MCID: SCK001
MIFTS: 38

Sick Building Syndrome malady

Categories: Respiratory diseases

Aliases & Classifications for Sick Building Syndrome

Aliases & Descriptions for Sick Building Syndrome:

Name: Sick Building Syndrome 12 3 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2710
MeSH 42 D018877
SNOMED-CT 64 19076009
UMLS 69 C0037050

Summaries for Sick Building Syndrome

CDC : 3 Indoor environmental quality (IEQ) refers to the quality of a building’s environment in relation to the health and wellbeing of those who occupy space within it. IEQ is determined by many factors, including lighting, air quality, and damp conditions. Workers are often concerned that they have symptoms or health conditions from exposures to contaminants in the buildings where they work. One reason for this concern is that their symptoms often get better when they are not in the building. While research has shown that some respiratory symptoms and illnesses can be associated with damp buildings, it is still unclear what measurements of indoor contaminants show that workers are at risk for disease. In most instances where a worker and his or her physician suspect that the building environment is causing a specific health condition, the information available from medical tests and tests of the environment is not sufficient to establish which contaminants are responsible. Despite uncertainty about what to measure and how to interpret what is measured, research shows that building-related symptoms are associated with building characteristics, including dampness, cleanliness, and ventilation characteristics.

MalaCards based summary : Sick Building Syndrome is related to cleft lip palate-tetraphocomelia and neurogenic arthropathy. An important gene associated with Sick Building Syndrome is PNPLA6 (Patatin Like Phospholipase Domain Containing 6), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Bladder cancer. The drugs Dopamine and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and behavior/neurological

Disease Ontology : 12 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

Wikipedia : 71 Sick building syndrome (SBS) a medical condition where people in a building suffer from symptoms of... more...

Related Diseases for Sick Building Syndrome

Diseases related to Sick Building Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
id Related Disease Score Top Affiliating Genes
1 cleft lip palate-tetraphocomelia 10.1 LEP POMC
2 neurogenic arthropathy 10.1 LEP POMC
3 second-degree atrioventricular block 10.1 LEP POMC
4 kidney osteogenic sarcoma 10.1 MMP9 VEGFA
5 senile atrophy of choroid 10.1 MMP9 VEGFA
6 large cell medulloblastoma 10.1 MMP9 VEGFA
7 rheumatic encephalitis 10.1 POMC VEGFA
8 adult neuronal ceroid lipofuscinosis 10.1 MMP9 VEGFA
9 suppurative periapical periodontitis 10.1 POMC VEGFA
10 maxillary neoplasm 10.1 MMP9 VEGFA
11 onychocytic matricoma 10.1 MMP9 VEGFA
12 acute gonococcal salpingitis 10.1 LEP POMC
13 leukoplakia of vagina 10.1 MMP9 VEGFA
14 chondroma 10.0 LEP POMC
15 pituitary infarct 10.0 MMP9 VEGFA
16 epidermolysis bullosa simplex, sutosomal recessive 2 10.0 MMP9 VEGFA
17 vulvitis 10.0 LEP VEGFA
18 marginal zone b-cell lymphoma 10.0 MMP9 VEGFA
19 histiocytoid hemangioma 9.9 MMP9 VEGFA
20 neuropathy, hereditary sensory, type ib 9.9 MMP9 VEGFA
21 multiple chemical sensitivity 9.9
22 chronic fatigue syndrome 9.9
23 atopy 9.9
24 spondylolysis 9.9 POMC VEGFA
25 cholesteatoma 9.9 LEP POMC
26 exophthalmic ophthalmoplegia 9.9 LEP MMP9 VEGFA
27 chronic tic disorder 9.9 LEP MMP9 VEGFA
28 pyrimidine metabolic disorder 9.9 LRP6 MMP9 VEGFA
29 sinusitis 9.8
30 plague 9.8
31 rhinitis 9.8
32 neuropathy 9.8
33 stachybotrys chartarum 9.8
34 endotheliitis 9.8
35 asthma 9.8
36 hepatic vascular disease 9.1 ITM2B LEP LRP6 MMP9 PNPLA6 POMC

Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to Sick Building Syndrome

Symptoms & Phenotypes for Sick Building Syndrome

GenomeRNAi Phenotypes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.53 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.53 POMC LRP6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 LEP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.53 LEP LRP6 POMC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.53 LRP6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.53 LRP6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.53 LEP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.53 POMC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.53 POMC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.53 LRP6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.53 LRP6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.53 POMC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.53 POMC

MGI Mouse Phenotypes related to Sick Building Syndrome:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.04 ITM2B LEP LRP6 MMP9 PNPLA6 POMC
2 cellular MP:0005384 9.93 LEP LRP6 MMP9 PNPLA6 POMC VEGFA
3 growth/size/body region MP:0005378 9.91 LEP LRP6 MMP9 PNPLA6 POMC VEGFA
4 cardiovascular system MP:0005385 9.88 LEP MMP9 PNPLA6 POMC VEGFA
5 homeostasis/metabolism MP:0005376 9.88 LEP LRP6 MMP9 PNPLA6 POMC VEGFA
6 integument MP:0010771 9.85 POMC VEGFA LEP LRP6 MMP9 PNPLA6
7 limbs/digits/tail MP:0005371 9.62 LEP LRP6 MMP9 VEGFA
8 liver/biliary system MP:0005370 9.56 LRP6 POMC VEGFA LEP
9 nervous system MP:0003631 9.5 ITM2B LEP LRP6 MMP9 PNPLA6 POMC
10 neoplasm MP:0002006 9.46 LEP MMP9 POMC VEGFA
11 renal/urinary system MP:0005367 9.02 LEP LRP6 MMP9 POMC VEGFA

Drugs & Therapeutics for Sick Building Syndrome

Drugs for Sick Building Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
2 Adrenergic Agents Phase 3
3 Adrenergic alpha-Antagonists Phase 3
4 Adrenergic Antagonists Phase 3
5 Antipsychotic Agents Phase 3
6 Central Nervous System Depressants Phase 3
7 Dopamine Agents Phase 3
8 Dopamine Antagonists Phase 3
9 Dopamine D2 Receptor Antagonists Phase 3
10
Lurasidone hydrochloride Phase 3 367514-87-2 213046
11 Neurotransmitter Agents Phase 3
12 Psychotropic Drugs Phase 3
13
Serotonin Phase 3 50-67-9 5202
14 Serotonin 5-HT2 Receptor Antagonists Phase 3
15 Serotonin Agents Phase 3
16 Serotonin Antagonists Phase 3
17 Tranquilizing Agents Phase 3
18
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
19
Lenograstim Approved Phase 1 135968-09-1
20 Adjuvants, Immunologic Phase 1
21 BB 1101 Phase 1
22 Dexamethasone 21-phosphate Phase 1
23 Dexamethasone acetate Phase 1 1177-87-3
24
Ritonavir Approved, Investigational 155213-67-5 392622
25
Tipranavir Approved, Investigational 174484-41-4 65027
26 Anti-HIV Agents
27 Anti-Infective Agents
28 Anti-Retroviral Agents
29 Antiviral Agents
30 Antibodies
31 Autoantibodies
32 Immunoglobulins

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Twelve Week, Open Label Extension Study in Patients With Schizophrenia Completed NCT01566162 Phase 3
2 PEARL Schizophrenia Maintenance Completed NCT01435928 Phase 3
3 HIV Prevention With the Mentally Ill Completed NCT00643305 Phase 2
4 Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives Recruiting NCT00001529 Phase 1
5 Tipranavir in Patients With Progressive, Systemic HIV-1 Disease Who Have Failed or Are Intolerant to Currently Approved Treatments for HIV Infection Approved for marketing NCT00062660
6 Texting to Improve Adherence in HIV+ With Bipolar Disorder Completed NCT02090634
7 Literacy-Adapted Psychosocial Treatments for Chronic Pain --- "Learning About Mastering/My Pain" Completed NCT01967342
8 An Integrated Program for the Treatment of First Episode of Psychosis Active, not recruiting NCT01321177
9 Neuropsychological Outcomes of Internationally-Adopted Children Who Are Perinatally-Infected With Human Immunodeficiency Virus Enrolling by invitation NCT03100331
10 Serum Auto-Antibodies in Neurological Diseases Enrolling by invitation NCT00704626

Search NIH Clinical Center for Sick Building Syndrome

Cochrane evidence based reviews: sick building syndrome

Genetic Tests for Sick Building Syndrome

Anatomical Context for Sick Building Syndrome

MalaCards organs/tissues related to Sick Building Syndrome:

39
Testes, Eye, Endothelial, Colon

Publications for Sick Building Syndrome

Articles related to Sick Building Syndrome:

(show top 50) (show all 205)
id Title Authors Year
1
Cognitive therapy in sick building syndrome: Myths, believes or evidence. ( 26654822 )
2016
2
Outdoor air pollution, meteorological conditions and indoor factors in dwellings in relation to sick building syndrome (SBS) among adults in China. ( 27101454 )
2016
3
Endotoxin, ergosterol, muramic acid and fungal DNA in dust from schools in Johor Bahru, Malaysia--Associations with rhinitis and sick building syndrome (SBS) in junior high school students. ( 26745297 )
2016
4
Reply to Letter to the Editor: Cognitive therapy in Sick Building Syndrome: Myths, beliefs or evidence. ( 26684264 )
2016
5
Sick building syndrome (SBS) among office workers in a Malaysian university - Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment. ( 26225741 )
2015
6
Association of Sick Building Syndrome with Indoor Air Parameters. ( 26221153 )
2015
7
Assessment of sick building syndrome and its associating factors among nurses in the educational hospitals of Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ( 25716375 )
2015
8
Effect of Traffic Exposure on Sick Building Syndrome Symptoms among Parents/Grandparents of Preschool Children in Beijing, China. ( 26086248 )
2015
9
Sick Building Syndrome Among Junior High School Students in Japan in Relation to the Home and School Environment. ( 26383200 )
2015
10
Social determinants of the sick building syndrome: exploring the interrelated effects of social position and psychosocial situation. ( 25424591 )
2014
11
Effects of ventilation rate per person and per floor area on perceived air quality, sick building syndrome symptoms, and decision-making. ( 25142723 )
2014
12
Allostatic load model associated with indoor environmental quality and sick building syndrome among office workers. ( 24759685 )
2014
13
A Longitudinal Study of Sick Building Syndrome (SBS) among Pupils in Relation to SO2, NO2, O3 and PM10 in Schools in China. ( 25398002 )
2014
14
Odors and sensations of humidity and dryness in relation to sick building syndrome and home environment in Chongqing, China. ( 23991107 )
2013
15
Airborne molds and bacteria, microbial volatile organic compounds (MVOC), plasticizers and formaldehyde in dwellings in three North European cities in relation to sick building syndrome (SBS). ( 23280302 )
2013
16
Association of sick building syndrome with neuropathy target esterase (NTE) activity in Japanese. ( 23418070 )
2013
17
Sick building syndrome by indoor air pollution in Dalian, China. ( 23579877 )
2013
18
Prevalence and risk factors of sick building syndrome among office workers. ( 23963091 )
2013
19
Sick building syndrome (SBS) and sick house syndrome (SHS) in relation to psychosocial stress at work in the Swedish workforce. ( 23143072 )
2013
20
A longitudinal study of aldehydes and volatile organic compounds associated with subjective symptoms related to sick building syndrome in new dwellings in Japan. ( 22265600 )
2012
21
Dampness and moulds in workplace buildings: associations with incidence and remission of sick building syndrome (SBS) and biomarkers of inflammation in a 10 year follow-up study. ( 22634552 )
2012
22
The new model of sick building syndrome. ( 22350575 )
2012
23
Office workers' sick building syndrome and indoor carbon dioxide concentrations. ( 22530709 )
2012
24
The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants. ( 21188456 )
2011
25
A longitudinal study of sick building syndrome among pupils in relation to microbial components in dust in schools in China. ( 21943723 )
2011
26
Sick Building Syndrome and autoimmunity. ( 21300685 )
2011
27
Relationships between mite allergen levels, mold concentrations, and sick building syndrome symptoms in newly built dwellings in Japan. ( 21198888 )
2011
28
The prevalence and incidence of sick building syndrome in Chinese pupils in relation to the school environment: a two-year follow-up study. ( 21615503 )
2011
29
The possible role of fungal contamination in sick building syndrome. ( 21196335 )
2011
30
Sick building syndrome in a general hospital and the risks for pregnant workers. ( 21458809 )
2011
31
Sick building syndrome in relation to domestic exposure in Sweden--a cohort study from 1991 to 2001. ( 19850651 )
2010
32
Dampness, food habits, and sick building syndrome symptoms in elementary school pupils. ( 21432556 )
2010
33
Relationship between indoor chemical concentrations and subjective symptoms associated with sick building syndrome in newly built houses in Japan. ( 19902238 )
2010
34
Association study between sick building syndrome and polymorphisms of seven human detoxification genes in the Japanese. ( 21787601 )
2010
35
Relationship between sick building syndrome and indoor environmental factors in newly built Japanese dwellings. ( 19205722 )
2009
36
An update on sick building syndrome. ( 19532093 )
2009
37
Association of neuroticism with sick building syndrome, quality of life and psychomotor performance. ( 19662780 )
2009
38
Quantitative relationship of sick building syndrome symptoms with ventilation rates. ( 19207289 )
2009
39
A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. ( 19608217 )
2009
40
Sick Building Syndrome: is mould the cause? ( 19255924 )
2009
41
Molds, mycotoxins, and sick building syndrome. ( 19854820 )
2009
42
Relation of dampness to sick building syndrome in Japanese public apartment houses. ( 19568865 )
2009
43
Indoor environment in dwellings, asthma, allergies, and sick building syndrome in the Swedish population: a longitudinal cohort study from 1989 to 1997. ( 19618200 )
2009
44
Do you have sick building syndrome? ( 18648309 )
2008
45
Medical and social prognoses of non-specific building-related symptoms (Sick Building Syndrome): a follow-up study of patients previously referred to hospital. ( 17924130 )
2008
46
Sick building syndrome in relation to air exchange rate, CO(2), room temperature and relative air humidity in university computer classrooms: an experimental study. ( 18246367 )
2008
47
The sick building syndrome. ( 20040980 )
2008
48
Symptom definitions for SBS (sick building syndrome) in residential dwellings. ( 17574916 )
2008
49
Oxidative stress associated with indoor air pollution and sick building syndrome-related symptoms among office workers in Taiwan. ( 17127643 )
2007
50
Office work exposures [corrected] and respiratory and sick building syndrome symptoms. ( 17339295 )
2007

Variations for Sick Building Syndrome

Expression for Sick Building Syndrome

Search GEO for disease gene expression data for Sick Building Syndrome.

Pathways for Sick Building Syndrome

GO Terms for Sick Building Syndrome

Cellular components related to Sick Building Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ITM2B LEP MMP9 POMC VEGFA
2 secretory granule GO:0030141 9.16 POMC VEGFA
3 extracellular region GO:0005576 9.1 ITM2B LEP LRP6 MMP9 POMC VEGFA

Biological processes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.26 LEP POMC
2 dopaminergic neuron differentiation GO:0071542 9.16 LRP6 VEGFA
3 positive regulation of p38MAPK cascade GO:1900745 8.96 LEP VEGFA
4 macrophage differentiation GO:0030225 8.62 MMP9 VEGFA

Molecular functions related to Sick Building Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 8.8 LEP LRP6 POMC

Sources for Sick Building Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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