SCD
MCID: SCK003
MIFTS: 72

Sickle Cell Anemia (SCD) malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases, Nephrological diseases, Reproductive diseases, Bone diseases, Endocrine diseases categories
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Summaries for Sickle Cell Anemia

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43NIH Rare Diseases, 34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Sickle cell anemia is a disease in which your body produces abnormally shaped red blood cells. the cells are shaped like a crescent or sickle. they don't last as long as normal, round red blood cells. this leads to anemia. the sickle cells also get stuck in blood vessels, blocking blood flow. this can cause pain and organ damage. a genetic problem causes sickle cell anemia. people with the disease are born with two sickle cell genes, one from each parent. if you only have one sickle cell gene, it's called sickle cell trait. about 1 in 12 african americans has sickle cell trait. the most common symptoms are pain and problems from anemia. anemia can make you feel tired or weak. in addition, you might have shortness of breath, dizziness, headaches, or coldness in the hands and feet. a blood test can show if you have the trait or anemia. most states test newborn babies as part of their newborn screening programs. sickle cell anemia has no widely available cure. treatments can help relieve symptoms and lessen complications. researchers are investigating new treatments such as blood and marrow stem cell transplants, gene therapy, and new medicines. nih: national heart, lung, and blood institute

MalaCards: Sickle Cell Anemia, also known as hemoglobin sc disease, is related to alpha thalassemia and beta thalassemia. An important gene associated with Sickle Cell Anemia is HBB (hemoglobin, beta), and among its related pathways are thyroid hormone metabolism II (via conjugation and/or degradation) and AHR Pathway. The drug sodium phenylbutyrate and the compounds uridine diphosphate and glucuronide have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and heart.

NIH Rare Diseases:43 Sickle cell anemia is a disease in which the body produces abnormally shaped red blood cells that have a crescent or sickle shape. these cells do not last as long as normal, round, red blood cells, which leads to anemia (low number of red blood cells). the sickle cells also get stuck in blood vessels, blocking blood flow. signs and symptoms of sickle cell disease usually begin in early childhood and may include anemia, repeated infections, and periodic episodes of pain (called crises). this condition is caused by mutations in the hbb gene and is inherited in an autosomal recessive pattern. treatment typically focuses on controlling symptoms and may include pain medicines during crises; hydroxyurea to reduce the number of pain episodes; antibiotics and vaccines to prevent bacterial infections; and blood transfusions. last updated: 11/10/2011

Wikipedia:65 Sickle-cell disease (SCD), or sickle-cell anaemia (SCA) or drepanocytosis, is a hereditary blood... more...

Description from OMIM:47 603903

Aliases & Classifications for Sickle Cell Anemia

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Sources:
8Disease Ontology, 9diseasecard, 65Wikipedia, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 49Orphanet, 34MedlinePlus, 31LifeMap Discovery™, 20GeneTests, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:



Characteristics (Orphanet epidemiological data):

49
sickle cell anemia:
Inheritance: Autosomal recessive; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

sickle cell anemia 8 9 65 43 47 10 49 34 31
hemoglobin sc disease 8 43 20 62
hemoglobin s disease 65 43
sickle cell disease 43 49
sickle-cell/hb-c disease without crisis 8
sickling disorder due to hemoglobin s 43
hemoglobin s disease without crisis 8
hb-ss disease without crisis 8
anemia, sickle cell 62
sickle cell trait 62
hb-s/hb-c disease 8
herrick's anemia 65
drepanocytosis 8
hb sc disease 8
hb s disease 65
hbs disease 43
scd 65


External Ids:

Disease Ontology8 DOID:10923
NCIt40 C34383
OMIM47 603903
ICD9CM27 282.6, 282.60
MeSH35 D000755
MESH via Orphanet36 D000755
SNOMED-CT via Orphanet59 127040003, 417357006
ICD10 via Orphanet26 D57.0, D57.1, D57.2
UMLS via Orphanet63 C0002895

Related Diseases for Sickle Cell Anemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Sickle Cell Anemia:



Diseases related to sickle cell anemia

Symptoms for Sickle Cell Anemia

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47OMIM
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Clinical features from OMIM:

603903

Drugs & Therapeutics for Sickle Cell Anemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Sickle Cell Anemia

Search NIH Clinical Center for Sickle Cell Anemia

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Sickle Cell Anemia cell therapies at LifeMap Discovery.

Genetic Tests for Sickle Cell Anemia

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20GeneTests
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Genetic tests related to Sickle Cell Anemia:

id Genetic test Affiliating Genes
1 Hemoglobin Sc20 HBB

Anatomical Context for Sickle Cell Anemia

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Sickle Cell Anemia:

33
Bone, Testes, Heart, Lung, Endothelial, Bone marrow, Liver, Brain, Spleen, Kidney, Monocytes, Myeloid, Placenta, Colon, Skin, Spinal cord, Pancreas

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Sickle Cell Anemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodPeripheral BloodErythrocytes Potential therapeutic candidate, affected by disease

Animal Models for Sickle Cell Anemia or affiliated genes

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Publications for Sickle Cell Anemia

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52PubMed
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Articles related to Sickle Cell Anemia:

(show top 50)    (show all 617)
idTitleAuthorsYear
1
TNF-I+, IFN-I^, IL-10, and IL-4 levels were elevated in a murine model of human sickle cell anemia maintained on a high protein/calorie diet. (24281564)
2014
2
Bacteremia Caused by Microbacterium binotii in a Patient with Sickle Cell Anemia. (24197889)
2014
3
Effect of extended-release niacin on serum lipids and on endothelial function in adults with sickle cell anemia and low high-density lipoprotein cholesterol levels. (24035168)
2013
4
Malnutrition in Sickle Cell Anemia: Implications for Infection, Growth, and Maturation. (24312698)
2013
5
Spectral detection of sickle cell anemia and thalassemia. (24284096)
2013
6
Transcranial Doppler velocity and brain MRI/MRA changes in children with sickle cell anemia on chronic transfusions to prevent primary stroke. (23625812)
2013
7
Severe painful vaso-occlusive crises and mortality in a contemporary adult sickle cell anemia cohort study. (24224021)
2013
8
Pain and other non-neurological adverse events in children with sickle cell anemia and previous stroke who received hydroxyurea and phlebotomy or chronic transfusions and chelation: results from the SWiTCH clinical trial. (23861242)
2013
9
Type 1 diabetes mellitus in a patient with homozygous sickle cell anemia. (23813357)
2013
10
Tissue factor and thrombin in sickle cell anemia. (22398014)
2012
11
Zoster myelitis in sickle cell anemia. (22246022)
2012
12
Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans. (22139998)
2012
13
Letter by Farmakis and Aessopos regarding article, "echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United kingdom". (22586296)
2012
14
Advantages of isovolemic hemodilution-red cell exchange therapy to prevent recurrent stroke in sickle cell anemia patients. (21786315)
2011
15
Spontaneous epidural hematoma: a rare complication of sickle cell anemia. (21483142)
2011
16
Gated myocardial perfusion scintigraphy in children with sickle cell anemia: correlation with echocardiography. (21458111)
2011
17
Proteinuria among adult sickle cell anemia patients in Nigeria. (21311153)
2011
18
Sickle cell anemia pathophysiology: back to the data. (21264895)
2011
19
Determination of I^ haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil. (21931513)
2011
20
Homozygous sickle cell anemia and secondary complications: a case study. (21657139)
2011
21
Tibial chronic osteomyelitis due to Propionibacterium acnes in a patient with sickle cell anemia. (19913448)
2010
22
Atrial septal defect closure on cardiopulmonary bypass in a sickle cell anemia: role of hydroxyurea and partial exchange transfusion. (20442545)
2010
23
Safety of pegylated interferon and ribavirin therapy for chronic hepatitis C in patients with sickle cell anemia. (21160993)
2010
24
Sickle cell anemia and vascular dysfunction: the nitric oxide connection. (20578237)
2010
25
Neurocognitive complications of sickle cell anemia in adults. (20460628)
2010
26
Serum melatonin level and oxidative stress in sickle cell anemia. (20888275)
2010
27
A normative study of the components of niprisan--an herbal medicine for sickle cell anemia. (22435571)
2010
28
Pulmonary thrombi are not detected by 3D magnetic resonance angiography in adults with sickle cell anemia and an elevated triscuspid regurgitant jet velocity. (19743468)
2009
29
Human platelet alloantigens (HPA) 1, HPA2, HPA3, HPA4, and HPA5 polymorphisms in sickle cell anemia patients with vaso-occlusive crisis. (19702628)
2009
30
Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease. (19644138)
2009
31
The prevalence of sickle cell anemia in Saudi children and adolescents. A community-based survey. (19271087)
2009
32
Usefulness and limitations of Bayesian network model as a mortality risk assessment tool in sickle cell anemia. (19338040)
2009
33
Acute splenic sequestration in a cohort of children with sickle cell anemia. (19319450)
2009
34
Effect of transfusion therapy on cerebral vasculopathy in children with sickle-cell anemia. (19059938)
2009
35
Prenatal diagnosis of sickle cell anemia and beta-thalassemia in southern Turkey. (19065329)
2008
36
A simple index using age, hemoglobin, and aspartate transaminase predicts increased intracerebral blood velocity as measured by transcranial Doppler scanning in children with sickle cell anemia. (18490379)
2008
37
Chronic multifocal osteomyelitis due to Clostridium difficile in an adolescent with sickle cell anemia. (18724265)
2008
38
Cytokine concentrations in bone marrow of stable sickle cell anemia patients. (17362693)
2007
39
Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia. (17262858)
2007
40
Gene interactions and stroke risk in children with sickle cell anemia. (14615367)
2004
41
Immunotactoid glomerulopathy in sickle cell anemia. (11198611)
2001
42
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. (17264555)
2001
43
Growth hormone and insulin-like growth factor I axis and growth of children with different sickle cell anemia haplotypes. (11563770)
2001
44
Effect of alpha-thalassemia and beta-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil. (8892730)
1996
45
Cardiovascular function during rest and exercise in patients with sickle-cell anemia and coexisting alpha thalassemia-2. (8638648)
1996
46
Smoking is a factor in causing acute chest syndrome in sickle cell anemia. (1578502)
1992
47
Ultrasonography: hepatic vein thrombosis in sickle cell anemia. (7114404)
1982
48
Sickle cell trait/hereditary persistence of fetal hemoglobin trait. Misdiagnosis as sickle cell anemia by newborn screening. (517474)
1979
49
HYPERSPLENISM IN SICKLE CELL ANEMIA. (14170620)
1964
50
Pregnancy with sickle cell anemia and placenta accreta. (14942979)
1952

Variations for Sickle Cell Anemia

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Sickle Cell Anemia:

1
id Gene Name Type Significance SNP ID Assembly Location
1HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232
2HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232
3HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232
4HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232
5HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232
6HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232
7HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232
8HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232
9HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenic, otherrs334GRCh37Chr 11, 5248232: 5248232

Expression for genes affiliated with Sickle Cell Anemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sickle Cell Anemia

Search GEO for disease gene expression data for Sickle Cell Anemia.

Pathways for genes affiliated with Sickle Cell Anemia

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 51PharmGKB, 60Thomson Reuters, 55Reactome, 30KEGG
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Pathways related to Sickle Cell Anemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6UGT1A10, UGT1A3
2
Show member pathways
AhR pathway38
9.6UGT1A6, UGT1A1
3
Show member pathways
bupropion degradation38
methylglyoxal degradation III38
nicotine degradation III38
nicotine degradation IV38
9.4UGT1A4, UGT1A10
4
Show member pathways
Nicotine metabolism38
9.0UGT1A4, UGT1A9
58.8UGT1A1, UGT1A6, UGT1A9
6
Show member pathways
8.4UGT1A3, UGT1A1, UGT1A9, UGT1A10
7
Show member pathways
7.7UGT1A9, UGT1A3, UGT1A4, UGT1A6, UGT1A1
87.7UGT1A4, UGT1A1, UGT1A6, UGT1A9, UGT1A3
97.6UGT1A6, UGT1A10, UGT1A3, UGT1A4, UGT1A9
10
Show member pathways
6.7UGT1A1, UGT1A6, UGT1A4, UGT1A7, UGT1A3, UGT1A9
11
Show member pathways
6.4UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7
12
Show member pathways
tetrapyrrole biosynthesis38
heme degradation38
Heme Biosynthesis38
heme biosynthesis38
heme biosynthesis from uroporphyrinogen-III I38
6.4UGT1A9, UGT1A5, UGT1A6, UGT1A1, UGT1A10, UGT1A3
13
Show member pathways
6.4UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5
14
Show member pathways
6.4UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5
15
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
6.4UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5
16
Show member pathways
6.4UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5
17
Show member pathways
6.2UGT1A3, UGT1A4, UGT1A10, UGT1A7, UGT1A5, UGT1A6

Compounds for genes affiliated with Sickle Cell Anemia

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45Novoseek, 24HMDB, 29IUPHAR, 51PharmGKB, 11DrugBank
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Compounds related to Sickle Cell Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1uridine diphosphate457.1UGT1A1, UGT1A6, UGT1A9, UGT1A10, UGT1A3, UGT1A4
2glucuronide457.0UGT1A1, UGT1A6, UGT1A9, UGT1A10, UGT1A3, UGT1A4
3cotinine45 248.0UGT1A6, UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7
4ethyl glucuronide45 248.0UGT1A7, UGT1A1, UGT1A6, UGT1A9, UGT1A10, UGT1A3
5Cotinineglucuronide246.9UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A9, UGT1A1
6Dehydroisoandrosterone 3-glucuronide246.9UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4
7Estriol-3-glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
8Dehydroepiandrosterone 3-glucuronide246.9UGT1A7, UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10
9Etiocholanolone glucuronide246.9UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7
10Glycochenodeoxycholic acid 3-glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
11Estrone glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
12Bilirubin246.9UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7
13Bilirubin glucuronide246.9UGT1A7, UGT1A4, UGT1A3, UGT1A1, UGT1A6, UGT1A5
14Cholestane-3,7,12,25-tetrol-3-glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
15Cholesterol glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
16Cortolone-3-glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
17Cholic acid glucuronide246.9UGT1A7, UGT1A4, UGT1A1, UGT1A6, UGT1A5, UGT1A9
18Testosterone sulfate246.9UGT1A7, UGT1A4, UGT1A1, UGT1A6, UGT1A5, UGT1A9
19Thyroxine glucuronide246.9UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A9, UGT1A5
20trans-3-Hydroxycotinine glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
21Tetrahydroaldosterone-3-glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
22Triiodothyronine glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
23Tyramine glucuronide246.8UGT1A3, UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A1
24Uridine 5'-diphosphate246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
25Isovalerylglucuronide246.8UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7
26Ketoprofen glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
27Inodxyl glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
28Testosterone glucuronide246.8UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A5
29Lithocholate 3-O-glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
303-alpha-androstanediol glucuronide45 247.8UGT1A4, UGT1A7, UGT1A3, UGT1A1, UGT1A6, UGT1A5
31etiocholanolone45 247.8UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A5
32aldosterone 18-glucuronide45 247.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
33androsterone glucuronide45 247.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
341-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid246.8UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A9, UGT1A5
351-Salicylate glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
36(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
37codeine45 29 51 24 1110.7UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
38valproic acid45 51 24 119.7UGT1A4, UGT1A7, UGT1A3, UGT1A10, HBG1, UGT1A1
3925-Hydroxyvitamin D2 25-(beta-glucuronide)246.7UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4
4025-Hydroxyvitamin D2-25-glucuronide246.7UGT1A4, UGT1A7, UGT1A3, UGT1A10, UGT1A1, UGT1A6
413,17-Androstanediol glucuronide246.7UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
423-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide246.6UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
433-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide246.6UGT1A7, UGT1A4, UGT1A3, UGT1A1, UGT1A6, UGT1A5
443-Methoxy-4-hydroxyphenylglycol glucuronide246.6UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
4511-Hydroxyprogesterone 11-glucuronide246.6UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A9, UGT1A5
4611-Oxo-androsterone glucuronide246.5UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
4711-beta-hydroxyandrosterone-3-glucuronide246.4UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
482-Phenylethanol glucuronide246.4UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
492-Methoxyestrone246.3UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
502-Methoxyestrone 3-glucuronide246.1UGT1A3, UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A1

GO Terms for genes affiliated with Sickle Cell Anemia

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16Gene Ontology
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Cellular components related to Sickle Cell Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058339.6HBG1, HBB
2integral component of membraneGO:0160216.8UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4
3endoplasmic reticulum membraneGO:0057896.3UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3

Biological processes related to Sickle Cell Anemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fatty acid metabolic processGO:0459229.0UGT1A7, UGT1A9
2negative regulation of cellular glucuronidationGO:20010308.9UGT1A7, UGT1A9, UGT1A1
3drug metabolic processGO:0171448.8UGT1A1, UGT1A9, UGT1A7
4cellular glucuronidationGO:0526958.7UGT1A4, UGT1A10, UGT1A6, UGT1A1
5flavone metabolic processGO:0515528.6UGT1A7, UGT1A10, UGT1A9, UGT1A1
6flavonoid glucuronidationGO:0526968.5UGT1A1, UGT1A7, UGT1A3, UGT1A9
7xenobiotic glucuronidationGO:0526978.5UGT1A7, UGT1A3, UGT1A9, UGT1A1
8negative regulation of catalytic activityGO:0430868.5UGT1A1, UGT1A9, UGT1A7
9retinoic acid metabolic processGO:0425738.5UGT1A1, UGT1A9, UGT1A3, UGT1A7
10xenobiotic metabolic processGO:0068058.1UGT1A1, UGT1A6, UGT1A9, UGT1A4
11small molecule metabolic processGO:0442817.9HBB, UGT1A1, UGT1A6, UGT1A9, UGT1A4

Molecular functions related to Sickle Cell Anemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:0053449.8HBG1, HBB
2oxygen bindingGO:0198259.6HBB, HBG1
3protein kinase C bindingGO:0050809.5UGT1A10, UGT1A7
4enzyme inhibitor activityGO:0048578.8UGT1A1, UGT1A9, UGT1A7
5retinoic acid bindingGO:0019726.9UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A6
6enzyme bindingGO:0198996.9UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A6
7protein heterodimerization activityGO:0469826.9UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A6
8protein homodimerization activityGO:0428036.8UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A6
9glucuronosyltransferase activityGO:0150206.6UGT1A1, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A10

Products for genes affiliated with Sickle Cell Anemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sickle Cell Anemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet