MCID: SCK002
MIFTS: 53

Sick Sinus Syndrome

Categories: Cardiovascular diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Sick Sinus Syndrome

MalaCards integrated aliases for Sick Sinus Syndrome:

Name: Sick Sinus Syndrome 12 24 36 28 51 41 14 69
Sinus Node Dysfunction 24 69
Sinus Node Disease 24 28
Sinus Node Infection 12
Sss 24
Snd 24

Classifications:



External Ids:

Disease Ontology 12 DOID:13884
ICD10 32 I49.5
MeSH 41 D012804
NCIt 46 C62244
KEGG 36 H00729

Summaries for Sick Sinus Syndrome

Genetics Home Reference : 24 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards based summary : Sick Sinus Syndrome, also known as sinus node dysfunction, is related to familial sick sinus syndrome and atrioventricular block. An important gene associated with Sick Sinus Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Adipogenesis. The drugs Amiodarone and Propafenone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are cardiovascular system and behavior/neurological

Wikipedia : 72 Sick sinus syndrome (SSS), also called sinus dysfunction, or sinoatrial node disease (\"SND\"), is a... more...

Related Diseases for Sick Sinus Syndrome

Diseases in the Sick Sinus Syndrome family:

Sick Sinus Syndrome 2 Sick Sinus Syndrome 1
Sick Sinus Syndrome 3 Familial Sick Sinus Syndrome

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 familial sick sinus syndrome 33.2 AGT HCN4 MYH6 SCN5A
2 atrioventricular block 30.6 HCN4 LMNA SCN5A
3 atrial heart septal defect 30.1 F2 MYH6
4 brugada syndrome 29.7 HCN4 RANGRF SCN5A
5 atrial fibrillation 29.7 AGT F2 HCN4 SCN5A SHOX2
6 heart disease 29.5 F2 LMNA MYH6 SCN5A
7 left ventricular noncompaction 29.3 HCN4 LMNA MYH6 SCN5A
8 sinoatrial node disease 29.2 HCN4 MYH6 SCN5A SHOX2
9 hypertrophic cardiomyopathy 29.2 LMNA MYH6 TGFB1
10 dilated cardiomyopathy 28.4 AGT LMNA MYH6 SCN5A TGFB1
11 sick sinus syndrome 1 12.5
12 sick sinus syndrome 3 12.5
13 sick sinus syndrome 2 12.5
14 isolated levocardia 11.4
15 chronic atrial and intestinal dysrhythmia 11.3
16 sinus node disease and myopia 11.1
17 cardiac arrhythmia, ankyrin-b-related 11.1
18 language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia 11.0
19 third-degree atrioventricular block 10.4 HCN4 SCN5A
20 syncope 10.4
21 long qt syndrome 9 10.3 HCN4 SCN5A
22 right bundle branch block 10.3 HCN4 SCN5A
23 second-degree atrioventricular block 10.3 HCN4 LMNA
24 prolapse of female genital organ 10.2 F2 LMNA
25 amyloidosis 10.1
26 cardiomyopathy, dilated, 1e 10.1 LMNA SCN5A
27 lymphoma 10.1
28 familial isolated dilated cardiomyopathy 10.1 MYH6 SCN5A
29 intrinsic cardiomyopathy 10.1 LMNA MYH6 SCN5A
30 giant hemangioma 10.0 F2 TGFB1
31 atrial standstill 1 10.0
32 aging 10.0
33 ascending cholangitis 10.0 F2 TGFB1
34 placental abruption 10.0 AGT F2
35 graves disease 1 10.0
36 dextrocardia 10.0
37 posterior urethral valves 9.9 AGT TGFB1
38 fibromuscular dysplasia 9.9 AGT TGFB1
39 ischemic optic neuropathy 9.9 AGT F2
40 microvascular complications of diabetes 3 9.9 AGT TGFB1
41 arteries, anomalies of 9.9
42 myocardial infarction 9.9
43 coronary artery anomaly 9.9
44 pericarditis 9.9
45 hyperthyroidism 9.9
46 myotonic dystrophy 9.9
47 polymyositis 9.9
48 levocardia 9.9
49 holt-oram syndrome 9.9 MYH6 SHOX2
50 alzheimer disease 9.7

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to Sick Sinus Syndrome

Symptoms & Phenotypes for Sick Sinus Syndrome

MGI Mouse Phenotypes related to Sick Sinus Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 AGT F2 HCN4 LMNA MYH6 SCN5A
2 behavior/neurological MP:0005386 9.91 TGFB1 AGT F2 LMNA MYH6 SCN5A
3 mortality/aging MP:0010768 9.81 AGT F2 HCN4 LMNA MYH6 SCN5A
4 digestive/alimentary MP:0005381 9.65 F2 LMNA SGO1 SHOX2 TGFB1
5 muscle MP:0005369 9.43 AGT HCN4 LMNA MYH6 SCN5A TGFB1
6 nervous system MP:0003631 9.17 AGT F2 HCN4 LMNA SCN5A SHOX2

Drugs & Therapeutics for Sick Sinus Syndrome

Drugs for Sick Sinus Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
2
Propafenone Approved Phase 4 54063-53-5 4932
3
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
4
Ethanol Approved Phase 4 64-17-5 702
5 Adrenergic Agents Phase 4
6 Adrenergic Antagonists Phase 4
7 Adrenergic beta-Antagonists Phase 4
8 Anti-Arrhythmia Agents Phase 4
9 Autonomic Agents Phase 4
10 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
12 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
13 Cytochrome P-450 CYP3A Inhibitors Phase 4
14 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
15 Diuretics, Potassium Sparing Phase 4
16 Neurotransmitter Agents Phase 4
17 Peripheral Nervous System Agents Phase 4
18 Potassium Channel Blockers Phase 4
19 Sodium Channel Blockers Phase 4
20 Sympatholytics Phase 4
21 Vasodilator Agents Phase 4
22
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 10909430 439542
23
Cephalexin Approved, Investigational, Vet_approved Phase 3 15686-71-2 27447
24
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
25
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
26
Ofloxacin Approved Phase 3 82419-36-1 4583
27 Anti-Bacterial Agents Phase 3
28 Antibiotics, Antitubercular Phase 3
29 Anti-Infective Agents Phase 3
30 Anti-Infective Agents, Local Phase 3
31 Antitubercular Agents Phase 3
32 Clindamycin palmitate Phase 3
33 Clindamycin phosphate Phase 3
34 Polymyxin B Phase 3
35 Polymyxins Phase 3
36 Renal Agents Phase 3
37 Topoisomerase Inhibitors Phase 3
38
Angiotensin II Approved, Investigational 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
39
Losartan Approved 114798-26-4 3961
40
Menthol Approved 2216-51-5 16666
41
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
42 tannic acid Approved, Nutraceutical
43 Angiotensinogen
44 Angiotensin II Type 1 Receptor Blockers
45 Angiotensin Receptor Antagonists
46 Antihypertensive Agents

Interventional clinical trials:

(show top 50) (show all 58)

# Name Status NCT ID Phase Drugs
1 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
2 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
3 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation Unknown status NCT00224341 Phase 4
4 Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation Unknown status NCT02145546 Phase 4 Amiodarone;Propafenone;Sotalol
5 Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation Completed NCT00161538 Phase 4
6 Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing Completed NCT00286858 Phase 4
7 Austria Study - Analysis of Difference Between Active and Passive Fixation Leads Completed NCT00180557 Phase 4
8 Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study) Completed NCT00664807 Phase 4
9 Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease Completed NCT01170611 Phase 4
10 Falls and Cardiovascular Events in Pacemaker Patients Completed NCT01037426 Phase 4
11 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
12 Syncope: Pacing or Recording in the Later Years Active, not recruiting NCT01423994 Phase 4
13 Virtual Clinic Pacemaker Follow-up Terminated NCT00475124 Phase 4
14 Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation Completed NCT02317068 Phase 3
15 Mode Selection Trial in Sinus Node Dysfunction (MOST) Completed NCT00000561 Phase 3
16 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
17 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
18 Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum Completed NCT01609738 Phase 1, Phase 2
19 Second Study on Cardio-neuromodulation in Humans Recruiting NCT02954666 Phase 2
20 RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome Unknown status NCT01477138
21 The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome Unknown status NCT01310920
22 The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome Unknown status NCT00647257 Losartan;Placebo
23 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
24 Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI) Unknown status NCT00785564
25 Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan Unknown status NCT00314223
26 Right Ventricular Lead Placement in a Pacemaker Population: Evaluation of Apical and Alternative Position Unknown status NCT01647490
27 A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction Unknown status NCT02027909
28 Minimizing Ventricular Pacing Unknown status NCT01611389
29 The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker Completed NCT03245996
30 Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study Completed NCT01528657
31 Right Ventricle (RV) Markers of Future Pacing Induced Ventricular Dysfunction - Pilot Completed NCT02198781
32 The Atrial High Rate Episodes in Pacemaker Patients Completed NCT00627328
33 Prospective Registry of Pacemaker Patients Concerning Percentage of Right Ventricular Pacing, LVEF and NYHA Class Completed NCT00292539
34 SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction Completed NCT00284830
35 To Pace or Not to Pace in Sinus Node Disease Completed NCT02485093
36 DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed NCT00478933
37 Evaluation of Pacemaker Algorithms to Avoid Unnecessary Right Ventricular Pacing Completed NCT01803217
38 Right Ventricular Outflow Tract Study Completed NCT01294839
39 Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode Completed NCT02586480
40 Ingenio Device Algorithm Study Completed NCT01441583
41 IES-ACap: Influence of Atrial Pulse Width in the Behaviour of ACap™ Confirm Algorithm. Completed NCT00832260
42 PANORAMA Observational Study Completed NCT00382525
43 Real Life Automatic Atrial Capture Device Control Completed NCT02400983
44 Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome. Recruiting NCT02034526
45 Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study Recruiting NCT02314897
46 Left Ventricular Pacing to Avoid Cardiac Enlargement Study Recruiting NCT01302717
47 Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady) Recruiting NCT01643707
48 AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR Intervals Recruiting NCT02154750
49 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation Recruiting NCT03118440
50 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Double-chamber Pacemaker Implantation Recruiting NCT03118427

Search NIH Clinical Center for Sick Sinus Syndrome

Cochrane evidence based reviews: sick sinus syndrome

Genetic Tests for Sick Sinus Syndrome

Genetic tests related to Sick Sinus Syndrome:

# Genetic test Affiliating Genes
1 Sick Sinus Syndrome 28
2 Sinus Node Disease 28

Anatomical Context for Sick Sinus Syndrome

MalaCards organs/tissues related to Sick Sinus Syndrome:

38
Heart, Testes, Atrioventricular Node, Brain, B Cells, Lung, Spleen

Publications for Sick Sinus Syndrome

Articles related to Sick Sinus Syndrome:

(show top 50) (show all 548)
# Title Authors Year
1
Congenital sick sinus syndrome: Prenatal diagnosis and postnatal follow-up. ( 28805625 )
2017
2
Sick sinus syndrome. ( 28644224 )
2017
3
Persistent Sick Sinus Syndrome in Scrub Typhus. ( 28500798 )
2017
4
Hyperthyroidism and sick sinus syndrome, a rare but challenging association: A study of three cases. ( 28891553 )
2017
5
Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. ( 28674041 )
2017
6
Clinical phenotype of HCN4-related sick sinus syndrome. ( 28213054 )
2017
7
An unexpected presentation of sick sinus syndrome: Isolated ventricular asystole. ( 28460803 )
2017
8
Complex regional pain syndrome induced by pacemaker implantation for sick sinus syndrome. ( 29255517 )
2017
9
Implantation of VVI pacemaker in a patient with dextrocardia, persistent left superior vena cava, and sick sinus syndrome: A case report. ( 28151908 )
2017
10
Value of Combining Left Atrial Diameter and Amino-terminal Pro-brain Natriuretic Peptide to the CHA2DS2-VASc Score for Predicting Stroke and Death in Patients with Sick Sinus Syndrome after Pacemaker Implantation. ( 28776540 )
2017
11
Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls. ( 28525326 )
2017
12
Seizure Triggered by Sick Sinus Syndrome. ( 29103011 )
2017
13
Transient sick sinus syndrome with complete atrioventricular block associated with ergonovine intake: A case report. ( 29095320 )
2017
14
A Functional Assay for Sick Sinus Syndrome Genetic Variants. ( 28803248 )
2017
15
Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction. ( 28104484 )
2017
16
Eleven-year trends of inpatient pacemaker implantation in patients diagnosed with sick sinus syndrome. ( 28471545 )
2017
17
The proportion of asymptomatic recurrence after catheter ablation of atrial fibrillation in patients with a pacemaker for sick sinus syndrome. ( 29192587 )
2017
18
Rhythm, Sick Sinus Syndrome ( 29261930 )
2017
19
Long term effects of cilostazol in a dog with sick sinus syndrome. ( 28458273 )
2017
20
Isolated Persistent Left Superior Vena Cava, Sick Sinus Syndrome, and Challenging Pacemaker Implantation. ( 28912977 )
2017
21
Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome. ( 26798387 )
2016
22
Transforming Growth Factor-I^1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein Level. ( 27380173 )
2016
23
Autosomal recessive atrial disease presenting with sick sinus syndrome (SSS), right atrial fibrosis and biatrial dilatation: Clinical impact of genetic diagnosis. ( 26828384 )
2016
24
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block. ( 26831068 )
2016
25
SEVERE AMIODARONE-INDUCED BRADICARDIA CONCEALES SICK SINUS SYNDROME: CASE REPORT. ( 27125081 )
2016
26
Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. ( 27182706 )
2016
27
Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002-2014). ( 27286907 )
2016
28
Single lead atrial vs. dual chamber pacing in sick sinus syndrome: extended register-based follow-up in the DANPACE trial. ( 28039212 )
2016
29
Novel Mutation in the I+-Myosin Heavy Chain Gene Is Associated With Sick Sinus Syndrome. ( 25717017 )
2015
30
Anaplastic lymphoma kinase-positive lung adenocarcinoma patient with development of sick sinus syndrome while on targeted treatment with crizotinib. ( 25922742 )
2015
31
Predictors of sick sinus syndrome in patients after successful radiofrequency catheter ablation of atrial flutter. ( 25510744 )
2015
32
Beneficial effects of losartan for prevention of paroxysmal atrial fibrillation in patients with sick sinus syndrome: analysis with memory function of pacemaker. ( 25787020 )
2015
33
ECG of the Month. Third-degree AV block with sick sinus syndrome. ( 25835165 )
2015
34
Stored intracardiac electrograms reveal patients with sick sinus syndrome frequently develop atrioventricular block. ( 25947003 )
2015
35
Sodium Hydroxide Pinpoint Pressing Permeation Method for the Animal Modeling of Sick Sinus Syndrome. ( 26118592 )
2015
36
Beware of Venous Anomalies in Young Patients with Sick Sinus Syndrome: A Report of Two Cases of Sick Sinus Syndrome with Systemic Venous Anomalies. ( 27326354 )
2015
37
Role of temporary pacing at the right ventricular outflow tract in anesthetic management of a patient with asymptomatic sick sinus syndrome. ( 26712989 )
2015
38
Elevated plasma norepinephrine level and sick sinus syndrome in patients with lone atrial fibrillation. ( 25968056 )
2015
39
Red blood cell distribution width and atrial fibrillation in patients with sick sinus syndrome. ( 26321105 )
2015
40
Effective Management of Atrioventricular Interval for Paroxysmal Atrial Fibrillation That Developed After DDDR Pacemaker Implantation in a Sick Sinus Syndrome Patient. ( 26370366 )
2015
41
Development of Atrioventricular Block and Diagnostic Value of Stored Electrograms in Patients With Sick Sinus Syndrome and Implanted Pacemaker. ( 25753690 )
2015
42
Sick sinus syndrome and atrial fibrillation in older persons - A view from the sinoatrial nodal myocyte. ( 25668431 )
2015
43
Combined Algorithm Using a Poor Increase in Inferior P-Wave Amplitude During Sympathetic Stimulation and Sinus Node Recovery Time for the Diagnosis of Sick Sinus Syndrome. ( 26289967 )
2015
44
Sick Sinus Syndrome. ( 26485000 )
2015
45
Dual-chamber pacemakers for treating symptomatic bradycardia due to sick sinus syndrome without atrioventricular block: a systematic review and economic evaluation. ( 26293406 )
2015
46
Sick sinus syndrome: synopsis. ( 25104520 )
2014
47
Genetic analysis in a family affected by sick sinus syndrome may reduce the sudden death risk in a young aspiring competitive athlete. ( 24295898 )
2014
48
A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation. ( 24582607 )
2014
49
The effectiveness of the atrial or atrio-ventricular stimulation for sick sinus syndrome in a long term observation. ( 25001847 )
2014
50
Syncope in paced patients with sick sinus syndrome from the DANPACE trial: incidence, predictors and prognostic implication. ( 24711481 )
2014

Variations for Sick Sinus Syndrome

ClinVar genetic disease variations for Sick Sinus Syndrome:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.5350G> A (p.Glu1784Lys) single nucleotide variant Pathogenic rs137854601 GRCh37 Chromosome 3, 38592513: 38592513
2 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh37 Chromosome 3, 38620907: 38620907
3 SCN5A NM_000335.4(SCN5A): c.3890C> T (p.Pro1297Leu) single nucleotide variant Pathogenic rs28937319 GRCh37 Chromosome 3, 38603976: 38603976

Expression for Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for Sick Sinus Syndrome

Pathways related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.67 LMNA MYH6 TGFB1
2 11.45 AGT LMNA TGFB1
3 10.88 HCN4 LMNA SCN5A
4 10.52 MYH6 SCN5A TGFB1

GO Terms for Sick Sinus Syndrome

Cellular components related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intercalated disc GO:0014704 8.96 RANGRF SCN5A
2 blood microparticle GO:0072562 8.8 AGT F2 TGFB1

Biological processes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of fibroblast proliferation GO:0048146 9.58 AGT TGFB1
2 regulation of postsynaptic membrane potential GO:0060078 9.58 HCN4 SCN5A
3 cardiac muscle contraction GO:0060048 9.57 MYH6 SCN5A
4 chondrocyte differentiation GO:0002062 9.56 SHOX2 TGFB1
5 regulation of heart rate by cardiac conduction GO:0086091 9.55 HCN4 SCN5A
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.54 AGT F2
7 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.52 MYH6 TGFB1
8 positive regulation of protein localization to nucleus GO:1900182 9.51 F2 TGFB1
9 positive regulation of collagen biosynthetic process GO:0032967 9.49 F2 TGFB1
10 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.48 AGT TGFB1
11 positive regulation of cellular protein metabolic process GO:0032270 9.46 AGT TGFB1
12 positive regulation of superoxide anion generation GO:0032930 9.43 AGT TGFB1
13 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.4 HCN4 SCN5A
14 regulation of sodium ion transmembrane transport GO:1902305 9.37 RANGRF SCN5A
15 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 9.32 HCN4 RANGRF
16 regulation of membrane depolarization GO:0003254 9.26 HCN4 RANGRF
17 SA node cell action potential GO:0086015 9.16 HCN4 SCN5A
18 regulation of heart rate GO:0002027 9.02 AGT HCN4 MYH6 RANGRF SCN5A
19 membrane depolarization during SA node cell action potential GO:0086046 8.96 HCN4 SCN5A

Molecular functions related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium channel activity GO:0005272 9.16 HCN4 SCN5A
2 voltage-gated sodium channel activity GO:0005248 8.96 HCN4 SCN5A
3 growth factor activity GO:0008083 8.8 AGT F2 TGFB1

Sources for Sick Sinus Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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