MCID: SCK001
MIFTS: 36

Sick Building Syndrome malady

Summaries for Sick Building Syndrome

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Indoor environmental quality (IEQ) refers to the quality of a building’s environment in relation to the health and wellbeing of those who occupy space within it.   IEQ is determined by many factors, including lighting, air quality, and damp conditions. Workers are often concerned that they have symptoms or health conditions from exposures to contaminants in the buildings where they work.  One reason for this concern is that their symptoms often get better when they are not in the building. While research has shown that some respiratory symptoms and illnesses can be associated with damp buildings, it is still unclear what measurements of indoor contaminants show that workers are at risk for disease.  In most instances where a worker and his or her physician suspect that the building environment is causing a specific health condition, the information available from medical tests and tests of the environment is not sufficient to establish which contaminants are responsible.  Despite uncertainty about what to measure and how to interpret what is measured, research shows that building-related symptoms are associated with building characteristics, including dampness, cleanliness, and ventilation characteristics.

MalaCards: Sick Building Syndrome is related to asthma and n syndrome. An important gene associated with Sick Building Syndrome is ITM2B (integral membrane protein 2B), and among its related pathways is Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds shu 9119 and alpha msh have been mentioned in the context of this disorder. Affiliated tissues include colon and endothelial, and related mouse phenotype tumorigenesis.

Disease Ontology:8 An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. the disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

Wikipedia:64 Sick building syndrome (SBS) is used to describe situations in which building occupants experience acute... more...

Aliases & Classifications for Sick Building Syndrome

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

sick building syndrome 8 10 61


External Ids:

Disease Ontology8 DOID:2710
SNOMED-CT57 19076009
MeSH35 D018877

Related Diseases for Sick Building Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sick Building Syndrome:



Diseases related to sick building syndrome

Clinical Features for Sick Building Syndrome

Drugs & Therapeutics for Sick Building Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Sick Building Syndrome

Drug clinical trials:

Search ClinicalTrials for Sick Building Syndrome

Search NIH Clinical Center for Sick Building Syndrome

Search CenterWatch for Sick Building Syndrome

Genetic Tests for Sick Building Syndrome

Anatomical Context for Sick Building Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Sick Building Syndrome:

33
Colon, Endothelial

Animal Models for Sick Building Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Sick Building Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0LEP, MMP9, POMC, TRPV1

Publications for Sick Building Syndrome

Sources:
51PubMed
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Articles related to Sick Building Syndrome:

(show top 50)    (show all 196)
idTitleAuthorsYear
1
Sick Building Syndrome and autoimmunity. (21300685)
2011
2
The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants. (21188456)
2011
3
Sick building syndrome in relation to domestic exposure in Sweden--a cohort study from 1991 to 2001. (19850651)
2010
4
A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. (19608217)
2009
5
Molds, mycotoxins, and sick building syndrome. (19854820)
2009
6
Sick building syndrome in relation to air exchange rate, CO(2), room temperature and relative air humidity in university computer classrooms: an experimental study. (18246367)
2008
7
The sick building syndrome: a chicken and egg situation? (16408193)
2006
8
No consistent risk factor pattern for symptoms related to the sick building syndrome: a prospective population based study. (16404637)
2006
9
Associations among sick building syndrome, psychosocial factors, and personality traits. (16060437)
2005
10
Bioaerosols and sick building syndrome: particles, inflammation, and allergy. (15764903)
2005
11
A time-series study of sick building syndrome: chronic, biotoxin-associated illness from exposure to water-damaged buildings. (15681119)
2005
12
Effect of chlorine dioxide gas on fungi and mycotoxins associated with sick building syndrome. (16151130)
2005
13
The roles of Penicillium and Aspergillus in sick building syndrome. (15350796)
2004
14
Culturability and toxicity of sick building syndrome-related fungi over time. (15238302)
2004
15
Sick building syndrome. (14739390)
2004
16
Multiple logistic regression modelling substantiates multifactor contributions associated with sick building syndrome in residential interiors in Mauritius. (12745349)
2003
17
Environmental tobacco smoke exposure and overtime work as risk factors for sick building syndrome in Japan. (11682362)
2001
18
The effects of outdoor air supply rate in an office on perceived air quality, sick building syndrome (SBS) symptoms and productivity. (11089327)
2000
19
Development of a multiple regression model to identify multi-family residential buildings with a high prevalence of sick building syndrome (SBS). (11980099)
2000
20
The sick building syndrome. (10598396)
1999
21
The sick building syndrome as a subjective perception-theoretical approach and assessment methods. (10507132)
1999
22
Continually measured fungal profiles in sick building syndrome. (9841779)
1999
23
Sick building syndrome in an office building formerly used by a pharmaceutical company: a case study. (10390939)
1999
24
Perceived air quality, sick building syndrome (SBS) symptoms and productivity in an office with two different pollution loads. (10439554)
1999
25
The sick building syndrome: a diagnostic dilemma. (9783873)
1998
26
The sick building syndrome: a danger to your health. (9763770)
1998
27
The natural history of concurrent sick building syndrome and chronic fatigue syndrome. (9201647)
1997
28
Sick-building syndrome. (9217781)
1997
29
Sick-building syndrome in a tropical city. (8622382)
1996
30
Molds, fungi cause sick building syndrome. (8570119)
1996
31
Sick building syndrome and gender bias: imperiling women's health. (7747241)
1995
32
The sick building syndrome and mass hysteria. (7643833)
1995
33
Do microbes contribute to sick building syndrome? (22667235)
1995
34
The Sick Building Syndrome (SBS) in office workers. A case-referent study of personal, psychosocial and building-related risk indicators. (7721522)
1994
35
Concurrent sick building syndrome and chronic fatigue syndrome: epidemic neuromyasthenia revisited. (8148452)
1994
36
An investigation into sick building syndrome among local authority employees. (7978993)
1994
37
Effect of air humidification on the sick building syndrome and perceived indoor air quality in hospitals: a four month longitudinal study. (8000493)
1994
38
The sick building syndrome. I. Definition and epidemiological considerations. (8331040)
1993
39
Sick building syndrome in a Canadian office complex. (8215593)
1993
40
Serum myeloperoxidase and sick building syndrome. (8100878)
1993
41
Sick building syndrome. (8332160)
1993
42
High prevalence of sick building syndrome in a new air-conditioned building in Italy. (1539998)
1992
43
Sick building syndrome. Medical evaluation of two work forces. (1464788)
1992
44
Controlled experiments for studies of the sick building syndrome. (1580480)
1992
45
Sick building syndrome and sinusitis. (1346208)
1992
46
The role of psychological factors in the report of building-related symptoms in sick building syndrome. (1592950)
1992
47
Sick building syndrome. (1986430)
1991
48
Influence of indoor climate on the sick building syndrome in an office environment. The Danish Indoor Climate Study Group. (2255877)
1990
49
Problem buildings: building-associated illness and the sick building syndrome. (2603079)
1989
50
The sick building syndrome. (3917804)
1985

Genetic Variations for Sick Building Syndrome

Expression for genes affiliated with Sick Building Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Building Syndrome

Search GEO for disease gene expression data for Sick Building Syndrome.

Pathways for genes affiliated with Sick Building Syndrome

Sources:
12EMD Millipore
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Pathways related to Sick Building Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development Leptin signaling via JAK/STAT and MAPK cascades
Hide members
9.7LEP, POMC

Compounds for genes affiliated with Sick Building Syndrome

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB
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Compounds related to Sick Building Syndrome according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1shu 911945 6011.1LEP, POMC
2alpha msh4510.1LEP, POMC
3megestrol acetate4510.1LEP, POMC
4topiramate45 11 2412.1LEP, POMC
5thiopental45 1111.1LEP, POMC
6fenfluramine29 45 1112.1POMC, LEP
7cortisone45 2411.1LEP, POMC
88-isoprostane459.8LEP, MMP9
9formaldehyde45 2410.8TRPV1, POMC, MMP9
10anandamide45 29 60 2412.7LEP, TRPV1
11beclomethasone dipropionate459.7IGHE, POMC
1211beta-hydroxysteroid459.6POMC, LEP
13heroin45 50 1111.6POMC, IGHE
14gnrh459.5RGS3, LEP, POMC
15gaba459.4TRPV1, POMC, MMP9, LEP
16lidocaine45 29 1111.4TRPV1, IGHE
17fluticasone propionate45 50 60 1112.4MMP9, POMC, IGHE
18budesonide45 50 1111.3IGHE, POMC, LEP
19propofol45 50 1111.3POMC, IGHE
20capsaicin45 2910.3LEP, TRPV1, IGHE
21thyroxine45 2410.3LEP, POMC, IGHE
22l-nmma459.3LEP, MMP9, IGHE
23glycerol45 11 2411.2LEP, POMC, IGHE
24vitamin a45 11 2411.2LEP, MMP9, IGHE
25methotrexate45 50 1111.1IGHE, MMP9, LEP
26ascorbic acid45 2410.1LEP, POMC, IGHE
27n acetylcysteine459.1IGHE, MMP9, LEP
28indomethacin45 60 29 1112.1IGHE, POMC, LEP
29adenylate459.0IGHE, TRPV1, POMC, MMP9
30epinephrine45 11 2411.0IGHE, POMC, MMP9, LEP
31inositol458.9IGHE, TRPV1, MMP9, LEP
32nicotine45 50 29 1111.9LEP, MMP9, TRPV1, IGHE
33norepinephrine45 11 2410.9IGHE, POMC, MMP9, LEP
34creatinine458.9IGHE, POMC, MMP9, LEP
35cycloheximide458.9LEP, MMP9, POMC, IGHE
36testosterone45 60 11 2411.9IGHE, POMC, MMP9, LEP
37dexamethasone45 50 29 1111.8IGHE, POMC, MMP9, LEP
38vegf458.8LEP, MMP9, POMC, IGHE
39cyclosporin a45 29 6010.6LEP, MMP9, POMC, TRPV1, IGHE
40glutamate458.2LEP, MMP9, TRPV1, IGHE

GO Terms for genes affiliated with Sick Building Syndrome

Sources:
16Gene Ontology
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Cellular components related to Sick Building Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1LEP, MMP9, POMC, ITM2B
2extracellular regionGO:0055767.9LEP, MMP9, POMC, IGHE, ITM2B

Products for genes affiliated with Sick Building Syndrome

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Sources for Sick Building Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet