MCID: SLD003
MIFTS: 53

Sialadenitis malady

Gastrointestinal diseases, Endocrine diseases categories

Summaries for Sialadenitis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/4/2010

MalaCards: Sialadenitis, also known as sialoadenitis, is related to hepatitis and hepatitis c. An important gene associated with Sialadenitis is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Immune response NFAT in immune response and Immune response ICOS pathway in T-helper cell. The compounds cycloheximide and thymoglobulin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, b cells and t cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Wikipedia:63 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Aliases & Classifications for Sialadenitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

sialadenitis 8 42 10 44 60
sialoadenitis 8 42
salivary gland inflammation 42
adenitis, salivary gland 42
sialoadenitis nos 8


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Disease Ontology8 DOID:10303
MeSH34 D012793
NCIt39 C26882
ICD9CM27 527.2
ICD1025 K11.2

Related Diseases for Sialadenitis

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17GeneCards, 18GeneDecks
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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.4HSPG2
2hepatitis c30.4TIMP3, CALR, TNFSF13B, CD28, PTPRC
3arthritis30.3TIMP3, OSM, CD80
4pancreatitis30.2HSPG2
5hepatitis b30.2HLA-DQB1, ITGAL, CD80
6autoimmune hepatitis30.1HSPG2, HLA-DQB1, PTPRC
7glomerulonephritis30.1CD28, ITGAL
8hodgkin's lymphoma30.1TNFSF13B, EBI3, CD80, CD28, PTPRC
9rheumatoid arthritis30.1TNFSF13B, CALR, TIMP3, HSPG2, OSM, HLA-DQB1
10thyroid cancer30.0TNC, TIMP3, HSPG2
11sjogren's syndrome29.9HSPG2, CALR, TNFSF13B, ITGAL, SSB, TROVE2
12purpura29.9HSPG2
13connective tissue disease29.8TROVE2
14lupus erythematosus29.7CALR, TROVE2
15vasculitis29.7TNFSF13B, CD80
16osteoarthritis29.7CD80, OSM, TIMP3
17primary biliary cirrhosis29.7HSPG2, CALR, ITGAL
18sarcoidosis29.7HLA-DQB1, CD80, CD28, PTPRC
19leukemia29.7HTR3A, OSM, ITGAL, CD80, PTPRC
20tuberculosis29.7CALR, HLA-DQB1, ITGAL, PTPRC
21sialolithiasis10.3
22xanthogranulomatous sialadenitis10.2
23dacryoadenitis10.2
24thyroiditis10.2
25mumps10.2
26myelitis10.1
27keratoconjunctivitis sicca10.1
28keratoconjunctivitis10.1
29cholangitis10.1
30obesity10.1
31salivary gland disease10.1
32mikulicz disease10.1
33anhidrosis10.0
34chronic dacryoadenitis10.0
35acquired immunodeficiency syndrome10.0
36sclerosing cholangitis10.0
37hepatitis a10.0
38hypertension10.0
39systemic lupus erythematosus10.0TNFSF13B
40dry eye syndrome10.0HSPG2
41diabetic retinopathy10.0TIMP3
42proliferative diabetic retinopathy10.0TIMP3
43malt lymphoma10.0CD80
44dementia10.0HTR3A
45wegener's granulomatosis10.0CD80, CD28
46stomach cancer10.0CD80, TIMP3
47polymyositis10.0CD28, CD80, HSPG2
48dermatomyositis10.0CD28, TROVE2, HSPG2
49osteosarcoma10.0HSPG2, OSM
50severe combined immunodeficiency10.0PTPRC

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Clinical Features for Sialadenitis

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Drugs & Therapeutics for Sialadenitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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32MalaCards
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MalaCards organs/tissues related to Sialadenitis:

32
Salivary gland, B cells, T cells, Thyroid, Lymph node, Liver, Lung, Thymus, Endothelial, Tongue

Animal Models for Sialadenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sialadenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1HTR3A, HLA-DQB1, TROVE2, EBI3, PTPRC, TIMP3
2MP:00053978.2HTR3A, TNFSF13B, TIMP3, HSPG2, HLA-DQB1, ITGAL
3MP:00053878.1PTPRC, HSPG2, TIMP3, TNFSF13B, HTR3A, HLA-DQB1
4MP:00053847.9TNFSF13B, CALR, TIMP3, HSPG2, HLA-DQB1, ITGAL
5MP:00036317.9HSPG2, CALR, TNC, HTR3A, OSM, HLA-DQB1
6MP:00053767.9TNC, CALR, TIMP3, HSPG2, HTR3A, HLA-DQB1

Publications for Sialadenitis

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50PubMed
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Articles related to Sialadenitis:

(show top 50)    (show all 373)
idTitleAuthorsYear
1
Ultrasound in sialadenitis. (24046793)
2013
2
IgG4-related sialadenitis is rare: histopathological investigation of 129 cases of chronic submandibular sialadenitis. (23692045)
2013
3
Symptomatic late-onset sialadenitis after radioiodine therapy in thyroid cancer. (23389626)
2013
4
Pediatric chronic sclerosing sialadenitis: KA1ttner tumor. (21985393)
2012
5
TACI-Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non-obese diabetic mice. (22212434)
2012
6
Acute submandibular sialadenitis-a case report. (22888457)
2012
7
Radiology quiz case 1. Iodine 131a89induced sialadenitis. (22710514)
2012
8
Brief report: first identification of Ha88 histamine receptor in healthy salivary glands and in focal sialadenitis in SjAPgren's syndrome. (22488408)
2012
9
Epithelial Na+ channel (ENaC) expression in obstructive sialadenitis of the submandibular gland. (20926064)
2011
10
Concurrent sialocoele and necrotising sialadenitis in a dog. (19261087)
2009
11
Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in SjAPgren's syndrome-associated autoimmune sialadenitis. (19716548)
2009
12
A case of immunoglobulin G4-related chronic sclerosing sialadenitis and dacryoadenitis associated with tuberculosis. (18855098)
2009
13
Classification and management of chronic sialadenitis of the parotid gland. (18976271)
2009
14
An unusual giant subacute necrotizing sialadenitis as an emergency case of otolaryngology. (19860638)
2009
15
A case of hyperIgG4 disease or IgG4-related sclerosing disease presenting as retroperitoneal fibrosis, chronic sclerosing sialadenitis and mediastinal lymphadenopathy. (19291547)
2009
16
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
17
Postoperative acute sialadenitis after skull base surgery. (18769650)
2008
18
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
19
Surgical treatment of chronic parotid sialadenitis. (17166325)
2007
20
Xanthogranulomatous sialadenitis: a case report and literature review. (16075862)
2005
21
Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis. (16297151)
2005
22
Multiple granulomatous inflammation in the minor salivary glands: a proposed new entity, allergic granulomatous sialadenitis. (15533228)
2004
23
Regeneration in chronic sialadenitis: an analysis of proliferation and apoptosis based on double immunohistochemical labelling. (14762713)
2004
24
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
25
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
26
Involvement of Fas/Fas ligand in the induction of apoptosis in chronic sialadenitis of minor salivary glands including SjAPgren's syndrome. (12126064)
2002
27
Aerobic and anaerobic microbiology of suppurative sialadenitis. (12018662)
2002
28
Prophylaxis of radiogenic sialadenitis and mucositis by coumarin/troxerutine in patients with head and neck cancer--a prospective,randomized, placebo-controlled, double-blind study. (11178853)
2001
29
Neonatal submandibular sialadenitis progressing to submandibular gland abscess. (10862929)
2000
30
Lower frequency of focal lip sialadenitis (focus score) in smoking patients. Can tobacco diminish the salivary gland involvement as judged by histological examination and anti-SSA/Ro and anti-SSB/La antibodies in SjAPgren's syndrome? (10627428)
2000
31
Fine needle aspiration cytodiagnosis of sialadenitis with crystalloids. (10349367)
1999
32
Scintigraphic features of chronic sialadenitis and SjAPgren's syndrome: a comparison. (10664993)
1999
33
Discordance of sialography and scintigraphy in unilateral chronic sialadenitis. (9770717)
1998
34
Complicated neonatal submandibular suppurative sialadenitis. (9780073)
1998
35
Tumor-associated glycoprotein (TAG-72) in chronic submandibular sialadenitis and normal minor salivary glands defined by monoclonal antibody B72.3. (9261022)
1997
36
Sulfadiazine-induced sialadenitis. (8997468)
1997
37
Acquired generalized hypohidrosis/anhidrosis with subclinical SjAPgren's syndrome: report of a case with diffuse syringolymphoid hyperplasia and lymphocytic sialadenitis. (8698925)
1996
38
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
39
Subacute necrotising sialadenitis: a new entity? (8555147)
1995
40
Scintigraphic evaluation of sialadenitis. (8173870)
1994
41
Sialadenitis associated with periorbital disease in a dog. (8360092)
1993
42
Phenotyping of immunocompetent cells in normal labial and palatal salivary glands and in non-autoimmune sialadenitis. (1895251)
1991
43
Acute bacterial sialadenitis: a study of 29 cases and review. (2385766)
1990
44
Management of chronic sclerosing sialadenitis incident to second-stage implant surgery. (3267469)
1988
45
Chronic non specific sialadenitis of the submandibular salivary gland. (6598625)
1984
46
Chronic sialadenitis of the submandibular gland (so-called KA1ttner tumor). (6670958)
1983
47
Morphometric and fine structural study of experimental autoallergic sialadenitis of rat submandibular glands. (100961)
1978
48
Phenylbutazone-induced sialadenitis. (4528673)
1974
49
Microbial diseases of the salivary glands with special reference to mumps and acute and chronic sialadenitis. (5264532)
1970
50
The relationship of chronic recurrent sialadenitis to the alarm reaction. (15397209)
1949

Genetic Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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12EMD Millipore, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG
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Pathways related to Sialadenitis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response NFAT in immune response
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9.7CD28, CD80, HLA-DQB1
2
Immune response ICOS pathway in T-helper cell
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9.7CD28, CD80, HLA-DQB1
3
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9.7HLA-DQB1, CD80, CD28
4
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9.7CD80, CD28, PTPRC
5
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9.6CD28, CD80, EBI3
69.5TNFSF13B, ITGAL, CD80, CD28
7
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9.5HSPG2, TIMP3, TNC, ITGAL, PLA2G3
89.3AMY1C, AMY1B, AMY1A
9
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9.3HLA-DQB1, CD80, CD28, PLA2G3, PTPRC
10
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9.3TIMP3, CCL23, TNFSF13B, ITGAL, CD80
11
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9.3CD28, CD80, ITGAL, HLA-DQB1, TIMP3
129.2HLA-DQB1, ITGAL, CD80, CD28, PTPRC
13
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9.0CD28, CALR, TNFSF13B, HLA-DQB1, ITGAL, CD80
14
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9.0CD28, CD80, TROVE2, SSB, HLA-DQB1
15
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8.5TIMP3, CCL23, TNFSF13B, OSM, ITGAL, CD80
16
Hide members
8.4TIMP3, CCL23, TNFSF13B, OSM, CD80, CD28
17
Hide members
8.2HSPG2, TIMP3, CCL23, TNC, TNFSF13B, OSM

Compounds for genes affiliated with Sialadenitis

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Sialadenitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6HSPG2
2thymoglobulin4410.2PTPRC, CD28
3ctla4-ig4410.1CD28, CD80
4propranolol44 28 49 11 2414.0HSPG2, HTR3A, ITGAL
5serine449.9OSM
6heparin44 28 11 2412.7HSPG2, TIMP3, CALR, ITGAL, PTPRC
7glycosaminoglycan449.6OSM, TNC, TIMP3
8herbimycin a44 5910.6HSPG2, OSM, CD28, PTPRC
9phosphoinositide449.6HSPG2, CALR, TNC, ITGAL, CD28
10hyaluronic acid44 2410.6PTPRC, ITGAL, OSM, TNC
11ionomycin449.5CALR, ITGAL, CD80, CD28, PTPRC
12histamine44 28 2411.5HSPG2, CALR, HTR3A, OSM, PTPRC
13wortmannin449.4HSPG2, TIMP3, TNC, ITGAL, CD80, CD28
14h2o2449.4HSPG2, CALR, TNC, ITGAL, PTPRC
15genistein44 28 59 2 11 2414.4HSPG2, TIMP3, OSM, CD28, PTPRC
16oligonucleotide449.3CD28, HLA-DQB1, TNC, CALR, TIMP3
17ly294002449.3HSPG2, TIMP3, TNC, CD28
18retinoic acid44 2410.1HSPG2, TIMP3, CALR, TNC, OSM, ITGAL
19dexamethasone44 49 28 1112.0PTPRC, TIMP3, CALR, HTR3A, OSM, ITGAL
20cysteine448.9TIMP3, CALR, TNC, OSM, ITGAL, CD28
21lipid448.8TIMP3, CALR, TNC, OSM, ITGAL, CD28
22phosphatidylinositol448.8HSPG2, TIMP3, TNC, OSM, ITGAL, CD80
23tyrosine448.3HSPG2, TIMP3, CALR, TNC, OSM, HLA-DQB1
24calcium44 49 11 2410.5HSPG2, TIMP3, CCL23, AMY1A, CALR, TNC

GO Terms for genes affiliated with Sialadenitis

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16Gene Ontology
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Cellular components related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CALR, ITGAL, CD80, CD28, PTPRC
2extracellular spaceGO:0056158.3PLA2G3, HSPG2, CCL23, CALR, TNC, TNFSF13B
3plasma membraneGO:0058868.1TNFSF13B, HTR3A, HLA-DQB1, ITGAL, EBI3, CD80

Biological processes related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-2 biosynthetic processGO:0450869.6CD28, CD80
2positive regulation of alpha-beta T cell proliferationGO:0466419.6CD28, CD80, EBI3
3positive regulation of T cell proliferationGO:0421029.6PTPRC, CD28, ITGAL, TNFSF13B
4T cell costimulationGO:0312959.4TNFSF13B, HLA-DQB1, CD80, CD28
5immune responseGO:0069559.3HLA-DQB1, OSM, TNFSF13B, CCL23

Products for genes affiliated with Sialadenitis

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Sources for Sialadenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet