MCID: SLD003
MIFTS: 40

Sialadenitis malady

Categories: Rare diseases, Gastrointestinal diseases, Cardiovascular diseases, Oral diseases, Immune diseases, Endocrine diseases

Aliases & Classifications for Sialadenitis

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Aliases & Descriptions for Sialadenitis:

Name: Sialadenitis 10 45 47 12 36 65
Sialoadenitis 10 45
 
Salivary Gland Inflammation 45
Adenitis, Salivary Gland 45

Classifications:



External Ids:

Disease Ontology10 DOID:10303
ICD1027 K11.2, K11.20
ICD9CM29 527.2
MeSH36 D012793
NCIt42 C26882
UMLS65 C0037023

Summaries for Sialadenitis

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NIH Rare Diseases:45 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/17/2014

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to syndactyly and artery disease. An important gene associated with Sialadenitis is TNFSF13B (Tumor Necrosis Factor Superfamily Member 13b), and among its related pathways are Cytokines and Inflammatory Response and Rheumatoid arthritis. Affiliated tissues include salivary gland, endothelial and breast, and related mouse phenotypes are integument and digestive/alimentary.

Wikipedia:68 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 368)
idRelated DiseaseScoreTop Affiliating Genes
1syndactyly30.3HSPG2, TNC
2artery disease30.2HLA-DQB1, TNF
3systemic lupus erythematosus30.0HLA-DQB1, TNF, TNFSF13B, TRIM21
4xanthogranulomatous sialadenitis12.4
5igg4-related dacryoadenitis and sialadenitis12.4
6igg4-related submandibular gland disease11.3
7hypercalcemic sarcoidosis10.4TNC, TNF
8autoimmune polyglandular syndrome type 210.4HLA-DQB1, TNF
9best1 retinopathy10.4HLA-DQB1, TNF
10non-distal monosomy 10q10.4HLA-DQB1, TNF
11lymphocytic choriomeningitis10.4HLA-DQB1, TNF
12moderately severe hemophilia a10.4HLA-DQB1, TNF
13cytoplasmic body myopathy10.4HLA-DQB1, TNF
14argentine hemorrhagic fever10.4HSPG2, TNF
15duodenum cancer10.4HLA-DQB1, TNF
16chronic hiccups10.4CD4, TNFSF13B
17megacolon10.4HTR3A, TNC
18ethmoid sinus squamous cell carcinoma10.4CD4, TNF
19achalasia10.3CD4, TNF
20hepatoid adenocarcinoma10.3HLA-DQB1, TNF
21fusariosis10.3CD4, TNF
22zebra body myopathy10.3HTR3A, TNF
23desquamative interstitial pneumonia10.3CD4, TNC
24prostate transitional cell carcinoma10.3CD4, TNF
25kernicterus due to isoimmunization10.3HLA-DQB1, TNF
26neuritis10.3CDSN, HSPG2
27parotitis10.3
28streptococcal meningitis10.3CD4, TNF
29b cell deficiency10.3CD4, TNF
30conjunctival degeneration10.3CDSN, HSPG2
31aniseikonia10.3CD4, TNF
32mycotic corneal ulcer10.3CD4, HSPG2
33chromosome 9p deletion syndrome10.3CD4, TNF
34soft palate cancer10.3CD4, TNF
35chronic tic disorder10.3CD4, TNF
36idiopathic juxtafoveal retinal telangiectasia10.3HLA-DQB1, TRIM21
37prostatitis10.3
38cerebellar angioblastoma10.3TNC, TNF, TNFSF13B
39opportunistic bacterial infectious disease10.3CD4, TNF
40myositis ossificans10.3CD4, CDSN
41cerebral sarcoidosis10.3AQP5, TNF
42meige syndrome10.2CD4, TNF
43congenital nasal pyriform aperture stenosis with holoprosencephaly10.2TNF, TRIM21
44cryoglobulinemia10.2CD4, TNF
45cervical incompetence10.2CD4, CDSN
46pancreatitis10.2
47constant exophthalmos10.2CD4, TNF
48adenocarcinoma10.2
49bacterial exanthem10.2CD4, HSPG2
50byssinosis10.2CD4, HLA-DQB1, TNF

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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Drugs & Therapeutics for Sialadenitis

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Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 1, Phase 21582174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2Immunologic FactorsPhase 1, Phase 218483
3Antirheumatic AgentsPhase 1, Phase 28496

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dental Safety Profile of High-Dose Radioiodine TherapyCompletedNCT00439478Phase 4
2Rituximab in IgG4-related Disease: A Phase 1-2 TrialCompletedNCT01584388Phase 1, Phase 2
3The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid CancerRecruitingNCT01833650
4Cohort Study of IgG4RDRecruitingNCT01670695Phase 0

Search NIH Clinical Center for Sialadenitis


Cochrane evidence based reviews: sialadenitis

Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

33
Salivary gland, Endothelial, Breast, Thyroid, Liver, Lung, T cells

Animal Models for Sialadenitis or affiliated genes

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MGI Mouse Phenotypes related to Sialadenitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.0CD4, HSPG2, HTR3A, RAG1, TNF, TRIM21
2MP:00053817.7AQP5, CD4, HLA-DQB1, HSPG2, RAG1, TNF
3MP:00053977.1CD4, HLA-DQB1, HSPG2, HTR3A, RAG1, TNF
4MP:00053876.8CD4, HLA-DQB1, HSPG2, HTR3A, RAG1, TNF
5MP:00053766.4AQP5, CD4, HLA-DQB1, HSPG2, HTR3A, RAG1

Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50)    (show all 424)
idTitleAuthorsYear
1
Electrocardiographic predictors of peripartum cardiomyopathy. (27213852)
2016
2
Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways. (26704080)
2016
3
Genome-wide investigation of regional blood-based DNA methylation adjusted for complete blood counts implicates BNC2 in ovarian cancer. (24853948)
2014
4
Will mass drug administration eliminate lymphatic filariasis? Evidence from northern coastal Tanzania. (23014581)
2013
5
Isolated double-orifice mitral valve: an extremely rare and interesting anomaly. (23475994)
2013
6
Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver. (23973767)
2013
7
Primary liposarcoma of the stomach. (23934465)
2013
8
Early socio-communicative forms and functions in typical Rett syndrome. (23891731)
2013
9
Identification of functional nucleotide and haplotype variants in the promoter of the CEBPE gene. (23719191)
2013
10
Phonology matters: a comprehensive investigation of reading and spelling skills of school-age children with mild to moderate sensorineural hearing loss. (23858701)
2013
11
Treatment of status epilepticus: an international survey of experts. (23097138)
2013
12
Imaging features of sporadic breast cancer in women under 40 years old: 97 cases. (23918218)
2013
13
BMP2 induces osteoblast apoptosis in a maturation state and noggin-dependent manner. (22628200)
2012
14
p38 Mitogen-activated protein kinase is required for glucosamine-induced endothelial nitric oxide synthase uncoupling and plasminogen-activator inhibitor expression. (22572461)
2012
15
Intracerebellar haematoma simulating congenital medulloblastoma during neonatal period. (22700938)
2011
16
Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort. (21299752)
2011
17
Evidence for an interaction between Golli and STIM1 in store-operated calcium entry. (20629634)
2010
18
Sweat: a potential marker of clinical activity in panic disorder. (19855367)
2009
19
Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment. (18335034)
2008
20
Fluoride intake by children at risk for the development of dental fluorosis: comparison of regular dentifrices and flavoured dentifrices for children. (17823508)
2007
21
Candesartan cilexetil: a pharmacoeconomic review of its use in chronic heart failure and hypertension. (17129078)
2006
22
Large cystic cavernous angioma of the cerebellum mimicking pilocytic astrocytoma. (16821089)
2006
23
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. (16713581)
2006
24
Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole. (15383005)
2005
25
Monochorionic diamniotic infants without twin-to-twin transfusion syndrome. (16281049)
2005
26
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. (14662755)
2004
27
Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta). (15210820)
2004
28
Development of vascular endothelial growth factor receptor (VEGFR) kinase inhibitors as anti-angiogenic agents in cancer therapy. (15032727)
2004
29
Bone histomorphometric changes after liver transplantation for chronic cholestatic liver disease. (14672354)
2003
30
Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide. (14534525)
2003
31
Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker. (12391287)
2002
32
Combined chemotherapy and local treatment in the management of intraocular retinoblastoma. (11984802)
2002
33
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. (11696726)
2001
34
Fibroblast growth factor receptor 2 (FGFR2): genomic sequence and variations. (11856867)
2001
35
Spontaneous contractions of myometrium from humans, non-human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro. (11563467)
2001
36
Xp22.2-3 loss of heterozygosity is associated with germline BRCA1 mutation in ovarian cancer. (10684722)
2000
37
Brucellosis with acute acalculous cholecystitis. (11099103)
2000
38
Plasma interleukin-3 (IL-3) and IL-7 concentrations in children with homozygous beta-thalassemia. (9476461)
1997
39
Endoscopic biliary sphincterotomy and stone extraction in a child with choledocholithiasis complicating Byler's disease. (8985855)
1996
40
Dynamic effects of acid on Barrett's esophagus. An ex vivo proliferation and differentiation model. (8903332)
1996
41
Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy. (7638812)
1995
42
Molecular genetic studies of sporadic pituitary tumors. (8106627)
1994
43
Malondialdehyde, glutathione peroxidase, and superoxide dismutase in cerebrospinal fluid during cerebral vasospasm in monkeys. (1393841)
1992
44
Progressive dysphasic dementia with localized cerebral atrophy: report of an autopsy. (1703058)
1990
45
Pain and personality profiles in burning mouth syndrome. (3822501)
1987
46
Familial anetoderma. (3819070)
1987
47
Iridocyclitis is not characteristic of Still's disease. (4041093)
1985
48
Polymyositis presenting as sick sinus syndrome. (7122376)
1982
49
50

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7CD4, TNF
29.6HLA-DQB1, TNF, TNFSF13B
39.2CD4, RAG1

GO Terms for genes affiliated with Sialadenitis

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Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00069558.6CD4, RAG1, TNF, TNFSF13B

Sources for Sialadenitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet