MCID: SLD003
MIFTS: 59

Sialadenitis malady

Rare diseases, Gastrointestinal diseases, Oral diseases, Endocrine diseases categories

Summaries for Sialadenitis

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NIH Rare Diseases:42 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/17/2014

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to b-cell lymphomas and arthritis. An important gene associated with Sialadenitis is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Cytokines and Inflammatory Response and IL12 signaling mediated by STAT4. The compounds cicaprost and abatacept have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and b cells, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:64 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Aliases & Classifications for Sialadenitis

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Sialadenitis, Aliases & Descriptions:

Name: Sialadenitis 9 42 11 44 61
Sialoadenitis 9 42 61
Salivary Gland Inflammation 42 61
 
Adenitis, Salivary Gland 42
Sialoadenitis Nos 9


Classifications:



External Ids:

Disease Ontology9 DOID:10303
ICD9CM28 527.2
MeSH34 D012793
NCIt39 C26882
ICD1026 K11.2

Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas30.8TNFSF13B, ITGAL, CD80
2arthritis30.7TNF, OSM
3hepatitis c30.6HSPG2, TIMP3, CD4, CD28
4hodgkin's lymphoma30.5CD80, CD28, TNFSF13B, EBI3
5sjogren's syndrome30.3TNFSF13B, HSPG2, ITGAL, CD28, CD80
6vasculitis30.1TNFSF13B, TNF, CD80
7connective tissue disease30.1CD4, TNF
8t-cell leukemia30.0ITGAL, CD4, CD28
9adenoma29.9TNC, HSPG2, OSM, TIMP3
10tuberculosis29.6HLA-DQB1, TNF, ITGAL, CD4
11sarcoidosis29.5HLA-DQB1, TNF, CD4, CD28, CD80
12osteoarthritis29.4CD80, MMP2, TIMP3, OSM, TNF
13leukemia29.3TNF, OSM, HTR3A, ITGAL, CD4, CD80
14rheumatoid arthritis28.3HLA-DQB1, CD80, CD28, TNFSF13B, TNF, HSPG2
15xanthogranulomatous sialadenitis10.4
16nodular goiter10.4CD28, CD80
17extrinsic allergic alveolitis10.4ITGAL, CD28
18mast cell neoplasm10.4ITGAL, CD80
19mycobacterium avium complex disease10.4CD4
20listeriosis10.4CD4
21central nervous system lymphoma10.4CD4
22cryptococcosis10.4CD4
23histoplasmosis10.4CD4
24polymyositis10.4CD80, CD28, HSPG2
25common variable immunodeficiency10.3TNFSF13B, CD28
26hepatitis10.3
27sialolithiasis10.3
28dacryoadenitis10.3
29spondylarthropathy10.3TNF, ITGAL
30myocarditis10.3CD4
31chronic lymphocytic leukemia10.3TNFSF13B, ITGAL, CD80
32leishmaniasis10.3CD4
33arthropathy10.3OSM, TNF
34leprosy10.3CD4
35mumps10.3
36thyroiditis10.3
37retroperitoneal fibrosis10.3
38graft versus host disease10.2CD28, ITGAL, TNF
39pulmonary sarcoidosis10.2CD80, ITGAL, TNF
40pancreatitis10.2
41hepatitis c virus10.2
42non-hodgkin lymphoma10.2TNFSF13B, ITGAL, CD28, CD80
43thyroid hurthle cell carcinoma10.2TIMP3, HSPG2, TNC
44bullous pemphigoid10.2HLA-DQB1, TNFSF13B, ITGAL
45tetanus10.2CD80, CD28, CD4
46myelitis10.2
47keratoconjunctivitis sicca10.2
48keratoconjunctivitis10.2
49chagas disease10.2CD4, CD28
50acute myocardial infarction10.2TNC, HTR3A, ITGAL

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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Drugs & Therapeutics for Sialadenitis

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Drug clinical trials:

Search ClinicalTrials for Sialadenitis

Search NIH Clinical Center for Sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

32
Salivary gland, T cells, B cells, Thyroid, Lymph node, Liver, Thymus, Lung, Endothelial, Tongue

Animal Models for Sialadenitis or affiliated genes

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Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Chronic sialadenitis with marked lymphadenopathy mimicking lymphoma on FDG PET/CT. (24978334)
2014
2
Imaging in acute obstructive sialadenitis. (24712336)
2014
3
The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease. (24593171)
2014
4
Salivary endoscopy for idiopathic chronic sialadenitis. (23712592)
2013
5
Prediction of risk for symptomatic sialadenitis by post-therapeutic dual (131)I scintigraphy in patients with differentiated thyroid cancer. (23921836)
2013
6
Superficial parotidectomy for chronic parotid sialadenitis. (22560869)
2013
7
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
8
Pediatric chronic sclerosing sialadenitis: KA1ttner tumor. (21985393)
2012
9
Tenascin-C in chronic sclerosing sialadenitis. (21559807)
2011
10
Sialoendoscopy in the diagnosis and management of obstructive sialadenitis. (21298637)
2011
11
Chronic Sclerosing Sialadenitis (KA1ttner's tumour) of the Parotid Gland. (22135562)
2010
12
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
13
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
14
Pathology quiz case 2. Chronic sclerosing sialadenitis (CSS). (19289717)
2009
15
Concurrent sialocoele and necrotising sialadenitis in a dog. (19261087)
2009
16
Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in SjAPgren's syndrome-associated autoimmune sialadenitis. (19716548)
2009
17
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
18
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
19
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
20
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. (17900348)
2007
21
Surgical treatment of chronic parotid sialadenitis. (17166325)
2007
22
Sialadenitis of the left submandibular gland/sialolith. (16163878)
2005
23
Chronic sclerosing sialadenitis of the parotid gland: diagnosis using color Doppler sonography and sonographically guided needle biopsy. (15784774)
2005
24
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
25
Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice. (15763917)
2004
26
Acute ischemic sialadenitis following facial artery embolization. (15129338)
2004
27
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
28
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
29
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
30
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
31
Subacute necrotizing sialadenitis in the buccal mucosa. (12465016)
2002
32
Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS). (11693172)
2001
33
Relation of preoperative sialographic findings with histopathological diagnosis in cases of obstructive sialadenitis of the parotid and submandibular glands: retrospective study. (10475651)
1999
34
Lymphoma presenting as parotid xanthogranulomatous sialadenitis. (9881792)
1998
35
Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. (9409649)
1997
36
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
37
On focal lymphocytic sialadenitis as a gold standard for the diagnosis of SjAPgren's syndrome: comment on the article by Daniels and Whitcher. (7779134)
1995
38
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
39
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
40
Lymphocytic sialadenitis of SjAPgren's syndrome associated with chronic hepatitis C virus liver disease. (1346409)
1992
41
Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction. (2036674)
1991
42
Radionuclide imaging of potassium iodide-induced sialadenitis. (3034466)
1987
43
Bilateral obstructive sialadenitis of the submandibular glands due to a denture. (3474000)
1987
44
Sialadenitis in children. (3744701)
1986
45
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
46
Oxyphenbutazone-induced sialadenitis, intrahepatic cholestasis and pancreatitis. (3832725)
1985
47
Contrast induced sialadenitis--a case report. (6544850)
1984
48
Diagnosis please. Benign follicular hyperplasia of a submandibular lymph node and chronic sialadenitis. (4516846)
1973
49
SODIUM IODIDE-INDUCED SUBMAXILLARY SIALADENITIS IN THE RAT. (14101183)
1963
50
Chronic sialadenitis and sialography. (14370773)
1955

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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Expression patterns in normal tissues for genes affiliated with Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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Pathways related to Sialadenitis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CD4, TNF
29.7CD28, CD4
3
Show member pathways
9.7CD28, CD4
49.6CD28, CD80
59.6CD28, CD80
6
Show member pathways
9.6CD28, CD80
7
Show member pathways
9.6TIMP3, TNF, TNFSF13B
89.6MMP2, TIMP3, TNC
9
Show member pathways
9.6TNC, TIMP3, MMP2
10
Show member pathways
9.5TNF, TNFSF13B, HLA-DQB1
11
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
9.4CD28, CD4, HLA-DQB1
129.4ITGAL, HSPG2, TNC
13
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.4CD4, MMP2, TNF
14
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.4CD80, HSPG2, TNF
15
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.4TNF, CD4, CD28
16
Show member pathways
9.3CD4, CD28, CD80
17
Show member pathways
TCR signaling in naive CD8+ T cells37
9.3CD80, CD28, CD4
18
Show member pathways
9.3TNF, HSPG2, TIMP3, MMP2
199.3TNF, HSPG2, TIMP3, MMP2
20
Show member pathways
9.3EBI3, TNF
21
Show member pathways
9.2TNC, HSPG2, TIMP3, ITGAL
22
Show member pathways
9.1TNC, HSPG2, MMP2, ITGAL
23
Show member pathways
9.0ITGAL, MMP2, TIMP3, TNF
24
Show member pathways
9.0HLA-DQB1, CD4, CD28, CD80
25
Show member pathways
Immune response T cell receptor signaling pathway59
Immune response CD28 signaling59
Immune response ICOS pathway in T helper cell59
9.0HLA-DQB1, CD4, CD28, CD80
26
Show member pathways
9.0CD80, CD28, CD4, HLA-DQB1
27
Show member pathways
9.0CD80, CD28, CD4, HLA-DQB1
28
Show member pathways
8.7CD80, CD28, HSPG2, TNF, HLA-DQB1
29
Show member pathways
8.5TNC, HSPG2, MMP2, CCL23, ITGAL
30
Show member pathways
8.5HLA-DQB1, ITGAL, CD4, CD28, CD80
318.5HLA-DQB1, ITGAL, CD4, CD28, CD80
328.2HLA-DQB1, TNFSF13B, TNF, ITGAL, CD28, CD80
33
Show member pathways
IL27-mediated signaling events37
8.1EBI3, TNF, CD4, CD28, CD80
34
Show member pathways
7.9HLA-DQB1, TIMP3, MMP2, ITGAL, CD4, CD28
35
Show member pathways
7.8HLA-DQB1, TNFSF13B, TNF, ITGAL, CD4, CD28
36
Show member pathways
7.7TNFSF13B, TNF, TIMP3, CCL23, ITGAL, CD4
37
Show member pathways
7.5TNFSF13B, TNF, OSM, CCL23, CD4, CD28
38
Show member pathways
7.3TNFSF13B, TNF, OSM, TIMP3, CCL23, CD4
39
Show member pathways
6.8TNFSF13B, TNF, OSM, TIMP3, CCL23, ITGAL
40
Show member pathways
6.2CD80, TNC, TNFSF13B, TNF, HSPG2, OSM

Compounds for genes affiliated with Sialadenitis

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Compounds related to Sialadenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1cicaprost44 2911.0TNF, HSPG2
2abatacept44 1211.0CD80, TNF
3cilomilast4410.0MMP2, TNF
4bcma449.9TNFSF13B, TNF
5go 697644 6010.9TNF, HSPG2, MMP2
6ctla4-ig449.9CD80, CD28
7heparan sulfate44 2510.8CD4, TIMP3, HSPG2, TNC
8blys449.7TNF, TNFSF13B
9rituximab44 50 1211.7CD80, TNF, TNFSF13B
10n-formylmethionyl-leucylphenylalanine449.7TNF, HSPG2, ITGAL
11nickel44 2510.7HLA-DQB1, ITGAL, CD4
12glycosaminoglycan449.6TIMP3, OSM, TNC
13efalizumab44 1210.6ITGAL, TNF
14propranolol44 29 50 25 1213.5ITGAL, HTR3A, MMP2, HSPG2
15chloroquine44 3 50 29 1213.5TNF, ITGAL, CD4
16matrigel449.4MMP2, TIMP3, OSM, TNC
17phorbol449.4CD4, ITGAL, MMP2, TNC
18histamine44 29 2511.4HTR3A, OSM, HSPG2, TNF
19azathioprine44 3 50 1212.3ITGAL, MMP2, OSM
20phosphoinositide449.3TNC, HSPG2, ITGAL, CD28
21prednisolone44 29 1211.2ITGAL, MMP2, TNF
22heparin44 29 25 1212.2CD4, ITGAL, TIMP3, HSPG2, TNC
23oligonucleotide449.2HLA-DQB1, TNC, TIMP3, CD4, CD28
24hyaluronic acid44 2510.2TNC, OSM, MMP2, ITGAL
25pd 98,059449.2TNF, HSPG2, OSM, TIMP3, MMP2
26tgf beta1449.1TNC, TNF, OSM, TIMP3, MMP2
27ionomycin449.1CD80, CD28, ITGAL, TNF
28fibrinogen449.1TNC, TNF, OSM, ITGAL
29h2o2449.1TNC, TNF, HSPG2, MMP2, ITGAL
30ly294002449.0TNC, TNF, HSPG2, TIMP3, MMP2, CD28
31vegf448.9TNC, TNF, HSPG2, OSM, TIMP3, MMP2
32cyclosporin a44 29 6010.8CD80, CD28, ITGAL, TNF
33proline448.8MMP2, ITGAL, CD4, CD28, CD80
34herbimycin a44 609.7TNF, HSPG2, OSM, MMP2, CD4, CD28
35alanine448.7TNFSF13B, HSPG2, OSM, MMP2, ITGAL, CD4
36glutamate448.7HLA-DQB1, TNC, HSPG2, TIMP3, MMP2, ITGAL
37rantes448.5TNF, OSM, CCL23, ITGAL, CD4
38genistein44 29 60 3 25 1213.5TNF, HSPG2, OSM, TIMP3, MMP2, CD4
39wortmannin448.4TNC, HSPG2, TIMP3, MMP2, ITGAL, CD28
40retinoic acid44 259.4TNC, TNF, HSPG2, OSM, TIMP3, MMP2
41cysteine448.2TNC, OSM, TIMP3, MMP2, ITGAL, CD4
42lipid448.2TNC, TNF, OSM, TIMP3, ITGAL, CD4
43oxygen44 259.2TNF, TIMP3, ITGAL, CD28, CD80
44pge2448.1TNF, HSPG2, OSM, MMP2, ITGAL, CD4
45serine447.9TNC, TNF, HSPG2, OSM, MMP2, ITGAL
46cycloheximide447.9TNC, TNF, HSPG2, OSM, MMP2, ITGAL
47dexamethasone44 50 29 1210.6CD80, TNC, TNF, HSPG2, OSM, TIMP3
48phosphatidylinositol447.6TNC, HSPG2, OSM, TIMP3, MMP2, ITGAL
49tyrosine447.3HLA-DQB1, TNC, HSPG2, OSM, TIMP3, MMP2
50calcium44 50 25 129.7TNC, TNFSF13B, HSPG2, OSM, TIMP3, MMP2

GO Terms for genes affiliated with Sialadenitis

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Cellular components related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.7TIMP3, HSPG2, TNC
2external side of plasma membraneGO:0098978.1TNF, ITGAL, CD4, CD28, CD80
3extracellular spaceGO:0056157.0CCL23, EBI3, TNC, TNFSF13B, TNF, HSPG2
4plasma membraneGO:0058866.1EBI3, HLA-DQB1, TNFSF13B, TNF, HSPG2, MMP2

Biological processes related to Sialadenitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of defense response to virus by virusGO:0506909.7CD28, CD4
2positive regulation of calcium-mediated signalingGO:0508509.5CD4, ITGAL
3positive regulation of interleukin-2 biosynthetic processGO:0450869.5CD4, CD28, CD80
4positive regulation of T cell proliferationGO:0421029.4CD28, ITGAL, TNFSF13B
5positive regulation of mitosisGO:0458409.4CD28, TNF
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2OSM, CD4, CD80
7positive regulation of alpha-beta T cell proliferationGO:0466419.0CD80, CD28, EBI3
8T cell costimulationGO:0312959.0CD80, CD28, CD4, TNFSF13B, HLA-DQB1
9humoral immune responseGO:0069598.9CD28, TNF, EBI3
10extracellular matrix organizationGO:0301988.9ITGAL, MMP2, HSPG2, TNF, TNC
11immune responseGO:0069558.6HLA-DQB1, TNFSF13B, OSM, CCL23, CD4

Molecular functions related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.8TNF, TNFSF13B
2coreceptor activityGO:0150269.3CD80, CD28, CD4
3cytokine activityGO:0051258.4EBI3, TNFSF13B, TNF, OSM
4protein bindingGO:0055156.2EBI3, TNFSF13B, TNF, HSPG2, TIMP3, MMP2

Products for genes affiliated with Sialadenitis

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Sources for Sialadenitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet