MCID: SLD003
MIFTS: 46

Sialadenitis

Categories: Rare diseases, Gastrointestinal diseases, Cardiovascular diseases, Oral diseases, Immune diseases, Endocrine diseases

Aliases & Classifications for Sialadenitis

MalaCards integrated aliases for Sialadenitis:

Name: Sialadenitis 12 50 52 42 14 69
Sialoadenitis 12 50
Salivary Gland Inflammation 50
Adenitis, Salivary Gland 50

Classifications:



External Ids:

Disease Ontology 12 DOID:10303
ICD10 33 K11.2 K11.20
ICD9CM 35 527.2
MeSH 42 D012793
UMLS 69 C0037023

Summaries for Sialadenitis

NIH Rare Diseases : 50 sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. diagnosis is usually made by clinical exam but a ct scan, mri scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. most salivary gland infections go away on their own or are cured with treatment. complications are not common. last updated: 11/8/2016

MalaCards based summary : Sialadenitis, also known as sialoadenitis, is related to lymphoma and xanthogranulomatous sialadenitis, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (TNF Superfamily Member 13b), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Proteoglycans in cancer. The drugs rituximab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Related Diseases for Sialadenitis

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.8 CDSN TNF TNFSF13B TRIM21
2 xanthogranulomatous sialadenitis 12.0
3 igg4-related dacryoadenitis and sialadenitis 12.0
4 mikulicz disease 11.0
5 igg4-related submandibular gland disease 10.8
6 hepatic encephalopathy 10.7 TNC TNF
7 biemond syndrome 10.7 HLA-DQB1 TNF
8 mosaic trisomy 1 10.7 HLA-DQB1 TNF
9 autoimmune retinopathy 10.6 HLA-DQB1 TNF
10 idiopathic dilatation of the pulmonary artery 10.6 HLA-DQB1 TNF
11 limb-body wall complex 10.6 HLA-DQB1 TNF
12 atypical lichen myxedematosus 10.6 HLA-DQB1 TNF
13 lymphocytic colitis 10.6 HLA-DQB1 TNF
14 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.6 HLA-DQB1 TNF
15 limbic encephalitis 10.5 MMP2 TNC
16 tricho onychic dysplasia 10.5 MMP2 TNF
17 charcot-marie-tooth disease, axonal, type 2cc 10.5 MMP2 TIMP3
18 cryptogenic late-onset epileptic spasms 10.5 TNF TRIM21
19 tracheal stenosis 10.5 MMP2 TNF
20 ampulla of vater neoplasm 10.5 HLA-DQB1 TNF
21 cryptococcosis 10.5 HLA-DQB1 TNF
22 idiopathic subglottic tracheal stenosis 10.4 HLA-DQB1 TRIM21
23 benign epilepsy with centrotemporal spikes 10.3 HSPG2 TRIM21
24 anaerobic meningitis 10.3 HLA-DQB1 TNF
25 advanced sleep phase syndrome, familial, 1 10.3 HLA-DQB1 TNF TNFSF13B
26 pericholangitis 10.3 CDSN TNF
27 pancreatoblastoma 10.3 TIMP3 TNC
28 moderately severe hemophilia b 10.3 HLA-DQB1 TNF
29 pulmonary nodular lymphoid hyperplasia, familial 10.3 CDSN TRIM21
30 lacrimal system cancer 10.2 TNF TNFSF13B TRIM21
31 pseudohypoparathyroidism 10.2 TNF TNFSF13B TRIM21
32 loeffler syndrome 10.2 AQP5 HSPG2
33 achard syndrome 10.1 CDSN TRIM21
34 laron dwarfism 10.1 AQP5 HSPG2
35 early congenital syphilis 10.1 HSPG2 TNF TRIM21
36 benign lymphoepithelial lesion of salivary gland 10.1 HSPG2 TNFSF13B TRIM21
37 sialolithiasis 10.0
38 dacryoadenitis 10.0
39 dysphagia 10.0 RAG1 TNF
40 human monocytic ehrlichiosis 10.0 HLA-DQB1 TNF
41 hepatitis c 9.9
42 pancreatitis 9.9
43 hepatitis 9.9
44 ceruminous carcinoma 9.9 RAG1 TNF
45 dry eye syndrome 9.9 CDSN HSPG2 TRIM21
46 thyroiditis 9.9
47 b-cell lymphomas 9.9
48 congenital symblepharon 9.8 RAG1 TNF TNFSF13B
49 retroperitoneal fibrosis 9.8
50 arthritis 9.8

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Mucocele of Salivary Gland Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to Sialadenitis

Symptoms & Phenotypes for Sialadenitis

UMLS symptoms related to Sialadenitis:


salivary gland pain

MGI Mouse Phenotypes related to Sialadenitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 HLA-DQB1 HSPG2 HTR3A MMP2 RAG1 TIMP3
2 homeostasis/metabolism MP:0005376 10.02 AQP5 HLA-DQB1 HSPG2 HTR3A MMP2 RAG1
3 behavior/neurological MP:0005386 10.01 AQP5 HLA-DQB1 HSPG2 HTR3A RAG1 TIMP3
4 immune system MP:0005387 9.91 RAG1 TIMP3 TNF TNFSF13B TRIM21 HLA-DQB1
5 muscle MP:0005369 9.7 AQP5 HLA-DQB1 HSPG2 HTR3A MMP2 TIMP3
6 respiratory system MP:0005388 9.5 AQP5 HLA-DQB1 HSPG2 MMP2 RAG1 TIMP3
7 vision/eye MP:0005391 9.1 AQP5 HSPG2 MMP2 RAG1 TIMP3 TNF

Drugs & Therapeutics for Sialadenitis

Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Antibodies Phase 1, Phase 2
3 Antirheumatic Agents Phase 1, Phase 2
4 Immunoglobulins Phase 1, Phase 2
5 Vaccines Phase 2
6
Acetaminophen Approved 103-90-2 1983
7
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
8
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
9
Lidocaine Approved, Vet_approved 137-58-6 3676
10
Morphine Approved, Investigational 57-27-2 5288826
11 Analgesics
12 Analgesics, Non-Narcotic
13 Anesthetics
14 Anesthetics, Local
15 Anti-Arrhythmia Agents
16 Anti-Inflammatory Agents
17 Anti-Inflammatory Agents, Non-Steroidal
18 Antipyretics
19 Central Nervous System Depressants
20 dipyrone
21 Diuretics, Potassium Sparing
22 Peripheral Nervous System Agents
23 Pharmaceutical Solutions
24 Proxymetacaine
25 Sodium Channel Blockers
26 Analgesics, Opioid
27 Narcotics

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Dental Safety Profile of High-Dose Radioiodine Therapy Completed NCT00439478 Phase 4 Radioiodine
2 Rituximab in IgG4-RD: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
3 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Active, not recruiting NCT03133923 Phase 2
4 SPI-directed Analgesia for Vitreoretinal Surgeries Completed NCT02973581 Metamizol;Acetaminophen;0,5 % bupivacaine with of 2% lidocaine;Proxymetacaine
5 The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer Recruiting NCT01833650
6 A Prospective Cohort Study of IgG4RD in China Recruiting NCT01670695
7 Imaging Study of 3D-CBCT Sialography and MRI Sialography in Non Tumor Salivary Diseases Not yet recruiting NCT02883140
8 Gender and Opioid Consumption Not yet recruiting NCT03006627 postoperative morphine

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

Genetic Tests for Sialadenitis

Anatomical Context for Sialadenitis

MalaCards organs/tissues related to Sialadenitis:

39
Salivary Gland, T Cells, Thyroid, B Cells, Lymph Node, Liver, Tongue

Publications for Sialadenitis

Articles related to Sialadenitis:

(show top 50) (show all 477)
id Title Authors Year
1
Differentiating (131)I Radiation Sialadenitis From Autoimmune (SjAPgren Syndrome) Sialadenitis: Case Report. ( 28499805 )
2017
2
A review of acute postoperative sialadenitis in children. ( 28012533 )
2017
3
Highlight: Understanding radiation sialadenitis. ( 28588084 )
2017
4
Chronic sialadenitis due to the stone inside the accessory duct of submandibular gland. ( 28337530 )
2017
5
Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review. ( 28949251 )
2017
6
Anterior mandibular rehabilitation causing chronic obstructive sialadenitis: ?A series of sialo-CBCT cases and literature review. ( 28740970 )
2017
7
Flagellar filament structural protein induces SjAPgren's syndrome-like sialadenitis in mice. ( 28142222 )
2017
8
Diffusion-weighted MRI for differentiation between sialadenitis and pleomorphic adenoma. ( 27845594 )
2017
9
Pathogenic role of endogenous TNF-I+ in the development of SjAPgren's-like sialadenitis and secretory dysfunction in non-obese diabetic mice. ( 28067896 )
2017
10
Acute sialadenitis as adverse reaction to iodinated contrast. ( 28619517 )
2017
11
Surgeon-Performed Ultrasound for Chronic Obstructive Sialadenitis Helps Predict Sialendoscopic Findings and Outcomes. ( 28871894 )
2017
12
Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature. ( 28516348 )
2017
13
Sialendoscopic management of autoimmune sialadenitis: a review of literature. ( 28516978 )
2017
14
Imaging of sialadenitis. ( 28059621 )
2017
15
18F-FDG PET/CT Features of Chronic Sclerosing Sialadenitis Presenting as Localized IgG4-Related Disease. ( 28060780 )
2017
16
Combined interventional sialendoscopy and intraductal steroid therapy for recurrent sialadenitis in SjAPgren's syndrome: Results of a pilot monocentric trial. ( 28585263 )
2017
17
Iodide-Associated Sialadenitis. ( 28249137 )
2017
18
IgG4-related sclerosing cholangitis and chronic sclerosing sialadenitis mimicking cholangiocarcinoma and neck malignancy. ( 28823378 )
2017
19
Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis? ( 28516979 )
2017
20
Bilateral submandibular sialadenitis following influenza A virus infection. ( 28924556 )
2017
21
Chronic sialadenitis with sialolithiasis associated with parapharyngeal fistula and tonsillolith. ( 28828116 )
2017
22
Acute unilateral post-operative submandibular sialadenitis following posterior cranial fossa surgery. ( 28584354 )
2017
23
Sialadenitis following blepharoplasty: An unusual sequelae. ( 28513497 )
2017
24
RORI^t antagonist suppresses M3 muscarinic acetylcholine receptor-induced SjAPgren's syndrome-like sialadenitis. ( 27643385 )
2016
25
Sialendoscopy-assisted surgery and the chronic obstructive sialadenitis symptoms questionnaire: A prospective study. ( 26972293 )
2016
26
Acute postoperative sialadenitis after retrosigmoid craniotomies. ( 27402408 )
2016
27
Uncommon situation and presentation of chronic sclerosing sialadenitis. ( 26968047 )
2016
28
Captopril-induced sialadenitis in a patient with end-stage renal disease. ( 27162811 )
2016
29
Imaging findings of obstructive sialadenitis due to an intraglandular foreign body. ( 27622423 )
2016
30
Reply to letter "Therapeutic ductal injection in chronic sialadenitis is established". ( 27637754 )
2016
31
Masseteric Myositis: A Unique Cause of Obstructive Sialadenitis of Parotid Gland. ( 28068299 )
2016
32
Clinicopathology of Immunoglobulin G4-Related Chronic Sclerosing Sialadenitis: A Single-Center Study. ( 27576683 )
2016
33
Diagnostic Challenges in the Fine Needle Aspiration Biopsy of Chronic Sclerosing Sialadenitis (KA1ttner's Tumor) in the Context of Head and Neck Malignancy: A Series of 4 Cases. ( 26909791 )
2016
34
Persistence of focal lymphocytic sialadenitis in patients with primary SjAPgren's syndrome treated with rituximab: a possible role for glandular BAFF. ( 27494407 )
2016
35
IgG4-related sialadenitis and SjAPgren's syndrome. ( 27318181 )
2016
36
Massive sialadenitis resulting in critical airway after elective craniotomy: case report. ( 27258589 )
2016
37
IgG4 related sclerosing sialadenitis- a retrospective analysis. ( 27568667 )
2016
38
Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis. ( 27822398 )
2016
39
Geographic tongue associated with sialadenitis. ( 27726175 )
2016
40
The role of interventional sialendoscopy and intraductal steroid therapy in patients with recurrent sine causa sialadenitis: a prospective cross-sectional study. ( 27200511 )
2016
41
Diagnostic Utility of Acoustic Structure Quantification for Evaluation of Radiation Sialadenitis after Radioactive Iodine Therapy. ( 27543124 )
2016
42
Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy-assisted salivary duct surgery. ( 27701754 )
2016
43
Subacute Necrotizing Sialadenitis: A Series of Three Cases and Literature Review. ( 27008639 )
2016
44
Therapeutic ductal injection in chronic sialadenitis is established. ( 27619821 )
2016
45
Differential diagnosis of IgG4-related sialadenitis, primary SjAPgren syndrome, and chronic obstructive submandibular sialadenitis. ( 27866757 )
2016
46
Tubercular sialadenitis of parotid gland - An extremely rare case series. ( 27998500 )
2016
47
Sonographic findings of immunoglobulin G4-related sclerosing sialadenitis. ( 26707999 )
2016
48
Lipoma of the cheek presenting with recurrent sialadenitis of the right parotid gland: a case report. ( 27809889 )
2016
49
Sialendoscopy in sialadenitis: an unselected cohort of 228 patients. ( 26333199 )
2015
50
Ultrasonographic Features of Immunoglobulin G4-RelatedA Sialadenitis. ( 26518180 )
2015

Variations for Sialadenitis

Expression for Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for Sialadenitis

Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 HLA-DQB1 MMP2 RAG1 TNF TNFSF13B TRIM21
2 11.56 HSPG2 MMP2 TIMP3 TNF
3 11.39 HLA-DQB1 TNF TNFSF13B
4 11.27 MMP2 TIMP3 TNC
5
Show member pathways
10.92 HSPG2 MMP2 TIMP3 TNF

GO Terms for Sialadenitis

Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 HSPG2 MMP2 TIMP3 TNC TNF TNFSF13B
2 proteinaceous extracellular matrix GO:0005578 9.46 HSPG2 MMP2 TIMP3 TNC
3 extracellular matrix GO:0031012 9.26 HSPG2 MMP2 TIMP3 TNC
4 basement membrane GO:0005604 8.8 HSPG2 TIMP3 TNC

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.33 HSPG2 TNC TNF
2 immune response GO:0006955 9.26 HLA-DQB1 RAG1 TNF TNFSF13B
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.62 MMP2 TNF

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 TNF TNFSF13B

Sources for Sialadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....