Sickle Cell Disease malady

Genetics Home Reference: Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.¹⁷

MalaCards: Sickle Cell Disease, also known as sickling disorder due to hemoglobin s, is related to pulmonary hypertension and beta thalassemia. An important gene associated with Sickle Cell Disease is BCAM (basal cell adhesion molecule (Lutheran blood group)), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Glioma Invasiveness. The drug phenylbutyrate sodium and the compounds sodium nitroprusside and nicotine have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Sickle-cell disease (SCD), or sickle-cell anaemia (or anemia) (SCA) or drepanocytosis, is an autosomal...⁴⁴ more...

GeneReviews summary for sickle

sickle cell disease 15 16 17 32 sickling disorder due to hemoglobin s 17 hemoglobin s disease 17 anemia, sickle cell 43

sickle cell anemia 17 hbs disease 17 scd 17

Diseases related to sickle cell disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 984)

id	Related Disease	Score	Top Affiliating Genes
1	pulmonary hypertension	34.2	BMP4, BMPR2, FLT1, FGA, ANGPT1, NOS2
2	beta thalassemia	33.6	HBA2, HBB, HFE, TF, TFRC
3	acute chest syndrome	33.5	VCAM1, IL8, GP1BA, HLA-DQB1, HLA-DRB1, PLA2G10
4	hemoglobinopathy	33.4	KLF1, BTD, HP, G6PD, HBA2, HBB
5	alpha thalassemia	32.4	UGT1A1, G6PD, HBA1, HBA2, HBB, HBG1
6	priapism	32.0	KL, ITGAV, AQP1, F5, F13A1, GLA
7	hepatitis	31.3	RBP4, SELP, XDH, GUSB, ARG1, GPT
8	pyruvate kinase deficiency	30.9	MTHFR, ANXA5, PKLR, G6PD, HBA2, HFE
9	thrombosis	30.9	MTHFR, FGB, F8, F5, F2
10	hemochromatosis	30.7	B2M, IREB2, HP, ACO1, HFE, TF
11	siderosis	30.1	GPT, IGFBP3, IGF1, HMOX1, HBB, HFE
12	thromboembolism	30.1	VWF, SELP, SERPINE1, MTHFR, ITGA2, FGA
13	malaria	29.9	CD36, GYPE, IFNG, TNF, NOS2, G6PD
14	chronic myeloid leukemia	29.6	SELP, MYB, ITGB1, ITGB3, FN1, FCGR3B
15	gallbladder disease	29.5	UGT1A1, INS, APOA1, APOB, APOE, ALB
16	cholelithiasis	29.4	UGT1A1, GUSB, INS, APOA1, APOE, GPT
17	iron overload	29.0	RBP4, SELP, BMP6, UGT1A1, XDH, B2M
18	thalassemia	28.8	KLF1, VWF, SELE, VCAM1, MYB, BGLAP
19	immunodeficiency	28.6	SELL, BMP6, CD1A, CD1C, ITGA4, INS
20	sickle cell anemia	28.5	VWF, SELE, SELL, SELP, VCAM1, MYB
21	short stature	28.4	BGLAP, CFI, CD36, INS, IGFBP3, IGF1
22	intrahepatic cholangiocarcinoma	28.3	SELL, SAA4, FGA, IL6, AQP1, GPT
23	gaucher's disease	28.2	BGLAP, GUSB, F9, GLA, PKLR, HBB
24	asthma	27.9	SERPINE1, IL1B, CCR5, CCL5, IFNG, ALOX5
25	familial combined hyperlipidemia	27.5	VWF, SERPINE1, CD36, FN1, INS, APOA1
26	hepatitis b	27.4	MBL2, CCR5, GPT, IFNG, F2, ALB
27	chronic lymphocytic leukemia	27.2	SELL, MYB, B2M, ITGA4, ANXA5, CCR5
28	skin disease	26.9	SELE, SELL, CD1C, ITGB1, IL8, IFNG
29	osteomyelitis	26.8	CD36, ITGA2, IL1B, IL6, IL8, CCL5
30	non-hodgkin lymphoma	26.7	SELL, MYB, B2M, ITGA4, ITGB1, FGA
31	primary hyperparathyroidism	26.4	KL, VWF, SELE, SERPINE1, BGLAP, B2M
32	atopic dermatitis	26.1	SELE, SELL, SELP, VCAM1, FCGR3A, IL8
33	pulmonary function	26.0	CD36, INS, IL6, IL8, GPT, IFNG
34	hypertriglyceridemia	25.9	RBP4, SELE, SELP, SERPINE1, VCAM1, INS
35	periodontitis	25.9	CD36, FCGR3A, IL1B, IL6, IL8, CCR5
36	proteinuria	25.8	VWF, RBP4, SELL, SELP, SERPINE1, VEGFA
37	cutaneous leishmaniasis	25.6	BMP6, IL6, IL8, CCR5, GPI, GPT
38	fatty liver disease	25.3	RBP4, SERPINE1, CD36, INS, IL6, APOA1
39	cholangiocarcinoma	25.3	SELE, SELL, VEGFA, BMP6, MTHFR, SAA4
40	leukemia/lymphoma	25.1	VEGFA, VCAM1, BGLAP, MTHFR, B2M, ITGA4
41	amyloidosis	24.7	VWF, RBP4, BGLAP, SAA4, B2M, INS
42	hyperparathyroidism	24.6	KL, VWF, SELE, SERPINE1, VEGFA, BGLAP
43	human immunodeficiency virus infectious disease	24.5	SELL, B2M, INS, IL1B, IL6, CCR2
44	glaucoma	24.1	VWF, SELE, SERPINE1, VEGFA, BMP4, BMP6
45	kaposi's sarcoma	23.9	VWF, SELE, SELP, VEGFA, VCAM1, UGT1A1
46	cerebrovascular disease	23.9	VWF, SELE, SELL, SELP, SERPINE1, VEGFA
47	arthropathy	23.5	BMP6, BGLAP, B2M, IL1B, IL6, IL8
48	systemic lupus erythematosus	23.5	VWF, RBP4, SELE, VCAM1, CFI, ITGA4
49	hyperlipidemia	23.5	VWF, RBP4, SELP, SERPINE1, VCAM1, MTHFR
50	type 2 diabetes mellitus	23.2	VWF, RBP4, SELE, SELL, SELP, SERPINE1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 phenylbutyrate sodium

Cell-based therapeutics:

Genetic tests related to sickle cell disease:

id	Genetic test	Affiliating Genes
1	Sickle Cell Disease clinical/research	HBB, HBD

MalaCards organs/tissues related to sickle cell disease:

²²

MGI Mouse Phenotypes related to sickle cell disease:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	PGF, ACVRL1, NOS1, CALCA, F13A1, CCR2
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	GUSB, KCNN4, KL, SELL, SERPINA5, IFNG
3	embryogenesis phenotype	MP:0005380	10.1	GPI, COMT, EPOR, CSF2, DNMT1, ACVRL1
4	renal/urinary system phenotype	MP:0005367	10.1	EPB41, SLC4A1, OCA2, CFI, BCAM, BMP4
5	hematopoietic system phenotype	MP:0005397	9.9	KLF1, EPOR, EPO, EPB41, HAMP, ADAMTS13
6	other phenotype	MP:0005395	9.7	CSF1, HBB, NOS3, NOS2, NOS1, CCR2
7	integument phenotype	MP:0010771	9.4	F5, BTD, KLF1, KL, SELP, BRCA1
8	nervous system phenotype	MP:0003631	8.5	ITGB1, KL, ITGAV, CD36, MTHFR, BCL11A
9	liver/biliary system phenotype	MP:0005370	8.1	EPO, CCR5, CCR2, ANK1, APOB, APOA1
10	digestive/alimentary phenotype	MP:0005381	8.1	KL, VWF, BRCA1, VEGFA, BMP4, BCAM
11	skeleton phenotype	MP:0005390	7.8	THBS1, HIF1A, HBB, NOS1, PLAT, DARC
12	normal phenotype	MP:0002873	7.8	HIF1A, HBG1, HBB, ACVRL1, ACO1, EPOR
13	growth/size phenotype	MP:0005378	7.6	HIF1A, HBB, HBA2, ACVRL1, ACE, NOS3
14	immune system phenotype	MP:0005387	7.4	LTF, F8, F9, IFNG, ANK1, MBL2
15	reproductive system phenotype	MP:0005389	6.9	CSF1, OCA2, TGFBR3, THBS1, AGT, HBB
16	adipose tissue phenotype	MP:0005375	6.8	NOS1, NOS2, ACE, AGT, CSF2, OCA2
17	behavior/neurological phenotype	MP:0005386	6.6	CSF2, SLC17A5, SIL1, ANK1, CCR5, GDF15
18	tumorigenesis	MP:0002006	6.4	TNF, B2M, SERPINE1, IFNG, ICAM1, F3
19	mortality/aging	MP:0010768	6.1	HP, CCR2, MAPK8, ANGPT1, ANK1, ANGPT2
20	muscle phenotype	MP:0005369	5.9	IGF1, CD36, XDH, KCNN4, BMPR2, BMP4
21	vision/eye phenotype	MP:0005391	5.9	TNF, PLAT, NOS1, F3, ICAM1, IFNG
22	homeostasis/metabolism phenotype	MP:0005376	5.5	SOD1, EPOR, EPO, CSF1, CSF2, CST3
23	cellular phenotype	MP:0005384	4.6	IFNG, GUSB, FLT1, FN1, ITGB3, ITGB1
24	cardiovascular system phenotype	MP:0005385	3.6	G6PD, F5, ENG, APOE, APOB, APOA1

Articles related to sickle cell disease:

(show top 50)    (show all 224)

id	Title	Authors	Year	Affiliating Genes
1	Association of the +874 T/A interferon gamma polymorp hism with infections in sickle cell disease. (20477883)	Joannes M.O.... Marianne-Pepin T.	2010	IFNG
2	Mutation -538 T/C in bone morphogenetic protein 4 do not increase the risk in sickle-cell disease with orthopedic complications but strongly associated with increased LDH and uric acid level in Indian patients f rom Chhattisgarh and Jharkhand states. (20144598)	Abhishek K.... Choudhary S.B.	2010	BMP4
3	P-selectin-mediated platelet-neutrophil aggregate for mation activates neutrophils in mouse and human sickle cell disease. (21071696)	Polanowska-Grabowska R.... Linden J.	2010	SELP
4	Frequency of the MTHFR C677T polymorphism in Yemeni c hildren with sickle cell disease. (20113291)	Al-Saqladi A.W.... Brabin B.J.	2010	MTHFR
5	Osteopenia and vitamin D deficiency in children with sickle cell disease. (19682065)	Chapelon E.... de Montalembert M.	2009	BGLAP
6	Differences in response to fetal hemoglobin induction therapy in beta-thalassemia and sickle cell disease. (19346141)	Fathallah H.... Atweh G.F.	2009	HBA2, HBG1
7	Molecular biology of the Rh system: clinical consider ations for transfusion in sickle cell disease. (20008197)	Chou S.T.... Westhoff C.M.	2009	RHD
8	Plasma annexin A5 and microparticle phosphatidylserin e levels are elevated in sickle cell disease and increase further during painfu l crisis. (19799864)	van Tits L.J.... Schnog J.B.	2009	ANXA5
9	Pathophysiology of transfusional iron overload: contr asting patterns in thalassemia major and sickle cell disease. (20001631)	Porter J.B.	2009	HMOX1, GDF15
10	Elevated circulating stromal-derived factor-1 levels in sickle cell disease. (19816012)	Landburg P.P.... Duits A.J.	2009	CXCL12
11	Proteomic identification of altered apolipoprotein pa tterns in pulmonary hypertension and vasculopathy of sickle cell disease. (19023114)	Yuditskaya S.... Kato G.J.	2009	APOA1
12	HLA-G polymorphism influences the susceptibility to H CV infection in sickle cell disease patients. (19775370)	Cordero E.A.... Chies J.A.	2009	HLA-G
13	The pharmacokinetics of codeine and its metabolites in Blacks with sickle cell disease. (19357842)	Shord S.S.... Molokie R.E.	2009	CYP2D6
14	rs660 polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. (19201475)	Tatari-Calderone Z.... Vukmanovic S.	2009	TRIM21
15	Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions. (18513257)	Fung E.B.... Vichinsky E.P.	2008	GPT
16	Histopathology of experimentally induced asthma in a murine model of sickle cell disease. (18579795)	Nandedkar S.D.... Pritchard K.A.	2008	EPX
17	UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. (17724700)	Darbari D.S.... van den Anker J.	2008	UGT2B7
18	Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease. (18248572)	Afenyi-Annan A.... Telen M.J.	2008	DARC
19	Soluble P-selectin and vascular endothelial growth factor in steady state sickle cell disease: relationship to genotype. (18080800)	Blann A.D.... Lip G.Y.	2008	SELP, VEGFA, HBB
20	Neonatal screening for sickle cell disease in Central Africa: a study of 1825 newborns with a new enzyme-linked immunosorbent assay test. (17925082)	Mutesa L.... Schoos R.	2007	HBB
21	Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. (17353439)	Raghavachari N.... Gladwin M.T.	2007	ARG2
22	Genetic polymorphisms associated with priapism in sickle cell disease. (17408468)	Elliott L.... Telen M.J.	2007	NOS3, SLC4A1, ITGAV
23	High levels of neopterin and interleukin-3 in sickle cell disease patients. (16721831)	Rodrigues L.... Grotto H.Z.	2006	IL3
24	Platelet P-selectin and platelet mass, volume and component in sickle cell disease: relationship to genotype. (16051315)	Mohan J.S.... Blann A.D.	2006	SELP, PPBP
25	Acute abdominal pain due to splenic infarction in a patient with heterozygous sickle cell disease exposed to high altitude (17211489)	Ruiz Semba E.... ChA!vez Gil V.	2006	HBB
26	Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. (16885048)	Little J.A.... Gladwin M.T.	2006	EPO
27	Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease. (15537646)	Graslund T.... Barbas C.F.	2005	HBG1
28	Polymorphisms of chemokine receptors and eNOS in Brazilian patients with sickle cell disease. (16305685)	Vargas A.E.... Chies J.A.	2005	NOS3, CCR5, CCR2
29	Increased adhesive properties of eosinophils in sickle cell disease. (15308324)	Canalli A.A.... Costa F.F.	2004	FN1
30	Steady-state plasma lactoferrin levels in relation to infections and complications of sickle cell disease. (15297857)	Okpala I.... Greaves R.	2004	LTF
31	B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. (14755370)	Zen Q.... Telen M.J.	2004	BCAM
32	Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia. (15224376)	Fawaz N.A.... Almawi W.Y.	2004	F2, F5, MTHFR
33	Beta-globin gene cluster haplotypes and HbF levels are not the only modulators of sickle cell disease in Lebanon. (12581188)	Inati A.... Zalloua P.A.	2003	HBB
34	Red blood cells from patients with homozygous sickle cell disease provide a catalytic surface for factor Va inactivation by activate d protein C. (11972526)	Bezeaud A.... Guillin M.C.	2002	F10
35	Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. (11238038)	Nath K.A.... Hebbel R.P.	2001	HMOX1
36	Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: a case-control study. (11754397)	Tang D.C.... Rodgers G.P.	2001	AGT
37	Modulation of endothelial cell activation in sickle cell disease: a pilot study. (11264155)	Solovey A.A.... Hebbel R.P.	2001	SELE
38	Sickle-cell disease not identified by newborn screening because of prior transfusion. (10657834)	Reed W.... Vichinsky E.P.	2000	BTD
39	Elevated serum and bronchoalveolar lavage fluid levels of interleukin 8 and granulocyte colony-stimulating factor associated with the acute chest syndrome in patients with sickle cell disease. (11122088)	Abboud M.R.... Ballas S.K.	2000	IL8
40	Soluble transferrin receptor in sickle cell diseases: correlation with spleen function. (10559849)	Grotto H.Z.... Carneiro M.V.	1999	TFRC
41	Sickle cell disease in Bahrain: coexistence and interaction with glucose-6-phosphate dehydrogenase (G6PD) deficiency. (9604591)	Mohammad A.M.... Bajakian K.M.	1998	G6PD
42	Butyrate in the treatment of sickle cell disease and beta-thalassemia. (9371980)	Faller D.V.... Perrine S.P.	1995	HBG1
43	Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease. (7708766)	Takekoshi K.J.... Leboulch P.	1995	HBB, HBD
44	Enhanced thrombin generation in children with sickle cell disease. (8191393)	Peters M.... Brandjes D.P.	1994	SERPINA5
45	Monitoring the acute phase response to vaso-occlusive crisis in sickle cell disease. (7510726)	Stuart J.... Pepys M.B.	1994	SAA4
46	Clinical value of C-reactive protein, alpha 1-glycoprotein acid and transferrin assay in homozygous sickle cell disease (8292921)	Monnet D.... Yapo A.E.	1993	TF
47	Platelet regulatory prostanoids and platelet release products in sickle cell disease. (1533087)	Longenecker G.L.... Mankad V.N.	1992	PPBP
48	Effect of G-6 PD deficiency on sickle cell disease in Saudi Arabia. (1398867)	Awamy B.H.	1992	G6PD
49	Erythropoietin in anemia of renal failure in sickle cell disease. (1891029)	Roger S.D.... Raine A.E.	1991	EPO
50	Impaired erythrocyte methemoglobin reduction in sickle cell disease: dependence of methemoglobin reduction on reduced nicotinamide adenine dinucleotide content. (2393709)	Zerez C.R.... Tanaka K.R.	1990	HBG2

Genes related to sickle cell disease according to GeneCards:

(show top 50)    (show all 170)

id	Symbol	Description	Score	GeneCards Section Context
1	BCAM	basal cell adhesion molecule (Lutheran blood group)	11.1	Publications, Summaries
2	HBS1L	HBS1-like (S. cerevisiae)	11.1	Publications, Summaries
3	HBB	hemoglobin, beta	11.0	Publications
4	SLC12A4	solute carrier family 12 (potassium/chloride transporters), member 4	11.0	Expressions
5	HBG1	hemoglobin, gamma A	11.0	Publications
6	HBD	hemoglobin, delta	11.0	Publications
7	HBA2	hemoglobin, alpha 2	11.0	Publications
8	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
9	PLA2G10	phospholipase A2, group X	11.0	Publications
10	PGF	placental growth factor	11.0	Publications
11	DLX4	distal-less homeobox 4	11.0
12	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
13	KCNN4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	11.0	Publications
14	ALAS2	aminolevulinate, delta-, synthase 2	11.0	Publications
15	GYPE	glycophorin E (MNS blood group)	11.0
16	RHD	Rh blood group, D antigen	11.0	Publications
17	CFI	complement factor I	11.0	Publications
18	SELL	selectin L	11.0	Publications
19	EPOR	erythropoietin receptor	11.0	Publications
20	BTD	biotinidase	11.0	Publications
21	EPO	erythropoietin	11.0	Publications
22	PF4	platelet factor 4	11.0	Publications
23	HP	haptoglobin	11.0	Publications
24	HBG2	hemoglobin, gamma G	11.0	Publications
25	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	11.0	Publications
26	ANGPT2	angiopoietin 2	11.0
27	FGA	fibrinogen alpha chain	11.0	Publications
28	GLA	galactosidase, alpha	11.0
29	SELE	selectin E	11.0	Publications
30	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
31	EDN1	endothelin 1	11.0	Publications
32	F9	coagulation factor IX	11.0
33	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
34	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
35	THBS1	thrombospondin 1	11.0	Publications
36	GUSB	glucuronidase, beta	11.0
37	TFRC	transferrin receptor (p90, CD71)	11.0	Publications
38	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
39	TF	transferrin	11.0	Publications
40	ANXA5	annexin A5	11.0	Publications
41	ANGPT1	angiopoietin 1	11.0
42	DNMT1	DNA (cytosine-5-)-methyltransferase 1	11.0	Publications
43	VWF	von Willebrand factor	11.0	Publications
44	ADAMTSL1	ADAMTS-like 1	11.0
45	BRCA1	breast cancer 1, early onset	11.0
46	FCP1	F-cell production 1	11.0	Publications
47	HPFH	hereditary persistence of fetal hemoglobin, heterocellular	11.0	Publications
48	MIR144	microRNA 144	11.0	Publications
49	ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	11.0	Publications
50	CD1C	CD1c molecule	11.0	Publications

Pathways related to sickle cell disease according to GeneDecks:

(show top 50)    (show all 106)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.7	ITGA4, ITGAV, IGF1, PPBP, PGF, BMP4
2	Glioma Invasiveness36	10.5	ITGB1, ITGAV, IL3, PGF, PPBP, ITGA4
3	Extrinsic Prothrombin Activation Pathway36	10.5	FGB, F7, F5, F3, F2, F10
4	Cell adhesion_Integrin inside-out signaling41	10.4	FGA, ITGA2, ITGAV, ITGB1, ITGB3, FN1
5	PTEN Pathway36	10.4	ITGA2B, ITGA2, BMP4, PGF, TGFBR3, PPBP
6	ECM-receptor interaction20	10.3	GP1BA, VWF, CD36, ITGA2, ITGA2B, ITGB1
7	Staphylococcus aureus infection20	10.3	HLA-DRB1, HLA-DQB1, FCGR3B, FCGR3A, FCGR2A, CFI
8	Angiogenesis3	10.3	HIF1A, TGFBR3, NOS3, HMOX1, ENG, ITGB3
9	Blood Coagulation Cascade36	10.2	F7, F2, F10, FGA, FGB, F3
10	Ras Pathway36	10.2	PPBP, EPOR, FLT1, CXCL12, PGF, ITGAV
11	Complement and coagulation cascades20	10.1	F3, F2, F10, F13A1, PLAT, THBD
12	Blood Coagulation Signaling Pathways37	10.1	F7, F5, F3, F2, F10, F13A1
13	Phagosome20	10.0	THBS1, CD36, ITGA2, ITGAV, ITGB1, ITGB3
14	Focal adhesion20	9.9	ITGA4, VWF, FN1, THBS1, MAPK8, FLT1
15	Cell adhesion Integrin inside-out signaling10	9.9	CXCL12, F2, FGB, FGA, ITGB3, ITGAV
16	RAR-Gamma-RXR-Alpha Degradation36	9.9	CXCL2, CSF3, BMP4, IL3, ANGPT1, CCL5
17	Paxillin Interactions36	9.8	PGF, MAPK8, IL3, FLT1, ITGB3, BMP4
18	Regulation of eIF4 and p70S6K36	9.5	ITGA2, ITGA2B, ITGA4, ITGB1, ITGB3, IL3
19	Molecular Mechanisms of Cancer36	9.0	BRCA1, MAPK8, CCL5, PPBP, PF4, ACVRL1
20	Phospholipase-C Pathway36	9.0	FLT1, IGF1, PPBP, ITGA2B, PLA2G10, TGFBR3
21	Rap1 Pathway36	9.0	IL3, IL6, IGF1, PPBP, CXCL12, ITGB1
22	Rac1 Pathway36	8.9	ITGB3, ITGB1, BMP4, ITGAV, ITGA4, ITGA2B
23	ERK Signaling36	8.8	ITGA2B, BMP6, ANGPT1, BMP4, FLT1, CSF3
24	Endothelin-1 Signaling Pathway36	8.7	EPOR, CSF3, CSF1, CXCL2, BMP6, NOS1
25	p70S6K Signaling36	8.7	MAPK8, F2, PPBP, HBG1, IL3, IGF1
26	PPAR Pathway36	8.6	PPBP, ITGA2, ITGA2B, ITGA4, ITGAV, ITGB1
27	Leishmaniasis20	8.6	NOS2, IL1B, IFNG, HLA-DQB1, HLA-DRB1, TNF
28	African trypanosomiasis20	8.5	SELE, VCAM1, IL1B, IL6, APOA1, IFNG
29	Akt Signaling36	8.4	CCR5, ITGA2, ANGPT1, IL6, ITGA2B, BMPR2
30	Rho Family GTPases36	8.1	EPOR, BMP4, BMP6, ITGA2, MAPK8, CCL5
31	JAK-STAT Pathway36	8.1	IL1B, PPBP, IGF1, EPO, BMP6, CCL5
32	Hematopoietic cell lineage20	7.9	CD36, CD1B, CD1A, CD1C, ITGA2, ITGA2B
33	Immune response IL-1 signaling pathway10	7.9	EDN1, NOS2, TNF, HMOX1, F3, MAPK8
34	Immune response_IL-1 signaling pathway41	7.9	EDN1, NOS2, TNF, HMOX1, IL1B, SERPINE1
35	Malaria20	7.9	SELE, SELP, HBD, THBS1, CSF3, HBB
36	TGF-Beta Pathway36	7.6	IL3, IL1B, FLT1, BMP6, BMP4, IL6
37	MAPK Signaling36	7.5	FLT1, PPBP, TNF, BMP4, BMP6, ITGA2
38	MIF Mediated Glucocorticoid Regulation36	7.3	ANGPT2, CCL5, TNF, PF4, BMP4, ANGPT1
39	PEDF Induced Signaling36	7.3	CSF3, CSF2, CSF1, CXCL2, CXCL12, PF4
40	IL-6 Pathway36	7.3	ANGPT1, IL6, IL3, IL1B, BMP6, BMP4
41	all-trans-Retinoic Acid Signaling in Brain36	7.3	IL6, IL3, IL1B, BMP6, ALOX5, CSF2
42	Tec Kinases Signaling36	7.2	BMP4, BMP6, BMPR2, MAPK8, CCR2, CCR5
43	p38 Signaling36	7.1	CXCL12, BMP6, CXCL2, CSF1, CSF2, CSF3
44	MIF Regulation of Innate Immune Cells36	7.0	IL3, CSF1, CSF2, CSF3, BMP4, MAPK8
45	MAPK Family Pathway36	7.0	CXCL12, PGF, TGFBR3, PPBP, TNF, BMP4
46	STAT3 Pathway36	6.9	CCL5, TNF, PF4, ACVRL1, CXCL12, CXCL2
47	PAK Pathway36	6.9	CXCL12, CXCL2, CSF1, CSF2, CSF3, PGF
48	Antioxidant Action of Vitamin-C36	6.8	BMP6, FLT1, IL1B, IL3, IL6, IL8
49	Rheumatoid arthritis20	6.6	IL8, ANGPT1, CCL5, IFNG, ICAM1, HLA-DQB1
50	Cytokine-cytokine receptor interaction20	6.6	CCR2, TNF, CSF2, CSF1, CXCL2, PF4

Compounds related to sickle cell disease according to GeneDecks:

(show top 50)    (show all 537)

id	Compound	Score	Top Affiliating Genes
1	sodium nitroprusside32	10.5	VWF, MYB, BMP6, IREB2, HMOX1, COX5A
2	nicotine32 34 9 9	13.5	SELL, UGT1A1, UGT2B7, GPT, CYP2C19, CYP2D6
3	methionine32	10.3	VWF, MYB, CFI, ITGA2, FN1, GYPE
4	ptca32	10.3	SELP, SAA4, FGA, CCL5, F3, PPBP
5	isoproterenol32 9 9	12.3	PDE3A, SELL, IL3, NOS2, COMT, LTF
6	budesonide32 42 9 9	13.2	BGLAP, CD36, LTF, CSF2, EPX
7	polyethylene glycol32	10.1	SELE, FN1, APOA1, APOE, F8, ALPP
8	aprotinin32 9 9	12.0	VWF, SELP, FN1, FGA, GP1BA, IGF1
9	sele32	10.0	SELE, SELL, SELP, VCAM1, MTHFR, ITGB3
10	latex32	9.9	VWF, RBP4, SAA4, ITGA2, FN1, FGA
11	pge232	9.9	SELE, VCAM1, BMP4, FN1, ARG1, APOA1
12	azathioprine32 34 9 9	12.7	BMP4, BGLAP, MTHFR, XDH, CCL5, GPT
13	phosphatidylcholine32	9.5	SELE, VCAM1, CD1B, ITGA2, ITGB1, FN1
14	polysulfone32	9.5	VWF, SELL, SELP, VCAM1, B2M, FGA
15	ascorbic acid32 18	10.4	RBP4, BMP4, BGLAP, CD36, IL3, ENG
16	captopril32 42 9 9	12.4	B2M, APOA1, APOB, F3, ALB, CALCA
17	adenylate32	9.3	PDE3A, VWF, RBP4, SELE, SELP, SERPINE1
18	pioglitazone32 9 9	11.2	RBP4, VEGFA, VCAM1, FN1, INS, APOA1
19	phosphatidylinositol32	9.2	VCAM1, BMP4, BMP6, ITGA2, ITGA4, ITGB1
20	mycophenolate mofetil32 9 9	11.2	SELE, SELP, SERPINE1, UGT1A1, UGT2B7, CD36
21	testosterone32 9 18 9	12.1	SELE, BRCA1, VCAM1, BGLAP, UGT1A1, UGT2B7
22	valine32	9.0	RBP4, MTHFR, B2M, ARG1, FCGR2A, FCGR3A
23	polysaccharide32	9.0	SELE, SELL, SELP, VCAM1, BMP6, B2M
24	alpha tocopherol32	9.0	RBP4, VCAM1, BGLAP, MTHFR, SAA4, XDH
25	rapamycin32 42	9.9	SELL, VEGFA, MYB, BMP4, FN1, FLT1
26	h2o232	8.9	VWF, SELL, BRCA1, MYB, BGLAP, XDH
27	uric acid32 18	9.9	RBP4, SERPINE1, MTHFR, SAA4, XDH, B2M
28	zidovudine32 9 9	10.8	UGT2B7, B2M, GUSB, IL3, CCR5, GPT
29	epinephrine32 9 18 9	11.8	SELE, SELL, SELP, BMP6, UGT2B7, ITGA2
30	dextran sulfate32	8.7	SELE, SELL, SELP, CD36, FN1, GYPE
31	losartan32 34 9 9	11.6	VWF, SELE, SELP, SERPINE1, VCAM1, BMP6
32	glutamate32	8.4	BMP6, MTHFR, ITGA2, ARG1, INS, ANXA5
33	fenofibrate32 9 9	10.2	SELE, SELP, SERPINE1, VCAM1, INS, IL6
34	fibrinogen32	8.1	SELE, SELP, SERPINA5, SERPINE1, VCAM1, SAA4
35	norepinephrine32 9 18 9	11.1	VWF, SELE, SELL, SELP, VCAM1, BMP6
36	cysteine32	8.1	PDE3A, BTD, RBP4, SELP, BRCA1, MYB
37	atorvastatin32 34 9 18 9	11.8	VWF, SELE, SELL, SELP, VEGFA, VCAM1
38	rosiglitazone32 9 18 9	10.7	RBP4, SELE, SERPINE1, VCAM1, CD36, INS
39	pdtc32	7.5	SELE, VCAM1, XDH, IL6, IL8, ANXA5
40	superoxide32 18	8.4	SELL, VCAM1, XDH, FLT1, GUSB, FCGR3B
41	ly29400232	7.2	SELE, VEGFA, FN1, FCGR2A, IL1B, IL6
42	polymyxin b32	7.1	SELE, SERPINE1, VCAM1, IL1B, IL6, IL8
43	cholesterol32 9 18 9	10.0	VWF, RBP4, SELE, SELP, SERPINE1, VCAM1
44	15-deoxy-delta-12,14-prostaglandin j232	6.8	SERPINE1, VEGFA, VCAM1, BMP6, CD36, IL1B
45	pd 98,05932	6.7	SERPINE1, VCAM1, BMP4, BMP6, UGT1A1, ITGB1
46	alanine32	6.4	PDE3A, VWF, BTD, RBP4, SELE, SELL
47	sb 20358032 42	7.4	SELE, VEGFA, VCAM1, BMP4, BMP6, BGLAP
48	hydrocortisone32 9 9	8.3	BMP6, BGLAP, CD36, FLT1, INS, IL1B
49	lactate32	5.6	VWF, BTD, RBP4, SELE, SELL, SELP
50	actinomycin d32	5.2	SELE, SERPINE1, VEGFA, MYB, BMP4, FN1

Cellular components related to sickle cell disease according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	hemoglobin complex	GO:005833	10.8	HBD, HBB, HBA2, HBG1, HBG2
2	platelet alpha granule	GO:031091	10.7	THBS1, FGB, SERPINA5, VWF, FGA
3	cortical cytoskeleton	GO:030863	10.3	EPB41, SLC4A1, ANK1, SELE, NOS2
4	integrin complex	GO:008305	10.1	ITGB3, ITGA2, ITGA4, ITGAV, ITGB1, ITGA2B
5	platelet alpha granule membrane	GO:031092	10.0	ITGB3, ITGA2B, CD36, SELP
6	platelet alpha granule lumen	GO:031093	9.6	PF4, PPBP, F13A1, ALB, F5, F8
7	secretory granule	GO:030141	8.9	VEGFA, INS, IL1B, APOA1, THBS1, TF
8	cell surface	GO:009986	8.6	ALPP, ACVRL1, THBD, TGFBR3, ADAMTS13, TNF
9	integral to plasma membrane	GO:005887	8.6	EPOR, GP1BA, ITGA2B, TNF, HLA-DRB1, ICAM1
10	external side of plasma membrane	GO:009897	8.4	THBS1, ACE, TNF, HLA-DRB1, ICAM1, IFNG
11	plasma membrane	GO:005886	6.8	F10, ANGPT2, APOE, APOB, APOA1, AQP1
12	extracellular region	GO:005576	4.8	EPO, PLA2G10, CRP, PPBP, HP, GLA
13	extracellular space	GO:005615	3.1	GDF15, EPO, ADAMTS13, PGF, NPPB, CST3

Biological processes related to sickle cell disease according to GeneDecks:

(show all 50)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood vessel remodeling	GO:001974	10.7	ACVRL1, NOS3, IGF1, CCR2, AGT, ITGA4
2	cellular iron ion homeostasis	GO:006879	10.6	TFRC, ALAS2, HAMP, TF, SOD1, HFE
3	leukocyte cell-cell adhesion	GO:007159	10.6	ICAM1, VCAM1, CALCA, SELP, ITGA4, ITGB1
4	response to estrogen stimulus	GO:043627	10.6	HMOX1, EPO, CCL5, F7, BGLAP, SERPINE1
5	blood coagulation, intrinsic pathway	GO:007597	10.5	F10, F2, VWF, GP1BA, F8, F9
6	positive regulation of blood coagulation	GO:030194	10.5	THBS1, F2, SERPINE1, F7, CD36
7	response to organic cyclic compound	GO:014070	10.5	COMT, UGT1A1, BMP4, SELP, F7, ANGPT2
8	regulation of immune response	GO:050776	10.5	ITGB1, ITGA4, FCGR3A, ICAM4, VCAM1, SELL
9	leukocyte migration	GO:050900	10.5	ITGAV, SELL, SELP, ANGPT2, THBD, F2
10	positive regulation of endothelial cell migration	GO:010595	10.4	THBS1, VEGFA, BMP4, ITGB3, EDN1, AGT
11	blood coagulation, extrinsic pathway	GO:007598	10.4	F10, F3, F7, F9
12	regulation of blood pressure	GO:008217	10.4	SOD1, CALCA, HMOX1, NPPB, HBB, NOS3
13	cell-matrix adhesion	GO:007160	10.4	AGT, ADAMTS13, ITGB1, ITGAV, ITGA2B, ITGA2
14	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.3	PF4, PLA2G10, APOB, CD36, CSF2, AGT
15	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.2	IGF1, AGT, SELP, INS, ANGPT1, CCL5
16	response to lipopolysaccharide	GO:032496	10.1	SELE, SELP, EPO, THBD, EDN1, COMT
17	positive regulation of vasodilation	GO:045909	10.0	HMOX1, NOS1, NOS3, CALCA, INS
18	aging	GO:007568	9.9	F3, VCAM1, IL1B, CCL5, NOS3, AGT
19	cell adhesion	GO:007155	9.9	CD36, SELL, VCAM1, ITGAV, ITGA2B, BGLAP
20	negative regulation of smooth muscle cell proliferation	GO:048662	9.8	COMT, NPPB, NOS3, IFNG, IGFBP3, HMOX1
21	interferon-gamma-mediated signaling pathway	GO:060333	9.8	HLA-G, HLA-DRB1, VCAM1, PTAFR, B2M, IFNG
22	positive regulation of endothelial cell proliferation	GO:001938	9.8	ACVRL1, CXCL12, BMP4, BMP6, BMPR2, ITGB3
23	angiogenesis	GO:001525	9.7	HIF1A, SERPINE1, GPI, VEGFA, ITGAV, FN1
24	positive regulation of cell migration	GO:030335	9.7	CSF1, F7, F3, CCL5, FLT1, ITGAV
25	positive regulation of cell adhesion	GO:045785	9.6	IFNG, CCL5, ANGPT1, ITGAV, VEGFA, SELP
26	cellular response to lipopolysaccharide	GO:071222	9.6	SERPINE1, ARG2, CD36, ARG1, IL8, CCR5
27	positive regulation of angiogenesis	GO:045766	9.6	THBS1, SERPINE1, VEGFA, FLT1, HIF1A, NOS3
28	platelet degranulation	GO:002576	9.5	FGA, FGB, APOA1, IGF1, F8, F5
29	positive regulation of neuron differentiation	GO:045666	9.5	CXCL12, IFNG, EPO, BMP6, ITGB1, BMP4
30	response to heat	GO:009408	9.5	SOD1, PKLR, NOS3, NOS1, CALCA, IL1B
31	response to mechanical stimulus	GO:009612	9.4	CXCL12, NOS3, F3, BGLAP, BMP4, ANGPT2
32	small molecule metabolic process	GO:044281	9.4	APOE, GPT, EPT1, SLC4A1, APOB, APOA1
33	positive regulation of protein kinase B signaling cascade	GO:051897	9.4	IGF1, F10, F3, F7, THBS1, INS
34	acute-phase response	GO:006953	9.2	IL6, MBL2, SAA4, INS, FN1, F8
35	positive regulation of MAPK cascade	GO:043410	9.2	ITGB1, INS, CD36, IGFBP3, AGT, IGF1
36	anti-apoptosis	GO:006916	9.1	F3, HMOX1, TNF, NOS3, THBS1, SOD1
37	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	CD36, ANGPT1, VEGFA, IL6, IL3, INS
38	negative regulation of lipid storage	GO:010888	9.1	TNF, CRP, ITGAV, ITGB3, IL6
39	immune response	GO:006955	9.0	HLA-DRB1, HFE, PF4, HLA-DQB1, PTAFR, THBS1
40	positive regulation of smooth muscle cell proliferation	GO:048661	9.0	EDN1, IGF1, CCL5, BMP4, FLT1, IL6
41	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	9.0	VEGFA, IL1B, ITGB3, FLT1, HIF1A
42	response to drug	GO:042493	8.9	AQP1, ARG1, ARG2, CCL5, PDE3A, BGLAP
43	platelet activation	GO:030168	8.8	CD36, GP1BA, IGF1, F8, F5, F2
44	blood coagulation	GO:007596	8.6	THBS1, THBD, HBG2, HBG1, HBD, HBB
45	positive regulation of nitric oxide biosynthetic process	GO:045429	8.6	INS, TNF, IL1B, IFNG, ICAM1, EDN1
46	cytokine-mediated signaling pathway	GO:019221	8.5	B2M, HLA-DQB1, CSF3, VCAM1, IFNG, HLA-DRB1
47	positive regulation of cell proliferation	GO:008284	8.5	EPO, PGF, CSF3, CSF2, INS, FLT1
48	response to hypoxia	GO:001666	7.9	FLT1, THBS1, TGFBR3, CXCL12, PGF, NOS3
49	negative regulation of apoptotic process	GO:043066	7.6	ALB, SERPINE1, IL6, EPO, VEGFA, BMP4
50	inflammatory response	GO:006954	7.5	SELE, SELP, BMP6, IL1B, IL6, IL8

Molecular functions related to sickle cell disease according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic cell surface binding	GO:043499	10.8	FGA, SELP, FGB, MBL2, ANXA5, THBS1
2	oxygen transporter activity	GO:005344	10.7	HBA2, HBG2, HBB, HBG1, HBD
3	heme binding	GO:020037	10.6	CYP2C19, CYP2D6, NOS1, NOS2, NOS3, HBA2
4	transforming growth factor beta binding	GO:050431	10.5	THBS1, ACVRL1, ENG, ITGAV, CD36, TGFBR3
5	oxygen binding	GO:019825	10.4	HBD, HBG2, HBG1, HBB, HBA2, CYP2C19
6	iron ion binding	GO:005506	10.4	HBA2, NOS3, NOS2, HBG2, NOS1, CYP2D6
7	integrin binding	GO:005178	10.2	ADAMTS13, IGF1, VWF, VCAM1, ICAM4, ITGB1
8	heparin binding	GO:008201	10.0	PF4, THBS1, PGF, TGFBR3, LTF, CCL5
9	fibronectin binding	GO:001968	9.9	ITGA4, ITGB1, IGFBP3, VEGFA, THBS1
10	hormone activity	GO:005179	9.8	KL, EDN1, HAMP, NPPB, EPO, AGT
11	receptor binding	GO:005102	9.4	NPPB, FGB, FGA, F2, CXCL12, NOS2
12	protein homodimerization activity	GO:042803	9.4	HMOX1, HLA-G, CRP, NOS2, G6PD, SOD1
13	protease binding	GO:002020	9.4	CST3, TNF, F3, INS, ITGB1, SERPINE1
14	growth factor activity	GO:008083	8.0	GDF15, PGF, CSF2, CSF1, CXCL12, PPBP
15	cytokine activity	GO:005125	7.2	CSF3, IL3, VEGFA, BMP4, BMP6, IL1B
16	protein binding	GO:005515	4.2	SELE, FLT1, INS, FGA, IL8, AQP1