SND
MCID: SCK002
MIFTS: 52

Sick Sinus Syndrome (SND) malady

Cardiovascular diseases category

Summaries for Sick Sinus Syndrome

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21Genetics Home Reference, 63Wikipedia, 32MalaCards
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Genetics Home Reference:21 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards: Sick Sinus Syndrome, also known as sinus node dysfunction, is related to atrioventricular block and brugada syndrome. An important gene associated with Sick Sinus Syndrome is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Cardiomyocyte Differentiation through BMP Receptors. The compounds isoproterenol and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related mouse phenotypes are muscle and cardiovascular system.

Wikipedia:63 Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of... more...

Aliases & Classifications for Sick Sinus Syndrome

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8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

sick sinus syndrome 8 21 10 44 60
sinus node dysfunction 21 60
sinus node disease 21
snd 21
sss 21


External Ids:

Disease Ontology8 DOID:13884
NCIt39 C62244
MeSH34 D012804
ICD1025 I49.5

Related Diseases for Sick Sinus Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Sick Sinus Syndrome 2 family:

sick sinus syndrome Sick Sinus Syndrome 1
Sick Sinus Syndrome 3

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1atrioventricular block30.9SCN5A, NPPB
2brugada syndrome30.7SCN5A, HCN4
3sick sinus syndrome 230.6HCN4
4myocardial infarction30.3NPPB, NPPA, AGT
5hypertrophic cardiomyopathy30.1MYH6
6atrial heart septal defect30.1NPPB, MYH6
7stroke, ischemic30.1NPPA, F2
8arrhythmogenic right ventricular dysplasia30.1SCN5A
9acute myocardial infarction30.1NPPB, AGT, NPPA
10coronary artery disease30.1AGT, NPPB, NPPA, SCN5A
11diabetes mellitus30.1NPPA, NPPB, CYP27B1, AGT
12amyloidosis10.5
13adult syndrome10.5
14sick sinus syndrome 110.5
15sick sinus syndrome 310.4
16sinus node disease and myopia10.4
17thyrotoxicosis10.3
18image syndrome10.3
19sick sinus syndrome 2, autosomal dominant10.3
20sick sinus syndrome 1, autosomal recessive10.3
21parkinson's disease10.3
22heart lymphoma10.3
23dextrocardia10.3
24myotonic dystrophy10.3
25pericarditis10.3
26erdheim-chester disease10.1
27systemic lupus erythematosus10.1
28lupus erythematosus10.1
29catecholaminergic polymorphic ventricular tachycardia10.1
30arteriovenous fistula10.1
31ebstein anomaly10.1
32congenital heart block10.1
33non-hodgkin lymphoma10.1
34cerebritis10.1
35ritter's disease10.1
36west syndrome10.1
37hemochromatosis10.1
38conduct disorder10.1
39acromegaly10.1
40alzheimer's disease10.1
41situs inversus10.1
42infertility10.1
43inferior myocardial infarction10.1
44typhoid fever10.1
45glossopharyngeal neuralgia10.1
46down syndrome10.1
47cataract10.1
48cervicitis10.1
49encephalitis10.1
50epilepsy syndrome10.1

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to sick sinus syndrome

Clinical Features for Sick Sinus Syndrome

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Drugs & Therapeutics for Sick Sinus Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sick Sinus Syndrome

Drug clinical trials:

Search ClinicalTrials for Sick Sinus Syndrome

Search NIH Clinical Center for Sick Sinus Syndrome

Search CenterWatch for Sick Sinus Syndrome

Genetic Tests for Sick Sinus Syndrome

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Anatomical Context for Sick Sinus Syndrome

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32MalaCards
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MalaCards organs/tissues related to Sick Sinus Syndrome:

32
Heart, Testes, Atrioventricular node, Spleen, Brain, B cells, Endothelial

Animal Models for Sick Sinus Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Sick Sinus Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7NPPA, SCN5A, AGT, MYH6, HCN4, NPPB
2MP:00053855.6RGS6, NPPB, NPPA, SCN5A, AGT, PODXL

Publications for Sick Sinus Syndrome

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50PubMed
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Articles related to Sick Sinus Syndrome:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Genetic analysis in a family affected by sick sinus syndrome may reduce the sudden death risk in a young aspiring competitive athlete. (24295898)
2014
2
Efficacy of catheter ablation for atrial fibrillation in patients with a permanent pacemaker for sick sinus syndrome. (24126390)
2013
3
Symptomatic sick sinus syndrome requiring permanent pacemaker implantation in a patient uwith mirror image dextrocardia with situs inversus and infertility. (24000510)
2013
4
Does atrial pacing lead to atrial fibrillation in patients with sick sinus syndrome? Insights from the DANPACE trial. (24169735)
2013
5
Polymorphism of connexin 40 gene-- a novel genetic marker of the sick sinus node syndrome]. (21649591)
2011
6
Can bradycardia pose as a "red herring" in neurosurgery? Surgical stress exposes an asymptomatic sick sinus syndrome: Diagnostic and management dilemmas. (21572755)
2010
7
Genetics of sick sinus syndrome. (21499520)
2010
8
Atrial fibrillation and quality of life after pacemaker implantation for sick sinus syndrome: data from the Mode Selection Trial (MOST). (19540395)
2009
9
The influence of permanent cardiac pacing on plasma levels of B-type natriuretic peptide in patients with sick sinus syndrome. (18651383)
2008
10
I was recently diagnosed with sick sinus syndrome. What is this exactly, and is it a serious condition? (17387777)
2007
11
Pacing mode selection in patients with sick sinus syndrome. (17349215)
2007
12
Brugada-type ECG association with unexpected sick sinus syndrome. (16492310)
2006
13
A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. (15910881)
2005
14
Visual field defects associated with sick sinus syndrome. (15692778)
2005
15
Manifestation of Brugada syndrome after pacemaker implantation in a patient with sick sinus syndrome. (15574187)
2004
16
Long-term clinical performance of AAI pacing in patients with sick sinus syndrome: a comparison with dual-chamber pacing. (15294270)
2004
17
Right atrial tumor and sick sinus syndrome. (12793721)
2003
18
Clinical significance of prolonged P wave width after right atrial appendage pacing in sick sinus syndrome. (12808263)
2003
19
Information from your family doctor. What you should know about sick sinus syndrome. (12725452)
2003
20
Comparison of the prothrombin levels between the patients with atrial fibrillation and patients with cardiac pacemaker implantation due to sick sinus syndrome during anticoagulation therapy with warfarin]. (12233104)
2002
21
Microvascular decompression for treating glossopharyngeal neuralgia complicated by sick sinus syndrome. (10819268)
2000
22
Optimal pacing mode for sick sinus syndrome. (10604909)
1999
23
Dynamic left ventricular arterial pressure gradient and sick sinus syndrome with heterozygous Fabry's disease improved following implantation of a dual chamber pacemaker. (10456648)
1999
24
Is an adenosine challenge a useful test for diagnosing sick sinus syndrome? (10047614)
1999
25
When should you suspect sick sinus syndrome? (10534891)
1999
26
Stroke in paced patients with sick sinus syndrome: relevance of atrial mechanical function, pacing mode and clinical characteristics. (9129848)
1997
27
Congenital defect of the left pericardium with sick sinus syndrome. (8969590)
1996
28
Prospective randomised trial of atrial versus ventricular pacing in sick-sinus syndrome. (7983951)
1994
29
Torsades de pointes in paced patients with sick sinus syndrome after disopyramide administration. (8022060)
1994
30
Repetitive atrial firing and fragmented atrial activity elicited by extrastimuli in the sick sinus syndrome with and without abnormal atrial electrograms. (8160717)
1994
31
Atrial adaptive rate pacing in sick sinus syndrome: effects on exercise capacity and arrhythmias. (8435244)
1993
32
Incidence and predictors of syncope in paced patients with sick sinus syndrome. (1279599)
1992
33
Comparison between ventricular inhibited pacing and physiologic pacing in sick sinus syndrome. (2006631)
1991
34
Clinical effects of oral theophylline in sick sinus syndrome. (1951001)
1991
35
The combined use of hysteresis and Holter functions improves diagnosis and therapy in patients with sick sinus syndrome. (2463536)
1988
36
The total heart beats per 24 hours by ambulatory electrocardiography and the changes of heart rate by treadmill exercise test in sick sinus syndrome. (3361700)
1988
37
Sick sinus syndrome. Report of a case with an unusual central nervous system symptom. (3701027)
1986
38
Sick sinus syndrome due to hypervagotonic state. (4055681)
1985
39
Arrhythmia quiz: sick sinus syndrome. (3849400)
1985
40
ECG of the month. Sick sinus syndrome. (6698873)
1984
41
Observations of the effect of arrhythmias on the cerebral function by recordings of 24-hour continuous electrocardiograms. Comparison between the sick sinus syndrome and atrio-ventricular block. (7131778)
1982
42
A study of the sick-sinus syndrome. (6898617)
1980
43
Sick sinus syndrome in childhood. (7459152)
1980
44
The sick sinus syndrome. (763088)
1979
45
Sick sinus syndrome: evaluation with ambulatory monitoring. (489036)
1979
46
Symptomatic improvement in a patient with sick sinus syndrome after the onset of stable atrial flutter. (95640)
1978
47
Characterisation of heart rate response to exercise in the sick sinus syndrome. (687493)
1978
48
Sick-sinus syndrome manifested during anesthesia. (1267212)
1976
49
Digitalis and the sick sinus syndrome. Clinical and electrophysiologic documentation of severe toxic effect on sinus node function. (1132120)
1975
50
Letter: Sick sinus syndrome. (1156763)
1975

Genetic Variations for Sick Sinus Syndrome

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Expression for genes affiliated with Sick Sinus Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for genes affiliated with Sick Sinus Syndrome

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 49PharmGKB, 12EMD Millipore
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Compounds for genes affiliated with Sick Sinus Syndrome

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1isoproterenol44 1111.6MYH6
2norepinephrine44 11 2412.5MYH6
3p000354410.2NPPB, NPPA
4hncs4410.2NPPB, NPPA
5ly 835834410.2NPPA, AGT
6alacepril4410.2NPPA, NPPB
7candoxatril44 1111.2NPPA, NPPB
8imidapril4410.2NPPA, NPPB
9benazepril44 1111.2AGT, NPPA
10urodilatin4410.2NPPA, NPPB
11trandolapril44 1111.1NPPB, NPPA
12inulin4410.1AGT, NPPA
13bisoprolol44 49 1112.1NPPA, NPPB
14hanp4410.1NPPB, NPPA
15dobutamine44 28 1112.1NPPB, NPPA
16fosinopril44 1111.1NPPB, NPPA
17moxonidine4410.1NPPB, NPPA
18hydroxyethyl starch4410.0NPPA, F2
19enalaprilat449.9NPPB, AGT, NPPA
20lisinopril44 11 2411.9NPPA, NPPB, AGT
218-bromo cgmp449.9AGT, NPPA, NPPB
22perindopril44 49 1111.9NPPB, NPPA, AGT
23enalapril44 49 1111.9NPPB, AGT, NPPA
24amlodipine44 49 11 2412.9NPPB, NPPA, AGT
25ang ii449.9AGT, NPPA, NPPB
26l-nmma449.9NPPA, NPPB, AGT
27phenylephrine44 28 11 2412.8NPPA, NPPB, AGT
28losartan44 49 28 1112.8NPPB, AGT, NPPA
29metoprolol44 28 49 11 2413.8NPPA, NPPB
30digoxin44 49 59 11 2413.8F2, NPPA, NPPB
31haloperidol44 28 2 49 1113.8AGT, NPPB, NPPA
32nppb44 59 2811.7NPPA, NPPB
33aprotinin44 1110.7AGT, NPPB, F2
34guanylate449.6NPPB, NPPA, AGT
35forskolin44 49 1111.6AGT, NPPA, NPPB
36homocysteine44 2410.5NPPB, F2, AGT
37mibg449.5NPPB, NPPA
38potassium44 11 2411.5HCN4, HCN2, NPPA, SCN5A, AGT
39epinephrine44 11 2411.4NPPA, NPPB, AGT, F2
40estradiol44 11 2411.4AGT, MYH6, NPPB, CYP27B1
41ivabradine289.3HCN1, HCN2, HCN4, HCN3
42zd7288289.3HCN1, HCN2, HCN4, HCN3
43zatebradine289.3HCN1, HCN3, HCN2, HCN4
44cilobradine289.3HCN2, HCN3, HCN1, HCN4
45cs+289.3HCN3, HCN2, HCN4, HCN1
46arginine449.2AGT, SCN5A, NPPA, NPPB, MYH6
47pge2449.2CYP27B1, AGT, NPPB, NPPA
48cyclosporin a44 28 5911.1NPPA, AGT, NPPB, F2
49cyclic amp44 249.7HCN3, CYP27B1, NPPA, HCN2, HCN4, HCN1
50sodium44 249.0AGT, HCN3, HCN1, HCN4, NPPB, HCN2

GO Terms for genes affiliated with Sick Sinus Syndrome

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16Gene Ontology
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Cellular components related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.1RGS6, F2, HCN3, HCN1, HCN4, HCN2

Biological processes related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0NPPA, NPPB
2receptor guanylyl cyclase signaling pathwayGO:00716810.0NPPA, NPPB
3regulation of heart contractionGO:00801610.0HCN4, MYH6
4cation transportGO:0068129.9HCN4, HCN2
5regulation of blood vessel sizeGO:0508809.9NPPA, NPPB
6positive regulation of renal sodium excretionGO:0358159.9AGT, NPPB
7muscle contractionGO:0069369.9MYH6, HCN2, HCN4
8regulation of heart rateGO:0020279.9SCN5A, MYH6
9regulation of blood pressureGO:0082179.8MYH6, NPPA, NPPB
10positive regulation of reactive oxygen species metabolic processGO:20003799.4F2, AGT
11negative regulation of cell growthGO:0303089.4NPPB, NPPA, AGT, CYP27B1
12potassium ion transmembrane transportGO:0718059.1HCN3, HCN1, HCN4, HCN2
13regulation of membrane potentialGO:0423919.1HCN2, HCN4, HCN1, HCN3
14synaptic transmissionGO:0072688.9HCN2, HCN4, HCN1, HCN3

Molecular functions related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cation channel activityGO:0052619.9HCN4, HCN2
2hormone activityGO:0051799.2AGT, NPPA, NPPB
3sodium channel activityGO:0052728.9HCN3, HCN1, HCN4, HCN2
4cAMP bindingGO:0305528.9HCN2, HCN4, HCN1, HCN3
5voltage-gated potassium channel activityGO:0052498.8HCN2, HCN4, HCN1, HCN3

Products for genes affiliated with Sick Sinus Syndrome

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Sources for Sick Sinus Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet