MCID: SCK001
MIFTS: 36

Sick Building Syndrome

Categories: Respiratory diseases

Aliases & Classifications for Sick Building Syndrome

MalaCards integrated aliases for Sick Building Syndrome:

Name: Sick Building Syndrome 12 3 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2710
MeSH 41 D018877
SNOMED-CT 64 19076009
UMLS 69 C0037050

Summaries for Sick Building Syndrome

CDC : 3 Indoor environmental quality (IEQ) refers to the quality of a building’s environment in relation to the health and wellbeing of those who occupy space within it. IEQ is determined by many factors, including lighting, air quality, and damp conditions. Workers are often concerned that they have symptoms or health conditions from exposures to contaminants in the buildings where they work. One reason for this concern is that their symptoms often get better when they are not in the building. While research has shown that some respiratory symptoms and illnesses can be associated with damp buildings, it is still unclear what measurements of indoor contaminants show that workers are at risk for disease. In most instances where a worker and his or her physician suspect that the building environment is causing a specific health condition, the information available from medical tests and tests of the environment is not sufficient to establish which contaminants are responsible. Despite uncertainty about what to measure and how to interpret what is measured, research shows that building-related symptoms are associated with building characteristics, including dampness, cleanliness, and ventilation characteristics.

MalaCards based summary : Sick Building Syndrome is related to asthma and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. An important gene associated with Sick Building Syndrome is PNPLA6 (Patatin Like Phospholipase Domain Containing 6), and among its related pathways/superpathways are Bladder cancer and Adipocytokine signaling pathway. Affiliated tissues include testes, eye and endothelial, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

Wikipedia : 72 Sick building syndrome (SBS) is a medical condition where people in a building suffer from symptoms of... more...

Related Diseases for Sick Building Syndrome

Diseases related to Sick Building Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 asthma 28.6 LEP MMP9 POMC TRPV1
2 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.2 LEP POMC
3 endocrine pancreas disease 10.2 LEP POMC
4 adrenal gland hyperfunction 10.2 LEP POMC
5 amenorrhea 10.1 LEP POMC
6 eating disorder 10.1 LEP POMC
7 opiate dependence 10.1 POMC VEGFA
8 pituitary tumors 10.1 POMC VEGFA
9 angiokeratoma circumscriptum 10.1 MMP9 VEGFA
10 squamous cell carcinoma of the hypopharynx 10.1 MMP9 VEGFA
11 adamantinous craniopharyngioma 10.1 MMP9 VEGFA
12 microcystic meningioma 10.1 MMP9 VEGFA
13 adenomyosis 10.1 MMP9 VEGFA
14 odontogenic myxoma 10.1 MMP9 VEGFA
15 bulimia nervosa 2 10.1 LEP POMC
16 tuberculous meningitis 10.1 MMP9 VEGFA
17 arteriovenous malformation 10.1 MMP9 VEGFA
18 keratitis, hereditary 10.0 MMP9 VEGFA
19 microvascular complications of diabetes 1 10.0 MMP9 VEGFA
20 varicose veins 10.0 MMP9 VEGFA
21 brain edema 10.0 MMP9 VEGFA
22 placental insufficiency 10.0 LEP VEGFA
23 ovarian cancer 1 10.0 MMP9 VEGFA
24 ige responsiveness, atopic 10.0
25 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
26 multiple chemical sensitivity 10.0
27 chronic fatigue syndrome 10.0
28 female reproductive organ cancer 10.0 MMP9 VEGFA
29 pain agnosia 10.0 POMC TRPV1
30 agnosia 10.0 POMC TRPV1
31 toxic encephalopathy 9.9 PNPLA6 TRPV1
32 peripheral nervous system disease 9.9 PNPLA6 TRPV1
33 reproductive organ cancer 9.9 MMP9 VEGFA
34 aging 9.8
35 anxiety 9.8
36 legionnaire disease 9.8
37 sinusitis 9.8
38 legionnaires' disease 9.8
39 plague 9.8
40 rhinitis 9.8
41 neuropathy 9.8
42 stachybotrys chartarum 9.8
43 streptococcal group a invasive disease 9.8
44 endotheliitis 9.8
45 bone cancer 9.8 MMP9 TRPV1
46 specific developmental disorder 9.8 POMC TRPV1
47 respiratory system disease 9.8 MMP9 TRPV1
48 gastrointestinal system cancer 9.8 MMP9 VEGFA
49 connective tissue cancer 9.8 TRPV1 VEGFA
50 urinary system disease 9.8 POMC TRPV1

Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to Sick Building Syndrome

Symptoms & Phenotypes for Sick Building Syndrome

MGI Mouse Phenotypes related to Sick Building Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 ITM2B LEP TRPV1 MMP9 VEGFA PNPLA6
2 cardiovascular system MP:0005385 9.91 POMC LEP TRPV1 MMP9 VEGFA PNPLA6
3 cellular MP:0005384 9.88 POMC LEP TRPV1 MMP9 VEGFA PNPLA6
4 growth/size/body region MP:0005378 9.85 POMC LEP TRPV1 MMP9 VEGFA PNPLA6
5 integument MP:0010771 9.8 POMC LEP TRPV1 MMP9 VEGFA PNPLA6
6 liver/biliary system MP:0005370 9.56 POMC LEP TRPV1 VEGFA
7 neoplasm MP:0002006 9.55 POMC LEP TRPV1 MMP9 VEGFA
8 nervous system MP:0003631 9.5 POMC ITM2B LEP TRPV1 MMP9 VEGFA
9 renal/urinary system MP:0005367 9.02 POMC LEP TRPV1 MMP9 VEGFA

Drugs & Therapeutics for Sick Building Syndrome

Search Clinical Trials , NIH Clinical Center for Sick Building Syndrome

Cochrane evidence based reviews: sick building syndrome

Genetic Tests for Sick Building Syndrome

Anatomical Context for Sick Building Syndrome

MalaCards organs/tissues related to Sick Building Syndrome:

38
Testes, Eye, Endothelial, Colon

Publications for Sick Building Syndrome

Articles related to Sick Building Syndrome:

(show top 50) (show all 207)
# Title Authors Year
1
Clinical and allergological analysis of ocular manifestations of sick building syndrome. ( 28352150 )
2017
2
Personal, Psychosocial and Environmental Factors Related to Sick Building Syndrome in Official Employees of Taiwan. ( 29271881 )
2017
3
Reply to Letter to the Editor: Cognitive therapy in Sick Building Syndrome: Myths, beliefs or evidence. ( 26684264 )
2016
4
Cognitive therapy in sick building syndrome: Myths, believes or evidence. ( 26654822 )
2016
5
Outdoor air pollution, meteorological conditions and indoor factors in dwellings in relation to sick building syndrome (SBS) among adults in China. ( 27101454 )
2016
6
Endotoxin, ergosterol, muramic acid and fungal DNA in dust from schools in Johor Bahru, Malaysia--Associations with rhinitis and sick building syndrome (SBS) in junior high school students. ( 26745297 )
2016
7
Effect of Traffic Exposure on Sick Building Syndrome Symptoms among Parents/Grandparents of Preschool Children in Beijing, China. ( 26086248 )
2015
8
Assessment of sick building syndrome and its associating factors among nurses in the educational hospitals of Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ( 25716375 )
2015
9
Association of Sick Building Syndrome with Indoor Air Parameters. ( 26221153 )
2015
10
Sick building syndrome (SBS) among office workers in a Malaysian university - Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment. ( 26225741 )
2015
11
Sick Building Syndrome Among Junior High School Students in Japan in Relation to the Home and School Environment. ( 26383200 )
2015
12
Social determinants of the sick building syndrome: exploring the interrelated effects of social position and psychosocial situation. ( 25424591 )
2014
13
Effects of ventilation rate per person and per floor area on perceived air quality, sick building syndrome symptoms, and decision-making. ( 25142723 )
2014
14
Allostatic load model associated with indoor environmental quality and sick building syndrome among office workers. ( 24759685 )
2014
15
A Longitudinal Study of Sick Building Syndrome (SBS) among Pupils in Relation to SO2, NO2, O3 and PM10 in Schools in China. ( 25398002 )
2014
16
Prevalence and risk factors of sick building syndrome among office workers. ( 23963091 )
2013
17
Association of sick building syndrome with neuropathy target esterase (NTE) activity in Japanese. ( 23418070 )
2013
18
Sick building syndrome (SBS) and sick house syndrome (SHS) in relation to psychosocial stress at work in the Swedish workforce. ( 23143072 )
2013
19
Airborne molds and bacteria, microbial volatile organic compounds (MVOC), plasticizers and formaldehyde in dwellings in three North European cities in relation to sick building syndrome (SBS). ( 23280302 )
2013
20
Odors and sensations of humidity and dryness in relation to sick building syndrome and home environment in Chongqing, China. ( 23991107 )
2013
21
Sick building syndrome by indoor air pollution in Dalian, China. ( 23579877 )
2013
22
The new model of sick building syndrome. ( 22350575 )
2012
23
Office workers' sick building syndrome and indoor carbon dioxide concentrations. ( 22530709 )
2012
24
Dampness and moulds in workplace buildings: associations with incidence and remission of sick building syndrome (SBS) and biomarkers of inflammation in a 10 year follow-up study. ( 22634552 )
2012
25
A longitudinal study of aldehydes and volatile organic compounds associated with subjective symptoms related to sick building syndrome in new dwellings in Japan. ( 22265600 )
2012
26
The possible role of fungal contamination in sick building syndrome. ( 21196335 )
2011
27
The prevalence and incidence of sick building syndrome in Chinese pupils in relation to the school environment: a two-year follow-up study. ( 21615503 )
2011
28
Sick Building Syndrome and autoimmunity. ( 21300685 )
2011
29
Relationships between mite allergen levels, mold concentrations, and sick building syndrome symptoms in newly built dwellings in Japan. ( 21198888 )
2011
30
Sick building syndrome in a general hospital and the risks for pregnant workers. ( 21458809 )
2011
31
The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants. ( 21188456 )
2011
32
A longitudinal study of sick building syndrome among pupils in relation to microbial components in dust in schools in China. ( 21943723 )
2011
33
Dampness, food habits, and sick building syndrome symptoms in elementary school pupils. ( 21432556 )
2010
34
Sick building syndrome in relation to domestic exposure in Sweden--a cohort study from 1991 to 2001. ( 19850651 )
2010
35
Relationship between indoor chemical concentrations and subjective symptoms associated with sick building syndrome in newly built houses in Japan. ( 19902238 )
2010
36
Association study between sick building syndrome and polymorphisms of seven human detoxification genes in the Japanese. ( 21787601 )
2010
37
Association of neuroticism with sick building syndrome, quality of life and psychomotor performance. ( 19662780 )
2009
38
Indoor environment in dwellings, asthma, allergies, and sick building syndrome in the Swedish population: a longitudinal cohort study from 1989 to 1997. ( 19618200 )
2009
39
Relation of dampness to sick building syndrome in Japanese public apartment houses. ( 19568865 )
2009
40
A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. ( 19608217 )
2009
41
An update on sick building syndrome. ( 19532093 )
2009
42
Sick Building Syndrome: is mould the cause? ( 19255924 )
2009
43
Relationship between sick building syndrome and indoor environmental factors in newly built Japanese dwellings. ( 19205722 )
2009
44
Quantitative relationship of sick building syndrome symptoms with ventilation rates. ( 19207289 )
2009
45
Molds, mycotoxins, and sick building syndrome. ( 19854820 )
2009
46
Sick building syndrome in relation to air exchange rate, CO(2), room temperature and relative air humidity in university computer classrooms: an experimental study. ( 18246367 )
2008
47
Symptom definitions for SBS (sick building syndrome) in residential dwellings. ( 17574916 )
2008
48
The sick building syndrome. ( 20040980 )
2008
49
Do you have sick building syndrome? ( 18648309 )
2008
50
Medical and social prognoses of non-specific building-related symptoms (Sick Building Syndrome): a follow-up study of patients previously referred to hospital. ( 17924130 )
2008

Variations for Sick Building Syndrome

Expression for Sick Building Syndrome

Search GEO for disease gene expression data for Sick Building Syndrome.

Pathways for Sick Building Syndrome

GO Terms for Sick Building Syndrome

Cellular components related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 ITM2B LEP MMP9 POMC VEGFA
2 secretory granule GO:0030141 9.16 POMC VEGFA
3 extracellular space GO:0005615 9.02 ITM2B LEP MMP9 POMC VEGFA

Biological processes related to Sick Building Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.5 LEP POMC VEGFA
2 regulation of blood pressure GO:0008217 9.26 LEP POMC
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.16 LEP VEGFA
4 positive regulation of p38MAPK cascade GO:1900745 8.96 LEP VEGFA
5 macrophage differentiation GO:0030225 8.62 MMP9 VEGFA

Sources for Sick Building Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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