MCID: SLD003
MIFTS: 42

Sialadenitis malady

Rare diseases, Gastrointestinal diseases, Oral diseases, Endocrine diseases categories

Aliases & Classifications for Sialadenitis

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Aliases & Descriptions for Sialadenitis:

Name: Sialadenitis 10 45 47 12 65 36
Sialoadenitis 10 45
 
Salivary Gland Inflammation 45
Adenitis, Salivary Gland 45


Classifications:



External Ids:

Disease Ontology10 DOID:10303
NCIt42 C26882
ICD9CM29 527.2
MeSH36 D012793
ICD1027 K11.2

Summaries for Sialadenitis

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NIH Rare Diseases:45 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/17/2014

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to xanthogranulomatous sialadenitis and dacryoadenitis. An important gene associated with Sialadenitis is TNFSF13B (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b), and among its related pathways are Cytokines and Inflammatory Response and Rheumatoid arthritis. Affiliated tissues include salivary gland, t cells and b cells, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Wikipedia:68 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1xanthogranulomatous sialadenitis10.5
2dacryoadenitis10.4
3hepatitis10.4
4hepatitis c10.4
5sialolithiasis10.4
6b-cell lymphomas10.3
7pancreatitis10.3
8arthritis10.3
9mumps10.3
10retroperitoneal fibrosis10.3
11best1 retinopathy10.3HLA-DQB1, TNF
12microsomia hemifacial radial defects10.3HLA-DQB1, TNF
13intermediate anorectal malformation10.3HLA-DQB1, TNF
14hepatitis c virus10.3
15thyroiditis10.3
16microsporidiosis10.2HLA-DQB1, TNF
17moderately severe hemophilia a10.2HLA-DQB1, TNF
18cytoplasmic body myopathy10.2HLA-DQB1, TNF
19limb deficiencies distal with micrognathia10.2MMP2, TNC
20subacute leukemia10.2MMP2, TNC
21anal spasm10.2HTR3A, TNC
22rheumatoid arthritis10.2
23obesity10.2
24cholangitis10.2
25endophthalmitis10.2HLA-DQB1, TNF
26neurofibromatosis, type 210.2MMP2, TIMP3
27keratoconjunctivitis sicca10.2
28myelitis10.2
29keratoconjunctivitis10.2
30mikulicz disease10.2
31papillary adenocarcinoma10.2HLA-DQB1, TNF
32hemifacial spasm10.2HLA-DQB1, HTR3A, TNF
33hypersensitivity reaction type iii disease10.1HLA-DQB1, TNF, TNFSF13B
34cerebral sarcoidosis10.1HLA-DQB1, TNC, TNF
35glycogen storage disease viii10.1CD4, TNF
36neurotic excoriation10.1CD4, TNF
37mononeuritis of lower limb10.1CDSN, HSPG2
38conjunctival deposit10.1CDSN, HSPG2
39congenital ichthyosiform erythroderma10.1CDSN, HSPG2
40fibroepithelial polyp of the anus10.1CD4, TNF
41central neurocytoma10.1CD4, TNF
42benign lymphoepithelial lesion of salivary gland10.1CD4, TNF
43mood disorder10.1CDSN, HSPG2
44discrete subaortic stenosis10.1CD4, TNF
45prion disease10.1CD4, TNF
46glomerulonephritis10.1
47anhidrosis10.1
48sjogren's syndrome10.1
49parotitis10.1
50acquired immunodeficiency syndrome10.1

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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Drugs & Therapeutics for Sialadenitis

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Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 1, Phase 21514174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dental Safety Profile of High-Dose Radioiodine TherapyCompletedNCT00439478Phase 4
2Rituximab in IgG4-related Disease: A Phase 1-2 TrialCompletedNCT01584388Phase 1, Phase 2
3The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid CancerRecruitingNCT01833650
4Cohort Study of IgG4RDRecruitingNCT01670695Phase 0

Search NIH Clinical Center for Sialadenitis


Cochrane evidence based reviews: Sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

33
Salivary gland, T cells, B cells, Thyroid, Lymph node, Liver, Tongue

Animal Models for Sialadenitis or affiliated genes

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MGI Mouse Phenotypes related to Sialadenitis:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.0HLA-DQB1, HSPG2, RAG1, TIMP3, TNF
2MP:00053817.9AQP5, CD4, HLA-DQB1, HSPG2, RAG1, TNF
3MP:00053917.9AQP5, HSPG2, MMP2, RAG1, TIMP3, TNF
4MP:00053857.9CDSN, HLA-DQB1, HSPG2, MMP2, RAG1, TIMP3
5MP:00053697.8AQP5, HLA-DQB1, HSPG2, HTR3A, MMP2, TIMP3
6MP:00107717.7CD4, CDSN, HSPG2, HTR3A, RAG1, TIMP3
7MP:00053887.5AQP5, HLA-DQB1, HSPG2, MMP2, RAG1, TIMP3
8MP:00036317.3CD4, HLA-DQB1, HSPG2, HTR3A, MMP2, RAG1
9MP:00053867.2AQP5, HLA-DQB1, HSPG2, HTR3A, RAG1, TIMP3
10MP:00053797.2AQP5, CDSN, HLA-DQB1, HTR3A, RAG1, TIMP3
11MP:00053976.6CD4, HLA-DQB1, HSPG2, HTR3A, MMP2, RAG1
12MP:00053876.3CD4, CDSN, HLA-DQB1, HSPG2, HTR3A, MMP2
13MP:00107686.1AQP5, CD4, CDSN, HLA-DQB1, HSPG2, HTR3A
14MP:00053786.1AQP5, CD4, CDSN, HLA-DQB1, HSPG2, HTR3A
15MP:00053765.5AQP5, CD4, CDSN, HLA-DQB1, HSPG2, HTR3A

Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50)    (show all 418)
idTitleAuthorsYear
1
Clinicopathological characteristics of immunoglobulin G4-related sialadenitis. (26194097)
2015
2
Chronic Sclerosing Sialadenitis of the Submandibular Gland as the Initial Symptom of IgG4-Related Disease: A Case Report. (26084640)
2015
3
Sialendoscopy in sialadenitis: an unselected cohort of 228 patients. (26333199)
2015
4
Chronic sialadenitis with marked lymphadenopathy mimicking lymphoma on FDG PET/CT. (24978334)
2014
5
Clinical and quality-of-life outcomes following gland-preserving surgery for chronic sialadenitis. (25424183)
2014
6
Imaging in acute obstructive sialadenitis. (24712336)
2014
7
The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease. (24593171)
2014
8
Salivary endoscopy for idiopathic chronic sialadenitis. (23712592)
2013
9
Prediction of risk for symptomatic sialadenitis by post-therapeutic dual (131)I scintigraphy in patients with differentiated thyroid cancer. (23921836)
2013
10
Superficial parotidectomy for chronic parotid sialadenitis. (22560869)
2013
11
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
12
Tenascin-C in chronic sclerosing sialadenitis. (21559807)
2011
13
Sialoendoscopy in the diagnosis and management of obstructive sialadenitis. (21298637)
2011
14
Chronic Sclerosing Sialadenitis (KA1ttner's tumour) of the Parotid Gland. (22135562)
2010
15
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
16
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
17
Pathology quiz case 2. Chronic sclerosing sialadenitis (CSS). (19289717)
2009
18
Concurrent sialocoele and necrotising sialadenitis in a dog. (19261087)
2009
19
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
20
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
21
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
22
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. (17900348)
2007
23
Surgical treatment of chronic parotid sialadenitis. (17166325)
2007
24
Sialadenitis of the left submandibular gland/sialolith. (16163878)
2005
25
Chronic sclerosing sialadenitis of the parotid gland: diagnosis using color Doppler sonography and sonographically guided needle biopsy. (15784774)
2005
26
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
27
Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice. (15763917)
2004
28
Acute ischemic sialadenitis following facial artery embolization. (15129338)
2004
29
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
30
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
31
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
32
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
33
Subacute necrotizing sialadenitis in the buccal mucosa. (12465016)
2002
34
Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS). (11693172)
2001
35
Relation of preoperative sialographic findings with histopathological diagnosis in cases of obstructive sialadenitis of the parotid and submandibular glands: retrospective study. (10475651)
1999
36
Lymphoma presenting as parotid xanthogranulomatous sialadenitis. (9881792)
1998
37
Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. (9409649)
1997
38
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
39
On focal lymphocytic sialadenitis as a gold standard for the diagnosis of SjAPgren's syndrome: comment on the article by Daniels and Whitcher. (7779134)
1995
40
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
41
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
42
Lymphocytic sialadenitis of SjAPgren's syndrome associated with chronic hepatitis C virus liver disease. (1346409)
1992
43
Radionuclide imaging of potassium iodide-induced sialadenitis. (3034466)
1987
44
Bilateral obstructive sialadenitis of the submandibular glands due to a denture. (3474000)
1987
45
Sialadenitis in children. (3744701)
1986
46
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
47
Contrast induced sialadenitis--a case report. (6544850)
1984
48
Diagnosis please. Benign follicular hyperplasia of a submandibular lymph node and chronic sialadenitis. (4516846)
1973
49
SODIUM IODIDE-INDUCED SUBMAXILLARY SIALADENITIS IN THE RAT. (14101183)
1963
50
Chronic sialadenitis and sialography. (14370773)
1955

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD4, TNF
29.6HLA-DQB1, TNF, TNFSF13B
39.3CD4, RAG1
4
Angiogenesis (CST)
Show member pathways
9.3CD4, RAG1
59.0HSPG2, MMP2, TIMP3, TNF
6
Show member pathways
9.0HSPG2, MMP2, TIMP3, TNF
78.8CD4, RAG1, TNF, TNFSF13B

GO Terms for genes affiliated with Sialadenitis

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Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00056049.3HSPG2, TIMP3, TNC
2extracellular matrixGO:00310128.7HSPG2, MMP2, TIMP3, TNC
3extracellular spaceGO:00056158.4HSPG2, MMP2, TIMP3, TNC, TNF, TNFSF13B

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:00312959.7CD4, HLA-DQB1, TNFSF13B
2extracellular matrix organizationGO:00301989.1HSPG2, MMP2, TNC, TNF
3immune responseGO:00069558.6CD4, HLA-DQB1, RAG1, TNF, TNFSF13B

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.9TNF, TNFSF13B

Sources for Sialadenitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet