MCID: SCK001

Sick Building Syndrome malady

Summaries for Sick Building Syndrome

Sources:
6Disease Ontology, 2CDC, 44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
Disease Ontology: An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. the disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.6

MalaCards: Sick Building Syndrome, also known as sick building syndrome (disorder), is related to vernal keratoconjunctivitis and hyper-ige syndrome. An important gene associated with Sick Building Syndrome is MT1DP (metallothionein 1D, pseudogene), and among its related pathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds beclomethasone dipropionate and lidocaine have been mentioned in the context of this disorder. Related mouse phenotype tumorigenesis.

CDC: NIOSH Alert: Preventing Occupational Respiratory Disease from Exposures Caused by Dampness in Office Buildings, Schools, and Other Nonindustrial BuildingsDHHS (NIOSH) Publication No. 2013-102 (November 2012)2

Wikipedia: Sick building syndrome (SBS) is a combination of ailments associated with an individual\'s place of work...44 more...

Aliases & Descriptions for Sick Building Syndrome

Sources:
2CDC, 6Disease Ontology, 8DISEASES, 43UMLS, 24MeSH, 40SNOMED-CT
See all sources

Aliases & Descriptions:

sick building syndrome 6 8 43
sick building syndrome (disorder) 6

External Ids:

SNOMED-CT40 19076009

Related Diseases for Sick Building Syndrome

Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to sick building syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1vernal keratoconjunctivitis12.9MMP9, IGHE
2hyper-ige syndrome12.8MMP9, IGHE
3acute pyelonephritis12.7POMC, MMP9
4pulmonary alveolar proteinosis12.7MMP9, IGHE
5adrenal gland hyperfunction12.5POMC, LEP
6familial male-limited precocious puberty12.4POMC, LEP
7neuroectodermal endocrine syndrome12.4POMC, LEP
8short bowel syndrome12.4LEP, IGHE
9functioning pituitary adenoma12.4LEP, POMC
10congestive heart failure12.3MMP9, TRPV1, POMC
11gynecomastia12.2LEP, POMC
1221-hydroxylase deficiency12.2LEP, POMC
13bronchial asthma12.0MMP9, LEP, IGHE
14acute pancreatitis12.0MMP9, LEP, IGHE
15growth hormone deficiency12.0LEP, MMP9, POMC
16photosensitive trichothiodystrophy12.0POMC, IGHE, LEP
17acne11.9MMP9, LEP, POMC
18traumatic brain injury11.9POMC, MMP9, LEP
19neurodegeneration11.9MMP9, ITM2B, TRPV1, POMC
20spinal cord injury11.9LEP, POMC, MMP9
21hyperthyroidism11.9IGHE, POMC, LEP
22purpura11.9LEP, IGHE, MMP9
23congenital heart defect11.9POMC, LEP, MMP9
24vaginitis11.9IGHE, LEP, MMP9
25skin disease11.8POMC, IGHE, MMP9
26sinusitis11.8POMC, IGHE, MMP9
27hypothyroidism11.8POMC, LEP, IGHE
28virilization11.7POMC, LEP
29alcohol dependence11.7LEP, MMP9, POMC
30brain injury11.6POMC, LEP, MMP9
31gastritis11.6LEP, IGHE, TRPV1, MMP9
32allergic rhinitis11.6TRPV1, LEP, MMP9, IGHE
33rhinitis11.6TRPV1, IGHE, MMP9, LEP
34migraine without aura11.6TRPV1, IGHE, MMP9, LEP
35duodenitis11.6MMP9, LEP, TRPV1, IGHE
36myopathy11.6LEP, MT1DP, MMP9, POMC
37pertussis11.6LEP, POMC, RGS3, IGHE
38peritonitis11.5MMP9, IGHE, LEP, TRPV1
39pulmonary tuberculosis11.5POMC, MMP9, IGHE, LEP
40acute myocardial infarction11.4MMP9, IGHE, LEP, POMC
41coronary heart disease11.4LEP, MMP9, POMC, IGHE
42neuropathy11.4POMC, TRPV1, LEP, MMP9
43blindness11.4MMP9, IGHE, POMC, LEP
44primary hyperoxaluria11.4LEP, MMP9, TRPV1, POMC
45pulmonary disease11.4TRPV1, IGHE, MMP9, LEP
46crohn's disease11.3MMP9, IGHE, LEP, POMC
47cystic fibrosis11.3DERL1, IGHE, MMP9, RGS3, LEP
48fibrosis11.3RGS3, MMP9, DERL1, IGHE, LEP
49irritable bowel syndrome11.2LEP, IGHE, POMC, ITM2B, TRPV1
50inflammatory bowel disease11.1LEP, TRPV1, POMC, MMP9, ITM2B

Graphical network of the top 20 diseases related to sick building syndrome:



Graphical network of diseases related to sick building syndrome

Clinical Features for Sick Building Syndrome

Drugs & Therapeutics for Sick Building Syndrome

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for sick building syndrome

Drug clinical trials:

Search ClinicalTrials for sick building syndrome

Search NIH Clinical Center for sick building syndrome

Search CenterWatch for sick building syndrome

Genetic Tests for Sick Building Syndrome

Anatomical Context for Sick Building Syndrome

Phenotypes for genes affiliated with Sick Building Syndrome

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to sick building syndrome:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1tumorigenesisMP:00020068.1LEP, MMP9, TRPV1, POMC

Publications for genes affiliated with Sick Building Syndrome

Sources:
35PubMed
See all sources

Articles related to sick building syndrome:

idTitleAuthorsYearAffiliating Genes
1Sick building syndrome (SBS) and exposure to water-damaged buildings: time series study, clinical trial and mechanisms. (17010568)Shoemaker R.C.... House D.E.2006MMP9, POMC, LEP

Expression for genes affiliated with Sick Building Syndrome

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Sick Building Syndrome

Pathways for genes affiliated with Sick Building Syndrome

Sources:
41Thomson Reuters, 10EMD Millipore
See all sources

Pathways related to sick building syndrome according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1Development_Leptin signaling via JAK/STAT and MAPK cascades419.0LEP, POMC
2Development Leptin signaling via JAK/STAT and MAPK cascades108.7LEP, POMC

Compounds for genes affiliated with Sick Building Syndrome

Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to sick building syndrome according to GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1beclomethasone dipropionate32 9.7POMC, IGHE
2lidocaine32 9 9 11.6IGHE, TRPV1
3heroin32 9 9 11.6IGHE, POMC
4anandamide32 18 10.4TRPV1, LEP
5alpha msh32 9.4LEP, POMC
6megestrol acetate32 9.4LEP, POMC
7topiramate32 42 9 18 9 13.4LEP, POMC
8thiopental32 9 9 11.4LEP, POMC
9fenfluramine32 9 9 11.4LEP, POMC
10cortisone32 18 10.3LEP, POMC
11formaldehyde32 18 10.2POMC, TRPV1, MMP9
12fluticasone propionate32 42 9 9 12.2POMC, IGHE, MMP9
13capsaicin32 9.1TRPV1, IGHE, LEP
14propofol32 9 9 11.0IGHE, POMC
1511beta-hydroxysteroid32 9.0LEP, POMC
168-isoprostane32 9.0LEP, MMP9
17l-nmma32 9.0IGHE, MMP9, LEP
18budesonide32 42 9 9 11.9LEP, IGHE, POMC
19vitamin a32 9 18 9 11.9IGHE, MMP9, LEP
20thyroxine32 18 9.9LEP, IGHE, POMC
21methotrexate32 34 42 9 9 12.9IGHE, MMP9, LEP
22gnrh32 8.9LEP, POMC, RGS3
23glycerol32 9 18 9 11.8POMC, IGHE, LEP
24n acetylcysteine32 8.7IGHE, MMP9, LEP
25adenylate32 8.7MMP9, IGHE, TRPV1, POMC
26indomethacin32 9 9 10.6LEP, IGHE, POMC
27inositol32 8.6TRPV1, IGHE, MMP9, LEP
28ascorbic acid32 18 9.5POMC, IGHE, LEP
29gaba32 42 9.5LEP, MMP9, TRPV1, POMC
30epinephrine32 9 18 9 11.4LEP, MMP9, IGHE, POMC
31norepinephrine32 9 18 9 11.4LEP, MMP9, IGHE, POMC
32creatinine32 8.4POMC, IGHE, MMP9, LEP
33cycloheximide32 8.3POMC, IGHE, MMP9, LEP
34testosterone32 9 18 9 11.3LEP, MMP9, IGHE, POMC
35dexamethasone32 42 34 9 9 12.2LEP, MMP9, IGHE, POMC
36vegf32 8.2POMC, IGHE, MMP9, LEP
37cyclosporin a32 42 8.9LEP, MMP9, IGHE, TRPV1, POMC

GO Terms for genes affiliated with Sick Building Syndrome

Sources:
12Gene Ontology
See all sources

Cellular components related to sick building syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1LEP, ITM2B, MMP9, POMC

Sources for Sick Building Syndrome

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS