SND
MCID: SCK002
MIFTS: 50

Sick Sinus Syndrome (SND) malady

Cardiovascular category

Summaries for Sick Sinus Syndrome

Sources:
21Genetics Home Reference, 64Wikipedia, 33MalaCards
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Genetics Home Reference:21 Sick sinus syndrome (also known as sinus node dysfunction) is a group of related heart conditions that can affect how the heart beats. "Sick sinus" refers to the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The SA node generates electrical impulses that start each heartbeat. These signals travel from the SA node to the rest of the heart, signaling the heart (cardiac) muscle to contract and pump blood. In people with sick sinus syndrome, the SA node does not function normally. In some cases, it does not produce the right signals to trigger a regular heartbeat. In others, abnormalities disrupt the electrical impulses and prevent them from reaching the rest of the heart.

MalaCards: Sick Sinus Syndrome, also known as sinus node dysfunction, is related to atrioventricular block and brugada syndrome. An important gene associated with Sick Sinus Syndrome is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and Cardiomyocyte Differentiation through BMP Receptors. The compounds isoproterenol and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, spleen and heart, and related mouse phenotypes are muscle and cardiovascular system.

Wikipedia:64 Sick sinus syndrome (SSS), also called sinus node dysfunction (SND), is an umbrella term for a group of... more...

Aliases & Classifications for Sick Sinus Syndrome

Sources:
8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

sick sinus syndrome 8 21 10 45 61
sinus node dysfunction 21 61
sinus node disease 21
snd 21
sss 21


External Ids:

Disease Ontology8 DOID:13884
NCIt40 C62244
MeSH35 D012804
ICD1025 I49.5

Related Diseases for Sick Sinus Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the sick sinus syndrome 2 family:

sick sinus syndrome sick sinus syndrome 1
sick sinus syndrome 3

Diseases related to Sick Sinus Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1atrioventricular block30.9SCN5A, NPPB
2brugada syndrome30.8SCN5A, HCN4
3sick sinus syndrome 230.6HCN4
4thromboembolism30.4F2
5hypertrophic cardiomyopathy30.2MYH6
6atrial heart septal defect30.1NPPB, MYH6
7stroke, ischemic30.1NPPA, F2
8acute myocardial infarction30.1NPPB, AGT, NPPA
9coronary artery disease,30.1AGT, NPPB, NPPA, SCN5A
10n syndrome11.0
11syncope10.7
12amyloidosis10.5
13young syndrome10.5
14adult syndrome10.5
15sick sinus syndrome 110.5
16char syndrome10.4
17sick sinus syndrome 310.4
18sinus node disease and myopia10.4
19thyrotoxicosis10.4
20single ventricular heart10.4
21sick sinus syndrome 2, autosomal dominant10.4
22sick sinus syndrome 1, autosomal recessive10.4
23ebstein anomaly10.3
24parkinson's disease10.3
25heart lymphoma10.3
26dextrocardia10.3
27polymyositis10.3
28image syndrome10.3
29silent sinus syndrome10.3
30levocardia10.3
31erdheim-chester disease10.1
32systemic lupus erythematosus10.1
33catecholaminergic polymorphic ventricular tachycardia10.1
34limbic encephalitis10.1
35congenital heart block10.1
36klinefelter's syndrome10.1
37ritter's disease10.1
38west syndrome10.1
39hemochromatosis10.1
40conduct disorder10.1
41acromegaly10.1
42alzheimer's disease10.1
43situs inversus10.1
44infertility10.1
45inferior myocardial infarction10.1
46typhoid fever10.1
47fabry disease10.1
48glossopharyngeal neuralgia10.1
49micro syndrome10.1
50short syndrome10.1

Graphical network of the top 20 diseases related to Sick Sinus Syndrome:



Diseases related to sick sinus syndrome

Clinical Features for Sick Sinus Syndrome

Drugs & Therapeutics for Sick Sinus Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Sick Sinus Syndrome

Drug clinical trials:

Search ClinicalTrials for Sick Sinus Syndrome

Search NIH Clinical Center for Sick Sinus Syndrome

Search CenterWatch for Sick Sinus Syndrome

Genetic Tests for Sick Sinus Syndrome

Anatomical Context for Sick Sinus Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Sick Sinus Syndrome:

33
Brain, Spleen, Heart, B cells, Endothelial, Fetal brain, Atrioventricular node

Animal Models for Sick Sinus Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Sick Sinus Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7NPPA, SCN5A, AGT, MYH6, HCN4, NPPB
2MP:00053855.6RGS6, NPPB, NPPA, SCN5A, AGT, PODXL

Publications for Sick Sinus Syndrome

Sources:
51PubMed
See all sources

Articles related to Sick Sinus Syndrome:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Left atrial responses to acute right ventricular apical pacing in patients with sick sinus syndrome. (23822568)
2013
2
Sick sinus syndrome: a family study. (24020943)
2013
3
Arrhythmias: AF pacing in sick sinus syndrome. (23917465)
2013
4
Pacemaker implantation in a patient with brugada and sick sinus syndrome. (23538678)
2013
5
Heart failure in patients with sick sinus syndrome treated with single lead atrial or dual-chamber pacing: no association with pacing mode or right ventricular pacing site. (22447958)
2012
6
Congenital sick sinus syndrome with atrial inexcitability and coronary sinus flutter. (22010118)
2011
7
A rare variant in MYH6 is associated with high risk of sick sinus syndrome. (21378987)
2011
8
Insights into sick sinus syndrome from an inducible mouse model. (21193513)
2011
9
Spontaneously isolated sinus node activation in sick sinus syndrome as revealed by a three-dimensional mapping system. (19963441)
2010
10
Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome. (20539757)
2010
11
Ser49gly polymorphism as predictor of development of hereditary sick sinus node syndrome]. (19845516)
2009
12
The immediate effects of pacemaker-related electric remodelling on left ventricular function in patients with sick sinus syndrome. (19880851)
2009
13
DDD(R)-pacing, but not AAI(R)-pacing induces left ventricular desynchronization in patients with sick sinus syndrome: tissue-Doppler and 3D echocardiographic evaluation in a randomized controlled comparison. (18192700)
2008
14
A patient with sick sinus syndrome, atrial flutter and bidirectional ventricular tachycardia: Coincident or concomitant presentations? (18651526)
2007
15
ECG of the month. Sick sinus syndrome. (16013537)
2005
16
Atrial pacemaker complex preserved radiofrequency maze procedure reducing the incidence of sick sinus syndrome in patients with atrial fibrillation. (16236925)
2005
17
Diagnosis and treatment of sick sinus syndrome. (12725451)
2003
18
A case of generalized morphea and polymyositis accompanied by sick sinus syndrome. (11732729)
2001
19
Prolonged atrioventricular block during AAI pacing for sick sinus syndrome. (11196569)
2000
20
Relationship between atrioventricular delay and oxygen consumption in patients with sick sinus syndrome: relevance to rate responsive pacing. (10456634)
1999
21
Transient sick sinus syndrome associated with immunoblastic lymphadenopathy. (9249614)
1997
22
An unusual association: sick sinus syndrome and congenital cataract in a 6-month-old girl. (8877431)
1996
23
Sick sinus syndrome--a rare complication of typhoid fever. (7883357)
1994
24
Sick sinus syndrome in a teenager treated with idarubicin. (8431564)
1993
25
Atrial pacing for sick sinus syndrome. (2404646)
1990
26
Cough syncope caused by sinus arrest in a patient with sick sinus syndrome. (2472614)
1989
27
Hyperkalemia-induced sick sinus syndrome. (3681174)
1987
28
Sinus node electrogram studies in patients with sick sinus syndrome. (3127128)
1987
29
The effects of cycle length on the fragmented atrial activity zone in patients with sick sinus syndrome. (3430105)
1987
30
Exercise testing in the diagnosis of sick sinus syndrome in the elderly: implications for treatment. (2441368)
1987
31
Current concepts in sick sinus syndrome. II. ECG manifestation and diagnostic and therapeutic approaches. (3985733)
1985
32
Sick sinus syndrome: an adenosine-mediated disease. (2858669)
1985
33
Pericarditis and the sick sinus syndrome. (4037959)
1985
34
Sinus node function after autonomic blockade in normals and in sick sinus syndrome. (6746124)
1984
35
Sick sinus syndrome. (6733350)
1984
36
Symptomatic sick sinus syndrome in children and adolescents as the only manifestation of cardiac abnormality or associated with unoperated congenital heart disease. (6837459)
1983
37
Experience with permanent pacing in the sick sinus syndrome. (6357444)
1983
38
Sick sinus syndrome: mechanisms and management. (7002307)
1980
39
Sick sinus syndrome. (400510)
1979
40
Sick sinus syndrome clinical features, diagnosis, and treatment. (383390)
1979
41
A study of atrioventricular nodal function in patients with the sick sinus syndrome. (513262)
1979
42
Electrophysiologic manifestations in so-called "sick sinus syndrome". (642192)
1978
43
Studies on the mechanism of sinus node dysfunction in the sick sinus syndrome. (618607)
1978
44
Partial atrial standstill in sick sinus syndrome; intraatrial and AV nodal block with short PR interval. (729599)
1978
45
Sick sinus syndrome. (1047966)
1976
46
First-degree sinoatrial heart block: sinoatrial block in the sick-sinus syndrome. (1258728)
1976
47
Clinical studies on the sick sinus syndrome. (1271572)
1976
48
Sick sinus syndrome. (18747709)
1976
49
"Paradoxical" prolongation of sinus nodal recovery time after atropine in the sick sinus syndrome. (1146702)
1975
50
Appraisal of sinus nodal recovery time in patients with sick sinus syndrome. (4850629)
1974

Genetic Variations for Sick Sinus Syndrome

Expression for genes affiliated with Sick Sinus Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sick Sinus Syndrome

Search GEO for disease gene expression data for Sick Sinus Syndrome.

Pathways for genes affiliated with Sick Sinus Syndrome

Sources:
38NCBI BioSystems Database, 52QIAGEN, 54Reactome, 50PharmGKB, 12EMD Millipore
See all sources

Compounds for genes affiliated with Sick Sinus Syndrome

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1isoproterenol45 1111.6MYH6
2norepinephrine45 11 2412.5MYH6
3p000354510.2NPPB, NPPA
4hncs4510.2NPPB, NPPA
5ly 835834510.2NPPA, AGT
6alacepril4510.2NPPA, NPPB
7candoxatril45 1111.2NPPA, NPPB
8imidapril4510.2NPPA, NPPB
9benazepril45 1111.2AGT, NPPA
10urodilatin4510.2NPPA, NPPB
11trandolapril45 1111.1NPPB, NPPA
12inulin4510.1AGT, NPPA
13bisoprolol45 50 1112.1NPPA, NPPB
14hanp4510.1NPPB, NPPA
15dobutamine45 29 1112.1NPPB, NPPA
16fosinopril45 1111.1NPPB, NPPA
17moxonidine4510.1NPPB, NPPA
18hydroxyethyl starch4510.0NPPA, F2
19enalaprilat459.9NPPB, AGT, NPPA
20lisinopril45 11 2411.9NPPA, NPPB, AGT
218-bromo cgmp459.9AGT, NPPA, NPPB
22perindopril45 50 1111.9NPPB, NPPA, AGT
23enalapril45 50 1111.9NPPB, AGT, NPPA
24amlodipine45 50 11 2412.9NPPB, NPPA, AGT
25ang ii459.9AGT, NPPA, NPPB
26l-nmma459.9NPPA, NPPB, AGT
27phenylephrine45 29 11 2412.8NPPA, NPPB, AGT
28losartan45 50 29 1112.8NPPB, AGT, NPPA
29metoprolol45 29 50 11 2413.8NPPA, NPPB
30digoxin45 50 60 11 2413.8F2, NPPA, NPPB
31haloperidol45 29 2 50 1113.8AGT, NPPB, NPPA
32nppb45 60 2911.7NPPA, NPPB
33aprotinin45 1110.7AGT, NPPB, F2
34guanylate459.6NPPB, NPPA, AGT
35forskolin45 50 1111.6AGT, NPPA, NPPB
36homocysteine45 2410.5NPPB, F2, AGT
37mibg459.5NPPB, NPPA
38potassium45 11 2411.5HCN4, HCN2, NPPA, SCN5A, AGT
39epinephrine45 11 2411.4NPPA, NPPB, AGT, F2
40estradiol45 11 2411.4AGT, MYH6, NPPB, CYP27B1
41ivabradine299.3HCN1, HCN2, HCN4, HCN3
42zd7288299.3HCN1, HCN2, HCN4, HCN3
43zatebradine299.3HCN1, HCN3, HCN2, HCN4
44cilobradine299.3HCN2, HCN3, HCN1, HCN4
45cs+299.3HCN3, HCN2, HCN4, HCN1
46arginine459.2AGT, SCN5A, NPPA, NPPB, MYH6
47pge2459.2CYP27B1, AGT, NPPB, NPPA
48cyclosporin a45 29 6011.1NPPA, AGT, NPPB, F2
49cyclic amp45 249.7HCN3, CYP27B1, NPPA, HCN2, HCN4, HCN1
50sodium45 249.0AGT, HCN3, HCN1, HCN4, NPPB, HCN2

GO Terms for genes affiliated with Sick Sinus Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.1RGS6, F2, HCN3, HCN1, HCN4, HCN2

Biological processes related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0NPPA, NPPB
2receptor guanylyl cyclase signaling pathwayGO:00716810.0NPPA, NPPB
3regulation of heart contractionGO:00801610.0HCN4, MYH6
4cation transportGO:0068129.9HCN4, HCN2
5regulation of blood vessel sizeGO:0508809.9NPPA, NPPB
6positive regulation of renal sodium excretionGO:0358159.9AGT, NPPB
7muscle contractionGO:0069369.9MYH6, HCN2, HCN4
8regulation of heart rateGO:0020279.9SCN5A, MYH6
9regulation of blood pressureGO:0082179.8MYH6, NPPA, NPPB
10positive regulation of reactive oxygen species metabolic processGO:20003799.4F2, AGT
11negative regulation of cell growthGO:0303089.4NPPB, NPPA, AGT, CYP27B1
12potassium ion transmembrane transportGO:0718059.1HCN3, HCN1, HCN4, HCN2
13regulation of membrane potentialGO:0423919.1HCN2, HCN4, HCN1, HCN3
14synaptic transmissionGO:0072688.9HCN2, HCN4, HCN1, HCN3

Molecular functions related to Sick Sinus Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cation channel activityGO:0052619.9HCN4, HCN2
2hormone activityGO:0051799.2AGT, NPPA, NPPB
3sodium channel activityGO:0052728.9HCN3, HCN1, HCN4, HCN2
4cAMP bindingGO:0305528.9HCN2, HCN4, HCN1, HCN3
5voltage-gated potassium channel activityGO:0052498.8HCN2, HCN4, HCN1, HCN3

Products for genes affiliated with Sick Sinus Syndrome

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  • Proteins
  • Lysates
  • Antibodies

Sources for Sick Sinus Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet