SCD
MCID: SCK003
MIFTS: 82

Sickle Cell Anemia (SCD) malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases, Nephrological diseases, Reproductive diseases, Bone diseases, Endocrine diseases categories
Download this MalaCard

Summaries for Sickle Cell Anemia

About this section


Fully expand this MalaCard
MedlinePlus:33 Sickle cell anemia is a disease in which your body produces abnormally shaped red blood cells. the cells are shaped like a crescent or sickle. they don't last as long as normal, round red blood cells. this leads to anemia. the sickle cells also get stuck in blood vessels, blocking blood flow. this can cause pain and organ damage. a genetic problem causes sickle cell anemia. people with the disease are born with two sickle cell genes, one from each parent. if you only have one sickle cell gene, it's called sickle cell trait. about 1 in 12 african americans has sickle cell trait. the most common symptoms are pain and problems from anemia. anemia can make you feel tired or weak. in addition, you might have shortness of breath, dizziness, headaches, or coldness in the hands and feet. a blood test can show if you have the trait or anemia. most states test newborn babies as part of their newborn screening programs. sickle cell anemia has no widely available cure. treatments can help relieve symptoms and lessen complications. researchers are investigating new treatments such as blood and marrow stem cell transplants, gene therapy, and new medicines. nih: national heart, lung, and blood institute

MalaCards based summary: Sickle Cell Anemia, also known as hemoglobin sc disease, is related to alpha thalassemia and beta thalassemia, and has symptoms including An important gene associated with Sickle Cell Anemia is HBB (hemoglobin, beta), and among its related pathways are thyroid hormone metabolism II (via conjugation and/or degradation) and AHR Pathway. The drug sodium phenylbutyrate and the compounds uridine diphosphate and imipramine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and heart.

NIH Rare Diseases:42 Sickle cell anemia is a disease in which the body produces abnormally shaped red blood cells that have a crescent or sickle shape. these cells do not last as long as normal, round, red blood cells, which leads to anemia (low number of red blood cells). the sickle cells also get stuck in blood vessels, blocking blood flow. signs and symptoms of sickle cell disease usually begin in early childhood and may include anemia, repeated infections, and periodic episodes of pain (called crises). this condition is caused by mutations in the hbb gene and is inherited in an autosomal recessive pattern. treatment typically focuses on controlling symptoms and may include pain medicines during crises; hydroxyurea to reduce the number of pain episodes; antibiotics and vaccines to prevent bacterial infections; and blood transfusions. last updated: 11/10/2011

Wikipedia:65 Sickle-cell disease (SCD), or sickle-cell anaemia (SCA) or sometimes drepanocytosis, is a hereditary... more...

Description from OMIM:46 603903

Aliases & Classifications for Sickle Cell Anemia

About this section
Sources:
30LifeMap Discovery®, 8Disease Ontology, 9diseasecard, 65Wikipedia, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 48Orphanet, 33MedlinePlus, 62UMLS, 20GeneTests, 22GTR, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Sickle Cell Anemia, Aliases & Descriptions:

Name: Sickle Cell Anemia 30 8 9 65 42 46 10 48 33
Hemoglobin Sc Disease 8 42 20 62
Hemoglobin S Disease 65 42 20
Sickle Cell Disease 42 48 62
Hb S Disease 65 22 62
Sickle-Cell/hb-C Disease Without Crisis 8 62
Sickling Disorder Due to Hemoglobin S 42 62
Hb-Ss Disease Without Crisis 8 62
Drepanocytosis 8 62
 
Hbs Disease 42 62
Haemoglobin S Disease Without Crisis 62
Hemoglobin S Disease Without Crisis 8
Haemoglobin S Disease 62
Anemia, Sickle Cell 62
Hb-S/hb-C Disease 8
Herrick's Anemia 65
Hb Sc Disease 8
Scd 65


Classifications:



Characteristics (Orphanet epidemiological data):

48
sickle cell anemia:
Inheritance: Autosomal recessive; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Adult


External Ids:

Disease Ontology8 DOID:10923
ICD9CM27 282.6, 282.60
MeSH34 D000755
OMIM46 603903
NCIt39 C34383
MESH via Orphanet35 D000755
ICD10 via Orphanet26 D57.0, D57.1, D57.2
UMLS via Orphanet63 C0002895
ICD1025 D57.0, D57.1

Related Diseases for Sickle Cell Anemia

About this section

Graphical network of the top 20 diseases related to Sickle Cell Anemia:



Diseases related to sickle cell anemia

Symptoms for Sickle Cell Anemia

About this section


Clinical features from OMIM:

603903

HPO human phenotypes related to Sickle Cell Anemia:

(show all 11)
id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 retinopathy HP:0000488
3 hematuria HP:0000790
4 jaundice HP:0000952
5 cholelithiasis HP:0001081
6 cardiomegaly HP:0001640
7 splenomegaly HP:0001744
8 hemolytic anemia HP:0001878
9 hepatomegaly HP:0002240
10 increased red cell sickling tendency HP:0008346
11 priapism HP:0200023

Drugs & Therapeutics for Sickle Cell Anemia

About this section

Drug clinical trials:

Search ClinicalTrials for Sickle Cell Anemia

Search NIH Clinical Center for Sickle Cell Anemia

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Sickle Cell Anemia cell therapies at LifeMap Discovery.

Genetic Tests for Sickle Cell Anemia

About this section

Genetic tests related to Sickle Cell Anemia:

id Genetic test Affiliating Genes
1 Hemoglobin Sc20 HBB
2 Hemoglobin Ss20 HBB
3 Hb Ss Disease22

Anatomical Context for Sickle Cell Anemia

About this section

MalaCards organs/tissues related to Sickle Cell Anemia:

32
Bone, Testes, Heart, Lung, Endothelial, Bone marrow, Liver, Spleen, Brain, Neutrophil, Kidney, Spinal cord, Colon, Pancreas, Skin, Placenta, Myeloid, Monocytes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Sickle Cell Anemia:
id TissueAnatomical CompartmentCell Relevance
1 BloodPeripheral BloodErythrocytes Potential therapeutic candidate, affected by disease

Animal Models for Sickle Cell Anemia or affiliated genes

About this section

Publications for Sickle Cell Anemia

About this section

Articles related to Sickle Cell Anemia:

(show top 50)    (show all 644)
idTitleAuthorsYear
1
TNF-I+, IFN-I^, IL-10, and IL-4 levels were elevated in a murine model of human sickle cell anemia maintained on a high protein/calorie diet. (24281564)
2014
2
Bacteremia Caused by Microbacterium binotii in a Patient with Sickle Cell Anemia. (24197889)
2014
3
Association of alpha-thalassemia, TNF-alpha (-308G>A) and VCAM-1 (c.1238G>C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia. (25175566)
2014
4
Adrenal myelolipoma, cholelithiasis and calcified spleen: retrospective diagnosis of sickle cell anemia using a novel triad of abdominal imaging findings. (25053687)
2014
5
Molecular analysis and association with clinical and laboratory manifestations in children with sickle cell anemia. (25305165)
2014
6
Effect of extended-release niacin on serum lipids and on endothelial function in adults with sickle cell anemia and low high-density lipoprotein cholesterol levels. (24035168)
2013
7
Malnutrition in Sickle Cell Anemia: Implications for Infection, Growth, and Maturation. (24312698)
2013
8
Spectral detection of sickle cell anemia and thalassemia. (24284096)
2013
9
Hydroxyurea treatment decreases glomerular hyperfiltration in children with sickle cell anemia. (23255310)
2013
10
Transcranial Doppler velocity and brain MRI/MRA changes in children with sickle cell anemia on chronic transfusions to prevent primary stroke. (23625812)
2013
11
Severe painful vaso-occlusive crises and mortality in a contemporary adult sickle cell anemia cohort study. (24224021)
2013
12
Pain and other non-neurological adverse events in children with sickle cell anemia and previous stroke who received hydroxyurea and phlebotomy or chronic transfusions and chelation: results from the SWiTCH clinical trial. (23861242)
2013
13
Tissue factor and thrombin in sickle cell anemia. (22398014)
2012
14
Zoster myelitis in sickle cell anemia. (22246022)
2012
15
Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans. (22139998)
2012
16
Advantages of isovolemic hemodilution-red cell exchange therapy to prevent recurrent stroke in sickle cell anemia patients. (21786315)
2011
17
Spontaneous epidural hematoma: a rare complication of sickle cell anemia. (21483142)
2011
18
Gated myocardial perfusion scintigraphy in children with sickle cell anemia: correlation with echocardiography. (21458111)
2011
19
Proteinuria among adult sickle cell anemia patients in Nigeria. (21311153)
2011
20
Sickle cell anemia pathophysiology: back to the data. (21264895)
2011
21
Determination of I^ haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil. (21931513)
2011
22
Homozygous sickle cell anemia and secondary complications: a case study. (21657139)
2011
23
Tibial chronic osteomyelitis due to Propionibacterium acnes in a patient with sickle cell anemia. (19913448)
2010
24
Atrial septal defect closure on cardiopulmonary bypass in a sickle cell anemia: role of hydroxyurea and partial exchange transfusion. (20442545)
2010
25
Safety of pegylated interferon and ribavirin therapy for chronic hepatitis C in patients with sickle cell anemia. (21160993)
2010
26
Sickle cell anemia and vascular dysfunction: the nitric oxide connection. (20578237)
2010
27
Neurocognitive complications of sickle cell anemia in adults. (20460628)
2010
28
Pulmonary thrombi are not detected by 3D magnetic resonance angiography in adults with sickle cell anemia and an elevated triscuspid regurgitant jet velocity. (19743468)
2009
29
Human platelet alloantigens (HPA) 1, HPA2, HPA3, HPA4, and HPA5 polymorphisms in sickle cell anemia patients with vaso-occlusive crisis. (19702628)
2009
30
Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C disease. (19644138)
2009
31
The prevalence of sickle cell anemia in Saudi children and adolescents. A community-based survey. (19271087)
2009
32
Usefulness and limitations of Bayesian network model as a mortality risk assessment tool in sickle cell anemia. (19338040)
2009
33
Acute splenic sequestration in a cohort of children with sickle cell anemia. (19319450)
2009
34
Prenatal diagnosis of sickle cell anemia and beta-thalassemia in southern Turkey. (19065329)
2008
35
A simple index using age, hemoglobin, and aspartate transaminase predicts increased intracerebral blood velocity as measured by transcranial Doppler scanning in children with sickle cell anemia. (18490379)
2008
36
Chronic multifocal osteomyelitis due to Clostridium difficile in an adolescent with sickle cell anemia. (18724265)
2008
37
Cytokine concentrations in bone marrow of stable sickle cell anemia patients. (17362693)
2007
38
Airway hyperresponsiveness and acute chest syndrome in children with sickle cell anemia. (17262858)
2007
39
Gene interactions and stroke risk in children with sickle cell anemia. (14615367)
2004
40
Immunotactoid glomerulopathy in sickle cell anemia. (11198611)
2001
41
Intracranial hemorrhage associated with splenic sequestration in a Saudi child with sickle cell anemia: case report and review of the literature. (17264555)
2001
42
Growth hormone and insulin-like growth factor I axis and growth of children with different sickle cell anemia haplotypes. (11563770)
2001
43
Effect of alpha-thalassemia and beta-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil. (8892730)
1996
44
Cardiovascular function during rest and exercise in patients with sickle-cell anemia and coexisting alpha thalassemia-2. (8638648)
1996
45
Smoking is a factor in causing acute chest syndrome in sickle cell anemia. (1578502)
1992
46
Ultrasonography: hepatic vein thrombosis in sickle cell anemia. (7114404)
1982
47
Outcome of pregnancy in sickle cell anemia and sickle cell-hemoglobin C disease. An analysis of 181 pregnancies in 98 patients, and a review of the literature. (7416213)
1980
48
Sickle cell trait/hereditary persistence of fetal hemoglobin trait. Misdiagnosis as sickle cell anemia by newborn screening. (517474)
1979
49
HYPERSPLENISM IN SICKLE CELL ANEMIA. (14170620)
1964
50
Pregnancy with sickle cell anemia and placenta accreta. (14942979)
1952

Variations for Sickle Cell Anemia

About this section

Clinvar genetic disease variations for Sickle Cell Anemia:

6
id Gene Name Type Significance SNP ID Assembly Location
1HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232
2HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232
3HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232
4HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232
5HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232
6HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232
7HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232
8HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232
9HBBNM_000518.4(HBB): c.20A> T (p.Glu7Val)single nucleotide variantPathogenicrs334GRCh37Chr 11, 5248232: 5248232

Expression for genes affiliated with Sickle Cell Anemia

About this section
Expression patterns in normal tissues for genes affiliated with Sickle Cell Anemia

Search GEO for disease gene expression data for Sickle Cell Anemia.

Pathways for genes affiliated with Sickle Cell Anemia

About this section

Pathways related to Sickle Cell Anemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6UGT1A10, UGT1A3
2
Show member pathways
AhR pathway37
9.6UGT1A6, UGT1A1
3
Show member pathways
bupropion degradation37
methylglyoxal degradation III37
nicotine degradation III37
nicotine degradation IV37
9.4UGT1A4, UGT1A10
4
Show member pathways
Nicotine metabolism37
9.0UGT1A4, UGT1A9
58.8UGT1A1, UGT1A6, UGT1A9
6
Show member pathways
8.4UGT1A3, UGT1A1, UGT1A9, UGT1A10
7
Show member pathways
7.7UGT1A9, UGT1A3, UGT1A4, UGT1A6, UGT1A1
87.7UGT1A4, UGT1A1, UGT1A6, UGT1A9, UGT1A3
97.6UGT1A6, UGT1A10, UGT1A3, UGT1A4, UGT1A9
10
Show member pathways
6.7UGT1A1, UGT1A6, UGT1A4, UGT1A7, UGT1A3, UGT1A9
11
Show member pathways
6.4UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7
12
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
6.4UGT1A9, UGT1A5, UGT1A6, UGT1A1, UGT1A10, UGT1A3
13
Show member pathways
6.4UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5
14
Show member pathways
6.4UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5
15
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
6.4UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5
16
Show member pathways
6.4UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5
17
Show member pathways
6.2UGT1A3, UGT1A4, UGT1A10, UGT1A7, UGT1A5, UGT1A6

Compounds for genes affiliated with Sickle Cell Anemia

About this section

Compounds related to Sickle Cell Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 149)
idCompoundScoreTop Affiliating Genes
1uridine diphosphate447.1UGT1A4, UGT1A7, UGT1A3, UGT1A10, UGT1A1, UGT1A6
2imipramine44 28 50 24 1111.0UGT1A1, UGT1A6, UGT1A9, UGT1A10, UGT1A3, UGT1A4
3Deoxycholic acid 3-glucuronide246.9UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A5
4Dopamine glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
5Glycochenodeoxycholic acid 3-glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
6Dextrorphan O-glucuronide246.9UGT1A7, UGT1A4, UGT1A1, UGT1A6, UGT1A5, UGT1A9
7Isovalerylglucuronide246.9UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4
8Ketoprofen glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
9Inodxyl glucuronide246.9UGT1A7, UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10
10Cholesterol glucuronide246.9UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4
11Cholic acid glucuronide246.9UGT1A4, UGT1A7, UGT1A3, UGT1A10, UGT1A1, UGT1A6
12Cortolone-3-glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
13Cotinineglucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
14Dehydroepiandrosterone 3-glucuronide246.9UGT1A7, UGT1A4, UGT1A3, UGT1A1, UGT1A6, UGT1A5
15Dehydroisoandrosterone 3-glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
16trans-3-Hydroxycotinine glucuronide246.9UGT1A7, UGT1A4, UGT1A1, UGT1A6, UGT1A5, UGT1A9
17Tyramine glucuronide246.9UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A9, UGT1A5
18Uridine 5'-diphosphate246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
19Triiodothyronine glucuronide246.9UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
20Uridine diphosphate glucuronic acid246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
21Valproic acid glucuronide246.8UGT1A3, UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A1
22Vitamin D2 3-glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
23Nicotine glucuronide246.8UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7
24Octanoylglucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
25Lithocholate 3-O-glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
26Phenethylamine glucuronide246.8UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A5
27Palmitoyl glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
28(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)246.8UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A9, UGT1A1
291-Salicylate glucuronide246.8UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4
3011-beta-hydroxyandrosterone-3-glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
311-(alpha-Methyl-4-(2-methylpropyl)benzeneacetate)-beta-D-Glucopyranuronic acid246.8UGT1A7, UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10
3211-Oxo-androsterone glucuronide246.8UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7
3315-hydroxynorandrostene-3,17-dione glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
3411-Hydroxyprogesterone 11-glucuronide246.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
35estrone44 28 24 119.8UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
36valproic acid44 50 24 119.7HBG1, UGT1A1, UGT1A6, UGT1A9, UGT1A10, UGT1A3
372-methoxyestradiol44 61 248.7UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
38codeine44 28 50 24 1110.7UGT1A7, UGT1A4, UGT1A1, UGT1A6, UGT1A5, UGT1A9
393-alpha,20-alpha-dihydroxy-5-beta-pregnane 3-glucuronide246.7UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
403-alpha-hydroxy-5-alpha-androstane-17-one 3-D-glucuronide246.7UGT1A3, UGT1A4, UGT1A7, UGT1A10, UGT1A9, UGT1A1
413-Methoxy-4-hydroxyphenylglycol glucuronide246.7UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
424-Hydroxyandrostenedione glucuronide246.6UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
435-alpha-Dihydrotestosterone glucuronide246.6UGT1A4, UGT1A7, UGT1A3, UGT1A10, UGT1A1, UGT1A6
445-Hydroxy-6-methoxyindole glucuronide246.6UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
453,17-Androstanediol glucuronide246.6UGT1A7, UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10
4617-alpha-estradiol-3-glucuronide246.5UGT1A9, UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A5
4717-beta-estradiol glucuronide246.4UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
4825-Hydroxyvitamin D2 25-(beta-glucuronide)246.4UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
4916-alpha,17-beta-estriol 17-beta-D-glucuronide246.3UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3
5025-Hydroxyvitamin D2-25-glucuronide246.1UGT1A10, UGT1A3, UGT1A4, UGT1A7, UGT1A9, UGT1A5

GO Terms for genes affiliated with Sickle Cell Anemia

About this section

Cellular components related to Sickle Cell Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058339.6HBG1, HBB
2integral component of membraneGO:0160216.8UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3, UGT1A4
3endoplasmic reticulum membraneGO:0057896.3UGT1A1, UGT1A6, UGT1A5, UGT1A9, UGT1A10, UGT1A3

Biological processes related to Sickle Cell Anemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fatty acid metabolic processGO:0459229.0UGT1A7, UGT1A9
2negative regulation of cellular glucuronidationGO:20010308.9UGT1A9, UGT1A1, UGT1A7
3drug metabolic processGO:0171448.8UGT1A1, UGT1A9, UGT1A7
4cellular glucuronidationGO:0526958.7UGT1A6, UGT1A4, UGT1A10, UGT1A1
5flavone metabolic processGO:0515528.6UGT1A1, UGT1A9, UGT1A10, UGT1A7
6xenobiotic glucuronidationGO:0526978.5UGT1A1, UGT1A9, UGT1A3, UGT1A7
7flavonoid glucuronidationGO:0526968.5UGT1A3, UGT1A9, UGT1A1, UGT1A7
8negative regulation of catalytic activityGO:0430868.5UGT1A9, UGT1A1, UGT1A7
9retinoic acid metabolic processGO:0425738.5UGT1A7, UGT1A3, UGT1A9, UGT1A1
10xenobiotic metabolic processGO:0068058.1UGT1A1, UGT1A6, UGT1A9, UGT1A4
11small molecule metabolic processGO:0442817.9UGT1A1, HBB, UGT1A6, UGT1A9, UGT1A4

Molecular functions related to Sickle Cell Anemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:0053449.8HBB, HBG1
2oxygen bindingGO:0198259.6HBG1, HBB
3protein kinase C bindingGO:0050809.5UGT1A10, UGT1A7
4enzyme inhibitor activityGO:0048578.8UGT1A1, UGT1A9, UGT1A7
5retinoic acid bindingGO:0019726.9UGT1A1, UGT1A7, UGT1A6, UGT1A9, UGT1A10, UGT1A3
6enzyme bindingGO:0198996.9UGT1A3, UGT1A7, UGT1A10, UGT1A1, UGT1A4, UGT1A9
7protein heterodimerization activityGO:0469826.9UGT1A7, UGT1A1, UGT1A6, UGT1A9, UGT1A10, UGT1A3
8protein homodimerization activityGO:0428036.8UGT1A7, UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A6
9glucuronosyltransferase activityGO:0150206.6UGT1A4, UGT1A3, UGT1A10, UGT1A9, UGT1A5, UGT1A6

Products for genes affiliated with Sickle Cell Anemia

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Sickle Cell Anemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet