MCID: SLD003
MIFTS: 50

Sialadenitis malady

Gastrointestinal, Endocrine categories

Summaries for Sialadenitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/4/2010

MalaCards: Sialadenitis, also known as sialoadenitis, is related to arthritis and hepatitis c. An important gene associated with Sialadenitis is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Immune response NFAT in immune response and Immune response ICOS pathway in T-helper cell. The compounds cycloheximide and thymoglobulin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thymus and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Wikipedia:64 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Aliases & Classifications for Sialadenitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Endocrine


Aliases & Descriptions:

sialadenitis 8 43 10 45 61
sialoadenitis 8 43
salivary gland inflammation 43
adenitis, salivary gland 43
sialoadenitis nos 8


External Ids:

Disease Ontology8 DOID:10303
MeSH35 D012793
NCIt40 C26882
ICD9CM27 527.2
ICD1025 K11.2

Related Diseases for Sialadenitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.3CD80, TIMP3, OSM
2hepatitis c30.3PTPRC, CD28, TNFSF13B, CALR, TIMP3
3sjogren's syndrome30.1CALR, TNFSF13B, ITGAL, CD80, SSB, CD28
4thyroid cancer30.0TIMP3, HSPG2, TNC
5nephritis29.8TNFSF13B
6vasculitis29.8CD80, TNFSF13B
7osteoarthritis29.8TIMP3, CD80, OSM
8primary biliary cirrhosis29.8HSPG2, CALR, ITGAL
9tuberculosis29.8CALR, HLA-DQB1, ITGAL, PTPRC
10xanthogranulomatous sialadenitis10.4
11sialolithiasis10.3
12mumps10.3
13n syndrome10.2
14retroperitoneal fibrosis10.2
15hepatitis d10.2
16myelitis10.2
17keratoconjunctivitis sicca10.2
18devic disease10.2
19follicular lymphoma10.1
20anhidrosis10.0
21chronic dacryoadenitis10.0
22acquired immunodeficiency syndrome10.0
23sclerosing cholangitis10.0
24hepatitis c virus10.0
25hepatitis10.0HSPG2
26pancreatitis10.0HSPG2
27connective tissue disease10.0TROVE2
28systemic lupus erythematosus10.0TNFSF13B
29dry eye syndrome10.0HSPG2
30diabetic retinopathy10.0TIMP3
31proliferative diabetic retinopathy10.0TIMP3
32lymphoma, malt, somatic10.0CD80
33dementia10.0HTR3A
34wegener's granulomatosis10.0CD28, CD80
35purpura10.0HSPG2
36stomach cancer10.0TIMP3, CD80
37glomerulonephritis10.0ITGAL, CD28
38polymyositis10.0CD80, CD28, HSPG2
39dermatomyositis10.0TROVE2, HSPG2, CD28
40lupus erythematosus10.0TROVE2, CALR
41osteosarcoma10.0HSPG2, OSM
42severe combined immunodeficiency10.0PTPRC
43hepatitis b10.0CD80, ITGAL, HLA-DQB1
44pulmonary fibrosis10.0OSM, TNC
45psoriasis10.0OSM, CD28, ITGAL
46hypersensitivity reaction type ii disease10.0HSPG2, HLA-DQB1, CD80
47diabetes mellitus10.0HLA-DQB1, CALR
48myositis10.0CD28, PTPRC
49dilated cardiomyopathy10.0CALR, HLA-DQB1
50common variable immune deficiency10.0CD28, TNFSF13B

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Clinical Features for Sialadenitis

Drugs & Therapeutics for Sialadenitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sialadenitis

Drug clinical trials:

Search ClinicalTrials for Sialadenitis

Search NIH Clinical Center for Sialadenitis

Search CenterWatch for Sialadenitis

Genetic Tests for Sialadenitis

Anatomical Context for Sialadenitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Sialadenitis:

33
Lymph node, Thymus, Liver, Lung, Thyroid, Salivary gland, T cells, B cells, Endothelial, Tongue

Animal Models for Sialadenitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Sialadenitis

Sources:
51PubMed
See all sources

Articles related to Sialadenitis:

(show top 50)    (show all 373)
idTitleAuthorsYear
1
Prediction of risk for symptomatic sialadenitis by post-therapeutic dual (131)I scintigraphy in patients with differentiated thyroid cancer. (23921836)
2013
2
Clinical and pathological characteristics of IgG4-related sclerosing sialadenitis. (22241660)
2012
3
Acute sialadenitis secondary to submandibular calculi after botulinum neurotoxin injection for sialorrhea in a child with cerebral palsy. (22019967)
2011
4
Primary non-Hodgkin's lymphoma of the salivary gland: a spectrum of lymphoepithelial sialadenitis, low-grade B-cell lymphoma of mucosa-associated lymphoid tissue with transformation to high-grade lymphoma. (20551561)
2010
5
Neonatal hyperthyroidism associated with isolated submandibular sialadenitis: is it just a coincidence? (21274336)
2010
6
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
7
A clinico-pathologic correlation. Subacute necrotizing sialadenitis. (19526914)
2009
8
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
9
Kuttner's tumour (chronic sclerosing sialadenitis) of the submandibular gland: a clinical perspective. (18239243)
2008
10
Close correlation between chronic sclerosing sialadenitis and immunoglobulin G4. (16866659)
2006
11
Nonionic contrast media induced sialadenitis following coronary angiography. (16943115)
2006
12
Neonatal suppurative submandibular sialadenitis. (15818303)
2005
13
Acute sialadenitis after percutaneous coronary intervention. (15243768)
2004
14
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
15
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
16
Subacute necrotizing sialadenitis in the buccal mucosa. (12465016)
2002
17
True primary SjAPgren's syndrome in a subset of patients with hepatitis C infection: a model linking chronic infection to chronic sialadenitis. (12516900)
2002
18
The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross. (11782015)
2002
19
Management of non-tuberculous mycobacterial peri-sialadenitis in children: the Sheffield otolaryngology experience. (11437850)
2001
20
Neonatal submandibular suppurative sialadenitis. (11079207)
2000
21
Subacute necrotizing sialadenitis: report of 7 cases and a review of the literature. (10807718)
2000
22
Lymphoepithelial duct lesions in SjAPgren-type sialadenitis. (10335942)
1999
23
Persistent sialadenitis after radioactive iodine therapy: report of two cases. (10368102)
1999
24
Sialadenitis and sialolithiasis. (10513110)
1999
25
Xanthogranulomatous sialadenitis following diagnosis of Warthin's tumour: a possible complication of fine needle aspiration (FNA). (10458505)
1999
26
Severe CMV sialadenitis in adults is not always an opportunistic infection of AIDS. (9089035)
1997
27
Role of microliths in the aetiology of chronic submandibular sialadenitis: a clinicopathological investigation of 154 cases. (9354894)
1997
28
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
29
Sialadenitis with crystalloid formation: a report of six cases diagnosed by fine-needle aspiration. (7789253)
1995
30
Detection of cytomegalovirus and Epstein-Barr virus in labial salivary glands in Sjogren's syndrome and non-specific sialadenitis. (7473264)
1995
31
Autoimmune sialadenitis: a form of onset of SjAPgren's syndrome? (7653940)
1995
32
Biased T cell receptor V beta gene usage during specific stages of the development of autoimmune sialadenitis in the MRL/lpr mouse model of SjAPgren's syndrome. (7639803)
1995
33
Obstructive sialadenitis: a rat model. (8170021)
1994
34
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
35
Progression of sialadenitis in SjAPgren's syndrome. (8339128)
1993
36
Faulty major histocompatibility complex class II I-E expression is associated with autoimmunity in diverse strains of mice. Autoantibodies, insulitis, and sialadenitis. (8325448)
1993
37
Epidermoid cyst: an unusual cause of obstructive sialadenitis. (1567800)
1992
38
Experimental autoallergic sialadenitis in the LEW rat. II. Target antigens are associated with cell surface and intracellular particulate fractions derived from the submandibular gland. (2036675)
1991
39
An animal model of autoimmune sialadenitis in aged mice. (2740281)
1989
40
Effects of immunomodulating treatment on autoimmune sialadenitis in MRL/Mp-lpr/lpr mice. (3218611)
1988
41
Ciliated cells in the main excretory duct of the submandibular gland in obstructive sialadenitis: a SEM and TEM study. (3824561)
1987
42
Immunohistochemical characterization of sialadenitis in NZB X NZW F1 mice. (3791713)
1987
43
Ultrastructural and histochemical observations on microcalculi in chronic submandibular sialadenitis. (3127566)
1987
44
Bilateral recurrent submandibular obstructive sialadenitis. (3858469)
1985
45
Development of malignant lymphoma in myoepithelial sialadenitis (SjAPgren's syndrome). (7043890)
1982
46
Salivary calculi as an aetiological factor in chronic sialadenitis of the submandibular gland. (7127874)
1982
47
Ciliated ductal cells in obstructive sialadenitis. (7299810)
1981
48
Chronic obstructive sialadenitis. (5277383)
1971
49
Unusual foreign body etiology of sialadenitis. (6029349)
1967
50
Chronic obstructive sialadenitis of the sublingual gland. Report of a case. (13703614)
1960

Genetic Variations for Sialadenitis

Expression for genes affiliated with Sialadenitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

Sources:
12EMD Millipore, 54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 53R&D Systems, 30KEGG
See all sources

Pathways related to Sialadenitis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response NFAT in immune response
Hide members
9.7CD28, CD80, HLA-DQB1
2
Immune response ICOS pathway in T-helper cell
Hide members
9.7CD28, HLA-DQB1, CD80
3
Hide members
9.7HLA-DQB1, CD80, CD28
4
Hide members
9.7CD28, PTPRC, CD80
5
Hide members
9.6EBI3, CD80, CD28
69.5ITGAL, CD28, CD80, TNFSF13B
7
Hide members
9.5TNC, PLA2G3, ITGAL, TIMP3, HSPG2
89.3AMY1A, AMY1B, AMY1C
9
Hide members
9.3PTPRC, PLA2G3, HLA-DQB1, CD80, CD28
10
Hide members
9.3TNFSF13B, CCL23, CD80, ITGAL, TIMP3
11
Hide members
9.3CD80, CD28, TIMP3, HLA-DQB1, ITGAL
129.2HLA-DQB1, ITGAL, CD80, PTPRC, CD28
13
Hide members
9.0ITGAL, CALR, CD28, CD80, HLA-DQB1, TNFSF13B
14
Hide members
9.0CD80, TROVE2, SSB, CD28, HLA-DQB1
15
Hide members
8.5CCL23, TNFSF13B, ITGAL, CD28, CD80, OSM
16
Hide members
8.4PTPRC, PLA2G3, CD28, TIMP3, TNFSF13B, CD80
17
Hide members
8.2CCL23, TNC, TNFSF13B, ITGAL, TIMP3, HSPG2

Compounds for genes affiliated with Sialadenitis

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Sialadenitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.6HSPG2
2thymoglobulin4510.2CD28, PTPRC
3ctla4-ig4510.1CD80, CD28
4propranolol45 29 50 11 2414.0ITGAL, HSPG2, HTR3A
5serine459.9OSM
6heparin45 29 11 2412.7TIMP3, PTPRC, ITGAL, CALR, HSPG2
7glycosaminoglycan459.6OSM, TIMP3, TNC
8herbimycin a45 6010.6PTPRC, OSM, CD28, HSPG2
9phosphoinositide459.6HSPG2, CALR, TNC, ITGAL, CD28
10hyaluronic acid45 2410.6PTPRC, ITGAL, OSM, TNC
11ionomycin459.5ITGAL, CALR, CD80, CD28, PTPRC
12histamine45 29 2411.5PTPRC, CALR, HTR3A, OSM, HSPG2
13wortmannin459.4CD80, ITGAL, CD28, TNC, TIMP3, HSPG2
14h2o2459.4TNC, HSPG2, CALR, ITGAL, PTPRC
15genistein45 29 60 2 11 2414.4OSM, TIMP3, HSPG2, CD28, PTPRC
16oligonucleotide459.3TIMP3, TNC, CALR, HLA-DQB1, CD28
17ly294002459.3TIMP3, TNC, CD28, HSPG2
18retinoic acid45 2410.1TIMP3, OSM, TNC, CALR, HSPG2, ITGAL
19dexamethasone45 50 29 1112.0OSM, CALR, ITGAL, CD80, PTPRC, HTR3A
20cysteine458.9ITGAL, TIMP3, CALR, TNC, OSM, CD28
21lipid458.8TIMP3, TNC, OSM, ITGAL, CD28, PTPRC
22phosphatidylinositol458.8HSPG2, TIMP3, PTPRC, CD28, CD80, ITGAL
23tyrosine458.3ITGAL, CD28, HSPG2, TIMP3, PTPRC, HLA-DQB1
24calcium45 50 11 2410.5CD28, PLA2G3, PTPRC, CD80, ITGAL, TNC

GO Terms for genes affiliated with Sialadenitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9ITGAL, CD80, CD28, PTPRC, CALR
2extracellular spaceGO:0056158.3PLA2G3, HSPG2, CCL23, CALR, TNC, TNFSF13B
3plasma membraneGO:0058868.1EBI3, PTPRC, PLA2G3, CD28, HSPG2, TNFSF13B

Biological processes related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-2 biosynthetic processGO:0450869.6CD28, CD80
2positive regulation of alpha-beta T cell proliferationGO:0466419.6CD28, CD80, EBI3
3positive regulation of T cell proliferationGO:0421029.6PTPRC, CD28, ITGAL, TNFSF13B
4T cell costimulationGO:0312959.4TNFSF13B, HLA-DQB1, CD80, CD28
5immune responseGO:0069559.3HLA-DQB1, OSM, TNFSF13B, CCL23

Products for genes affiliated with Sialadenitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sialadenitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet