MCID: SCK021
MIFTS: 12

Sickle Cell - Beta-Thalassemia Disease malady

Blood category

Summaries for Sickle Cell - Beta-Thalassemia Disease

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33MalaCards
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MalaCards: Sickle Cell - Beta-Thalassemia Disease, also known as hbs - beta-thalassemia, is related to hemoglobin sickle-beta thalassemia and hemoglobin s beta-thalassemia. An important gene associated with Sickle Cell - Beta-Thalassemia Disease is HBB (hemoglobin, beta). Affiliated tissues include b cells.

Aliases & Classifications for Sickle Cell - Beta-Thalassemia Disease

Sources:
49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
sickle cell - beta-thalassemia disease:
Inheritance: Autosomal recessive; Age of onset: Variable


Aliases & Descriptions:

sickle cell - beta-thalassemia disease 49
hbs - beta-thalassemia 49


External Ids:

ICD10 via Orphanet26 D57.2

Related Diseases for Sickle Cell - Beta-Thalassemia Disease

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17GeneCards, 18GeneDecks
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Diseases related to Sickle Cell - Beta-Thalassemia Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1hemoglobin sickle-beta thalassemia10.3
2hemoglobin s beta-thalassemia10.3
3hemoglobin c - beta-thalassemia10.3

Clinical Features for Sickle Cell - Beta-Thalassemia Disease

Drugs & Therapeutics for Sickle Cell - Beta-Thalassemia Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sickle Cell - Beta-Thalassemia Disease

Anatomical Context for Sickle Cell - Beta-Thalassemia Disease

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33MalaCards
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MalaCards organs/tissues related to Sickle Cell - Beta-Thalassemia Disease:

33
B cells

Animal Models for Sickle Cell - Beta-Thalassemia Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Sickle Cell - Beta-Thalassemia Disease

Sources:
51PubMed
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Articles related to Sickle Cell - Beta-Thalassemia Disease:

(show all 15)
idTitleAuthorsYear
1
Non-invasive prenatal diagnosis of beta-thalassemia and sickle-cell disease using pyrophosphorolysis-activated polymerization and melting curve analysis. (22517437)
2012
2
Epidural anesthesia for laparoscopic cholecystectomy in a patient with sickle cell anemia, beta thalassemia, and Crohn's disease -A case report-. (23115690)
2012
3
Differences in response to fetal hemoglobin induction therapy in beta-thalassemia and sickle cell disease. (19346141)
2009
4
First case of gamma-thalassemia in association with a betaS allele: a pitfall in the neonatal screening for sickle cell disease. (18728021)
2008
5
Acute splenic sequestration crisis (ASSC) in an adult patient with beta-thalassemia sickle cell disease: a life-threatening complication. (18084762)
2008
6
Beta-globin gene cluster haplotypes and alpha-thalassemia in sickle cell disease patients from Trinidad. (18257074)
2008
7
Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression. (17613866)
2007
8
Increased procoagulant activity of red blood cells from patients with homozygous sickle cell disease and beta-thalassemia. (8883264)
1996
9
Butyrate in the treatment of sickle cell disease and beta-thalassemia. (9371980)
1995
10
Beta-globin gene cluster haplotype and alpha-thalassemia do not correlate with the acute clinical manifestations of sickle cell disease in children. (8400306)
1993
11
The hand-foot syndrome in sickle cell beta-thalassemia disease. (578226)
1977
12
Symptomatic joint effusions in sickle cell-beta-thalassemia disease. Report of a case. (946491)
1976
13
Joint effusions in sickle cell-beta-thalassemia disease. (1036549)
1976
14
Roentgenographic and clinical appraisal of sickle cell beta-thalassemia disease. (4268239)
1973
15
THE FIRST OBSERVATION OF HOMOZYGOUS HEMOGLOBIN S-ALPHA THALASSEMIA DISEASE AND TWO TYPES OF SICKLE CELL THALASSEMIA DISEASE: (A) SICKLE CELL-ALPHA THALASSEMIA DISEASE, (B) SICKLE CELL-BETA THALASSEMIA DISEASE. (14084634)
1963

Genetic Variations for Sickle Cell - Beta-Thalassemia Disease

Expression for genes affiliated with Sickle Cell - Beta-Thalassemia Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sickle Cell - Beta-Thalassemia Disease

Search GEO for disease gene expression data for Sickle Cell - Beta-Thalassemia Disease.

Pathways for genes affiliated with Sickle Cell - Beta-Thalassemia Disease

Compounds for genes affiliated with Sickle Cell - Beta-Thalassemia Disease

GO Terms for genes affiliated with Sickle Cell - Beta-Thalassemia Disease

Products for genes affiliated with Sickle Cell - Beta-Thalassemia Disease

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Sources for Sickle Cell - Beta-Thalassemia Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet