MCID: SHR001
MIFTS: 45

Short Bowel Syndrome malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Fetal diseases categories

Summaries for Short Bowel Syndrome

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NIH Rare Diseases:41 Short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. the main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. examples of treatment include diet and nutritional support, and in some cases intestinal transplantation. last updated: 4/29/2011

MalaCards based summary: Short Bowel Syndrome, also known as acquired short bowel syndrome, is related to congenital short bowel syndrome and intestinal pseudo-obstruction. An important gene associated with Short Bowel Syndrome is CLMP (CXADR-like membrane protein), and among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. The compounds enterogastrone and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are growth/size/body and nervous system.

Wikipedia:63 Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder... more...

Aliases & Classifications for Short Bowel Syndrome

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Short Bowel Syndrome, Aliases & Descriptions:

Name: Short Bowel Syndrome 9 41 11 43 60
Acquired Short Bowel Syndrome 9
 
Short Gut Syndrome 9


Classifications:



External Ids:

Disease Ontology9 DOID:10605
MeSH33 D012778

Related Diseases for Short Bowel Syndrome

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Diseases in the Short Bowel Syndrome family:

Congenital Short Bowel Syndrome Secondary Short Bowel Syndrome

Diseases related to Short Bowel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1congenital short bowel syndrome31.3CLMP, FLNA
2intestinal pseudo-obstruction30.8SST
3diarrhea30.7SST, PYY
4glucose intolerance30.4PYY, CCK
5glucagonoma30.4SST, CCK
6pancreatitis30.2CCK, SST
7celiac disease30.1DPP4, CCK, PYY
8obesity29.6NTS, DPP4, CCK, PYY
9liver disease10.6
10eating disorder10.5PYY
11zollinger-ellison syndrome10.4SST
12lactic acidosis10.4
13crohn's disease10.3
14gastroschisis10.3
15blindness10.3
16secondary short bowel syndrome10.3
17serotonin syndrome10.2PYY, SST
18gallbladder disease10.2PYY, CCK
19bulimia nervosa10.2CCK, PYY
20morbid obesity10.2CCK, PYY
21constipation10.2PYY, CCK
22steatorrhea10.2SST, CCK
23gastrointestinal system disease10.2PYY, CCK
24cholelithiasis10.2SST, CCK
25arthritis10.2
26intestinal atresia10.2
27hypokalemia10.2
28xerophthalmia10.2
29cholestasis10.2
30prader-willi syndrome10.2CCK, PYY
31duodenal ulcer10.2CCK, SST
32peptic ulcer disease10.2CCK, SST
33nutritional deficiency disease10.2CCK, PYY
34acromegaly10.2CCK, SST
35acute pancreatitis10.1CCK, SST
36vipoma10.1SST, NTS
37pancreatic cancer10.1CCK, SST
38duodenogastric reflux10.1NTS, CCK
39kawasaki disease10.0
40bacteremia10.0
41lipoma10.0
42acrodermatitis enteropathica10.0
43intestinal pseudoobstruction, neuronal10.0
44hepatitis10.0
45leukemia10.0
46acrodermatitis10.0
47chondrocalcinosis10.0
48portal hypertension10.0
49osteomalacia10.0
50imperforate anus10.0

Graphical network of the top 20 diseases related to Short Bowel Syndrome:



Diseases related to short bowel syndrome

Symptoms for Short Bowel Syndrome

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Drugs & Therapeutics for Short Bowel Syndrome

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Drug clinical trials:

Search ClinicalTrials for Short Bowel Syndrome

Search NIH Clinical Center for Short Bowel Syndrome

Genetic Tests for Short Bowel Syndrome

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Anatomical Context for Short Bowel Syndrome

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MalaCards organs/tissues related to Short Bowel Syndrome:

31
Small intestine, Liver, Colon, Bone, Skin, Heart, Kidney, Pancreas, Thyroid, Breast, Testes

Animal Models for Short Bowel Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Short Bowel Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.6NTS, DPP4, SST, FLNA, PYY
2MP:00036317.3PYY, FLNA, SST, CCK, NTS
3MP:00053767.0NTS, DPP4, CCK, SST, FLNA, PYY

Publications for Short Bowel Syndrome

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Articles related to Short Bowel Syndrome:

(show top 50)    (show all 550)
idTitleAuthorsYear
1
Bowel-associated dermatosis-arthritis syndrome in an adolescent with short bowel syndrome. (25160016)
2014
2
Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease. (24999016)
2014
3
Short bowel syndrome and clopidogrel non-responsiveness: a new indication for platelet aggregometry? (25115778)
2014
4
Temporary Parenteral Tacrolimus Requirement due to Unexplained Low Through Levels in a Liver Transplant Patient with Short Bowel Syndrome. (25013677)
2014
5
Short bowel syndrome in children: surgical and medical perspectives. (25459014)
2014
6
Persistent metabolic acidosis in a hemodialyzed patient with short bowel syndrome. (23774551)
2013
7
Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations. (23037936)
2013
8
Key issues in addressing the clinical and humanistic burden of short bowel syndrome in the US. (23480444)
2013
9
Study of teduglutide effectiveness in parenteral nutrition-dependent short-bowel syndrome subjects. (24134154)
2013
10
Vitamin K status in patients with short bowel syndrome. (22633417)
2012
11
Short bowel syndrome in children: current and potential therapies. (22452596)
2012
12
Intestinal rehabilitation and bowel reconstructive surgery: improved outcomes in children with short bowel syndrome? (22197947)
2012
13
Long-term nutritional assessment of patients with severe short bowel syndrome managed with home enteral nutrition and oral intake. (22470032)
2011
14
Plasma citrulline as marker of bowel adaptation in children with short bowel syndrome. (21630079)
2011
15
Intestinal lengthening in adult patients with short bowel syndrome. (20734155)
2010
16
The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. (20171649)
2010
17
Enteral nutrition in children with short-bowel syndrome: current evidence and recommendations for the clinician. (20184992)
2010
18
Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. (19179884)
2009
19
Pediatric short-bowel syndrome: the cost of comprehensive care. (19064515)
2008
20
Growth and nutritional aspects of infantile short bowel syndrome for the past 2 decades. (18970941)
2008
21
Congenital short bowel syndrome: a case report and review of the literature. (18209785)
2008
22
Chronically administered retinoic acid has trophic effects in the rat small intestine and promotes adaptation in a resection model of short bowel syndrome. (17307727)
2007
23
Autologous gastrointestinal reconstruction for short bowel syndrome. (17260708)
2007
24
Intestinal transplantation for short bowel syndrome and gastrointestinal failure: current consensus, rewarding outcomes, and practical guidelines. (16473061)
2006
25
Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. (16244538)
2005
26
Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome. (15991189)
2005
27
Recurrent D-lactic acidosis in a child with short bowel syndrome. (15927940)
2005
28
Small bowel volvulus leading to gangrene and short bowel syndrome. (15670531)
2005
29
Treatment of restless legs syndrome with subcutaneous apomorphine in a patient with short bowel syndrome. (15726274)
2005
30
Dipeptidyl-peptidase IV in patients with short bowel syndrome. (16169633)
2005
31
Enteric-coated cholylsarcosine microgranules for the treatment of short bowel syndrome. (15638993)
2005
32
A useful experimental model of short bowel syndrome. (14761823)
2004
33
Surgical rehabilitation of intestine in short bowel syndrome. (15118580)
2004
34
A prospective within-patient comparison clinical trial on the effect of parenteral cimetidine for improvement of fluid secretion and electrolyte balance in patients with short bowel syndrome. (15532817)
2004
35
Intestinal rehabilitation and the short bowel syndrome: part 1. (15233682)
2004
36
Total parenteral nutrition, intestinal adaptation, and short bowel syndrome. (14990282)
2004
37
Fasting breath hydrogen concentration in short bowel syndrome patients with colon incontinuity before and after antibiotic therapy. (14962684)
2004
38
New and emerging therapies for short bowel syndrome in children. (12895135)
2003
39
Low-fat diet impairs postresection intestinal adaptation in a rat model of short bowel syndrome. (12891489)
2003
40
Indications for specific therapy in the rehabilitation of patients with the short-bowel syndrome. (14642856)
2003
41
Effects of enteral arginine supplementation on the structural intestinal adaptation in a rat model of short bowel syndrome. (12870793)
2003
42
Adverse effects of liver dysfunction and portal hypertension on intestinal adaptation in short bowel syndrome in children. (12488176)
2002
43
Does ileal reverse segment in rats with short bowel syndrome change intestinal morphology? (11840034)
2002
44
Effect of transforming growth factor-alpha on intestinal adaptation in a rat model of short bowel syndrome. (12505047)
2002
45
Pharmacotherapy and growth factors in the treatment of short bowel syndrome. (11329609)
2001
46
Treatment of short-bowel syndrome. (11706294)
2001
47
Severe convulsant hypomagnesaemia and short bowel syndrome. (11439801)
2001
48
Combination therapy with Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides dramatically improved the intestinal function in a girl with short bowel syndrome: a novel synbiotics therapy for intestinal failure. (11575457)
2001
49
Intestinal ornithine decarboxylase in short bowel syndrome patients with oral diet. (11327746)
2001
50
Warfarin resistance in a patient with short-bowel syndrome. (3614776)
1987

Variations for Short Bowel Syndrome

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Expression for genes affiliated with Short Bowel Syndrome

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Search GEO for disease gene expression data for Short Bowel Syndrome.

Pathways for genes affiliated with Short Bowel Syndrome

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Compounds for genes affiliated with Short Bowel Syndrome

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Compounds related to Short Bowel Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1enterogastrone439.9CCK, PYY
2taurodeoxycholate439.9CCK, SST
3minigastrin439.9CCK, SST
4vapreotide43 28 1211.8CCK, SST
5alosetron43 1210.8CCK, SST
6glipizide43 49 1211.8SST, DPP4
7bethanechol43 28 1211.8CCK, SST
8rimonabant43 28 1211.7DPP4, CCK
9cyproheptadine43 28 1211.7SST, CCK
10orlistat43 59 1211.5CCK, PYY
11intralipid439.5PYY, SST, CCK
12pirenzepine43 28 1211.5CCK, SST
13omeprazole43 49 28 24 1213.5SST, CCK, PYY
14cyclo(his-pro)439.5CCK, NTS
15pramlintide43 1210.5DPP4, CCK, PYY
16incretin439.5CCK, PYY, DPP4
17enterostatin439.4NTS, CCK
18loperamide43 24 1211.4SST, CCK
19alpha msh439.4CCK, NTS
20carbohydrates439.3DPP4, CCK, PYY
21clonidine43 49 28 1212.2SST, PYY, NTS
22loxiglumide439.1CCK, SST, NTS
23dtpa439.1NTS, SST, CCK
24tetrodotoxin43 59 2811.1CCK, PYY, NTS
25naloxone43 28 49 1212.1NTS, CCK, SST
26cocaine43 1210.1PYY, CCK, NTS
27isoproterenol43 1210.0PYY, SST, NTS
28phosphoramidon43 1210.0NTS, DPP4, CCK
29gnrh438.9PYY, NTS, SST
30carbon438.9NTS, CCK, DPP4
31benzodiazepine438.8NTS, CCK
32oxyntomodulin43 599.7PYY, NTS, CCK, SST
33amphetamine43 49 1210.7SST, PYY, CCK, NTS
34octreotide43 59 28 1211.7CCK, SST, NTS, PYY
35atropine43 28 1210.7CCK, SST, NTS, PYY
36carbachol43 28 1210.7NTS, PYY, SST, CCK
375-hydroxytryptamine438.7SST, NTS, CCK, PYY
38acth438.7PYY, CCK, SST, NTS
39gaba438.7NTS, CCK, SST, PYY
40norepinephrine43 24 1210.7NTS, PYY, SST, CCK
41histamine43 28 2410.7NTS, PYY, SST, CCK
42acetylcholine43 49 28 24 1212.7NTS, PYY, CCK, SST
43phenylalanine438.6FLNA, NTS, CCK
44adenylate438.5CCK, NTS, SST, DPP4
45arginine438.5SST, PYY, CCK, NTS
46glutamate438.3NTS, DPP4, CCK, SST
47c-peptide438.2NTS, SST, DPP4, CCK, PYY
48glucose438.1SST, CCK, PYY, NTS, DPP4
49dopamine43 28 24 1211.1PYY, CCK, NTS, FLNA, SST
50tyrosine437.8PYY, FLNA, CCK, NTS, DPP4

GO Terms for genes affiliated with Short Bowel Syndrome

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Cellular components related to Short Bowel Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.6NTS, CCK, SST, FLNA, PYY

Biological processes related to Short Bowel Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00075869.6SST, PYY
2eating behaviorGO:00427559.2CCK, PYY

Molecular functions related to Short Bowel Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.1CCK, SST, PYY
2neuropeptide hormone activityGO:00051848.4NTS, CCK, PYY

Products for genes affiliated with Short Bowel Syndrome

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Sources for Short Bowel Syndrome

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3CDC
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23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet