MCID: SCK002
MIFTS: 50

Sick Sinus Syndrome malady

Genetic diseases, Cardiovascular diseases, Rare diseases categories

Summaries for Sick Sinus Syndrome

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Genetics Home Reference:21 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards based summary: Sick Sinus Syndrome, also known as sinus node dysfunction, is related to sick sinus syndrome 2 and atrioventricular block. An important gene associated with Sick Sinus Syndrome is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are Cardiac Progenitor Differentiation and Cardiomyocyte Differentiation through BMP Receptors. The compounds p00035 and hncs have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related mouse phenotypes are muscle and normal.

Wikipedia:63 Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of... more...

Aliases & Classifications for Sick Sinus Syndrome

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Sick Sinus Syndrome, Aliases & Descriptions:

Name: Sick Sinus Syndrome 9 21 11 43 60
Sinus Node Dysfunction 21 60
Sinus Node Infection 9
 
Sinus Node Disease 21
Snd 21
Sss 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:13884
MeSH33 D012804
NCIt38 C62244
ICD1025 I49.5

Related Diseases for Sick Sinus Syndrome

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Diseases in the Sick Sinus Syndrome family:

Sick Sinus Syndrome 3 Sick Sinus Syndrome 1
Sick Sinus Syndrome 2 Familial Sick Sinus Syndrome

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1sick sinus syndrome 231.6HCN4
2atrioventricular block31.4NPPB, SCN5A
3atrial fibrillation31.2NPPA, NPPB, F2, SCN5A
4brugada syndrome31.2SCN5A, HCN4
5congenital heart disease30.5NPPA, NPPB
6coronary artery disease30.3AGT, NPPB, NPPA
7acute myocardial infarction30.3AGT, NPPA, NPPB
8myocardial infarction30.2AGT, NPPA, NPPB
9syncope10.8
10familial sick sinus syndrome10.7
11sick sinus syndrome 110.7
12sick sinus syndrome 310.6
13amyloidosis10.5
14brugada syndrome 110.5SCN5A
15mitral valve disease10.5NPPA
16familial atrial fibrillation10.4SCN5A
17thyrotoxicosis10.4
18isolated levocardia10.4
19central sleep apnea10.4NPPB
20catecholaminergic polymorphic ventricular tachycardia10.3
21dextrocardia10.3
22artery disease10.3
23pericarditis10.3
24myotonic dystrophy10.3
25polymyositis10.3
26levocardia10.3
27atrial heart septal defect10.3NPPB, MYH6
28mitral valve insufficiency10.3NPPB, NPPA
29mitral valve stenosis10.3NPPA, NPPB
30syndrome of inappropriate antidiuretic hormone10.3NPPA, NPPB
31cor pulmonale10.3NPPB, NPPA
32heart valve disease10.3NPPB, NPPA
33hypertensive heart disease10.2NPPB, NPPA
34idiopathic edema10.2NPPB, NPPA
35pulmonary hypertension10.2NPPB, NPPA
36sudden cardiac death multi-gene panels10.2SCN5A, MYH6, NPPB
37systemic lupus erythematosus10.2
38erdheim-chester disease10.2
39inferior myocardial infarction10.2
40long qt syndrome10.2
41lupus erythematosus10.2
42left ventricular noncompaction10.2
43limbic encephalitis10.2
44hepatorenal syndrome10.2F2, NPPA
45hypoparathyroidism-retardation-dysmorphism syndrome10.2
46hemochromatosis10.2
47hodgkin lymphoma10.2
48arteriovenous fistula10.2
49atherosclerosis10.2
50cataract10.2

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to sick sinus syndrome

Symptoms for Sick Sinus Syndrome

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Drugs & Therapeutics for Sick Sinus Syndrome

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Drug clinical trials:

Search ClinicalTrials for Sick Sinus Syndrome

Search NIH Clinical Center for Sick Sinus Syndrome

Genetic Tests for Sick Sinus Syndrome

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Anatomical Context for Sick Sinus Syndrome

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MalaCards organs/tissues related to Sick Sinus Syndrome:

31
Heart, Testes, Atrioventricular node, Spleen, Brain, B cells

Animal Models for Sick Sinus Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Sick Sinus Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7HCN4, SCN5A, MYH6, NPPA, NPPB, AGT
2MP:00028738.5PODXL, SCN5A, HCN4, HCN1, F2
3MP:00053767.9F2, CYP27B1, HCN4, PODXL, MYH6, NPPA
4MP:00107687.7F2, HCN2, HCN4, SCN5A, PODXL, MYH6
5MP:00036317.2F2, HCN1, HCN2, HCN3, SCN5A, PODXL
6MP:00053855.4AGT, F2, HCN1, HCN2, HCN3, HCN4

Publications for Sick Sinus Syndrome

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Articles related to Sick Sinus Syndrome:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Sick sinus syndrome and atrial fibrillation in older persons - A view from the sinoatrial nodal myocyte. (25668431)
2015
2
Health economic evaluation of single-lead atrial pacing vs. dual-chamber pacing in sick sinus syndrome. (24451290)
2014
3
Syncope in paced patients with sick sinus syndrome from the DANPACE trial: incidence, predictors and prognostic implication. (24711481)
2014
4
Isolated cardiac involvement in primary amyloidosis: presenting as sick sinus syndrome and heart failure. (24391340)
2013
5
Left atrial responses to acute right ventricular apical pacing in patients with sick sinus syndrome. (23822568)
2013
6
Sick sinus syndrome in a dog: treatment with dual-chambered pacemaker implantation. (23115373)
2012
7
Sick sinus syndrome associated with topical timolol maleate instillation. (22025865)
2011
8
Not so fast! Sick sinus syndrome is a complex and incompletely understood disease that might prove hard to model in animals. (21791463)
2011
9
Congenital sick sinus syndrome with atrial inexcitability and coronary sinus flutter. (22010118)
2011
10
Sick sinus syndrome with Alzheimer's disease for bilateral hernia repair. (21772702)
2011
11
Prevalence of the Brugada-type electrocardiogram and incidence of Brugada syndrome in patients with sick sinus syndrome. (20019410)
2010
12
Atrial size independently correlates with the development of paroxysmal atrial fibrillation in patients with sick sinus syndrome. (21199611)
2010
13
A patient with sick sinus syndrome, atrial flutter and bidirectional ventricular tachycardia: Coincident or concomitant presentations? (18651526)
2007
14
I was recently diagnosed with sick sinus syndrome. What is this exactly, and is it a serious condition? (17387777)
2007
15
Role of the low amplitude potential in the initial P wave signal-averaged electrocardiogram [corrected] in sick sinus syndrome. (16864929)
2006
16
Isolated noncompaction of left ventricular myocardium with fetal sustained bradycardia due to sick sinus syndrome. (17290580)
2006
17
A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. (15910881)
2005
18
Ebstein anomaly associated with unusual conduction delay and sick sinus syndrome. (15226641)
2004
19
Familial sick sinus syndrome complicated by extensive cardiac conduction disturbance. (15094010)
2004
20
Blood pressure variability in paced patients with sick sinus syndrome. (11918152)
2002
21
Physiologic atrial cardiac pacing for the prevention of chronic atrial fibrillation associated with sick sinus syndrome. (11814087)
2002
22
Regional myocardial blood flow in patients with sick sinus syndrome randomized to long-term single chamber atrial or dual chamber pacing--effect of pacing mode and rate. (10807447)
2000
23
Stroke in paced patients with sick sinus syndrome: influence of left atrial function and size. (10516407)
1999
24
AAI pacing for sick sinus syndrome: first choice on all counts. (9875100)
1998
25
Prospective randomised trial of atrial versus ventricular pacing in sick-sinus syndrome. (7983951)
1994
26
Atrial adaptive rate pacing in sick sinus syndrome: effects on exercise capacity and arrhythmias. (8435244)
1993
27
Update on sick sinus syndrome, a cardiac disorder of aging. (2403955)
1990
28
Sick sinus syndrome as a complication of mediastinal radiation therapy. (2337864)
1990
29
Cardiac electrophysiologic properties of intravenous isradipine in patients with sick sinus syndrome. (2523662)
1989
30
Long-term follow-up of patients with sick sinus syndrome: a comparison of clinical aspects among unpaced, ventricular inhibited paced, and physiologically paced groups. (2462243)
1988
31
Atrial pacing in the management of sick sinus syndrome: long-term observation for conduction disturbances and supraventricular tachyarrhythmias. (3699046)
1986
32
Sick sinus syndrome: the role of hypervagotonia. (6724752)
1984
33
Pacemaker treatment of sick sinus syndrome in children. (6833672)
1983
34
Comparative evaluation of depressed automaticity in sick sinus syndrome by Holter monitoring and overdrive suppression test. (6682281)
1983
35
Sinoatrial arrest due to lidocaine injection in sick sinus syndrome during amiodarone administration. (7148661)
1982
36
Polymyositis presenting as sick sinus syndrome. (7122376)
1982
37
A clinicopathologic study on sick sinus syndrome with histological approach to the sinoatrial node. (7401276)
1980
38
Effect of verapamil on normal sinoatrial node function and on sick sinus syndrome. (717239)
1978
39
The sick sinus syndrome. A study of 50 cases. (621450)
1978
40
Symptomatic improvement in a patient with sick sinus syndrome after the onset of stable atrial flutter. (95640)
1978
41
Sick sinus syndrome due to cardiac amyloidosis. (657173)
1978
42
A case of supraventricular tachycardia in an infant probably due to sick sinus syndrome. (913311)
1977
43
Treatment of sick sinus syndrome with permanent cardiac pacemaker. (Sick sinus syndrome and artificial pacemaker). (591551)
1977
44
Clinical spectrum of the sick sinus syndrome. (836172)
1977
45
Sick sinus syndrome. (1047966)
1976
46
"Paradoxical" prolongation of sinus nodal recovery time after atropine in the sick sinus syndrome. (1146702)
1975
47
Sick sinus syndrome. Symptomatic cases in children. (1211960)
1975
48
Letter: Sick sinus syndrome. (1174896)
1975
49
Sick sinus syndrome: experience of a cardiac pacemaker clinic. (4415767)
1974
50
Appraisal of sinus nodal recovery time in patients with sick sinus syndrome. (4850629)
1974

Variations for Sick Sinus Syndrome

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Clinvar genetic disease variations for Sick Sinus Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1SCN5ANM_000335.4(SCN5A): c.5347G> A (p.Glu1783Lys)single nucleotide variantPathogenicrs137854601GRCh37Chr 3, 38592513: 38592513

Expression for genes affiliated with Sick Sinus Syndrome

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Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for genes affiliated with Sick Sinus Syndrome

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Compounds for genes affiliated with Sick Sinus Syndrome

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Compounds related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1p000354310.2NPPA, NPPB
2hncs4310.2NPPA, NPPB
3candoxatril43 1211.2NPPA, NPPB
4alacepril4310.1NPPA, NPPB
5ly 835834310.1AGT, NPPA
6imidapril43 4911.1NPPA, NPPB
7urodilatin4310.1NPPB, NPPA
8hanp4310.1NPPA, NPPB
9bisoprolol43 49 1212.0NPPB, NPPA
10inulin4310.0NPPA, AGT
11trandolapril43 1211.0NPPB, NPPA
12moxonidine439.8NPPA, NPPB
13enalaprilat439.8AGT, NPPB, NPPA
14lisinopril43 49 24 1212.8NPPA, NPPB, AGT
158-bromo cgmp439.8AGT, NPPA, NPPB
16perindopril43 49 1211.8NPPA, AGT, NPPB
17enalapril43 49 1211.8AGT, NPPB, NPPA
18amlodipine43 49 24 1212.8AGT, NPPB, NPPA
19captopril43 59 49 28 1213.8AGT, NPPA, NPPB
20ang ii439.8AGT, NPPB, NPPA
21l-nmma439.8NPPB, NPPA, AGT
22dobutamine43 28 49 1212.8NPPB, NPPA
23phenylephrine43 28 24 1212.8NPPA, NPPB, AGT
24losartan43 49 28 1212.7NPPB, NPPA, AGT
25hydroxyethyl starch439.7NPPA, F2
26digoxin43 59 49 24 1213.7NPPB, NPPA, F2
27haloperidol43 49 28 2 1213.7NPPB, AGT, NPPA
28fosinopril43 1210.7NPPA, NPPB
29aprotinin43 1210.6NPPB, F2, AGT
30guanylate439.6AGT, NPPA, NPPB
31isoproterenol43 1210.5NPPB, MYH6, AGT, NPPA
32benazepril43 49 1211.5NPPA, AGT
33norepinephrine43 24 1211.5AGT, NPPA, MYH6, NPPB
34homocysteine43 2410.5F2, NPPB, AGT
35estradiol43 24 1211.4CYP27B1, NPPB, AGT, MYH6
36forskolin43 49 1211.4NPPB, CYP27B1, NPPA, AGT
37potassium43 24 1211.4AGT, NPPA, HCN2, HCN4, SCN5A
38epinephrine43 24 1211.3NPPA, F2, AGT, NPPB
39arginine439.2AGT, NPPB, NPPA, MYH6, SCN5A
40cyclosporin a43 28 5911.2F2, NPPB, AGT, NPPA
41pge2439.2AGT, CYP27B1, NPPA, NPPB
42oxygen43 2410.0NPPA, MYH6, CYP27B1, AGT, NPPB
43ivabradine289.0HCN4, HCN1, HCN2, HCN3
44zatebradine289.0HCN1, HCN2, HCN3, HCN4
45cilobradine289.0HCN4, HCN3, HCN2, HCN1
46zd7288289.0HCN4, HCN3, HCN1, HCN2
47cs+289.0HCN1, HCN4, HCN3, HCN2
48estrogen438.9F2, CYP27B1, MYH6, NPPB, NPPA
49cyclic amp43 249.3HCN4, NPPA, HCN3, HCN2, HCN1, CYP27B1
50sodium43 248.6AGT, SCN5A, NPPA, HCN1, NPPB, HCN4

GO Terms for genes affiliated with Sick Sinus Syndrome

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Cellular components related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.0PODXL, HCN4, HCN3, HCN2, HCN1
2plasma membraneGO:00058866.4RGS6, F2, HCN1, HCN2, HCN3, HCN4

Biological processes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cellular response to cGMPGO:007132110.0HCN2, HCN4
2cGMP biosynthetic processGO:00061829.9NPPB, NPPA
3regulation of heart rateGO:00020279.9HCN4, SCN5A, MYH6
4receptor guanylyl cyclase signaling pathwayGO:00071689.8NPPB, NPPA
5regulation of blood vessel sizeGO:00508809.8NPPA, NPPB
6regulation of blood pressureGO:00082179.7NPPB, NPPA, MYH6
7positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.6AGT, F2
8positive regulation of renal sodium excretionGO:00358159.6NPPB, AGT
9positive regulation of reactive oxygen species metabolic processGO:020003799.3AGT, F2
10negative regulation of cell growthGO:00303089.3AGT, NPPB, NPPA, CYP27B1
11cellular response to cAMPGO:00713208.8HCN1, HCN2, HCN3, HCN4
12potassium ion transmembrane transportGO:00718058.8HCN1, HCN2, HCN3, HCN4
13regulation of membrane potentialGO:00423918.8HCN1, HCN2, HCN3, HCN4
14synaptic transmissionGO:00072688.6HCN1, HCN2, HCN3, HCN4
15sodium ion transmembrane transportGO:00357258.6SCN5A, HCN4, HCN3, HCN2, HCN1

Molecular functions related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.3NPPB, NPPA, F2
2intracellular cAMP activated cation channel activityGO:00052229.2HCN4, HCN2, HCN1
3hormone activityGO:00051799.1NPPA, NPPB, AGT
4cAMP bindingGO:00305528.6HCN1, HCN2, HCN3, HCN4
5voltage-gated potassium channel activityGO:00052498.5HCN1, HCN2, HCN3, HCN4
6voltage-gated sodium channel activityGO:00052488.4SCN5A, HCN4, HCN3, HCN2, HCN1

Products for genes affiliated with Sick Sinus Syndrome

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Sources for Sick Sinus Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
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45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet