MCID: SLD003
MIFTS: 53

Sialadenitis malady

Gastrointestinal diseases, Endocrine diseases categories

Summaries for Sialadenitis

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/4/2010

MalaCards: Sialadenitis, also known as sialoadenitis, is related to hepatitis and hepatitis c. An important gene associated with Sialadenitis is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Immune response NFAT in immune response and Immune response ICOS pathway in T-helper cell. The compounds cycloheximide and thymoglobulin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, b cells and t cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Wikipedia:63 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Aliases & Classifications for Sialadenitis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Endocrine diseases


Aliases & Descriptions:

sialadenitis 8 42 10 44 60
sialoadenitis 8 42
salivary gland inflammation 42
adenitis, salivary gland 42
sialoadenitis nos 8


External Ids:

Disease Ontology8 DOID:10303
MeSH34 D012793
NCIt39 C26882
ICD9CM27 527.2
ICD1025 K11.2

Related Diseases for Sialadenitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.4HSPG2
2hepatitis c30.4TIMP3, CALR, TNFSF13B, CD28, PTPRC
3arthritis30.3TIMP3, OSM, CD80
4pancreatitis30.2HSPG2
5hepatitis b30.2HLA-DQB1, ITGAL, CD80
6autoimmune hepatitis30.1HSPG2, HLA-DQB1, PTPRC
7glomerulonephritis30.1CD28, ITGAL
8hodgkin's lymphoma30.1TNFSF13B, EBI3, CD80, CD28, PTPRC
9rheumatoid arthritis30.1TNFSF13B, CALR, TIMP3, HSPG2, OSM, HLA-DQB1
10thyroid cancer30.0TNC, TIMP3, HSPG2
11sjogren's syndrome29.9HSPG2, CALR, TNFSF13B, ITGAL, SSB, TROVE2
12purpura29.9HSPG2
13connective tissue disease29.8TROVE2
14lupus erythematosus29.7CALR, TROVE2
15vasculitis29.7TNFSF13B, CD80
16osteoarthritis29.7CD80, OSM, TIMP3
17primary biliary cirrhosis29.7HSPG2, CALR, ITGAL
18sarcoidosis29.7HLA-DQB1, CD80, CD28, PTPRC
19leukemia29.7HTR3A, OSM, ITGAL, CD80, PTPRC
20tuberculosis29.7CALR, HLA-DQB1, ITGAL, PTPRC
21sialolithiasis10.3
22xanthogranulomatous sialadenitis10.2
23dacryoadenitis10.2
24thyroiditis10.2
25mumps10.2
26myelitis10.1
27keratoconjunctivitis sicca10.1
28keratoconjunctivitis10.1
29cholangitis10.1
30obesity10.1
31salivary gland disease10.1
32mikulicz disease10.1
33anhidrosis10.0
34chronic dacryoadenitis10.0
35acquired immunodeficiency syndrome10.0
36sclerosing cholangitis10.0
37hepatitis a10.0
38hypertension10.0
39systemic lupus erythematosus10.0TNFSF13B
40dry eye syndrome10.0HSPG2
41diabetic retinopathy10.0TIMP3
42proliferative diabetic retinopathy10.0TIMP3
43malt lymphoma10.0CD80
44dementia10.0HTR3A
45wegener's granulomatosis10.0CD80, CD28
46stomach cancer10.0CD80, TIMP3
47polymyositis10.0CD28, CD80, HSPG2
48dermatomyositis10.0CD28, TROVE2, HSPG2
49osteosarcoma10.0HSPG2, OSM
50severe combined immunodeficiency10.0PTPRC

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Clinical Features for Sialadenitis

About this section

Drugs & Therapeutics for Sialadenitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sialadenitis

Drug clinical trials:

Search ClinicalTrials for Sialadenitis

Search NIH Clinical Center for Sialadenitis

Search CenterWatch for Sialadenitis

Genetic Tests for Sialadenitis

About this section

Anatomical Context for Sialadenitis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Sialadenitis:

32
Salivary gland, B cells, T cells, Thyroid, Lymph node, Liver, Lung, Thymus, Endothelial, Tongue

Animal Models for Sialadenitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Sialadenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1HTR3A, HLA-DQB1, TROVE2, EBI3, PTPRC, TIMP3
2MP:00053978.2HTR3A, TNFSF13B, TIMP3, HSPG2, HLA-DQB1, ITGAL
3MP:00053878.1PTPRC, HSPG2, TIMP3, TNFSF13B, HTR3A, HLA-DQB1
4MP:00053847.9TNFSF13B, CALR, TIMP3, HSPG2, HLA-DQB1, ITGAL
5MP:00036317.9HSPG2, CALR, TNC, HTR3A, OSM, HLA-DQB1
6MP:00053767.9TNC, CALR, TIMP3, HSPG2, HTR3A, HLA-DQB1

Publications for Sialadenitis

About this section
Sources:
50PubMed
See all sources

Articles related to Sialadenitis:

(show top 50)    (show all 373)
idTitleAuthorsYear
1
Sialoendoscopy with and without holmium:YAG laser-assisted lithotripsy in the management of obstructive sialadenitis of major salivary glands. (24280118)
2014
2
Salivary endoscopy in a pediatric patient with HLA-B27 seropositivity and recurrent submandibular sialadenitis. (23639340)
2013
3
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
4
Imaging findings of "anesthesia mumps" (acute postoperative sialadenitis) after general anesthesia. (23192214)
2012
5
Iodide mumps: a case report of complicated radioactive iodine causing sialadenitis. (21354757)
2012
6
Facial vein aneurysm associated with sialadenitis. (22253006)
2012
7
Autoimmune dacryoadenitis and sialadenitis induced in rabbits by intravenous injection of autologous lymphocytes activated ex vivo against lacrimal antigens. (22333667)
2012
8
Tenascin-C in chronic sclerosing sialadenitis. (21559807)
2011
9
Chronic sclerosing sialadenitis as one of the immunoglobulin G4-related diseases: a clinicopathological study of six cases from Central Europe. (21438912)
2011
10
Neoplasm mimics of rheumatologic presentations: sialadenitis, ocular masquerade syndromes, retroperitoneal fibrosis, and regional pain syndromes. (22075201)
2011
11
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
12
Immunoprofile of KA1ttner tumor (chronic sclerosing sialadenitis). (20667925)
2010
13
Lichen planus sialadenitis: a mucosal analog of lichen planopilaris and lichen planoporitis. (19656167)
2010
14
Neonatal suppurative submandibular sialadenitis. (19480333)
2009
15
Obstructive sialadenitis of submandibular gland due to foreign body successfully treated by sialoendoscopic intervention. (19446229)
2009
16
Immunoglobulin G4-related sclerosing sialadenitis: report of two cases and review of the literature. (19778741)
2009
17
Fibroblasts in chronic submandibular sialadenitis. (19076551)
2008
18
Oral diseases associated with hepatitis C virus infection. Part 1. sialadenitis and salivary glands lymphoma. (18208477)
2008
19
Chronic sclerosing sialadenitis mimicking tumors of the salivary glands. (17382510)
2007
20
Sialadenitis following radioiodine therapy - a new diagnostic and treatment modality. (16910918)
2006
21
Solitary extramedullary plasmacytoma and granulomatous sialadenitis of the parotid gland preceding a B-cell non-Hodgkin's lymphoma. (16489463)
2006
22
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
23
Lymphocyte subsets in irradiation-induced sialadenitis of the submandibular gland. (16241997)
2005
24
Chronic Sialadenitis revealing hepatitis C: a case report. (15292872)
2004
25
Vascular endothelial cell participation in formation of lymphoepithelial lesions (epi-myoepithelial islands) in lymphoepithelial sialadenitis (benign lymphoepithelial lesion). (12761623)
2003
26
Subacute necrotizing sialadenitis: a form of necrotizing sialometaplasia? (12975270)
2003
27
The intriguing association between prematurity and neonatal isolated submandibular suppurative sialadenitis. (11738693)
2002
28
Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1. (11937580)
2002
29
Comparison of the sonographic features of acalculous and calculous submandibular sialadenitis. (11424098)
2001
30
Relation of preoperative sialographic findings with histopathological diagnosis in cases of obstructive sialadenitis of the parotid and submandibular glands: retrospective study. (10475651)
1999
31
Chronic submandibular sialadenitis: ultrastructure and phosphatase histochemistry. (9891921)
1998
32
Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary SjAPgren's syndrome. (8806790)
1996
33
On focal lymphocytic sialadenitis as a gold standard for the diagnosis of SjAPgren's syndrome: comment on the article by Daniels and Whitcher. (7779134)
1995
34
Production of microliths and sialadenitis in rats by a short combined course of isoprenaline and calcium gluconate. (1518646)
1992
35
Chronic sialadenitis with psammoma bodies mimicking neoplasia in a fine-needle aspiration specimen from the submandibular gland. (2042598)
1991
36
Granulomatous sialadenitis. (1992904)
1991
37
Parotid gland enlargement and xerostomia associated with labial sialadenitis in HIV-infected patients. (2789646)
1989
38
Immunohistochemical analyses of autoimmune sialadenitis in man. (2464679)
1988
39
Chronic sialadenitis. An immunocytochemical study in humans. (2446419)
1987
40
Granulomatous sialadenitis of the major salivary glands. A clinicopathological study of 57 cases. (3570176)
1987
41
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
42
Sialadenitis following iodine-131 therapy for thyroid carcinoma. (4009293)
1985
43
Contrast induced sialadenitis--a case report. (6544850)
1984
44
Tuberculous sialadenitis. (7169448)
1982
45
Obstructive sialadenitis. An exercise in detection. (292440)
1979
46
Sialadenitis following treatment with alpha-methyldopa. (4821301)
1974
47
Sialadenitis after intravenous pyelography. (5558189)
1971
48
Lymphocytic sialadenitis in the buccal mucosa, in SjAPgren's disease, rheumatoid arthritis and other arthritides. A clinical and laboratory study. (5730757)
1968
49
CHRONIC SIALADENITIS IN CHILDHOOD. SIALOGRAPHIC OBSERVATIONS. (14236544)
1964
50
SODIUM IODIDE-INDUCED SUBMAXILLARY SIALADENITIS IN THE RAT. (14101183)
1963

Genetic Variations for Sialadenitis

About this section

Expression for genes affiliated with Sialadenitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

About this section
Sources:
12EMD Millipore, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG
See all sources

Pathways related to Sialadenitis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response NFAT in immune response
Hide members
9.7CD28, CD80, HLA-DQB1
2
Immune response ICOS pathway in T-helper cell
Hide members
9.7CD28, CD80, HLA-DQB1
3
Hide members
9.7HLA-DQB1, CD80, CD28
4
Hide members
9.7CD80, CD28, PTPRC
5
Hide members
9.6CD28, CD80, EBI3
69.5TNFSF13B, ITGAL, CD80, CD28
7
Hide members
9.5HSPG2, TIMP3, TNC, ITGAL, PLA2G3
89.3AMY1C, AMY1B, AMY1A
9
Hide members
9.3HLA-DQB1, CD80, CD28, PLA2G3, PTPRC
10
Hide members
9.3TIMP3, CCL23, TNFSF13B, ITGAL, CD80
11
Hide members
9.3CD28, CD80, ITGAL, HLA-DQB1, TIMP3
129.2HLA-DQB1, ITGAL, CD80, CD28, PTPRC
13
Hide members
9.0CD28, CALR, TNFSF13B, HLA-DQB1, ITGAL, CD80
14
Hide members
9.0CD28, CD80, TROVE2, SSB, HLA-DQB1
15
Hide members
8.5TIMP3, CCL23, TNFSF13B, OSM, ITGAL, CD80
16
Hide members
8.4TIMP3, CCL23, TNFSF13B, OSM, CD80, CD28
17
Hide members
8.2HSPG2, TIMP3, CCL23, TNC, TNFSF13B, OSM

Compounds for genes affiliated with Sialadenitis

About this section
Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Sialadenitis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.6HSPG2
2thymoglobulin4410.2PTPRC, CD28
3ctla4-ig4410.1CD28, CD80
4propranolol44 28 49 11 2414.0HSPG2, HTR3A, ITGAL
5serine449.9OSM
6heparin44 28 11 2412.7HSPG2, TIMP3, CALR, ITGAL, PTPRC
7glycosaminoglycan449.6OSM, TNC, TIMP3
8herbimycin a44 5910.6HSPG2, OSM, CD28, PTPRC
9phosphoinositide449.6HSPG2, CALR, TNC, ITGAL, CD28
10hyaluronic acid44 2410.6PTPRC, ITGAL, OSM, TNC
11ionomycin449.5CALR, ITGAL, CD80, CD28, PTPRC
12histamine44 28 2411.5HSPG2, CALR, HTR3A, OSM, PTPRC
13wortmannin449.4HSPG2, TIMP3, TNC, ITGAL, CD80, CD28
14h2o2449.4HSPG2, CALR, TNC, ITGAL, PTPRC
15genistein44 28 59 2 11 2414.4HSPG2, TIMP3, OSM, CD28, PTPRC
16oligonucleotide449.3CD28, HLA-DQB1, TNC, CALR, TIMP3
17ly294002449.3HSPG2, TIMP3, TNC, CD28
18retinoic acid44 2410.1HSPG2, TIMP3, CALR, TNC, OSM, ITGAL
19dexamethasone44 49 28 1112.0PTPRC, TIMP3, CALR, HTR3A, OSM, ITGAL
20cysteine448.9TIMP3, CALR, TNC, OSM, ITGAL, CD28
21lipid448.8TIMP3, CALR, TNC, OSM, ITGAL, CD28
22phosphatidylinositol448.8HSPG2, TIMP3, TNC, OSM, ITGAL, CD80
23tyrosine448.3HSPG2, TIMP3, CALR, TNC, OSM, HLA-DQB1
24calcium44 49 11 2410.5HSPG2, TIMP3, CCL23, AMY1A, CALR, TNC

GO Terms for genes affiliated with Sialadenitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9CALR, ITGAL, CD80, CD28, PTPRC
2extracellular spaceGO:0056158.3PLA2G3, HSPG2, CCL23, CALR, TNC, TNFSF13B
3plasma membraneGO:0058868.1TNFSF13B, HTR3A, HLA-DQB1, ITGAL, EBI3, CD80

Biological processes related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-2 biosynthetic processGO:0450869.6CD28, CD80
2positive regulation of alpha-beta T cell proliferationGO:0466419.6CD28, CD80, EBI3
3positive regulation of T cell proliferationGO:0421029.6PTPRC, CD28, ITGAL, TNFSF13B
4T cell costimulationGO:0312959.4TNFSF13B, HLA-DQB1, CD80, CD28
5immune responseGO:0069559.3HLA-DQB1, OSM, TNFSF13B, CCL23

Products for genes affiliated with Sialadenitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sialadenitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet