SND
MCID: SCK002
MIFTS: 56

Sick Sinus Syndrome (SND) malady

Genetic diseases, Cardiovascular diseases, Rare diseases categories

Summaries for Sick Sinus Syndrome

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22Genetics Home Reference, 66Wikipedia, 34MalaCards
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Genetics Home Reference:22 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards: Sick Sinus Syndrome, also known as sinus node dysfunction, is related to atrioventricular block and sick sinus syndrome 2. An important gene associated with Sick Sinus Syndrome is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are Cardiac Progenitor Differentiation and Cardiomyocyte Differentiation through BMP Receptors. The compounds p00035 and hncs have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related mouse phenotypes are muscle and normal.

Wikipedia:66 Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of... more...

Aliases & Classifications for Sick Sinus Syndrome

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9Disease Ontology, 22Genetics Home Reference, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

sick sinus syndrome 9 22 11 46 63
sinus node dysfunction 22 63
sinus node disease 22
snd 22
sss 22


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Disease Ontology9 DOID:13884
MeSH36 D012804
NCIt41 C62244
ICD1026 I49.5

Related Diseases for Sick Sinus Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Sick Sinus Syndrome 2 family:

sick sinus syndrome Sick Sinus Syndrome 1
Sick Sinus Syndrome 3

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1atrioventricular block31.1NPPB, SCN5A
2sick sinus syndrome 230.9HCN4
3brugada syndrome30.8SCN5A, HCN4
4congenital heart disease30.5NPPA, NPPB
5myocardial infarction30.4AGT, NPPA, NPPB
6coronary artery disease30.2AGT, NPPB, NPPA
7acute myocardial infarction30.2AGT, NPPA, NPPB
8diabetes mellitus30.2NPPA, CYP27B1, AGT, NPPB
9syncope10.8
10amyloidosis10.6
11sick sinus syndrome 110.5
12sick sinus syndrome 310.4
13thyrotoxicosis10.4
14isolated levocardia10.4
15sick sinus syndrome 2, autosomal dominant10.4
16sick sinus syndrome 1, autosomal recessive10.4
17sinus node disease and myopia10.4
18dextrocardia10.3
19parkinson's disease10.3
20artery disease10.3
21myotonic dystrophy10.3
22pericarditis10.3
23polymyositis10.3
24thromboembolism10.3
25levocardia10.3
26erdheim-chester disease10.2
27inferior myocardial infarction10.2
28systemic lupus erythematosus10.2
29lupus erythematosus10.2
30catecholaminergic polymorphic ventricular tachycardia10.2
31left ventricular noncompaction10.2
32limbic encephalitis10.2
33arteriovenous fistula10.1
34acromegaly10.1
35conduct disorder10.1
36alzheimer's disease10.1
37situs inversus10.1
38hypertrophic cardiomyopathy10.1
39infertility10.1
40arrhythmogenic right ventricular dysplasia10.1
41ritter's disease10.1
42glossopharyngeal neuralgia10.1
43typhoid fever10.1
44ebstein anomaly10.1
45cataract10.1
46cervicitis10.1
47encephalitis10.1
48esophagitis10.1
49herpes simplex10.1
50hyperthyroidism10.1

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to sick sinus syndrome

Symptoms for Sick Sinus Syndrome

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Drugs & Therapeutics for Sick Sinus Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Sick Sinus Syndrome

Search CenterWatch for Sick Sinus Syndrome

Genetic Tests for Sick Sinus Syndrome

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Anatomical Context for Sick Sinus Syndrome

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34MalaCards
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MalaCards organs/tissues related to Sick Sinus Syndrome:

34
Heart, Testes, Atrioventricular node, Spleen, Brain, B cells

Animal Models for Sick Sinus Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Sick Sinus Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7HCN4, SCN5A, MYH6, NPPA, NPPB, AGT
2MP:00028738.5PODXL, SCN5A, HCN4, HCN1, F2
3MP:00053767.9F2, CYP27B1, HCN4, PODXL, MYH6, NPPA
4MP:00107687.7F2, HCN2, HCN4, SCN5A, PODXL, MYH6
5MP:00036317.2F2, HCN1, HCN2, HCN3, SCN5A, PODXL
6MP:00053855.4AGT, F2, HCN1, HCN2, HCN3, HCN4

Publications for Sick Sinus Syndrome

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Sources:
53PubMed
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Articles related to Sick Sinus Syndrome:

(show top 50)    (show all 485)
idTitleAuthorsYear
1
Isolated cardiac involvement in primary amyloidosis: presenting as sick sinus syndrome and heart failure. (24391340)
2013
2
Left atrial responses to acute right ventricular apical pacing in patients with sick sinus syndrome. (23822568)
2013
3
Sick sinus syndrome in a dog: treatment with dual-chambered pacemaker implantation. (23115373)
2012
4
Sick sinus syndrome associated with topical timolol maleate instillation. (22025865)
2011
5
Not so fast! Sick sinus syndrome is a complex and incompletely understood disease that might prove hard to model in animals. (21791463)
2011
6
Congenital sick sinus syndrome with atrial inexcitability and coronary sinus flutter. (22010118)
2011
7
Sick sinus syndrome with Alzheimer's disease for bilateral hernia repair. (21772702)
2011
8
Prevalence of the Brugada-type electrocardiogram and incidence of Brugada syndrome in patients with sick sinus syndrome. (20019410)
2010
9
Atrial size independently correlates with the development of paroxysmal atrial fibrillation in patients with sick sinus syndrome. (21199611)
2010
10
A patient with sick sinus syndrome, atrial flutter and bidirectional ventricular tachycardia: Coincident or concomitant presentations? (18651526)
2007
11
I was recently diagnosed with sick sinus syndrome. What is this exactly, and is it a serious condition? (17387777)
2007
12
Role of the low amplitude potential in the initial P wave signal-averaged electrocardiogram [corrected] in sick sinus syndrome. (16864929)
2006
13
Isolated noncompaction of left ventricular myocardium with fetal sustained bradycardia due to sick sinus syndrome. (17290580)
2006
14
A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. (15910881)
2005
15
Ebstein anomaly associated with unusual conduction delay and sick sinus syndrome. (15226641)
2004
16
Familial sick sinus syndrome complicated by extensive cardiac conduction disturbance. (15094010)
2004
17
Blood pressure variability in paced patients with sick sinus syndrome. (11918152)
2002
18
Physiologic atrial cardiac pacing for the prevention of chronic atrial fibrillation associated with sick sinus syndrome. (11814087)
2002
19
Regional myocardial blood flow in patients with sick sinus syndrome randomized to long-term single chamber atrial or dual chamber pacing--effect of pacing mode and rate. (10807447)
2000
20
Stroke in paced patients with sick sinus syndrome: influence of left atrial function and size. (10516407)
1999
21
AAI pacing for sick sinus syndrome: first choice on all counts. (9875100)
1998
22
Prospective randomised trial of atrial versus ventricular pacing in sick-sinus syndrome. (7983951)
1994
23
Atrial adaptive rate pacing in sick sinus syndrome: effects on exercise capacity and arrhythmias. (8435244)
1993
24
Update on sick sinus syndrome, a cardiac disorder of aging. (2403955)
1990
25
Sick sinus syndrome as a complication of mediastinal radiation therapy. (2337864)
1990
26
Cardiac electrophysiologic properties of intravenous isradipine in patients with sick sinus syndrome. (2523662)
1989
27
Long-term follow-up of patients with sick sinus syndrome: a comparison of clinical aspects among unpaced, ventricular inhibited paced, and physiologically paced groups. (2462243)
1988
28
Syncope in the elderly. Report of 3 cases with sick sinus syndrome. (3704847)
1986
29
Sick sinus syndrome: adenosine mediated? (2860359)
1985
30
Sick sinus syndrome: the role of hypervagotonia. (6724752)
1984
31
Suspected sick sinus syndrome in an infant treated by pacemaker implantation. (6473126)
1984
32
Pacemaker treatment of sick sinus syndrome in children. (6833672)
1983
33
Comparative evaluation of depressed automaticity in sick sinus syndrome by Holter monitoring and overdrive suppression test. (6682281)
1983
34
Sinoatrial arrest due to lidocaine injection in sick sinus syndrome during amiodarone administration. (7148661)
1982
35
Polymyositis presenting as sick sinus syndrome. (7122376)
1982
36
A clinicopathologic study on sick sinus syndrome with histological approach to the sinoatrial node. (7401276)
1980
37
Effect of verapamil on normal sinoatrial node function and on sick sinus syndrome. (717239)
1978
38
The sick sinus syndrome. A study of 50 cases. (621450)
1978
39
Symptomatic improvement in a patient with sick sinus syndrome after the onset of stable atrial flutter. (95640)
1978
40
Sick sinus syndrome due to cardiac amyloidosis. (657173)
1978
41
A case of supraventricular tachycardia in an infant probably due to sick sinus syndrome. (913311)
1977
42
Treatment of sick sinus syndrome with permanent cardiac pacemaker. (Sick sinus syndrome and artificial pacemaker). (591551)
1977
43
Clinical spectrum of the sick sinus syndrome. (836172)
1977
44
Sick sinus syndrome. (1047966)
1976
45
First-degree sinoatrial heart block: sinoatrial block in the sick-sinus syndrome. (1258728)
1976
46
"Paradoxical" prolongation of sinus nodal recovery time after atropine in the sick sinus syndrome. (1146702)
1975
47
Sick sinus syndrome. Symptomatic cases in children. (1211960)
1975
48
Letter: Sick sinus syndrome. (1174896)
1975
49
Sick sinus syndrome: experience of a cardiac pacemaker clinic. (4415767)
1974
50
Appraisal of sinus nodal recovery time in patients with sick sinus syndrome. (4850629)
1974

Variations for Sick Sinus Syndrome

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Sick Sinus Syndrome:

1
id Gene Name Type Significance SNP ID Assembly Location
1SCN5ANM_000335.4(SCN5A): c.5347G> A (p.Glu1783Lys)single nucleotide variantPathogenicrs137854601GRCh37Chr 3, 38592513: 38592513
2SCN5ANM_000335.4(SCN5A): c.3890C> T (p.Pro1297Leu)single nucleotide variantPathogenicrs28937319GRCh37Chr 3, 38603976: 38603976

Expression for genes affiliated with Sick Sinus Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for genes affiliated with Sick Sinus Syndrome

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 52PharmGKB, 56Reactome, 13EMD Millipore
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Pathways related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SCN5A, MYH6
29.8NPPA, NPPB
39.6HCN4, SCN5A, HCN2
49.4NPPA, AGT, NPPB
5
Show member pathways
8.5HCN1, HCN2, HCN3, HCN4
68.5HCN3, HCN2, HCN1, HCN4
7
Show member pathways
8.5HCN3, HCN4, HCN1, HCN2
8
Show member pathways
8.3HCN3, SCN5A, HCN4, HCN2, HCN1
9
Show member pathways
8.3HCN3, HCN2, HCN1, HCN4, MYH6

Compounds for genes affiliated with Sick Sinus Syndrome

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1p000354610.2NPPA, NPPB
2hncs4610.2NPPA, NPPB
3candoxatril46 1211.2NPPA, NPPB
4alacepril4610.1NPPA, NPPB
5ly 835834610.1AGT, NPPA
6imidapril46 5211.1NPPA, NPPB
7urodilatin4610.1NPPB, NPPA
8hanp4610.1NPPA, NPPB
9bisoprolol46 52 1212.0NPPB, NPPA
10inulin4610.0NPPA, AGT
11trandolapril46 1211.0NPPB, NPPA
12moxonidine469.8NPPA, NPPB
13enalaprilat469.8AGT, NPPB, NPPA
14lisinopril46 52 25 1212.8NPPA, NPPB, AGT
158-bromo cgmp469.8AGT, NPPA, NPPB
16perindopril46 52 1211.8NPPA, AGT, NPPB
17enalapril46 52 1211.8AGT, NPPB, NPPA
18amlodipine46 52 25 1212.8AGT, NPPB, NPPA
19captopril46 62 52 30 1213.8AGT, NPPA, NPPB
20ang ii469.8AGT, NPPB, NPPA
21l-nmma469.8NPPB, NPPA, AGT
22dobutamine46 30 52 1212.8NPPB, NPPA
23phenylephrine46 30 25 1212.8NPPA, NPPB, AGT
24losartan46 52 30 1212.7NPPB, NPPA, AGT
25hydroxyethyl starch469.7NPPA, F2
26digoxin46 62 52 25 1213.7NPPB, NPPA, F2
27haloperidol46 52 30 3 1213.7NPPB, AGT, NPPA
28fosinopril46 1210.7NPPA, NPPB
29aprotinin46 1210.6NPPB, F2, AGT
30guanylate469.6AGT, NPPA, NPPB
31isoproterenol46 1210.5NPPB, MYH6, AGT, NPPA
32benazepril46 52 1211.5NPPA, AGT
33norepinephrine46 25 1211.5AGT, NPPA, MYH6, NPPB
34homocysteine46 2510.5F2, NPPB, AGT
35estradiol46 25 1211.4CYP27B1, NPPB, AGT, MYH6
36forskolin46 52 1211.4NPPB, CYP27B1, NPPA, AGT
37potassium46 25 1211.4AGT, NPPA, HCN2, HCN4, SCN5A
38epinephrine46 25 1211.3NPPA, F2, AGT, NPPB
39arginine469.2AGT, NPPB, NPPA, MYH6, SCN5A
40cyclosporin a46 30 6211.2F2, NPPB, AGT, NPPA
41pge2469.2AGT, CYP27B1, NPPA, NPPB
42oxygen46 2510.0NPPA, MYH6, CYP27B1, AGT, NPPB
43ivabradine309.0HCN4, HCN1, HCN2, HCN3
44zatebradine309.0HCN1, HCN2, HCN3, HCN4
45cilobradine309.0HCN4, HCN3, HCN2, HCN1
46zd7288309.0HCN4, HCN3, HCN1, HCN2
47cs+309.0HCN1, HCN4, HCN3, HCN2
48estrogen468.9F2, CYP27B1, MYH6, NPPB, NPPA
49cyclic amp46 259.3HCN4, NPPA, HCN3, HCN2, HCN1, CYP27B1
50sodium46 258.6AGT, SCN5A, NPPA, HCN1, NPPB, HCN4

GO Terms for genes affiliated with Sick Sinus Syndrome

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17Gene Ontology
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Cellular components related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.0PODXL, HCN4, HCN3, HCN2, HCN1
2plasma membraneGO:0058866.4RGS6, F2, HCN1, HCN2, HCN3, HCN4

Biological processes related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cellular response to cGMPGO:07132110.1HCN2, HCN4
2cGMP biosynthetic processGO:0061829.9NPPB, NPPA
3regulation of heart rateGO:0020279.9HCN4, SCN5A, MYH6
4receptor guanylyl cyclase signaling pathwayGO:0071689.8NPPB, NPPA
5regulation of blood vessel sizeGO:0508809.8NPPA, NPPB
6regulation of blood pressureGO:0082179.7NPPB, NPPA, MYH6
7positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6AGT, F2
8positive regulation of renal sodium excretionGO:0358159.6NPPB, AGT
9positive regulation of reactive oxygen species metabolic processGO:20003799.3AGT, F2
10negative regulation of cell growthGO:0303089.3AGT, NPPB, NPPA, CYP27B1
11cellular response to cAMPGO:0713208.8HCN1, HCN2, HCN3, HCN4
12potassium ion transmembrane transportGO:0718058.8HCN1, HCN2, HCN3, HCN4
13regulation of membrane potentialGO:0423918.8HCN1, HCN2, HCN3, HCN4
14synaptic transmissionGO:0072688.6HCN1, HCN2, HCN3, HCN4
15sodium ion transmembrane transportGO:0357258.6SCN5A, HCN4, HCN3, HCN2, HCN1

Molecular functions related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3F2, NPPA, NPPB
2intracellular cAMP activated cation channel activityGO:0052229.3HCN1, HCN4, HCN2
3hormone activityGO:0051799.1NPPB, NPPA, AGT
4cAMP bindingGO:0305528.6HCN2, HCN3, HCN4, HCN1
5voltage-gated potassium channel activityGO:0052498.5HCN3, HCN1, HCN2, HCN4
6voltage-gated sodium channel activityGO:0052488.4HCN3, HCN1, HCN2, HCN4, SCN5A

Products for genes affiliated with Sick Sinus Syndrome

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  • Antibodies
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Sources for Sick Sinus Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet