MCID: SLD003
MIFTS: 59

Sialadenitis malady

Rare diseases, Gastrointestinal diseases, Oral diseases, Endocrine diseases categories
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Summaries for Sialadenitis

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NIH Rare Diseases:42 Sialadenitis is an infection of the salivary glands. it is usually caused by a virus or bacteria. the parotid (in front of the ear) and submandibular (under the chin) glands are most commonly affected. sialadenitis may be associated with pain, tenderness, redness, and gradual, localized swelling of the affected area. there are both acute and chronic forms. although it is quite common among elderly adults with salivary gland stones, sialadenitis can also occur in other age groups, including infants during the first few weeks of life. without proper treatment, sialadenitis can develop into a severe infection, especially in people who are debilitated or elderly.  last updated: 9/17/2014

MalaCards based summary: Sialadenitis, also known as sialoadenitis, is related to b-cell lymphomas and arthritis. An important gene associated with Sialadenitis is HSPG2 (heparan sulfate proteoglycan 2), and among its related pathways are Cytokines and Inflammatory Response and IL12 signaling mediated by STAT4. The compounds cicaprost and abatacept have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and b cells, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:65 Sialadenitis (sialoadenitis) is inflammation of a salivary gland. It may be subdivided temporally into... more...

Aliases & Classifications for Sialadenitis

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Sialadenitis, Aliases & Descriptions:

Name: Sialadenitis 8 42 10 44 62
Sialoadenitis 8 42 62
Salivary Gland Inflammation 42 62
 
Adenitis, Salivary Gland 42
Sialoadenitis Nos 8


Classifications:



External Ids:

Disease Ontology8 DOID:10303
ICD9CM27 527.2
MeSH34 D012793
NCIt39 C26882
ICD1025 K11.2

Related Diseases for Sialadenitis

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Diseases related to Sialadenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas30.8TNFSF13B, CD80, ITGAL
2arthritis30.7TNF, OSM
3hepatitis c30.6CD28, CD4, TIMP3, HSPG2
4hodgkin's lymphoma30.5TNFSF13B, CD80, EBI3, CD28
5sjogren's syndrome30.3CD80, CD28, TNFSF13B, HSPG2, ITGAL
6vasculitis30.1TNFSF13B, CD80, TNF
7connective tissue disease30.1CD4, TNF
8t-cell leukemia30.0CD28, CD4, ITGAL
9adenoma29.9TNC, HSPG2, OSM, TIMP3
10tuberculosis29.6ITGAL, TNF, CD4, HLA-DQB1
11sarcoidosis29.5CD28, CD4, TNF, HLA-DQB1, CD80
12osteoarthritis29.4TNF, OSM, MMP2, CD80, TIMP3
13leukemia29.3OSM, CD80, CD4, ITGAL, HTR3A, TNF
14rheumatoid arthritis28.3TNFSF13B, TIMP3, MMP2, ITGAL, CD4, CD28
15xanthogranulomatous sialadenitis10.4
16nodular goiter10.4CD28, CD80
17extrinsic allergic alveolitis10.4CD28, ITGAL
18mast cell neoplasm10.4CD80, ITGAL
19mycobacterium avium complex disease10.4CD4
20listeriosis10.4CD4
21central nervous system lymphoma10.4CD4
22cryptococcosis10.4CD4
23histoplasmosis10.4CD4
24polymyositis10.4CD28, CD80, HSPG2
25common variable immunodeficiency10.3CD28, TNFSF13B
26hepatitis10.3
27sialolithiasis10.3
28dacryoadenitis10.3
29spondylarthropathy10.3ITGAL, TNF
30myocarditis10.3CD4
31chronic lymphocytic leukemia10.3TNFSF13B, CD80, ITGAL
32arthropathy10.3TNF, OSM
33leishmaniasis10.3CD4
34leprosy10.3CD4
35mumps10.3
36thyroiditis10.3
37retroperitoneal fibrosis10.3
38graft versus host disease10.2CD28, ITGAL, TNF
39pulmonary sarcoidosis10.2TNF, ITGAL, CD80
40pancreatitis10.2
41hepatitis c virus10.2
42non-hodgkin lymphoma10.2CD80, CD28, TNFSF13B, ITGAL
43thyroid hurthle cell carcinoma10.2TNC, HSPG2, TIMP3
44bullous pemphigoid10.2ITGAL, TNFSF13B, HLA-DQB1
45tetanus10.2CD4, CD28, CD80
46myelitis10.2
47keratoconjunctivitis sicca10.2
48keratoconjunctivitis10.2
49chagas disease10.2CD28, CD4
50acute myocardial infarction10.2ITGAL, HTR3A, TNC

Graphical network of the top 20 diseases related to Sialadenitis:



Diseases related to sialadenitis

Symptoms for Sialadenitis

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Drugs & Therapeutics for Sialadenitis

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Drug clinical trials:

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Genetic Tests for Sialadenitis

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Anatomical Context for Sialadenitis

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MalaCards organs/tissues related to Sialadenitis:

32
Salivary gland, T cells, B cells, Thyroid, Lymph node, Liver, Thymus, Lung, Endothelial, Tongue

Animal Models for Sialadenitis or affiliated genes

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Publications for Sialadenitis

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Articles related to Sialadenitis:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Chronic sialadenitis with marked lymphadenopathy mimicking lymphoma on FDG PET/CT. (24978334)
2014
2
Imaging in acute obstructive sialadenitis. (24712336)
2014
3
The role of cytotoxic T cells in IgG4-related dacryoadenitis and sialadenitis, the so-called Mikulicz's disease. (24593171)
2014
4
Salivary endoscopy for idiopathic chronic sialadenitis. (23712592)
2013
5
Prediction of risk for symptomatic sialadenitis by post-therapeutic dual (131)I scintigraphy in patients with differentiated thyroid cancer. (23921836)
2013
6
Superficial parotidectomy for chronic parotid sialadenitis. (22560869)
2013
7
Acute contralateral submandibular sialadenitis as a complication of skull base surgery. (21656260)
2012
8
Pediatric chronic sclerosing sialadenitis: KA1ttner tumor. (21985393)
2012
9
Tenascin-C in chronic sclerosing sialadenitis. (21559807)
2011
10
Sialoendoscopy in the diagnosis and management of obstructive sialadenitis. (21298637)
2011
11
Chronic Sclerosing Sialadenitis (KA1ttner's tumour) of the Parotid Gland. (22135562)
2010
12
Radiology quiz case 1. Chronic sclerosing sialadenitis of the submandibular gland. (20956754)
2010
13
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
14
Pathology quiz case 2. Chronic sclerosing sialadenitis (CSS). (19289717)
2009
15
Concurrent sialocoele and necrotising sialadenitis in a dog. (19261087)
2009
16
Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland (HSG) cells in vitro, suggests a role for the TNF receptor (TNF-R) and intercellular adhesion molecule-1 (ICAM-1) in SjAPgren's syndrome-associated autoimmune sialadenitis. (19716548)
2009
17
Reducing the incidence of 131I-induced sialadenitis: the role of pilocarpine. (18344428)
2008
18
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis. (18336373)
2008
19
Sialoendoscopic treatment for radioiodine induced sialadenitis. (17202942)
2007
20
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. (17900348)
2007
21
Surgical treatment of chronic parotid sialadenitis. (17166325)
2007
22
Sialadenitis of the left submandibular gland/sialolith. (16163878)
2005
23
Chronic sclerosing sialadenitis of the parotid gland: diagnosis using color Doppler sonography and sonographically guided needle biopsy. (15784774)
2005
24
Neonatal suppurative submandibular sialadenitis: case report and literature review. (15911021)
2005
25
Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice. (15763917)
2004
26
Acute ischemic sialadenitis following facial artery embolization. (15129338)
2004
27
Sialadenitis with crystalloid formation. Fine needle aspiration cytodiagnosis of 15 cases. (12585023)
2003
28
Transforming growth factor beta in chronic obstructive sialadenitis of human submandibular gland. (12642229)
2003
29
Re: Amin MA, Bailey BMW, Patel SR. Clinical and radiological evidence to support superficial parotidectomy as a treatment of choice for chronic parotid sialadenitis: a retrospective study. Br J Oral Maxillofac Surg 2001; 39: 348-352. (12379202)
2002
30
Chronic sialadenitis with pleomorphic adenoma of the parotid: coincidental or causal? (11793066)
2002
31
Subacute necrotizing sialadenitis in the buccal mucosa. (12465016)
2002
32
Reduced levels of insulin-like growth factor-1 receptor (IGF-1R) suppress cellular signaling in experimental autoimmune sialadenitis (EAS). (11693172)
2001
33
Relation of preoperative sialographic findings with histopathological diagnosis in cases of obstructive sialadenitis of the parotid and submandibular glands: retrospective study. (10475651)
1999
34
Lymphoma presenting as parotid xanthogranulomatous sialadenitis. (9881792)
1998
35
Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice. (9409649)
1997
36
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
37
On focal lymphocytic sialadenitis as a gold standard for the diagnosis of SjAPgren's syndrome: comment on the article by Daniels and Whitcher. (7779134)
1995
38
B-cell monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial sialadenitis and low-grade B-cell MALT lymphoma of the parotid gland. (7726362)
1995
39
Iodine-induced sialadenitis: report of 4 cases and review of the literature. (8459885)
1993
40
Lymphocytic sialadenitis of SjAPgren's syndrome associated with chronic hepatitis C virus liver disease. (1346409)
1992
41
Experimental autoallergic sialadenitis in the LEW rat. I. Parameters of disease induction. (2036674)
1991
42
Radionuclide imaging of potassium iodide-induced sialadenitis. (3034466)
1987
43
Bilateral obstructive sialadenitis of the submandibular glands due to a denture. (3474000)
1987
44
Sialadenitis in children. (3744701)
1986
45
Pan-sialadenitis due to Staphylococcus aureus septicemia. (3020643)
1986
46
Oxyphenbutazone-induced sialadenitis, intrahepatic cholestasis and pancreatitis. (3832725)
1985
47
Contrast induced sialadenitis--a case report. (6544850)
1984
48
Diagnosis please. Benign follicular hyperplasia of a submandibular lymph node and chronic sialadenitis. (4516846)
1973
49
SODIUM IODIDE-INDUCED SUBMAXILLARY SIALADENITIS IN THE RAT. (14101183)
1963
50
Chronic sialadenitis and sialography. (14370773)
1955

Variations for Sialadenitis

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Expression for genes affiliated with Sialadenitis

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Expression patterns in normal tissues for genes affiliated with Sialadenitis

Search GEO for disease gene expression data for Sialadenitis.

Pathways for genes affiliated with Sialadenitis

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Pathways related to Sialadenitis according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CD4, TNF
29.7CD28, CD4
3
Show member pathways
9.7CD28, CD4
49.6CD28, CD80
59.6CD28, CD80
6
Show member pathways
9.6CD28, CD80
7
Show member pathways
9.6TIMP3, TNF, TNFSF13B
89.6MMP2, TIMP3, TNC
9
Show member pathways
9.6TNC, TIMP3, MMP2
10
Show member pathways
9.5TNF, TNFSF13B, HLA-DQB1
11
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.4CD28, CD4, HLA-DQB1
129.4ITGAL, HSPG2, TNC
13
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4CD4, MMP2, TNF
14
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.4CD80, HSPG2, TNF
15
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.4TNF, CD4, CD28
16
Show member pathways
9.3CD4, CD28, CD80
17
Show member pathways
TCR signaling in naive CD8+ T cells37
9.3CD80, CD28, CD4
18
Show member pathways
9.3TNF, HSPG2, TIMP3, MMP2
199.3TNF, HSPG2, TIMP3, MMP2
20
Show member pathways
9.3EBI3, TNF
21
Show member pathways
9.2TNC, HSPG2, TIMP3, ITGAL
22
Show member pathways
9.1TNC, HSPG2, MMP2, ITGAL
23
Show member pathways
9.0ITGAL, MMP2, TIMP3, TNF
24
Show member pathways
9.0HLA-DQB1, CD4, CD28, CD80
25
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.0HLA-DQB1, CD4, CD28, CD80
26
Show member pathways
9.0CD80, CD28, CD4, HLA-DQB1
27
Show member pathways
9.0CD80, CD28, CD4, HLA-DQB1
28
Show member pathways
8.7CD80, CD28, HSPG2, TNF, HLA-DQB1
29
Show member pathways
8.5TNC, HSPG2, MMP2, CCL23, ITGAL
30
Show member pathways
8.5HLA-DQB1, ITGAL, CD4, CD28, CD80
318.5HLA-DQB1, ITGAL, CD4, CD28, CD80
328.2HLA-DQB1, TNFSF13B, TNF, ITGAL, CD28, CD80
33
Show member pathways
IL27-mediated signaling events37
8.1EBI3, TNF, CD4, CD28, CD80
34
Show member pathways
7.9HLA-DQB1, TIMP3, MMP2, ITGAL, CD4, CD28
35
Show member pathways
7.8HLA-DQB1, TNFSF13B, TNF, ITGAL, CD4, CD28
36
Show member pathways
7.7TNFSF13B, TNF, TIMP3, CCL23, ITGAL, CD4
37
Show member pathways
7.5TNFSF13B, TNF, OSM, CCL23, CD4, CD28
38
Show member pathways
7.3TNFSF13B, TNF, OSM, TIMP3, CCL23, CD4
39
Show member pathways
6.8TNFSF13B, TNF, OSM, TIMP3, CCL23, ITGAL
40
Show member pathways
6.2CD80, TNC, TNFSF13B, TNF, HSPG2, OSM

Compounds for genes affiliated with Sialadenitis

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Compounds related to Sialadenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1cicaprost44 2811.0TNF, HSPG2
2abatacept44 1111.0CD80, TNF
3cilomilast4410.0MMP2, TNF
4bcma449.9TNFSF13B, TNF
5go 697644 6110.9HSPG2, MMP2, TNF
6ctla4-ig449.9CD80, CD28
7heparan sulfate44 2410.8HSPG2, TNC, TIMP3, CD4
8blys449.7TNFSF13B, TNF
9rituximab44 50 1111.7TNF, TNFSF13B, CD80
10n-formylmethionyl-leucylphenylalanine449.7TNF, HSPG2, ITGAL
11nickel44 2410.7HLA-DQB1, CD4, ITGAL
12glycosaminoglycan449.6TIMP3, OSM, TNC
13efalizumab44 1110.6ITGAL, TNF
14propranolol44 28 50 24 1113.5HTR3A, HSPG2, MMP2, ITGAL
15chloroquine44 2 50 28 1113.5ITGAL, TNF, CD4
16matrigel449.4TIMP3, TNC, OSM, MMP2
17phorbol449.4CD4, ITGAL, MMP2, TNC
18histamine44 28 2411.4OSM, TNF, HSPG2, HTR3A
19azathioprine44 2 50 1112.3ITGAL, OSM, MMP2
20phosphoinositide449.3TNC, CD28, ITGAL, HSPG2
21prednisolone44 28 1111.2MMP2, ITGAL, TNF
22heparin44 28 24 1112.2TIMP3, HSPG2, CD4, TNC, ITGAL
23oligonucleotide449.2TIMP3, CD28, CD4, TNC, HLA-DQB1
24hyaluronic acid44 2410.2ITGAL, MMP2, TNC, OSM
25pd 98,059449.2HSPG2, TNF, OSM, TIMP3, MMP2
26tgf beta1449.1OSM, TNF, MMP2, TNC, TIMP3
27ionomycin449.1TNF, CD28, ITGAL, CD80
28fibrinogen449.1OSM, ITGAL, TNF, TNC
29h2o2449.1MMP2, TNC, HSPG2, TNF, ITGAL
30ly294002449.0MMP2, CD28, TNF, TIMP3, TNC, HSPG2
31vegf448.9MMP2, TNF, HSPG2, OSM, TIMP3, TNC
32cyclosporin a44 28 6110.8ITGAL, CD28, CD80, TNF
33proline448.8CD28, CD4, MMP2, ITGAL, CD80
34herbimycin a44 619.7CD28, TNF, HSPG2, CD4, OSM, MMP2
35alanine448.7HSPG2, OSM, MMP2, CD4, ITGAL, TNFSF13B
36glutamate448.7MMP2, CD4, ITGAL, TIMP3, HSPG2, TNC
37rantes448.5ITGAL, CCL23, OSM, TNF, CD4
38genistein44 28 61 2 24 1113.5CD4, MMP2, TIMP3, OSM, HSPG2, TNF
39wortmannin448.4ITGAL, CD28, HSPG2, MMP2, TIMP3, TNC
40retinoic acid44 249.4OSM, TIMP3, MMP2, ITGAL, HSPG2, TNF
41cysteine448.2TNC, OSM, TIMP3, ITGAL, MMP2, CD4
42lipid448.2TNC, CD28, TIMP3, OSM, TNF, CD4
43oxygen44 249.2TNF, CD80, CD28, ITGAL, TIMP3
44pge2448.1OSM, CD80, CD4, ITGAL, TNF, HSPG2
45serine447.9OSM, HSPG2, CD4, TNF, TNC, MMP2
46cycloheximide447.9TNC, TNF, OSM, MMP2, ITGAL, HSPG2
47dexamethasone44 50 28 1110.6CD28, TIMP3, CD80, TNC, TNF, HSPG2
48phosphatidylinositol447.6TNC, HSPG2, OSM, TIMP3, MMP2, ITGAL
49tyrosine447.3CD80, CD28, CD4, ITGAL, MMP2, HLA-DQB1
50calcium44 50 24 119.7CCL23, TNC, CD28, HSPG2, OSM, TIMP3

GO Terms for genes affiliated with Sialadenitis

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Cellular components related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.7TIMP3, HSPG2, TNC
2external side of plasma membraneGO:0098978.1TNF, ITGAL, CD4, CD28, CD80
3extracellular spaceGO:0056157.0CCL23, EBI3, TNC, TNFSF13B, TNF, HSPG2
4plasma membraneGO:0058866.1EBI3, HLA-DQB1, TNFSF13B, TNF, HSPG2, MMP2

Biological processes related to Sialadenitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of defense response to virus by virusGO:0506909.7CD28, CD4
2positive regulation of calcium-mediated signalingGO:0508509.5CD4, ITGAL
3positive regulation of interleukin-2 biosynthetic processGO:0450869.5CD80, CD4, CD28
4positive regulation of T cell proliferationGO:0421029.4TNFSF13B, ITGAL, CD28
5positive regulation of mitosisGO:0458409.4TNF, CD28
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2CD80, CD4, OSM
7positive regulation of alpha-beta T cell proliferationGO:0466419.0CD28, EBI3, CD80
8T cell costimulationGO:0312959.0CD80, CD28, HLA-DQB1, TNFSF13B, CD4
9humoral immune responseGO:0069598.9CD28, TNF, EBI3
10extracellular matrix organizationGO:0301988.9TNC, TNF, HSPG2, MMP2, ITGAL
11immune responseGO:0069558.6HLA-DQB1, TNFSF13B, OSM, CCL23, CD4

Molecular functions related to Sialadenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.8TNFSF13B, TNF
2coreceptor activityGO:0150269.3CD4, CD28, CD80
3cytokine activityGO:0051258.4OSM, TNF, TNFSF13B, EBI3
4protein bindingGO:0055156.2ITGAL, EBI3, TNFSF13B, TNF, HSPG2, TIMP3

Products for genes affiliated with Sialadenitis

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Sources for Sialadenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet