SSS2
MCID: SCK014
MIFTS: 27

Sick Sinus Syndrome 2 (SSS2) malady

Categories: Genetic diseases, Cardiovascular diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Sick Sinus Syndrome 2

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Aliases & Descriptions for Sick Sinus Syndrome 2:

Name: Sick Sinus Syndrome 2 52 70 12
Sick Sinus Syndrome 2, Autosomal Dominant 24 68
Autosomal Dominant Sick Sinus Syndrome 2 70 27
Sick Sinus Syndrome 2 with or Without Cardiac Noncompaction and/or Ascending Aorta Dilation 70
Sinus Bradycardia Syndrome, Familial, Autosomal Dominant 70
Familial Sinus Bradycardia Syndrome Autosomal Dominant 70
 
Sinus Node Disease, Familial, Autosomal Dominant 70
Sinus Bradycardia Syndrome, Autosomal Dominant 24
Atrial Fibrillation with Bradyarrhythmia 70
Sss Autosomal Dominant 70
Sss2 70

Characteristics:

HPO:

64
sick sinus syndrome 2:
Inheritance: autosomal dominant inheritance
Onset and clinical course: congenital onset

Classifications:



External Ids:

OMIM52 163800
MedGen37 C1834144

Summaries for Sick Sinus Syndrome 2

About this section
UniProtKB/Swiss-Prot:70 Sick sinus syndrome 2: The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS2 onset is in utero or at birth.

MalaCards based summary: Sick Sinus Syndrome 2, also known as sick sinus syndrome 2, autosomal dominant, is related to sick sinus syndrome 1, and has symptoms including sinus bradycardia, atrial fibrillation and sick sinus syndrome. An important gene associated with Sick Sinus Syndrome 2 is HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4). Affiliated tissues include heart.

Description from OMIM:52 163800

Related Diseases for Sick Sinus Syndrome 2

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Diseases in the Sick Sinus Syndrome family:

Sick Sinus Syndrome 1 Sick Sinus Syndrome 3
sick sinus syndrome 2 Familial Sick Sinus Syndrome

Diseases related to Sick Sinus Syndrome 2 via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1sick sinus syndrome 110.8

Symptoms & Phenotypes for Sick Sinus Syndrome 2

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Symptoms by clinical synopsis from OMIM:

163800

Clinical features from OMIM:

163800

Human phenotypes related to Sick Sinus Syndrome 2:

 64
id Description HPO Frequency HPO Source Accession
1 sinus bradycardia64 HP:0001688
2 atrial fibrillation64 HP:0005110
3 sick sinus syndrome64 HP:0011704

Drugs & Therapeutics for Sick Sinus Syndrome 2

About this section

Drugs for Sick Sinus Syndrome 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PropafenoneapprovedPhase 43054063-53-54932
Synonyms:
1-(2-(2-Hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone
1-(2-(2-Hydroxy-3-propylaminopropoxy)phenyl)-3-phenylpropan-1-one
1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
1-[2-(2-Hydroxy-3-[propylamino]- propoxy)phenyl]-3-phenyl-1-propanone
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
107300-59-4
2-(2'-Hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone
34183-22-7 (hydrochloride)
54063-53-5
AB00053687
AC1L1J9C
AKOS000276940
BCBcMAP01_000079
BPBio1_000437
BRD-A26334849-001-02-1
BRD-A26334849-003-05-0
BSPBio_000397
BSPBio_001465
BSPBio_003470
C07381
CHEBI:127112
CHEMBL631
CID4932
CPD001453705
D08435
DB01182
DivK1c_000906
EINECS 258-955-6
HMS1791J07
HMS1989J07
HMS2089E09
IDI1_000906
KBio1_000906
KBio2_002092
KBio2_004660
KBio2_007228
KBio3_002974
KBioGR_000817
KBioSS_002092
 
LS-123071
Lopac0_000919
MolPort-000-881-283
MolPort-002-545-323
NCGC00015819-10
NCGC00089784-02
NCGC00089784-03
NCGC00089784-04
NCGC00089784-05
NINDS_000906
P4670_SIGMA
Prestwick0_000499
Prestwick1_000499
Prestwick2_000499
Prestwick3_000499
Propafenon Hexal
Propafenon hexal (TN)
Propafenona
Propafenona [INN-Spanish]
Propafenone (INN)
Propafenone HCl
Propafenone [INN:BAN]
Propafenone hydrochloride
Propafenone-HCl
Propafenonum
Propafenonum [INN-Latin]
Rythmol
Rythmol SR
S2500_Selleck
SAM002564228
SBB067234
SPBio_001605
SPBio_002318
Spectrum2_001603
Spectrum3_001905
Spectrum4_000209
Spectrum5_001271
Spectrum_001612
UNII-68IQX3T69U
propafenone
2
SotalolapprovedPhase 440959-24-0, 3930-20-95253
Synonyms:
.beta.-Cardone
27948-47-6
3930-20-9
4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide
4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulfonanilid
959-24-0 (mono-hydrochloride)
AB00514715
AC-19021
AC1L1JXU
BPBio1_001069
BRD-A33168282-003-03-2
BSPBio_000971
Betapace
Betapace AF
C07309
C12H20N2O3S
CCRIS 4204
CHEMBL471
CID5253
D08525
DB00489
Darob mite
Darob mite (TN)
HMS2089K09
L013427
LS-90249
Lopac0_001055
 
MJ-1999
Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)- (9CI)
MolPort-002-042-381
N-(4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}phenyl)methanesulfonamide
N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide
N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
NCGC00015919-05
NCGC00024899-02
NCGC00024899-03
Prestwick0_000966
Prestwick1_000966
Prestwick2_000966
Prestwick3_000966
SBB066409
SPBio_002892
Sorine
Sotalol
Sotalol (INN)
Sotalol HCL
Sotalol Monohydrochloride
Sotalol [INN:BAN]
Sotalolo
Sotalolum
Sotalolum [INN-Latin]
UNII-A6D97U294I
beta-Cardone
d,l-Sotalol
sotalol
3
Amiodaroneapproved, investigationalPhase 41221951-25-32157
Synonyms:
(2-Butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone
(2-butyl-1-benzofuran-3-yl)(4-{[2-(diethylamino)ethyl]oxy}-3,5-diiodophenyl)methanone
(2-butyl-1-benzofuran-3-yl)-[4-(2-diethylaminoethyloxy)-3,5-diiodophenyl]methanone
(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone
(2-butylbenzofuran-3-yl)-[4-(2-diethylaminoethoxy)-3,5-diiodo-phenyl]-methanone
(2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine
1951-25-3
2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran
2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran
2-Butyl-3-(4'-beta-N-diethylaminoethoxy-3',5'-diiodobenzoyl)benzofuran
2-Butyl-3-[3,5-diiodo-4-(2-di
2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone
2-Butyl-3-benzofuranyl p-((2-diethylamino)ethoxy)-m,m-diiodophenyl ketone
2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone
2-N-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
5-18-02-00353 (Beilstein Handbook Reference)
AB00053422
AC1L1D1R
AC1Q2VCU
ASTA Medica Brand of Amiodarone Hydrochloride
Alphapharm Brand of Amiodarone Hydrochloride
Amidorone
Aminodarone
Amio-Aqueous IV
Amiobeta
Amiodarex
Amiodarona
Amiodarona [INN-Spanish]
Amiodarone
Amiodarone (USAN/INN)
Amiodarone Base
Amiodarone HCL
Amiodarone Hydrochloride
Amiodarone [USAN:BAN:INN]
Amiodarons
Amiodaronum
Amiodaronum [INN-Latin]
Amiohexal
Amjodaronum
Ancar
Aratac
Armstrong Brand of Amiodarone Hydrochloride
Arycor
BIDD:GT0425
BIDD:PXR0146
BPBio1_000372
BRN 1271711
BSPBio_000338
BSPBio_001574
BSPBio_002580
Berenguer Infale Brand of Amiodarone Hydrochloride
Betapharm Brand of Amiodarone Hydrochloride
Bio1_000026
Bio1_000515
Bio1_001004
Bio2_000294
Bio2_000774
Braxan
C06823
C25H29I2NO3
CAS-19774-82-4
CBiol_001740
CHEBI:2663
CHEMBL633
CID2157
Corbionax
Cordarex
Cordarone
Cordarone Intravenous
D000638
D02910
DB01118
DivK1c_000079
EINECS 217-772-1
 
G Gam Brand of Amiodarone Hydrochloride
HMS1791O16
HMS1989O16
HMS2089C07
Hexal Brand of Amiodarone Hydrochloride
IDI1_000079
IDI1_034044
KBio1_000079
KBio2_000294
KBio2_000741
KBio2_002862
KBio2_003309
KBio2_005430
KBio2_005877
KBio3_000587
KBio3_000588
KBio3_001800
KBioGR_000294
KBioGR_001859
KBioSS_000294
KBioSS_000741
Ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl
Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl (7CI,8CI)
Kordaron
L 3428
L-3428
L001174
L3428
LS-87088
Labaz
Leurquin Brand of Amiodarone Hydrochloride
Lopac-A-8423
Lopac0_000122
MolPort-003-703-670
NCGC00015096-01
NCGC00015096-02
NCGC00015096-03
NCGC00015096-10
NCGC00024242-03
NCGC00024242-04
NCGC00024242-05
NCGC00024242-06
NCI60_041885
NINDS_000079
Ortacrone
Pacerone
Pharma Investi Brand of Amiodarone Hydrochloride
Prestwick0_000409
Prestwick1_000409
Prestwick2_000409
Prestwick3_000409
QTL1_000008
Rytmarone
SKF 33134-A
SKF 33134A
SPBio_001825
SPBio_002277
STK529812
STOCK1S-12240
Sanofi Winthrop Brand of Amiodarone Hydrochloride
Sedacoron
Sedacorone
Spectrum2_001813
Spectrum3_001050
Spectrum4_001190
Spectrum5_001533
Spectrum_000261
Tachydaron
UNII-N3RQ532IUT
UNM000001215003
Wyeth Brand of Amiodarone Hydrochloride
amiodarone
ethylaminoethoxy)benzoyl]benzofuran
nchembio.79-comp9
nchembio732-comp1
on
pms-Amiodarone
4Potassium Channel BlockersPhase 4180
5Peripheral Nervous System AgentsPhase 423689
6Sodium Channel BlockersPhase 41593
7SympatholyticsPhase 4580
8Adrenergic AgentsPhase 45352
9Vasodilator AgentsPhase 43543
10Diuretics, Potassium SparingPhase 41917
11Neurotransmitter AgentsPhase 418340
12Cytochrome P-450 Enzyme InhibitorsPhase 4, Phase 33917
13Anti-Arrhythmia AgentsPhase 43093
14Adrenergic beta-AntagonistsPhase 41193
15Adrenergic AntagonistsPhase 41573
16Cytochrome P-450 CYP1A2 InhibitorsPhase 4, Phase 3572
17Autonomic AgentsPhase 410150
18Cytochrome P-450 CYP2C9 InhibitorsPhase 4669
19Cytochrome P-450 CYP3A InhibitorsPhase 41715
20Cytochrome P-450 CYP2D6 InhibitorsPhase 4727
21
Cephalexinapproved, vet_approvedPhase 35115686-71-227447
Synonyms:
(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
105879-42-3 (mono-hydrochloride, mono-hydrate)
105879-42-3 (mono-hydrochloride,mono-hydrate)
14101-75-8
15686-71-2
15686-71-2 (Parent)
17692-47-6
23325-78-2
23325-78-2 (mono-hydrate)
38932-40-0 (mono-hydrochloride salt)
66905-57-5 (di-hydrate)
7-(D-2-Amino-2-phenylacetamido)-3-methyl-delta (sup 3)-cephem-4- carboxylic acid
7-(D-2-Amino-2-phenylacetamido)-3-methyl-delta3-cephem-4-carboxylic acid
7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid
7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid
AC1L1D8M
AC1L1Y1M
AC1O6OSE
AKOS004119846
Adcadina
Ades[prex
Alcephin
Alexin
Alsporin
Ambal
Anhydrous cefalexin
Anhydrous cephalexin
Aristosporin
Azabort
BB_NC-1052
BPBio1_000501
BRD-K90733503-002-03-6
BRN 0965503
BSPBio_000455
Bactopenor
Beliam
Biocef
C06895
C08099
C16H17N3O4S
CEX
CHEBI:3534
CHEBI:3535
CHEMBL1200544
CHEMBL1727
CID27447
CID62921
CID6560168
CPD-9227
CPD000338536
Carnosporin
Cefa-iskia
Cefablan
Cefacet
Cefadal
Cefadin
Cefadina
Cefalekey
Cefaleksin
Cefalessina
Cefalessina [DCIT]
Cefalexgobens
Cefalexin
Cefalexin (JP15)
Cefalexin Scand Pharm
Cefalexin Sodium
Cefalexin anhydrous
Cefalexin generics
Cefalexina
Cefalexina Northia
Cefalexina Richet
Cefalexina [INN-Spanish]
Cefalexine
Cefalexine [INN-French]
Cefalexinum
Cefalexinum [INN-Latin]
Cefalin
Cefalival
Cefaloto
Cefaseptin
Cefax
Ceffanex
Cefibacter
Ceflax
Ceforal
Cefovit
Celexin
Cepastar
Cepexin
Cephacillin
Cephalex von ct
Cephalexin (USP)
Cephalexin (anhydrous)
Cephalexin 1-hydrate
Cephalexin 1-wasser
Cephalexin [USAN:BAN]
Cephalexin anhydrous
Cephalexin hydrate
Cephalexin monohydrate
Cephalexin, (6R-(6alpha,7beta))-Isomer
Cephalexine
Cephalexinum
Cephalobene
Cephanasten
Cephaxin
Cephin
Cepol
Ceporex
Ceporex Forte
Ceporexin
Ceporexin-E
Ceporexine
Check
Cophalexin
Cusisporina-Cefalox
Céfalexine
D00263
 
D00906
DB00567
Domucef
Doriman
Durantel
Durantel DS
EINECS 239-773-6
Ed A-Ceph
Efemida
Erocetin
Factagard
Felexin
Fexin
HMS1569G17
HMS2051A04
HSDB 3022
Henina Oral
Ibilex
Ibrexin
Inphalex
KS-1134
Karilexina
Kefalospes
Keflet
Keflex
Keflex (TN)
Kefolan
Keforal
Keftab
Keftab (TN)
Kekrinal
Kidolex
L-Keflex
LS-149963
LS-173992
LS-174191
Lafarine
Larixin
Lenocef
Lexibiotico
Lilly 66873
Loisine
Lonflex
Lopilexin
Losporal
MLS000759527
Madlexin
Maksipor
Mamalexin
Mamlexin
Medolexin
Medoxine
MolPort-002-507-304
MolPort-006-823-789
NCGC00159522-02
NCGC00159522-03
Neokef
Neolexina
Noveol
Novolexin
Nufex
Oracef
Oriphex
Oroxin
Ortisporina
Ospexin
Palitrex
Panixine Disperdose
Panixine disperdose (TN)
Pectril
Prestwick0_000358
Prestwick1_000358
Prestwick2_000358
Prestwick3_000358
Prestwick_750
Prindex
Pyassan
Rilexine
Roceph
Roceph Distab
Rogevil
S 6437
SAM001246761
SMR000338536
SPBio_002376
SQ 20248
Sanaxin
Sartosona
Sencephalin
Sepexin
Servicef
Servispor
Sialexin
Sinthecillin
Sintolexyn
Sporicef
Sporidex
Syncl
Syncle
Synecl
Tepaxin
Theratrex
Tokiolexin
UNII-5SFF1W6677
UNII-OBN7UDS42Y
Uphalexin
Viosporine
Voxxim
Winlex
ZINC01530596
ZINC03830500
Zabytrex
Zozarine
cefalexin hydrate
cefalexin monohydrate
cefalexin.H2O
cephalexin
cephalexin.H2O
22
Clindamycinapproved, vet_approvedPhase 317218323-44-929029
Synonyms:
13441-63-9
16669-21-9
18323-44-9
21462-39-5 (mono-hydrochloride)
24620-78-8
24696-19-3
58207-19-5
7(S)-Chloro-7-deoxylincomycin
7-CDL
7-Chloro-7-deoxylincomycin
7-Chlorolincomycin
7-Deoxy-7(S)-chlorolincomycin
AC1L1EGQ
AC1L1GLA
AC1L9JV8
AC1MHD7N
AC1MHE1M
AC1MHUOE
AC1MHX4G
AC1NWAKO
AC1O7ENS
AC1O7GED
AC1OFCIP
AC1OFCIV
AC1OFCJ1
AC1OFCJ7
AC1OIBYJ
AC1OIBYL
AC1OIBYN
AC1Q2V4O
Antirobe
BIDD:GT0418
BPBio1_000236
BRD-A23034328-003-03-4
BSPBio_000214
BSPBio_002049
C06914
C18H33ClN2O5S
CAS-21462-39-5
CHEBI:3745
CHEMBL187
CID2786
CID29029
CID3000512
CID3001928
CID3032758
CID3034218
CID446598
CID5702026
CID6602476
CID6604361
CID7048642
CID7048644
CID7048646
CID7048648
CID7276014
CID7276016
CID7276018
CID9812677
CLDM
CLINDA & IL-12
CLY
Chlolincocin
Chlorlincocin
Chlorodeoxylincomycin
Chlorolincomycin
Cleocin
Cleocin (TN)
Cleocin (tn)
Cleocin HCl
Cleocin Hcl
Cleocin Pediatric
Cleocin Phosphate
Cleocin T
Cleocin T Gel
Cleocin T Lotion
Cleocin T Topical Solution
 
Clinda-Derm
ClindaDerm
Clindagel
Clindamicina
Clindamicina [INN-Spanish]
Clindamycin
Clindamycin & Interleukin 12
Clindamycin & VRC3375
Clindamycin (USAN/INN)
Clindamycin Hcl
Clindamycin Hydrochloride
Clindamycin Phosphate
Clindamycin [USAN:BAN:INN]
Clindamycine
Clindamycine [French]
Clindamycine [INN-French]
Clindamycinum
Clindamycinum [INN-Latin]
Clindesse
Clindets
Clinimycin
D00277
DB01190
Dalacin
Dalacin C
Dalacin C Flavored Granules
Dalacin C Phosphate
Dalacin T Topical Solution
Dalacine
DivK1c_000464
EINECS 242-209-1
Evoclin
HMS2089A05
HMS2089N16
HSDB 3037
I06-0826
IDI1_000464
KBio1_000464
KBio2_000638
KBio2_003206
KBio2_005774
KBio3_001269
KBioGR_000844
KBioSS_000638
Klimicin
Klindan 300
LS-187128
LS-98131
MLS001183714
Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside
MolPort-002-323-206
MolPort-002-964-479
NCGC00016752-01
NCGC00178843-01
NCGC00179636-01
NINDS_000464
Prestwick0_000137
Prestwick1_000137
Prestwick2_000137
Prestwick3_000137
ResiDerm A
SMP2_000295
SMR000677917
SPBio_000670
SPBio_002153
STK177246
STOCK1N-31150
Sobelin
Spectrum2_000885
Spectrum3_000355
Spectrum4_000292
Spectrum5_001525
Spectrum_000158
U 21251
U-21,251
U-21251
UNII-3U02EL437C
Zindaclin
clindamycin
23
OfloxacinapprovedPhase 323682419-36-14583
Synonyms:
( -)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure
(+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid
(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
(+/-)-Floxin
118120-51-7 (hydrochloride)
33703_FLUKA
33703_RIEDEL
8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid
82419-36-1
83380-47-6
85344-55-4
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
AB00513820
AC-7616
AC1L1IHM
AKOS001033517
BB_SC-1252
BPBio1_000345
BRD-A24228527-001-05-9
BRN 3657947
BSPBio_000313
BSPBio_003117
Bactocin
C07321
C18H20FN3O4
CCRIS 5233
CHEBI:7731
CHEMBL4
CID4583
CPD000058192
D00453
DB01165
DEXTROFLOXACINE
DL 8280
DL-8280
DL-8280, HOE-280, Exocin, Flobacin, Floxin, Floxil, Monoflocet, Ofloxacin
Danoflox
DivK1c_000721
EU-0100904
Effexin
Exocin
Exocine
FLOXIN IN DEXTROSE 5%
FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER
Flobacin
Flodemex
Flotavid
Flovid
Floxal
Floxil
Floxin
Floxin (TN)
Floxin otic
Floxstat
Fugacin
HMS1568P15
HMS1921H12
HMS2090F07
HMS2092B10
HMS502E03
HOE 280
Hoe-280
I06-0112
I06-0380
IDI1_000721
Inoflox
KBio1_000721
KBio2_001666
KBio2_004234
KBio2_006802
KBio3_002617
KBioGR_000667
KBioSS_001666
Kinflocin
Kinoxacin
LS-133259
Liflox
Lopac0_000904
Loxinter
MLS000028749
MLS001074203
Marfloxacin
Medofloxine
Mergexin
MolPort-000-422-241
MolPort-000-873-068
NCGC00015772-02
NCGC00015772-10
 
NCGC00094219-01
NCGC00094219-02
NCGC00094219-03
NCGC00094219-04
NCGC00094219-05
NCGC00094219-06
NCGC00178284-01
NCGC00178284-02
NINDS_000721
NSC727071
Novecin
Nufafloqo
O 8757
O-Flox
O8757_SIGMA
OFLX
OFX
ORF 18489
ORF-28489
Obide
Occidal
Ocuflox
Ofcin
Oflin
Oflocee
Oflocet
Oflocin
Oflodal
Oflodex
Oflodura
Oflox
Ofloxacin (JP15/USP/INN)
Ofloxacin Otic
Ofloxacin [USAN:BAN:INN:JAN]
Ofloxacin, (S)-Isomer
Ofloxacina
Ofloxacina [DCIT]
Ofloxacine
Ofloxacine [French]
Ofloxacino
Ofloxacino [Spanish]
Ofloxacinum
Ofloxacinum [Latin]
Ofloxin
Ofus
Onexacin
Operan
Oprea1_242882
Orocin
Otonil
Oxaldin
PT 01
Pharflox
Praxin
Prestwick0_000237
Prestwick1_000237
Prestwick2_000237
Prestwick3_000237
Puiritol
Qinolon
Qipro
Quinolon
Quotavil
Rilox
Ru-43280
S1463_Selleck
SAM002264629
SMR000058192
SPBio_001387
SPBio_002234
SPECTRUM1502044
STK256723
Sinflo
Spectrum2_001464
Spectrum3_001499
Spectrum4_000324
Spectrum5_001063
Spectrum_001186
Tabrin
Taravid
Tariflox
Tarivid
Telbit
Tructum
UNII-A4P49JAZ9H
Uro Tarivid
Viotisone
Visiren
WP-0405
XED
Zanocin
ofloxacin
24
Levofloxacinapproved, investigationalPhase 3236100986-85-4149096
Synonyms:
(−
(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate
(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate
(-)-Ofloxacin
(3S)-(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
(3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
(R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(R)-isomer
(S)-(-)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid
(S)-(-)-Ofloxacin
(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
(S)-Ofloxacin
)-Ofloxacin
100986-85-4
100986-86-5
28266_FLUKA
28266_SIGMA
AC-7593
AC1L3YF8
Aeroquin
Ambap100986-85-4
BRD-K09471561-001-06-7
BSPBio_002689
C07660
C18H20FN3O4
C18H20FN3O4.H2O
CCRIS 4073
CCRIS 4074
CHEMBL33
CID149096
CPD000466387
Cravit
Cravit (TN)
Cravit Ophthalmic
D08120
DB01137
DR 3354
DR-3355
DR-3355: L-isomer of ofloxacin
DR3355
Elequine
Floxacin
Floxel
Floxin
HMS1922J07
HMS2051G04
HMS2090O10
HMS2093E18
HR 355
HR-355
Iquix
KBio2_002199
KBio2_004767
KBio2_007335
KBio3_001909
 
KBioGR_001605
KBioSS_002199
L-Ofloxacin
L-ofloxacin
L0193
LEVAQUIN IN DEXTROSE 5% IN PLASTIC CONTAINER
LEVOFLOXACIN
LFX
LS-133260
LS-171761
LVX
Leroxacin
Lesacin
Levaquin
Levofloxacin
Levofloxacin (INN)
Levofloxacin [USAN:INN:JAN]
Levofloxacin hydrate
Levofloxacin tablet, suspension or intravenous
Levofloxacine
Levofloxacine [INN-French]
Levofloxacino
Levofloxacino [INN-Spanish]
Levofloxacinum
Levofloxacinum [INN-Latin]
Levokacin
Levox
Levoxacin
MLS000759524
MLS001165709
MLS001423977
MP-376
MolPort-002-885-835
Mosardal
NCGC00178529-01
Nofaxin
Ofloxacin
Ofloxacin S-(-)-form
Oftaquix
Quixin
R-Ofloxacin
RWJ 25213-097
RWJ-25213
Reskuin
S-(-)-Ofloxacin
S1940_Selleck
SAM001246758
SMR000466387
SPBio_001891
SPECTRUM1504260
Spectrum2_001676
Spectrum3_000995
Spectrum4_001123
Spectrum5_001438
Spectrum_001719
Tavanic
Volequin
d-Levofloxacin
25
Bacitracinapproved, vet_approvedPhase 3401405-87-4439542, 10909430
Synonyms:
(4R)-4-[[(2S)-2-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S,3S)-1-[[(3S,6R,9S,12R,15R,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
(4R)-4-[[(2S)-2-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S,3S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
11702_FLUKA
11702_SIGMA
22601-59-8
4-[[2-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[1-[[3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-butan-2-yl-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
46084_RIEDEL
AB00513964
AC1L22YV
AC1O6F67
AC1O8Q0J
AC1Q6GKZ
Altracin
B0125_SIGMA
BPBio1_000878
BSPBio_000798
Baciguent
Baciquent
Bacitracin A
Bacitracin A1
Bacitracin A2a
Bacitracin a2a
C15482
 
CHEMBL1200558
CID10909430
CID6474109
CID65281
CID6714010
Citracin
EINECS 245-115-9
Fortracin
HMS1570H20
L-Asparagine, N-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-.alpha.-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-.alpha.-as
LS-23608
MLS002695992
MolPort-003-926-019
NSC 45737
Prestwick1_000919
Prestwick2_000919
Prestwick3_000919
SMR001562136
SPBio_002987
Solu-Tracin 50
UNII-DDA3RRX0P7
bacitracin
n-{[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazol-4-yl]carbonyl}leucyl-|A-glutamyl-n-[3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-(butan-2-yl)-6-(carboxymethyl)-9-(1h-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]isoleucinamide
partyl-, (10.4)-lactam
26ImmunoglobulinsPhase 2, Phase 36394
27gamma-GlobulinsPhase 2, Phase 3326
28Pharmaceutical SolutionsPhase 2, Phase 38192
29Immunoglobulins, IntravenousPhase 2, Phase 3333
30AntibodiesPhase 2, Phase 36394
31Rho(D) Immune GlobulinPhase 2, Phase 3326
32Polymyxin BPhase 349
33Topoisomerase InhibitorsPhase 35069
34Renal AgentsPhase 3754
35PolymyxinsPhase 362
36Clindamycin phosphatePhase 3172
37Anti-Bacterial AgentsPhase 311226
38Antibiotics, AntitubercularPhase 37180
39Anti-Infective Agents, LocalPhase 31880
40Anti-Infective AgentsPhase 322062
41Antitubercular AgentsPhase 31343
42Clindamycin palmitatePhase 3172
43
MentholapprovedPhase 226062216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol
44MuramidasePhase 29
45LactoferrinPhase 251

Interventional clinical trials:

(show all 30)
idNameStatusNCT IDPhase
1Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity.Unknown statusNCT00156741Phase 4
2Antiarrhythmic Drugs Assessment in Preventing Atrial FibrillationUnknown statusNCT02145546Phase 4
3Austria Study - Analysis of Difference Between Active and Passive Fixation LeadsCompletedNCT00180557Phase 4
4Spontaneous Atrio Ventricular Conduction PreservationCompletedNCT00655213Phase 4
5PANORAMA Observational StudyCompletedNCT00382525Phase 4
6Syncope: Pacing or Recording in the Later YearsActive, not recruitingNCT01423994Phase 4
7Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic ShockEnrolling by invitationNCT02668432Phase 4
8Virtual Clinic Pacemaker Follow-upTerminatedNCT00475124Phase 4
9Phase 2/3 Study of IGSC, 20% in PIDDCompletedNCT01218438Phase 2, Phase 3
10Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections.RecruitingNCT02809131Phase 3
11The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus SyndromeTerminatedNCT00236158Phase 2, Phase 3
12Left Ventricular Septum Pacing in Patients by Transvenous Approach Through the Inter-ventricular SeptumCompletedNCT01609738Phase 1, Phase 2
13Second Study on Cardio-neuromodulation in HumansRecruitingNCT02954666Phase 2
14Gulf War Illness Nasal Irrigation StudyActive, not recruitingNCT01700725Phase 2
15RV Septal Versus Minimized RV Pacing in Sick Sinus SyndromeUnknown statusNCT01477138
16Left Ventricular Function and Remodelling During Permanent PacingUnknown statusNCT00228241
17Left Ventricular Pacing to Prevent Iatrogenic TR Pilot StudyUnknown statusNCT02314897
18A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node DysfunctionUnknown statusNCT02027909
19Minimizing Ventricular PacingUnknown statusNCT01611389
20The Atrial High Rate Episodes in Pacemaker PatientsCompletedNCT00627328
21SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular ConductionCompletedNCT00284830
22Natural Evolution of AV Conduction Disorders in Patients Implanted With Cardiac PacemakersCompletedNCT00531037
23Ingenio Device Algorithm StudyCompletedNCT01441583
24Left Ventricular Pacing to Avoid Cardiac Enlargement StudyRecruitingNCT01302717
25Immune Regulation in Patients With Common Variable Immunodeficiency and Related SyndromesRecruitingNCT00001244
26Prospective Identification of Long QT Syndrome in Fetal LifeRecruitingNCT02876380
27Impact of Septal Vs Apical Pacing on Right and Left Ventricular PerformanceActive, not recruitingNCT01798043
28Safety and Performance Study of the INGEVITY LeadActive, not recruitingNCT01688843
29Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR ModeActive, not recruitingNCT02586480
30Af Ablation In Brady-Tachy SyndromeTerminatedNCT00740272

Search NIH Clinical Center for Sick Sinus Syndrome 2

Genetic Tests for Sick Sinus Syndrome 2

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Genetic tests related to Sick Sinus Syndrome 2:

id Genetic test Affiliating Genes
1 Sick Sinus Syndrome 2, Autosomal Dominant27 24 HCN4

Anatomical Context for Sick Sinus Syndrome 2

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MalaCards organs/tissues related to Sick Sinus Syndrome 2:

36
Heart

Publications for Sick Sinus Syndrome 2

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Variations for Sick Sinus Syndrome 2

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UniProtKB/Swiss-Prot genetic disease variations for Sick Sinus Syndrome 2:

70
id Symbol AA change Variation ID SNP ID
1HCN4p.Asp553AsnVAR_026534rs104894485
2HCN4p.Ser672ArgVAR_026535rs104894488
3HCN4p.Ala485ValVAR_066614

Clinvar genetic disease variations for Sick Sinus Syndrome 2:

5
id Gene Variation Type Significance SNP ID Assembly Location
1HCN4NM_ 005477.2(HCN4): c.1444G> A (p.Gly482Arg)SNVLikely pathogenicrs794727637GRCh37Chr 15, 73622060: 73622060
2HCN4NM_ 005477.2(HCN4): c.1920_ 1932dupCAGCGTGCTCACC (p.Lys645Glnfs)duplicationPathogenicrs1057519274GRCh38Chr 15, 73325001: 73325013
3HCN4NM_ 005477.2(HCN4): c.1444G> C (p.Gly482Arg)SNVPathogenicrs794727637GRCh38Chr 15, 73329719: 73329719
4HCN4NM_ 005477.2(HCN4): c.1441T> C (p.Tyr481His)SNVPathogenicrs1057519275GRCh37Chr 15, 73622063: 73622063
5HCN4NM_ 005477.2(HCN4): c.1241C> G (p.Ala414Gly)SNVPathogenicrs1057519276GRCh37Chr 15, 73624602: 73624602
6HCN4NM_ 005477.2(HCN4): c.2016C> A (p.Ser672Arg)SNVPathogenicrs104894488GRCh37Chr 15, 73616557: 73616557
7HCN4NM_ 005477.2(HCN4): c.1631delC (p.Pro544Argfs)deletionPathogenicrs1057519015GRCh38Chr 15, 73325404: 73325404
8HCN4NM_ 005477.2(HCN4): c.1657G> A (p.Asp553Asn)SNVPathogenicrs104894485GRCh37Chr 15, 73617719: 73617719
9HCN4NM_ 005477.2(HCN4): c.1438G> C (p.Gly480Arg)SNVPathogenicrs121908411GRCh37Chr 15, 73622066: 73622066

Expression for genes affiliated with Sick Sinus Syndrome 2

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Search GEO for disease gene expression data for Sick Sinus Syndrome 2.

Pathways for genes affiliated with Sick Sinus Syndrome 2

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GO Terms for genes affiliated with Sick Sinus Syndrome 2

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Sources for Sick Sinus Syndrome 2

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet