MCID: SLL001
MIFTS: 41

Sialolithiasis

Categories: Gastrointestinal diseases, Endocrine diseases, Oral diseases

Aliases & Classifications for Sialolithiasis

MalaCards integrated aliases for Sialolithiasis:

Name: Sialolithiasis 12 14 69
Stone of Salivary Gland or Duct 12
Salivary Gland Calculi 41
Salivary Gland Stone 12
Sialolith 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12905
ICD10 32 K11.5
ICD9CM 34 527.5
MeSH 41 D015494
NCIt 46 C34994
UMLS 69 C0036091

Summaries for Sialolithiasis

MalaCards based summary : Sialolithiasis, also known as stone of salivary gland or duct, is related to salivary duct calculi and breast medullary carcinoma. An important gene associated with Sialolithiasis is TRPC3 (Transient Receptor Potential Cation Channel Subfamily C Member 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Wnt / Hedgehog / Notch. Affiliated tissues include salivary gland, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 72 Sialolithiasis (also termed salivary calculi, or salivary stones), is a condition where a calcified mass... more...

Related Diseases for Sialolithiasis

Diseases related to Sialolithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 salivary duct calculi 11.0
2 breast medullary carcinoma 10.3 FASLG GZMB
3 lymphocytic gastritis 10.2 FASLG GZMB
4 sialadenitis 10.2
5 benign essential hypertension 10.2 ALB MGAM
6 b-cell expansion with nfkb and t-cell anergy 10.1 CD38 FASLG GZMB
7 tympanic membrane disease 10.1 NOTCH1 SPP1
8 kidney hypertrophy 10.0 ALB CTGF
9 uremia 10.0 AHSG ALB CASR SPP1
10 episodic pain syndrome, familial, 1 10.0
11 cholecystolithiasis 9.9 CTGF TGFB1
12 type 1 diabetes mellitus 11 9.9 HBA1 NOTCH1
13 nephrogenic systemic fibrosis 9.9 CTGF SPP1 TGFB1
14 hepatitis a 9.9 ALB HAVCR1 TGFB1
15 granulomatous gastritis 9.9 NOTCH1 PRTN3 SPP1
16 microvascular complications of diabetes 3 9.9 ALB CTGF TGFB1
17 hemangioma 9.9
18 primary hyperparathyroidism 9.9
19 hyperparathyroidism 9.9
20 cervicitis 9.9
21 iga glomerulonephritis 9.9 ALB CFP TGFB1
22 urinary tract obstruction 9.8 ALB CTGF TGFB1
23 retinal vascular disease 9.8 ALB CTGF HBA1 LRP5
24 aortic valve disease 1 9.7 NOTCH1 SPP1 TGFB1
25 urinary system disease 9.7 ALB CTGF HAVCR1 TGFB1
26 pilomatrixoma 9.7
27 fibrosis of extraocular muscles, congenital, 1 9.7
28 down syndrome 9.7
29 cystic fibrosis 9.7
30 myeloma, multiple 9.7
31 aging 9.7
32 horns in sheep 9.7
33 nephrolithiasis 9.7
34 adenoiditis 9.7
35 cholelithiasis 9.7
36 parotitis 9.7
37 salivary gland disease 9.7
38 epidermolysis bullosa 9.7
39 cavernous hemangioma 9.7
40 pancreatitis 9.7
41 acquired immunodeficiency syndrome 9.7
42 periodontitis 9.7
43 actinomycosis 9.7
44 neuropathy 9.7
45 odontoma 9.7
46 chronic pain 9.7
47 dysphagia 9.7
48 stiff skin syndrome 9.7 CTGF TGFB1
49 biliary atresia 9.7 ALB CTGF SPP1 TGFB1
50 pulmonary fibrosis, idiopathic 9.6 CTGF FASLG SPP1 TGFB1

Comorbidity relations with Sialolithiasis via Phenotypic Disease Network (PDN):


Hypertension, Essential Sialadenitis

Graphical network of the top 20 diseases related to Sialolithiasis:



Diseases related to Sialolithiasis

Symptoms & Phenotypes for Sialolithiasis

MGI Mouse Phenotypes related to Sialolithiasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 TGFB1 TIMP3 ALB CASR CD38 CTGF
2 homeostasis/metabolism MP:0005376 10.22 CTGF FASLG LRP5 MGAM NOTCH1 SPP1
3 immune system MP:0005387 10.15 CASR CD38 CFP FASLG LRP5 NOTCH1
4 hematopoietic system MP:0005397 10.13 CASR CD38 FASLG LRP5 NOTCH1 PRTN3
5 endocrine/exocrine gland MP:0005379 10.11 ALB CASR CD38 CTGF FASLG LRP5
6 liver/biliary system MP:0005370 9.92 ALB CTGF FASLG LRP5 NOTCH1 SPP1
7 muscle MP:0005369 9.8 AHSG ALB CASR NOTCH1 SPP1 TGFB1
8 renal/urinary system MP:0005367 9.7 ALB CASR FASLG NOTCH1 SPP1 TGFB1
9 skeleton MP:0005390 9.61 AHSG CASR CFP CTGF FASLG LRP5
10 vision/eye MP:0005391 9.23 TGFB1 TIMP3 TRPC3 FASLG LRP5 NOTCH1

Drugs & Therapeutics for Sialolithiasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Association Between Nephrolithiasis and Periodontal Status Not yet recruiting NCT03102086

Search NIH Clinical Center for Sialolithiasis

Cochrane evidence based reviews: salivary gland calculi

Genetic Tests for Sialolithiasis

Anatomical Context for Sialolithiasis

MalaCards organs/tissues related to Sialolithiasis:

38
Salivary Gland

Publications for Sialolithiasis

Articles related to Sialolithiasis:

(show top 50) (show all 269)
# Title Authors Year
1
Sialendoscopy in treatment of adult chronic recurrent parotitis without sialolithiasis. ( 29290052 )
2018
2
Sialendoscopy for sialolithiasis in children: 4-8 years follow up. ( 29373144 )
2018
3
Multimodal treatment in difficult sialolithiasis: Role of extracorporeal shock-wave lithotripsy and intraductal pneumatic lithotripsy. ( 29243260 )
2017
4
Pediatric sialolithiasis is not related to oral or oropharyngeal infection: A population-based case control study using the Korean National Health Insurance Database. ( 28483226 )
2017
5
Accuracy of Ultrasonography and Computed Tomography in the Evaluation of Patients Undergoing Sialendoscopy for Sialolithiasis. ( 28457224 )
2017
6
Cervical fistula caused by submandibular sialolithiasis. ( 29071060 )
2017
7
The Role of Fetuin-A and Electrolytes in the Etiology of Sialolithiasis. ( 28457217 )
2017
8
Sialolithiasis of an Accessory Parotid Gland Causing Mid-Cheek Pain. ( 28468191 )
2017
9
Transoral submandibulotomy for deep hilar submandibular gland sialolithiasis. ( 28052363 )
2017
10
The landmark for removal of sialoliths using sialendoscopy alone in parotid gland sialolithiasis. ( 28651858 )
2017
11
Sialolithiasis Of Lower Lip - Histopathological Interpretation. ( 29076701 )
2017
12
Idiopathic Sialolithiasis: Scalpel Versus Current Trends in Management. ( 28358758 )
2017
13
Treatment outcomes of sialendoscopy for submandibular gland sialolithiasis: The minor axis of the sialolith is a regulative factor for the removal of sialoliths in the hilum of the submandibular gland using sialendoscopy alone. ( 28935124 )
2017
14
Value of Sonography in the Diagnosis of Sialolithiasis: Comparison With the Reference Standard of Direct Stone Identification. ( 28556090 )
2017
15
Sialolithiasis removal under general anesthesia: A descriptive retrospective study in the maxillofacial surgery department in Lille University Hospital. ( 29129709 )
2017
16
The value of the twinkling artefact for the diagnosis of sialolithiasis of the large salivary glands. ( 29248029 )
2017
17
The Diagnostic Accuracy of Contrast-Enhanced CT of the Neck for the Investigation of Sialolithiasis. ( 28838906 )
2017
18
Unilateral Submandibular Gland Atrophy and Sialolithiasis Diagnosed on 99mTc-MIBI SPECT/CT in a Patient With Primary Hyperparathyroidism. ( 29036000 )
2017
19
Submandibular sialolithiasis with CT and scintigraphy: CT values and salivary gland excretion in the submandibular glands. ( 29279821 )
2017
20
Comparison between Sialendoscopy and Conventional Methods in the Treatment of Sialolithiasis. ( 29386976 )
2017
21
Chronic sialadenitis with sialolithiasis associated with parapharyngeal fistula and tonsillolith. ( 28828116 )
2017
22
Sialolithiasis of an Accessory Parotid Gland Causing Mid-Cheek Pain. ( 28114210 )
2017
23
Recurrent sialoliths after excision of the bilateral submandibular glands for sialolithiasis treatment: A case report. ( 26889264 )
2016
24
Does saliva composition affect the formation of sialolithiasis? ( 27974066 )
2016
25
Sialolithiasis is associated with nephrolithiasis: a case-control study. ( 26808906 )
2016
26
Sialendoscopy for Sublingual Gland Sialolithiasis. ( 28056531 )
2016
27
Incidence of sialolithiasis in Denmark: a nationwide population-based register study. ( 28005152 )
2016
28
A population-based study on the association between chronic periodontitis and sialolithiasis. ( 26808379 )
2016
29
Sialolithiasis in an Accessory Submandibular Gland Identified by Magnetic Resonance Sialography. ( 26961009 )
2016
30
Rapid recurrent sialolithiasis: Altered stone composition and potential factors for recurrence. ( 27753112 )
2016
31
Canine Sialolithiasis: Two Case Reports with Breed, Gender, and Age Distribution of 29 Cases (1964-2010). ( 26606211 )
2016
32
A Hard Calculus: Submandibular Sialolithiasis. ( 27742262 )
2016
33
A Case of Sialolithiasis in a Minor Salivary Gland of the Buccal Mucosa. ( 28050512 )
2016
34
Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy-assisted salivary duct surgery. ( 27701754 )
2016
35
Possible Drug-Associated Sialolithiasis From the Bicarbonate Anhydrase Inhibitor Topiramate: A Case Report and Literature Review. ( 27292524 )
2016
36
Parotid cyst due to sialolithiasis masquerading as pilomatrixoma on FNA. ( 27943427 )
2016
37
Does drinking water influence hospital-admitted sialolithiasis on an epidemiological level in Denmark? ( 25941183 )
2015
38
Endoscopic-assisted gland preserving therapy for the management of parotid gland sialolithiasis: Our preliminary experience. ( 26293189 )
2015
39
Sialolithiasis: Use tomosynthesis! ( 25523323 )
2015
40
Clinicopathological aspects of 25 cases of sialolithiasis of minor salivary glands. ( 25945774 )
2015
41
Unusual form of sialolithiasis: case report with 3-dimensional imaging. ( 26530733 )
2015
42
Sialadenitis Without Sialolithiasis Treated by Sialendoscopy. ( 25863231 )
2015
43
Sialolithiasis in horses: A retrospective study of 25 cases (2002-2013). ( 26663918 )
2015
44
Sialolithiasis of an accessory parotid gland: an unusual case. ( 26048098 )
2015
45
Combined approach sialendoscopy for management of submandibular gland sialolithiasis. ( 26052045 )
2015
46
Objective and subjective outcome in 42 patients after treatment of sialolithiasis by transoral incision of Warthon's duct: a retrospective middle-term follow-up study. ( 24493562 )
2014
47
Reliability of sonography in the assessment of sialolithiasis: is the fishnet mesh too small? ( 24370156 )
2014
48
Comparative analysis of sialendoscopy, sonography, and CBCT in the detection of sialolithiasis. ( 25345873 )
2014
49
Submandibular venous malformation phleboliths mimicking sialolithiasis in children. ( 24986521 )
2014
50
Sialolithiasis. Proposal for a new minimally invasive procedure: Piezoelectric surgery. ( 25136434 )
2014

Variations for Sialolithiasis

Expression for Sialolithiasis

Search GEO for disease gene expression data for Sialolithiasis.

Pathways for Sialolithiasis

GO Terms for Sialolithiasis

Cellular components related to Sialolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.83 CASR CD38 FASLG NOTCH1 TGFB1
2 extracellular region GO:0005576 9.73 AHSG ALB CFP CTGF FASLG HBA1
3 endoplasmic reticulum lumen GO:0005788 9.71 AHSG ALB CFP SPP1
4 blood microparticle GO:0072562 9.56 AHSG ALB HBA1 TGFB1
5 extracellular matrix GO:0031012 9.55 AHSG CFP PRTN3 TGFB1 TIMP3
6 platelet alpha granule lumen GO:0031093 9.5 AHSG ALB TGFB1
7 extracellular space GO:0005615 9.36 AHSG ALB CFP CTGF FASLG HBA1
8 extracellular exosome GO:0070062 10.07 AHSG ALB CD38 FASLG HBA1 MGAM

Biological processes related to Sialolithiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.8 CD38 LRP5 NOTCH1 SPP1 TGFB1
2 response to estradiol GO:0032355 9.54 CD38 CTGF TGFB1
3 response to organic substance GO:0010033 9.5 SPP1 TGFB1 TIMP3
4 ossification GO:0001503 9.43 AHSG CASR CTGF
5 platelet degranulation GO:0002576 9.26 AHSG ALB TGFB1 TIMP3
6 positive regulation of cell proliferation GO:0008284 9.17 CASR CTGF FASLG LRP5 NOTCH1 PRTN3
7 negative regulation of phagocytosis GO:0050765 9.16 PRTN3 TGFB1

Sources for Sialolithiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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