MCID: SCK001
MIFTS: 38

Sick Building Syndrome malady

Summaries for Sick Building Syndrome

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Indoor environmental quality (IEQ) refers to the quality of a building’s environment in relation to the health and wellbeing of those who occupy space within it.   IEQ is determined by many factors, including lighting, air quality, and damp conditions. Workers are often concerned that they have symptoms or health conditions from exposures to contaminants in the buildings where they work.  One reason for this concern is that their symptoms often get better when they are not in the building. While research has shown that some respiratory symptoms and illnesses can be associated with damp buildings, it is still unclear what measurements of indoor contaminants show that workers are at risk for disease.  In most instances where a worker and his or her physician suspect that the building environment is causing a specific health condition, the information available from medical tests and tests of the environment is not sufficient to establish which contaminants are responsible.  Despite uncertainty about what to measure and how to interpret what is measured, research shows that building-related symptoms are associated with building characteristics, including dampness, cleanliness, and ventilation characteristics.

MalaCards: Sick Building Syndrome is related to neuropathy and asthma. An important gene associated with Sick Building Syndrome is ITM2B (integral membrane protein 2B), and among its related pathways is Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds shu 9119 and alpha msh have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and colon, and related mouse phenotype tumorigenesis.

Disease Ontology:8 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. the disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

Wikipedia:63 Sick building syndrome (SBS) is used to describe situations in which building occupants experience acute... more...

Aliases & Classifications for Sick Building Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

sick building syndrome 8 10 60


External Ids:

Disease Ontology8 DOID:2710
SNOMED-CT56 19076009
MeSH34 D018877

Related Diseases for Sick Building Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to sick building syndrome

Clinical Features for Sick Building Syndrome

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Drugs & Therapeutics for Sick Building Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sick Building Syndrome

Drug clinical trials:

Search ClinicalTrials for Sick Building Syndrome

Search NIH Clinical Center for Sick Building Syndrome

Search CenterWatch for Sick Building Syndrome

Genetic Tests for Sick Building Syndrome

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Anatomical Context for Sick Building Syndrome

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32MalaCards
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MalaCards organs/tissues related to Sick Building Syndrome:

32
Testes, Eye, Colon, Endothelial

Animal Models for Sick Building Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Sick Building Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0LEP, MMP9, POMC, TRPV1

Publications for Sick Building Syndrome

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50PubMed
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Articles related to Sick Building Syndrome:

(show top 50)    (show all 192)
idTitleAuthorsYear
1
The prevalence and incidence of sick building syndrome in Chinese pupils in relation to the school environment: a two-year follow-up study. (21615503)
2011
2
Sick Building Syndrome and autoimmunity. (21300685)
2011
3
A longitudinal study of sick building syndrome among pupils in relation to microbial components in dust in schools in China. (21943723)
2011
4
The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants. (21188456)
2011
5
A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. (19608217)
2009
6
Molds, mycotoxins, and sick building syndrome. (19854820)
2009
7
Sick building syndrome in relation to air exchange rate, CO(2), room temperature and relative air humidity in university computer classrooms: an experimental study. (18246367)
2008
8
Serum levels of volatile organic compounds in patients with sick building syndrome. (17033858)
2006
9
The sick building syndrome: a chicken and egg situation? (16408193)
2006
10
No consistent risk factor pattern for symptoms related to the sick building syndrome: a prospective population based study. (16404637)
2006
11
A time-series study of sick building syndrome: chronic, biotoxin-associated illness from exposure to water-damaged buildings. (15681119)
2005
12
Effect of chlorine dioxide gas on fungi and mycotoxins associated with sick building syndrome. (16151130)
2005
13
The roles of Penicillium and Aspergillus in sick building syndrome. (15350796)
2004
14
Culturability and toxicity of sick building syndrome-related fungi over time. (15238302)
2004
15
Sick building syndrome. (14739390)
2004
16
Environmental tobacco smoke exposure and overtime work as risk factors for sick building syndrome in Japan. (11682362)
2001
17
Sick building syndrome in relation to building dampness in multi-family residential buildings in Stockholm. (11401019)
2001
18
Sick building syndrome. (10212636)
1999
19
The sick building syndrome as a subjective perception-theoretical approach and assessment methods. (10507132)
1999
20
A comparison of two studies reporting the prevalence of the sick building syndrome in New Zealand and England. (10448996)
1999
21
Sick building syndrome in an office building formerly used by a pharmaceutical company: a case study. (10390939)
1999
22
Perceived air quality, sick building syndrome (SBS) symptoms and productivity in an office with two different pollution loads. (10439554)
1999
23
Sick building syndrome: association of symptoms with serum IgE specific to fungi. (9561392)
1998
24
The sick building syndrome: a diagnostic dilemma. (9783873)
1998
25
Indoor air pollutants and sick building syndrome: a case study and implications for the community health nurse. (9078851)
1997
26
The natural history of concurrent sick building syndrome and chronic fatigue syndrome. (9201647)
1997
27
Sick-building syndrome. (9217781)
1997
28
Prevalence of the sick building syndrome symptoms in office workers before and six months and three years after being exposed to a building with an improved ventilation system. (9072034)
1997
29
Sick-building syndrome in a tropical city. (8622382)
1996
30
Sick building syndrome. (8637130)
1996
31
Molds, fungi cause sick building syndrome. (8570119)
1996
32
Sick building syndrome and gender bias: imperiling women's health. (7747241)
1995
33
The sick building syndrome and mass hysteria. (7643833)
1995
34
Type of ventilation system in office buildings and sick building syndrome. (7709918)
1995
35
Do microbes contribute to sick building syndrome? (22667235)
1995
36
The Sick Building Syndrome (SBS) in office workers. A case-referent study of personal, psychosocial and building-related risk indicators. (7721522)
1994
37
Textile wall materials and sick building syndrome. (8185388)
1994
38
An investigation into sick building syndrome among local authority employees. (7978993)
1994
39
Effect of air humidification on the sick building syndrome and perceived indoor air quality in hospitals: a four month longitudinal study. (8000493)
1994
40
The effect of varying levels of outdoor-air supply on the symptoms of sick building syndrome. (8441426)
1993
41
The sick building syndrome. I. Definition and epidemiological considerations. (8331040)
1993
42
Sick building syndrome in a Canadian office complex. (8215593)
1993
43
Serum myeloperoxidase and sick building syndrome. (8100878)
1993
44
Field studies on the sick building syndrome. (1580471)
1992
45
Sick building syndrome. Medical evaluation of two work forces. (1464788)
1992
46
Controlled experiments for studies of the sick building syndrome. (1580480)
1992
47
Sick building syndrome and sinusitis. (1346208)
1992
48
Sick building syndrome. (1986430)
1991
49
Experts in disarray over sick building syndrome--is it 'all in the mind'? (2740046)
1989
50
The sick building syndrome. (3917804)
1985

Genetic Variations for Sick Building Syndrome

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Expression for genes affiliated with Sick Building Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Building Syndrome

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Pathways for genes affiliated with Sick Building Syndrome

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12EMD Millipore
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Pathways related to Sick Building Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Leptin signaling via JAK/STAT and MAPK cascades
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9.7LEP, POMC

Compounds for genes affiliated with Sick Building Syndrome

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB
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Compounds related to Sick Building Syndrome according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1shu 911944 5911.1LEP, POMC
2alpha msh4410.1LEP, POMC
3megestrol acetate4410.1LEP, POMC
4topiramate44 11 2412.1LEP, POMC
5thiopental44 1111.1LEP, POMC
6fenfluramine28 44 1112.1POMC, LEP
7cortisone44 2411.1LEP, POMC
88-isoprostane449.8LEP, MMP9
9formaldehyde44 2410.8TRPV1, POMC, MMP9
10anandamide44 28 59 2412.7LEP, TRPV1
11beclomethasone dipropionate449.7IGHE, POMC
1211beta-hydroxysteroid449.6POMC, LEP
13heroin44 49 1111.6POMC, IGHE
14gnrh449.5RGS3, LEP, POMC
15gaba449.4TRPV1, POMC, MMP9, LEP
16lidocaine44 28 1111.4TRPV1, IGHE
17fluticasone propionate44 49 59 1112.4MMP9, POMC, IGHE
18budesonide44 49 1111.3IGHE, POMC, LEP
19propofol44 49 1111.3POMC, IGHE
20capsaicin44 2810.3LEP, TRPV1, IGHE
21thyroxine44 2410.3LEP, POMC, IGHE
22l-nmma449.3LEP, MMP9, IGHE
23glycerol44 11 2411.2LEP, POMC, IGHE
24vitamin a44 11 2411.2LEP, MMP9, IGHE
25methotrexate44 49 1111.1IGHE, MMP9, LEP
26ascorbic acid44 2410.1LEP, POMC, IGHE
27n acetylcysteine449.1IGHE, MMP9, LEP
28indomethacin44 59 28 1112.1IGHE, POMC, LEP
29adenylate449.0IGHE, TRPV1, POMC, MMP9
30epinephrine44 11 2411.0IGHE, POMC, MMP9, LEP
31inositol448.9IGHE, TRPV1, MMP9, LEP
32nicotine44 49 28 1111.9LEP, MMP9, TRPV1, IGHE
33norepinephrine44 11 2410.9IGHE, POMC, MMP9, LEP
34creatinine448.9IGHE, POMC, MMP9, LEP
35cycloheximide448.9LEP, MMP9, POMC, IGHE
36testosterone44 59 11 2411.9IGHE, POMC, MMP9, LEP
37dexamethasone44 49 28 1111.8IGHE, POMC, MMP9, LEP
38vegf448.8LEP, MMP9, POMC, IGHE
39cyclosporin a44 28 5910.6LEP, MMP9, POMC, TRPV1, IGHE
40glutamate448.2LEP, MMP9, TRPV1, IGHE

GO Terms for genes affiliated with Sick Building Syndrome

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16Gene Ontology
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Cellular components related to Sick Building Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1LEP, MMP9, POMC, ITM2B
2extracellular regionGO:0055767.9LEP, MMP9, POMC, IGHE, ITM2B

Products for genes affiliated with Sick Building Syndrome

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Sources for Sick Building Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet