MCID: SCK020
MIFTS: 19

Sickle Cell - Hemoglobin D Disease malady

Blood category

Summaries for Sickle Cell - Hemoglobin D Disease

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33MalaCards
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MalaCards: Sickle Cell - Hemoglobin D Disease, also known as hbsd disease, is related to hemoglobin d disease and hemoglobin c disease. An important gene associated with Sickle Cell - Hemoglobin D Disease is HBB (hemoglobin, beta). Affiliated tissues include bone marrow, whole blood and spleen.

Aliases & Classifications for Sickle Cell - Hemoglobin D Disease

Sources:
49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
sickle cell - hemoglobin d disease:
Inheritance: Autosomal recessive; Age of onset: Variable


Aliases & Descriptions:

sickle cell - hemoglobin d disease 49
hbsd disease 49


External Ids:

ICD10 via Orphanet26 D57.2

Related Diseases for Sickle Cell - Hemoglobin D Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sickle Cell - Hemoglobin D Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1hemoglobin d disease10.6
2hemoglobin c disease10.6
3sickle cell - hemoglobin c disease10.6
4acute chest syndrome10.3
5thromboembolism10.3

Graphical network of diseases related to Sickle Cell - Hemoglobin D Disease:



Diseases related to sickle cell - hemoglobin d disease

Clinical Features for Sickle Cell - Hemoglobin D Disease

Drugs & Therapeutics for Sickle Cell - Hemoglobin D Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Sickle Cell - Hemoglobin D Disease

Anatomical Context for Sickle Cell - Hemoglobin D Disease

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33MalaCards
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MalaCards organs/tissues related to Sickle Cell - Hemoglobin D Disease:

33
Bone marrow, Whole blood, Spleen, Brain, Kidney, B cells, Fetal brain

Animal Models for Sickle Cell - Hemoglobin D Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Sickle Cell - Hemoglobin D Disease

Sources:
51PubMed
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Articles related to Sickle Cell - Hemoglobin D Disease:

(show top 50)    (show all 97)
idTitleAuthorsYear
1
Severe proliferative retinopathy is associated with blood hyperviscosity in sickle cell hemoglobin-C disease but not in sickle cell anemia. (23076002)
2013
2
Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. (23409025)
2013
3
Benefits of delayed fetal hemoglobin (HbF) switching in sickle cell disease (SCD): a case report and review of the literature. (23588330)
2013
4
Sickle Cell Disease: quality of life in patients with hemoglobin SS and SC disorders. (24255615)
2013
5
Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease. (23539539)
2013
6
Hemoglobin sickle cell disease in Brazil. (23277594)
2013
7
Autoimmune haemolysis in unexpectedly mild sickle cell/hemoglobin C disease. (23760759)
2013
8
Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline. (23049438)
2012
9
Protective role of hemoglobin and fetal hemoglobin in early kidney disease for children with sickle cell anemia. (21523807)
2011
10
Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. (19050697)
2009
11
Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. (19724057)
2009
12
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. (18667698)
2008
13
Heme degradation and oxidative stress in murine models for hemoglobinopathies: thalassemia, sickle cell disease and hemoglobin C disease. (18262448)
2008
14
Clinical studies with fetal hemoglobin-enhancing agents in sickle cell disease. (15534852)
2004
15
Regional experience with newborn screening for sickle cell disease, other hemoglobinopathies and G6PD deficiency. (16868367)
2003
16
Sickle cell hemoglobin C disease in Saudi Arabia. (12682691)
2003
17
Life-threatening thrombotic thrombocytopenic purpura (TTP) in a patient with sickle cell-hemoglobin C disease. (12923661)
2003
18
Cognitive impairment in children with hemoglobin SS sickle cell disease: relationship to MR imaging findings and hematocrit. (12637286)
2003
19
Splenic function in Omani children with sickle cell disease: correlation with severity index, hemoglobin phenotype, iron status, and alpha-thalassemia trait. (12217195)
2002
20
Bilateral simultaneous retinal arteriolar obstruction in a child with hemoglobin SS sickle cell disease. (11304823)
2001
21
Sickle cell-hemoglobin E disease in an Indian family. (12035368)
2001
22
Stroke in hemoglobin (SD) sickle cell disease with moyamoya: successful hydroxyurea treatment after cerebrovascular bypass surgery. (11264186)
2001
23
Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. (10791557)
2000
24
Acute splenic complications in children with sickle cell-hemoglobin C disease. (9202620)
1997
25
Evolution of a retinal hemorrhage in a patient with sickle cell-hemoglobin C disease. (7639661)
1995
26
Retrospective diagnosis of sickle cell-hemoglobin C disease and parvovirus infection by molecular DNA analysis of postmortem tissue. (8522312)
1995
27
Thrombotic thrombocytopenic purpura associated with sickle cell-hemoglobin C disease. (7973909)
1994
28
Concurrent sickle cell hemoglobin C disease and diabetes mellitus: no added risk of proliferative retinopathy? (7966431)
1994
29
Sickle cell-hemoglobin E disease: clinical findings and implications. (1960615)
1991
30
Sickle-cell hemoglobin C disease in pregnancy: report of a case with review of the literature. (7380681)
1980
31
"Step-off" vertebral body: Gaucher's disease versus sickle cell hemoglobinopathy. (103410)
1979
32
Splenic infarction in sickle cell-hemoglobin C disease. Demonstration by selective splenic arteriogram and scintillation scan. (949192)
1976
33
Severe proliferative retinopathy as the only sign of sickle cell hemoglobin C disease. (1275039)
1976
34
Sickle cell and sickle cell-hemoglobin C disease during pregnancy. (5049901)
1972
35
Fractionation studies of copper in erythrocytes from normal, sickle cell anemia, and hemoglobin C disease. (5423505)
1970
36
THE COEXISTENCE OF ACUTE RHEUMATIC FEVER AND SICKLE CELL-HEMOGLOBIN C DISEASE. (14247521)
1965
37
INTRAERYTHROCYTIC HEMOGLOBIN CRYSTALS IN SICKLE CELL-HEMOGLOBIN C DISEASE. (14267697)
1965
38
SICKLE CELL HEMOGLOBIN D DISEASE IN A NEGRO COLOMBIAN PATIENT. (14295513)
1965
39
SICKLE CELL--HEMOGLOBIN C DISEASE. (14208415)
1964
40
Sickle cell hemoglobin-C disease. Two case reports. (13989386)
1963
41
THE FIRST OBSERVATION OF HOMOZYGOUS HEMOGLOBIN S-ALPHA THALASSEMIA DISEASE AND TWO TYPES OF SICKLE CELL THALASSEMIA DISEASE: (A) SICKLE CELL-ALPHA THALASSEMIA DISEASE, (B) SICKLE CELL-BETA THALASSEMIA DISEASE. (14084634)
1963
42
Roentgenographic and clinical appraisal of sickle cell-hemoglobin C disease. (14491713)
1962
43
Salmonella typhimurium osteomyelitis with sickle cell-hemoglobin C disease: a review and case report. (13785022)
1961
44
Sickle cell hemoglobin-C disease treated by splenectomy. (13835649)
1960
45
Pulmonary infarction and atrophy of the spleen associated with sickle-cell hemoglobin C disease. (13657308)
1959
46
Sickle cell-hemoglobin C disease and pregnancy, including a case of osteomyelitis. (13649807)
1959
47
Pregnancy in sickle cell, anemia, sickle cell-hemoglobin C disease, and variants thereof. (13649805)
1959
48
Vitreous hemorrhage associated with sickle-cell trait and sickle-cell hemoglobin-C disease. (13533498)
1958
49
Vitreous hemorrhages associated with sickle cell-hemoglobin C disease. (13372691)
1956
50
Splenic infarction in a patient with sickle-cell-hemoglobin-c disease; report of a case occurring following air travel. (13354018)
1956

Genetic Variations for Sickle Cell - Hemoglobin D Disease

Expression for genes affiliated with Sickle Cell - Hemoglobin D Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sickle Cell - Hemoglobin D Disease

Search GEO for disease gene expression data for Sickle Cell - Hemoglobin D Disease.

Pathways for genes affiliated with Sickle Cell - Hemoglobin D Disease

Compounds for genes affiliated with Sickle Cell - Hemoglobin D Disease

GO Terms for genes affiliated with Sickle Cell - Hemoglobin D Disease

Products for genes affiliated with Sickle Cell - Hemoglobin D Disease

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Sources for Sickle Cell - Hemoglobin D Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet