MCID: SCK001
MIFTS: 42

Sick Building Syndrome malady

Respiratory diseases category

Summaries for Sick Building Syndrome

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Sources:
9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. the disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

MalaCards: Sick Building Syndrome is related to asthma and chronic fatigue syndrome. An important gene associated with Sick Building Syndrome is POMC (proopiomelanocortin), and among its related pathways are Peptide hormone metabolism and Adipocytokine signaling pathway. The compounds shu 9119 and alpha msh have been mentioned in the context of this disorder. Affiliated tissues include eye, colon and endothelial, and related mouse phenotypes are tumorigenesis and immune system.

CDC:4   

Wikipedia:66 Sick building syndrome (SBS) is used to describe situations in which building occupants experience acute... more...

Aliases & Classifications for Sick Building Syndrome

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

sick building syndrome 9 11 63


External Ids:

Disease Ontology9 DOID:2710
SNOMED-CT59 19076009
MeSH36 D018877

Related Diseases for Sick Building Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to sick building syndrome

Symptoms for Sick Building Syndrome

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Drugs & Therapeutics for Sick Building Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Sick Building Syndrome

Drug clinical trials:

Search ClinicalTrials for Sick Building Syndrome

Search NIH Clinical Center for Sick Building Syndrome

Search CenterWatch for Sick Building Syndrome

Genetic Tests for Sick Building Syndrome

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Anatomical Context for Sick Building Syndrome

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Sources:
34MalaCards
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MalaCards organs/tissues related to Sick Building Syndrome:

34
Eye, Colon, Endothelial

Animal Models for Sick Building Syndrome or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Sick Building Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0MMP9, POMC, LEP
2MP:00053878.3MMP9, POMC, LEP, IGHE
3MP:00053978.0IGHE, LEP, POMC, MMP9

Publications for Sick Building Syndrome

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Sources:
53PubMed
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Articles related to Sick Building Syndrome:

(show top 50)    (show all 191)
idTitleAuthorsYear
1
Prevalence and risk factors of sick building syndrome among office workers. (23963091)
2013
2
Sick building syndrome by indoor air pollution in Dalian, China. (23579877)
2013
3
A longitudinal study of aldehydes and volatile organic compounds associated with subjective symptoms related to sick building syndrome in new dwellings in Japan. (22265600)
2012
4
The prevalence and incidence of sick building syndrome in Chinese pupils in relation to the school environment: a two-year follow-up study. (21615503)
2011
5
Sick building syndrome in a general hospital and the risks for pregnant workers. (21458809)
2011
6
The possible role of fungal contamination in sick building syndrome. (21196335)
2011
7
Association study between sick building syndrome and polymorphisms of seven human detoxification genes in the Japanese. (21787601)
2010
8
A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. (19608217)
2009
9
An update on sick building syndrome. (19532093)
2009
10
Case study of volatile organic compounds in indoor air of a house before and after repair where sick building syndrome occurred. (17903361)
2007
11
Projective drawings for assessing stress among subjects with medical symptoms compatible with sick building syndrome, and validation of a modified version of the Stress Load Index from the Drawing Personality Profile: a pilot study. (17450971)
2007
12
Office work exposures [corrected] and respiratory and sick building syndrome symptoms. (17339295)
2007
13
Serum levels of volatile organic compounds in patients with sick building syndrome. (17033858)
2006
14
Associations among sick building syndrome, psychosocial factors, and personality traits. (16060437)
2005
15
Bioaerosols and sick building syndrome: particles, inflammation, and allergy. (15764903)
2005
16
A time-series study of sick building syndrome: chronic, biotoxin-associated illness from exposure to water-damaged buildings. (15681119)
2005
17
Multiple logistic regression modelling substantiates multifactor contributions associated with sick building syndrome in residential interiors in Mauritius. (12745349)
2003
18
The full circle: from the Minamata disaster to the sick building syndrome. (11564629)
2001
19
Why do women suffer from sick building syndrome more often than men?--subjective higher sensitivity versus objective causes. (11761596)
2001
20
Environmental tobacco smoke exposure and overtime work as risk factors for sick building syndrome in Japan. (11682362)
2001
21
The effects of outdoor air supply rate in an office on perceived air quality, sick building syndrome (SBS) symptoms and productivity. (11089327)
2000
22
Sick building syndrome. Indoor air quality and your patients' health. (11521615)
2000
23
The sick building syndrome. (10598396)
1999
24
Sick building syndrome. (10212636)
1999
25
The sick building syndrome as a subjective perception-theoretical approach and assessment methods. (10507132)
1999
26
Visual analogue scales for detecting changes in symptoms of the sick building syndrome in an intervention study. (10505662)
1999
27
Sick building syndrome: association of symptoms with serum IgE specific to fungi. (9561392)
1998
28
Sick-building syndrome. (9235451)
1997
29
Indoor air pollutants and sick building syndrome: a case study and implications for the community health nurse. (9078851)
1997
30
Sick building syndrome, work factors and occupational stress. (8881012)
1996
31
Fungal colonization of fiberglass insulation in the air distribution system of a multi-story office building: VOC production and possible relationship to a sick building syndrome. (8757941)
1996
32
Sick building syndrome and gender bias: imperiling women's health. (7747241)
1995
33
The sick building syndrome and mass hysteria. (7643833)
1995
34
The Sick Building Syndrome (SBS) in office workers. A case-referent study of personal, psychosocial and building-related risk indicators. (7721522)
1994
35
Building and Home-Related Complaints and Illnesses: Sick Building Syndrome. Conference proceedings. Lake Buena Vista, Florida, December 3-5, 1992. (7915735)
1994
36
Textile wall materials and sick building syndrome. (8185388)
1994
37
Town planning & health. Sick building syndrome. (10135739)
1994
38
Building components contributors of the sick building syndrome. (8175632)
1994
39
The effect of varying levels of outdoor-air supply on the symptoms of sick building syndrome. (8441426)
1993
40
Building-related illnesses and sick building syndrome. (8089648)
1993
41
Sick building syndrome--know your ventilation rates. (10126689)
1993
42
The feasibility of using a double blind experimental cross-over design to study interventions for sick building syndrome. (1607899)
1992
43
The sick building syndrome. (1580467)
1992
44
Field studies on the sick building syndrome. (1580471)
1992
45
High prevalence of sick building syndrome in a new air-conditioned building in Italy. (1539998)
1992
46
Sick building syndrome. (1683923)
1991
47
Environmental, occupational, and personal factors related to the prevalence of sick building syndrome in the general population. (1854648)
1991
48
The sick building syndrome: where is the epidemiologic basis? (2400024)
1990
49
Sick building syndrome. (2616483)
1989
50
The sick building syndrome. (3917804)
1985

Variations for Sick Building Syndrome

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Expression for genes affiliated with Sick Building Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Building Syndrome

Search GEO for disease gene expression data for Sick Building Syndrome.

Pathways for genes affiliated with Sick Building Syndrome

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters
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Pathways related to Sick Building Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6POMC, LEP
29.6POMC, LEP
3
Show member pathways
9.6POMC, LEP
49.5MMP9, LEP

Compounds for genes affiliated with Sick Building Syndrome

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Sources:
62Tocris Bioscience, 46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank, 30IUPHAR
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Compounds related to Sick Building Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1shu 911962 4611.0POMC, LEP
2alpha msh4610.0POMC, LEP
3megestrol acetate4610.0LEP, POMC
4topiramate46 52 25 1213.0LEP, POMC
5thiopental46 1211.0POMC, LEP
6fenfluramine46 30 1212.0LEP, POMC
7cortisone46 2510.9POMC, LEP
811beta-hydroxysteroid469.9LEP, POMC
9naloxone46 30 52 1212.9LEP, POMC
10dehydroepiandrosterone sulfate469.9POMC, LEP
11clonidine46 52 30 1212.9LEP, POMC
128-isoprostane469.8LEP, MMP9
13fenofibrate46 52 1211.7LEP, MMP9
14beclomethasone dipropionate469.7POMC, IGHE
15ribavirin46 52 1211.6MMP9, LEP
16dhea469.6LEP, POMC
17heroin46 52 1211.6IGHE, POMC
18propofol46 52 1211.5IGHE, POMC
19metformin46 52 1211.5POMC, LEP
20gnrh469.5POMC, LEP, RGS3
21gaba469.5LEP, POMC, MMP9
22paraffin469.4LEP, MMP9, POMC
23ganciclovir46 1210.3POMC, LEP
24ivig469.3IGHE, MMP9
25budesonide46 52 1211.2IGHE, LEP, POMC
26thyroxine46 2510.2POMC, LEP, IGHE
27capsaicin46 3010.2LEP, IGHE
28glycerol46 25 1211.2IGHE, POMC, LEP
29fluticasone propionate46 52 62 1212.2MMP9, IGHE, POMC
30ascorbic acid46 2510.1IGHE, POMC, LEP
31indomethacin46 30 62 1212.1POMC, IGHE, LEP
32l-nmma469.1LEP, IGHE, MMP9
33acetylcholine46 52 30 25 1213.1POMC, LEP, IGHE
34inositol469.1LEP, IGHE, MMP9
35nicotine46 30 52 1212.1LEP, MMP9, IGHE
36vitamin a46 25 1211.1LEP, IGHE, MMP9
37methotrexate52 46 1211.1IGHE, MMP9, LEP
38n acetylcysteine469.0IGHE, MMP9, LEP
39heparin46 30 25 1212.0LEP, IGHE, POMC
40aspartate468.9POMC, MMP9, IGHE
41adenylate468.8IGHE, POMC, MMP9
42epinephrine46 25 1210.7IGHE, LEP, POMC, MMP9
43norepinephrine46 25 1210.7MMP9, LEP, POMC, IGHE
44cyclosporin a46 30 6210.7IGHE, POMC, MMP9, LEP
45creatinine468.7MMP9, POMC, LEP, IGHE
46cycloheximide468.7MMP9, LEP, POMC, IGHE
47testosterone46 62 25 1211.7IGHE, LEP, POMC, MMP9
48dexamethasone46 52 30 1211.7LEP, POMC, IGHE, MMP9
49vegf468.7IGHE, MMP9, POMC, LEP
50estrogen468.6LEP, POMC, MMP9, IGHE

GO Terms for genes affiliated with Sick Building Syndrome

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Sources:
17Gene Ontology
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Cellular components related to Sick Building Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1MMP9, POMC, LEP
2extracellular regionGO:0055768.0MMP9, POMC, LEP, IGHE

Biological processes related to Sick Building Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.6POMC, LEP

Molecular functions related to Sick Building Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6POMC, LEP

Products for genes affiliated with Sick Building Syndrome

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  • Antibodies
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  • Antibodies

Sources for Sick Building Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet