MCID: SHR001
MIFTS: 53

Short Bowel Syndrome malady

Gastrointestinal category

Summaries for Short Bowel Syndrome

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. the main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. examples of treatment include diet and nutritional support, and in some cases intestinal transplantation. last updated: 4/29/2011

MalaCards: Short Bowel Syndrome, also known as acquired short bowel syndrome, is related to glucagonoma and glucose intolerance. An important gene associated with Short Bowel Syndrome is PYY (peptide YY), and among its related pathways are Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) and Sodium/Proton exchangers. The compounds estradiol and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and kidney, and related mouse phenotypes are no phenotypic analysis and digestive/alimentary.

Wikipedia:64 Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder... more...

Aliases & Classifications for Short Bowel Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

short bowel syndrome 8 43 10 45 61
acquired short bowel syndrome 8
short gut syndrome 8


External Ids:

Disease Ontology8 DOID:10605
MeSH35 D012778

Related Diseases for Short Bowel Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Short Bowel Syndrome:



Diseases related to short bowel syndrome

Clinical Features for Short Bowel Syndrome

Drugs & Therapeutics for Short Bowel Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Short Bowel Syndrome

Drug clinical trials:

Search ClinicalTrials for Short Bowel Syndrome

Search NIH Clinical Center for Short Bowel Syndrome

Search CenterWatch for Short Bowel Syndrome

Genetic Tests for Short Bowel Syndrome

Anatomical Context for Short Bowel Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Short Bowel Syndrome:

33
Skin, Liver, Kidney, Heart, Small intestine, Colon, Pancreas, Thyroid, Breast, B cells

Animal Models for Short Bowel Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Short Bowel Syndrome

Sources:
51PubMed
See all sources

Articles related to Short Bowel Syndrome:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations. (23037936)
2013
2
Teduglutide: a review of its use in the treatment of patients with short bowel syndrome. (23729002)
2013
3
Management of short bowel syndrome in infancy. (24125822)
2013
4
D-lactic acidosis: an unusual cause of encephalopathy in a patient with short bowel syndrome. (24156228)
2013
5
Intestinal rehabilitation and bowel reconstructive surgery: improved outcomes in children with short bowel syndrome? (22197947)
2012
6
Role of growth hormone, glutamine and enteral nutrition in pediatric short bowel syndrome: a pilot follow-up study. (22161076)
2012
7
Second serial transverse enteroplasty procedure in an infant with extreme short bowel syndrome. (22690105)
2012
8
Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome. (22570676)
2012
9
Serial transverse enteroplasty (STEP): intermediate outcomes in children with short bowel syndrome. (22476506)
2012
10
Impact of infantile short bowel syndrome on long-term health-related quality of life: a cross-sectional study. (22813789)
2012
11
Radiation therapy increases the risk of hepatobiliary complications in short bowel syndrome. (21775643)
2011
12
Enteral fish oil for treatment of parenteral nutrition-associated liver disease in six infants with short-bowel syndrome. (21923431)
2011
13
Colonic GLP-2 is not sufficient to promote jejunal adaptation in a PN-dependent rat model of human short bowel syndrome. (19644131)
2009
14
Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome. (19389806)
2009
15
Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome. (19433172)
2009
16
What is the current role for parenteral lipid emulsions containing omega-3 fatty acids in infants with short bowel syndrome? (19461570)
2009
17
Palliative Percutaneous Jejunal Stent for Patients with Short Bowel Syndrome. (20651969)
2009
18
Pediatric short-bowel syndrome: the cost of comprehensive care. (19064515)
2008
19
Muscle mass gain observed in patients with short bowel syndrome subjected to resistance training. (19083392)
2008
20
Short bowel syndrome in the research setting: 15 years' experience]. (18624270)
2008
21
Nutrient intake from habitual oral diet in patients with severe short bowel syndrome living in the southeastern United States. (18328409)
2008
22
Acrodermatitis enteropathica-like skin eruption in a case of short bowel syndrome following jejuno-transverse colon anastomosis. (18328214)
2007
23
Are plasma citrulline and glutamine biomarkers of intestinal absorptive function in patients with short bowel syndrome? (17202433)
2007
24
Living long with short bowel syndrome: a historical case of twenty-nine years of living with home parenteral nutrition. (17308253)
2007
25
Effects of continuous enteral L-arginine in a rat model of the short bowel syndrome. (17704037)
2007
26
Short bowel syndrome. (17298760)
2007
27
Economic implications of growth hormone use in patients with short bowel syndrome. (17022865)
2006
28
Short bowel syndrome following bariatric surgical procedures. (17161102)
2006
29
Guidelines for pharmacotherapy, nutritional management, and weaning parenteral nutrition in adult patients with short bowel syndrome: introduction. (16770165)
2006
30
Small bowel volvulus leading to gangrene and short bowel syndrome. (15670531)
2005
31
Clinical evidence of growth hormone, glutamine and a modified diet for short bowel syndrome: meta-analysis of clinical trials. (15734715)
2005
32
Operative strategies for necrotizing enterocolitis: The prevention and treatment of short-bowel syndrome. (16084407)
2005
33
Managing short bowel syndrome: making the most of what the patient still has. (16193832)
2005
34
Evaluation of intestinal absorption after longitudinal intestinal lengthening for short bowel syndrome. (16226989)
2005
35
Short bowel syndrome: clinical guidelines for nutrition management. (16207689)
2005
36
Hypomagnesemia and chondrocalcinosis in short bowel syndrome. (16331778)
2005
37
Total parenteral nutrition, intestinal adaptation, and short bowel syndrome. (14990282)
2004
38
Delayed onset of ataxia in a patient with short bowel syndrome: a case of vitamin E deficiency. (15526994)
2004
39
The medical and surgical management of short bowel syndrome. (15266238)
2004
40
The nutritional management of short bowel syndrome. (15624543)
2004
41
Quality of life and concerns in patients with short bowel syndrome. (14512031)
2003
42
Factors affecting prognosis in patients with short bowel syndrome. (14664187)
2003
43
A case study utilizing an enteral refeeding technique in a premature infant with short bowel syndrome. (14695498)
2003
44
Morbidity and mortality of short-bowel syndrome in infants with abdominal wall defects. (12467323)
2002
45
Short bowel syndrome: a nutritional and medical approach. (12041848)
2002
46
Short bowel syndrome in the elderly. (16214972)
2002
47
Synovial lipomatosis (lipoma arborescens) affecting multiple joints in a patient with congenital short bowel syndrome. (12022328)
2002
48
Pharmacotherapy and growth factors in the treatment of short bowel syndrome. (11329609)
2001
49
Measurement of total body water in patients with short-bowel syndrome. (11377142)
2001
50
Warfarin resistance in a patient with short bowel syndrome. (9620117)
1998

Genetic Variations for Short Bowel Syndrome

Expression for genes affiliated with Short Bowel Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Short Bowel Syndrome

Search GEO for disease gene expression data for Short Bowel Syndrome.

Pathways for genes affiliated with Short Bowel Syndrome

Sources:
54Reactome, 30KEGG, 52QIAGEN, 50PharmGKB
See all sources

Pathways related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2GCG, DPP4
210.1SLC9A2, SLC9A3
310.1DPP4, SLC9A3, SLC15A1
4
Hide members
10.0SLC15A1, SLC9A2, SLC9A3
5
Hide members
10.0FGF7, GH1, EGF, HGF
6
Hide members
9.8EGF, FGF7, SLC9A3, SLC9A2
7
Hide members
9.8FGF7, GH1, EGF, HGF, GCG
8
Hide members
9.7ABCB7, SLC9A3, SLC9A2, SLC15A1, SLC5A2
9
Hide members
9.6HGF, EGF, GH1, FGF7, SLC9A3, SLC9A2
10
Hide members
9.5PTH, GCG, PYY, CCK, GH1, NTS
11
Hide members
9.2GCG, PYY, CCK, EGF, GH1, NTS

Compounds for genes affiliated with Short Bowel Syndrome

Sources:
45Novoseek, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1estradiol45 11 2412.7ABCB7
2pge24510.7SST
3hydrocortisone45 2 60 1113.6SLC9A3, GH1
4norepinephrine45 11 2412.5CCK, NTS, PYY
5enterogastrone4510.5CCK, PYY, GCG
6pramlintide45 1111.4PYY, CCK, DPP4, GCG
7incretin4510.4PYY, DPP4, CCK, GCG
8intralipid4510.4PYY, SST, GH1, CCK
9pirenzepine45 29 1112.4CCK, GH1, GCG, SST
10dtpa4510.3NTS, GCG, CCK, SST
11oxyntomodulin45 6011.3CCK, NTS, PYY, GCG, SST
12loxiglumide4510.3SST, NTS, CCK
13alpha-aminobutyric acid45 1111.3EGF, DPP4, GCG
14forskolin45 50 1112.3PTH, CCK, GCG, FGF7
15clonidine45 29 1112.3NTS, SLC15A1, SST, GH1, PYY
16amphetamine45 1111.3GCG, PYY, CCK, SST, NTS
17gnrh4510.3GH1, GCG, PYY, NTS
18dopamine45 29 11 2413.3GCG, CCK, NTS, PYY
19bicarbonate4510.2SLC9A2, SLC9A3, CCK, NTS
20atropine45 29 1112.2CCK, GH1, NTS, SST, PYY, GCG
21cycloheximide4510.2SLC9A3, PTH, HGF, FGF7, DPP4
22c-peptide4510.1GCG, PYY, GH1, DPP4, CCK, NTS
23ibmx45 29 6012.1SST, PTH, GH1, EGF, CCK, GCG
24octreotide45 60 29 1113.1SST, EGF, NTS, GH1, GCG, PYY
25dexamethasone45 50 29 1113.1SLC9A3, HGF, CCK, GH1, NTS, PTH
26isoproterenol45 1111.1PTH, NTS, GH1, PYY, GCG, SST
27ursodeoxycholic acid45 11 2412.1HGF, CCK, DPP4, ABCB7
28histamine45 29 2412.0GCG, HGF, PYY, CCK, NTS, SST
295fluorouracil4510.0FGF7, HGF, EGF, SST, SLC15A1, CCK
30acetylcholine45 50 29 11 2414.0FGF7, GCG, CCK, PYY, GH1, NTS
31streptozotocin4510.0SST, DPP4, HGF, GCG
32naloxone45 50 29 1112.9NTS, SST, GH1, CCK
335-hydroxytryptamine459.9SST, NTS, CCK, PYY, GCG
34carbachol45 29 1111.9EGF, SST, NTS, SLC9A3, CCK, PYY
35glucose459.9SLC5A2, SLC9A3, NTS, CCK, PYY, GCG
36heparin45 29 11 2412.8GH1, NTS, FGF7, EGF, HGF, GCG
37genistein45 29 60 2 11 2414.8SLC9A3, FGF7, SST, GH1, GCG, EGF
38thymidine45 2410.8HGF, PTH, EGF, FGF7, GH1, PYY
39lactate459.8GH1, GCG, HGF, SST, ABCB7, SLC9A3
40glutamine459.8CCK, HGF, EGF, SLC9A3, FGF7, GCG
41arginine459.8GH1, HGF, CCK, PTH, SLC5A2, SST
42alanine459.8ABCB7, HGF, GH1, SLC9A3, NTS, GLP2R
43testosterone45 60 11 2412.8ABCB7, FGF7, SST, NTS, GH1, EGF
44creatinine459.7DPP4, PTH, GCG, HGF, GH1, SLC9A3
45sodium45 2410.6FGF7, DPP4, ABCB7, SLC9A3, SLC9A2, SLC15A1
46glutamate459.6CCK, SLC15A1, HGF, NTS, DPP4, ABCB7
47thyroxine45 2410.6SST, GH1, NTS, PTH, ABCB7
48adenylate459.5HGF, FGF7, SLC9A3, DPP4, SST, PTH
49tyrosine459.4PYY, DPP4, CCK, GH1, HGF, FGF7
50serine459.3NTS, HGF, GCG, PYY, EGF, GH1

GO Terms for genes affiliated with Short Bowel Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.5HGF, PYY, CCK, EGF, GH1, SST
2extracellular regionGO:0055768.9PTH, GCG, HGF, PYY, CCK, EGF

Biological processes related to Short Bowel Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:00862810.4PTH, SST
2regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:06066510.3HGF, FGF7
3positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.1FGF7, GH1, CCK, HGF
4digestionGO:00758610.1PYY, SST, SLC15A1
5G-protein coupled receptor signaling pathwayGO:00718610.0PTH, SST, PYY, GCG
6positive regulation of peptidyl-threonine phosphorylationGO:0108009.9GCG, EGF
7positive regulation of cell proliferationGO:0082849.9FGF7, GLP2R, DPP4, EGF, CCK
8transmembrane transportGO:0550859.6SLC5A2, SLC15A1, SLC9A2, SLC9A3, ABCB7

Molecular functions related to Short Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00518410.2PYY, CCK, NTS
2growth factor activityGO:0080839.9FGF7, GH1, EGF, HGF
3sodium:hydrogen antiporter activityGO:0153859.8SLC9A3, SLC9A2
4hormone activityGO:0051799.8PTH, SST, GH1, CCK, PYY, GCG
5protein bindingGO:0055158.9HGF, PYY, CCK, TNNC1, EGF, GH1

Products for genes affiliated with Short Bowel Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Short Bowel Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet