Sialolithiasis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Wikipedia:⁷¹ Sialolithiasis (also termed salivary calculi, or salivary stones), is a condition where a calcified mass... more...

MalaCards based summary: Sialolithiasis, also known as stone of salivary gland or duct, is related to sialadenitis and hypertension, essential. An important gene associated with Sialolithiasis is TRPC3 (Transient Receptor Potential Cation Channel Subfamily C Member 3), and among its related pathways are Ion channel transport and Platelet homeostasis. Affiliated tissues include salivary gland.

Related Diseases for Sialolithiasis

Sources:
²⁰GeneAnalytics, ²¹GeneCards, ⁶⁸UMLS
See all MalaCards sources

Diseases related to Sialolithiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)

id	Related Disease	Score	Top Affiliating Genes
1	sialadenitis	10.1
2	hypertension, essential	10.0	TRPC3, XK
3	angiokeratoma	9.8	CFP, XK
4	hemangioma	9.8
5	cystic fibrosis	9.6
6	multiple myeloma	9.6
7	nephrolithiasis	9.6
8	adenoiditis	9.6
9	cholelithiasis	9.6
10	salivary gland disease	9.6
11	hyperparathyroidism	9.6
12	down syndrome	9.6
13	cervicitis	9.6
14	epidermolysis bullosa	9.6
15	cavernous hemangioma	9.6
16	pancreatitis	9.6
17	acquired immunodeficiency syndrome	9.6
18	periodontitis	9.6
19	actinomycosis	9.6
20	neuropathy	9.6
21	odontoma	9.6
22	vascular malformation	9.6
23	chronic pain	9.6
24	dysphagia	9.6
25	screw worm infectious disease	9.2	ATP2B3, CFP, HAVCR1, TRPC3, XK

Comorbidity relations with Sialolithiasis via Phenotypic Disease Network (PDN):

Hypertension, Essential	Sialadenitis

Graphical network of the top 20 diseases related to Sialolithiasis:

Symptoms & Phenotypes for Sialolithiasis

Drugs & Therapeutics for Sialolithiasis

Sources:
⁴ClinicalTrials, ⁷Cochrane Library
See all MalaCards sources

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	The Association Between Nephrolithiasis and Periodontal Status	Not yet recruiting	NCT03102086

Search NIH Clinical Center for Sialolithiasis

Cochrane evidence based reviews: salivary gland calculi

Genetic Tests for Sialolithiasis

Anatomical Context for Sialolithiasis

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Sialolithiasis:

³⁶

Salivary gland

Publications for Sialolithiasis

Sources:
⁵⁷PubMed
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Articles related to Sialolithiasis:

(show top 50) (show all 248)

id	Title	Authors	Year
1	Transoral submandibulotomy for deep hilar submandibular gland sialolithiasis. (28052363)	Schapher M.... Koch M.	2017
2	Rapid recurrent sialolithiasis: Altered stone composition and potential factors for recurrence. (27753112)	Trujillo O.... Rahmati R.	2016
3	Sialendoscopy for Sublingual Gland Sialolithiasis. (28056531)	Goodstein L.... Cognetti D.	2016
4	Possible Drug-Associated Sialolithiasis From the Bicarbonate Anhydrase Inhibitor Topiramate: A Case Report and Literature Review. (27292524)	Buhler A.V.... Von M.	2016
5	Sialolithiasis is associated with nephrolithiasis: a case-control study. (26808906)	Wu C.C.... Chung S.D.	2016
6	Parotid cyst due to sialolithiasis masquerading as pilomatrixoma on FNA. (27943427)	Galed-Placed I.... Veiga-Barreiro A.	2016
7	Sialolithiasis in an Accessory Submandibular Gland Identified by Magnetic Resonance Sialography. (26961009)	Sanchez Barrueco A.... Cenjor EspaA+ol C.	2016
8	A Hard Calculus: Submandibular Sialolithiasis. (27742262)	Bakshi S.S.	2016
9	A Case of Sialolithiasis in a Minor Salivary Gland of the Buccal Mucosa. (28050512)	Kimura M.... Umemura M.	2016
10	Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy-assisted salivary duct surgery. (27701754)	Delagnes E.A.... Ryan W.R.	2016
11	A population-based study on the association between chronic periodontitis and sialolithiasis. (26808379)	Hung S.H.... Wu C.S.	2016
12	Recurrent sialoliths after excision of the bilateral submandibular glands for sialolithiasis treatment: A case report. (26889264)	Ying X.... Dong H.	2016
13	Incidence of sialolithiasis in Denmark: a nationwide population-based register study. (28005152)	SchrA... e P.	2016
14	Canine Sialolithiasis: Two Case Reports with Breed, Gender, and Age Distribution of 29 Cases (1964-2010). (26606211)	Han H.... Park J.Y.	2016
15	Does saliva composition affect the formation of sialolithiasis? (27974066)	SchrA... Bardow A.	2016
16	Does drinking water influence hospital-admitted sialolithiasis on an epidemiological level in Denmark? (25941183)	SchrA... Bardow A.	2015
17	Clinicopathological aspects of 25 cases of sialolithiasis of minor salivary glands. (25945774)	Brazao-Silva M.T.... de Sousa S.O.	2015
18	Sialolithiasis in horses: A retrospective study of 25 cases (2002-2013). (26663918)	Carlson N.... Winfield L.	2015
19	Unusual form of sialolithiasis: case report with 3-dimensional imaging. (26530733)	NAcmeth B.... Pataky L.	2015
20	Endoscopic-assisted gland preserving therapy for the management of parotid gland sialolithiasis: Our preliminary experience. (26293189)	Zheng L.... Yu C.	2015
21	Sialolithiasis of an accessory parotid gland: an unusual case. (26048098)	Debnath S.C.... Adhyapok A.K.	2015
22	Sialolithiasis: Use tomosynthesis! (25523323)	Lacout A.... Marcy P.Y.	2015
23	Combined approach sialendoscopy for management of submandibular gland sialolithiasis. (26052045)	Schwartz N.... Goshen S.	2015
24	Sialadenitis Without Sialolithiasis Treated by Sialendoscopy. (25863231)	Pace C.G.... Troulis M.J.	2015
25	Foreign body induced sialolithiasis treated by sialoendoscopic intervention. (25006917)	Xie L.... Kim E.	2014
26	Bedside emergency ultrasound in a case of acute parotid duct sialolithiasis. (24877763)	Oliveira L.G.... Magajna P.W.	2014
27	Sialolithiasis. Proposal for a new minimally invasive procedure: Piezoelectric surgery. (25136434)	Pastor-Ramos V.... Aracil-Kessler L.	2014
28	Multiple bilateral submandibular gland sialolithiasis. (24326820)	Sunder V.S.... Mahoorkar S.	2014
29	What is your diagnosis? Mandibular sialolithiasis. (24548226)	Coutin J.V.... Ellison G.W.	2014
30	The Association of Sialolithiasis with Cholelithiasis: A Population-Based Study. (25482495)	Hung S.H.... Chung S.D.	2014
31	Submandibular hemangioma with multiple phleboliths mimicking sialolithiasis: the first pediatric case. (25010807)	AynalA+ G.... YA+lmaz O.	2014
32	Zygomatic sialolithiasis diagnosed with computed tomography in a dog. (24942114)	Lee N.... Yoon J.	2014
33	Objective and subjective outcome in 42 patients after treatment of sialolithiasis by transoral incision of Warthon's duct: a retrospective middle-term follow-up study. (24493562)	Juul M.L.... Wagner N.	2014
34	Learning Progression in the Use of Sialendoscopy for Sialolithiasis: Effect on Gland Preservation. (24812078)	Modest M.C.... Cognetti D.M.	2014
35	Minimally invasive surgery of sialolithiasis using sialendoscopy. (24970706)	Matsunobu T.... Shiotani A.	2014
36	Outcomes of Holmium Laser-Assisted Lithotripsy with Sialendoscopy in Treatment of Sialolithiasis. (24598407)	Phillips J.... Withrow K.	2014
37	Reliability of sonography in the assessment of sialolithiasis: is the fishnet mesh too small? (24370156)	Loizides A.... Gruber H.	2014
38	Long-term results of combined approach in parotid sialolithiasis. (25388993)	Konstantinidis I.... Constantinidis J.	2014
39	Submandibular venous malformation phleboliths mimicking sialolithiasis in children. (24986521)	Gooi Z.... Eisele D.W.	2014
40	Scintigraphic detection of a parotid salivary gland malfunction, in chronic sialolithiasis and fat infiltration with no risk factors. (24563881)	Konstantinidis I.... Iakovou I.	2014
41	Salivary gland diseases: infections, sialolithiasis and mucoceles. (24862601)	Delli K.... Vissink A.	2014
42	Comparative analysis of sialendoscopy, sonography, and CBCT in the detection of sialolithiasis. (25345873)	Schwarz D.... Luers J.C.	2014
43	Algorithm changes in treatment of submandibular gland sialolithiasis. (23568038)	KopeA8 T.... LeszczyA8ska M.	2013
44	An aberrant parotid gland duct with a cutaneous orifice, accompanied by sialolithiasis. (22901859)	Miyashita M.... Kagami H.	2013
45	Submandibular sialolithiasis in a child. (23378557)	Liu N.M.... Rawal J.	2013
46	Deep and unusual sialolithiasis of submandibular duct and gland: a surgical dilemma. (24427589)	Hazarika P.... Arora S.	2013
47	Ho:Yag laser for sialolithiasis of Wharton's duct. (23462654)	Martellucci S.... Gallo A.	2013
48	Submandibular sialolithiasis: Report of six cases. (24082702)	Kuruvila V.E.... James B.	2013
49	Minor salivary gland sialolithiasis of the upper lip. (24371404)	Suh D.W.... Sim W.Y.	2013
50	Combined endoscopic-transcutaneous surgery in parotid gland sialolithiasis and other ductal diseases: reporting medium- to long-term objective and patients' subjective outcomes. (23224766)	Koch M.... Zenk J.	2013

Genes related to Sialolithiasis

Sources:
¹³DISEASES, ²¹GeneCards
See all MalaCards sources

Genes related to Sialolithiasis:

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	23.43	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
2	ATP2B3	ATPase Plasma Membrane Ca2+ Transporting 3	23.00	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
3	CFP	Complement Factor Properdin	22.85	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
4	HAVCR1	Hepatitis A Virus Cellular Receptor 1	22.69	DISEASES inferred ¹³ GeneCards inferred via : Disorders (show sections)
5	XK	X-Linked Kx Blood Group	18.12	GeneCards inferred via : Disorders (show sections)

Variations for Sialolithiasis

Expression for genes affiliated with Sialolithiasis

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Sialolithiasis.

Pathways for genes affiliated with Sialolithiasis

Sources:
⁵⁵PathCards, ⁶⁰Reactome
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Pathways related to Sialolithiasis according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	Ion channel transport⁶⁰ Show member pathways Stimuli-sensing channels⁶⁰	9.5	ATP2B3, TRPC3
2	Platelet homeostasis⁶⁰ Show member pathways Platelet sensitization by LDL⁶⁰ Prostacyclin signalling through prostacyclin receptor⁶⁰ Elevation of cytosolic Ca2+ levels⁶⁰ Platelet calcium homeostasis⁶⁰ Reduction of cytosolic Ca++ levels⁶⁰	9.5	ATP2B3, TRPC3

GO Terms for genes affiliated with Sialolithiasis

Sources:
¹⁹Gene Ontology
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Biological processes related to Sialolithiasis according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	calcium ion transmembrane transport	GO:0070588	10.1	ATP2B3, TRPC3
2	calcium ion transport	GO:0006816	10.0	ATP2B3, TRPC3
3	cellular calcium ion homeostasis	GO:0006874	9.4	ATP2B3, XK