MCID: SLD003
MIFTS: 59

Sialadenitis malady

Rare diseases, Gastrointestinal diseases, Oral diseases, Endocrine diseases categories

Summaries for Sialadenitis

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/4/2010

MalaCards: Sialadenitis, also known as sialoadenitis, is related to b-cell lymphomas and hepatitis c. An important gene associated with Sialadenitis is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Cytokines and Inflammatory Response and IL12 signaling mediated by STAT4. The compounds cicaprost and abatacept have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, b cells and t cells, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:66 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Aliases & Classifications for Sialadenitis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 28ICD9CM, 26ICD10
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Classifications:



Aliases & Descriptions:

sialadenitis 9 44 11 46 63
sialoadenitis 9 44
salivary gland inflammation 44
adenitis, salivary gland 44
sialoadenitis nos 9


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Disease Ontology9 DOID:10303
MeSH36 D012793
NCIt41 C26882
ICD9CM28 527.2
ICD1026 K11.2

Related Diseases for Sialadenitis

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18GeneCards, 19GeneDecks
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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas30.5TNFSF13B, CD80, ITGAL
2hepatitis c30.5CD28, CD4, TIMP3, HSPG2
3arthritis30.4TNF, OSM
4hodgkin's lymphoma30.3TNFSF13B, CD80, EBI3, CD28
5thyroid cancer30.1TNC, HSPG2, TIMP3
6sjogren's syndrome30.1CD80, CD28, TNFSF13B, HSPG2, ITGAL
7vasculitis29.9TNFSF13B, CD80, TNF
8connective tissue disease29.9CD4, TNF
9t-cell leukemia29.9CD28, CD4, ITGAL
10adenoma29.8TNC, HSPG2, OSM, TIMP3
11tuberculosis29.8ITGAL, TNF, CD4, HLA-DQB1
12sarcoidosis29.7CD28, CD4, TNF, HLA-DQB1, CD80
13rheumatoid arthritis29.7TNFSF13B, TIMP3, MMP2, ITGAL, CD4, CD28
14osteoarthritis29.7TNF, OSM, MMP2, CD80, TIMP3
15leukemia29.7OSM, CD80, CD4, ITGAL, HTR3A, TNF
16xanthogranulomatous sialadenitis10.4
17sialolithiasis10.3
18hepatitis10.3
19dacryoadenitis10.2
20thyroiditis10.2
21retroperitoneal fibrosis10.2
22mumps10.2
23pancreatitis10.2
24hepatitis c virus10.2
25myelitis10.2
26keratoconjunctivitis sicca10.2
27keratoconjunctivitis10.2
28cholangitis10.1
29glomerulonephritis10.1
30obesity10.1
31mikulicz disease10.1
32nodular goiter10.1CD28, CD80
33extrinsic allergic alveolitis10.1CD28, ITGAL
34mast cell neoplasm10.1CD80, ITGAL
35mycobacterium avium complex disease10.1CD4
36listeriosis10.1CD4
37central nervous system lymphoma10.1CD4
38cryptococcosis10.1CD4
39histoplasmosis10.1CD4
40polymyositis10.1CD28, CD80, HSPG2
41common variable immune deficiency10.1CD28, TNFSF13B
42spondylarthropathy10.1ITGAL, TNF
43myocarditis10.1CD4
44b-cell chronic lymphocytic leukemia10.1TNFSF13B, CD80, ITGAL
45arthropathy10.1TNF, OSM
46leishmaniasis10.1CD4
47leprosy10.1CD4
48graft versus host disease10.1CD28, ITGAL, TNF
49pulmonary sarcoidosis10.1TNF, ITGAL, CD80
50non-hodgkin lymphoma10.0CD80, CD28, TNFSF13B, ITGAL

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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Drugs & Therapeutics for Sialadenitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Sialadenitis

Drug clinical trials:

Search ClinicalTrials for Sialadenitis

Search NIH Clinical Center for Sialadenitis

Search CenterWatch for Sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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34MalaCards
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MalaCards organs/tissues related to Sialadenitis:

34
Salivary gland, B cells, T cells, Thyroid, Lymph node, Liver, Thymus, Lung, Tongue, Endothelial

Animal Models for Sialadenitis or affiliated genes

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38MGI
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Publications for Sialadenitis

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53PubMed
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Articles related to Sialadenitis:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Salivary endoscopy for idiopathic chronic sialadenitis. (23712592)
2013
2
Prediction of risk for symptomatic sialadenitis by post-therapeutic dual (131)I scintigraphy in patients with differentiated thyroid cancer. (23921836)
2013
3
Superficial parotidectomy for chronic parotid sialadenitis. (22560869)
2013
4
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
5
Pediatric chronic sclerosing sialadenitis: KA1ttner tumor. (21985393)
2012
6
Tenascin-C in chronic sclerosing sialadenitis. (21559807)
2011
7
Sialoendoscopy in the diagnosis and management of obstructive sialadenitis. (21298637)
2011
8
Chronic Sclerosing Sialadenitis (KA1ttner's tumour) of the Parotid Gland. (22135562)
2010
9
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
10
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
11
Pathology quiz case 2. Chronic sclerosing sialadenitis (CSS). (19289717)
2009
12
Concurrent sialocoele and necrotising sialadenitis in a dog. (19261087)
2009
13
Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in SjAPgren's syndrome-associated autoimmune sialadenitis. (19716548)
2009
14
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
15
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
16
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
17
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. (17900348)
2007
18
Surgical treatment of chronic parotid sialadenitis. (17166325)
2007
19
Sialadenitis of the left submandibular gland/sialolith. (16163878)
2005
20
Chronic sclerosing sialadenitis of the parotid gland: diagnosis using color Doppler sonography and sonographically guided needle biopsy. (15784774)
2005
21
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
22
Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice. (15763917)
2004
23
Acute ischemic sialadenitis following facial artery embolization. (15129338)
2004
24
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
25
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
26
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
27
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
28
Subacute necrotizing sialadenitis in the buccal mucosa. (12465016)
2002
29
Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS). (11693172)
2001
30
Lymphoma presenting as parotid xanthogranulomatous sialadenitis. (9881792)
1998
31
Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. (9409649)
1997
32
The case of the second tongue. Acute bacterial sialadenitis of the submandibular glands. (9336598)
1997
33
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
34
On focal lymphocytic sialadenitis as a gold standard for the diagnosis of SjAPgren's syndrome: comment on the article by Daniels and Whitcher. (7779134)
1995
35
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
36
Sialadenitis with crystalloid formation: a report of six cases diagnosed by fine-needle aspiration. (7789253)
1995
37
Immunohistopathological investigation on unspecific chronic sclerosing sialadenitis of the submandibular gland (KA1ttner tumor). (7993223)
1994
38
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
39
Lymphocytic sialadenitis of SjAPgren's syndrome associated with chronic hepatitis C virus liver disease. (1346409)
1992
40
Epidermoid cyst: an unusual cause of obstructive sialadenitis. (1567800)
1992
41
Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction. (2036674)
1991
42
Submandibular sialadenitis presenting as Ludwig's angina. (1782892)
1991
43
Radionuclide imaging of potassium iodide-induced sialadenitis. (3034466)
1987
44
Bilateral obstructive sialadenitis of the submandibular glands due to a denture. (3474000)
1987
45
Sialadenitis in children. (3744701)
1986
46
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
47
Oxyphenbutazone-induced sialadenitis, intrahepatic cholestasis and pancreatitis. (3832725)
1985
48
Contrast induced sialadenitis--a case report. (6544850)
1984
49
Diagnosis please. Benign follicular hyperplasia of a submandibular lymph node and chronic sialadenitis. (4516846)
1973
50
Chronic sialadenitis and sialography. (14370773)
1955

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 5Cell Signaling Technology, 61Thomson Reuters, 13EMD Millipore, 58SinoBiological, 55R&D Systems, 31KEGG
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Pathways related to Sialadenitis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TNF, CD4
29.7CD28, CD4
3
Show member pathways
9.7CD4, CD28
49.6CD28, CD80
59.6CD28, CD80
6
Show member pathways
9.6CD80, CD28
7
Show member pathways
9.6TNFSF13B, TNF, TIMP3
89.6MMP2, TIMP3, TNC
9
Show member pathways
9.6TNC, TIMP3, MMP2
10
Show member pathways
9.5TNF, TNFSF13B, HLA-DQB1
11
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.4CD28, HLA-DQB1, CD4
129.4TNC, ITGAL, HSPG2
13
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.4TNF, CD4, MMP2
14
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.4CD80, HSPG2, TNF
15
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.4CD28, TNF, CD4
16
Show member pathways
9.3CD28, CD4, CD80
17
Show member pathways
TCR signaling in naive CD8+ T cells39
9.3CD4, CD80, CD28
18
Show member pathways
9.3HSPG2, TIMP3, MMP2, TNF
199.3HSPG2, TIMP3, TNF, MMP2
20
Show member pathways
9.3EBI3, TNF
21
Show member pathways
9.2HSPG2, TNC, TIMP3, ITGAL
22
Show member pathways
9.1MMP2, TNC, ITGAL, HSPG2
23
Show member pathways
9.0ITGAL, MMP2, TIMP3, TNF
24
Show member pathways
9.0CD80, CD28, CD4, HLA-DQB1
25
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
9.0CD28, CD80, CD4, HLA-DQB1
26
Show member pathways
9.0CD4, CD28, HLA-DQB1, CD80
27
Show member pathways
9.0CD28, CD80, CD4, HLA-DQB1
28
Show member pathways
8.7HLA-DQB1, CD28, TNF, HSPG2, CD80
29
Show member pathways
8.5HSPG2, MMP2, ITGAL, TNC, CCL23
30
Show member pathways
8.5CD4, HLA-DQB1, CD80, ITGAL, CD28
318.5CD80, CD28, CD4, ITGAL, HLA-DQB1
328.2CD80, CD28, ITGAL, HLA-DQB1, TNF, TNFSF13B
33
Show member pathways
IL27-mediated signaling events39
8.1CD4, EBI3, CD80, CD28, TNF
34
Show member pathways
7.9HLA-DQB1, TIMP3, MMP2, ITGAL, CD4, CD28
35
Show member pathways
7.8TNFSF13B, TNF, CD4, CD28, CD80, ITGAL
36
Show member pathways
7.7TNF, CD80, CD4, ITGAL, CCL23, TIMP3
37
Show member pathways
7.5OSM, TNFSF13B, TNF, CD80, CD4, CCL23
38
Show member pathways
7.3CD4, TIMP3, TNFSF13B, TNF, CD28, CD80
39
Show member pathways
6.8CD80, CD4, ITGAL, TIMP3, OSM, TNF
40
Show member pathways
6.2CD80, TNC, TNF, HSPG2, OSM, TIMP3

Compounds for genes affiliated with Sialadenitis

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46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Sialadenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1cicaprost46 3011.0TNF, HSPG2
2abatacept46 1211.0CD80, TNF
3cilomilast4610.0MMP2, TNF
4bcma469.9TNFSF13B, TNF
5go 697646 6210.9TNF, HSPG2, MMP2
6ctla4-ig469.9CD80, CD28
7heparan sulfate46 2510.8CD4, TIMP3, HSPG2, TNC
8blys469.7TNF, TNFSF13B
9rituximab46 52 1211.7CD80, TNF, TNFSF13B
10n-formylmethionyl-leucylphenylalanine469.7TNF, HSPG2, ITGAL
11nickel46 2510.7HLA-DQB1, ITGAL, CD4
12glycosaminoglycan469.6TIMP3, OSM, TNC
13efalizumab46 1210.6ITGAL, TNF
14propranolol46 30 52 25 1213.5ITGAL, HTR3A, MMP2, HSPG2
15chloroquine46 3 52 30 1213.5TNF, ITGAL, CD4
16matrigel469.4MMP2, TIMP3, OSM, TNC
17phorbol469.4CD4, ITGAL, MMP2, TNC
18histamine46 30 2511.4HTR3A, OSM, HSPG2, TNF
19azathioprine46 3 52 1212.3ITGAL, MMP2, OSM
20phosphoinositide469.3TNC, HSPG2, ITGAL, CD28
21prednisolone46 30 1211.2ITGAL, MMP2, TNF
22heparin46 30 25 1212.2CD4, ITGAL, TIMP3, HSPG2, TNC
23oligonucleotide469.2HLA-DQB1, TNC, TIMP3, CD4, CD28
24hyaluronic acid46 2510.2TNC, OSM, MMP2, ITGAL
25pd 98,059469.2TNF, HSPG2, OSM, TIMP3, MMP2
26tgf beta1469.1TNC, TNF, OSM, TIMP3, MMP2
27ionomycin469.1CD80, CD28, ITGAL, TNF
28fibrinogen469.1TNC, TNF, OSM, ITGAL
29h2o2469.1TNC, TNF, HSPG2, MMP2, ITGAL
30ly294002469.0TNC, TNF, HSPG2, TIMP3, MMP2, CD28
31vegf468.9TNC, TNF, HSPG2, OSM, TIMP3, MMP2
32cyclosporin a46 30 6210.8CD80, CD28, ITGAL, TNF
33proline468.8MMP2, ITGAL, CD4, CD28, CD80
34herbimycin a46 629.7TNF, HSPG2, OSM, MMP2, CD4, CD28
35alanine468.7TNFSF13B, HSPG2, OSM, MMP2, ITGAL, CD4
36glutamate468.7HLA-DQB1, TNC, HSPG2, TIMP3, MMP2, ITGAL
37rantes468.5TNF, OSM, CCL23, ITGAL, CD4
38genistein46 30 62 3 25 1213.5TNF, HSPG2, OSM, TIMP3, MMP2, CD4
39wortmannin468.4TNC, HSPG2, TIMP3, MMP2, ITGAL, CD28
40retinoic acid46 259.4TNC, TNF, HSPG2, OSM, TIMP3, MMP2
41cysteine468.2TNC, OSM, TIMP3, MMP2, ITGAL, CD4
42lipid468.2TNC, TNF, OSM, TIMP3, ITGAL, CD4
43oxygen46 259.2TNF, TIMP3, ITGAL, CD28, CD80
44pge2468.1TNF, HSPG2, OSM, MMP2, ITGAL, CD4
45serine467.9TNC, TNF, HSPG2, OSM, MMP2, ITGAL
46cycloheximide467.9TNC, TNF, HSPG2, OSM, MMP2, ITGAL
47dexamethasone46 52 30 1210.6CD80, TNC, TNF, HSPG2, OSM, TIMP3
48phosphatidylinositol467.6TNC, HSPG2, OSM, TIMP3, MMP2, ITGAL
49tyrosine467.3HLA-DQB1, TNC, HSPG2, OSM, TIMP3, MMP2
50calcium46 52 25 129.7TNC, TNFSF13B, HSPG2, OSM, TIMP3, MMP2

GO Terms for genes affiliated with Sialadenitis

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17Gene Ontology
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Cellular components related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.7TIMP3, HSPG2, TNC
2external side of plasma membraneGO:0098978.1TNF, ITGAL, CD4, CD28, CD80
3extracellular spaceGO:0056157.0CCL23, EBI3, TNC, TNFSF13B, TNF, HSPG2
4plasma membraneGO:0058866.1EBI3, HLA-DQB1, TNFSF13B, TNF, HSPG2, MMP2

Biological processes related to Sialadenitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of defense response to virus by virusGO:0506909.7CD28, CD4
2positive regulation of calcium-mediated signalingGO:0508509.5CD4, ITGAL
3positive regulation of interleukin-2 biosynthetic processGO:0450869.5CD4, CD28, CD80
4positive regulation of T cell proliferationGO:0421029.4CD28, ITGAL, TNFSF13B
5positive regulation of mitosisGO:0458409.4CD28, TNF
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2OSM, CD4, CD80
7positive regulation of alpha-beta T cell proliferationGO:0466419.0CD80, CD28, EBI3
8T cell costimulationGO:0312959.0CD80, CD28, CD4, TNFSF13B, HLA-DQB1
9humoral immune responseGO:0069598.9CD28, TNF, EBI3
10extracellular matrix organizationGO:0301988.9ITGAL, MMP2, HSPG2, TNF, TNC
11immune responseGO:0069558.6HLA-DQB1, TNFSF13B, OSM, CCL23, CD4

Molecular functions related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.8TNF, TNFSF13B
2coreceptor activityGO:0150269.3CD80, CD28, CD4
3cytokine activityGO:0051258.4EBI3, TNFSF13B, TNF, OSM
4protein bindingGO:0055156.2EBI3, TNFSF13B, TNF, HSPG2, TIMP3, MMP2

Products for genes affiliated with Sialadenitis

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  • Antibodies
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Sources for Sialadenitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet