MCID: SCK005
MIFTS: 51

Sickle Cell Disease

Categories: Immune diseases, Blood diseases, Genetic diseases

Aliases & Classifications for Sickle Cell Disease

MalaCards integrated aliases for Sickle Cell Disease:

Name: Sickle Cell Disease 23 24 25 52 3
Sickling Disorder Due to Hemoglobin S 25
Sickle Cell Disorders 25
Hemoglobin S Disease 25
Anemia, Sickle Cell 69
Hbs Disease 25
Scd 25

Classifications:



External Ids:

ICD10 33 D57

Summaries for Sickle Cell Disease

Genetics Home Reference : 25 Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

MalaCards based summary : Sickle Cell Disease, also known as sickling disorder due to hemoglobin s, is related to malaria and hepatitis, and has symptoms including abdominal pain, angina pectoris and chest pain. An important gene associated with Sickle Cell Disease is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Glucose / Energy Metabolism and Factors involved in megakaryocyte development and platelet production. The drugs Peginterferon alfa-2a and Peginterferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related phenotypes are Increased shRNA abundance and cardiovascular system

Wikipedia : 72 Sickle-cell disease (SCD) is a group of blood disorders typically inherited from a person\'s parents.... more...

GeneReviews: NBK1377

Related Diseases for Sickle Cell Disease

Diseases related to Sickle Cell Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
id Related Disease Score Top Affiliating Genes
1 malaria 30.5 EPO G6PD HBA2 HBB SELP VCAM1
2 hepatitis 30.2 G6PD HBA2 HBB
3 pyruvate kinase deficiency 29.0 EPO G6PD HBA2 HBG2
4 sickle cell anemia 28.8 BCL11A EPO G6PD HBA2 HBB HBD
5 hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 12.0
6 sickle cell disease associated with an other hemoglobin anomaly 11.9
7 corneal dystrophy, schnyder type 11.5
8 acute chest syndrome 11.4
9 superior semicircular canal dehiscence syndrome 11.4
10 hemoglobinopathy 11.3
11 sickle beta thalassemia 11.1
12 obesity 11.1
13 diabetes mellitus, noninsulin-dependent 11.0
14 reye syndrome 11.0
15 spondylocheirodysplasia, ehlers-danlos syndrome-like 10.9
16 moyamoya disease 10.8
17 chronic laryngitis 10.8 BCAM HBB
18 chronic inflammatory demyelinating polyneuritis 10.6 EPO HBB
19 methylmalonic acidemia with homocystinuria 10.6 HBA2 HBB
20 gaba-transaminase deficiency 10.6 HBA2 HBB
21 distal arthrogryposis 10.5 HBA2 HBB
22 disseminated intravascular coagulation 10.5 EPO HBA2
23 timothy syndrome type 2 10.4 EPO HBA2 HBB
24 thalassemia 10.4
25 priapism 10.3
26 nephrotic syndrome 14 10.3 G6PD HBA2 HBB
27 scleredema adultorum 10.3 SELP VCAM1
28 angiokeratoma 10.3 SELP VCAM1
29 splenic sequestration 10.3
30 split hand/foot malformation x-linked 10.3 EPO KCNN4
31 acute radiation syndrome 10.3 G6PD HBG2
32 cryptosporidiosis 10.3 PGF SELP
33 peripheral vascular disease 10.2 G6PD HBG2
34 renal artery disease 10.2 G6PD UGT1A1
35 renovascular hypertension 10.2 HBB VCAM1
36 tinf2-related dyskeratosis congenita 10.2 HBA2 HBB
37 adult-onset distal myopathy due to vcp mutation 10.2 HBB HBD
38 cat-scratch disease 10.2 EPO G6PD HBA2
39 bartholin's gland adenoma 10.2 HBB HBD
40 hepatitis b reinfection following liver transplantation 10.2 HBB HBG1 HBG2
41 idiopathic progressive polyneuropathy 10.2 PGF VCAM1
42 pulmonary hypertension 10.2
43 endotheliitis 10.2
44 hepatic infarction 10.2 HBB HBD
45 glucosephosphate dehydrogenase deficiency 10.1 HBB HBD
46 central epithelioid sarcoma 10.1 HBB HBD
47 algoneurodystrophy 10.1 HBA2 HBB
48 avascular necrosis of the femoral head 10.1
49 cholelithiasis 10.1
50 cerebritis 10.1

Graphical network of the top 20 diseases related to Sickle Cell Disease:



Diseases related to Sickle Cell Disease

Symptoms & Phenotypes for Sickle Cell Disease

UMLS symptoms related to Sickle Cell Disease:


abdominal pain, angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Sickle Cell Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 EPO G6PD HBD HBG2

MGI Mouse Phenotypes related to Sickle Cell Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 VCAM1 BCAM EPO G6PD KCNN4 PGF

Drugs & Therapeutics for Sickle Cell Disease

Drugs for Sickle Cell Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 386)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
2
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
3
Ribavirin Approved Phase 4 36791-04-5 37542
4
Hydroxyurea Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 127-07-1 3657
5
Deferasirox Approved, Investigational Phase 4,Phase 2,Phase 3 201530-41-8 5493381
6
Deferoxamine Approved, Investigational Phase 4,Phase 2,Phase 3 70-51-9 2973
7
Iron Approved Phase 4,Phase 2,Phase 3,Phase 1 7439-89-6 23925
8
Deferiprone Approved Phase 4,Phase 2,Phase 3,Phase 1 30652-11-0 2972
9
Proguanil Approved Phase 4,Phase 1,Phase 2 500-92-5 4923
10
Hydromorphone Approved, Illicit Phase 4,Phase 3,Phase 2 466-99-9 5284570
11
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 57-27-2 5288826
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2 437-38-7 3345
13
Amodiaquine Approved Phase 4,Phase 1,Phase 2 86-42-0 2165
14
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 58-14-0 4993
15
Sulfadoxine Approved Phase 4,Phase 3,Phase 1,Phase 2 2447-57-6 17134
16
Codeine Approved, Illicit Phase 4,Phase 1,Phase 2 76-57-3 5284371
17
Guaifenesin Approved, Vet_approved Phase 4,Phase 1,Phase 2 93-14-1 3516
18
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
19
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2 6740-88-1 3821
20
Desogestrel Approved Phase 4 54024-22-5 40973
21
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
22
Heroin Approved, Illicit Phase 4 561-27-3 5462328
23
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
24
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 1 67-97-0 6221 10883523 5280795
25
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 1 50-14-6 5280793
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 1406-16-2
27 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
29 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Interferon-alpha Phase 4
31 interferons Phase 4
32 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
33 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Calcium, Dietary Phase 4,Phase 2,Phase 3,Phase 1
35 Chelating Agents Phase 4,Phase 2,Phase 3,Phase 1
36 Iron Chelating Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Liver Extracts Phase 4,Phase 2,Phase 3,Phase 1
38 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
39 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
40 Antimalarials Phase 4,Phase 3,Phase 2,Phase 1
41 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Bone Density Conservation Agents Phase 4,Phase 2,Phase 1
44 Ergocalciferols Phase 4,Phase 2,Phase 1
45 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
46 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Vaccines Phase 4,Phase 3,Phase 2,Early Phase 1
48 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Analgesics, Opioid Phase 4,Phase 3,Phase 1,Phase 2
50 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 598)

id Name Status NCT ID Phase Drugs
1 Interferon and Ribavirin Treatment in Patients With Hemoglobinopathies Unknown status NCT00887081 Phase 4 PEG-IFN alpha2a or PEG-IFN alpha2b and Ribavirin
2 Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease Completed NCT02222246 Phase 4 Hydromorphone (Standardized, weight-based dosing);Morphine Sulfate (Standardized, weight-based dosing);Hydromorphone (Patient Specific dosing);Morphine Sulfate (Patient Specific dosing)
3 Future of Spermatogenesis in Men With Sickle Cell Disease Medically Treated Completed NCT01609192 Phase 4 Hydrea® (hydroxyurea )
4 Evaluation of the Impact of Renal Function on the Pharmacokinetics of SIKLOS ® (DARH) Completed NCT02522104 Phase 4 Siklos
5 Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis Completed NCT01482091 Phase 4 Fentanyl Citrate;Normal Saline
6 Pilot Study for Patients With Poor Response to Deferasirox Completed NCT00749515 Phase 4 Deferoxamine;Deferasirox
7 Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias Recruiting NCT02041299 Phase 4 Deferiprone;Deferoxamine
8 Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent Transfusions Recruiting NCT02731157 Phase 4 Rejuvesol
9 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
10 Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment Active, not recruiting NCT02149537 Phase 4 hydroxyurea
11 Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias Enrolling by invitation NCT02443545 Phase 4 Deferiprone
12 Mobile-Directly Observed Therapy on Adherence to Hydroxyurea Enrolling by invitation NCT02844673 Phase 4 Hydroxyurea
13 Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Not yet recruiting NCT03178643 Phase 4 Proguanil Oral Tablet;Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ);Dihydroartemisinin-Piperaquine (DP)
14 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
15 Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine Terminated NCT00880373 Phase 4 Ibuprofen;Placebo;Diamorphine or Morphine
16 Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Disease Terminated NCT00252122 Phase 4 Ketamine
17 Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease Terminated NCT00115336 Phase 4 Intravenous Ketorolac;Ibuprofen
18 Immunogenicity and Safety Study of Pneumococcal 7-Valent Conjugate Vaccine in Sickle Cell Disease Infants. Terminated NCT00368186 Phase 4
19 Assessment of Opioid Analgesia in Sickle Cell Withdrawn NCT00513864 Phase 4 Dextromethorphan;Codeine;Morphine
20 Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil Withdrawn NCT00937144 Phase 4 Viagra (Sildenafil);placebo
21 Transfusion Alternatives Pre-Operatively in Sickle Cell Disease (TAPS) Unknown status NCT00512577 Phase 3
22 Long-Term Effects of Hydroxyurea in Children With Sickle Cell Anemia (The BABY HUG Follow-up Study) Unknown status NCT00890396 Phase 3
23 Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload Unknown status NCT01511848 Phase 2, Phase 3 DFP (ferriprox) and deferasirox (ICL 670);DFP, DFO
24 Evaluation of the Lung Capillary Blood Volume in Children With Sickle Cell Disease Completed NCT00560261 Phase 3
25 Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC) Completed NCT01737814 Phase 3 Saline;MST-188
26 L-Arginine and Sickle Cell Disease Completed NCT01142219 Phase 3 L-arginine;Placebo
27 Hypnosis to Manage Pain and Symptoms in Patients With Sickle Cell Disease Completed NCT00393250 Phase 3
28 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo
29 Steroid Treatment for Sickle Cell Pain Crisis Completed NCT00263562 Phase 3 Methylprednisolone plus prednisone taper
30 A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia Completed NCT01179217 Phase 3 L-glutamine;Placebo
31 Evaluation of Repeat Administration of Purified Poloxamer 188 Completed NCT02449616 Phase 3 MST-188
32 Study Evaluating 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Children With Sickle Cell Disease Completed NCT00918580 Phase 3
33 Phase III Randomized Study of Poloxamer 188 for Vaso-Occlusive Crisis of Sickle Cell Disease Completed NCT00004408 Phase 3 poloxamer 188
34 Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia Completed NCT00399074 Phase 3 sulfadoxine pyrimethamine
35 Ameliorating Attention Problems in Children With Sickle Cell Disease (SCD) Completed NCT01411280 Phase 3 methylphenidate
36 Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis Completed NCT01197417 Phase 2, Phase 3 Intravenous Magnesium Sulfate;Normal Saline Placebo
37 Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH) Completed NCT00000586 Phase 3 hydroxyurea
38 Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia Completed NCT00006400 Phase 3 Hydroxyurea;Placebo
39 Penicillin Prophylaxis in Sickle Cell Disease (PROPS) Completed NCT00000585 Phase 3 penicillin
40 Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study) Completed NCT00748423 Phase 2, Phase 3 Nitric Oxide;Placebo
41 Stroke Prevention in Sickle Cell Anemia (STOP 1) Completed NCT00000592 Phase 3
42 Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial Completed NCT00072761 Phase 3
43 Mobilization and Handling of Stem Cells for Transplant From Healthy Volunteers With Sickle Cell Trait Completed NCT00005782 Phase 3 Granulocyte colony-stimulating factor
44 Stroke Prevention in Sickle Cell Anemia (STOP 2) Completed NCT00006182 Phase 3
45 MAST - Magnesium for Sickle Cell Acute Crisis in Children Completed NCT00313963 Phase 3 Magnesium Sulfate;Normal Saline
46 Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload Completed NCT00235391 Phase 3 Deferasirox
47 A Trial of Hydroxyurea in Spinal Muscular Atrophy Completed NCT00485511 Phase 2, Phase 3 Hydroxyurea
48 Immunization of Children Between 8 Weeks and 2 Years of Age With GSK Pneumococcal Vaccine GSK1024850A Completed NCT01175083 Phase 3
49 Oxygen Therapy and Pregnancy in Sickle Cell Disease Recruiting NCT02813850 Phase 3
50 Study to Evaluate the Effect of GBT440 Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE) Recruiting NCT03036813 Phase 3 GBT440

Search NIH Clinical Center for Sickle Cell Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Sickle Cell Disease

Genetic tests related to Sickle Cell Disease:

id Genetic test Affiliating Genes
1 Sickle Cell Disease 24 HBB

Anatomical Context for Sickle Cell Disease

MalaCards organs/tissues related to Sickle Cell Disease:

39
Bone, Bone Marrow, Kidney, Endothelial, Lung, Liver, Brain

Publications for Sickle Cell Disease

Articles related to Sickle Cell Disease:

(show top 50) (show all 1298)
id Title Authors Year
1
Bilateral Subperiosteal Hematoma and Orbital Compression Syndrome in Sickle Cell Disease. ( 28938324 )
2017
2
Cholelithiasis and its complications in sickle cell disease in a university hospital. ( 28270342 )
2017
3
Daily Opioid Use Fluctuates as a Function of Pain, Catastrophizing, and Affect in Patients with Sickle Cell Disease: an Electronic Daily Diary Analysis. ( 28943232 )
2017
4
Desire for parenthood and reproductive health knowledge in adolescents and young adults with sickle cell disease and their caregivers. ( 28944997 )
2017
5
Distinct patterns of response to transfusion therapy for different chronic complications of sickle cell disease: A useful insight. ( 28919009 )
2017
6
Association of Guideline-Adherent Antibiotic Treatment With Readmission of Children With Sickle Cell Disease Hospitalized With Acute Chest Syndrome. ( 28892533 )
2017
7
Do Alpha Thalassemia, Fetal Hemoglobin, and the UGT1A1 Polymorphism have an Influence on Serum Bilirubin Levels and Cholelithiasis in Patients with Sickle Cell Disease? ( 28567595 )
2017
8
Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs via AKAPs Is Revealed by AFM. ( 28076805 )
2017
9
Innovative PCR without DNA extraction for African sickle cell disease diagnosis. ( 28929945 )
2017
10
Retinal microcirculation imaging in sickle cell disease patients. ( 28943261 )
2017
11
Gene therapy: Erasing sickle-cell disease. ( 28953858 )
2017
12
Eccrine Chromhidrosis in an Adolescent with Sickle Cell Disease. ( 28758317 )
2017
13
Speckle tracking evaluation of right ventricular functions in children with sickle cell disease. ( 28928607 )
2017
14
Red blood cell alloimmunization in patients with sickle cell disease: correlation with HLA and cytokine gene polymorphisms. ( 27873324 )
2017
15
Prevalence and Clinical Characteristics of Rheumatoid Arthritis in an Inner City Population with Sickle Cell Disease. ( 28944097 )
2017
16
Perceived Racial Bias and Health-Related Stigma Among Youth with Sickle Cell Disease. ( 28059954 )
2017
17
GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia. ( 27885941 )
2017
18
Manifestations of sickle cell disease on thoracic imaging. ( 28946013 )
2017
19
Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help? ( 28054978 )
2017
20
A clinical risk score for pulmonary artery thrombosis during acute chest syndrome in adult patients with sickle cell disease. ( 28905364 )
2017
21
Acute vaso-occlusive crisis in patients with sickle cell disease. ( 28027139 )
2017
22
A Fatal Case of Immune Hyperhemolysis with Bone Marrow Necrosis in a Patient with Sickle Cell Disease. ( 28286630 )
2017
23
Laparoscopic cholecystectomy for cholelithiasis in children with sickle cell disease. ( 28555355 )
2017
24
Assessing responsiveness over time of the PROMIS(Ar) pediatric symptom and function measures in cancer, nephrotic syndrome, and sickle cell disease. ( 28884421 )
2017
25
Current Results and Future Research Priorities in Late Effects after Hematopoietic Stem Cell Transplantation (HCT) for Children with Sickle Cell Disease and Thalassemia: a Consensus Statement From the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT. ( 28065838 )
2017
26
Haploidentical hematopoietic bone marrow transplantation followed by living kidney transplantation from the same donor in a sickle cell disease patient with end-stage renal failure. ( 28160086 )
2017
27
Increased prevalence of renal cysts in patients with sickle cell disease. ( 28934953 )
2017
28
A Teenager With Sickle Cell Disease and Scalp Swelling. ( 28953104 )
2017
29
AAPT Diagnostic Criteria for Chronic Sickle Cell Disease Pain. ( 28065813 )
2017
30
Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. ( 28356267 )
2017
31
HLA-Haploidentical Stem Cell Transplant with Pre-Transplant Immunosuppression for Patients with Sickle Cell Disease. ( 28939451 )
2017
32
Treatments for priapism in boys and men with sickle cell disease. ( 28926088 )
2017
33
A Comment on Pattern of Opioid Use in Sickle Cell Disease. ( 28052380 )
2017
34
Degree of Anemia, Indirect Markers of Hemolysis, and Vascular Complications of Sickle Cell Disease in Africa. ( 28931524 )
2017
35
Interventions for treating intrahepatic cholestasis in people with sickle cell disease. ( 28759700 )
2017
36
The role of rs1984112_G at CD36 gene in increasing reticulocyte level among sickle cell disease patients. ( 27869039 )
2017
37
Acute Pain in Adolescents and Young Adults with Sickle Cell Disease: Delayed and Increased Opioid Dosing Following Transition to Adult Care. ( 28066934 )
2017
38
Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease. ( 28925802 )
2017
39
Risk Factors for 30-day Readmission in Adults with Sickle-Cell Disease. ( 28065771 )
2017
40
Preoperative screening for sickle cell disease and guidance from the National Institute for Health and Care Excellence (NICE). ( 28919074 )
2017
41
Enhanced Long-Term Brain MRI Evaluation of Children with Sickle Cell Disease Following Hematopoietic Cell Transplantation. ( 28089760 )
2017
42
Inflammatory and endothelial markers during vaso-occlusive crisis and acute chest syndrome in sickle cell disease. ( 28741692 )
2017
43
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea. ( 28078488 )
2017
44
Guidelines on red cell transfusion in sickle cell disease. Part I: principles and laboratory aspects. ( 28092109 )
2017
45
Extracorporeal Lung Support in Acute Chest Syndrome Associated With Sickle Cell Disease: A Rare Report of a Common Case. ( 28703372 )
2017
46
Incidence and predictive score for delayed hemolytic transfusion reaction in adult patients with sickle cell disease. ( 28924974 )
2017
47
RHD and RHCE genotyping by next-generation sequencing is an effective strategy to identify molecular variants within sickle cell disease patients. ( 28388467 )
2017
48
Turf wars: exploring splenomegaly in sickle cell disease in malaria-endemic regions. ( 28493472 )
2017
49
Expression pattern of CD55 and CD59 on red blood cells in sickle cell disease. ( 27667587 )
2017
50
The Sixth Vital Sign: Body Mass Index in Patients With Sickle Cell Disease. ( 28912927 )
2017

Variations for Sickle Cell Disease

ClinVar genetic disease variations for Sickle Cell Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HBB NM_000518.4(HBB): c.20A> T (p.Glu7Val) single nucleotide variant Pathogenic,protective rs334 GRCh37 Chromosome 11, 5248232: 5248232

Expression for Sickle Cell Disease

Search GEO for disease gene expression data for Sickle Cell Disease.

Pathways for Sickle Cell Disease

Pathways related to Sickle Cell Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.02 G6PD HBB HBG1 UGT1A1
2 11.65 HBB HBD HBG1 HBG2
3 10.68 HBA2 HBB VCAM1
4 10.61 HBA2 HBB SELP VCAM1

GO Terms for Sickle Cell Disease

Cellular components related to Sickle Cell Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.46 HBA2 HBB HBD HBG2
2 endocytic vesicle lumen GO:0071682 9.26 HBA2 HBB
3 hemoglobin complex GO:0005833 9.02 HBA2 HBB HBD HBG1 HBG2
4 haptoglobin-hemoglobin complex GO:0031838 8.96 HBA2 HBB

Biological processes related to Sickle Cell Disease according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.7 EPO PGF VCAM1
2 response to ethanol GO:0045471 9.61 G6PD UGT1A1 VCAM1
3 leukocyte cell-cell adhesion GO:0007159 9.51 SELP VCAM1
4 calcium-mediated signaling using intracellular calcium source GO:0035584 9.48 SELP VCAM1
5 hydrogen peroxide catabolic process GO:0042744 9.46 HBA2 HBB
6 blood coagulation GO:0007596 9.46 HBB HBD HBG1 HBG2
7 response to nutrient GO:0007584 9.43 EPO UGT1A1 VCAM1
8 leukocyte tethering or rolling GO:0050901 9.4 SELP VCAM1
9 cell volume homeostasis GO:0006884 9.37 KCNN4 SLC12A4
10 erythrocyte maturation GO:0043249 9.32 EPO G6PD
11 response to lipopolysaccharide GO:0032496 9.26 EPO SELP UGT1A1 VCAM1
12 oxygen transport GO:0015671 9.02 HBA2 HBB HBD HBG1 HBG2
13 transport GO:0006810 10.04 HBA2 HBB HBD HBG1 HBG2 KCNN4

Molecular functions related to Sickle Cell Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.65 HBA2 HBB HBD HBG1 HBG2
2 heme binding GO:0020037 9.55 HBA2 HBB HBD HBG1 HBG2
3 peroxidase activity GO:0004601 9.37 HBA2 HBB
4 oxygen binding GO:0019825 9.35 HBA2 HBB HBD HBG1 HBG2
5 haptoglobin binding GO:0031720 9.32 HBA2 HBB
6 oxygen transporter activity GO:0005344 9.02 HBA2 HBB HBD HBG1 HBG2

Sources for Sickle Cell Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....