SND
MCID: SCK002
MIFTS: 56

Sick Sinus Syndrome (SND) malady

Genetic diseases, Cardiovascular diseases, Rare diseases categories
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Summaries for Sick Sinus Syndrome

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21Genetics Home Reference, 65Wikipedia, 33MalaCards
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Genetics Home Reference:21 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards: Sick Sinus Syndrome, also known as sinus node dysfunction, is related to atrioventricular block and sick sinus syndrome 2. An important gene associated with Sick Sinus Syndrome is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are Cardiac Progenitor Differentiation and Cardiomyocyte Differentiation through BMP Receptors. The compounds p00035 and hncs have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related mouse phenotypes are muscle and normal.

Wikipedia:65 Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of... more...

Aliases & Classifications for Sick Sinus Syndrome

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8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

sick sinus syndrome 8 21 10 45 62
sinus node dysfunction 21 62
sinus node disease 21
snd 21
sss 21


External Ids:

Disease Ontology8 DOID:13884
MeSH35 D012804
NCIt40 C62244
ICD1025 I49.5

Related Diseases for Sick Sinus Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Sick Sinus Syndrome 2 family:

sick sinus syndrome Sick Sinus Syndrome 1
Sick Sinus Syndrome 3

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1atrioventricular block31.1NPPB, SCN5A
2sick sinus syndrome 230.9HCN4
3brugada syndrome30.8SCN5A, HCN4
4congenital heart disease30.5NPPA, NPPB
5myocardial infarction30.4AGT, NPPA, NPPB
6coronary artery disease30.2AGT, NPPB, NPPA
7acute myocardial infarction30.2AGT, NPPA, NPPB
8diabetes mellitus30.2NPPA, CYP27B1, AGT, NPPB
9syncope10.8
10amyloidosis10.6
11sick sinus syndrome 110.5
12sick sinus syndrome 310.4
13thyrotoxicosis10.4
14isolated levocardia10.4
15sick sinus syndrome 2, autosomal dominant10.4
16sick sinus syndrome 1, autosomal recessive10.4
17sinus node disease and myopia10.4
18dextrocardia10.3
19parkinson's disease10.3
20artery disease10.3
21myotonic dystrophy10.3
22pericarditis10.3
23polymyositis10.3
24thromboembolism10.3
25levocardia10.3
26erdheim-chester disease10.2
27inferior myocardial infarction10.2
28systemic lupus erythematosus10.2
29lupus erythematosus10.2
30catecholaminergic polymorphic ventricular tachycardia10.2
31left ventricular noncompaction10.2
32limbic encephalitis10.2
33arteriovenous fistula10.1
34acromegaly10.1
35conduct disorder10.1
36alzheimer's disease10.1
37situs inversus10.1
38hypertrophic cardiomyopathy10.1
39infertility10.1
40arrhythmogenic right ventricular dysplasia10.1
41ritter's disease10.1
42glossopharyngeal neuralgia10.1
43typhoid fever10.1
44ebstein anomaly10.1
45cataract10.1
46cervicitis10.1
47encephalitis10.1
48esophagitis10.1
49herpes simplex10.1
50hyperthyroidism10.1

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to sick sinus syndrome

Symptoms for Sick Sinus Syndrome

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Drugs & Therapeutics for Sick Sinus Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Sick Sinus Syndrome

Search NIH Clinical Center for Sick Sinus Syndrome

Genetic Tests for Sick Sinus Syndrome

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Anatomical Context for Sick Sinus Syndrome

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33MalaCards
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MalaCards organs/tissues related to Sick Sinus Syndrome:

33
Heart, Testes, Atrioventricular node, Spleen, Brain, B cells

Animal Models for Sick Sinus Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Sick Sinus Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7HCN4, SCN5A, MYH6, NPPA, NPPB, AGT
2MP:00028738.5PODXL, SCN5A, HCN4, HCN1, F2
3MP:00053767.9F2, CYP27B1, HCN4, PODXL, MYH6, NPPA
4MP:00107687.7F2, HCN2, HCN4, SCN5A, PODXL, MYH6
5MP:00036317.2F2, HCN1, HCN2, HCN3, SCN5A, PODXL
6MP:00053855.4AGT, F2, HCN1, HCN2, HCN3, HCN4

Publications for Sick Sinus Syndrome

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Sources:
52PubMed
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Articles related to Sick Sinus Syndrome:

(show top 50)    (show all 485)
idTitleAuthorsYear
1
Isolated cardiac involvement in primary amyloidosis: presenting as sick sinus syndrome and heart failure. (24391340)
2013
2
Left atrial responses to acute right ventricular apical pacing in patients with sick sinus syndrome. (23822568)
2013
3
Sick sinus syndrome in a dog: treatment with dual-chambered pacemaker implantation. (23115373)
2012
4
Sick sinus syndrome associated with topical timolol maleate instillation. (22025865)
2011
5
Not so fast! Sick sinus syndrome is a complex and incompletely understood disease that might prove hard to model in animals. (21791463)
2011
6
Congenital sick sinus syndrome with atrial inexcitability and coronary sinus flutter. (22010118)
2011
7
Sick sinus syndrome with Alzheimer's disease for bilateral hernia repair. (21772702)
2011
8
Prevalence of the Brugada-type electrocardiogram and incidence of Brugada syndrome in patients with sick sinus syndrome. (20019410)
2010
9
Atrial size independently correlates with the development of paroxysmal atrial fibrillation in patients with sick sinus syndrome. (21199611)
2010
10
A patient with sick sinus syndrome, atrial flutter and bidirectional ventricular tachycardia: Coincident or concomitant presentations? (18651526)
2007
11
I was recently diagnosed with sick sinus syndrome. What is this exactly, and is it a serious condition? (17387777)
2007
12
Role of the low amplitude potential in the initial P wave signal-averaged electrocardiogram [corrected] in sick sinus syndrome. (16864929)
2006
13
Isolated noncompaction of left ventricular myocardium with fetal sustained bradycardia due to sick sinus syndrome. (17290580)
2006
14
A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. (15910881)
2005
15
Ebstein anomaly associated with unusual conduction delay and sick sinus syndrome. (15226641)
2004
16
Familial sick sinus syndrome complicated by extensive cardiac conduction disturbance. (15094010)
2004
17
Blood pressure variability in paced patients with sick sinus syndrome. (11918152)
2002
18
Physiologic atrial cardiac pacing for the prevention of chronic atrial fibrillation associated with sick sinus syndrome. (11814087)
2002
19
Regional myocardial blood flow in patients with sick sinus syndrome randomized to long-term single chamber atrial or dual chamber pacing--effect of pacing mode and rate. (10807447)
2000
20
Stroke in paced patients with sick sinus syndrome: influence of left atrial function and size. (10516407)
1999
21
AAI pacing for sick sinus syndrome: first choice on all counts. (9875100)
1998
22
Prospective randomised trial of atrial versus ventricular pacing in sick-sinus syndrome. (7983951)
1994
23
Atrial adaptive rate pacing in sick sinus syndrome: effects on exercise capacity and arrhythmias. (8435244)
1993
24
Update on sick sinus syndrome, a cardiac disorder of aging. (2403955)
1990
25
Sick sinus syndrome as a complication of mediastinal radiation therapy. (2337864)
1990
26
Cardiac electrophysiologic properties of intravenous isradipine in patients with sick sinus syndrome. (2523662)
1989
27
Long-term follow-up of patients with sick sinus syndrome: a comparison of clinical aspects among unpaced, ventricular inhibited paced, and physiologically paced groups. (2462243)
1988
28
Syncope in the elderly. Report of 3 cases with sick sinus syndrome. (3704847)
1986
29
Sick sinus syndrome: adenosine mediated? (2860359)
1985
30
Sick sinus syndrome: the role of hypervagotonia. (6724752)
1984
31
Suspected sick sinus syndrome in an infant treated by pacemaker implantation. (6473126)
1984
32
Pacemaker treatment of sick sinus syndrome in children. (6833672)
1983
33
Comparative evaluation of depressed automaticity in sick sinus syndrome by Holter monitoring and overdrive suppression test. (6682281)
1983
34
Sinoatrial arrest due to lidocaine injection in sick sinus syndrome during amiodarone administration. (7148661)
1982
35
Polymyositis presenting as sick sinus syndrome. (7122376)
1982
36
A clinicopathologic study on sick sinus syndrome with histological approach to the sinoatrial node. (7401276)
1980
37
Effect of verapamil on normal sinoatrial node function and on sick sinus syndrome. (717239)
1978
38
The sick sinus syndrome. A study of 50 cases. (621450)
1978
39
Symptomatic improvement in a patient with sick sinus syndrome after the onset of stable atrial flutter. (95640)
1978
40
Sick sinus syndrome due to cardiac amyloidosis. (657173)
1978
41
A case of supraventricular tachycardia in an infant probably due to sick sinus syndrome. (913311)
1977
42
Treatment of sick sinus syndrome with permanent cardiac pacemaker. (Sick sinus syndrome and artificial pacemaker). (591551)
1977
43
Clinical spectrum of the sick sinus syndrome. (836172)
1977
44
Sick sinus syndrome. (1047966)
1976
45
First-degree sinoatrial heart block: sinoatrial block in the sick-sinus syndrome. (1258728)
1976
46
"Paradoxical" prolongation of sinus nodal recovery time after atropine in the sick sinus syndrome. (1146702)
1975
47
Sick sinus syndrome. Symptomatic cases in children. (1211960)
1975
48
Letter: Sick sinus syndrome. (1174896)
1975
49
Sick sinus syndrome: experience of a cardiac pacemaker clinic. (4415767)
1974
50
Appraisal of sinus nodal recovery time in patients with sick sinus syndrome. (4850629)
1974

Variations for Sick Sinus Syndrome

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Sick Sinus Syndrome:

1
id Gene Name Type Significance SNP ID Assembly Location
1SCN5ANM_000335.4(SCN5A): c.5347G> A (p.Glu1783Lys)single nucleotide variantPathogenicrs137854601GRCh37Chr 3, 38592513: 38592513
2SCN5ANM_000335.4(SCN5A): c.3890C> T (p.Pro1297Leu)single nucleotide variantPathogenicrs28937319GRCh37Chr 3, 38603976: 38603976

Expression for genes affiliated with Sick Sinus Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for genes affiliated with Sick Sinus Syndrome

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 51PharmGKB, 55Reactome, 12EMD Millipore
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Pathways related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SCN5A, MYH6
29.8NPPA, NPPB
39.6HCN4, SCN5A, HCN2
49.4NPPA, AGT, NPPB
5
Show member pathways
8.5HCN1, HCN2, HCN3, HCN4
68.5HCN3, HCN2, HCN1, HCN4
7
Show member pathways
8.5HCN3, HCN4, HCN1, HCN2
8
Show member pathways
8.3HCN3, SCN5A, HCN4, HCN2, HCN1
9
Show member pathways
8.3HCN3, HCN2, HCN1, HCN4, MYH6

Compounds for genes affiliated with Sick Sinus Syndrome

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1p000354510.2NPPA, NPPB
2hncs4510.2NPPA, NPPB
3candoxatril45 1111.2NPPA, NPPB
4alacepril4510.1NPPA, NPPB
5ly 835834510.1AGT, NPPA
6imidapril45 5111.1NPPA, NPPB
7urodilatin4510.1NPPB, NPPA
8hanp4510.1NPPA, NPPB
9bisoprolol45 51 1112.0NPPB, NPPA
10inulin4510.0NPPA, AGT
11trandolapril45 1111.0NPPB, NPPA
12moxonidine459.8NPPA, NPPB
13enalaprilat459.8AGT, NPPB, NPPA
14lisinopril45 51 24 1112.8NPPA, NPPB, AGT
158-bromo cgmp459.8AGT, NPPA, NPPB
16perindopril45 51 1111.8NPPA, AGT, NPPB
17enalapril45 51 1111.8AGT, NPPB, NPPA
18amlodipine45 51 24 1112.8AGT, NPPB, NPPA
19captopril45 61 51 29 1113.8AGT, NPPA, NPPB
20ang ii459.8AGT, NPPB, NPPA
21l-nmma459.8NPPB, NPPA, AGT
22dobutamine45 29 51 1112.8NPPB, NPPA
23phenylephrine45 29 24 1112.8NPPA, NPPB, AGT
24losartan45 51 29 1112.7NPPB, NPPA, AGT
25hydroxyethyl starch459.7NPPA, F2
26digoxin45 61 51 24 1113.7NPPB, NPPA, F2
27haloperidol45 51 29 3 1113.7NPPB, AGT, NPPA
28fosinopril45 1110.7NPPA, NPPB
29aprotinin45 1110.6NPPB, F2, AGT
30guanylate459.6AGT, NPPA, NPPB
31isoproterenol45 1110.5NPPB, MYH6, AGT, NPPA
32benazepril45 51 1111.5NPPA, AGT
33norepinephrine45 24 1111.5AGT, NPPA, MYH6, NPPB
34homocysteine45 2410.5F2, NPPB, AGT
35estradiol45 24 1111.4CYP27B1, NPPB, AGT, MYH6
36forskolin45 51 1111.4NPPB, CYP27B1, NPPA, AGT
37potassium45 24 1111.4AGT, NPPA, HCN2, HCN4, SCN5A
38epinephrine45 24 1111.3NPPA, F2, AGT, NPPB
39arginine459.2AGT, NPPB, NPPA, MYH6, SCN5A
40cyclosporin a45 29 6111.2F2, NPPB, AGT, NPPA
41pge2459.2AGT, CYP27B1, NPPA, NPPB
42oxygen45 2410.0NPPA, MYH6, CYP27B1, AGT, NPPB
43ivabradine299.0HCN4, HCN1, HCN2, HCN3
44zatebradine299.0HCN1, HCN2, HCN3, HCN4
45cilobradine299.0HCN4, HCN3, HCN2, HCN1
46zd7288299.0HCN4, HCN3, HCN1, HCN2
47cs+299.0HCN1, HCN4, HCN3, HCN2
48estrogen458.9F2, CYP27B1, MYH6, NPPB, NPPA
49cyclic amp45 249.3HCN4, NPPA, HCN3, HCN2, HCN1, CYP27B1
50sodium45 248.6AGT, SCN5A, NPPA, HCN1, NPPB, HCN4

GO Terms for genes affiliated with Sick Sinus Syndrome

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16Gene Ontology
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Cellular components related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.0PODXL, HCN4, HCN3, HCN2, HCN1
2plasma membraneGO:0058866.4RGS6, F2, HCN1, HCN2, HCN3, HCN4

Biological processes related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cellular response to cGMPGO:07132110.1HCN2, HCN4
2cGMP biosynthetic processGO:0061829.9NPPB, NPPA
3regulation of heart rateGO:0020279.9HCN4, SCN5A, MYH6
4receptor guanylyl cyclase signaling pathwayGO:0071689.8NPPB, NPPA
5regulation of blood vessel sizeGO:0508809.8NPPA, NPPB
6regulation of blood pressureGO:0082179.7NPPB, NPPA, MYH6
7positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6AGT, F2
8positive regulation of renal sodium excretionGO:0358159.6NPPB, AGT
9positive regulation of reactive oxygen species metabolic processGO:20003799.3AGT, F2
10negative regulation of cell growthGO:0303089.3AGT, NPPB, NPPA, CYP27B1
11cellular response to cAMPGO:0713208.8HCN1, HCN2, HCN3, HCN4
12potassium ion transmembrane transportGO:0718058.8HCN1, HCN2, HCN3, HCN4
13regulation of membrane potentialGO:0423918.8HCN1, HCN2, HCN3, HCN4
14synaptic transmissionGO:0072688.6HCN1, HCN2, HCN3, HCN4
15sodium ion transmembrane transportGO:0357258.6SCN5A, HCN4, HCN3, HCN2, HCN1

Molecular functions related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3F2, NPPA, NPPB
2intracellular cAMP activated cation channel activityGO:0052229.3HCN1, HCN4, HCN2
3hormone activityGO:0051799.1NPPB, NPPA, AGT
4cAMP bindingGO:0305528.6HCN2, HCN3, HCN4, HCN1
5voltage-gated potassium channel activityGO:0052498.5HCN3, HCN1, HCN2, HCN4
6voltage-gated sodium channel activityGO:0052488.4HCN3, HCN1, HCN2, HCN4, SCN5A

Products for genes affiliated with Sick Sinus Syndrome

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Sources for Sick Sinus Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet