MCID: SCK002
MIFTS: 50

Sick Sinus Syndrome

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Sick Sinus Syndrome

MalaCards integrated aliases for Sick Sinus Syndrome:

Name: Sick Sinus Syndrome 12 25 29 52 42 14 69
Sinus Node Dysfunction 25 69
Sinus Node Disease 25 29
Sinus Node Infection 12
Sss 25
Snd 25

Classifications:



External Ids:

Disease Ontology 12 DOID:13884
ICD10 33 I49.5
MeSH 42 D012804
NCIt 47 C62244
UMLS 69 C0037052

Summaries for Sick Sinus Syndrome

Genetics Home Reference : 25 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards based summary : Sick Sinus Syndrome, also known as sinus node dysfunction, is related to sinoatrial node disease and sick sinus syndrome 3. An important gene associated with Sick Sinus Syndrome is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Adipogenesis and Antiarrhythmic Pathway, Pharmacodynamics. The drugs Amiodarone and Propafenone have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are cardiovascular system and behavior/neurological

Wikipedia : 72 Sick sinus syndrome (SSS), also called sinus dysfunction, or sinoatrial node disease (\"SND\"), is a... more...

Related Diseases for Sick Sinus Syndrome

Diseases in the Sick Sinus Syndrome family:

Sick Sinus Syndrome 1 Sick Sinus Syndrome 3
Sick Sinus Syndrome 2 Sick Sinus Syndrome 2, Autosomal Dominant
Sick Sinus Syndrome 1, Autosomal Recessive Familial Sick Sinus Syndrome

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 sinoatrial node disease 30.1 HCN4 LMNA
2 sick sinus syndrome 3 12.3
3 sick sinus syndrome 1 12.3
4 sick sinus syndrome 2 12.3
5 familial sick sinus syndrome 12.2
6 sinus node disease and myopia 12.0
7 sick sinus syndrome 2, autosomal dominant 12.0
8 sick sinus syndrome 1, autosomal recessive 12.0
9 isolated levocardia 11.3
10 chronic atrial and intestinal dysrhythmia 11.2
11 cardiac arrhythmia, ankyrin-b-related 10.9
12 language delay and adhd/cognitive impairment with or without cardiac arrhythmia 10.9
13 endocardium disease 10.6 HCN4 SCN5A
14 lipodystrophy, familial partial, type 5 10.6 HCN4 SCN5A
15 uterine fibroid 10.5 HCN4 SCN5A
16 mylk-related thoracic aortic aneurysms and aortic dissections 10.5 LMNA SCN5A
17 sdccag8-related bardet-biedl syndrome 10.5 LMNA SCN5A
18 sdha-related hereditary paraganglioma-pheochromocytoma syndrome 10.5 LMNA SCN5A
19 atrial fibrillation 10.4
20 atrial standstill, digenic 10.4 LMNA SCN5A
21 sudden infant death syndrome 10.3 LMNA SCN5A
22 syncope 10.3
23 hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation 10.3 MYH6 SCN5A
24 optic nerve disease 10.3 F2 MYH6
25 atrioventricular block 10.2
26 second-degree atrioventricular block 10.2 HCN4 LMNA SCN5A
27 ulcerative stomatitis 10.2 AGT F2
28 chicken egg allergy 10.1 HCN4 LMNA SCN5A
29 autoimmune disease of skin and connective tissue 10.1 LMNA MYH6 SCN5A
30 ventricular tachycardia, catecholaminergic polymorphic, 1 10.1 LMNA SCN5A
31 amyloidosis 10.1
32 lymphoma 10.0
33 joint disorders 10.0 AGT F2
34 brugada syndrome 10.0
35 cardiomyopathy 10.0
36 rectum neuroendocrine neoplasm 9.9 F2 TGFB1
37 hyperphosphatemia 9.9 HCN4 RANGRF SCN5A
38 atrophic vulva 9.9 F2 TGFB1
39 heart disease 9.9
40 dextrocardia 9.9
41 joubert syndrome 13 9.9 MYH6 SHOX2
42 levocardia 9.8
43 polymyositis 9.8
44 hyperthyroidism 9.8
45 myocardial infarction 9.8
46 pericarditis 9.8
47 artery disease 9.8
48 myotonic dystrophy 9.8
49 potato nose 9.8 AGT TGFB1
50 benign partial epilepsy of infancy with complex partial seizures 9.8 AGT HCN4 MYH6 SCN5A

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to Sick Sinus Syndrome

Symptoms & Phenotypes for Sick Sinus Syndrome

MGI Mouse Phenotypes related to Sick Sinus Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 AGT F2 HCN4 LMNA MYH6 SCN5A
2 behavior/neurological MP:0005386 9.91 AGT F2 LMNA MYH6 SCN5A SGO1
3 mortality/aging MP:0010768 9.81 AGT F2 HCN4 LMNA MYH6 SCN5A
4 digestive/alimentary MP:0005381 9.65 F2 LMNA SGO1 SHOX2 TGFB1
5 muscle MP:0005369 9.43 TGFB1 AGT HCN4 LMNA MYH6 SCN5A
6 nervous system MP:0003631 9.17 AGT F2 HCN4 LMNA SCN5A SHOX2

Drugs & Therapeutics for Sick Sinus Syndrome

Drugs for Sick Sinus Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
2
Propafenone Approved Phase 4 54063-53-5 4932
3
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
4
Ethanol Approved Phase 4 64-17-5 702
5 Adrenergic Agents Phase 4
6 Adrenergic Antagonists Phase 4
7 Adrenergic beta-Antagonists Phase 4
8 Anti-Arrhythmia Agents Phase 4
9 Autonomic Agents Phase 4
10 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
12 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
13 Cytochrome P-450 CYP3A Inhibitors Phase 4
14 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
15 Diuretics, Potassium Sparing Phase 4
16 Neurotransmitter Agents Phase 4
17 Peripheral Nervous System Agents Phase 4
18 Potassium Channel Blockers Phase 4
19 Sodium Channel Blockers Phase 4
20 Sympatholytics Phase 4
21 Vasodilator Agents Phase 4
22
Bacitracin Approved, Vet_approved Phase 3 1405-87-4 439542 10909430
23
Cephalexin Approved, Vet_approved Phase 3 15686-71-2 27447
24
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
25
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
26
Ofloxacin Approved Phase 3 82419-36-1 4583
27 Anti-Bacterial Agents Phase 3
28 Antibiotics, Antitubercular Phase 3
29 Anti-Infective Agents Phase 3
30 Anti-Infective Agents, Local Phase 3
31 Antitubercular Agents Phase 3
32 Clindamycin palmitate Phase 3
33 Clindamycin phosphate Phase 3
34 Polymyxin B Phase 3
35 Polymyxins Phase 3
36 Renal Agents Phase 3
37 Topoisomerase Inhibitors Phase 3
38
Losartan Approved 114798-26-4 3961
39
Menthol Approved 2216-51-5 16666
40
Benzocaine Approved 1994-09-7, 94-09-7 2337
41 tannic acid Approved, Nutraceutical
42
Angiotensin II Investigational 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
43 Angiotensinogen
44 Angiotensin II Type 1 Receptor Blockers
45 Angiotensin Receptor Antagonists
46 Antihypertensive Agents

Interventional clinical trials:

(show top 50) (show all 59)

id Name Status NCT ID Phase Drugs
1 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
2 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation Unknown status NCT00224341 Phase 4
3 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
4 Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation Unknown status NCT02145546 Phase 4 Amiodarone;Propafenone;Sotalol
5 Pacing of the Atria in Sick Sinus Syndrome Trial Preventive Strategies for Atrial Fibrillation Completed NCT00161538 Phase 4
6 Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing Completed NCT00286858 Phase 4
7 Austria Study - Analysis of Difference Between Active and Passive Fixation Leads Completed NCT00180557 Phase 4
8 Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease Completed NCT01170611 Phase 4
9 Medtronic Genetic Arrhythmia Markers for Early Detection (GAME Study) Completed NCT00664807 Phase 4
10 DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed NCT00478933 Phase 4
11 Falls and Cardiovascular Events in Pacemaker Patients Completed NCT01037426 Phase 4
12 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
13 Syncope: Pacing or Recording in the Later Years Active, not recruiting NCT01423994 Phase 4
14 Virtual Clinic Pacemaker Follow-up Terminated NCT00475124 Phase 4
15 Increasing Atrial Base Rate Pacing to Reduce Atrial Fibrillation Completed NCT02317068 Phase 3
16 Mode Selection Trial in Sinus Node Dysfunction (MOST) Completed NCT00000561 Phase 3
17 Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. Recruiting NCT02809131 Phase 3 polymixin/bacitracin;cephalexin, or levofloxacin, or clindamycin;Saline
18 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
19 Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular Septum Completed NCT01609738 Phase 1, Phase 2
20 Second Study on Cardio-neuromodulation in Humans Recruiting NCT02954666 Phase 2
21 RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome Unknown status NCT01477138
22 The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome Unknown status NCT01310920
23 The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome Unknown status NCT00647257 Losartan;Placebo
24 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
25 Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI) Unknown status NCT00785564
26 Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study Unknown status NCT02314897
27 Identification of Gene Polymorphism in Patients With Sick Sinus Syndrome in Chinese Population in Taiwan Unknown status NCT00314223
28 Right Ventricular Lead Placement in a Pacemaker Population: Evaluation of Apical and Alternative Position Unknown status NCT01647490
29 A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction Unknown status NCT02027909
30 Minimizing Ventricular Pacing Unknown status NCT01611389
31 Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode Unknown status NCT02586480
32 The Impact of Heart Rate on Central Blood Pressure in Sick Sinus Syndrome Patients With a Permanent Cardiac Pacemaker Completed NCT03245996
33 Ventricular Pace Suppression Versus Intrinsic Rhythm Support Study Completed NCT01528657
34 Right Ventricle (RV) Markers of Future Pacing Induced Ventricular Dysfunction - Pilot Completed NCT02198781
35 The Atrial High Rate Episodes in Pacemaker Patients Completed NCT00627328
36 Prospective Registry of Pacemaker Patients Concerning Percentage of Right Ventricular Pacing, LVEF and NYHA Class Completed NCT00292539
37 SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction Completed NCT00284830
38 Natural Evolution of AV Conduction Disorders in Patients Implanted With Cardiac Pacemakers Completed NCT00531037
39 To Pace or Not to Pace in Sinus Node Disease Completed NCT02485093
40 Right Ventricular Outflow Tract Study Completed NCT01294839
41 Evaluation of Pacemaker Algorithms to Avoid Unnecessary Right Ventricular Pacing Completed NCT01803217
42 Ingenio Device Algorithm Study Completed NCT01441583
43 IES-ACap: Influence of Atrial Pulse Width in the Behaviour of ACap™ Confirm Algorithm. Completed NCT00832260
44 PANORAMA Observational Study Completed NCT00382525
45 Real Life Automatic Atrial Capture Device Control Completed NCT02400983
46 Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome. Recruiting NCT02034526
47 Left Ventricular Pacing to Avoid Cardiac Enlargement Study Recruiting NCT01302717
48 Registry to Improve the Adoption of Consensus Treatment Guidelines (IMPROVE Brady) Recruiting NCT01643707
49 AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR Intervals Recruiting NCT02154750
50 Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation Recruiting NCT03118440

Search NIH Clinical Center for Sick Sinus Syndrome

Cochrane evidence based reviews: sick sinus syndrome

Genetic Tests for Sick Sinus Syndrome

Genetic tests related to Sick Sinus Syndrome:

id Genetic test Affiliating Genes
1 Sinus Node Disease 29
2 Sick Sinus Syndrome 29

Anatomical Context for Sick Sinus Syndrome

MalaCards organs/tissues related to Sick Sinus Syndrome:

39
Heart, Testes, Brain, Atrioventricular Node, Lung, B Cells, Spleen

Publications for Sick Sinus Syndrome

Articles related to Sick Sinus Syndrome:

(show top 50) (show all 543)
id Title Authors Year
1
Clinical phenotype of HCN4-related sick sinus syndrome. ( 28213054 )
2017
2
An unexpected presentation of sick sinus syndrome: Isolated ventricular asystole. ( 28460803 )
2017
3
Persistent Sick Sinus Syndrome in Scrub Typhus. ( 28500798 )
2017
4
Short-term heart rate variability in dogs with sick sinus syndrome or chronic mitral valve disease as compared to healthy controls. ( 28525326 )
2017
5
Congenital sick sinus syndrome: Prenatal diagnosis and postnatal follow-up. ( 28805625 )
2017
6
Isolated Persistent Left Superior Vena Cava, Sick Sinus Syndrome, and Challenging Pacemaker Implantation. ( 28912977 )
2017
7
Value of Combining Left Atrial Diameter and Amino-terminal Pro-brain Natriuretic Peptide to the CHA2DS2-VASc Score for Predicting Stroke and Death in Patients with Sick Sinus Syndrome after Pacemaker Implantation. ( 28776540 )
2017
8
Eleven-year trends of inpatient pacemaker implantation in patients diagnosed with sick sinus syndrome. ( 28471545 )
2017
9
Long term effects of cilostazol in a dog with sick sinus syndrome. ( 28458273 )
2017
10
Hyperthyroidism and sick sinus syndrome, a rare but challenging association: A study of three cases. ( 28891553 )
2017
11
Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. ( 28674041 )
2017
12
Sick sinus syndrome with HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular noncompaction. ( 28104484 )
2017
13
Implantation of VVI pacemaker in a patient with dextrocardia, persistent left superior vena cava, and sick sinus syndrome: A case report. ( 28151908 )
2017
14
Sick sinus syndrome. ( 28644224 )
2017
15
A Functional Assay for Sick Sinus Syndrome Genetic Variants. ( 28803248 )
2017
16
Autosomal recessive atrial disease presenting with sick sinus syndrome (SSS), right atrial fibrosis and biatrial dilatation: Clinical impact of genetic diagnosis. ( 26828384 )
2016
17
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block. ( 26831068 )
2016
18
Single lead atrial vs. dual chamber pacing in sick sinus syndrome: extended register-based follow-up in the DANPACE trial. ( 28039212 )
2016
19
Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome. ( 26798387 )
2016
20
Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002-2014). ( 27286907 )
2016
21
Transforming Growth Factor-I^1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein Level. ( 27380173 )
2016
22
SEVERE AMIODARONE-INDUCED BRADICARDIA CONCEALES SICK SINUS SYNDROME: CASE REPORT. ( 27125081 )
2016
23
Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. ( 27182706 )
2016
24
Beneficial effects of losartan for prevention of paroxysmal atrial fibrillation in patients with sick sinus syndrome: analysis with memory function of pacemaker. ( 25787020 )
2015
25
Elevated plasma norepinephrine level and sick sinus syndrome in patients with lone atrial fibrillation. ( 25968056 )
2015
26
Beware of Venous Anomalies in Young Patients with Sick Sinus Syndrome: A Report of Two Cases of Sick Sinus Syndrome with Systemic Venous Anomalies. ( 27326354 )
2015
27
Predictors of sick sinus syndrome in patients after successful radiofrequency catheter ablation of atrial flutter. ( 25510744 )
2015
28
Sodium Hydroxide Pinpoint Pressing Permeation Method for the Animal Modeling of Sick Sinus Syndrome. ( 26118592 )
2015
29
Stored intracardiac electrograms reveal patients with sick sinus syndrome frequently develop atrioventricular block. ( 25947003 )
2015
30
Anaplastic lymphoma kinase-positive lung adenocarcinoma patient with development of sick sinus syndrome while on targeted treatment with crizotinib. ( 25922742 )
2015
31
Red blood cell distribution width and atrial fibrillation in patients with sick sinus syndrome. ( 26321105 )
2015
32
Role of temporary pacing at the right ventricular outflow tract in anesthetic management of a patient with asymptomatic sick sinus syndrome. ( 26712989 )
2015
33
Sick sinus syndrome and atrial fibrillation in older persons - A view from the sinoatrial nodal myocyte. ( 25668431 )
2015
34
Novel Mutation in the I+-Myosin Heavy Chain Gene Is Associated With Sick Sinus Syndrome. ( 25717017 )
2015
35
Development of Atrioventricular Block and Diagnostic Value of Stored Electrograms in Patients With Sick Sinus Syndrome and Implanted Pacemaker. ( 25753690 )
2015
36
Sick Sinus Syndrome. ( 26485000 )
2015
37
ECG of the Month. Third-degree AV block with sick sinus syndrome. ( 25835165 )
2015
38
Dual-chamber pacemakers for treating symptomatic bradycardia due to sick sinus syndrome without atrioventricular block: a systematic review and economic evaluation. ( 26293406 )
2015
39
Combined Algorithm Using a Poor Increase in Inferior P-Wave Amplitude During Sympathetic Stimulation and Sinus Node Recovery Time for the Diagnosis of Sick Sinus Syndrome. ( 26289967 )
2015
40
Effective Management of Atrioventricular Interval for Paroxysmal Atrial Fibrillation That Developed After DDDR Pacemaker Implantation in a Sick Sinus Syndrome Patient. ( 26370366 )
2015
41
Donepezil-associated sick sinus syndrome. ( 24515686 )
2014
42
Sick sinus syndrome associated with hypopituitarism: a case report and literature review. ( 25332716 )
2014
43
Sick sinus syndrome: synopsis. ( 25104520 )
2014
44
A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation. ( 24582607 )
2014
45
Isoprenaline: a potential contributor in sick sinus syndrome--insights from a mathematical model of the rabbit sinoatrial node. ( 24578642 )
2014
46
Right versus left atrial pacing in patients with sick sinus syndrome and paroxysmal atrial fibrillation (Riverleft study): study protocol for randomized controlled trial. ( 25403703 )
2014
47
The effectiveness of the atrial or atrio-ventricular stimulation for sick sinus syndrome in a long term observation. ( 25001847 )
2014
48
Genetic analysis in a family affected by sick sinus syndrome may reduce the sudden death risk in a young aspiring competitive athlete. ( 24295898 )
2014
49
Association of sick sinus syndrome with incident cardiovascular disease and mortality: the atherosclerosis risk in communities study and cardiovascular health study. ( 25285853 )
2014
50
Syncope in paced patients with sick sinus syndrome from the DANPACE trial: incidence, predictors and prognostic implication. ( 24711481 )
2014

Variations for Sick Sinus Syndrome

ClinVar genetic disease variations for Sick Sinus Syndrome:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.5350G> A (p.Glu1784Lys) single nucleotide variant Pathogenic rs137854601 GRCh37 Chromosome 3, 38592513: 38592513
2 SCN5A NM_198056.2(SCN5A): c.3308C> A (p.Ser1103Tyr) single nucleotide variant risk factor rs7626962 GRCh37 Chromosome 3, 38620907: 38620907
3 SCN5A NM_000335.4(SCN5A): c.3890C> T (p.Pro1297Leu) single nucleotide variant Pathogenic rs28937319 GRCh37 Chromosome 3, 38603976: 38603976

Expression for Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for Sick Sinus Syndrome

Pathways related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.45 AGT LMNA TGFB1
2 10.88 HCN4 LMNA SCN5A
3 10.52 MYH6 SCN5A TGFB1

GO Terms for Sick Sinus Syndrome

Cellular components related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intercalated disc GO:0014704 8.96 RANGRF SCN5A
2 blood microparticle GO:0072562 8.8 AGT F2 TGFB1

Biological processes related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of fibroblast proliferation GO:0048146 9.58 AGT TGFB1
2 regulation of postsynaptic membrane potential GO:0060078 9.58 HCN4 SCN5A
3 cardiac muscle contraction GO:0060048 9.57 MYH6 SCN5A
4 chondrocyte differentiation GO:0002062 9.56 SHOX2 TGFB1
5 regulation of heart rate by cardiac conduction GO:0086091 9.55 HCN4 SCN5A
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.54 AGT F2
7 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.52 MYH6 TGFB1
8 positive regulation of protein localization to nucleus GO:1900182 9.51 F2 TGFB1
9 positive regulation of collagen biosynthetic process GO:0032967 9.49 F2 TGFB1
10 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.48 AGT TGFB1
11 positive regulation of cellular protein metabolic process GO:0032270 9.46 AGT TGFB1
12 positive regulation of superoxide anion generation GO:0032930 9.43 AGT TGFB1
13 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.4 HCN4 SCN5A
14 regulation of sodium ion transmembrane transport GO:1902305 9.37 RANGRF SCN5A
15 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 9.32 HCN4 RANGRF
16 regulation of membrane depolarization GO:0003254 9.26 HCN4 RANGRF
17 SA node cell action potential GO:0086015 9.16 HCN4 SCN5A
18 regulation of heart rate GO:0002027 9.02 AGT HCN4 MYH6 RANGRF SCN5A
19 membrane depolarization during SA node cell action potential GO:0086046 8.96 HCN4 SCN5A

Molecular functions related to Sick Sinus Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sodium channel activity GO:0005272 9.16 HCN4 SCN5A
2 voltage-gated sodium channel activity GO:0005248 8.96 HCN4 SCN5A
3 growth factor activity GO:0008083 8.8 AGT F2 TGFB1

Sources for Sick Sinus Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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