MCID: SLD003
MIFTS: 44

Sialadenitis malady

Categories: Rare diseases, Gastrointestinal diseases, Cardiovascular diseases, Oral diseases, Immune diseases, Endocrine diseases

Aliases & Classifications for Sialadenitis

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Aliases & Descriptions for Sialadenitis:

Name: Sialadenitis 10 45 47 12 36 65
Sialoadenitis 10 45
 
Salivary Gland Inflammation 45
Adenitis, Salivary Gland 45

Classifications:



External Ids:

Disease Ontology10 DOID:10303
ICD1027 K11.2, K11.20
ICD9CM29 527.2
MeSH36 D012793
NCIt42 C26882
UMLS65 C0037023

Summaries for Sialadenitis

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NIH Rare Diseases:45 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/17/2014

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to xanthogranulomatous sialadenitis and igg4-related dacryoadenitis and sialadenitis, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (Tumor Necrosis Factor Superfamily Member 13b), and among its related pathways are Cytokines and Inflammatory Response and Rheumatoid arthritis. Affiliated tissues include salivary gland, thyroid and prostate, and related mouse phenotypes are integument and digestive/alimentary.

Wikipedia:68 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1xanthogranulomatous sialadenitis12.1
2igg4-related dacryoadenitis and sialadenitis12.1
3igg4-related submandibular gland disease10.9
4hypercalcemic sarcoidosis10.7TNC, TNF
5autoimmune polyglandular syndrome type 210.7HLA-DQB1, TNF
6best1 retinopathy10.7HLA-DQB1, TNF
7non-distal monosomy 10q10.6HLA-DQB1, TNF
8syndactyly10.6HSPG2, TNC
9lymphocytic choriomeningitis10.6HLA-DQB1, TNF
10moderately severe hemophilia a10.6HLA-DQB1, TNF
11cytoplasmic body myopathy10.6HLA-DQB1, TNF
12argentine hemorrhagic fever10.6HSPG2, TNF
13duodenum cancer10.5HLA-DQB1, TNF
14chronic hiccups10.5CD4, TNFSF13B
15megacolon10.5HTR3A, TNC
16ethmoid sinus squamous cell carcinoma10.5CD4, TNF
17achalasia10.5CD4, TNF
18hepatoid adenocarcinoma10.5HLA-DQB1, TNF
19fusariosis10.5CD4, TNF
20zebra body myopathy10.5HTR3A, TNF
21desquamative interstitial pneumonia10.5CD4, TNC
22prostate transitional cell carcinoma10.5CD4, TNF
23kernicterus due to isoimmunization10.5HLA-DQB1, TNF
24neuritis10.5CDSN, HSPG2
25streptococcal meningitis10.5CD4, TNF
26b cell deficiency10.5CD4, TNF
27conjunctival degeneration10.5CDSN, HSPG2
28aniseikonia10.5CD4, TNF
29mycotic corneal ulcer10.5CD4, HSPG2
30chromosome 9p deletion syndrome10.5CD4, TNF
31soft palate cancer10.4CD4, TNF
32chronic tic disorder10.4CD4, TNF
33idiopathic juxtafoveal retinal telangiectasia10.4HLA-DQB1, TRIM21
34cerebellar angioblastoma10.4TNC, TNF, TNFSF13B
35opportunistic bacterial infectious disease10.4CD4, TNF
36myositis ossificans10.4CD4, CDSN
37cerebral sarcoidosis10.4AQP5, TNF
38meige syndrome10.4CD4, TNF
39congenital nasal pyriform aperture stenosis with holoprosencephaly10.4TNF, TRIM21
40cryoglobulinemia10.4CD4, TNF
41cervical incompetence10.3CD4, CDSN
42constant exophthalmos10.3CD4, TNF
43bacterial exanthem10.2CD4, HSPG2
44byssinosis10.2CD4, HLA-DQB1, TNF
45kunjin encephalitis10.2TNF, TRIM21
46artery disease10.2HLA-DQB1, TNF
47lymphoma10.2
48artemis deficiency10.2CD4, HLA-DQB1
49signet ring cell adenocarcinoma10.2HSPG2, TNF
50trichostrongyloidiasis10.2CD4, TNF

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Hypertension, EssentialDeficiency Anemia
Heart DiseaseMucocele of Salivary Gland
SialolithiasisAcute Cystitis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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UMLS symptoms related to Sialadenitis:


salivary gland pain

Drugs & Therapeutics for Sialadenitis

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Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 1, Phase 21582174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Immunologic FactorsPhase 1, Phase 218483
3Antirheumatic AgentsPhase 1, Phase 28496

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dental Safety Profile of High-Dose Radioiodine TherapyCompletedNCT00439478Phase 4
2Rituximab in IgG4-related Disease: A Phase 1-2 TrialCompletedNCT01584388Phase 1, Phase 2
3The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid CancerRecruitingNCT01833650
4Cohort Study of IgG4RDRecruitingNCT01670695Phase 0

Search NIH Clinical Center for Sialadenitis


Cochrane evidence based reviews: sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

33
Salivary gland, Thyroid, Prostate, T cells, Lung, Breast, B cells

Animal Models for Sialadenitis or affiliated genes

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MGI Mouse Phenotypes related to Sialadenitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0CD4, HSPG2, HTR3A, RAG1, TNF, TRIM21
2MP:00053817.7AQP5, CD4, HLA-DQB1, HSPG2, RAG1, TNF
3MP:00053977.1CD4, HLA-DQB1, HSPG2, HTR3A, RAG1, TNF
4MP:00053876.8CD4, HLA-DQB1, HSPG2, HTR3A, RAG1, TNF
5MP:00053766.4AQP5, CD4, HLA-DQB1, HSPG2, HTR3A, RAG1

Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50)    (show all 439)
idTitleAuthorsYear
1
Subacute Necrotizing Sialadenitis: A Series of Three Cases and Literature Review. (27008639)
2016
2
Clinicopathological characteristics of immunoglobulin G4-related sialadenitis. (26194097)
2015
3
Chronic Sclerosing Sialadenitis of the Submandibular Gland as the Initial Symptom of IgG4-Related Disease: A Case Report. (26084640)
2015
4
Sialendoscopy in sialadenitis: an unselected cohort of 228 patients. (26333199)
2015
5
Chronic sialadenitis with marked lymphadenopathy mimicking lymphoma on FDG PET/CT. (24978334)
2014
6
Clinical and quality-of-life outcomes following gland-preserving surgery for chronic sialadenitis. (25424183)
2014
7
Imaging in acute obstructive sialadenitis. (24712336)
2014
8
Salivary endoscopy for idiopathic chronic sialadenitis. (23712592)
2013
9
Prediction of risk for symptomatic sialadenitis by post-therapeutic dual (131)I scintigraphy in patients with differentiated thyroid cancer. (23921836)
2013
10
Autoimmune pancreatitis that developed over a 3-month observation period for IgG4-related dacryoadenitis and sialadenitis. (26182321)
2012
11
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
12
Tenascin-C in chronic sclerosing sialadenitis. (21559807)
2011
13
Sialoendoscopy in the diagnosis and management of obstructive sialadenitis. (21298637)
2011
14
Chronic Sclerosing Sialadenitis (KA1ttner's tumour) of the Parotid Gland. (22135562)
2010
15
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
16
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
17
Pathology quiz case 2. Chronic sclerosing sialadenitis (CSS). (19289717)
2009
18
Concurrent sialocoele and necrotising sialadenitis in a dog. (19261087)
2009
19
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
20
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
21
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
22
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. (17900348)
2007
23
Sialadenitis of the left submandibular gland/sialolith. (16163878)
2005
24
Chronic sclerosing sialadenitis of the parotid gland: diagnosis using color Doppler sonography and sonographically guided needle biopsy. (15784774)
2005
25
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
26
Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice. (15763917)
2004
27
Acute ischemic sialadenitis following facial artery embolization. (15129338)
2004
28
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
29
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
30
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
31
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
32
Subacute necrotizing sialadenitis in the buccal mucosa. (12465016)
2002
33
Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS). (11693172)
2001
34
Relation of preoperative sialographic findings with histopathological diagnosis in cases of obstructive sialadenitis of the parotid and submandibular glands: retrospective study. (10475651)
1999
35
Lymphoma presenting as parotid xanthogranulomatous sialadenitis. (9881792)
1998
36
Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. (9409649)
1997
37
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
38
On focal lymphocytic sialadenitis as a gold standard for the diagnosis of SjAPgren's syndrome: comment on the article by Daniels and Whitcher. (7779134)
1995
39
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
40
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
41
Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction. (2036674)
1991
42
Radionuclide imaging of potassium iodide-induced sialadenitis. (3034466)
1987
43
Sialadenitis in children. (3744701)
1986
44
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
45
Contrast induced sialadenitis--a case report. (6544850)
1984
46
Diagnosis please. Benign follicular hyperplasia of a submandibular lymph node and chronic sialadenitis. (4516846)
1973
47
SODIUM IODIDE-INDUCED SUBMAXILLARY SIALADENITIS IN THE RAT. (14101183)
1963
48
Chronic sialadenitis and sialography. (14370773)
1955
49
50

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7CD4, TNF
29.6HLA-DQB1, TNF, TNFSF13B
39.2CD4, RAG1

GO Terms for genes affiliated with Sialadenitis

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Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00069558.6CD4, RAG1, TNF, TNFSF13B

Sources for Sialadenitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet