MCID: SCK001
MIFTS: 38

Sick Building Syndrome malady

Summaries for Sick Building Syndrome

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Indoor environmental quality (IEQ) refers to the quality of a building’s environment in relation to the health and wellbeing of those who occupy space within it.   IEQ is determined by many factors, including lighting, air quality, and damp conditions. Workers are often concerned that they have symptoms or health conditions from exposures to contaminants in the buildings where they work.  One reason for this concern is that their symptoms often get better when they are not in the building. While research has shown that some respiratory symptoms and illnesses can be associated with damp buildings, it is still unclear what measurements of indoor contaminants show that workers are at risk for disease.  In most instances where a worker and his or her physician suspect that the building environment is causing a specific health condition, the information available from medical tests and tests of the environment is not sufficient to establish which contaminants are responsible.  Despite uncertainty about what to measure and how to interpret what is measured, research shows that building-related symptoms are associated with building characteristics, including dampness, cleanliness, and ventilation characteristics.

MalaCards: Sick Building Syndrome is related to neuropathy and asthma. An important gene associated with Sick Building Syndrome is ITM2B (integral membrane protein 2B), and among its related pathways is Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds shu 9119 and alpha msh have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and endothelial, and related mouse phenotype tumorigenesis.

Disease Ontology:8 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. the disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

Wikipedia:63 Sick building syndrome (SBS) is used to describe situations in which building occupants experience acute... more...

Aliases & Classifications for Sick Building Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

sick building syndrome 8 10 60


External Ids:

Disease Ontology8 DOID:2710
SNOMED-CT56 19076009
MeSH34 D018877

Related Diseases for Sick Building Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to sick building syndrome

Clinical Features for Sick Building Syndrome

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Drugs & Therapeutics for Sick Building Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sick Building Syndrome

Drug clinical trials:

Search ClinicalTrials for Sick Building Syndrome

Search NIH Clinical Center for Sick Building Syndrome

Search CenterWatch for Sick Building Syndrome

Genetic Tests for Sick Building Syndrome

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Anatomical Context for Sick Building Syndrome

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32MalaCards
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MalaCards organs/tissues related to Sick Building Syndrome:

32
Testes, Eye, Endothelial, Colon

Animal Models for Sick Building Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sick Building Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0LEP, MMP9, POMC, TRPV1

Publications for Sick Building Syndrome

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50PubMed
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Articles related to Sick Building Syndrome:

(show top 50)    (show all 192)
idTitleAuthorsYear
1
Airborne molds and bacteria, microbial volatile organic compounds (MVOC), plasticizers and formaldehyde in dwellings in three North European cities in relation to sick building syndrome (SBS). (23280302)
2013
2
A longitudinal study of aldehydes and volatile organic compounds associated with subjective symptoms related to sick building syndrome in new dwellings in Japan. (22265600)
2012
3
Office workers' sick building syndrome and indoor carbon dioxide concentrations. (22530709)
2012
4
The new model of sick building syndrome. (22350575)
2012
5
The possible role of fungal contamination in sick building syndrome. (21196335)
2011
6
Dampness, food habits, and sick building syndrome symptoms in elementary school pupils. (21432556)
2010
7
Relationship between indoor chemical concentrations and subjective symptoms associated with sick building syndrome in newly built houses in Japan. (19902238)
2010
8
Relationship between sick building syndrome and indoor environmental factors in newly built Japanese dwellings. (19205722)
2009
9
Relation of dampness to sick building syndrome in Japanese public apartment houses. (19568865)
2009
10
Association of neuroticism with sick building syndrome, quality of life and psychomotor performance. (19662780)
2009
11
The sick building syndrome. (20040980)
2008
12
Medical and social prognoses of non-specific building-related symptoms (Sick Building Syndrome): a follow-up study of patients previously referred to hospital. (17924130)
2008
13
Do you have sick building syndrome? (18648309)
2008
14
Case study of volatile organic compounds in indoor air of a house before and after repair where sick building syndrome occurred. (17903361)
2007
15
Sick building syndrome: psychological, somatic, and environmental determinants. (18400655)
2007
16
Personal and psychosocial factors and symptoms compatible with sick building syndrome in the Swedish workforce. (17100665)
2006
17
Fungal contamination as a major contributor to sick building syndrome. (15350790)
2004
18
Sick building syndrome in like symptoms in emergency prefabricated accommodation. (15345200)
2004
19
Possible role of fungal hemolysins in sick building syndrome. (15350795)
2004
20
Studies on the role of fungi in Sick Building Syndrome. (15259426)
2003
21
The full circle: from the Minamata disaster to the sick building syndrome. (11564629)
2001
22
The ultimate sick building syndrome. (11703163)
2001
23
The effects of outdoor air supply rate in an office on perceived air quality, sick building syndrome (SBS) symptoms and productivity. (11089327)
2000
24
Resolution of sick building syndrome in a high-security facility. (10957819)
2000
25
Associations between indoor CO2 concentrations and sick building syndrome symptoms in U.S. office buildings: an analysis of the 1994-1996 BASE study data. (11089329)
2000
26
The sick building syndrome. (10598396)
1999
27
The sick-building-syndrome--do women suffer more? (10507131)
1999
28
Symptoms related to the sick building syndrome in a general population sample: associations with atopy, bronchial hyper-responsiveness and anxiety. (9869120)
1998
29
Sick building syndrome--a wolf in sheep's clothing. (9357372)
1997
30
Sick building syndrome: an emerging stress-related disorder? (9447404)
1997
31
Sick building syndrome, work factors and occupational stress. (8881012)
1996
32
New and emerging pathogens, Part 6. Sick-building syndrome and building-related illness. (10162473)
1996
33
Beyond air quality--factors that affect prevalence estimates of sick building syndrome. (7502997)
1995
34
Influence of indoor air quality and personal factors on the sick building syndrome (SBS) in Swedish geriatric hospitals. (7735389)
1995
35
Town planning & health. Sick building syndrome. (10135739)
1994
36
Building components contributors of the sick building syndrome. (8175632)
1994
37
A toxicologic approach for evaluating cases of sick building syndrome or multiple chemical sensitivity. (8077592)
1994
38
Air recirculation and sick building syndrome: a blinded crossover trial. (8129059)
1994
39
Sick building syndrome--a case study in Zagreb. (8067907)
1994
40
Sick building syndrome--know your ventilation rates. (10126689)
1993
41
Sick building syndrome. (8332161)
1993
42
The sick building syndrome. II. Assessment and regulation of indoor air quality. (8331041)
1993
43
Sick building syndrome. (8332159)
1993
44
The feasibility of using a double blind experimental cross-over design to study interventions for sick building syndrome. (1607899)
1992
45
The sick building syndrome. (1580467)
1992
46
Sick building syndrome. (1683923)
1991
47
Sick building syndrome. (2616483)
1989
48
Clinical diagnosis and management of building-related illness and the sick-building syndrome. (2690376)
1989
49
Legionnaires' disease and the sick-building syndrome. (2680548)
1989
50
Sick building syndrome: a study of 4373 office workers. (3439759)
1987

Genetic Variations for Sick Building Syndrome

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Expression for genes affiliated with Sick Building Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Building Syndrome

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Pathways for genes affiliated with Sick Building Syndrome

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12EMD Millipore
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Pathways related to Sick Building Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.7LEP, POMC

Compounds for genes affiliated with Sick Building Syndrome

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Sick Building Syndrome according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1shu 911944 5911.1LEP, POMC
2alpha msh4410.1LEP, POMC
3megestrol acetate4410.1LEP, POMC
4topiramate44 11 2412.1LEP, POMC
5thiopental44 1111.1LEP, POMC
6fenfluramine28 44 1112.1POMC, LEP
7cortisone44 2411.1LEP, POMC
88-isoprostane449.8LEP, MMP9
9formaldehyde44 2410.8TRPV1, POMC, MMP9
10anandamide44 28 59 2412.7LEP, TRPV1
11beclomethasone dipropionate449.7IGHE, POMC
1211beta-hydroxysteroid449.6POMC, LEP
13heroin44 49 1111.6POMC, IGHE
14gnrh449.5RGS3, LEP, POMC
15gaba449.4TRPV1, POMC, MMP9, LEP
16lidocaine44 28 1111.4TRPV1, IGHE
17fluticasone propionate44 49 59 1112.4MMP9, POMC, IGHE
18budesonide44 49 1111.3IGHE, POMC, LEP
19propofol44 49 1111.3POMC, IGHE
20capsaicin44 2810.3LEP, TRPV1, IGHE
21thyroxine44 2410.3LEP, POMC, IGHE
22l-nmma449.3LEP, MMP9, IGHE
23glycerol44 11 2411.2LEP, POMC, IGHE
24vitamin a44 11 2411.2LEP, MMP9, IGHE
25methotrexate44 49 1111.1IGHE, MMP9, LEP
26ascorbic acid44 2410.1LEP, POMC, IGHE
27n acetylcysteine449.1IGHE, MMP9, LEP
28indomethacin44 59 28 1112.1IGHE, POMC, LEP
29adenylate449.0IGHE, TRPV1, POMC, MMP9
30epinephrine44 11 2411.0IGHE, POMC, MMP9, LEP
31inositol448.9IGHE, TRPV1, MMP9, LEP
32nicotine44 49 28 1111.9LEP, MMP9, TRPV1, IGHE
33norepinephrine44 11 2410.9IGHE, POMC, MMP9, LEP
34creatinine448.9IGHE, POMC, MMP9, LEP
35cycloheximide448.9LEP, MMP9, POMC, IGHE
36testosterone44 59 11 2411.9IGHE, POMC, MMP9, LEP
37dexamethasone44 49 28 1111.8IGHE, POMC, MMP9, LEP
38vegf448.8LEP, MMP9, POMC, IGHE
39cyclosporin a44 28 5910.6LEP, MMP9, POMC, TRPV1, IGHE
40glutamate448.2LEP, MMP9, TRPV1, IGHE

GO Terms for genes affiliated with Sick Building Syndrome

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16Gene Ontology
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Cellular components related to Sick Building Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1LEP, MMP9, POMC, ITM2B
2extracellular regionGO:0055767.9LEP, MMP9, POMC, IGHE, ITM2B

Products for genes affiliated with Sick Building Syndrome

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Sources for Sick Building Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet