SND
MCID: SCK002
MIFTS: 50

Sick Sinus Syndrome (SND) malady

Categories: Cardiovascular diseases, Muscle diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Sick Sinus Syndrome

Aliases & Descriptions for Sick Sinus Syndrome:

Name: Sick Sinus Syndrome 12 25 29 52 42 14 69
Sinus Node Dysfunction 25 29 69
Sinus Node Infection 12
Sinus Node Disease 25
Sss 25
Snd 25

Classifications:



External Ids:

Disease Ontology 12 DOID:13884
ICD10 33 I49.5
MeSH 42 D012804
NCIt 47 C62244
UMLS 69 C0037052

Summaries for Sick Sinus Syndrome

Genetics Home Reference : 25 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards based summary : Sick Sinus Syndrome, also known as sinus node dysfunction, is related to sick sinus syndrome 1 and sick sinus syndrome 2. An important gene associated with Sick Sinus Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Antiarrhythmic Pathway, Pharmacodynamics and Cardiac Progenitor Differentiation. The drugs Amiodarone and Propafenone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Wikipedia : 71 Sick sinus syndrome (SSS), also called sinus dysfunction, or sinoatrial node disease (\"SND\"), is a... more...

Related Diseases for Sick Sinus Syndrome

Diseases in the Sick Sinus Syndrome family:

Sick Sinus Syndrome 1 Sick Sinus Syndrome 3
Sick Sinus Syndrome 2 Familial Sick Sinus Syndrome

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 sick sinus syndrome 1 12.4
2 sick sinus syndrome 2 12.4
3 sick sinus syndrome 3 12.4
4 familial sick sinus syndrome 12.2
5 sinus node disease and myopia 12.0
6 isolated levocardia 11.3
7 chronic atrial and intestinal dysrhythmia 11.2
8 cardiac arrhythmia, ankyrin-b-related 10.9
9 atrial fibrillation 10.4
10 syncope 10.3
11 atrioventricular block 10.2
12 lipodystrophy, familial partial, type 5 10.2 HCN4 SCN5A
13 uterine fibroid 10.1 HCN4 SCN5A
14 third-degree atrioventricular block 10.1 HCN4 SCN5A
15 amyloidosis 10.1
16 lymphoma 10.0
17 synostosis 10.0 F2 XK
18 optic nerve disease 10.0 F2 MYH6
19 brugada syndrome 10.0
20 cardiomyopathy 10.0
21 antley-bixler syndrome 9.9 HCN4 RANGRF SCN5A
22 hemorrhagic shock and encephalopathy syndrome 9.9 SCN5A XK
23 micturation-induced seizures 9.9 AGT HCN4 MYH6 SCN5A
24 heart disease 9.9
25 adams-oliver syndrome 9.9 AGT F2 HCN4 SCN5A
26 artery disease 9.8
27 polymyositis 9.8
28 pericarditis 9.8
29 dextrocardia 9.8
30 myocardial infarction 9.8
31 myotonic dystrophy 9.8
32 levocardia 9.8
33 familial periodic paralysis 9.8 F2 HCN4 SCN5A SHOX2
34 brachyolmia type 3 9.7 MYH6 SHOX2 TBX3
35 adenocarcinoma 9.7
36 cor triatriatum 9.7
37 hodgkin lymphoma 9.7
38 lipomatosis 9.7
39 dextrocardia with situs inversus 9.7
40 crest syndrome 9.7
41 cerebritis 9.7
42 herpes simplex encephalitis 9.7
43 intestinal pseudo-obstruction 9.7
44 cardiac arrest 9.7
45 infertility 9.7
46 mitral valve disease 9.7
47 hemochromatosis 9.7
48 esophagitis 9.7
49 situs inversus 9.7
50 transposition of the great arteries 9.7

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to Sick Sinus Syndrome

Symptoms & Phenotypes for Sick Sinus Syndrome

GenomeRNAi Phenotypes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.7 SHOX2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.7 SCN5A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.7 F2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.7 SHOX2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.7 F2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.7 SCN5A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.7 F2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.7 SCN5A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.7 F2 SCN5A SHOX2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.7 SHOX2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.7 F2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.7 SHOX2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.7 F2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.7 SCN5A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.7 SCN5A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.7 SHOX2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 SCN5A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 SCN5A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.7 F2 SCN5A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.7 SHOX2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.7 SCN5A

MGI Mouse Phenotypes related to Sick Sinus Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 AGT F2 HCN4 MYH6 SCN5A SHOX2
2 mortality/aging MP:0010768 9.56 AGT F2 HCN4 MYH6 SCN5A SGO1
3 muscle MP:0005369 9.1 AGT HCN4 MYH6 SCN5A TBX3 XK

Drugs & Therapeutics for Sick Sinus Syndrome

Drugs for Sick Sinus Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
2
Propafenone Approved Phase 4 54063-53-5 4932
3
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
4
Ethanol Approved Phase 4 64-17-5 702
5 Adrenergic Agents Phase 4,Phase 3
6 Adrenergic Antagonists Phase 4,Phase 3
7 Adrenergic beta-Antagonists Phase 4,Phase 3
8 Anti-Arrhythmia Agents Phase 4,Phase 3
9 Autonomic Agents Phase 4,Phase 3
10 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
12 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
13 Cytochrome P-450 CYP3A Inhibitors Phase 4
14 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
15 Diuretics, Potassium Sparing Phase 4
16 Neurotransmitter Agents Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Potassium Channel Blockers Phase 4
19 Sodium Channel Blockers Phase 4
20 Sympatholytics Phase 4,Phase 3
21 Vasodilator Agents Phase 4
22
Losartan Approved Phase 3 114798-26-4 3961
23
Atenolol Approved Phase 3 29122-68-7 2249
24
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 439542 10909430
25
Cephalexin Approved, Vet_approved Phase 3 15686-71-2 27447
26
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
27
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
28
Ofloxacin Approved Phase 3 82419-36-1 4583
29
Angiotensin II Phase 3 68521-88-0, 11128-99-7 65143 172198
30 Angiotensin II Type 1 Receptor Blockers Phase 3
31 Angiotensin Receptor Antagonists Phase 3
32 Angiotensinogen Phase 3
33 Antihypertensive Agents Phase 3
34 Adrenergic beta-1 Receptor Antagonists Phase 3
35 Antibodies Phase 2, Phase 3
36 gamma-Globulins Phase 2, Phase 3
37 Immunoglobulins Phase 2, Phase 3
38 Immunoglobulins, Intravenous Phase 2, Phase 3
39 Pharmaceutical Solutions Phase 2, Phase 3
40 Rho(D) Immune Globulin Phase 2, Phase 3
41 Anti-Bacterial Agents Phase 3
42 Antibiotics, Antitubercular Phase 3
43 Anti-Infective Agents Phase 3
44 Anti-Infective Agents, Local Phase 3
45 Antitubercular Agents Phase 3
46 Clindamycin palmitate Phase 3
47 Clindamycin phosphate Phase 3
48 Polymyxin B Phase 3
49 Polymyxins Phase 3
50 Renal Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 64)
id Name Status NCT ID Phase
1 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
2 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
3 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation Unknown status NCT00224341 Phase 4
4 Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation Unknown status NCT02145546 Phase 4
5 Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation Completed NCT00161538 Phase 4
6 Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing Completed NCT00286858 Phase 4
7 Austria Study - Analysis of Difference Between Active and Passive Fixation Leads Completed NCT00180557 Phase 4
8 Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease Completed NCT01170611 Phase 4
9 Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study) Completed NCT00664807 Phase 4
10 DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed NCT00478933 Phase 4
11 Falls and Cardiovascular Events in Pacemaker Patients Completed NCT01037426 Phase 4
12 PANORAMA Observational Study Completed NCT00382525 Phase 4
13 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
14 Syncope: Pacing or Recording in the Later Years Active, not recruiting NCT01423994 Phase 4
15 Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock Enrolling by invitation NCT02668432 Phase 4
16 Virtual Clinic Pacemaker Follow-up Terminated NCT00475124 Phase 4
17 Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation Completed NCT02317068 Phase 3
18 Mode Selection Trial in Sinus Node Dysfunction (MOST) Completed NCT00000561 Phase 3
19 Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome--Pediatric Heart Network Completed NCT00429364 Phase 3
20 Phase 2/3 Study of IGSC, 20% in PIDD Completed NCT01218438 Phase 2, Phase 3
21 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3
22 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
23 Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum Completed NCT01609738 Phase 1, Phase 2
24 Second Study on Cardio-neuromodulation in Humans Recruiting NCT02954666 Phase 2
25 Gulf War Illness Nasal Irrigation Study Active, not recruiting NCT01700725 Phase 2
26 RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome Unknown status NCT01477138
27 The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome Unknown status NCT01310920
28 The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome Unknown status NCT00647257
29 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
30 Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI) Unknown status NCT00785564
31 Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study Unknown status NCT02314897
32 Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan Unknown status NCT00314223
33 Right Ventricular Lead Placement in a Pacemaker Population: Evaluation of Apical and Alternative Position Unknown status NCT01647490
34 A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction Unknown status NCT02027909
35 Minimizing Ventricular Pacing Unknown status NCT01611389
36 Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study Completed NCT01528657
37 Right Ventricle (RV) Markers of Future Pacing Induced Ventricular Dysfunction - Pilot Completed NCT02198781
38 The Atrial High Rate Episodes in Pacemaker Patients Completed NCT00627328
39 Prospective Registry of Pacemaker Patients Concerning Percentage of Right Ventricular Pacing, LVEF and NYHA Class Completed NCT00292539
40 SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction Completed NCT00284830
41 Natural Evolution of AV Conduction Disorders in Patients Implanted With Cardiac Pacemakers Completed NCT00531037
42 To Pace or Not to Pace in Sinus Node Disease Completed NCT02485093
43 Right Ventricular Outflow Tract Study Completed NCT01294839
44 Evaluation of Pacemaker Algorithms to Avoid Unnecessary Right Ventricular Pacing Completed NCT01803217
45 Ingenio Device Algorithm Study Completed NCT01441583
46 IES-ACap: Influence of Atrial Pulse Width in the Behaviour of ACap™ Confirm Algorithm. Completed NCT00832260
47 Real Life Automatic Atrial Capture Device Control Completed NCT02400983
48 Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome. Recruiting NCT02034526
49 Left Ventricular Pacing to Avoid Cardiac Enlargement Study Recruiting NCT01302717
50 Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady) Recruiting NCT01643707

Search NIH Clinical Center for Sick Sinus Syndrome

Cochrane evidence based reviews: sick sinus syndrome

Genetic Tests for Sick Sinus Syndrome

Genetic tests related to Sick Sinus Syndrome:

id Genetic test Affiliating Genes
1 Sick Sinus Syndrome 29
2 Sinus Node Disease 29

Anatomical Context for Sick Sinus Syndrome

MalaCards organs/tissues related to Sick Sinus Syndrome:

39
Heart, Testes, Atrioventricular Node, Lung, B Cells, Brain, Spleen

Publications for Sick Sinus Syndrome

Articles related to Sick Sinus Syndrome:

(show top 50) (show all 530)
id Title Authors Year
1
Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls. ( 28525326 )
2017
2
Persistent Sick Sinus Syndrome in Scrub Typhus. ( 28500798 )
2017
3
SEVERE AMIODARONE-INDUCED BRADICARDIA CONCEALES SICK SINUS SYNDROME: CASE REPORT. ( 27125081 )
2016
4
Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002-2014). ( 27286907 )
2016
5
Transforming Growth Factor-I^1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein Level. ( 27380173 )
2016
6
Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome. ( 26798387 )
2016
7
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block. ( 26831068 )
2016
8
Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. ( 27182706 )
2016
9
Single lead atrial vs. dual chamber pacing in sick sinus syndrome: extended register-based follow-up in the DANPACE trial. ( 28039212 )
2016
10
Autosomal recessive atrial disease presenting with sick sinus syndrome (SSS), right atrial fibrosis and biatrial dilatation: Clinical impact of genetic diagnosis. ( 26828384 )
2016
11
Predictors of sick sinus syndrome in patients after successful radiofrequency catheter ablation of atrial flutter. ( 25510744 )
2015
12
Beneficial effects of losartan for prevention of paroxysmal atrial fibrillation in patients with sick sinus syndrome: analysis with memory function of pacemaker. ( 25787020 )
2015
13
Beware of Venous Anomalies in Young Patients with Sick Sinus Syndrome: A Report of Two Cases of Sick Sinus Syndrome with Systemic Venous Anomalies. ( 27326354 )
2015
14
Development of Atrioventricular Block and Diagnostic Value of Stored Electrograms in Patients With Sick Sinus Syndrome and Implanted Pacemaker. ( 25753690 )
2015
15
Anaplastic lymphoma kinase-positive lung adenocarcinoma patient with development of sick sinus syndrome while on targeted treatment with crizotinib. ( 25922742 )
2015
16
Combined Algorithm Using a Poor Increase in Inferior P-Wave Amplitude During Sympathetic Stimulation and Sinus Node Recovery Time for the Diagnosis of Sick Sinus Syndrome. ( 26289967 )
2015
17
Sodium Hydroxide Pinpoint Pressing Permeation Method for the Animal Modeling of Sick Sinus Syndrome. ( 26118592 )
2015
18
Sick Sinus Syndrome. ( 26485000 )
2015
19
Stored intracardiac electrograms reveal patients with sick sinus syndrome frequently develop atrioventricular block. ( 25947003 )
2015
20
Novel Mutation in the I+-Myosin Heavy Chain Gene Is Associated With Sick Sinus Syndrome. ( 25717017 )
2015
21
ECG of the Month. Third-degree AV block with sick sinus syndrome. ( 25835165 )
2015
22
Effective Management of Atrioventricular Interval for Paroxysmal Atrial Fibrillation That Developed After DDDR Pacemaker Implantation in a Sick Sinus Syndrome Patient. ( 26370366 )
2015
23
Elevated plasma norepinephrine level and sick sinus syndrome in patients with lone atrial fibrillation. ( 25968056 )
2015
24
Red blood cell distribution width and atrial fibrillation in patients with sick sinus syndrome. ( 26321105 )
2015
25
Dual-chamber pacemakers for treating symptomatic bradycardia due to sick sinus syndrome without atrioventricular block: a systematic review and economic evaluation. ( 26293406 )
2015
26
Sick sinus syndrome and atrial fibrillation in older persons - A view from the sinoatrial nodal myocyte. ( 25668431 )
2015
27
Role of temporary pacing at the right ventricular outflow tract in anesthetic management of a patient with asymptomatic sick sinus syndrome. ( 26712989 )
2015
28
Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics. ( 24762805 )
2014
29
Association of sick sinus syndrome with incident cardiovascular disease and mortality: the atherosclerosis risk in communities study and cardiovascular health study. ( 25285853 )
2014
30
Sick sinus syndrome: synopsis. ( 25104520 )
2014
31
Genetic analysis in a family affected by sick sinus syndrome may reduce the sudden death risk in a young aspiring competitive athlete. ( 24295898 )
2014
32
Right versus left atrial pacing in patients with sick sinus syndrome and paroxysmal atrial fibrillation (Riverleft study): study protocol for randomized controlled trial. ( 25403703 )
2014
33
The effectiveness of the atrial or atrio-ventricular stimulation for sick sinus syndrome in a long term observation. ( 25001847 )
2014
34
Syncope in paced patients with sick sinus syndrome from the DANPACE trial: incidence, predictors and prognostic implication. ( 24711481 )
2014
35
Isoprenaline: a potential contributor in sick sinus syndrome--insights from a mathematical model of the rabbit sinoatrial node. ( 24578642 )
2014
36
Donepezil-associated sick sinus syndrome. ( 24515686 )
2014
37
Sick sinus syndrome associated with hypopituitarism: a case report and literature review. ( 25332716 )
2014
38
Health economic evaluation of single-lead atrial pacing vs. dual-chamber pacing in sick sinus syndrome. ( 24451290 )
2014
39
A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation. ( 24582607 )
2014
40
Familial sick sinus syndrome. ( 24172807 )
2013
41
Autosomal recessive paediatric sick sinus syndrome associated with novel compound mutations in SCN5A. ( 23200271 )
2013
42
CHADS2 and CHA2DS2-VASc score to assess risk of stroke and death in patients paced for sick sinus syndrome. ( 23539553 )
2013
43
Sick sinus syndrome: a review. ( 23939447 )
2013
44
Sick sinus syndrome: a family study. ( 24020943 )
2013
45
Sick Sinus Syndrome in HCN1-Deficient Mice. ( 24218458 )
2013
46
Efficacy of catheter ablation for atrial fibrillation in patients with a permanent pacemaker for sick sinus syndrome. ( 24126390 )
2013
47
Symptomatic sick sinus syndrome requiring permanent pacemaker implantation in a patient uwith mirror image dextrocardia with situs inversus and infertility. ( 24000510 )
2013
48
MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome. ( 23420830 )
2013
49
Left atrial responses to acute right ventricular apical pacing in patients with sick sinus syndrome. ( 23822568 )
2013
50
A novel SCN5A mutation demonstrating a variety of clinical phenotypes in familial sick sinus syndrome. ( 23955615 )
2013

Variations for Sick Sinus Syndrome

ClinVar genetic disease variations for Sick Sinus Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.5350G> A (p.Glu1784Lys) single nucleotide variant Pathogenic rs137854601 GRCh37 Chromosome 3, 38592513: 38592513
2 SCN5A NM_000335.4(SCN5A): c.3890C> T (p.Pro1297Leu) single nucleotide variant Pathogenic rs28937319 GRCh37 Chromosome 3, 38603976: 38603976

Expression for Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for Sick Sinus Syndrome

Pathways related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.7 HCN4 SCN5A
2 10.35 MYH6 SCN5A

GO Terms for Sick Sinus Syndrome

Cellular components related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.96 RANGRF SCN5A
2 intercalated disc GO:0014704 8.62 RANGRF SCN5A

Biological processes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.52 AGT F2
2 regulation of postsynaptic membrane potential GO:0060078 9.51 HCN4 SCN5A
3 cardiac muscle contraction GO:0060048 9.49 MYH6 SCN5A
4 regulation of heart rate by cardiac conduction GO:0086091 9.48 HCN4 SCN5A
5 positive regulation of reactive oxygen species metabolic process GO:2000379 9.46 AGT F2
6 embryonic forelimb morphogenesis GO:0035115 9.43 SHOX2 TBX3
7 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.4 HCN4 SCN5A
8 regulation of membrane depolarization GO:0003254 9.37 HCN4 RANGRF
9 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 9.32 HCN4 RANGRF
10 regulation of sodium ion transmembrane transport GO:1902305 9.26 RANGRF SCN5A
11 SA node cell action potential GO:0086015 9.16 HCN4 SCN5A
12 regulation of heart rate GO:0002027 9.02 AGT HCN4 MYH6 RANGRF SCN5A
13 membrane depolarization during SA node cell action potential GO:0086046 8.96 HCN4 SCN5A

Molecular functions related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium channel regulator activity GO:0017080 9.16 RANGRF SCN5A
2 sodium channel activity GO:0005272 8.96 HCN4 SCN5A
3 voltage-gated sodium channel activity GO:0005248 8.62 HCN4 SCN5A

Sources for Sick Sinus Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
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55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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