SND
MCID: SCK002
MIFTS: 57

Sick Sinus Syndrome (SND) malady

Genetic diseases, Cardiovascular diseases, Rare diseases categories

Summaries for Sick Sinus Syndrome

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Genetics Home Reference:22 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards based summary: Sick Sinus Syndrome, also known as sinus node dysfunction, is related to sick sinus syndrome 2 and atrioventricular block. An important gene associated with Sick Sinus Syndrome is SCN5A (sodium channel, voltage-gated, type V, alpha subunit), and among its related pathways are Cardiac Progenitor Differentiation and Cardiomyocyte Differentiation through BMP Receptors. The compounds p00035 and hncs have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related mouse phenotypes are muscle and normal.

Wikipedia:64 Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of... more...

Aliases & Classifications for Sick Sinus Syndrome

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Sick Sinus Syndrome, Aliases & Descriptions:

Name: Sick Sinus Syndrome 9 22 11 44 61
Sinus Node Dysfunction 22 61
Sinus Node Disease 22
 
Snd 22
Sss 22


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:13884
MeSH34 D012804
NCIt39 C62244
ICD1026 I49.5

Related Diseases for Sick Sinus Syndrome

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Diseases in the Sick Sinus Syndrome 2 family:

sick sinus syndrome Sick Sinus Syndrome 2, Autosomal Dominant
Sick Sinus Syndrome 1, Autosomal Recessive Sick Sinus Syndrome 1
Sick Sinus Syndrome 3

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1sick sinus syndrome 231.6HCN4
2atrioventricular block31.4SCN5A, NPPB
3brugada syndrome31.2HCN4, SCN5A
4congenital heart disease30.5NPPB, NPPA
5coronary artery anomaly30.3AGT, NPPB, NPPA
6acute myocardial infarction30.3NPPA, NPPB, AGT
7myocardial infarction30.2AGT, NPPB, NPPA
8diabetes mellitus30.1CYP27B1, NPPA, NPPB, AGT
9syncope10.8
10amyloidosis10.6
11sick sinus syndrome 110.5
12brugada syndrome 110.5SCN5A
13mitral valve disease10.5NPPA
14sick sinus syndrome 310.4
15familial atrial fibrillation10.4SCN5A
16central sleep apnea10.4NPPB
17thyrotoxicosis10.4
18isolated levocardia10.4
19sick sinus syndrome 2, autosomal dominant10.4
20sick sinus syndrome 1, autosomal recessive10.4
21sinus node disease and myopia10.4
22catecholaminergic polymorphic ventricular tachycardia10.3
23parkinson's disease10.3
24dextrocardia10.3
25artery disease10.3
26pericarditis10.3
27myotonic dystrophy10.3
28polymyositis10.3
29thromboembolism10.3
30levocardia10.3
31atrial heart septal defect10.3MYH6, NPPB
32syndrome of inappropriate antidiuretic hormone10.3NPPA, NPPB
33mitral valve insufficiency10.3NPPA, NPPB
34mitral valve stenosis10.3NPPA, NPPB
35cor pulmonale10.3NPPB, NPPA
36heart valve disease10.3NPPB, NPPA
37hypertensive heart disease10.3NPPA, NPPB
38idiopathic edema10.2NPPA, NPPB
39hypoparathyroidism-retardation-dysmorphism syndrome10.2
40primary pulmonary hypertension10.2NPPB, NPPA
41sudden cardiac death multi-gene panels10.2SCN5A, MYH6, NPPB
42hepatorenal syndrome10.2F2, NPPA
43systemic lupus erythematosus10.2
44inferior myocardial infarction10.2
45long qt syndrome10.2
46lupus erythematosus10.2
47left ventricular noncompaction10.2
48limbic encephalitis10.2
49alzheimer's disease10.1
50arteriovenous fistula10.1

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to sick sinus syndrome

Symptoms for Sick Sinus Syndrome

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Drugs & Therapeutics for Sick Sinus Syndrome

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Drug clinical trials:

Search ClinicalTrials for Sick Sinus Syndrome

Search NIH Clinical Center for Sick Sinus Syndrome

Genetic Tests for Sick Sinus Syndrome

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Anatomical Context for Sick Sinus Syndrome

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MalaCards organs/tissues related to Sick Sinus Syndrome:

32
Heart, Testes, Atrioventricular node, Spleen, Brain, B cells

Animal Models for Sick Sinus Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Sick Sinus Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7HCN4, SCN5A, MYH6, NPPA, NPPB, AGT
2MP:00028738.5PODXL, SCN5A, HCN4, HCN1, F2
3MP:00053767.9F2, CYP27B1, HCN4, PODXL, MYH6, NPPA
4MP:00107687.7F2, HCN2, HCN4, SCN5A, PODXL, MYH6
5MP:00036317.2F2, HCN1, HCN2, HCN3, SCN5A, PODXL
6MP:00053855.4AGT, F2, HCN1, HCN2, HCN3, HCN4

Publications for Sick Sinus Syndrome

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Articles related to Sick Sinus Syndrome:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Health economic evaluation of single-lead atrial pacing vs. dual-chamber pacing in sick sinus syndrome. (24451290)
2014
2
Syncope in paced patients with sick sinus syndrome from the DANPACE trial: incidence, predictors and prognostic implication. (24711481)
2014
3
Isolated cardiac involvement in primary amyloidosis: presenting as sick sinus syndrome and heart failure. (24391340)
2013
4
Left atrial responses to acute right ventricular apical pacing in patients with sick sinus syndrome. (23822568)
2013
5
Sick sinus syndrome in a dog: treatment with dual-chambered pacemaker implantation. (23115373)
2012
6
Sick sinus syndrome associated with topical timolol maleate instillation. (22025865)
2011
7
Not so fast! Sick sinus syndrome is a complex and incompletely understood disease that might prove hard to model in animals. (21791463)
2011
8
Congenital sick sinus syndrome with atrial inexcitability and coronary sinus flutter. (22010118)
2011
9
Sick sinus syndrome with Alzheimer's disease for bilateral hernia repair. (21772702)
2011
10
Prevalence of the Brugada-type electrocardiogram and incidence of Brugada syndrome in patients with sick sinus syndrome. (20019410)
2010
11
Atrial size independently correlates with the development of paroxysmal atrial fibrillation in patients with sick sinus syndrome. (21199611)
2010
12
A patient with sick sinus syndrome, atrial flutter and bidirectional ventricular tachycardia: Coincident or concomitant presentations? (18651526)
2007
13
I was recently diagnosed with sick sinus syndrome. What is this exactly, and is it a serious condition? (17387777)
2007
14
Role of the low amplitude potential in the initial P wave signal-averaged electrocardiogram [corrected] in sick sinus syndrome. (16864929)
2006
15
Isolated noncompaction of left ventricular myocardium with fetal sustained bradycardia due to sick sinus syndrome. (17290580)
2006
16
A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. (15910881)
2005
17
Ebstein anomaly associated with unusual conduction delay and sick sinus syndrome. (15226641)
2004
18
Familial sick sinus syndrome complicated by extensive cardiac conduction disturbance. (15094010)
2004
19
Blood pressure variability in paced patients with sick sinus syndrome. (11918152)
2002
20
Physiologic atrial cardiac pacing for the prevention of chronic atrial fibrillation associated with sick sinus syndrome. (11814087)
2002
21
Regional myocardial blood flow in patients with sick sinus syndrome randomized to long-term single chamber atrial or dual chamber pacing--effect of pacing mode and rate. (10807447)
2000
22
Stroke in paced patients with sick sinus syndrome: influence of left atrial function and size. (10516407)
1999
23
AAI pacing for sick sinus syndrome: first choice on all counts. (9875100)
1998
24
Prospective randomised trial of atrial versus ventricular pacing in sick-sinus syndrome. (7983951)
1994
25
Atrial adaptive rate pacing in sick sinus syndrome: effects on exercise capacity and arrhythmias. (8435244)
1993
26
Update on sick sinus syndrome, a cardiac disorder of aging. (2403955)
1990
27
Sick sinus syndrome as a complication of mediastinal radiation therapy. (2337864)
1990
28
Cardiac electrophysiologic properties of intravenous isradipine in patients with sick sinus syndrome. (2523662)
1989
29
Long-term follow-up of patients with sick sinus syndrome: a comparison of clinical aspects among unpaced, ventricular inhibited paced, and physiologically paced groups. (2462243)
1988
30
Atrial pacing in the management of sick sinus syndrome: long-term observation for conduction disturbances and supraventricular tachyarrhythmias. (3699046)
1986
31
Syncope in the elderly. Report of 3 cases with sick sinus syndrome. (3704847)
1986
32
Sick sinus syndrome: the role of hypervagotonia. (6724752)
1984
33
Suspected sick sinus syndrome in an infant treated by pacemaker implantation. (6473126)
1984
34
Pacemaker treatment of sick sinus syndrome in children. (6833672)
1983
35
Comparative evaluation of depressed automaticity in sick sinus syndrome by Holter monitoring and overdrive suppression test. (6682281)
1983
36
Sinoatrial arrest due to lidocaine injection in sick sinus syndrome during amiodarone administration. (7148661)
1982
37
Polymyositis presenting as sick sinus syndrome. (7122376)
1982
38
A clinicopathologic study on sick sinus syndrome with histological approach to the sinoatrial node. (7401276)
1980
39
Effect of verapamil on normal sinoatrial node function and on sick sinus syndrome. (717239)
1978
40
The sick sinus syndrome. A study of 50 cases. (621450)
1978
41
Symptomatic improvement in a patient with sick sinus syndrome after the onset of stable atrial flutter. (95640)
1978
42
Sick sinus syndrome due to cardiac amyloidosis. (657173)
1978
43
A case of supraventricular tachycardia in an infant probably due to sick sinus syndrome. (913311)
1977
44
Treatment of sick sinus syndrome with permanent cardiac pacemaker. (Sick sinus syndrome and artificial pacemaker). (591551)
1977
45
Clinical spectrum of the sick sinus syndrome. (836172)
1977
46
Sick sinus syndrome. (1047966)
1976
47
"Paradoxical" prolongation of sinus nodal recovery time after atropine in the sick sinus syndrome. (1146702)
1975
48
Sick sinus syndrome. Symptomatic cases in children. (1211960)
1975
49
Letter: Sick sinus syndrome. (1174896)
1975
50
Sick sinus syndrome: experience of a cardiac pacemaker clinic. (4415767)
1974

Variations for Sick Sinus Syndrome

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Clinvar genetic disease variations for Sick Sinus Syndrome:

7
id Gene Name Type Significance SNP ID Assembly Location
1SCN5ANM_000335.4(SCN5A): c.5347G> A (p.Glu1783Lys)single nucleotide variantPathogenicrs137854601GRCh37Chr 3, 38592513: 38592513

Expression for genes affiliated with Sick Sinus Syndrome

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Expression patterns in normal tissues for genes affiliated with Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for genes affiliated with Sick Sinus Syndrome

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Pathways related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MYH6, SCN5A
29.8NPPB, NPPA
39.6SCN5A, HCN4, HCN2
49.4AGT, NPPB, NPPA
58.5HCN1, HCN2, HCN3, HCN4
6
Show member pathways
8.5HCN1, HCN2, HCN3, HCN4
7
Show member pathways
8.5HCN4, HCN3, HCN2, HCN1
8
Show member pathways
8.3SCN5A, HCN4, HCN3, HCN2, HCN1
9
Show member pathways
8.2HCN1, HCN2, HCN3, HCN4, MYH6

Compounds for genes affiliated with Sick Sinus Syndrome

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Compounds related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1p000354410.2NPPA, NPPB
2hncs4410.2NPPA, NPPB
3candoxatril44 1211.2NPPA, NPPB
4alacepril4410.1NPPA, NPPB
5ly 835834410.1AGT, NPPA
6imidapril44 5011.1NPPA, NPPB
7urodilatin4410.1NPPB, NPPA
8hanp4410.1NPPA, NPPB
9bisoprolol44 50 1212.0NPPB, NPPA
10inulin4410.0NPPA, AGT
11trandolapril44 1211.0NPPB, NPPA
12moxonidine449.8NPPA, NPPB
13enalaprilat449.8AGT, NPPB, NPPA
14lisinopril44 50 25 1212.8NPPA, NPPB, AGT
158-bromo cgmp449.8AGT, NPPA, NPPB
16perindopril44 50 1211.8NPPA, AGT, NPPB
17enalapril44 50 1211.8AGT, NPPB, NPPA
18amlodipine44 50 25 1212.8AGT, NPPB, NPPA
19captopril44 60 50 29 1213.8AGT, NPPA, NPPB
20ang ii449.8AGT, NPPB, NPPA
21l-nmma449.8NPPB, NPPA, AGT
22dobutamine44 29 50 1212.8NPPB, NPPA
23phenylephrine44 29 25 1212.8NPPA, NPPB, AGT
24losartan44 50 29 1212.7NPPB, NPPA, AGT
25hydroxyethyl starch449.7NPPA, F2
26digoxin44 60 50 25 1213.7NPPB, NPPA, F2
27haloperidol44 50 29 3 1213.7NPPB, AGT, NPPA
28fosinopril44 1210.7NPPA, NPPB
29aprotinin44 1210.6NPPB, F2, AGT
30guanylate449.6AGT, NPPA, NPPB
31isoproterenol44 1210.5NPPB, MYH6, AGT, NPPA
32benazepril44 50 1211.5NPPA, AGT
33norepinephrine44 25 1211.5AGT, NPPA, MYH6, NPPB
34homocysteine44 2510.5F2, NPPB, AGT
35estradiol44 25 1211.4CYP27B1, NPPB, AGT, MYH6
36forskolin44 50 1211.4NPPB, CYP27B1, NPPA, AGT
37potassium44 25 1211.4AGT, NPPA, HCN2, HCN4, SCN5A
38epinephrine44 25 1211.3NPPA, F2, AGT, NPPB
39arginine449.2AGT, NPPB, NPPA, MYH6, SCN5A
40cyclosporin a44 29 6011.2F2, NPPB, AGT, NPPA
41pge2449.2AGT, CYP27B1, NPPA, NPPB
42oxygen44 2510.0NPPA, MYH6, CYP27B1, AGT, NPPB
43ivabradine299.0HCN4, HCN1, HCN2, HCN3
44zatebradine299.0HCN1, HCN2, HCN3, HCN4
45cilobradine299.0HCN4, HCN3, HCN2, HCN1
46zd7288299.0HCN4, HCN3, HCN1, HCN2
47cs+299.0HCN1, HCN4, HCN3, HCN2
48estrogen448.9F2, CYP27B1, MYH6, NPPB, NPPA
49cyclic amp44 259.3HCN4, NPPA, HCN3, HCN2, HCN1, CYP27B1
50sodium44 258.6AGT, SCN5A, NPPA, HCN1, NPPB, HCN4

GO Terms for genes affiliated with Sick Sinus Syndrome

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Cellular components related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.0PODXL, HCN4, HCN3, HCN2, HCN1
2plasma membraneGO:0058866.4RGS6, F2, HCN1, HCN2, HCN3, HCN4

Biological processes related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1cellular response to cGMPGO:07132110.0HCN2, HCN4
2cGMP biosynthetic processGO:0061829.9NPPB, NPPA
3regulation of heart rateGO:0020279.9HCN4, SCN5A, MYH6
4receptor guanylyl cyclase signaling pathwayGO:0071689.8NPPB, NPPA
5regulation of blood vessel sizeGO:0508809.8NPPA, NPPB
6regulation of blood pressureGO:0082179.7NPPB, NPPA, MYH6
7positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6AGT, F2
8positive regulation of renal sodium excretionGO:0358159.6NPPB, AGT
9positive regulation of reactive oxygen species metabolic processGO:20003799.3AGT, F2
10negative regulation of cell growthGO:0303089.3AGT, NPPB, NPPA, CYP27B1
11cellular response to cAMPGO:0713208.8HCN1, HCN2, HCN3, HCN4
12potassium ion transmembrane transportGO:0718058.8HCN1, HCN2, HCN3, HCN4
13regulation of membrane potentialGO:0423918.8HCN1, HCN2, HCN3, HCN4
14synaptic transmissionGO:0072688.6HCN1, HCN2, HCN3, HCN4
15sodium ion transmembrane transportGO:0357258.6SCN5A, HCN4, HCN3, HCN2, HCN1

Molecular functions related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3NPPB, NPPA, F2
2intracellular cAMP activated cation channel activityGO:0052229.2HCN4, HCN2, HCN1
3hormone activityGO:0051799.1NPPA, NPPB, AGT
4cAMP bindingGO:0305528.6HCN1, HCN2, HCN3, HCN4
5voltage-gated potassium channel activityGO:0052498.5HCN1, HCN2, HCN3, HCN4
6voltage-gated sodium channel activityGO:0052488.4SCN5A, HCN4, HCN3, HCN2, HCN1

Products for genes affiliated with Sick Sinus Syndrome

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Sources for Sick Sinus Syndrome

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4CDC
14ExPASy
15FMA
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26ICD10
27ICD10 via Orphanet
28ICD9CM
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30KEGG
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