MCID: SLD003
MIFTS: 59

Sialadenitis malady

Rare diseases, Gastrointestinal diseases, Oral diseases, Endocrine diseases categories
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Summaries for Sialadenitis

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/4/2010

MalaCards: Sialadenitis, also known as sialoadenitis, is related to b-cell lymphomas and hepatitis c. An important gene associated with Sialadenitis is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Cytokines and Inflammatory Response and IL12 signaling mediated by STAT4. The compounds cicaprost and abatacept have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, b cells and t cells, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:65 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Aliases & Classifications for Sialadenitis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

sialadenitis 8 43 10 45 62
sialoadenitis 8 43
salivary gland inflammation 43
adenitis, salivary gland 43
sialoadenitis nos 8


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Disease Ontology8 DOID:10303
MeSH35 D012793
NCIt40 C26882
ICD9CM27 527.2
ICD1025 K11.2

Related Diseases for Sialadenitis

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17GeneCards, 18GeneDecks
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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas30.5TNFSF13B, CD80, ITGAL
2hepatitis c30.5CD28, CD4, TIMP3, HSPG2
3arthritis30.4TNF, OSM
4hodgkin's lymphoma30.3TNFSF13B, CD80, EBI3, CD28
5thyroid cancer30.1TNC, HSPG2, TIMP3
6sjogren's syndrome30.1CD80, CD28, TNFSF13B, HSPG2, ITGAL
7vasculitis29.9TNFSF13B, CD80, TNF
8connective tissue disease29.9CD4, TNF
9t-cell leukemia29.9CD28, CD4, ITGAL
10adenoma29.8TNC, HSPG2, OSM, TIMP3
11tuberculosis29.8ITGAL, TNF, CD4, HLA-DQB1
12sarcoidosis29.7CD28, CD4, TNF, HLA-DQB1, CD80
13rheumatoid arthritis29.7TNFSF13B, TIMP3, MMP2, ITGAL, CD4, CD28
14osteoarthritis29.7TNF, OSM, MMP2, CD80, TIMP3
15leukemia29.7OSM, CD80, CD4, ITGAL, HTR3A, TNF
16xanthogranulomatous sialadenitis10.4
17sialolithiasis10.3
18hepatitis10.3
19dacryoadenitis10.2
20thyroiditis10.2
21retroperitoneal fibrosis10.2
22mumps10.2
23pancreatitis10.2
24hepatitis c virus10.2
25myelitis10.2
26keratoconjunctivitis sicca10.2
27keratoconjunctivitis10.2
28cholangitis10.1
29glomerulonephritis10.1
30obesity10.1
31mikulicz disease10.1
32nodular goiter10.1CD28, CD80
33extrinsic allergic alveolitis10.1CD28, ITGAL
34mast cell neoplasm10.1CD80, ITGAL
35mycobacterium avium complex disease10.1CD4
36listeriosis10.1CD4
37central nervous system lymphoma10.1CD4
38cryptococcosis10.1CD4
39histoplasmosis10.1CD4
40polymyositis10.1CD28, CD80, HSPG2
41common variable immune deficiency10.1CD28, TNFSF13B
42spondylarthropathy10.1ITGAL, TNF
43myocarditis10.1CD4
44b-cell chronic lymphocytic leukemia10.1TNFSF13B, CD80, ITGAL
45arthropathy10.1TNF, OSM
46leishmaniasis10.1CD4
47leprosy10.1CD4
48graft versus host disease10.1CD28, ITGAL, TNF
49pulmonary sarcoidosis10.1TNF, ITGAL, CD80
50non-hodgkin lymphoma10.0CD80, CD28, TNFSF13B, ITGAL

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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Drugs & Therapeutics for Sialadenitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Sialadenitis

Search NIH Clinical Center for Sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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33MalaCards
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MalaCards organs/tissues related to Sialadenitis:

33
Salivary gland, B cells, T cells, Thyroid, Lymph node, Liver, Thymus, Lung, Tongue, Endothelial

Animal Models for Sialadenitis or affiliated genes

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37MGI
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Publications for Sialadenitis

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52PubMed
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Articles related to Sialadenitis:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Salivary endoscopy for idiopathic chronic sialadenitis. (23712592)
2013
2
Prediction of risk for symptomatic sialadenitis by post-therapeutic dual (131)I scintigraphy in patients with differentiated thyroid cancer. (23921836)
2013
3
Superficial parotidectomy for chronic parotid sialadenitis. (22560869)
2013
4
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
5
Pediatric chronic sclerosing sialadenitis: KA1ttner tumor. (21985393)
2012
6
Tenascin-C in chronic sclerosing sialadenitis. (21559807)
2011
7
Sialoendoscopy in the diagnosis and management of obstructive sialadenitis. (21298637)
2011
8
Chronic Sclerosing Sialadenitis (KA1ttner's tumour) of the Parotid Gland. (22135562)
2010
9
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
10
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
11
Pathology quiz case 2. Chronic sclerosing sialadenitis (CSS). (19289717)
2009
12
Concurrent sialocoele and necrotising sialadenitis in a dog. (19261087)
2009
13
Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in SjAPgren's syndrome-associated autoimmune sialadenitis. (19716548)
2009
14
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
15
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
16
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
17
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. (17900348)
2007
18
Surgical treatment of chronic parotid sialadenitis. (17166325)
2007
19
Sialadenitis of the left submandibular gland/sialolith. (16163878)
2005
20
Chronic sclerosing sialadenitis of the parotid gland: diagnosis using color Doppler sonography and sonographically guided needle biopsy. (15784774)
2005
21
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
22
Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice. (15763917)
2004
23
Acute ischemic sialadenitis following facial artery embolization. (15129338)
2004
24
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
25
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
26
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
27
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
28
Subacute necrotizing sialadenitis in the buccal mucosa. (12465016)
2002
29
Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS). (11693172)
2001
30
Lymphoma presenting as parotid xanthogranulomatous sialadenitis. (9881792)
1998
31
Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. (9409649)
1997
32
The case of the second tongue. Acute bacterial sialadenitis of the submandibular glands. (9336598)
1997
33
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
34
On focal lymphocytic sialadenitis as a gold standard for the diagnosis of SjAPgren's syndrome: comment on the article by Daniels and Whitcher. (7779134)
1995
35
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
36
Sialadenitis with crystalloid formation: a report of six cases diagnosed by fine-needle aspiration. (7789253)
1995
37
Immunohistopathological investigation on unspecific chronic sclerosing sialadenitis of the submandibular gland (KA1ttner tumor). (7993223)
1994
38
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
39
Lymphocytic sialadenitis of SjAPgren's syndrome associated with chronic hepatitis C virus liver disease. (1346409)
1992
40
Epidermoid cyst: an unusual cause of obstructive sialadenitis. (1567800)
1992
41
Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction. (2036674)
1991
42
Submandibular sialadenitis presenting as Ludwig's angina. (1782892)
1991
43
Radionuclide imaging of potassium iodide-induced sialadenitis. (3034466)
1987
44
Bilateral obstructive sialadenitis of the submandibular glands due to a denture. (3474000)
1987
45
Sialadenitis in children. (3744701)
1986
46
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
47
Oxyphenbutazone-induced sialadenitis, intrahepatic cholestasis and pancreatitis. (3832725)
1985
48
Contrast induced sialadenitis--a case report. (6544850)
1984
49
Diagnosis please. Benign follicular hyperplasia of a submandibular lymph node and chronic sialadenitis. (4516846)
1973
50
Chronic sialadenitis and sialography. (14370773)
1955

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 5Cell Signaling Technology, 60Thomson Reuters, 12EMD Millipore, 57SinoBiological, 54R&D Systems, 30KEGG
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Pathways related to Sialadenitis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TNF, CD4
29.7CD28, CD4
3
Show member pathways
9.7CD4, CD28
49.6CD28, CD80
59.6CD28, CD80
6
Show member pathways
9.6CD80, CD28
7
Show member pathways
9.6TNFSF13B, TNF, TIMP3
89.6MMP2, TIMP3, TNC
9
Show member pathways
9.6TNC, TIMP3, MMP2
10
Show member pathways
9.5TNF, TNFSF13B, HLA-DQB1
11
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.4CD28, HLA-DQB1, CD4
129.4TNC, ITGAL, HSPG2
13
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4TNF, CD4, MMP2
14
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.4CD80, HSPG2, TNF
15
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.4CD28, TNF, CD4
16
Show member pathways
9.3CD28, CD4, CD80
17
Show member pathways
TCR signaling in naive CD8+ T cells38
9.3CD4, CD80, CD28
18
Show member pathways
9.3HSPG2, TIMP3, MMP2, TNF
199.3HSPG2, TIMP3, TNF, MMP2
20
Show member pathways
9.3EBI3, TNF
21
Show member pathways
9.2HSPG2, TNC, TIMP3, ITGAL
22
Show member pathways
9.1MMP2, TNC, ITGAL, HSPG2
23
Show member pathways
9.0ITGAL, MMP2, TIMP3, TNF
24
Show member pathways
9.0CD80, CD28, CD4, HLA-DQB1
25
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.0CD28, CD80, CD4, HLA-DQB1
26
Show member pathways
9.0CD4, CD28, HLA-DQB1, CD80
27
Show member pathways
9.0CD28, CD80, CD4, HLA-DQB1
28
Show member pathways
8.7HLA-DQB1, CD28, TNF, HSPG2, CD80
29
Show member pathways
8.5HSPG2, MMP2, ITGAL, TNC, CCL23
30
Show member pathways
8.5CD4, HLA-DQB1, CD80, ITGAL, CD28
318.5CD80, CD28, CD4, ITGAL, HLA-DQB1
328.2CD80, CD28, ITGAL, HLA-DQB1, TNF, TNFSF13B
33
Show member pathways
IL27-mediated signaling events38
8.1CD4, EBI3, CD80, CD28, TNF
34
Show member pathways
7.9HLA-DQB1, TIMP3, MMP2, ITGAL, CD4, CD28
35
Show member pathways
7.8TNFSF13B, TNF, CD4, CD28, CD80, ITGAL
36
Show member pathways
7.7TNF, CD80, CD4, ITGAL, CCL23, TIMP3
37
Show member pathways
7.5OSM, TNFSF13B, TNF, CD80, CD4, CCL23
38
Show member pathways
7.3CD4, TIMP3, TNFSF13B, TNF, CD28, CD80
39
Show member pathways
6.8CD80, CD4, ITGAL, TIMP3, OSM, TNF
40
Show member pathways
6.2CD80, TNC, TNF, HSPG2, OSM, TIMP3

Compounds for genes affiliated with Sialadenitis

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45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB, 51PharmGKB, 3BitterDB
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Compounds related to Sialadenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1cicaprost45 2911.0TNF, HSPG2
2abatacept45 1111.0CD80, TNF
3cilomilast4510.0MMP2, TNF
4bcma459.9TNFSF13B, TNF
5go 697645 6110.9TNF, HSPG2, MMP2
6ctla4-ig459.9CD80, CD28
7heparan sulfate45 2410.8CD4, TIMP3, HSPG2, TNC
8blys459.7TNF, TNFSF13B
9rituximab45 51 1111.7CD80, TNF, TNFSF13B
10n-formylmethionyl-leucylphenylalanine459.7TNF, HSPG2, ITGAL
11nickel45 2410.7HLA-DQB1, ITGAL, CD4
12glycosaminoglycan459.6TIMP3, OSM, TNC
13efalizumab45 1110.6ITGAL, TNF
14propranolol45 29 51 24 1113.5ITGAL, HTR3A, MMP2, HSPG2
15chloroquine45 3 51 29 1113.5TNF, ITGAL, CD4
16matrigel459.4MMP2, TIMP3, OSM, TNC
17phorbol459.4CD4, ITGAL, MMP2, TNC
18histamine45 29 2411.4HTR3A, OSM, HSPG2, TNF
19azathioprine45 3 51 1112.3ITGAL, MMP2, OSM
20phosphoinositide459.3TNC, HSPG2, ITGAL, CD28
21prednisolone45 29 1111.2ITGAL, MMP2, TNF
22heparin45 29 24 1112.2CD4, ITGAL, TIMP3, HSPG2, TNC
23oligonucleotide459.2HLA-DQB1, TNC, TIMP3, CD4, CD28
24hyaluronic acid45 2410.2TNC, OSM, MMP2, ITGAL
25pd 98,059459.2TNF, HSPG2, OSM, TIMP3, MMP2
26tgf beta1459.1TNC, TNF, OSM, TIMP3, MMP2
27ionomycin459.1CD80, CD28, ITGAL, TNF
28fibrinogen459.1TNC, TNF, OSM, ITGAL
29h2o2459.1TNC, TNF, HSPG2, MMP2, ITGAL
30ly294002459.0TNC, TNF, HSPG2, TIMP3, MMP2, CD28
31vegf458.9TNC, TNF, HSPG2, OSM, TIMP3, MMP2
32cyclosporin a45 29 6110.8CD80, CD28, ITGAL, TNF
33proline458.8MMP2, ITGAL, CD4, CD28, CD80
34herbimycin a45 619.7TNF, HSPG2, OSM, MMP2, CD4, CD28
35alanine458.7TNFSF13B, HSPG2, OSM, MMP2, ITGAL, CD4
36glutamate458.7HLA-DQB1, TNC, HSPG2, TIMP3, MMP2, ITGAL
37rantes458.5TNF, OSM, CCL23, ITGAL, CD4
38genistein45 29 61 3 24 1113.5TNF, HSPG2, OSM, TIMP3, MMP2, CD4
39wortmannin458.4TNC, HSPG2, TIMP3, MMP2, ITGAL, CD28
40retinoic acid45 249.4TNC, TNF, HSPG2, OSM, TIMP3, MMP2
41cysteine458.2TNC, OSM, TIMP3, MMP2, ITGAL, CD4
42lipid458.2TNC, TNF, OSM, TIMP3, ITGAL, CD4
43oxygen45 249.2TNF, TIMP3, ITGAL, CD28, CD80
44pge2458.1TNF, HSPG2, OSM, MMP2, ITGAL, CD4
45serine457.9TNC, TNF, HSPG2, OSM, MMP2, ITGAL
46cycloheximide457.9TNC, TNF, HSPG2, OSM, MMP2, ITGAL
47dexamethasone45 51 29 1110.6CD80, TNC, TNF, HSPG2, OSM, TIMP3
48phosphatidylinositol457.6TNC, HSPG2, OSM, TIMP3, MMP2, ITGAL
49tyrosine457.3HLA-DQB1, TNC, HSPG2, OSM, TIMP3, MMP2
50calcium45 51 24 119.7TNC, TNFSF13B, HSPG2, OSM, TIMP3, MMP2

GO Terms for genes affiliated with Sialadenitis

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16Gene Ontology
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Cellular components related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.7TIMP3, HSPG2, TNC
2external side of plasma membraneGO:0098978.1TNF, ITGAL, CD4, CD28, CD80
3extracellular spaceGO:0056157.0CCL23, EBI3, TNC, TNFSF13B, TNF, HSPG2
4plasma membraneGO:0058866.1EBI3, HLA-DQB1, TNFSF13B, TNF, HSPG2, MMP2

Biological processes related to Sialadenitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of defense response to virus by virusGO:0506909.7CD28, CD4
2positive regulation of calcium-mediated signalingGO:0508509.5CD4, ITGAL
3positive regulation of interleukin-2 biosynthetic processGO:0450869.5CD4, CD28, CD80
4positive regulation of T cell proliferationGO:0421029.4CD28, ITGAL, TNFSF13B
5positive regulation of mitosisGO:0458409.4CD28, TNF
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2OSM, CD4, CD80
7positive regulation of alpha-beta T cell proliferationGO:0466419.0CD80, CD28, EBI3
8T cell costimulationGO:0312959.0CD80, CD28, CD4, TNFSF13B, HLA-DQB1
9humoral immune responseGO:0069598.9CD28, TNF, EBI3
10extracellular matrix organizationGO:0301988.9ITGAL, MMP2, HSPG2, TNF, TNC
11immune responseGO:0069558.6HLA-DQB1, TNFSF13B, OSM, CCL23, CD4

Molecular functions related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.8TNF, TNFSF13B
2coreceptor activityGO:0150269.3CD80, CD28, CD4
3cytokine activityGO:0051258.4EBI3, TNFSF13B, TNF, OSM
4protein bindingGO:0055156.2EBI3, TNFSF13B, TNF, HSPG2, TIMP3, MMP2

Products for genes affiliated with Sialadenitis

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Sources for Sialadenitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet