MCID: SLD003
MIFTS: 49

Sialadenitis malady

Categories: Rare diseases, Gastrointestinal diseases, Cardiovascular diseases, Oral diseases, Immune diseases, Endocrine diseases

Aliases & Classifications for Sialadenitis

Aliases & Descriptions for Sialadenitis:

Name: Sialadenitis 12 50 52 42 14 69
Sialoadenitis 12 50
Salivary Gland Inflammation 50
Adenitis, Salivary Gland 50

Classifications:



External Ids:

Disease Ontology 12 DOID:10303
ICD10 33 K11.2 K11.20
ICD9CM 35 527.2
MeSH 42 D012793
UMLS 69 C0037023

Summaries for Sialadenitis

NIH Rare Diseases : 50 sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. sialadenitis most commonly affects the elderly and chronically ill especially those with dry mouth or who are dehydrated, but can also affected people of any age including newborn babies. diagnosis is usually made by clinical exam but a ct scan, mri scan or ultrasound may be done if the doctor suspects an abscess or to look for stones. treatment may include an antibiotic (if bacterial), warm compresses, increasing fluid intake and good oral hygiene. most salivary gland infections go away on their own or are cured with treatment. complications are not common. last updated: 11/8/2016

MalaCards based summary : Sialadenitis, also known as sialoadenitis, is related to tuberculosis and xanthogranulomatous sialadenitis, and has symptoms including salivary gland pain An important gene associated with Sialadenitis is TNFSF13B (TNF Superfamily Member 13b), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs rituximab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and b cells, and related phenotypes are hematopoietic system and immune system

Wikipedia : 71 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Related Diseases for Sialadenitis

Diseases related to Sialadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 29.1 CD4 CD8A TNF
2 xanthogranulomatous sialadenitis 12.0
3 igg4-related dacryoadenitis and sialadenitis 12.0
4 igg4-related submandibular gland disease 10.8
5 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DQB1 TNF
6 t-cell prolymphocytic leukemia 10.2 HLA-DQB1 TNF
7 serous conjunctivitis except viral 10.2 HSPG2 TNC
8 autosomal dominant intermediate charcot-marie-tooth 10.2 HLA-DQB1 TNF
9 distal trisomy 14q 10.2 HLA-DQB1 TNF
10 severe hemophilia a 10.2 TNF TRIM21
11 immune deficiency, familial variable 10.1 HLA-DQB1 TRIM21
12 prostate calculus 10.1 CD4 TNF
13 partial sensory epilepsy 10.1 HSPG2 TRIM21
14 steatitis 10.1 CD8A TNF
15 cryptococcosis 10.1 CD4 HLA-DQB1 TNF
16 lymphoma 10.1
17 hyperoxaluria, primary, type ii 10.1 CD8A TNF
18 ciliary discoordination, due to random ciliary orientation 10.1 CD4 TNFSF13B
19 benign lymphoepithelial lesion of salivary gland 10.1 HSPG2 TNFSF13B TRIM21
20 dermatitis herpetiformis 10.1 CD4 TNF
21 apple allergy 10.0 CD8A HLA-DQB1
22 hepatic encephalopathy 10.0 TNC TNF
23 adamantinoma of long bones 10.0 CDSN TRIM21
24 transient tic disorder 10.0 CD4 TNF
25 articulation disorder 10.0 TNF TNFSF13B TRIM21
26 alcoholic pancreatitis 10.0 CD4 CD8A
27 asthenopia 10.0 CDSN HSPG2 TRIM21
28 colloid adenoma 10.0 CD4 CD8A
29 retinal microaneurysm 10.0 CD4 CD8A
30 advanced sleep phase syndrome, familial, 1 10.0 CD4 HLA-DQB1 TNF TNFSF13B
31 scrotum melanoma 10.0 CD4 CD8A
32 dacryoadenitis 10.0
33 lipodystrophy, familial partial, type 1 10.0 CD8A TRIM21
34 cervix melanoma 10.0 CD4 CD8A
35 sialolithiasis 10.0
36 coronin-1a deficiency 10.0 CD4 CD8A
37 scrotum squamous cell carcinoma 9.9 CD4 CD8A
38 eczema herpeticum 9.9 CD4 CD8A
39 vestibule of mouth cancer 9.9 CD4 CD8A TNF
40 human immunodeficiency virus infectious disease 9.9 CD4 CD8A TNF
41 congenital hypothyroidism 9.9 CD4 CD8A TNF
42 phlyctenulosis 9.9 CD4 CD8A TNF
43 infundibulocystic basal cell carcinoma 9.9 CD4 CD8A
44 tularemia 9.9 CD4 CD8A TNF
45 hepatitis 9.9
46 pancreatitis 9.9
47 hepatitis c 9.9
48 autoimmune polyendocrine syndrome type 1 9.9 CD4 CD8A TNC
49 oral cavity cancer 9.9 CD4 CD8A TNF
50 newcastle disease 9.9 CD4 CD8A TNF

Comorbidity relations with Sialadenitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Hypertension, Essential
Mucocele of Salivary Gland Sialolithiasis

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to Sialadenitis

Symptoms & Phenotypes for Sialadenitis

UMLS symptoms related to Sialadenitis:


salivary gland pain

MGI Mouse Phenotypes related to Sialadenitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 CD4 CD8A HLA-DQB1 HSPG2 HTR3A MMP2
2 immune system MP:0005387 10.11 MMP2 RAG1 TIMP3 TNF TNFSF13B TRIM21
3 homeostasis/metabolism MP:0005376 10.1 TIMP3 TNC TNF TRIM21 CD4 HLA-DQB1
4 endocrine/exocrine gland MP:0005379 10 HLA-DQB1 HTR3A RAG1 TIMP3 TNF CD4
5 mortality/aging MP:0010768 9.96 CD4 CD8A HLA-DQB1 HSPG2 HTR3A MMP2
6 integument MP:0010771 9.92 CD4 CD8A HSPG2 HTR3A RAG1 TIMP3
7 muscle MP:0005369 9.63 HLA-DQB1 HSPG2 HTR3A MMP2 TIMP3 TNF
8 nervous system MP:0003631 9.61 CD4 CD8A HLA-DQB1 HSPG2 HTR3A MMP2
9 respiratory system MP:0005388 9.1 HLA-DQB1 HSPG2 MMP2 RAG1 TIMP3 TNF

Drugs & Therapeutics for Sialadenitis

Drugs for Sialadenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Antibodies Phase 1, Phase 2
3 Antirheumatic Agents Phase 1, Phase 2
4 Immunoglobulin G Phase 1, Phase 2
5 Immunoglobulins Phase 1, Phase 2
6 Vaccines Phase 2
7
Acetaminophen Approved 103-90-2 1983
8
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
9
Lidocaine Approved, Vet_approved 137-58-6 3676
10
Morphine Approved, Investigational 57-27-2 5288826
11 Analgesics
12 Analgesics, Non-Narcotic
13 Anesthetics
14 Anesthetics, Local
15 Anti-Arrhythmia Agents
16 Anti-Inflammatory Agents
17 Anti-Inflammatory Agents, Non-Steroidal
18 Antipyretics
19 Central Nervous System Depressants
20 dipyrone
21 Diuretics, Potassium Sparing
22 Peripheral Nervous System Agents
23 Pharmaceutical Solutions
24 Proxymetacaine
25 Sodium Channel Blockers
26 Analgesics, Opioid
27 Narcotics

Interventional clinical trials:


id Name Status NCT ID Phase
1 Dental Safety Profile of High-Dose Radioiodine Therapy Completed NCT00439478 Phase 4
2 Rituximab in IgG4-related Disease: A Phase 1-2 Trial Completed NCT01584388 Phase 1, Phase 2
3 Phase II of Live Attenuated Mumps (F-genotype) Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Not yet recruiting NCT03133923 Phase 2
4 The Use of Candy and Honey in Decreasing Salivary Gland Damage Following Radioiodine Therapy for Thyroid Cancer Recruiting NCT01833650
5 A Prospective Cohort Study of IgG4RD in China Recruiting NCT01670695
6 SPI-directed Analgesia for Vitreoretinal Surgeries Recruiting NCT02973581
7 Imaging Study of 3D-CBCT Sialography and MRI Sialography in Non Tumor Salivary Diseases Not yet recruiting NCT02883140
8 Gender and Opioid Consumption Not yet recruiting NCT03006627

Search NIH Clinical Center for Sialadenitis

Cochrane evidence based reviews: sialadenitis

Genetic Tests for Sialadenitis

Anatomical Context for Sialadenitis

MalaCards organs/tissues related to Sialadenitis:

39
Salivary Gland, T Cells, B Cells, Thyroid, Lymph Node, Liver, Tongue

Publications for Sialadenitis

Articles related to Sialadenitis:

(show top 50) (show all 459)
id Title Authors Year
1
18F-FDG PET/CT Features of Chronic Sclerosing Sialadenitis Presenting as Localized IgG4-Related Disease. ( 28060780 )
2017
2
Diffusion-weighted MRI for differentiation between sialadenitis and pleomorphic adenoma. ( 27845594 )
2017
3
Imaging of sialadenitis. ( 28059621 )
2017
4
A review of acute postoperative sialadenitis in children. ( 28012533 )
2017
5
Pathogenic role of endogenous TNF-I+ in the development of SjAPgren's-like sialadenitis and secretory dysfunction in non-obese diabetic mice. ( 28067896 )
2017
6
Reply to letter "Therapeutic ductal injection in chronic sialadenitis is established". ( 27637754 )
2016
7
IgG4 related sclerosing sialadenitis- a retrospective analysis. ( 27568667 )
2016
8
Uncommon situation and presentation of chronic sclerosing sialadenitis. ( 26968047 )
2016
9
Tubercular sialadenitis of parotid gland - An extremely rare case series. ( 27998500 )
2016
10
Sonographic findings of immunoglobulin G4-related sclerosing sialadenitis. ( 26707999 )
2016
11
Persistence of focal lymphocytic sialadenitis in patients with primary SjAPgren's syndrome treated with rituximab: a possible role for glandular BAFF. ( 27494407 )
2016
12
Masseteric Myositis: A Unique Cause of Obstructive Sialadenitis of Parotid Gland. ( 28068299 )
2016
13
Subacute Necrotizing Sialadenitis: A Series of Three Cases and Literature Review. ( 27008639 )
2016
14
The role of interventional sialendoscopy and intraductal steroid therapy in patients with recurrent sine causa sialadenitis: a prospective cross-sectional study. ( 27200511 )
2016
15
IgG4-related sialadenitis and SjAPgren's syndrome. ( 27318181 )
2016
16
Geographic tongue associated with sialadenitis. ( 27726175 )
2016
17
Diagnostic Utility of Acoustic Structure Quantification for Evaluation of Radiation Sialadenitis after Radioactive Iodine Therapy. ( 27543124 )
2016
18
Differential diagnosis of IgG4-related sialadenitis, primary SjAPgren syndrome, and chronic obstructive submandibular sialadenitis. ( 27866757 )
2016
19
Sialendoscopy-assisted surgery and the chronic obstructive sialadenitis symptoms questionnaire: A prospective study. ( 26972293 )
2016
20
Massive sialadenitis resulting in critical airway after elective craniotomy: case report. ( 27258589 )
2016
21
Therapeutic ductal injection in chronic sialadenitis is established. ( 27619821 )
2016
22
Acute postoperative sialadenitis after retrosigmoid craniotomies. ( 27402408 )
2016
23
Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis. ( 27822398 )
2016
24
Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy-assisted salivary duct surgery. ( 27701754 )
2016
25
Lipoma of the cheek presenting with recurrent sialadenitis of the right parotid gland: a case report. ( 27809889 )
2016
26
Clinicopathology of Immunoglobulin G4-Related Chronic Sclerosing Sialadenitis: A Single-Center Study. ( 27576683 )
2016
27
Captopril-induced sialadenitis in a patient with end-stage renal disease. ( 27162811 )
2016
28
Imaging findings of obstructive sialadenitis due to an intraglandular foreign body. ( 27622423 )
2016
29
Diagnostic Challenges in the Fine Needle Aspiration Biopsy of Chronic Sclerosing Sialadenitis (KA1ttner's Tumor) in the Context of Head and Neck Malignancy: A Series of 4 Cases. ( 26909791 )
2016
30
RORI^t antagonist suppresses M3 muscarinic acetylcholine receptor-induced SjAPgren's syndrome-like sialadenitis. ( 27643385 )
2016
31
Immunoglobulin G4 related chronic sclerosing sialadenitis. ( 25797447 )
2015
32
IgG4-related sialadenitis: IgG4 is helpful, but biopsies are still crucial. ( 26684829 )
2015
33
Interleukin 13-positive mast cells are increased in immunoglobulin G4-related sialadenitis. ( 25571893 )
2015
34
Ulcerative sialadenitis of minor salivary gland: A short case report. ( 26752884 )
2015
35
Neonatal suppurative sialadenitis: an important clinical diagnosis. ( 26002665 )
2015
36
Sialendoscopy-assisted treatment for radioiodine-induced sialadenitis. ( 25544300 )
2015
37
The Chronic Obstructive Sialadenitis Symptoms Questionnaire to assess sialendoscopy-assisted surgery. ( 26256263 )
2015
38
Immune complexome analysis of antigens in circulating immune complexes isolated from patients with IgG4-related dacryoadenitis and/or sialadenitis. ( 26166493 )
2015
39
Is lymphocytic sialadenitis IgG4-related? ( 25665016 )
2015
40
Effectiveness of imaging modalities for screening IgG4-related dacryoadenitis and sialadenitis (Mikulicz's disease) and for differentiating it from SjAPgren's syndrome (SS), with an emphasis on sonography. ( 26298875 )
2015
41
Sialadenitis after radioiodine therapy. Analysis of factors that influence the response to medical treatment. ( 26459118 )
2015
42
Chronic Sclerosing Sialadenitis of the Submandibular Gland as the Initial Symptom of IgG4-Related Disease: A Case Report. ( 26084640 )
2015
43
Internal Organ Involvement in IgG4-related Sialadenitis: A Systemic Review. ( 26167546 )
2015
44
Near-Total Pediatric Parotidectomy for Refractory Chronic Sialadenitis. ( 26359705 )
2015
45
Comorbid diseases of IgG4-related sialadenitis in the head and neck region. ( 25994602 )
2015
46
Sialendoscopy in sialadenitis: an unselected cohort of 228 patients. ( 26333199 )
2015
47
Sialadenitis following low dose I-131 diagnostic thyroid scan with ThyrogenAr (recombinant human thyroid stimulating hormone--thyrotropin alfa). ( 26622936 )
2015
48
Obstructive Wharton Duct Sialadenitis. ( 26153032 )
2015
49
A crucial role of RORI^t in the development of spontaneous Sialadenitis-like SjAPgren's syndrome. ( 25411202 )
2015
50
Usefulness of Magnetic Resonance Sialography for the Evaluation of Radioactive Iodine-Induced Sialadenitis. ( 26242362 )
2015

Variations for Sialadenitis

Expression for Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for Sialadenitis

Pathways related to Sialadenitis according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 CD4 HLA-DQB1 MMP2 RAG1 TNF TNFSF13B
2
Show member pathways
12.51 CD4 CD8A HLA-DQB1 TNF TNFSF13B
3 12.31 CD8A RAG1 TNF TNFSF13B
4 11.93 HSPG2 MMP2 TIMP3 TNF
5 11.87 CD4 CD8A HLA-DQB1
6 11.77 CD4 CD8A TNF
7 11.63 HLA-DQB1 TNF TNFSF13B
8 11.59 MMP2 TIMP3 TNC
9 11.54 CD4 CD8A TNF
10 11.49 CD4 CD8A TNF
11 11.43 CD4 CD8A HLA-DQB1
12
Show member pathways
11.25 HSPG2 MMP2 TIMP3 TNF
13 11.02 CD4 TNF
14 10.91 CD4 CD8A HLA-DQB1 TNF
15 10.9 CD4 CD8A RAG1

GO Terms for Sialadenitis

Cellular components related to Sialadenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 CD8A HSPG2 MMP2 TIMP3 TNC TNF
2 extracellular space GO:0005615 9.8 HSPG2 MMP2 TIMP3 TNC TNF TNFSF13B
3 proteinaceous extracellular matrix GO:0005578 9.46 HSPG2 MMP2 TIMP3 TNC
4 T cell receptor complex GO:0042101 9.26 CD4 CD8A
5 extracellular matrix GO:0031012 9.26 HSPG2 MMP2 TIMP3 TNC
6 basement membrane GO:0005604 8.8 HSPG2 TIMP3 TNC

Biological processes related to Sialadenitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of calcium-mediated signaling GO:0050850 9.32 CD4 CD8A
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.26 MMP2 TNF
3 positive regulation of viral entry into host cell GO:0046598 9.16 CD4 TRIM21
4 T cell costimulation GO:0031295 9.13 CD4 HLA-DQB1 TNFSF13B
5 immune response GO:0006955 9.1 CD4 CD8A HLA-DQB1 RAG1 TNF TNFSF13B

Sources for Sialadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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