Short Bowel Syndrome malady

NIH Rare Diseases: Short bowel syndrome is a group of problems involving the small intestine that causes poor absorption of nutrients from food. The main cause of short bowel syndrome is surgical removal of half or more of the small intestine to treat intestinal diseases, injuries, or defects present at birth. Signs and symptoms may include diarrhea, cramping, bloating, heartburn, dehydration, malnutrition, weight loss, food sensitivities, weakness, and fatigue. Examples of treatment include diet and nutritional support, and in some cases intestinal transplantation.³⁰

MalaCards: Short Bowel Syndrome, also known as short bowel syndrome (disorder), is related to portal hypertension and intestinal pseudo-obstruction. An important gene associated with Short Bowel Syndrome is GCG (glucagon), and among its related pathways are ERK5 Signaling and Glioma Invasiveness. The compounds c-peptide and l-nmma have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and colon, and related mouse phenotypes are endocrine/exocrine gland and nervous system.

Wikipedia: Short bowel syndrome (SBS, also short gut syndrome or simply short gut) is a malabsorption disorder...⁴⁴ more...

Aliases & Descriptions:

short bowel syndrome 6 30 8 32 43 short bowel syndrome (disorder) 6

acquired short bowel syndrome 6 short gut syndrome 6

Diseases related to short bowel syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 578)

id	Related Disease	Score	Top Affiliating Genes
1	portal hypertension	29.1	F2, ALB, SST
2	intestinal pseudo-obstruction	28.3	ALB, TNF, SST
3	crohn's disease	27.9	GCG, FGF7, IL1B, IGES, TNF
4	celiac disease	23.7	LEP, CD79A, IL1B, CCK, IGF1, F3
5	hypertension	20.3	LEP, CD79A, CDH1, IL1B, IGF1, IGHE
6	steatorrhea	13.6	GCG, CCK, SST
7	dumping syndrome	13.6	GCG, PYY, SST, NTS
8	familial medullary thyroid carcinoma	13.6	SST, NTS, ABP1
9	microvillus inclusion disease	13.6	EGF, SI
10	endocrine gland cancer	13.5	GCG, SST, GAST
11	somatostatinoma	13.5	GCG, SST, GAST
12	pancreatic islet cell tumors	13.5	SST, NTS, GAST
13	pancreatic cholera	13.5	SST, GAST
14	duodenogastric reflux	13.5	CCK, PYY, NTS, GAST
15	apudoma	13.5	SST, GAST
16	constipation	13.4	CCK, PYY, SST, NTS
17	vipoma	13.4	GH1, SST, NTS, GAST
18	hereditary pancreatitis	13.4	GCG, CCK, IGES, SST, NTS
19	bulimia nervosa	13.4	LEP, CCK, PYY
20	chylous ascites	13.3	ALB, SST
21	atrophic gastritis	13.3	SST, ODC1, GAST
22	leptin deficiency	13.3	LEP, CCK, GH1
23	food allergy	13.3	IGES, IGHE, ABP1
24	thyroid medullary carcinoma	13.3	CDH1, SST, NTS, ABP1
25	glucagonoma	13.3	GCG, CCK, GH1, SST, GAST
26	pancreatic cancer	13.3	GCG, CCK, SST, GAST
27	wermer syndrome	13.3	PTH, SST, GAST
28	hirschsprung's disease	13.3	GCG, PYY, SST, SI
29	somatostatin analog, resistance to	13.3	IGF1, SST
30	laron dwarfism	13.3	IGF1, GH1
31	morbid obesity	13.3	GCG, LEP, CCK, PYY
32	hyper-ige syndrome	13.3	IGES, IGHE
33	adrenal gland hyperfunction	13.3	LEP, GH1, SST
34	exercise induced anaphylaxis	13.2	CD79A, IGHE
35	neuroendocrine carcinoma	13.2	GCG, CDH1, SST, GAST
36	acid-labile subunit	13.2	IGF1, GH1, EGF
37	prothrombin deficiency	13.2	F3, F2
38	teratoma	13.2	GCG, CDH1, GH1, SST, NTS
39	growth hormone secreting pituitary adenoma	13.2	IGF1, GH1, SST
40	pituitary gland disease	13.2	IGF1, GH1
41	factor vii deficiency	13.2	F3, F2, EGF
42	hemophilia b	13.2	F3, F2, EGF
43	eating disorder	13.1	LEP, CCK, PYY, NTS, DPP4
44	zollinger-ellison syndrome	13.1	CDH1, SST, NTS, EGF, GAST
45	pancreatic endocrine tumors	13.1	GCG, CDH1, SST, NTS, GAST
46	mccune albright syndrome	13.1	IGF1, GH1, SST
47	diabetic autonomic neuropathy	13.1	GCG, IGF1, ABP1, GAST
48	neuroendocrine tumor	13.1	GCG, CCK, GH1, PYY, SST, NTS
49	vericose veins	13.1	F2, ALB, SST
50	esophageal varix	13.1	F2, ALB, SST

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to short bowel syndrome:

²²

MGI Mouse Phenotypes related to short bowel syndrome:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.8	SLC9A3, DPP4, PTH, GLP2R
2	nervous system phenotype	MP:0003631	8.6	ABCB7, NTS, PYY, HPN, F2, F3
3	immune system phenotype	MP:0005387	8.2	GAST, SLC9A2, PTH, TNF, F2, FGF7
4	growth/size phenotype	MP:0005378	7.7	HGF, DPP4, ABCB7, EGF, NTS, SST
5	tumorigenesis	MP:0002006	7.0	TNF, GLP2R, F3, IGF1, IL1B, CDH1
6	digestive/alimentary phenotype	MP:0005381	6.7	EGF, SLC9A3, SLC15A1, SLC9A2, GAST, SST
7	homeostasis/metabolism phenotype	MP:0005376	3.4	GCG, GH1, TNF, PYY, SST, NTS

Articles related to short bowel syndrome:

(show all 49)

id	Title	Authors	Year	Affiliating Genes
1	The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. (20171649)	Cole C.R.... Ziegler T.R.	2010	IL1B
2	Growth factors: possible roles for clinical managemen t of the short bowel syndrome. (20123272)	McMellen M.E.... Warner B.W.	2010	LEP
3	Population pharmacokinetics of teduglutide following repeated subcutaneous administrations in healthy participants and in patients w ith short bowel syndrome and Crohn's disease. (19773525)	Marier J.F.... Wallens J.	2010	GCG
4	Morphological adaptation with preserved proliferation /transporter content in the colon of patients with short bowel syndrome. (19389806)	Joly F.... Thomas M.	2009	SLC9A3, SLC9A2, SLC15A1
5	Clinical trial simulations in pediatric patients usin g realistic covariates: application to teduglutide, a glucagon-like peptide-2 a nalog in neonates and infants with short-bowel syndrome. (19847163)	Mouksassi M.S.... Vinks A.A.	2009	GCG
6	Ghrelin does not predict adaptive hyperphagia in pati ents with short bowel syndrome. (19176401)	Compher C.W.... Metz D.C.	2009	PYY
7	Colonic GLP-2 is not sufficient to promote jejunal ad aptation in a PN-dependent rat model of human short bowel syndrome. (19644131)	Koopmann M.C.... Ney D.M.	2009	GCG, GLP2R
8	Short bowel syndrome: the role of GLP-2 on improving outcome. (19474717)	Wallis K.... Gabe S.	2009	GCG
9	Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. (19028932)	Compher C.W.... Metz D.C.	2009	PYY
10	Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome. (18609184)	Gottschalck I.B.... Henriksen D.B.	2008	GCG
11	GLP-2 administration results in increased proliferation but paradoxically an adverse outcome in a juvenile piglet model of short bowel syndrome. (18162829)	Pereira-Fantini P.M.... Bines J.E.	2008	GCG
12	Short bowel syndrome in the research setting: 15 years' experience (18624270)	GarcA-a-Urkia N.... Eizaguirre I.	2008	TNF
13	Frequent IgE sensitization to latex, cow's milk, and egg in children with short bowel syndrome. (17651378)	Mazon A.... Dalmau J.	2008	IGHE, IGES
14	The impact of longitudinal intestinal lengthening and tailoring on liver function in short bowel syndrome. (18704888)	Reinshagen K.... Waag K.L.	2008	ABCB7
15	Screening for celiac disease in short bowel syndrome. (18203966)	Keswani R.N.... Semrad C.E.	2008	CD79A
16	Chronically administered retinoic acid has trophic ef fects in the rat small intestine and promotes adaptation in a resection model o f short bowel syndrome. (17307727)	Wang L.... Levin M.S.	2007	CDH1
17	Growth hormone favorably affects bone turnover and bone mineral density in patients with short bowel syndrome undergoing intestinal rehabilitation. (17047171)	Tangpricha V.... Ziegler T.R.	2006	PTH
18	Dietary and medical management of short bowel syndrom e in adult patients. (16770167)	Matarese L.E.... Steiger E.	2006	SST
19	Gut hormones, and short bowel syndrome: the enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation. (16830359)	Martin G.R.... Sigalet D.L.	2006	GCG, GLP2R
20	Teduglutide for the treatment of short bowel syndrome. (16705029)	Ferrone M.... Scolapio J.S.	2006	GCG
21	Short bowel syndrome and intestinal failure: consensu s definitions and overview. (16431298)	O'Keefe S.J.... Shaffer J.	2006	GCG
22	The use of hormonal growth factors in the treatment of patients with short-bowel syndrome. (16620138)	Jeppesen P.B.	2006	GCG
23	Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. (16099790)	Jeppesen P.B.... Mortensen P.B.	2005	GCG
24	Dipeptidyl-peptidase IV in patients with short bowel syndrome. (16169633)	Farriol M.... Delgado G.	2005	DPP4
25	A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome. (15937810)	Sigalet D.L.... Meddings J.B.	2005	EGF
26	Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome. (15388486)	Martin G.R.... Sigalet D.L.	2005	GCG
27	Current update of short-bowel syndrome. (15703636)	Scolapio J.S.	2004	GCG
28	Use of clonidine to decrease intestinal fluid losses in patients with high-output short-bowel syndrome. (15291409)	McDoniel K.... Klein S.	2004	SST
29	Clinical significance of GLP-2 in short-bowel syndrome. (14608103)	Jeppesen P.B.	2003	GCG
30	IGF-I treatment facilitates transition from parenteral to enteral nutrition in rats with short bowel syndrome. (12388469)	Gillingham M.B.... Ney D.M.	2003	SI
31	Adverse effects of liver dysfunction and portal hypertension on intestinal adaptation in short bowel syndrome in children. (12488176)	Weber T.R.... Keller M.S.	2002	F2
32	Nutritional management of short bowel syndrome. (12230319)	Ukleja A.... Buchman A.L.	2002	GCG
33	Epidermal growth factor improves nutritional outcome in a rat model of short bowel syndrome. (11987096)	Sham J.... Sigalet D.L.	2002	EGF
34	Enhancing bowel adaptation in short bowel syndrome. (12149180)	Jeppesen P.B.... Mortensen P.B.	2002	GCG
35	Distribution of the H+/peptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. (11976168)	Ziegler T.R.... Leader L.M.	2002	SLC15A1
36	Treatment of short-bowel syndrome. (11706294)	Scolapio J.S.	2001	GCG
37	Cholecystokinin (CCK) secretion in patients with seve re short bowel syndrome (SSBS). (11330425)	Ling P.R.... Bistrian B.R.	2001	CCK
38	Intestinal ornithine decarboxylase in short bowel syndrome patients with oral diet. (11327746)	Segovia-Silvestre T.... Farriol M.	2001	ODC1
39	Nutritional effects of surgical and medical treatment for short bowel syndrome. (11688937)	Sigalet D.L.... Van Aerde J.	2001	SLC5A2
40	Keratinocyte growth factor enhances early gut adaptation in a rat model of short bowel syndrome. (10653491)	Johnson W.F.... Farrell C.L.	2000	FGF7
41	Serum leptin concentrations in patients with short-bowel syndrome. (11031071)	Molina A.... GA^mez J.M.	2000	LEP
42	Epidermal growth factor and the short bowel syndrome. (10483910)	Thompson J.S.	1999	EGF
43	Clinical use of growth hormone and glutamine in short bowel syndrome. (10488599)	Cukier C.... Pinotti H.W.	1999	GH1
44	Enteral and parenteral nutrition in patients with short-bowel syndrome. (10532260)	Vanderhoof J.A.... Matya S.M.	1999	GAST
45	Enteral glutamine does not enhance the effects of hepatocyte growth factor in short bowel syndrome. (9856891)	Alavi K.... Schwartz M.Z.	1998	HGF
46	Gastrointestinal hormones in short bowel syndrome. Peptide YY may be the 'colonic brake' to gastric emptying. (8977342)	Nightingale J.M.... Lennard-Jones J.E.	1996	SST
47	Somatostatin and its analogs in the short bowel syndrome. (1363486)	Rosen G.H.	1992	SST
48	Human gut hormone profiles in patients with short bowel syndrome. (1563315)	Andrews N.J.... Irving M.H.	1992	PYY
49	Oral anticoagulation in patients with short-bowel syndrome. (2113745)	Owens J.P.... Murphy C.C.	1990	F2, F3

Genes related to short bowel syndrome according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	GCG	glucagon	11.0	Publications
2	PYY	peptide YY	11.0	Publications
3	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0
4	FGF7	fibroblast growth factor 7	11.0	Publications
5	NTS	neurotensin	11.0
6	CCK	cholecystokinin	11.0	Publications
7	SST	somatostatin	11.0	Publications
8	DPP4	dipeptidyl-peptidase 4	11.0	Publications
9	EGF	epidermal growth factor	11.0	Publications
10	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
11	GH1	growth hormone 1	11.0	Publications
12	SLC5A2	solute carrier family 5 (sodium/glucose cotransporter), member 2	11.0	Publications
13	GLP2R	glucagon-like peptide 2 receptor	11.0	Publications
14	IGES	immunoglobulin E concentration, serum	11.0	Publications
15	TNNC1	troponin C type 1 (slow)	11.0
16	SLC15A1	solute carrier family 15 (oligopeptide transporter), member 1	11.0	Publications
17	HPN	hepsin	11.0
18	PTH	parathyroid hormone	11.0	Publications
19	SI	sucrase-isomaltase (alpha-glucosidase)	11.0	Publications
20	SLC9A2	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	11.0	Publications
21	SLC9A3	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	11.0	Publications
22	LPGAT1	lysophosphatidylglycerol acyltransferase 1	11.0
23	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
24	GAST	gastrin	11.0	Publications
25	ODC1	ornithine decarboxylase 1	11.0	Publications
26	F2	coagulation factor II (thrombin)	11.0	Publications
27	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	11.0	Publications
28	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
29	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
30	LEP	leptin	11.0	Publications
31	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
32	IL1B	interleukin 1, beta	11.0	Publications
33	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0
34	TNF	tumor necrosis factor	11.0	Publications
35	ALB	albumin	11.0

Pathways related to short bowel syndrome according to GeneDecks:

(show all 44)

id	Pathway	Score	Top Affiliating Genes
1	ERK5 Signaling36	10.4	GH1, HGF
2	Glioma Invasiveness36	10.4	HGF, GH1, FGF7
3	Epithelial Adherens Junctions36	10.0	CDH1, FGF7, GH1, HGF
4	Molecular Mechanisms of Cancer36	10.0	CDH1, GH1, EGF, HGF
5	ERK Signaling36	9.9	FGF7, IL1B, EGF
6	Akt Signaling36	9.7	HGF, TNF, FGF7
7	Actin-Based Motility by Rho Family GTPases36	9.6	FGF7, IGF1, GH1
8	p53 Mediated Apoptosis36	9.6	FGF7, IGF1, GH1, EGF, HGF
9	Mitochondrial Apoptosis36	9.6	HGF, EGF, GH1, IGF1, FGF7
10	Melanoma20	9.5	HGF, EGF, IGF1, FGF7, CDH1
11	mTOR Pathway36	9.5	HGF, EGF, GH1, IGF1, FGF7
12	eIF2 Pathway36	9.5	HGF, EGF, GH1, IGF1, FGF7
13	Nanog in Mammalian ESC Pluripotency36	9.5	HGF, EGF, GH1, IGF1, FGF7
14	Paxillin Interactions36	9.4	FGF7, IGF1, GH1, EGF
15	Nuclear Receptor Activation by Vitamin-A36	9.4	HGF, EGF, GH1, IGF1, FGF7
16	Rac1 Pathway36	9.4	HGF, EGF, GH1, IGF1, FGF7
17	p70S6K Signaling36	9.4	HGF, EGF, GH1, F2, IGF1, FGF7
18	IP3 Pathway36	9.3	HGF, EGF, GH1, IGF1, FGF7, CD79A
19	NFAT in Immune Response36	9.3	HGF, EGF, GH1, IGF1, FGF7, CD79A
20	GSK3 Signaling36	9.3	HGF, EGF, GH1, IGF1, FGF7, CDH1
21	Intracellular Calcium Signaling36	9.2	HGF, SLC9A2, SLC9A3, EGF, GH1, IGF1
22	DHA Signaling36	9.2	HGF, EGF, GH1, IGF1, IL1B, FGF7
23	Activation of PKC through GPCR36	9.2	HGF, EGF, GH1, IGF1, FGF7
24	PPAR Pathway36	9.2	TNF, GH1, IGF1, FGF7
25	14-3-3 Induced Intracellular Signaling36	9.1	FGF7, IGF1, GH1, TNF
26	G12-G13 in Cellular Signaling36	9.1	SLC9A2, SLC9A3, F2, CDH1
27	Rho Family GTPases36	9.0	HGF, GH1, IGF1, IL1B, FGF7, CDH1
28	Phospholipase-C Pathway36	8.9	HGF, EGF, GH1, IGF1, FGF7, CD79A
29	Apoptotic Pathways in Synovial Fibroblasts36	8.9	HGF, EGF, TNF, GH1, IGF1, FGF7
30	Cellular Apoptosis Pathway36	8.9	HGF, EGF, TNF, GH1, IGF1, FGF7
31	TGF-Beta Pathway36	8.9	HGF, EGF, GH1, IGF1, IL1B, FGF7
32	JAK-STAT Pathway36	8.9	HGF, EGF, GH1, F2, IGF1, IL1B
33	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.7	IL1B, IGF1, TNF, PTH
34	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.7	PTH, TNF, IGF1, IL1B
35	Cytokine-cytokine receptor interaction20	8.6	HGF, EGF, TNF, GH1, IL1B, LEP
36	ILK Signaling36	8.5	HGF, EGF, TNF, GH1, IGF1, FGF7
37	NF-KappaB (p50-p65) Pathway36	8.4	FGF7, HGF, EGF, TNF, GH1, IGF1
38	PAK Pathway36	8.4	HGF, TNF, GH1, IGF1, IL1B, FGF7
39	NF-KappaB Family Pathway36	8.4	HGF, EGF, TNF, GH1, IGF1, IL1B
40	MAPK Family Pathway36	8.4	HGF, EGF, TNF, GH1, IGF1, IL1B
41	Tec Kinases Signaling36	8.3	HGF, EGF, TNF, GH1, IGF1, IL1B
42	Antioxidant Action of Vitamin-C36	8.3	HGF, EGF, TNF, GH1, IGF1, IL1B
43	p38 Signaling36	8.3	HGF, EGF, TNF, GH1, IGF1, IL1B
44	MAPK Signaling36	8.3	HGF, EGF, TNF, GH1, IGF1, IL1B

Compounds related to short bowel syndrome according to GeneDecks:

(show top 50)    (show all 259)

id	Compound	Score	Top Affiliating Genes
1	c-peptide32	10.1	DPP4, CCK, LEP, GCG
2	l-nmma32	10.1	IGHE, CCK, GH1
3	carbachol32 9 9	12.0	GAST, SST, PTH, CCK, GCG
4	carbohydrates32	9.7	ODC1, DPP4, CDH1, SI, CCK, PYY
5	glucose32	9.6	GCG, PTH, NTS, SLC5A2, GAST, SLC9A3
6	oxyntomodulin32 42	10.6	PYY, NTS, GAST, SST, CCK, LEP
7	pirenzepine32 9 9	11.3	SST, GH1, IGF1, GCG, CCK, GAST
8	dopamine32 9 18 9	12.3	GCG, ABP1, PYY, GH1, CCK, NTS
9	dtpa32	9.2	NTS, GAST, ALB, GCG, CCK, SST
10	pge232	9.2	CCK, SST, NTS, EGF, FGF7, CDH1
11	octreotide32 42 9 9	12.1	PYY, SST, NTS, EGF, GAST, GH1
12	aspartate32	9.0	NTS, HGF, GH1, SI, DPP4, ABCB7
13	gnrh32	8.8	GH1, GCG, LEP, IGF1, EGF, NTS
14	bicarbonate32	8.7	ALB, NTS, PTH, SLC9A2, SLC9A3, GAST
15	clonidine32 9 9	10.6	GH1, SLC15A1, LEP, IGF1, PYY, SST
16	isoproterenol32 9 9	10.6	SST, NTS, GCG, IGHE, GAST, GH1
17	ibmx32	8.5	GCG, EGF, IGF1, SST, PTH, CCK
18	norepinephrine32 9 18 9	11.3	SST, IGHE, GCG, LEP, HGF, NTS
19	acetylcholine32 9 18 9	11.3	CCK, SST, PYY, GH1, IGES, GAST
20	acth32	8.3	SST, PYY, IGF1, CCK, IL1B, LEP
21	arginine32	8.2	SI, SLC5A2, ABP1, NTS, SST, PTH
22	epinephrine32 9 18 9	11.2	F2, F3, GAST, IGHE, GCG, NTS
23	sodium32 18	9.2	SI, ABP1, ABCB7, PTH, ALB, FGF7
24	glutamate32	8.1	GCG, CDH1, IGHE, SST, ODC1, NTS
25	testosterone32 9 18 9	11.0	HGF, ODC1, PTH, IGHE, CCK, FGF7
26	adenylate32	7.9	NTS, EGF, SST, ODC1, DPP4, SLC9A3
27	vegf32	7.9	FGF7, GAST, GCG, IGF1, HGF, F3
28	heparin32 9 18 9	10.6	GAST, HGF, DPP4, ABP1, ABCB7, EGF
29	glutamine32	7.6	GH1, ODC1, EGF, ABP1, SLC9A3, SI
30	alanine32	7.5	DPP4, GCG, ABCB7, GLP2R, ALB, F3
31	thyroxine32 18	8.4	SST, PTH, NTS, ABCB7, GAST, GH1
32	cyclosporin a32 42	8.3	IGHE, SLC15A1, IGES, CCK, FGF7, F2
33	butyrate32	7.3	SI, EGF, SLC9A2, SLC9A3, GCG, LEP
34	pd 98,05932	7.2	IGF1, LEP, TNF, GCG, EGF, GH1
35	genistein32 9 18 9	10.2	SLC9A3, IL1B, CDH1, GCG, IGF1, GH1
36	thymidine32 18	8.1	TNF, HGF, GAST, EGF, NTS, ODC1
37	hydrocortisone32 9 9	9.1	FGF7, IL1B, GAST, HGF, SI, SLC9A3
38	sb 20358032 42	8.1	CDH1, IL1B, IGF1, F3, GH1, TNF
39	creatinine32	7.0	HGF, SLC9A3, DPP4, ABP1, ABCB7, PTH
40	calcitriol32 42 9 18 9	10.9	ALB, GH1, PTH, IGF1, EGF, GAST
41	indomethacin32 9 9	8.8	EGF, LEP, CD79A, CDH1, IL1B, NTS
42	actinomycin d32	6.7	TNF, IL1B, HGF, IGF1, SLC9A3, EGF
43	estrogen32	6.6	GCG, LEP, CD79A, CDH1, PTH, FGF7
44	methotrexate32 34 42 9 9	10.3	HGF, SI, DPP4, ODC1, TNF, GH1
45	histamine32 18	7.2	GAST, GCG, CD79A, CDH1, HGF, ABP1
46	lactate32	6.2	HGF, GCG, CD79A, CDH1, SI, SLC9A3
47	cycloheximide32	6.0	FGF7, LEP, GCG, IL1B, IGHE, EGF
48	retinoic acid32 42 18	7.9	IL1B, IGF1, F3, IGHE, CCK, GH1
49	serine32	5.8	HGF, GAST, SLC9A3, GH1, DPP4, LEP
50	dexamethasone32 42 34 9 9	9.5	EGF, NTS, SST, PTH, TNF, GH1

Cellular components related to short bowel syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	8.7	HGF, EGF, ALB, IGF1
2	plasma membrane	GO:005886	6.4	SLC9A2, SLC15A1, SLC9A3, SLC5A2, DPP4, ABP1
3	extracellular region	GO:005576	6.2	PTH, SST, NTS, EGF, DPP4, HGF
4	extracellular space	GO:005615	5.5	GCG, HGF, ABP1, EGF, SST, PTH

Biological processes related to short bowel syndrome according to GeneDecks:

(show all 22)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of protein localization to cell surface	GO:2000008	10.2	EGF, CDH1
2	negative regulation of appetite	GO:032099	10.2	GCG, LEP, CCK
3	eating behavior	GO:042755	10.1	PYY, CCK, LEP
4	positive regulation of cerebellar granule cell precursor proliferation	GO:021940	9.9	EGF, IGF1
5	induction of apoptosis by hormones	GO:008628	9.8	SST, PTH
6	myoblast proliferation	GO:051450	9.7	HGF, IGF1
7	bone mineralization involved in bone maturation	GO:035630	9.6	IGF1, LEP
8	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	HGF, GH1, IGF1, CCK, FGF7
9	regulation of branching involved in salivary gland morphogenesis	GO:060693	9.6	CDH1, TNF
10	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.6	IGF1, F2, GH1, HGF
11	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.4	TNF, IL1B
12	positive regulation of MAP kinase activity	GO:043406	9.4	GH1, TNF, EGF
13	sequestering of triglyceride	GO:030730	9.3	TNF, IL1B
14	platelet degranulation	GO:002576	9.3	IGF1, ALB, EGF, HGF
15	chronic inflammatory response to antigenic stimulus	GO:002439	9.2	TNF, IL1B
16	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.0	TNF, IL1B
17	response to glucocorticoid stimulus	GO:051384	9.0	SI, SLC9A3, TNF, IL1B
18	regulation of insulin secretion	GO:050796	8.9	GCG, LEP, IL1B, TNF
19	platelet activation	GO:030168	8.8	HGF, EGF, ALB, F2, IGF1
20	positive regulation of mitosis	GO:045840	8.7	EGF, TNF, IGF1, IL1B
21	positive regulation of cell proliferation	GO:008284	8.5	LEP, DPP4, EGF, ODC1, GLP2R, F2
22	anti-apoptosis	GO:006916	8.2	HGF, TNF, F3, IGF1, IL1B

Molecular functions related to short bowel syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	10.1	CCK, PYY, NTS
2	hormone activity	GO:005179	8.2	GCG, GAST, SST, PTH, PYY, GH1
3	growth factor activity	GO:008083	7.7	HGF, EGF, GH1, F2, IGF1, IL1B