MCID: SLD003
MIFTS: 45

Sialadenitis malady

Categories: Rare diseases, Gastrointestinal diseases, Cardiovascular diseases, Oral diseases, Immune diseases, Endocrine diseases

Aliases & Classifications for Sialadenitis

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Aliases & Descriptions for Sialadenitis:

Name: Sialadenitis 11 46 13 48 37 66
Sialoadenitis 11 46
 
Salivary Gland Inflammation 46
Adenitis, Salivary Gland 46

Classifications:



External Ids:

Disease Ontology11 DOID:10303
ICD1028 K11.2, K11.20
ICD9CM30 527.2
MeSH37 D012793

Summaries for Sialadenitis

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NIH Rare Diseases:46 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/17/2014

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to xanthogranulomatous sialadenitis and igg4-related dacryoadenitis and sialadenitis, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (Tumor Necrosis Factor Superfamily Member 13b), and among its related pathways are Cytokines and Inflammatory Response and Rheumatoid arthritis. Affiliated tissues include salivary gland, t cells and thyroid, and related mouse phenotypes are muscle and respiratory system.

Wikipedia:69 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1xanthogranulomatous sialadenitis12.1
2igg4-related dacryoadenitis and sialadenitis12.1
3igg4-related submandibular gland disease10.9
4parsonage turner syndrome10.7HLA-DQB1, TNF
5myopathy-growth delay-intellectual disability-hypospadias syndrome10.7HLA-DQB1, TNF
6krieble bixler syndrome10.7HLA-DQB1, TNF
7keratomalacia10.6HLA-DQB1, TNF
8lymphocytic colitis10.6HLA-DQB1, TNF
9peripheral t-cell lymphoma10.6HLA-DQB1, TNF
10cerebral atrophy10.6MMP2, TNF
11lipodermatosclerosis10.6HLA-DQB1, TNF
12limb reduction defect10.5MMP2, TNC
13idiopathic central precocious puberty10.5HLA-DQB1, TNF
14intestinal benign neoplasm10.5MMP2, TNC
15sensorineural hearing loss10.5HLA-DQB1, TNF
16night blindness10.5CD4, TNF
17chronic hiccups10.4CD4, TNFSF13B
18ethmoid sinus adenoid cystic carcinoma10.4CD4, TNF
19neurotic excoriation10.4CD4, TNF
20ampulla of vater neoplasm10.4HLA-DQB1, TNF
21inhalation anthrax10.4CD4, TNC
22brain stem angioblastoma10.4TNC, TNF, TNFSF13B
23scleral disease10.4CD4, TNF
24anal spasm10.4HTR3A, TNC
25trichosporonosis10.4CD4, TNF
26steatorrhea10.4CD4, TNF
27perforation of bile duct10.4HLA-DQB1, TNC, TNF
28suppurative uveitis10.4CD4, TNF
29schwannomatosis10.4MMP2, TIMP3
30papillary transitional carcinoma10.4CD4, TNF
31cauda equina syndrome10.3CD4, TNF
32pneumonic tularemia10.3CD4, TNF
33hereditary neuropathies10.3HLA-DQB1, HTR3A, TNF
34alkhurma hemorrhagic fever10.3CD4, TNF
35lymphoma10.2
36gait apraxia10.2CD4, TNF
37malignant histiocytosis10.2CD4, TNF
38allergic hypersensitivity disease10.2CD4, HLA-DQB1, TNF
39acute laryngopharyngitis10.2HSPG2, TNC
40capgras syndrome10.2CD4, CDSN
41foodborne botulism10.2CD4, TNF
42yellow fever10.2CD4, CDSN
43dacryoadenitis10.1
44neurilemmoma10.1CD4, TNF
45multicentric castleman disease10.1HLA-DQB1, TNFSF13B, TRIM21
46sialolithiasis10.1
47brachyolmia10.1CD4, MMP2, TNF
48gemistocytic astrocytoma10.1CD4, MMP2, TNF
49prostate cancer, progression and metastasis of10.1CD4, HLA-DQB1, TNF
50hepatitis10.1

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Hypertension, EssentialDeficiency Anemia
Heart DiseaseMucocele of Salivary Gland
SialolithiasisAcute Cystitis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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UMLS symptoms related to Sialadenitis:


salivary gland pain

Drugs & Therapeutics for Sialadenitis

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Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabPhase 1, Phase 21611174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dental Safety Profile of High-Dose Radioiodine TherapyCompletedNCT00439478Phase 4
2Rituximab in IgG4-related Disease: A Phase 1-2 TrialCompletedNCT01584388Phase 1, Phase 2
3The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid CancerRecruitingNCT01833650
4Cohort Study of IgG4RDRecruitingNCT01670695Phase 0
5Imaging Study of 3D-CBCT Sialography and MRI Sialography in Non Tumor Salivary DiseasesNot yet recruitingNCT02883140

Search NIH Clinical Center for Sialadenitis


Cochrane evidence based reviews: sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

34
Salivary gland, T cells, Thyroid, B cells, Lymph node, Liver, Endothelial

Animal Models for Sialadenitis or affiliated genes

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MGI Mouse Phenotypes related to Sialadenitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2HLA-DQB1, HSPG2, HTR3A, MMP2, TIMP3, TNF
2MP:00053888.0HLA-DQB1, HSPG2, MMP2, RAG1, TIMP3, TNF
3MP:00107717.5CD4, HSPG2, HTR3A, RAG1, TIMP3, TNF
4MP:00036316.8CD4, HLA-DQB1, HSPG2, HTR3A, MMP2, RAG1
5MP:00053786.6CD4, HLA-DQB1, HSPG2, HTR3A, MMP2, RAG1
6MP:00053876.4CD4, HLA-DQB1, HSPG2, HTR3A, MMP2, RAG1
7MP:00107686.3CD4, HLA-DQB1, HSPG2, HTR3A, MMP2, RAG1
8MP:00053976.2CD4, HLA-DQB1, HSPG2, HTR3A, MMP2, RAG1
9MP:00053766.0CD4, HLA-DQB1, HSPG2, HTR3A, MMP2, RAG1

Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50)    (show all 447)
idTitleAuthorsYear
1
IgG4 related sclerosing sialadenitis- a retrospective analysis. (27568667)
2016
2
Subacute Necrotizing Sialadenitis: A Series of Three Cases and Literature Review. (27008639)
2016
3
IgG4-related sialadenitis and SjAPgren's syndrome. (27318181)
2016
4
Imaging findings of obstructive sialadenitis due to an intraglandular foreign body. (27622423)
2016
5
Clinicopathological characteristics of immunoglobulin G4-related sialadenitis. (26194097)
2015
6
Chronic Sclerosing Sialadenitis of the Submandibular Gland as the Initial Symptom of IgG4-Related Disease: A Case Report. (26084640)
2015
7
Sialendoscopy in sialadenitis: an unselected cohort of 228 patients. (26333199)
2015
8
The anergy induction of M3 muscarinic acetylcholine receptor reactive CD4+ T cell suppresses experimental sialadenitis like SjAPgren's syndrome. (25891013)
2015
9
Chronic sialadenitis with marked lymphadenopathy mimicking lymphoma on FDG PET/CT. (24978334)
2014
10
The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease. (24593171)
2014
11
Salivary endoscopy for idiopathic chronic sialadenitis. (23712592)
2013
12
Pathology quiz case 1. IgG4-related sialadenitis as a presenting symptom of IgG4-related disease. (23429955)
2013
13
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
14
Bilateral carcinoma in situ of Wharton's duct after chronic obstructive sialadenitis: inflammation as the cause of malignancy? (22724274)
2012
15
Sialoendoscopy in the diagnosis and management of obstructive sialadenitis. (21298637)
2011
16
IgG4-associated sialadenitis. (21124091)
2011
17
Simultaneous occurrence of IgG4-related chronic sclerosing dacryoadenitis and chronic sclerosing sialadenitis associated with lymph node involvement and Warthin's tumor. (19117975)
2011
18
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
19
Pathology quiz case 2. Chronic sclerosing sialadenitis (CSS). (19289717)
2009
20
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
21
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
22
Fibroblasts in chronic submandibular sialadenitis. (19076551)
2008
23
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
24
Surgical treatment of chronic parotid sialadenitis. (17166325)
2007
25
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
26
Acute ischemic sialadenitis following facial artery embolization. (15129338)
2004
27
Characterization of lymphoid infiltrates in chronic obstructive sialadenitis associated with sialolithiasis. (15078491)
2004
28
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
29
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
30
Vascular endothelial cell participation in formation of lymphoepithelial lesions (epi-myoepithelial islands) in lymphoepithelial sialadenitis (benign lymphoepithelial lesion). (12761623)
2003
31
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
32
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
33
Sonographic analysis of rat submandibular glands in experimentally-induced sialadenitis. (10808222)
2000
34
Lymphoma presenting as parotid xanthogranulomatous sialadenitis. (9881792)
1998
35
Microlithiasis in parotid sialadenosis and chronic submandibular sialadenitis is related to the microenvironment: an ultrastructural and microanalytical investigation. (9675592)
1998
36
Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. (9409649)
1997
37
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
38
Detection of cytomegalovirus and Epstein-Barr virus in labial salivary glands in Sjogren's syndrome and non-specific sialadenitis. (7473264)
1995
39
Autoimmune sialadenitis: a form of onset of SjAPgren's syndrome? (7653940)
1995
40
Scintigraphic evaluation of sialadenitis. (8173870)
1994
41
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
42
Sialadenitis associated with periorbital disease in a dog. (8360092)
1993
43
Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction. (2036674)
1991
44
Radionuclide imaging of potassium iodide-induced sialadenitis. (3034466)
1987
45
Bilateral obstructive sialadenitis of the submandibular glands due to a denture. (3474000)
1987
46
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
47
Contrast induced sialadenitis--a case report. (6544850)
1984
48
Sialadenosis and sialadenitis. Pathophysiological and diagnostic aspects. (7257944)
1981
49
SODIUM IODIDE-INDUCED SUBMAXILLARY SIALADENITIS IN THE RAT. (14101183)
1963
50
THE ROLE OF SIALOGRAPHY IN THE DIAGNOSIS AND THERAPY OF CHRONIC OBSTRUCTIVE SIALADENITIS. (14079987)
1963

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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GO Terms for genes affiliated with Sialadenitis

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Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00056049.5HSPG2, TIMP3, TNC
2extracellular matrixGO:00310128.8HSPG2, MMP2, TIMP3, TNC
3extracellular spaceGO:00056158.0HSPG2, MMP2, TIMP3, TNC, TNF, TNFSF13B
4extracellular regionGO:00055767.7HSPG2, MMP2, TIMP3, TNC, TNF, TNFSF13B

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:00312959.1CD4, HLA-DQB1, TNFSF13B
2extracellular matrix organizationGO:00301989.0HSPG2, TNC, TNF
3immune responseGO:00069558.8CD4, HLA-DQB1, RAG1, TNFSF13B

Molecular functions related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.9TNF, TNFSF13B

Sources for Sialadenitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet