Short Stature malady

Wikipedia: Short stature refers to a height of a human being which is below expected. Shortness is a vague term...⁴⁴ more...

MalaCards: Short Stature is related to turner syndrome and growth hormone deficiency. An important gene associated with Short Stature is SHOX (short stature homeobox), and among its related pathways are Activation of cAMP-Dependent PKA and Renin-Angiotensin Pathway. The compounds alanine and arginine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, kidney and thyroid, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

OMIM: 604271

short stature 7 33 32

Diseases related to short stature by text searches and GeneDecks gene sharing:

(show top 50)    (show all 783)

id	Related Disease	Score	Top Affiliating Genes
1	turner syndrome	34.8	BGLAP, IGFBP1, IGFBP3, IGF1, GH1, GHR
2	growth hormone deficiency	34.2	REN, PBX1, BGLAP, LHX3, LHX4, LEP
3	leri-weill dyschondrosteosis	34.0	LBX1, FGFR3, SHOX
4	noonan syndrome	33.3	BRAF, RAF1, FGFR3, MAP2K2, MAP2K1, IGFBP3
5	dwarfism	33.2	LHX3, CDT1, CDC6, ARSE, INS, FGFR3
6	microcephaly	32.9	ZNF592, RENS2, VPS13B, RBM28, RAD50, ZBTB16
7	meier-gorlin syndrome	32.7	LMX1B, BMP5, CDT1, CDC6, SHOX, ORC4
8	prader-willi syndrome	32.7	LEP, CFI, FMR1, INS, MAGEL2, IGFBP1
9	mental retardation syndrome	32.1	KDM5C, ATRX, MRSS, MRXSA, FMR1, CUL4B
10	schimke immunoosseous dysplasia	31.9	B3GAT3, CFI, GNPTAB, GNPTG, CTSK, PLOD2
11	isolated growth hormone deficiency	31.8	LHX4, IGF1, GH1, GHRH, GHRHR, GHSR
12	laron syndrome	31.7	INS, IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1
13	delayed puberty	31.7	LEP, IGFBP3, IGF1, GNRH1, GHR, GHRH
14	multiple epiphyseal dysplasia	31.4	CD36, MATN3, COL9A2, COMP, COL9A3, COL2A1
15	costello syndrome	31.4	BRAF, INS, MAP2K2, MAP2K1, IGF2, IGFBP3
16	achondroplasia	31.3	FGFR3, MAP2K1, IHH, IGF1, PTHLH, COL1A1
17	leopard syndrome	31.1	BRAF, RAF1, FBN1, MAP2K2, MAP2K1, HRAS
18	photosensitive trichothiodystrophy	31.0	PBX1, BGLAP, LEP, CFI, CD36, INS
19	11-beta-hydroxylase deficiency	30.9	REN, GH1, CYP21A2, SHBG
20	cartilage-hair hypoplasia	30.8	TRPS1, RPS19, COL10A1, RMRP
21	intellectual disability	30.8	VPS13B, RAI1, KDM5C, ATRX, FMR1, ARSE
22	combined pituitary hormone deficiency	30.4	RBM28, PBX1, LHX3, LHX4, INS, IGFBP3
23	brachydactyly	30.4	WDR35, REN, BMPR1B, PARK7, PAPSS2, CHST3
24	panhypopituitarism	30.2	BGLAP, LHX3, LHX4, IGFBP1, IGF2, IGF1
25	celiac disease	30.2	VDR, BGLAP, PARK7, LEP, CD36, FLNB
26	cerebellar hypoplasia	30.2	RECQL4, LHX3, GNAS, HOXD13, GH1, GHRH
27	hypoglycemia	30.1	LEP, CFI, CD36, INS, IGFBP1, IGF1R
28	silver-russell syndrome	30.1	IGFBP1, IGF1R, IGF2, IGFBP3, IGF1, COL1A2
29	empty sella syndrome	30.1	LHX3, IGF1, GH1, PRL, PROP1, POU1F1
30	anophthalmia	30.0	LHX4, INS, SRY, HESX1, PRL, SOX3
31	x-linked spondyloepiphyseal dysplasia tarda	30.0	CHST3, FGFR3, IGF1, TRPV4, COL1A1, COMP
32	pseudoachondroplasia	29.9	CD36, MATN3, COL9A2, COMP, COL9A3, COL9A1
33	robinow syndrome	29.9	IGF1, GNRH1, GH1, ROR2
34	amenorrhea	29.9	BGLAP, LEP, FMR1, AR, INS, IGFBP3
35	diastrophic dysplasia	29.8	PAPSS2, MATN3, COL9A2, COMP, COL9A3, COL2A1
36	azoospermia	29.8	PBX1, AR, IGF1, GNRH1, GJA1, GH1
37	laron dwarfism	29.7	IGF1, GH1, GHR
38	combined immunodeficiency	29.7	RECQL4, FMR1, AR, INS, IL2RG, IGFBP1
39	osteochondritis dissecans	29.7	CD36, MMP13, MATN3, COL9A2, COL9A3, COL9A1
40	severe combined immunodeficiency	29.7	FMR1, AR, INS, IL2RG, IGFBP1, IGFBP2
41	hypospadias	29.7	FMR1, AR, ALDH3A2, HOXA13, HOXD13, CYP21A2
42	glaucoma	29.6	REN, LMX1B, BMP5, MRXSA, MMP9, FBN1
43	chondrodysplasia	29.5	BMPR1B, CHST3, CD36, FLNB, ARSE, ARSB
44	werner syndrome	29.5	RECQL4, RAD50, BGLAP, ATRX, INS, IGFBP3
45	ichthyosis	29.5	BRAF, ARSE, ARSB, MAP2K2, MAP2K1, ALDH3A2
46	chst3-related skeletal dysplasia	29.5	MMP13, FLNB, FGFR3, GNAS, PTHLH, CTSK
47	diamond-blackfan anemia	29.5	RPS26, RPL35A, RPS17, RPS24, RPS7, RPL5
48	weill-marchesani syndrome	29.4	FBN1, LTBP3, ADAMTS10, ADAMTS17, ADAMTSL2
49	x-linked hypophosphatemia	29.4	BGLAP, FGF23, GH1
50	insulin resistance	29.4	REN, VLDLR, VDR, PBX1, BGLAP, LEP

Clinical features from OMIM: 604271

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to short stature:

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MGI Mouse Phenotypes related to short stature:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	INF	, RECQL4, REN, , VLDLR, BRAF
2	homeostasis/metabolism phenotype	MP:0005376	INF	REN, VLDLR, BRAF, VDR, LMX1B, RAF1
3	growth/size phenotype	MP:0005378	INF	RECQL4, REN, VLDLR, BRAF, VDR,
4	immune system phenotype	MP:0005387	INF	RECQL4, REN, BRAF, VDR, BMP5, RAD50
5	hematopoietic system phenotype	MP:0005397	INF	RECQL4, BRAF, RAD50, ZBTB16, CHST3, ARSB
6	digestive/alimentary phenotype	MP:0005381	INF	, RECQL4, BRAF, VDR, , BMP5
7	nervous system phenotype	MP:0003631	INF	, REN, VLDLR, BRAF, LMX1B, BMPR1B
8	reproductive system phenotype	MP:0005389	INF	REN, VDR, BMPR1B, RAD50, PBX1, LHX3
9	no phenotypic analysis	MP:0003012	INF	, LMX1B, INS, FGFR3, FBN1, IHH
10	cardiovascular system phenotype	MP:0005385	INF	REN, VLDLR, BRAF, VDR, LMX1B,
11	renal/urinary system phenotype	MP:0005367	INF	REN, BRAF, LMX1B, BMP5, PBX1, CFI
12	normal phenotype	MP:0002873	INF	REN, BRAF, LMX1B, PBX1, KDM5C, LBX1
13	muscle phenotype	MP:0005369	INF	, REN, BRAF, LMX1B, RAF1, LEP
14	adipose tissue phenotype	MP:0005375	INF	VLDLR, BRAF, RAI1, LEP, LEPRE1, CD36
15	vision/eye phenotype	MP:0005391	INF	, RECQL4, VLDLR, BRAF, LMX1B, BMPR1B
16	integument phenotype	MP:0010771	INF	RECQL4, BRAF, LMX1B, RAF1, PBX1, LEPRE1
17	endocrine/exocrine gland phenotype	MP:0005379	INF	BMP5, BMPR1B, RAD50, LHX3, LHX4, ZBTB16
18	cellular phenotype	MP:0005384	INF	, RECQL4, , VLDLR, BRAF, VDR
19	limbs/digits/tail phenotype	MP:0005371	INF	, RECQL4, VDR, LMX1B, BMP5, BMPR1B
20	skeleton phenotype	MP:0005390	INF	, BRAF, VDR, LMX1B, , BMPR1B
21	hearing/vestibular/ear phenotype	MP:0005377	INF	, VDR, BMP5, PBX1, LHX3, ARSB
22	liver/biliary system phenotype	MP:0005370	INF	BMP5, RAD50, PBX1, CD36, AR, INS
23	craniofacial phenotype	MP:0005382	INF	, RECQL4, LMX1B, , BMP5, BMPR1B
24	respiratory system phenotype	MP:0005388	INF	BMP5, RAD50, RAI1, LHX4, ARSB, FGF23
25	tumorigenesis	MP:0002006	INF	RECQL4, BRAF, RAD50, LEP, MMP9, AR
26	embryogenesis phenotype	MP:0005380	INF	, RECQL4, , BRAF, , BMP5
27	behavior/neurological phenotype	MP:0005386	INF	REN, VLDLR, BRAF, LMX1B, BMP5, RAD50
28	pigmentation phenotype	MP:0001186	INF	RECQL4, VLDLR, BRAF, BMPR1B, FBN1, CASR

Articles related to short stature:

(show top 50)    (show all 249)

id	Title	Authors	Year	Affiliating Genes
1	SHOX gene defects and selected dysmorphic signs in pa tients of idiopathic short stature and LAcri-Weill dyschondrosteosis. (22020182)	Hirschfeldova K.... Stekrova J.	2012	SHOX
2	Molecular mechanisms underlying insulin-like growth f actor action: How mutations in the GH: IGF axis lead to short stature. (21972777)	Forbes B.E.	2011	IGF1R, IGF1
3	A syndrome of short stature, microcephaly and speech delay is associated with duplications reciprocal to the common Sotos syndrome d eletion. (19844260)	Franco L.M.... Cheung S.W.	2010	NSD1
4	The role of insulin like growth factor (IGF)-1 and IG F-binding protein-3 in diagnosis of Growth Hormone Deficiency in short stature children. (19381505)	Haghshenas Z.... Amirhakimi G.	2009	IGF1, IGFBP3, INS
5	Noonan syndrome, the Ras-MAPK signalling pathway and short stature. (19407499)	Binder G.	2009	IGF1, PTPN11, IGFBP3
6	Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay. (19240156)	Fang P.... Rosenfeld R.G.	2009	IGF1R
7	Selecting short-statured children needing growth hormone testing: derivation and validation of a clinical decision rule. (18631396)	Duche L.... Chalumeau M.	2008	IGF1, GH1
8	Short stature and metaphyeal dysplasia due to cartilage-hair hypoplasia. (18540246)	Conwell L.S.... Zankl A.	2008	RMRP
9	OTX2 mutation in a patient with anophthalmia, short stature, and partial growth hormone deficiency: functional studies using the IRBP, HESX1, and POU1F1 promoters. (18628516)	Dateki S.... Ogata T.	2008	INS, POU1F1, HESX1
10	Treatment of short stature and growth hormone deficie ncy in children with somatotropin (rDNA origin). (19707446)	Hardin D.S.	2008	IGF1
11	Growth hormone treatment in adolescent males with idiopathic short stature: changes in body composition, protein, fat, and glucose metabolism. (17519313)	Hannon T.S.... Arslanian S.A.	2007	INS, GH1
12	Growth hormone is effective in treatment of short stature associated with short stature homeobox-containing gene deficiency: Two-year results of a randomized, controlled, multicenter trial. (17047016)	Blum W.F.... Rappold G.	2007	SHOX
13	Growth hormone insensitivity and severe short stature in siblings: a novel mutation at the exon 13-intron 13 junction of the STAT5b gene. (17389811)	Hwa V.... Rosenfeld R.G.	2007	IGF1, IGFBP3, GHR
14	Serum procollagen type 1 amino-terminal propeptide (P1NP) as an early predictor of the growth response to growth hormone treatment: Comparison of intrauterine growth retardation and idiopathic short stature. (17321775)	Gascoin-Lachambre G.... Souberbielle J.C.	2007	GH1
15	Genotypes and phenotypes in children with short stature: clinical indicators of SHOX haploinsufficiency. (17182655)	Rappold G.... Niesler B.	2007	SHOX
16	Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. (16801590)	Asao K.... Brancati F.L.	2006	INS
17	A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general population. (16498234)	Takahashi I.... Koizumi A.	2006	PTPN11
18	Genetic basis of short stature. (16114273)	Castro-Feijoo L.... Pombo M.	2005	LHX3, LHX4, HESX1
19	Short stature caused by a biologically inactive mutant growth hormone (GH-C53S). (15713716)	Besson A.... Mullis P.E.	2005	CSH1, GH1
20	X-linked mental retardation, short stature, microcephaly and hypogonadism maps to Xp22.1-p21.3 in a Belgian family. (16053905)	Van Esch H.... Devriendt K.	2005	DLG3
21	Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS). (16039893)	Park P.... Cohen P.	2005	IGF1
22	Evaluation of insulin-like growth factor (IGF)-I and IGF binding protein-3 generation test in short stature. (15921173)	Darendeliler F.... BaA9 F.	2005	IGF1, IGFBP3, GH1
23	Use of aromatase inhibitors in children with short stature. (16429098)	Cernich J.... Popovic J.	2004	CYP19A1
24	Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature. (12655557)	Millar D.S.... Procter A.M.	2003	CSH1, GH1
25	A familial Xp+ chromosome detected during fetal karyotyping, which is associated with short stature in four generations of a Turkish family. (12673642)	Karaman B.... Basaran S.	2003	SHOX
26	Auxology is a valuable instrument for the clinical diagnosis of SHOX haploinsufficiency in school-age children with unexplained short stature. (14557470)	Binder G.... Martin D.D.	2003	SHOX
27	Truncated growth hormone receptor mutations function as dominant-negative inhibitors of the full-length receptor and cause genetic short stature (11857919)	Minamitani K.	2002	GHR
28	SHOX intragenic microsatellite analysis in patients with short stature. (11874178)	Ezquieta B.... Gracia R.	2002	SHOX
29	The effect of short- and long-term growth hormone treatment on bone mineral density and bone metabolism of prepubertal children with idiopathic short stature: a 3-year study. (12460321)	Lanes R.... Weisinger J.R.	2002	GH1
30	Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature. (11889216)	Rappold G.A.... Ogata T.	2002	SHOX
31	Analysis of short stature homeobox-containing gene ( SHOX) and auxological phenotype in dyschondrosteosis and isolated Madelung deformity. (11735031)	Grigelioniene G.... Dumanski J.P.	2001	SHOX
32	SHOX gene in Leri-Weill syndrome and in idiopathic short stature. (11716161)	Bernasconi S.... Forabosco A.	2001	SHOX
33	Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. (11567216)	Machinis K.... Amselem S.	2001	PDLIM5, LHX4
34	Short stature homeobox-containing gene deletion screening by fluorescence in situ hybridisation in patients with short stature. (11585080)	Musebeck J.... Stumm M.	2001	SHOX
35	The usefulness of serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) for evaluation of children with short stature. (10932487)	Jaruratanasirikul S.... Sriplung H.	2000	IGF1, IGFBP3
36	Genetic studies in idiopathic short stature. (10943824)	Attie K.M.	2000	SHOX
37	Analysis of the intracellular signalling domain of the human growth hormone receptor in children with idiopathic short stature. (10762289)	Johnston L.B.... Clark A.J.	2000	GHR
38	Autosomal dominant hypoparathyroidism associated with short stature and premature osteoarthritis. (10487661)	Stock J.L.... Mericq M.V.	1999	CASR, CXADR
39	New growth hormone receptor exon 9 mutation causes genetic short stature. (10102075)	Ayling R.M.... Norman M.R.	1999	GHR
40	Long-term zinc and iron supplementation in children of short stature: effect of growth and on trace element content in tissues. (10445218)	Perrone L.... Di Toro R.	1999	TF
41	Preliminary report on the short stature of Southeast Asian forest dwellers, the Manni, in southern Thailand: lack of an adolescent spurt in plasma IGF-I concentration. (9740270)	Ishida T.... Settheetham-Ishida W.	1998	IGF1
42	Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. (9140395)	Rao E.... Rappold G.A.	1997	SHOX
43	Short stature and failure of pubertal development in thalassaemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion. (9365067)	Roth C.... SchrAPter W.	1997	IGF1
44	Partial growth-hormone insensitivity: the role of growth-hormone receptor mutations in idiopathic short stature. (9255229)	Goddard A.D.... Attie K.	1997	GHR
45	Insulin-like growth factor I gene deletion causing in trauterine growth retardation and severe short stature. (9401537)	Woods K.A.... Savage M.O.	1997	IGF1
46	Short stature caused by a mutant growth hormone. (8552145)	Takahashi Y.... Chihara K.	1996	CSH1, GH1
47	Growth hormone (GH)-releasing effects of synthetic peptide GH-releasing peptide-2 and GH-releasing hormone (1-29NH2) in children with GH insufficiency and idiopathic short stature. (7666796)	Tuilpakov A.N.... Bowers C.Y.	1995	GHSR, GH1
48	Insulin-like growth factor-I in children with short stature. (7735013)	Tsai W.Y.... Lee J.S.	1994	IGF1
49	Constitutionally short stature: analysis of the insulin-like growth factor-I gene and the human growth hormone gene cluster. (1677176)	Mullis P.E.... Brook C.G.	1991	IGF1
50	Effect of chronic clonidine treatment on urinary grow th hormone excretion and linear growth in children with short stature. (2100275)	SanmartA- A.... Audi L.	1990	IGF1

Genes related to short stature according to GeneCards:

(show top 50)    (show all 205)

id	Symbol	Description	Score	GeneCards Section Context
1	SHOX	short stature homeobox	11.1	Orthologs, Publications, Transcripts, Databases (show all 8 sections) Aliases & Descriptions, Proteins, Summaries, Functions
2	SHOX2	short stature homeobox 2	11.1	Transcripts, Aliases & Descriptions, Summaries, Orthologs (show all 6 sections) Publications, Proteins
3	MRSS	Mental retardation, X-linked, with short stature	11.1	Aliases & Descriptions, Publications
4	GH1	growth hormone 1	11.1	Publications, Summaries
5	GHR	growth hormone receptor	11.1	Publications, Summaries
6	GHRHR	growth hormone releasing hormone receptor	11.1	Summaries, Publications
7	GHSR	growth hormone secretagogue receptor	11.1	Publications, Summaries
8	CTSK	cathepsin K	11.1	Summaries
9	ANKRD11	ankyrin repeat domain 11	11.1	Summaries
10	ACAN	aggrecan	11.0
11	RMRP	RNA component of mitochondrial RNA processing endoribonuclease	11.0	Publications
12	PQBP1	polyglutamine binding protein 1	11.0
13	LHX4	LIM homeobox 4	11.0	Publications
14	HESX1	HESX homeobox 1	11.0	Publications
15	MATN3	matrilin 3	11.0
16	COL10A1	collagen, type X, alpha 1	11.0
17	FGD1	FYVE, RhoGEF and PH domain containing 1	11.0
18	ARSE	arylsulfatase E (chondrodysplasia punctata 1)	11.0
19	COMP	cartilage oligomeric matrix protein	11.0
20	SRY	sex determining region Y	11.0	Publications
21	NPR2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	11.0	Publications
22	POU1F1	POU class 1 homeobox 1	11.0	Publications
23	LBX1	ladybird homeobox 1	11.0
24	TAZ	tafazzin	11.0
25	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications, Functions
26	PROP1	PROP paired-like homeobox 1	11.0
27	TBCE	tubulin folding cofactor E	11.0
28	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
29	STAT5B	signal transducer and activator of transcription 5B	11.0	Publications
30	COL1A2	collagen, type I, alpha 2	11.0	Publications
31	COL2A1	collagen, type II, alpha 1	11.0
32	GDF5	growth differentiation factor 5	11.0
33	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.0
34	FGFR3	fibroblast growth factor receptor 3	11.0	Publications
35	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
36	GHRH	growth hormone releasing hormone	11.0	Publications
37	NSD1	nuclear receptor binding SET domain protein 1	11.0	Publications
38	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
39	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
40	EVC	Ellis van Creveld syndrome	11.0
41	CFI	complement factor I	11.0
42	RAI1	retinoic acid induced 1	11.0
43	ATRX	alpha thalassemia/mental retardation syndrome X-linked	11.0	Publications
44	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.0	Publications
45	SOS1	son of sevenless homolog 1 (Drosophila)	11.0	Publications
46	STS	steroid sulfatase (microsomal), isozyme S	11.0	Publications
47	TXNRD2	thioredoxin reductase 2	11.0
48	TBX5	T-box 5	11.0	Publications
49	AGL	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	11.0
50	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications

Pathways related to short stature according to GeneDecks:

(show top 50)    (show all 244)

id	Pathway	Score	Top Affiliating Genes
1	Activation of cAMP-Dependent PKA36	INF	MAP2K2, IGF1, GNRH1, GHRH, LTBP3,
2	Renin-Angiotensin Pathway36	INF	REN, , IGF1, BMP5, RAF1, IGF2
3	eNOS Signaling36	INF	IGF1, BMP5, , LTBP3, GHRH, GH1
4	MAPK Signaling36	INF	MAP2K1, NRAS, GHRH, ROR2, GDF5, HRAS
5	Activation of PKA through GPCR36	INF	BRAF, GNRH1, IGF1R, IGF2, IGF1, HRAS
6	FAK1 Signaling36	INF	MAP2K2, NRAS, SOS1, , HRAS, MAP2K1
7	Estrogen Pathway36	INF	, HRAS, GH1, GHRH, NR0B1, NRAS
8	ERK Signaling36	INF	GH1, HRAS, GNRH1, GDF5, SOS1,
9	GPCR Pathway36	INF	GNRH1, IGF1, IGF2, IGF1R, MAP2K1, MAP2K2
10	Rap1 Pathway36	INF	BRAF, SOS1, , LTBP3, NRAS, GH1
11	Development_Prolactin receptor signaling41	11.1	EP300, PTPN11, HRAS, GH1, MAP2K1, MAP2K2
12	Development Prolactin receptor signaling10	11.1	PTPN11, STAT5B, PRLR, SOS1, EP300, GH1
13	Development_IGF-1 receptor signaling41	10.9	MAP2K1, RAF1, MAP2K2, SOS1, IGFBP1, IGF1R
14	Development IGF-RI signaling10	10.9	IGF1, RAF1, MAP2K1, IGFBP3, IGFBP1, IGF1R
15	Prolactin Signaling36	10.9	BRAF, RAF1, CREBBP, MAP2K2, EP300, MAP2K1
16	Renal cell carcinoma20	10.6	MAP2K2, HRAS, SOS1, EP300, CREBBP, NRAS
17	Transcription_Receptor-mediated HIF regulation41	10.6	IGF1R, IGFBP3, RAF1, HRAS, IGF1, MAP2K2
18	Pathway_PA16598005034	10.3	MAP2K1, KRAS, HRAS, BRAF, RAF1, FGFR3
19	Prostate cancer20	10.3	MAP2K1, SOS1, CREBBP, NRAS, HRAS, EP300
20	Acute myeloid leukemia20	10.2	ZBTB16, BRAF, RAF1, MAP2K2, HRAS, MAP2K1
21	Transcription Receptor-mediated HIF regulation10	10.2	IGFBP3, RAF1, INS, MAP2K1, IGF1R, IGF1
22	Bladder cancer20	9.4	MMP9, NRAS, RAF1, FGFR3, MAP2K2, MAP2K1
23	JAK-STAT Pathway36	INF	GHR, RAF1, BMP5, GHRH, , FGF23
24	TGF-Beta Pathway36	INF	GNRH1, IGF1, IGF2, MAP2K1, MAP2K2, HRAS
25	Integrin Pathway36	INF	MAP2K2, COL9A3, COL2A1, COL9A1, ,
26	PTEN Pathway36	INF	BMP5, BRAF, , FGF23, FGFR3, FBN1
27	Pathways in cancer20	INF	IGF1R, AR, NRAS, MMP9, ZBTB16, CREBBP
28	eIF2 Pathway36	INF	GNRH1, HRAS, GH1, GHRH, NRAS, LTBP3
29	Rac1 Pathway36	INF	MAP2K1, GDF5, BMP5, , GHRH, NRAS
30	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	INF	COL1A1, COL1A2, GNAS, PTHLH, IHH, MMP13
31	CREB Pathway36	INF	GDF5, EP300, , LTBP3, CREBBP, GHRH
32	Development Ligand-independent activation of ESR1 and ESR210	INF	CREBBP, MAP2K1, MAP2K2, , EP300, SOS1
33	ILK Signaling36	INF	FLNB, GDF5, GNRH1, IGF1, LTBP3, IGF2
34	Paxillin Interactions36	INF	GDF5, , LTBP3, ROR2, SOS1, FGF23
35	GnRH Signaling36	INF	COL2A1, SOS1, , COL9A3, COL1A2, COL9A2
36	Development_Ligand-independent activation of ESR1 and ESR241	INF	RAF1, HRAS, SOS1, CREBBP, GNAS, IGF1
37	Ras Pathway36	INF	HRAS, IGF2, BRAF, GNRH1, GHRH, NRAS
38	PPAR Pathway36	INF	GH1, FGFR3, SOS1, LTBP3, CREBBP, NRAS
39	Molecular Mechanisms of Cancer36	INF	GDF5, EP300, ROR2, SOX3, GNRH1, IGF2
40	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	INF	MMP13, IHH, GNAS, COL1A1, RUNX2, PTHLH
41	Chronic myeloid leukemia20	INF	RAF1, MAP2K2, MAP2K1, NRAS, HRAS, PTPN11
42	MAPK Family Pathway36	INF	MAP2K1, RAF1, FGF23, FGFR3, IL2RG, BRAF
43	Nanog in Mammalian ESC Pluripotency36	INF	FGF23, LTBP3, NRAS, GHRH, GH1, GNRH1
44	Pancreatic Adenocarcinoma36	INF	FGFR3, FGF23, MMP9, MMP13, RAF1, BMP5
45	Intracellular Calcium Signaling36	INF	IGF1, GNRH1, HRAS, GHRH, GH1, TRPV4
46	Breast Cancer Regulation by Stathmin136	INF	GDF5, ROR2, , RAF1, IGF1R, SOS1
47	Phospholipase-C Pathway36	INF	BMP5, , RAF1, FGF23, COL9A2, COL1A1
48	p70S6K Signaling36	INF	MAP2K1, MAP2K2, FGFR3, FGF23, INS, RAF1
49	14-3-3 Induced Intracellular Signaling36	INF	, HRAS, GDF5, ROR2, LTBP3, GHRH
50	Rho Family GTPases36	INF	GHRH, GH1, GNRH1, IGF1, IGF2, IGF1R

Compounds related to short stature according to GeneDecks:

(show top 50)    (show all 229)

id	Compound	Score	Top Affiliating Genes
1	alanine32	INF	BRAF, VDR, , RAF1, BGLAP, B3GAT3
2	arginine32	INF	REN, BRAF, VDR, , PBX1, BGLAP
3	steroid32	INF	REN, LMX1B, PBX1, LEP, ARSE, ARSB
4	serine32	INF	VLDLR, BRAF, VDR, , BMPR1B, RAD50
5	estrogen32	INF	BRAF, VDR, RAF1, PBX1, BGLAP, LEP
6	glutamate32	INF	BRAF, VDR, , LEP, MMP9, FMR1
7	dexamethasone32 42 34 9 9	INF	REN, VDR, RAF1, PBX1, BGLAP, LEP
8	glucose32	INF	BRAF, IGF2, CASR, GJA1, GHRHR, GHSR
9	c-peptide32	11.0	LEP, IGF2, IGFBP2, GHR, GHRL, CYP21A2
10	dehydroepiandrosterone sulfate32	11.0	LEP, AR, INS, IGFBP1, IGF2, IGFBP3
11	clomiphene citrate32	11.0	INS, IGFBP1, IGF1R, IGFBP3, IGF1, GNRH1
12	dhea32	11.0	LEP, AR, INS, IGFBP1, IGF2, IGFBP2
13	triiodothyronine32	11.0	LEP, IGFBP1, IGF2, IGFBP3, IGF1, GJA1
14	hexarelin32	10.9	PBX1, IGFBP3, IGF1, GH1, GHR, GHRH
15	ghrp32	10.9	PBX1, IGFBP3, IGF1, GH1, GHR, GHRH
16	androstenedione32 18	11.8	REN, PBX1, LEP, AR, INS, IGFBP1
17	acth32	10.5	REN, PBX1, LEP, INS, IGFBP1, IGF2
18	estradiol32 9 18 9	13.5	REN, PBX1, CFI, MMP13, AR, MAP2K1
19	progesterone32 42 9 18 9	14.5	BRAF, PBX1, ZBTB16, AR, FBN1, MAP2K1
20	octreotide32 42 9 9	13.4	INS, FGF23, IGFBP1, IGF1R, IGF2, IGFBP3
21	bromocriptine32 9 9	12.3	IGF2, IGFBP3, IGF1, GNRH1, GH1, GHR
22	deoxypyridinoline32	10.2	VDR, BGLAP, CD36, IGFBP1, IGFBP2, IGFBP3
23	estrone32 9 18 9	13.2	BGLAP, LEP, ARSE, ARSB, AR, IGFBP1
24	progestin32	10.1	AR, IGFBP1, IGF1R, IGF2, IGFBP2, ALPP
25	pyridinoline32	10.1	BGLAP, CD36, IGFBP2, IGFBP3, IGF1, ALPP
26	tamoxifen32 34 9 9	12.9	VDR, RAF1, BGLAP, LEP, AR, IGFBP1
27	ribonucleic acid32	9.8	MMP13, MMP9, IGFBP1, IGF1R, IGF2, IGFBP2
28	hydrocortisone32 9 9	11.8	REN, PBX1, BGLAP, CD36, INS, IGFBP1
29	25-hydroxyvitamin d32	9.7	VDR, BGLAP, LEP, FGF23, ALPP, CASR
30	creatinine32	9.3	REN, VLDLR, VDR, LEP, CFI, MMP9
31	alendronate32 9 9	11.2	VDR, BGLAP, CD36, MMP13, IGF1, ALPP
32	phosphatidylinositol32	9.1	BRAF, RAF1, LEP, MMP13, MMP9, MAP2K2
33	thyroxine32 18	10.0	REN, VDR, BGLAP, LEP, CFI, INS
34	retinoic acid32 42 18	10.8	BRAF, VDR, RAF1, RAI1, BGLAP, ZBTB16
35	1,25 dihydroxy vitamin d332	8.7	VDR, RAF1, BGLAP, FGF23, MAP2K1, IGFBP3
36	cycloheximide32	8.7	VDR, RAF1, PARK7, LEP, CD36, MMP13
37	calcitriol32 42 9 18 9	12.5	REN, VDR, BGLAP, CFI, CD36, AR
38	norepinephrine32 9 18 9	11.4	REN, LEP, MMP9, INS, MAP2K1, IGFBP1
39	pge232	8.4	REN, RAF1, MMP13, AR, MAP2K1, IGF1R
40	cysteine32	INF	VDR, RAF1, BGLAP, PARK7, PAPSS2, LHX3
41	forskolin32 42 9 9	INF	REN, BRAF, RAF1, FMR1, MAP2K1, IGFBP1
42	thymidine32 18	INF	VDR, RAF1, MMP13, MAP2K1, IGFBP1, IGF1R
43	dihydrotestosterone32 9 18 9	INF	VDR, BGLAP, LEP, AR, MAP2K1, IGFBP1
44	aspartate32	INF	BRAF, VDR, , RAF1, MMP9, GNRH1
45	vitamin d32	INF	VDR, BGLAP, CD36, AR, FGF23, FBN1
46	testosterone32 9 18 9	INF	VDR, RAF1, PBX1, BGLAP, PARK7, ZBTB16
47	vegf32	INF	REN, BRAF, RAF1, BGLAP, LEP, CD36
48	gnrh32	INF	RAF1, PBX1, LHX3, LEP, AR, INS
49	tyrosine32	INF	VLDLR, BRAF, LMX1B, BMPR1B, RAF1, PBX1
50	procollagen32	INF	, BGLAP, CD36, MMP13, MMP9, IGFBP2

Cellular components related to short stature according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	INF	RPS24, RPS7, RPL5, NF1, RNF168, SHOX
2	endoplasmic reticulum lumen	GO:005788	10.5	COL9A3, SIL1, LEPRE1, COL9A1, COL2A1, STS
3	cytosolic small ribosomal subunit	GO:022627	10.3	RPS19, RPS17, RPS24, RPS7, RPS10, RPS26
4	collagen type IX	GO:005594	10.1	COL9A1, COL9A3, COL9A2
5	Golgi apparatus	GO:005794	10.0	GNPTG, MAP2K1, MAP2K2, AP4S1, AP4B1, IMPAD1
6	proteinaceous extracellular matrix	GO:005578	9.6	COMP, DSPP, LEPRE1, MMP13, MMP9, FBN1
7	extracellular space	GO:005615	INF	GDF5, IGFBP3, IGFBP2, IGF2, IGFBP1, IHH
8	extracellular region	GO:005576	INF	CSH1, NPPB, GAL, ALB, CXADR,
9	microtubule basal body	GO:005932	INF	IFT80, EVC, EVC2, IFT122, , WDR35

Biological processes related to short stature according to GeneDecks:

(show top 50)    (show all 57)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-dependent	GO:045893	INF	TBX5, SRY, , , COL1A1, NSD1
2	small molecule metabolic process	GO:044281	INF	ARSB, ARSE, CD36, B3GAT3, B4GALT7, CHST3
3	negative regulation of cell proliferation	GO:008285	INF	TBX5, PTHLH, HRAS, GJA1, DLG3, POU1F1
4	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	VDR, LHX3, BMP5, HOXA13, THRB, IHH
5	blood coagulation	GO:007596	INF	, HRAS, GNAS, ALB, PTPN11, NRAS
6	axon guidance	GO:007411	INF	COL1A1, COL9A2, COL1A2, COL9A3, COL2A1,
7	positive regulation of multicellular organism growth	GO:040018	11.3	GHSR, GH1, GHR, GHRH, STAT5B, GHRHR
8	growth hormone secretion	GO:030252	11.1	GAL, GHSR, GHRL, GHRHR, GHRH
9	regulation of multicellular organism growth	GO:040014	11.1	IGF1, PTPN11, PRL, GHR, GDF5, STAT5B
10	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	11.1	GHR, CSH1, PRL, PRLR, STAT5B, GH1
11	organ morphogenesis	GO:009887	10.9	HRAS, COMP, COL9A1, THRB, SOX3, EP300
12	female pregnancy	GO:007565	10.9	GNAS, LEP, STAT5B, STS, PRL, CSH1
13	response to glucocorticoid stimulus	GO:051384	10.9	GHR, IGFBP2, MAP2K1, BGLAP, GHRHR, EP300
14	response to estrogen stimulus	GO:043627	10.9	STS, EP300, GHRHR, ARSB, GAL, BGLAP
15	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	10.8	GH1, IGF1, IGFBP3, GHRHR, AR, GHRH
16	cartilage development	GO:051216	10.8	IHH, ZBTB16, BMP5, EVC, GHRL, COL2A1
17	positive regulation of MAPK cascade	GO:043410	10.8	CD36, LEP, FGFR3, AR, INS, IGF2
18	insulin receptor signaling pathway	GO:008286	10.8	IGFBP1, INS, KRAS, FGF23, SOS1, NRAS
19	hormone-mediated signaling pathway	GO:009755	10.7	REN, GHRL, GHR, GHSR, PTPN11
20	viral transcription	GO:019083	10.6	RPL35A, RPS17, RPS26, RPS24, RPS7, RPL5
21	translational termination	GO:006415	10.6	RPS19, RPS10, RPL5, RPS7, RPS24, RPS17
22	activation of MAPKK activity	GO:000186	10.6	RAF1, NRAS, MAP2K2, LAMTOR2
23	viral infectious cycle	GO:019058	10.6	RPL11, RPS10, RPL5, RPS26, RPS24, RPS7
24	Ras protein signal transduction	GO:007265	10.6	MAP2K1, MAP2K2, NRAS, NF1, KRAS, SOS1
25	translational elongation	GO:006414	10.6	RPS10, RPS24, RPS17, RPL35A, RPS26, RPS7
26	MAPK cascade	GO:000165	10.6	RAF1, INS, FGFR3, MAP2K2, MAP2K1, KRAS
27	SRP-dependent cotranslational protein targeting to membrane	GO:006614	10.6	RPS17, RPS24, RPS7, RPL35A, RPL5, RPS10
28	endochondral ossification	GO:001958	10.6	COL2A1, PTHLH, COL1A1, IMPAD1, FGFR3
29	regulation of synaptic transmission, GABAergic	GO:032228	10.6	KRAS, HRAS, NRAS, NF1
30	chondroitin sulfate metabolic process	GO:030204	10.5	B3GAT3, SDC2, HYAL1, CHST3, IMPAD1, B4GALT7
31	translational initiation	GO:006413	10.5	RPS17, RPS24, RPS7, RPL35A, RPS26, RPS10
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO:000184	10.5	RPL11, RPL5, RPS7, RPS24, RPS17, RPL35A
33	prostate gland growth	GO:060736	10.5	CYP19A1, AR, IGF1, PRLR
34	ribosomal small subunit biogenesis	GO:042274	10.5	RPS17, RPS24, RPS7, RPS19
35	heart development	GO:007507	10.3	TBX5, NPPB, TAZ, RAF1, VLDLR, FBN1
36	positive regulation of cell proliferation	GO:008284	10.2	KRAS, AR, STS, INS, FGFR3, IGF1R
37	response to estradiol stimulus	GO:032355	10.2	VDR, MMP9, IHH, GH1, GHR, CYP19A1
38	leukocyte migration	GO:050900	10.2	NRAS, COL1A1, COL1A2, KRAS, CXADR, SOS1
39	glycosaminoglycan metabolic process	GO:030203	10.2	EXT2, GLB1, ACAN, GALNS, HYAL1, ARSB
40	osteoblast differentiation	GO:001649	10.1	BGLAP, RUNX2, IHH, COL1A1, TWIST1, NF1
41	carbohydrate metabolic process	GO:005975	9.9	GLB1, EXT2, EXT1, ARSB, HYAL1, ACAN
42	negative regulation of apoptotic process	GO:043066	9.9	ALB, NKX3-2, PROP1, COL2A1, GHRL, RAF1
43	signal transduction	GO:007165	INF	ROR2, FGD1, IGFBP1, MAP2K1, IL2RG, AR
44	fibroblast growth factor receptor signaling pathway	GO:008543	INF	NRAS, FGF23, PTPN11, HRAS, MAP2K2, BRAF
45	response to hypoxia	GO:001666	INF	SDC2, STAT5B, MMP9, , CREBBP, PLOD2
46	epidermal growth factor receptor signaling pathway	GO:007173	INF	, SOS1, KRAS, NRAS, PTPN11, HRAS
47	skeletal system development	GO:001501	INF	EBP, HOXA13, EVC, EXT1, IGF1, IGF2
48	extracellular matrix organization	GO:030198	INF	MMP13, , LEPRE1, MMP9, PLOD2, COL9A3
49	nerve growth factor receptor signaling pathway	GO:048011	INF	HRAS, MAP2K2, FGD1, RAF1, BRAF, PTPN11
50	ossification	GO:001503	INF	RUNX2, TWIST1, DSPP, SLC26A2, EXT2, EXT1

Molecular functions related to short stature according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	NR0B1, MPLKIP, CDT1, CDC6, MMP9, FMR1
2	extracellular matrix structural constituent	GO:005201	10.8	COL1A1, COMP, COL1A2, DSPP, MATN3, FBN1
3	extracellular matrix structural constituent conferring tensile strength	GO:030020	10.6	COL9A1, COL9A3, COL9A2, COL2A1
4	insulin receptor binding	GO:005158	10.4	IGF2, IGF1R, IGF1, INS, PTPN11
5	insulin-like growth factor receptor binding	GO:005159	10.4	REN, INS, IGF2, IGF1
6	peptide hormone receptor binding	GO:051428	9.9	PTPN11, PTHLH, LEP, NPPB
7	hormone activity	GO:005179	9.8	SST, NPPB, CSH1, INS, PRL, PTHLH
8	sequence-specific DNA binding transcription factor activity	GO:003700	INF	LMX1B, , CREBBP, SHOX, SHOX2, HESX1
9	sequence-specific DNA binding	GO:043565	INF	AR, HOXA13, NKX3-2, HOXD13, POU1F1, THRB