SND
MCID: SCK002
MIFTS: 52

Sick Sinus Syndrome (SND) malady

Cardiovascular diseases category

Summaries for Sick Sinus Syndrome

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21Genetics Home Reference, 63Wikipedia, 32MalaCards
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Genetics Home Reference:21 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards: Sick Sinus Syndrome, also known as sinus node dysfunction, is related to atrioventricular block and brugada syndrome. An important gene associated with Sick Sinus Syndrome is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Cardiomyocyte Differentiation through BMP Receptors. The compounds isoproterenol and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related mouse phenotypes are muscle and cardiovascular system.

Wikipedia:63 Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of... more...

Aliases & Classifications for Sick Sinus Syndrome

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8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

sick sinus syndrome 8 21 10 44 60
sinus node dysfunction 21 60
sinus node disease 21
snd 21
sss 21


External Ids:

Disease Ontology8 DOID:13884
NCIt39 C62244
MeSH34 D012804
ICD1025 I49.5

Related Diseases for Sick Sinus Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Sick Sinus Syndrome 2 family:

sick sinus syndrome Sick Sinus Syndrome 1
Sick Sinus Syndrome 3

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1atrioventricular block30.9SCN5A, NPPB
2brugada syndrome30.7SCN5A, HCN4
3sick sinus syndrome 230.6HCN4
4myocardial infarction30.3NPPB, NPPA, AGT
5hypertrophic cardiomyopathy30.1MYH6
6atrial heart septal defect30.1NPPB, MYH6
7stroke, ischemic30.1NPPA, F2
8arrhythmogenic right ventricular dysplasia30.1SCN5A
9acute myocardial infarction30.1NPPB, AGT, NPPA
10coronary artery disease30.1AGT, NPPB, NPPA, SCN5A
11diabetes mellitus30.1NPPA, NPPB, CYP27B1, AGT
12amyloidosis10.5
13adult syndrome10.5
14sick sinus syndrome 110.5
15sick sinus syndrome 310.4
16sinus node disease and myopia10.4
17thyrotoxicosis10.3
18image syndrome10.3
19sick sinus syndrome 2, autosomal dominant10.3
20sick sinus syndrome 1, autosomal recessive10.3
21parkinson's disease10.3
22heart lymphoma10.3
23dextrocardia10.3
24myotonic dystrophy10.3
25pericarditis10.3
26erdheim-chester disease10.1
27systemic lupus erythematosus10.1
28lupus erythematosus10.1
29catecholaminergic polymorphic ventricular tachycardia10.1
30arteriovenous fistula10.1
31ebstein anomaly10.1
32congenital heart block10.1
33non-hodgkin lymphoma10.1
34cerebritis10.1
35ritter's disease10.1
36west syndrome10.1
37hemochromatosis10.1
38conduct disorder10.1
39acromegaly10.1
40alzheimer's disease10.1
41situs inversus10.1
42infertility10.1
43inferior myocardial infarction10.1
44typhoid fever10.1
45glossopharyngeal neuralgia10.1
46down syndrome10.1
47cataract10.1
48cervicitis10.1
49encephalitis10.1
50epilepsy syndrome10.1

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to sick sinus syndrome

Clinical Features for Sick Sinus Syndrome

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Drugs & Therapeutics for Sick Sinus Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sick Sinus Syndrome

Drug clinical trials:

Search ClinicalTrials for Sick Sinus Syndrome

Search NIH Clinical Center for Sick Sinus Syndrome

Search CenterWatch for Sick Sinus Syndrome

Genetic Tests for Sick Sinus Syndrome

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Anatomical Context for Sick Sinus Syndrome

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32MalaCards
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MalaCards organs/tissues related to Sick Sinus Syndrome:

32
Heart, Testes, Atrioventricular node, Spleen, Brain, B cells, Endothelial

Animal Models for Sick Sinus Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Sick Sinus Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7NPPA, SCN5A, AGT, MYH6, HCN4, NPPB
2MP:00053855.6RGS6, NPPB, NPPA, SCN5A, AGT, PODXL

Publications for Sick Sinus Syndrome

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50PubMed
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Articles related to Sick Sinus Syndrome:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
A novel SCN5A mutation demonstrating a variety of clinical phenotypes in familial sick sinus syndrome. (23955615)
2013
2
Successful treatment of sick sinus syndrome with Traditional Chinese Medicine. (22622592)
2012
3
Heart failure in patients with sick sinus syndrome treated with single lead atrial or dual-chamber pacing: no association with pacing mode or right ventricular pacing site. (22447958)
2012
4
A case of sick sinus syndrome and autonomic failure with Parkinson's disease. (19179119)
2009
5
Primary cardiac lymphoma presenting as sick sinus syndrome. (19029409)
2008
6
Recurrent syncope due to carotid sinus hypersensitivity and sick sinus syndrome. (18955189)
2008
7
Implantation of pacemaker for sick sinus syndrome in a patient with persistent left superior vena cava and absent right superior vena cava. (18484165)
2008
8
Role of the low amplitude potential in the initial P wave signal-averaged electrocardiogram [corrected] in sick sinus syndrome. (16864929)
2006
9
Azygos continuation of interrupted inferior vena cava in association with sick sinus syndrome. (15772175)
2005
10
Death in patients with permanent pacemakers for sick sinus syndrome. (14597940)
2003
11
Acromegaly with multiple cardiovascular complications--cardiomyopathy, chordae rupture of mitral valve, myocardial infarction and sick sinus syndrome. (12924495)
2003
12
Implantation of a dual-chamber, rate-adaptive pacemaker in a horse with suspected sick sinus syndrome. (12448492)
2002
13
A case of sick sinus syndrome presenting for emergency surgery. (11789471)
2001
14
Screw-in atrial lead in a sick sinus syndrome patient with anomalous inferior vena cava. (11804306)
2001
15
Regional myocardial blood flow in patients with sick sinus syndrome randomized to long-term single chamber atrial or dual chamber pacing--effect of pacing mode and rate. (10807447)
2000
16
Prolonged atrioventricular block during AAI pacing for sick sinus syndrome. (11196569)
2000
17
Sick sinus syndrome with and without atrial fibrillation: atrial refractoriness and conduction characteristics. (10371788)
1999
18
Implications of marked fatty infiltration around and in the atrophic atrioventricular node in elderly patients with permanent pacemaker implantation for symptomatic sick sinus syndrome. (10943612)
1999
19
AAI pacing for sick sinus syndrome: first choice on all counts. (9875100)
1998
20
Long-term single-chamber atrial pacing for sick-sinus syndrome was associated with fewer deaths and adverse events. (16379808)
1998
21
Atrioventricular conduction during long-term follow-up of patients with sick sinus syndrome. (9751681)
1998
22
Rate adaptive pacing in sick sinus syndrome: effects of pacing modes and intrinsic conduction on physiological responses, arrhythmias, symptomatology and quality of life. (7835358)
1994
23
Supernormal atrial conduction and its relation to atrial vulnerability and atrial fibrillation in patients with sick sinus syndrome and paroxysmal atrial fibrillation. (7517097)
1994
24
The effect of exogenous adenosine in patients with neurally-mediated syncope and sick sinus syndrome. (7845845)
1994
25
Familial sick sinus syndrome in two siblings. (8236519)
1993
26
Sick sinus syndrome and diffuse impairment of the conduction system in a child: successful pacing with a steroid eluting endocardial pacing lead. (1736268)
1992
27
Pacing for carotid sinus syndrome and sick sinus syndrome. (1704595)
1990
28
Survival rates after pacemaker implantation: a study of patients paced for sick sinus syndrome and atrioventricular block. (2476742)
1989
29
Reappraisal of atrioventricular junctional pacemaker automaticity in the sick sinus syndrome. Clinical significance and the role of autonomic chronotropic influences. (3371095)
1988
30
Benefits of dual chamber pacing in sick sinus syndrome. (3056477)
1988
31
Exercise testing in the diagnosis of sick sinus syndrome in the elderly: implications for treatment. (2441368)
1987
32
Syncope in the elderly. Report of 3 cases with sick sinus syndrome. (3704847)
1986
33
Sick sinus syndrome and adenosine. (2860533)
1985
34
Pericarditis and the sick sinus syndrome. (4037959)
1985
35
Current concepts and management of the sick sinus syndrome. (6567640)
1984
36
Comparative evaluation of depressed automaticity in sick sinus syndrome by Holter monitoring and overdrive suppression test. (6682281)
1983
37
Persistent sinus nodal electrograms during abnormally prolonged postpacing atrial pauses in sick sinus syndrome in humans: sinoatrial block vs overdrive suppression. (6851052)
1983
38
Experience with permanent pacing in the sick sinus syndrome. (6357444)
1983
39
A clinicopathologic study on sick sinus syndrome with histological approach to the sinoatrial node. (7401276)
1980
40
The importance of sick sinus syndrome in insurance medicine. (7331182)
1980
41
Sick sinus syndrome. (7309049)
1980
42
Survival in sinoatrial disorder (sick-sinus syndrome). (7357290)
1980
43
Diagnosis and treatment of sick sinus syndrome. (6772398)
1980
44
Sick sinus syndrome and AV node re-entry. (95297)
1979
45
Obscure syncope and the sick sinus syndrome. (83623)
1978
46
Junctional escape rhythm in the sick sinus syndrome. (657171)
1978
47
The sick sinus syndrome. (619525)
1978
48
Clinical spectrum of the sick sinus syndrome. (836172)
1977
49
Sick sinus syndrome in children. (1259455)
1976
50
Sick sinus syndrome requiring permanent pacemaker implantation in a patient with mirror-image dextrocardia. (1261330)
1976

Genetic Variations for Sick Sinus Syndrome

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Expression for genes affiliated with Sick Sinus Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for genes affiliated with Sick Sinus Syndrome

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 53Reactome, 49PharmGKB, 12EMD Millipore
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Compounds for genes affiliated with Sick Sinus Syndrome

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1isoproterenol44 1111.6MYH6
2norepinephrine44 11 2412.5MYH6
3p000354410.2NPPB, NPPA
4hncs4410.2NPPB, NPPA
5ly 835834410.2NPPA, AGT
6alacepril4410.2NPPA, NPPB
7candoxatril44 1111.2NPPA, NPPB
8imidapril4410.2NPPA, NPPB
9benazepril44 1111.2AGT, NPPA
10urodilatin4410.2NPPA, NPPB
11trandolapril44 1111.1NPPB, NPPA
12inulin4410.1AGT, NPPA
13bisoprolol44 49 1112.1NPPA, NPPB
14hanp4410.1NPPB, NPPA
15dobutamine44 28 1112.1NPPB, NPPA
16fosinopril44 1111.1NPPB, NPPA
17moxonidine4410.1NPPB, NPPA
18hydroxyethyl starch4410.0NPPA, F2
19enalaprilat449.9NPPB, AGT, NPPA
20lisinopril44 11 2411.9NPPA, NPPB, AGT
218-bromo cgmp449.9AGT, NPPA, NPPB
22perindopril44 49 1111.9NPPB, NPPA, AGT
23enalapril44 49 1111.9NPPB, AGT, NPPA
24amlodipine44 49 11 2412.9NPPB, NPPA, AGT
25ang ii449.9AGT, NPPA, NPPB
26l-nmma449.9NPPA, NPPB, AGT
27phenylephrine44 28 11 2412.8NPPA, NPPB, AGT
28losartan44 49 28 1112.8NPPB, AGT, NPPA
29metoprolol44 28 49 11 2413.8NPPA, NPPB
30digoxin44 49 59 11 2413.8F2, NPPA, NPPB
31haloperidol44 28 2 49 1113.8AGT, NPPB, NPPA
32nppb44 59 2811.7NPPA, NPPB
33aprotinin44 1110.7AGT, NPPB, F2
34guanylate449.6NPPB, NPPA, AGT
35forskolin44 49 1111.6AGT, NPPA, NPPB
36homocysteine44 2410.5NPPB, F2, AGT
37mibg449.5NPPB, NPPA
38potassium44 11 2411.5HCN4, HCN2, NPPA, SCN5A, AGT
39epinephrine44 11 2411.4NPPA, NPPB, AGT, F2
40estradiol44 11 2411.4AGT, MYH6, NPPB, CYP27B1
41ivabradine289.3HCN1, HCN2, HCN4, HCN3
42zd7288289.3HCN1, HCN2, HCN4, HCN3
43zatebradine289.3HCN1, HCN3, HCN2, HCN4
44cilobradine289.3HCN2, HCN3, HCN1, HCN4
45cs+289.3HCN3, HCN2, HCN4, HCN1
46arginine449.2AGT, SCN5A, NPPA, NPPB, MYH6
47pge2449.2CYP27B1, AGT, NPPB, NPPA
48cyclosporin a44 28 5911.1NPPA, AGT, NPPB, F2
49cyclic amp44 249.7HCN3, CYP27B1, NPPA, HCN2, HCN4, HCN1
50sodium44 249.0AGT, HCN3, HCN1, HCN4, NPPB, HCN2

GO Terms for genes affiliated with Sick Sinus Syndrome

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16Gene Ontology
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Cellular components related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.1RGS6, F2, HCN3, HCN1, HCN4, HCN2

Biological processes related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0NPPA, NPPB
2receptor guanylyl cyclase signaling pathwayGO:00716810.0NPPA, NPPB
3regulation of heart contractionGO:00801610.0HCN4, MYH6
4cation transportGO:0068129.9HCN4, HCN2
5regulation of blood vessel sizeGO:0508809.9NPPA, NPPB
6positive regulation of renal sodium excretionGO:0358159.9AGT, NPPB
7muscle contractionGO:0069369.9MYH6, HCN2, HCN4
8regulation of heart rateGO:0020279.9SCN5A, MYH6
9regulation of blood pressureGO:0082179.8MYH6, NPPA, NPPB
10positive regulation of reactive oxygen species metabolic processGO:20003799.4F2, AGT
11negative regulation of cell growthGO:0303089.4NPPB, NPPA, AGT, CYP27B1
12potassium ion transmembrane transportGO:0718059.1HCN3, HCN1, HCN4, HCN2
13regulation of membrane potentialGO:0423919.1HCN2, HCN4, HCN1, HCN3
14synaptic transmissionGO:0072688.9HCN2, HCN4, HCN1, HCN3

Molecular functions related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cation channel activityGO:0052619.9HCN4, HCN2
2hormone activityGO:0051799.2AGT, NPPA, NPPB
3sodium channel activityGO:0052728.9HCN3, HCN1, HCN4, HCN2
4cAMP bindingGO:0305528.9HCN2, HCN4, HCN1, HCN3
5voltage-gated potassium channel activityGO:0052498.8HCN2, HCN4, HCN1, HCN3

Products for genes affiliated with Sick Sinus Syndrome

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Sources for Sick Sinus Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet