Sialolithiasis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Wikipedia:⁶⁸ Sialolithiasis (also termed salivary calculi, or salivary stones), is a condition where a calcified mass... more...

MalaCards based summary: Sialolithiasis, also known as stone of salivary gland or duct, is related to best1 retinopathy and non-distal monosomy 10q, and has symptoms including sialectasia nosand salivary gland pain. An important gene associated with Sialolithiasis is ACBD6 (Acyl-CoA Binding Domain Containing 6), and among its related pathways are Downstream signaling in naive CD8+ T cells and IL12-mediated signaling events. Affiliated tissues include salivary gland, lung and b cells, and related mouse phenotypes are normal and endocrine/exocrine gland.

Related Diseases for Sialolithiasis

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics, ⁶⁵UMLS
See all MalaCards sources

Diseases related to Sialolithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)

id	Related Disease	Score	Top Affiliating Genes
1	best1 retinopathy	10.7	HLA-DPB1, HLA-DQB1
2	non-distal monosomy 10q	10.7	HLA-DPB1, HLA-DQB1
3	subcorneal pustular dermatosis	10.6	HLA-DPB1, HLA-DQB1
4	dental pulp calcification	10.6	FASLG, GZMB
5	pineal region choriocarcinoma	10.5	FASLG, GZMB
6	somatoform disorder	10.5	ALB, CASR
7	sialolithiasis	10.5	ITGA2, NOTCH1
8	necrotizing gastritis	10.5	CD8A, GZMB
9	ocular muscular dystrophy	10.4	CTGF, HLA-DQB1
10	monkeypox	10.4	CD38, CD8A
11	episodic ataxia	10.4	ALB, CTGF
12	subacute glomerulonephritis	10.3	ALB, CFP, FASLG
13	ossifying fibroma	10.3	ALB, CTGF, HAVCR1
14	autoimmune disease of musculoskeletal system	10.3	CD8A, HLA-DPB1, HLA-DQB1
15	indolent myeloma	10.2	ALB, CD38
16	spondyloarthropathy 1	10.2	CD8A, FASLG, GZMB
17	ulcerative stomatitis	10.2	ALB, CD8A
18	sialadenitis	10.2
19	benign shuddering attacks	10.1	CD38, NOTCH1
20	myositis ossificans	10.1	CD38, CD8A
21	sarcoidosis 1	10.0	GZMB, HLA-DPB1, HLA-DQB1
22	psychotic disorder	10.0	ALB, CTGF, HBA1
23	cell type cancer	9.9	ALB, CD8A, NOTCH1
24	hemangioma	9.9
25	gastrointestinal tuberculosis	9.9	NOTCH1, PRTN3
26	q fever	9.8	FASLG, NOTCH1
27	tenosynovitis of foot and ankle	9.8	ALB, CD8A, ZNF135
28	cystic fibrosis	9.7
29	multiple myeloma	9.7
30	nephrolithiasis	9.7
31	adenoiditis	9.7
32	myeloma	9.7
33	cholelithiasis	9.7
34	salivary gland disease	9.7
35	primary hyperparathyroidism	9.7
36	hyperparathyroidism	9.7
37	down syndrome	9.7
38	cervicitis	9.7
39	epidermolysis bullosa	9.7
40	cavernous hemangioma	9.7
41	pancreatitis	9.7
42	acquired immunodeficiency syndrome	9.7
43	periodontitis	9.7
44	actinomycosis	9.7
45	neuropathy	9.7
46	odontoma	9.7
47	vascular malformation	9.7
48	chronic pain	9.7
49	dysphagia	9.7
50	glycogen storage disease	9.7	ALB, CFP, PRTN3

Comorbidity relations with Sialolithiasis via Phenotypic Disease Network (PDN):

Hypertension, Essential	Sialadenitis

Graphical network of the top 20 diseases related to Sialolithiasis:

Symptoms for Sialolithiasis

Sources:
⁶⁵UMLS
See all MalaCards sources

UMLS symptoms related to Sialolithiasis:

sialectasia nos, salivary gland pain

Drugs & Therapeutics for Sialolithiasis

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶Cochrane Library
See all MalaCards sources

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Sialolithiasis

Cochrane evidence based reviews: salivary gland calculi

Genetic Tests for Sialolithiasis

Anatomical Context for Sialolithiasis

Sources:
³³MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Sialolithiasis:

³³

Salivary gland, Lung, B cells, Pituitary, Heart, Breast, Myeloid

Animal Models for Sialolithiasis or affiliated genes

Sources:
³⁸MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Sialolithiasis:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal	MP:0002873	8.2	ALB, CD8A, CFP, CTGF, FASLG, HLA-DQB1
2	endocrine/exocrine gland	MP:0005379	7.9	ALB, CASR, CD38, CD8A, FASLG, HLA-DQB1
3	cellular	MP:0005384	7.0	ALB, CASR, CD38, CTGF, FASLG, HLA-DQB1
4	hematopoietic system	MP:0005397	6.9	CASR, CD38, CD8A, FASLG, HLA-DQB1, ITGA2
5	homeostasis/metabolism	MP:0005376	6.8	ALB, CASR, CD38, CFP, CTGF, FASLG
6	immune system	MP:0005387	6.7	CASR, CD38, CD8A, CFP, FASLG, HLA-DQB1

Publications for Sialolithiasis

Sources:
⁵⁴PubMed
See all MalaCards sources

Articles related to Sialolithiasis:

(show top 50) (show all 238)

id	Title	Authors	Year
1	Sialolithiasis in horses: A retrospective study of 25 cases (2002-2013). (26663918)	Carlson N.... Winfield L.	2015
2	Endoscopic-assisted gland preserving therapy for the management of parotid gland sialolithiasis: Our preliminary experience. (26293189)	Zheng L.... Yu C.	2015
3	Sialolithiasis: Use tomosynthesis! (25523323)	Lacout A.... Marcy P.Y.	2015
4	Salivary gland diseases: infections, sialolithiasis and mucoceles. (24862601)	Delli K.... Vissink A.	2014
5	Foreign body induced sialolithiasis treated by sialoendoscopic intervention. (25006917)	Xie L.... Kim E.	2014
6	Sialolithiasis. Proposal for a new minimally invasive procedure: Piezoelectric surgery. (25136434)	Pastor-Ramos V.... Aracil-Kessler L.	2014
7	Reliability of sonography in the assessment of sialolithiasis: is the fishnet mesh too small? (24370156)	Loizides A.... Gruber H.	2014
8	What is your diagnosis? Mandibular sialolithiasis. (24548226)	Coutin J.V.... Ellison G.W.	2014
9	An aberrant parotid gland duct with a cutaneous orifice, accompanied by sialolithiasis. (22901859)	Miyashita M.... Kagami H.	2013
10	Sialolithiasis in a 10 year old child. (23257494)	Marwaha M.... Nanda K.D.	2012
11	Etiologic factors in sialolithiasis. (21753035)	Huoh K.C.... Eisele D.W.	2011
12	Complication of adenoid cystic carcinoma and sialolithiasis in the submandibular gland: report of a case and its etiological background. (21159490)	Hasegawa M.... Saku T.	2011
13	Increased calcium and decreased magnesium and citrate concentrations of submandibular/sublingual saliva in sialolithiasis. (19962126)	Su Y.X.... Liao G.Q.	2010
14	Pathogenesis and diverse histologic findings of sialolithiasis in minor salivary glands. (20116725)	Lee L.T.... Wong Y.K.	2010
15	In reference to Lithotripsy for refractory pediatric sialolithiasis (Laryngoscope 2009;119:298-299). (19688849)	Luers J.C.... Beutner D.	2009
16	Sialolithiasis of the submandibular salivary gland treated with the 810- to 830-nm diode laser. (19099383)	Angiero F.... Crippa R.	2008
17	Sublingual salivary gland sialolithiasis in a dog. (18373538)	Ryan T.... Yool D.	2008
18	Tonsilloliths associated with sialolithiasis in the submandibular gland. (18201626)	Suarez-Cunqueiro M.M.... Schmelzeisen R.	2008
19	Parotid duct sialolithiasis in a dog. (17209085)	Trumpatori B.J.... Mathews K.G.	2007
20	First case of sialolithiasis associated with atomoxetine. (17224735)	Jerome L.... Kutcher S.P.	2007
21	Submandibular duct sialolithiasis : an unusual presentation. (17007760)	Shafi M.... Jafferi S.	2006
22	An unusual case of bilateral submandibular sialolithiasis in a young female patient. (15850690)	Waseem Z.... Forte V.	2005
23	Sialolithiasis of submandibular gland. (14980352)	Austin T.... Chan T.	2004
24	Characterization of lymphoid infiltrates in chronic obstructive sialadenitis associated with sialolithiasis. (15078491)	Teymoortash A.... Werner J.A.	2004
25	Endoscopic management of submandibular sialolithiasis. (12618947)	Chu D.W.... Kwok S.P.	2003
26	Sialolithiasis: an unusually large submandibular salivary stone. (12199129)	Siddiqui S.J.	2002
27	Histopathology of submandibular glands removed for sialolithiasis. (11372932)	Marchal F.... Lehmann W.	2001
28	Pediatric sialolithiasis. (11113815)	Nahlieli O.... Baruchin A.M.	2000
29	Symptomatic sialoadenitis and sialolithiasis in the English population, an estimate of the cost of hospital treatment. (10365495)	Escudier M.P.... McGurk M.	1999
30	The management of sialolithiasis in 2 children through use of extracorporeal shock wave lithotripsy. (10442944)	Escudier M.P.... Drage N.A.	1999
31	Laser lithotripsy: a preliminary study on its application for sialolithiasis. (7947565)	McGurk M.... King T.A.	1994
32	Angiolithiasis and sialolithiasis in the head and neck. (1570941)	Raymond A.K.... Batsakis J.G.	1992
33	An uncommon case of parotid sialolithiasis. (1872587)	Wells M.D.... McClatchey K.D.	1991
34	Submandibular sialolithiasis: transoral excision. (2593220)	Novotny G.M.	1989
35	Effects of experimentally-induced sialolithiasis on the composition of rat submandibular saliva. (3465945)	Yoshida Y.... Kakudo Y.	1986
36	Submandibular sialolithiasis in children. (6955470)	Bodner L.... Azaz B.	1982
37	Sialolithiasis: the radiolucent ones. (1059067)	Langlais R.P.... Kasle M.J.	1975
38	Sialolithiasis and sialoadenitis of a minor salivary gland: report of case. (4503105)	Knight W.O.	1972
39	Sialolithiasis of accessory salivary glands: review of 55 cases. (4507238)	Pullon P.A.... Miller A.S.	1972
40	Sialolithiasis of a minor salivary gland. A case report and review of the literature. (5264862)	Hobkirk J.A.	1970
41	Sialolithiasis and enlarged genial tubercles. (5272046)	Wiesenbaugh J.M.... Bingham C.	1970
42	Sialolithiasis of the minor salivary glands: report of three cases. (5238931)	Holst E.	1968
43	Sialolithiasis--diagnosis and treatment. (5237062)	Seldin H.M.	1967
44	MINOR SALIVARY GLAND SIALOLITHIASIS. REPORT OF A CASE. (14117364)	MOSKOW R.... Robinson H.L.	1964
45	Sialographic studies on submandibular sialolithiasis. (13946669)	GARUSI G.F.... SASSI P.	1963
46	Sialolithiasis of a minor salivary gland. (13809470)	CHAUDHRY A.P.... REYNOLDS D.H.	1960
47	Studies in sialolithiasis. I. The structure and mineralogical composition of salivary gland calculi. (13583890)	BLATT I.M.... MAXWELL J.H.	1958
48	Studies in sialolithiasis. II. Uric acid calculus of the parotid gland; report of a case. (13606697)	BLATT I.M.... DENNING R.M.	1958
49	Sialolithiasis, Wharton's duct, left submaxillary gland; report of a case. (13297388)	ORLEAN S.L.	1956
50	Sialolithiasis. (18873404)	BOURGOYNE J.R.	1948

Genes related to Sialolithiasis

Sources:
²⁰GeneCards, ¹²DISEASES
See all MalaCards sources

Genes related to Sialolithiasis:

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	ACBD6	Acyl-CoA Binding Domain Containing 6	17.95	DISEASES inferred ¹²
2	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	15.72	DISEASES inferred ¹²
3	HAVCR1	Hepatitis A Virus Cellular Receptor 1	14.94	DISEASES inferred ¹²
4	CFP	Complement Factor Properdin	14.93	DISEASES inferred ¹²
5	HLA-DPB1	Major Histocompatibility Complex, Class II, DP Beta 1	14.60	DISEASES inferred ¹²
6	TIMP3	TIMP Metallopeptidase Inhibitor 3	14.52	DISEASES inferred ¹²
7	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	14.29	DISEASES inferred ¹²
8	GZMB	Granzyme B	14.24	DISEASES inferred ¹²
9	CASR	Calcium Sensing Receptor	14.24	DISEASES inferred ¹²
10	ITGA2	Integrin Subunit Alpha 2	14.21	DISEASES inferred ¹²
11	CTGF	Connective Tissue Growth Factor	14.14	DISEASES inferred ¹²
12	FASLG	Fas Ligand	13.95	DISEASES inferred ¹²
13	CD38	CD38 Molecule	13.93	DISEASES inferred ¹²
14	ALB	Albumin	13.89	DISEASES inferred ¹²
15	NOTCH1	Notch 1	13.66	DISEASES inferred ¹²
16	CD8A	CD8a Molecule	13.64	DISEASES inferred ¹²
17	HBA1	Hemoglobin Subunit Alpha 1	13.44	DISEASES inferred ¹²
18	ZNF135	Zinc Finger Protein 135	4.13	DISEASES inferred ¹²
19	PRTN3	Proteinase 3	3.95	DISEASES inferred ¹²
20	MGAM	Maltase-Glucoamylase	3.84	DISEASES inferred ¹²

Variations for Sialolithiasis

Expression for genes affiliated with Sialolithiasis

Sources:
¹⁷Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Sialolithiasis.

Pathways for genes affiliated with Sialolithiasis

Sources:
⁵²PathCards, ³⁹NCBI BioSystems Database, ⁶²Thomson Reuters, ³¹KEGG, ⁵⁵QIAGEN, ⁵⁶R&D Systems
See all MalaCards sources

Pathways related to Sialolithiasis according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Downstream signaling in naive CD8+ T cells³⁹ Show member pathways Ras signaling in the CD4+ TCR pathway³⁹	9.4	CD8A, FASLG, GZMB
2	IL12-mediated signaling events³⁹ Show member pathways Immune response IL-12-induced IFN-gamma production⁶²	9.4	CD8A, FASLG, GZMB
3	Hematopoietic cell lineage³¹	9.4	CD38, CD8A, ITGA2
4	Allograft rejection³⁹ ³¹ Show member pathways Antigen processing and presentation³¹ Viral myocarditis³¹ Intestinal immune network for IgA production³¹ CTL Mediated Apoptosis⁵⁵ THC Differentiation Pathway⁵⁵ Allograft Rejection³⁹ Asthma³¹ Autoimmune thyroid disease³¹ Type I diabetes mellitus³¹ Graft-versus-host disease³¹ Inflammatory bowel disease (IBD)³¹	9.0	CD8A, FASLG, GZMB, HLA-DPB1, HLA-DQB1
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁶	9.0	CD38, CD8A, ITGA2, NOTCH1

GO Terms for genes affiliated with Sialolithiasis

Sources:
¹⁸Gene Ontology
See all MalaCards sources

Cellular components related to Sialolithiasis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:0042613	10.1	HLA-DPB1, HLA-DQB1
2	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	10.0	HLA-DPB1, HLA-DQB1

Biological processes related to Sialolithiasis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	antigen processing and presentation	GO:0019882	10.3	HLA-DPB1, HLA-DQB1
2	response to organic cyclic compound	GO:0014070	9.6	CASR, CTGF, ITGA2
3	branching morphogenesis of an epithelial tube	GO:0048754	9.5	CASR, NOTCH1