MCID: SLD003
MIFTS: 50

Sialadenitis malady

Rare diseases, Gastrointestinal diseases, Endocrine diseases categories

Summaries for Sialadenitis

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NIH Rare Diseases:41 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/17/2014

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to b-cell lymphomas and arthritis. An important gene associated with Sialadenitis is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Cytokines and Inflammatory Response and IL12 signaling mediated by STAT4. The compounds cicaprost and abatacept have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and b cells, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:63 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Aliases & Classifications for Sialadenitis

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Sialadenitis, Aliases & Descriptions:

Name: Sialadenitis 9 41 11 43 60
Sialoadenitis 9 41
 
Salivary Gland Inflammation 41
Adenitis, Salivary Gland 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Endocrine diseases


External Ids:

Disease Ontology9 DOID:10303
MeSH33 D012793
NCIt38 C26882
ICD9CM27 527.2
ICD1025 K11.2

Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas30.8TNFSF13B, CD80, ITGAL
2arthritis30.7TNF, OSM
3hepatitis c30.6CD28, CD4, TIMP3, HSPG2
4thyroid cancer30.4TNC, HSPG2, TIMP3
5sjogren's syndrome30.2CD80, CD28, TNFSF13B, HSPG2, ITGAL
6vasculitis30.1TNFSF13B, CD80, TNF
7connective tissue disease30.1CD4, TNF
8t-cell leukemia30.0CD28, CD4, ITGAL
9adenoma29.9TNC, HSPG2, OSM, TIMP3
10tuberculosis29.6ITGAL, TNF, CD4, HLA-DQB1
11osteoarthritis29.4TNF, OSM, MMP2, CD80, TIMP3
12leukemia29.3OSM, CD80, CD4, ITGAL, HTR3A, TNF
13rheumatoid arthritis28.3TNFSF13B, TIMP3, MMP2, ITGAL, CD4, CD28
14xanthogranulomatous sialadenitis10.5
15nodular goiter10.4CD28, CD80
16extrinsic allergic alveolitis10.4CD28, ITGAL
17mast cell neoplasm10.4CD80, ITGAL
18mycobacterium avium complex disease10.4CD4
19listeriosis10.4CD4
20central nervous system lymphoma10.4CD4
21sialolithiasis10.4
22cryptococcosis10.4CD4
23histoplasmosis10.4CD4
24polymyositis10.3CD28, CD80, HSPG2
25hepatitis10.3
26dacryoadenitis10.3
27common variable immunodeficiency10.3CD28, TNFSF13B
28spondylarthropathy10.3ITGAL, TNF
29myocarditis10.3CD4
30mikulicz disease10.3
31chronic lymphocytic leukemia10.3TNFSF13B, CD80, ITGAL
32arthropathy10.3TNF, OSM
33mumps10.3
34pancreatitis10.3
35thyroiditis10.3
36retroperitoneal fibrosis10.3
37leishmaniasis10.3CD4
38leprosy10.2CD4
39graft-versus-host disease, protection against10.2CD28, ITGAL, TNF
40pulmonary sarcoidosis10.2TNF, ITGAL, CD80
41hepatitis c virus10.2
42lymphoma, non-hodgkin10.2CD80, CD28, TNFSF13B, ITGAL
43hodgkin lymphoma10.2TNFSF13B, CD80, EBI3, CD28
44myelitis10.2
45keratoconjunctivitis sicca10.2
46keratoconjunctivitis10.2
47bullous pemphigoid10.2ITGAL, TNFSF13B, HLA-DQB1
48tetanus10.2CD4, CD28, CD80
49chagas disease10.2CD28, CD4
50obesity10.2

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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Drugs & Therapeutics for Sialadenitis

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Drug clinical trials:

Search ClinicalTrials for Sialadenitis

Search NIH Clinical Center for Sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

31
Salivary gland, T cells, B cells, Thyroid, Lymph node, Liver, Thymus, Lung, Endothelial, Tongue

Animal Models for Sialadenitis or affiliated genes

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Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50)    (show all 404)
idTitleAuthorsYear
1
Chronic sialadenitis with marked lymphadenopathy mimicking lymphoma on FDG PET/CT. (24978334)
2014
2
Clinical and quality-of-life outcomes following gland-preserving surgery for chronic sialadenitis. (25424183)
2014
3
Imaging in acute obstructive sialadenitis. (24712336)
2014
4
The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease. (24593171)
2014
5
Interventional sialoendoscopy for treatment of obstructive sialadenitis. (25438275)
2014
6
Salivary endoscopy for idiopathic chronic sialadenitis. (23712592)
2013
7
Prediction of risk for symptomatic sialadenitis by post-therapeutic dual (131)I scintigraphy in patients with differentiated thyroid cancer. (23921836)
2013
8
Superficial parotidectomy for chronic parotid sialadenitis. (22560869)
2013
9
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
10
Pediatric chronic sclerosing sialadenitis: KA1ttner tumor. (21985393)
2012
11
Tenascin-C in chronic sclerosing sialadenitis. (21559807)
2011
12
Sialoendoscopy in the diagnosis and management of obstructive sialadenitis. (21298637)
2011
13
Chronic Sclerosing Sialadenitis (KA1ttner's tumour) of the Parotid Gland. (22135562)
2010
14
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
15
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
16
Pathology quiz case 2. Chronic sclerosing sialadenitis (CSS). (19289717)
2009
17
Concurrent sialocoele and necrotising sialadenitis in a dog. (19261087)
2009
18
Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in SjAPgren's syndrome-associated autoimmune sialadenitis. (19716548)
2009
19
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
20
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
21
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
22
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. (17900348)
2007
23
Surgical treatment of chronic parotid sialadenitis. (17166325)
2007
24
Sialadenitis of the left submandibular gland/sialolith. (16163878)
2005
25
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
26
Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice. (15763917)
2004
27
Acute ischemic sialadenitis following facial artery embolization. (15129338)
2004
28
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
29
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
30
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
31
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
32
Subacute necrotizing sialadenitis in the buccal mucosa. (12465016)
2002
33
Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS). (11693172)
2001
34
Relation of preoperative sialographic findings with histopathological diagnosis in cases of obstructive sialadenitis of the parotid and submandibular glands: retrospective study. (10475651)
1999
35
Lymphoma presenting as parotid xanthogranulomatous sialadenitis. (9881792)
1998
36
Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. (9409649)
1997
37
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
38
On focal lymphocytic sialadenitis as a gold standard for the diagnosis of SjAPgren's syndrome: comment on the article by Daniels and Whitcher. (7779134)
1995
39
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
40
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
41
Lymphocytic sialadenitis of SjAPgren's syndrome associated with chronic hepatitis C virus liver disease. (1346409)
1992
42
Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction. (2036674)
1991
43
Radionuclide imaging of potassium iodide-induced sialadenitis. (3034466)
1987
44
Bilateral obstructive sialadenitis of the submandibular glands due to a denture. (3474000)
1987
45
Sialadenitis in children. (3744701)
1986
46
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
47
Contrast induced sialadenitis--a case report. (6544850)
1984
48
Diagnosis please. Benign follicular hyperplasia of a submandibular lymph node and chronic sialadenitis. (4516846)
1973
49
SODIUM IODIDE-INDUCED SUBMAXILLARY SIALADENITIS IN THE RAT. (14101183)
1963
50
Chronic sialadenitis and sialography. (14370773)
1955

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TNF, CD4
29.7CD28, CD4
3
Show member pathways
9.7CD4, CD28
49.6CD28, CD80
59.6CD28, CD80
6
Show member pathways
9.6CD80, CD28
7
Show member pathways
9.6TNFSF13B, TNF, TIMP3
89.6MMP2, TIMP3, TNC
9
Show member pathways
Metalloproteases in connective tissue degradation
9.6TNC, TIMP3, MMP2
10
Show member pathways
9.5TNF, TNFSF13B, HLA-DQB1
11
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.4CD28, HLA-DQB1, CD4
129.4TNC, ITGAL, HSPG2
13
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.4TNF, CD4, MMP2
14
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.4CD80, HSPG2, TNF
15
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.4CD28, TNF, CD4
16
Show member pathways
9.3CD28, CD4, CD80
17
Show member pathways
TCR signaling in naive CD8+ T cells36
9.3CD4, CD80, CD28
18
Show member pathways
9.3HSPG2, TIMP3, MMP2, TNF
199.3HSPG2, TIMP3, TNF, MMP2
20
Show member pathways
9.3EBI3, TNF
21
Show member pathways
9.2HSPG2, TNC, TIMP3, ITGAL
22
Show member pathways
9.1MMP2, TNC, ITGAL, HSPG2
23
Show member pathways
9.0ITGAL, MMP2, TIMP3, TNF
24
Show member pathways
9.0CD80, CD28, CD4, HLA-DQB1
25
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
9.0CD28, CD80, CD4, HLA-DQB1
26
Show member pathways
9.0CD4, CD28, HLA-DQB1, CD80
27
Show member pathways
9.0CD28, CD80, CD4, HLA-DQB1
28
Show member pathways
8.7HLA-DQB1, CD28, TNF, HSPG2, CD80
29
Show member pathways
8.5HSPG2, MMP2, ITGAL, TNC, CCL23
30
Show member pathways
8.5CD4, HLA-DQB1, CD80, ITGAL, CD28
318.5CD80, CD28, CD4, ITGAL, HLA-DQB1
328.2CD80, CD28, ITGAL, HLA-DQB1, TNF, TNFSF13B
33
Show member pathways
IL27-mediated signaling events36
8.1CD4, EBI3, CD80, CD28, TNF
34
Show member pathways
7.9HLA-DQB1, TIMP3, MMP2, ITGAL, CD4, CD28
35
Show member pathways
7.8TNFSF13B, TNF, CD4, CD28, CD80, ITGAL
36
Show member pathways
7.7TNF, CD80, CD4, ITGAL, CCL23, TIMP3
37
Show member pathways
7.5OSM, TNFSF13B, TNF, CD80, CD4, CCL23
38
Show member pathways
7.3CD4, TIMP3, TNFSF13B, TNF, CD28, CD80
39
Show member pathways
6.8CD80, CD4, ITGAL, TIMP3, OSM, TNF
40
Show member pathways
6.2CD80, TNC, TNF, HSPG2, OSM, TIMP3

Compounds for genes affiliated with Sialadenitis

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Compounds related to Sialadenitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1cicaprost43 2811.0TNF, HSPG2
2abatacept43 1211.0CD80, TNF
3cilomilast4310.0MMP2, TNF
4bcma439.9TNFSF13B, TNF
5go 697643 5910.9HSPG2, MMP2, TNF
6ctla4-ig439.9CD80, CD28
7heparan sulfate43 2410.8HSPG2, TNC, TIMP3, CD4
8blys439.7TNFSF13B, TNF
9rituximab43 49 1211.7TNF, TNFSF13B, CD80
10n-formylmethionyl-leucylphenylalanine439.7TNF, HSPG2, ITGAL
11nickel43 2410.7HLA-DQB1, CD4, ITGAL
12glycosaminoglycan439.6TIMP3, OSM, TNC
13efalizumab43 1210.6ITGAL, TNF
14propranolol43 28 49 24 1213.5HTR3A, HSPG2, MMP2, ITGAL
15chloroquine43 2 49 28 1213.5ITGAL, TNF, CD4
16matrigel439.4TIMP3, TNC, OSM, MMP2
17phorbol439.4CD4, ITGAL, MMP2, TNC
18histamine43 28 2411.4OSM, TNF, HSPG2, HTR3A
19azathioprine43 2 49 1212.3ITGAL, OSM, MMP2
20phosphoinositide439.3TNC, CD28, ITGAL, HSPG2
21prednisolone43 28 1211.2MMP2, ITGAL, TNF
22heparin43 28 24 1212.2TIMP3, HSPG2, CD4, TNC, ITGAL
23oligonucleotide439.2TIMP3, CD28, CD4, TNC, HLA-DQB1
24hyaluronic acid43 2410.2ITGAL, MMP2, TNC, OSM
25pd 98,059439.2HSPG2, TNF, OSM, TIMP3, MMP2
26tgf beta1439.1OSM, TNF, MMP2, TNC, TIMP3
27ionomycin439.1TNF, CD28, ITGAL, CD80
28fibrinogen439.1OSM, ITGAL, TNF, TNC
29h2o2439.1MMP2, TNC, HSPG2, TNF, ITGAL
30ly294002439.0MMP2, CD28, TNF, TIMP3, TNC, HSPG2
31vegf438.9MMP2, TNF, HSPG2, OSM, TIMP3, TNC
32cyclosporin a43 28 5910.8ITGAL, CD28, CD80, TNF
33proline438.8CD28, CD4, MMP2, ITGAL, CD80
34herbimycin a43 599.7CD28, TNF, HSPG2, CD4, OSM, MMP2
35alanine438.7HSPG2, OSM, MMP2, CD4, ITGAL, TNFSF13B
36glutamate438.7MMP2, CD4, ITGAL, TIMP3, HSPG2, TNC
37rantes438.5ITGAL, CCL23, OSM, TNF, CD4
38genistein43 28 59 2 24 1213.5CD4, MMP2, TIMP3, OSM, HSPG2, TNF
39wortmannin438.4ITGAL, CD28, HSPG2, MMP2, TIMP3, TNC
40retinoic acid43 249.4OSM, TIMP3, MMP2, ITGAL, HSPG2, TNF
41cysteine438.2TNC, OSM, TIMP3, ITGAL, MMP2, CD4
42lipid438.2TNC, CD28, TIMP3, OSM, TNF, CD4
43oxygen43 249.2TNF, CD80, CD28, ITGAL, TIMP3
44pge2438.1OSM, CD80, CD4, ITGAL, TNF, HSPG2
45serine437.9OSM, HSPG2, CD4, TNF, TNC, MMP2
46cycloheximide437.9TNC, TNF, OSM, MMP2, ITGAL, HSPG2
47dexamethasone43 49 28 1210.6CD28, TIMP3, CD80, TNC, TNF, HSPG2
48phosphatidylinositol437.6TNC, HSPG2, OSM, TIMP3, MMP2, ITGAL
49tyrosine437.3CD80, CD28, CD4, ITGAL, MMP2, HLA-DQB1
50calcium43 49 24 129.7CCL23, TNC, CD28, HSPG2, OSM, TIMP3

GO Terms for genes affiliated with Sialadenitis

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Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.7TIMP3, HSPG2, TNC
2external side of plasma membraneGO:00098978.1TNF, ITGAL, CD4, CD28, CD80
3extracellular spaceGO:00056157.0CCL23, EBI3, TNC, TNFSF13B, TNF, HSPG2
4plasma membraneGO:00058866.1EBI3, HLA-DQB1, TNFSF13B, TNF, HSPG2, MMP2

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of defense response to virus by virusGO:00506909.7CD28, CD4
2positive regulation of calcium-mediated signalingGO:00508509.5CD4, ITGAL
3positive regulation of interleukin-2 biosynthetic processGO:00450869.5CD4, CD28, CD80
4positive regulation of T cell proliferationGO:00421029.4CD28, ITGAL, TNFSF13B
5positive regulation of mitosisGO:00458409.4CD28, TNF
6positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2OSM, CD4, CD80
7positive regulation of alpha-beta T cell proliferationGO:00466419.0CD80, CD28, EBI3
8T cell costimulationGO:00312959.0CD80, CD28, CD4, TNFSF13B, HLA-DQB1
9humoral immune responseGO:00069598.9CD28, TNF, EBI3
10extracellular matrix organizationGO:00301988.9ITGAL, MMP2, HSPG2, TNF, TNC
11immune responseGO:00069558.6HLA-DQB1, TNFSF13B, OSM, CCL23, CD4

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.8TNF, TNFSF13B
2coreceptor activityGO:00150269.3CD80, CD28, CD4
3cytokine activityGO:00051258.4EBI3, TNFSF13B, TNF, OSM
4protein bindingGO:00055156.2EBI3, TNFSF13B, TNF, HSPG2, TIMP3, MMP2

Products for genes affiliated with Sialadenitis

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Sources for Sialadenitis

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3CDC
13ExPASy
14FMA
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23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
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28IUPHAR
29KEGG
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