SND
MCID: SCK002
MIFTS: 52

Sick Sinus Syndrome (SND) malady

Cardiovascular diseases category

Summaries for Sick Sinus Syndrome

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21Genetics Home Reference, 63Wikipedia, 32MalaCards
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Genetics Home Reference:21 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards: Sick Sinus Syndrome, also known as sinus node dysfunction, is related to atrioventricular block and brugada syndrome. An important gene associated with Sick Sinus Syndrome is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Cardiomyocyte Differentiation through BMP Receptors. The compounds isoproterenol and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related mouse phenotypes are muscle and cardiovascular system.

Wikipedia:63 Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of... more...

Aliases & Classifications for Sick Sinus Syndrome

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8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

sick sinus syndrome 8 21 10 44 60
sinus node dysfunction 21 60
sinus node disease 21
snd 21
sss 21


External Ids:

Disease Ontology8 DOID:13884
NCIt39 C62244
MeSH34 D012804
ICD1025 I49.5

Related Diseases for Sick Sinus Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Sick Sinus Syndrome 2 family:

sick sinus syndrome Sick Sinus Syndrome 1
Sick Sinus Syndrome 3

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1atrioventricular block30.9SCN5A, NPPB
2brugada syndrome30.7SCN5A, HCN4
3sick sinus syndrome 230.6HCN4
4myocardial infarction30.3NPPB, NPPA, AGT
5hypertrophic cardiomyopathy30.1MYH6
6atrial heart septal defect30.1NPPB, MYH6
7stroke, ischemic30.1NPPA, F2
8arrhythmogenic right ventricular dysplasia30.1SCN5A
9acute myocardial infarction30.1NPPB, AGT, NPPA
10coronary artery disease30.1AGT, NPPB, NPPA, SCN5A
11diabetes mellitus30.1NPPA, NPPB, CYP27B1, AGT
12amyloidosis10.5
13adult syndrome10.5
14sick sinus syndrome 110.5
15sick sinus syndrome 310.4
16sinus node disease and myopia10.4
17thyrotoxicosis10.3
18image syndrome10.3
19sick sinus syndrome 2, autosomal dominant10.3
20sick sinus syndrome 1, autosomal recessive10.3
21parkinson's disease10.3
22heart lymphoma10.3
23dextrocardia10.3
24myotonic dystrophy10.3
25pericarditis10.3
26erdheim-chester disease10.1
27systemic lupus erythematosus10.1
28lupus erythematosus10.1
29catecholaminergic polymorphic ventricular tachycardia10.1
30arteriovenous fistula10.1
31ebstein anomaly10.1
32congenital heart block10.1
33non-hodgkin lymphoma10.1
34cerebritis10.1
35ritter's disease10.1
36west syndrome10.1
37hemochromatosis10.1
38conduct disorder10.1
39acromegaly10.1
40alzheimer's disease10.1
41situs inversus10.1
42infertility10.1
43inferior myocardial infarction10.1
44typhoid fever10.1
45glossopharyngeal neuralgia10.1
46down syndrome10.1
47cataract10.1
48cervicitis10.1
49encephalitis10.1
50epilepsy syndrome10.1

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to sick sinus syndrome

Clinical Features for Sick Sinus Syndrome

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Drugs & Therapeutics for Sick Sinus Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Sick Sinus Syndrome

Search NIH Clinical Center for Sick Sinus Syndrome

Search CenterWatch for Sick Sinus Syndrome

Genetic Tests for Sick Sinus Syndrome

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Anatomical Context for Sick Sinus Syndrome

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32MalaCards
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MalaCards organs/tissues related to Sick Sinus Syndrome:

32
Heart, Testes, Atrioventricular node, Brain, Spleen, B cells, Endothelial

Animal Models for Sick Sinus Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sick Sinus Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7NPPA, SCN5A, AGT, MYH6, HCN4, NPPB
2MP:00053855.6RGS6, NPPB, NPPA, SCN5A, AGT, PODXL

Publications for Sick Sinus Syndrome

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50PubMed
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Articles related to Sick Sinus Syndrome:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Autosomal recessive paediatric sick sinus syndrome associated with novel compound mutations in SCN5A. (23200271)
2013
2
Atrial pacing in sick sinus syndrome: still plausible? (24140238)
2013
3
Sick sinus syndrome and orthostatic hypotension in Parkinson's disease. (22426666)
2012
4
Polymorphisms of 2B-adrenergic receptor and endothelial NO-Synthase genes in genesis of the hereditary sick sinus node syndrome]. (21878072)
2011
5
Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. (20448214)
2010
6
DDDR pacing results in left ventricular asynchrony with preservation of ejection fraction and NT-proBNP: a prospective study in sick sinus syndrome and normal ventricular function. (19342110)
2010
7
A case of chloroquine-induced cardiomyopathy that presented as sick sinus syndrome. (21217940)
2010
8
Right ventricular apical pacing acutely impairs left ventricular function and induces mechanical dyssynchrony in patients with sick sinus syndrome: a real-time three-dimensional echocardiographic study. (17904807)
2008
9
Efficacy of consistent atrial pacing algorithm for suppression of atrial arrhythmias in patients with sick sinus syndrome and atrial fibrillation. (18612185)
2008
10
An isolated case of left ventricular non-compaction with sick sinus syndrome. (18400647)
2008
11
Pacemaker diagnostics to determine treatment and outcome in sick sinus syndrome with paroxysmal atrial fibrillation. (15305963)
2004
12
Sinus slowing caused by adenosine-5'-triphosphate in patients with and without sick sinus syndrome under various autonomic states. (15484159)
2004
13
Predictors of stroke in patients paced for sick sinus syndrome. (15120821)
2004
14
Clinical significance of preserving spontaneous QRS wave in the therapy of DDD pacing for sick sinus syndrome. (15461710)
2004
15
Evaluation of pacemaker telemetry as a diagnostic feature for detecting atrial tachyarrhythmias in patients with sick sinus syndrome. (15519261)
2004
16
Blood pressure variability in paced patients with sick sinus syndrome. (11918152)
2002
17
Physiologic atrial cardiac pacing for the prevention of chronic atrial fibrillation associated with sick sinus syndrome. (11814087)
2002
18
Sudden death under successful medical management of sick sinus syndrome after cardiac pacing discontinuation. (12428388)
2002
19
AV block and changes in pacing mode during long-term follow-up of 399 consecutive patients with sick sinus syndrome treated with an AAI/AAIR pacemaker. (11310306)
2001
20
Left atrial systolic function assessed by left atrial ejection force in patients with sick sinus syndrome and paroxysmal atrial fibrillation. (11232989)
2000
21
Arterial thromboembolism in patients with sick sinus syndrome: prediction from pacing mode, atrial fibrillation, and echocardiographic findings. (10092569)
1999
22
Pacing in sick sinus syndrome--need for a prospective, randomized trial comparing atrial with dual chamber pacing. (9633057)
1998
23
Advances in pacing for the patient with sick sinus syndrome. (9132078)
1997
24
Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial. (9236443)
1997
25
Bradycardia associated with fluoxetine in an elderly patient with sick sinus syndrome. (8140029)
1994
26
A case report of isolated levocardia without intracardiac anomalies associated with sick sinus syndrome. (8464143)
1993
27
Sick sinus syndrome as a complication of mediastinal radiation therapy. (2337864)
1990
28
Relation of prognosis in sick sinus syndrome to age, conduction defects and modes of permanent cardiac pacing. (2316455)
1990
29
Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome. (3376162)
1988
30
Dihydralazine in sick sinus syndrome. (3447972)
1987
31
Oral verapamil and calcium infusion in patients with sick sinus syndrome. (3438222)
1987
32
Atrial pacing in the management of sick sinus syndrome: long-term observation for conduction disturbances and supraventricular tachyarrhythmias. (3699046)
1986
33
Long-term management of bradyarrhythmias following open heart surgery: surgical A-V block and sick sinus syndrome after surgery for secundum atrial septal defects treated with permanent cardiac pacing. (3099026)
1986
34
AV conduction in sick sinus syndrome. (4003258)
1985
35
Electrocardiogram of the month. Sick sinus syndrome. (6591924)
1984
36
The role of autonomic chronotropic influences in patients with the sick sinus syndrome. (6586991)
1984
37
Lithium-induced dysrhythmias as a marker for sick sinus syndrome. (6833969)
1983
38
Atriopathic arrhythmias--sick sinus syndrome. (6658984)
1983
39
Appearance of sick sinus syndrome after years of micturition syncope. A case report. (7116838)
1982
40
Direct Wenckebach periods in the left bundle branch during bradycardia-dependent left bundle branch block in a patient with sick sinus syndrome. (7411000)
1980
41
Sick sinus syndrome. (7441037)
1980
42
Symptomatic sick sinus syndrome due to guanethidine. Case report. (541046)
1979
43
Usefulness of carotid sinus pressure in detecting the sick sinus syndrome. (690552)
1978
44
A case of supraventricular tachycardia in an infant probably due to sick sinus syndrome. (913311)
1977
45
Treatment of sick sinus syndrome with permanent cardiac pacemaker. (Sick sinus syndrome and artificial pacemaker). (591551)
1977
46
The etiology of sino-atrial disorder (Sick Sinus Syndrome). (961593)
1976
47
A clinicopathological study on the sick sinus syndrome. (1011366)
1976
48
Demonstration of diffuse conduction disturbance in sick sinus syndrome utilizing simultaneous His bundle electrogram and timed vectorcardiogram. (971614)
1976
49
Sinus node recovery time and abnormal postpacing phase in the aged patients with sick sinus syndrome. (948110)
1976
50
Proceedings: The sick sinus syndrome. (4429370)
1974

Genetic Variations for Sick Sinus Syndrome

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Expression for genes affiliated with Sick Sinus Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for genes affiliated with Sick Sinus Syndrome

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 49PharmGKB, 12EMD Millipore
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Compounds for genes affiliated with Sick Sinus Syndrome

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1isoproterenol44 1111.6MYH6
2norepinephrine44 11 2412.5MYH6
3hncs4410.2NPPA, NPPB
4p000354410.2NPPA, NPPB
5ly 835834410.2AGT, NPPA
6alacepril4410.2NPPA, NPPB
7candoxatril44 1111.2NPPA, NPPB
8imidapril4410.2NPPA, NPPB
9benazepril44 1111.2AGT, NPPA
10urodilatin4410.2NPPA, NPPB
11inulin4410.2NPPA, AGT
12trandolapril44 1111.1NPPB, NPPA
13bisoprolol44 49 1112.1NPPB, NPPA
14hanp4410.1NPPB, NPPA
15dobutamine44 28 1112.1NPPB, NPPA
16moxonidine4410.1NPPB, NPPA
17fosinopril44 1111.1NPPB, NPPA
18hydroxyethyl starch4410.0NPPA, F2
19enalaprilat449.9NPPB, NPPA, AGT
20lisinopril44 11 2411.9AGT, NPPA, NPPB
218-bromo cgmp449.9NPPB, NPPA, AGT
22perindopril44 49 1111.9AGT, NPPA, NPPB
23enalapril44 49 1111.9NPPB, NPPA, AGT
24amlodipine44 49 11 2412.9AGT, NPPA, NPPB
25ang ii449.9AGT, NPPA, NPPB
26l-nmma449.9NPPB, NPPA, AGT
27phenylephrine44 28 11 2412.8NPPB, NPPA, AGT
28losartan44 49 28 1112.8AGT, NPPA, NPPB
29nppb44 59 2811.8NPPB, NPPA
30digoxin44 49 59 11 2413.8NPPB, NPPA, F2
31haloperidol44 28 2 49 1113.8AGT, NPPA, NPPB
32metoprolol44 28 49 11 2413.7NPPB, NPPA
33aprotinin44 1110.7NPPB, AGT, F2
34guanylate449.6NPPB, NPPA, AGT
35forskolin44 49 1111.6AGT, NPPA, NPPB
36homocysteine44 2410.5F2, AGT, NPPB
37mibg449.5NPPA, NPPB
38potassium44 11 2411.5NPPA, SCN5A, AGT, HCN2, HCN4
39epinephrine44 11 2411.4NPPB, NPPA, AGT, F2
40estradiol44 11 2411.4CYP27B1, MYH6, AGT, NPPB
41cilobradine289.3HCN3, HCN2, HCN4, HCN1
42zd7288289.3HCN2, HCN4, HCN1, HCN3
43ivabradine289.3HCN2, HCN4, HCN1, HCN3
44zatebradine289.3HCN2, HCN4, HCN1, HCN3
45cs+289.3HCN2, HCN4, HCN1, HCN3
46arginine449.2MYH6, AGT, SCN5A, NPPA, NPPB
47pge2449.2CYP27B1, AGT, NPPA, NPPB
48cyclosporin a44 28 5911.1NPPB, NPPA, AGT, F2
49cyclic amp44 249.7NPPA, HCN2, HCN4, HCN1, HCN3, CYP27B1
50sodium44 249.0NPPB, NPPA, SCN5A, AGT, HCN2, HCN4

GO Terms for genes affiliated with Sick Sinus Syndrome

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16Gene Ontology
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Cellular components related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.1RGS6, F2, HCN3, HCN1, HCN4, HCN2

Biological processes related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0NPPA, NPPB
2receptor guanylyl cyclase signaling pathwayGO:00716810.0NPPA, NPPB
3regulation of heart contractionGO:00801610.0HCN4, MYH6
4cation transportGO:0068129.9HCN4, HCN2
5regulation of blood vessel sizeGO:0508809.9NPPA, NPPB
6positive regulation of renal sodium excretionGO:0358159.9AGT, NPPB
7muscle contractionGO:0069369.9MYH6, HCN2, HCN4
8regulation of heart rateGO:0020279.9SCN5A, MYH6
9regulation of blood pressureGO:0082179.8MYH6, NPPA, NPPB
10positive regulation of reactive oxygen species metabolic processGO:20003799.4F2, AGT
11negative regulation of cell growthGO:0303089.4NPPB, NPPA, AGT, CYP27B1
12potassium ion transmembrane transportGO:0718059.1HCN3, HCN1, HCN4, HCN2
13regulation of membrane potentialGO:0423919.1HCN2, HCN4, HCN1, HCN3
14synaptic transmissionGO:0072688.9HCN2, HCN4, HCN1, HCN3

Molecular functions related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cation channel activityGO:0052619.9HCN4, HCN2
2hormone activityGO:0051799.2AGT, NPPA, NPPB
3sodium channel activityGO:0052728.9HCN3, HCN1, HCN4, HCN2
4cAMP bindingGO:0305528.9HCN2, HCN4, HCN1, HCN3
5voltage-gated potassium channel activityGO:0052498.8HCN2, HCN4, HCN1, HCN3

Products for genes affiliated with Sick Sinus Syndrome

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Sources for Sick Sinus Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet