45sodium44 2410.6FGF7, DPP4, ABCB7, SLC9A3, SLC9A2, SLC15A1
46glutamate449.6CCK, SLC15A1, HGF, NTS, DPP4, ABCB7
47thyroxine44 2410.6SST, GH1, NTS, PTH, ABCB7
48adenylate449.5HGF, FGF7, SLC9A3, DPP4, SST, PTH
49tyrosine449.4PYY, DPP4, CCK, GH1, HGF, FGF7
50serine449.3NTS, HGF, GCG, PYY, EGF, GH1

GO Terms for genes affiliated with Short Bowel Syndrome

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16Gene Ontology
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Cellular components related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.5HGF, PYY, CCK, EGF, GH1, SST
2extracellular regionGO:0055768.9PTH, GCG, HGF, PYY, CCK, EGF

Biological processes related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:00862810.4PTH, SST
2regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.3HGF, FGF7
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.1FGF7, GH1, CCK, HGF
4digestionGO:00758610.1PYY, SST, SLC15A1
5G-protein coupled receptor signaling pathwayGO:00718610.0PTH, SST, PYY, GCG
6positive regulation of peptidyl-threonine phosphorylationGO:0108009.9GCG, EGF
7positive regulation of cell proliferationGO:0082849.9FGF7, GLP2R, DPP4, EGF, CCK
8transmembrane transportGO:0550859.6SLC5A2, SLC15A1, SLC9A2, SLC9A3, ABCB7

Molecular functions related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.2PYY, CCK, NTS
2growth factor activityGO:0080839.9FGF7, GH1, EGF, HGF
3sodium:hydrogen antiporter activityGO:0153859.8SLC9A3, SLC9A2
4hormone activityGO:0051799.8PTH, SST, GH1, CCK, PYY, GCG
5protein bindingGO:0055158.9HGF, PYY, CCK, TNNC1, EGF, GH1

Products for genes affiliated with Short Bowel Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Short Bowel Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet