Sick Sinus Syndrome malady

Wikipedia: Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of...⁴⁴ more...

MalaCards: Sick Sinus Syndrome is related to sinusitis and brugada syndrome. An important gene associated with Sick Sinus Syndrome is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are Sodium channels and transporters- inward current and Antiarrhythmic Pathway, Pharmacodynamics. The compounds lidocaine and tirofiban have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related mouse phenotypes are muscle and cardiovascular system.

Aliases & Descriptions:

sick sinus syndrome 6 7 8 32 43

Disease types for sick sinus syndrome family:

sick sinus syndrome 1	sick sinus syndrome 2

Diseases related to sick sinus syndrome by text searches and GeneDecks gene sharing:

(show all 46)

id	Related Disease	Score	Top Affiliating Genes
1	sinusitis	30.5	MYH6, NPPB, HCN4, F2, ANK2, SCN5A
2	brugada syndrome	29.0	HCN4, ANK2, SCN5A
3	atrial fibrillation	28.4	NPPB, HCN4, F2, ANK2, SCN5A
4	right bundle branch block	13.0	HCN4, SCN5A
5	resting heart rate	12.8	SCN5A, MYH6
6	fainting	12.7	SCN5A, HCN4
7	catecholaminergic polymorphic ventricular tachycardia	12.6	SCN5A, NPPB
8	congenital heart block	12.6	SCN5A, NPPB
9	arrhythmogenic right ventricular dysplasia	12.5	SCN5A, NPPB
10	atrial heart septal defect	12.5	NPPB, MYH6
11	congenital heart defect	12.4	NPPB, MYH6
12	sleep disorder	12.4	NPPB, MYH6
13	long qt syndrome	12.4	SCN5A, ANK2, HCN4
14	familial hypertrophic cardiomyopathy	12.4	NPPB, MYH6
15	cryoglobulinemia	12.4	NPPB, F2
16	pulmonary embolism	12.3	F2, NPPB
17	primary pulmonary hypertension	12.3	NPPB, F2
18	pulmonary edema	12.2	NPPB, F2
19	ventricular fibrillation	12.2	SCN5A, HCN4, NPPB
20	duchenne muscular dystrophy	12.1	F2, NPPB
21	hypertrophic cardiomyopathy	12.0	HCN4, NPPB, MYH6
22	sudden cardiac death multi-gene panels	12.0	SCN5A, ANK2, NPPB
23	myocarditis	12.0	F2, NPPB, MYH6
24	hypothyroidism	11.9	MYH6, NPPB, F2
25	acute myocardial infarction	11.9	NPPB, F2, SCN5A
26	cadasil	11.9	MYH6, NPPB, F2
27	beta thalassemia	11.9	NPPB, F2, ANK2
28	thalassemia	11.9	ANK2, F2, NPPB
29	convulsions	11.8	F2, NPPB
30	twinning	11.8	SCN5A, F2, NPPB
31	congestive heart failure	11.6	MYH6, NPPB, F2, SCN5A
32	dmd-associated dilated cardiomyopathy	11.5	MYH6, NPPB, F2, SCN5A
33	vascular disease	11.5	F2, NPPB, MYH6
34	ischemia	11.4	SCN5A, F2, NPPB, MYH6
35	noonan syndrome	11.2	MYH6, NPPB, HCN4, F2, SCN5A
36	syncope	11.1	MYH6, NPPB, HCN4, ANK2, SCN5A
37	arrhythmogenic right ventricular dysplasia/cardiomyopathy multi-gene panels	11.1	SCN5A, ANK2, HCN4, NPPB, MYH6
38	neuroblastoma	11.1	NPPB, F2, ANK2, SCN5A
39	myocardial infarction	10.9	MYH6, NPPB, F2, ANK2, SCN5A
40	sick sinus syndrome 1, autosomal recessive	8.4
41	sick sinus syndrome 2, autosomal dominant	8.4
42	sick sinus syndrome 2	8.4
43	sick sinus syndrome 1	8.4
44	ventricular tachycardia	7.8
45	conduction disease	6.9
46	conduct disorder	6.9

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to sick sinus syndrome:

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MGI Mouse Phenotypes related to sick sinus syndrome:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	8.1	SCN5A, HCN4, NPPB, MYH6
2	cardiovascular system phenotype	MP:0005385	INF	SCN5A, MYH6, NPPB, HCN4, F2,

Articles related to sick sinus syndrome:

id	Title	Authors	Year	Affiliating Genes
1	A rare variant in MYH6 is associated with high risk o f sick sinus syndrome. (21378987)	Holm H.... Stefansson K.	2011	MYH6
2	Multiple loss-of-function mechanisms contribute to SC N5A-related familial sick sinus syndrome. (20539757)	Gui J.... Lei M.	2010	SCN5A
3	Sick sinus syndrome, progressive cardiac conduction d isease, atrial flutter and ventricular tachycardia caused by a novel SCN5A muta tion. (20395683)	Holst A.G.... Tfelt-Hansen J.	2010	SCN5A
4	Mutation-specific effects of polymorphism H558R in SC N5A-related sick sinus syndrome. (20384651)	Gui J.... Lei M.	2010	SCN5A
5	A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia. (17897635)	Tan B.H.... Makielski J.C.	2007	SCN5A
6	A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. (15910881)	Smits J.P.... Wilde A.A.	2005	SCN5A
7	Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). (14523039)	Benson D.W.... George A.L. Jr.	2003	SCN5A
8	Comparison of the prothrombin levels between the patients with atrial fibrillation and patients with cardiac pacemaker implantation due to sick sinus syndrome during anticoagulation therapy with warfarin (12233104)	Iwahashi H.... Morita T.	2002	F2
9	Brain natriuretic peptide predicts chronic atrial fibrillation after ventricular pacing in patients with sick sinus syndrome. (11194292)	Horie H.... Kinoshita M.	2000	NPPB

Genes related to sick sinus syndrome according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	11.1	Summaries
2	SCN5A	sodium channel, voltage-gated, type V, alpha subunit	11.0	Publications
3	MYH6	myosin, heavy chain 6, cardiac muscle, alpha	11.0	Publications
4	NPPB	natriuretic peptide B	11.0	Publications
5	F2	coagulation factor II (thrombin)	11.0	Publications

Pathways related to sick sinus syndrome according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Sodium channels and transporters- inward current10	9.5	SCN5A, HCN4
2	Antiarrhythmic Pathway, Pharmacodynamics34	INF	SCN5A, , HCN4

Compounds related to sick sinus syndrome according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	lidocaine32 9 9	11.6	SCN5A, F2
2	tirofiban32 9 9	11.3	F2, NPPB
3	amiodarone32 9 9	11.3	NPPB, F2
4	digoxin32 42 34 9 18 9	14.2	F2, NPPB
5	dipyridamole42 32 9 9	12.2	NPPB, F2
6	triiodothyronine32	8.9	NPPB, MYH6
7	aprotinin32 9 9	10.8	NPPB, F2
8	sodium32 18	9.7	SCN5A, HCN4, NPPB
9	serine32	8.0	SCN5A, F2, NPPB, MYH6
10	ryanodine32	INF	, NPPB, MYH6

Cellular components related to sick sinus syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Z disc	GO:030018	INF	, MYH6
2	intercalated disc	GO:014704	INF	SCN5A,
3	T-tubule	GO:030315	INF	SCN5A,
4	sarcolemma	GO:042383	INF	SCN5A,

Biological processes related to sick sinus syndrome according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	muscle contraction	GO:006936	9.4	HCN4, MYH6
2	regulation of heart contraction	GO:008016	9.3	HCN4, MYH6
3	regulation of blood pressure	GO:008217	8.7	NPPB, MYH6
4	SA node cardiomyocyte to atrial cardiomyocyte communication	GO:086070	INF	SCN5A,
5	regulation of heart rate by cardiac conduction	GO:086091	INF	SCN5A,
6	regulation of ventricular cardiac muscle cell action potential	GO:086005	INF	SCN5A,
7	regulation of heart rate	GO:002027	INF	SCN5A, , MYH6
8	regulation of ventricular cardiomyocyte membrane repolarization	GO:060307	INF	, SCN5A

Molecular functions related to sick sinus syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ion channel binding	GO:044325	INF	SCN5A,