MCID: SDR002
MIFTS: 44

Siderosis malady

Categories: Rare diseases, Respiratory diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Siderosis

Aliases & Descriptions for Siderosis:

Name: Siderosis 12 50 52 42 14 69
Pulmonary Siderosis 12
Deposition of Iron 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10328
ICD10 33 J63.4
MeSH 42 D012806
UMLS 69 C0037061

Summaries for Siderosis

MalaCards based summary : Siderosis, also known as pulmonary siderosis, is related to superficial siderosis and superficial siderosis of the central nervous system. An important gene associated with Siderosis is HFE (Hemochromatosis), and among its related pathways/superpathways are Vesicle-mediated transport and Insulin receptor recycling. The drugs Iron and Interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related phenotype is liver/biliary system.

Wikipedia : 71 Siderosis is the deposition of iron in... more...

Related Diseases for Siderosis

Diseases in the Siderosis family:

Siderosis of Eye

Diseases related to Siderosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
id Related Disease Score Top Affiliating Genes
1 superficial siderosis 12.2
2 superficial siderosis of the central nervous system 12.2
3 siderosis of eye 11.8
4 iron overload in africa 11.7
5 interstitial lung disease 11.1
6 hemochromatosis, neonatal 10.8
7 cardiomyopathy, dilated, 1g 10.3 FTH1 TF
8 dermatoleukodystrophy 10.2 HFE TF
9 hepatitis 10.2
10 handl syndrome 10.2 LTF TF
11 benign idiopathic neonatal seizures 10.2 LTF TF
12 harp syndrome 10.2 HFE TF
13 cerebritis 10.2
14 glycogen storage disease ixa 10.2 HFE SLC40A1
15 choriodal dystrophy, central areolar 2 10.2 SERPINA1 TF
16 poems syndrome 10.2 TF TFRC
17 sutton disease 2 10.1 FTH1 LTF TF
18 muscular dystrophy, congenital, 1b 10.1 HFE UROD
19 rosette-forming glioneuronal tumor of fourth ventricule 10.1 FTH1 LTF TF
20 achilles bursitis 10.1 SERPINA1 TF
21 cerebral amyloid angiopathy 10.1
22 chondrosarcoma, extraskeletal myxoid 10.1 SERPINA1 TF
23 epileptic encephalopathy, early infantile, 13 10.1 HBB TF
24 peroxisome biogenesis disorder 12a 10.1 HFE UROD
25 hemochromatosis 10.1
26 ivic syndrome 10.1 SERPINA1 TF
27 acanthosis nigricans 10.1 HFE UROD
28 intestinal tuberculosis 10.1 HFE TF UROD
29 spastic entropion 10.1 LTF TF
30 neurilemmoma of the pleura 10.0 TF TFRC
31 cat-scratch disease 10.0 TF TFRC
32 thalassemia 10.0
33 posterior uveal melanoma 10.0 HFE SERPINA1 TF
34 lymphoblastic lymphoma 10.0 HFE SERPINA1 TF
35 episcleritis periodica fugax 10.0 HBB HFE TF
36 larynx sarcoma 10.0 HBB HFE TF
37 lymphoid leukemia 10.0 HFE SERPINA1 TF
38 thalassemia major 10.0
39 sensorineural hearing loss 9.9
40 fanconi anemia, complementation group c 9.9 SERPINA1 TF
41 blind hypotensive eye 9.9 HFE LTF TF TFRC
42 vagus nerve neoplasm 9.9 HBB HFE TFRC
43 mandibuloacral dysplasia with type b lipodystrophy 9.9 HFE TF TFRC UROD
44 ependymoma 9.9
45 aarskog-scott syndrome 9.9 HBB SLC40A1 TFRC
46 post-thrombotic syndrome 9.9 HFE SLC40A1 TF TFRC
47 esophageal leukoplakia 9.9 HFE SLC40A1 TF TFRC
48 facial paresis, hereditary congenital, 1 9.9 HFE SLC40A1 TF TFRC
49 meningitis 9.8
50 ataxia 9.8

Graphical network of the top 20 diseases related to Siderosis:



Diseases related to Siderosis

Symptoms & Phenotypes for Siderosis

MGI Mouse Phenotypes related to Siderosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 FTH1 HFE LTF SLC40A1 TFRC UROD

Drugs & Therapeutics for Siderosis

Drugs for Siderosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2,Phase 3 7439-89-6 23925
2
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
3
Deferiprone Approved Phase 4,Phase 2,Phase 3 30652-11-0 2972
4 Liver Extracts Phase 4
5 Micronutrients Phase 4
6 Trace Elements Phase 4
7 Adjuvants, Immunologic Phase 4
8 Anti-Infective Agents Phase 4
9 Antiviral Agents Phase 4
10 Interferon-beta Phase 4
11 interferons Phase 4
12 Chelating Agents Phase 4,Phase 2,Phase 3
13 Iron Chelating Agents Phase 4,Phase 2,Phase 3
14
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
15
Deferasirox Approved, Investigational Phase 2, Phase 3 201530-41-8 5493381
16
Deferoxamine Approved, Investigational Phase 2, Phase 3 70-51-9 2973
17 Protective Agents Phase 3,Phase 2
18 Antihypertensive Agents Phase 2, Phase 3
19 calcium channel blockers Phase 2, Phase 3
20 Calcium, Dietary Phase 2, Phase 3,Phase 1
21 Vasodilator Agents Phase 2, Phase 3
22 Antioxidants Phase 3
23
Epigallocatechin gallate Phase 3 989-51-5 65064
24 Neuroprotective Agents Phase 3
25
Epigallocatechin Experimental, Nutraceutical Phase 3 970-74-1 72277
26
Mitoxantrone Approved, Investigational Phase 2 65271-80-9 4212
27
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
28 Analgesics Phase 2
29 Antimitotic Agents Phase 2
30 Peripheral Nervous System Agents Phase 2
31 razoxane Phase 2
32 Topoisomerase Inhibitors Phase 2
33 Anticholesteremic Agents Phase 1, Phase 2
34 Antimetabolites Phase 1, Phase 2
35 Atorvastatin Calcium Phase 1, Phase 2 134523-03-8
36 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
37 Hypolipidemic Agents Phase 1, Phase 2
38 Lipid Regulating Agents Phase 1, Phase 2
39 Pharmaceutical Solutions Phase 2
40 Antimetabolites, Antineoplastic Phase 2
41
Glatiramer Acetate Approved, Investigational 147245-92-9 3081884
42
Pancrelipase Approved 53608-75-6
43
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757 53477783
44
Methyltestosterone Approved 58-18-4 6010
45
Testosterone Approved, Investigational 58-22-0 6013
46
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
47 Antirheumatic Agents
48 Immunosuppressive Agents
49 Gastrointestinal Agents
50 pancreatin

Interventional clinical trials:

(show all 27)
id Name Status NCT ID Phase
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial Completed NCT01085318 Phase 4
3 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Active, not recruiting NCT01284127 Phase 4
4 Amlodipine for Myocardial Iron in Thalassemia Completed NCT02065492 Phase 2, Phase 3
5 Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach Completed NCT02008721 Phase 3
6 Study to Evaluate the Reduction of Cardiac Problems in Multiple Sclerosis Patients With Mitoxantrone and Dexrazoxane in Combination Unknown status NCT01627938 Phase 2
7 Atorvastatin Therapy in Cerebral Cavernous Malformation, Exploratory Proof of Concept Trial Not yet recruiting NCT02603328 Phase 1, Phase 2
8 Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome Terminated NCT01892644 Phase 2
9 Azacitidine Plus Deferasirox (ICL670) in Higher Risk Myelodysplastic Syndromes (MDS) Terminated NCT02038816 Phase 2
10 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
11 Multi-Center Study of Iron Overload: Survey Study (MCSIO) Unknown status NCT01913548
12 Multi-Center Study of Iron Overload: Pilot Study Unknown status NCT01114776
13 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
14 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
15 A Longitudinal Study of Effect of Copaxone in RRMS Over 24 Months Completed NCT01695434
16 T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients Completed NCT00520559
17 Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia Completed NCT00972231
18 MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. Completed NCT00629291
19 Magnetic Resonance Imaging Study of Acute Pancreatitis Completed NCT01911689
20 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Recruiting NCT02527330
21 Reproductive Capacity and Iron Burden in Thalassemia Recruiting NCT02308904
22 Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders Recruiting NCT02836327
23 Noninvasive Staging of Liver Fibrosis: MR vs Ultrasound Recruiting NCT02044523
24 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
25 A Case Control Study to Evaluate the Cognitive and Brain Function of β-thalassemia Patients. Enrolling by invitation NCT01935661
26 Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis Not yet recruiting NCT02664571
27 Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes Terminated NCT02445469

Search NIH Clinical Center for Siderosis

Cochrane evidence based reviews: siderosis

Genetic Tests for Siderosis

Anatomical Context for Siderosis

MalaCards organs/tissues related to Siderosis:

39
Liver, Brain, Lung, Bone, Pituitary, Heart, Testes

Publications for Siderosis

Articles related to Siderosis:

(show top 50) (show all 588)
id Title Authors Year
1
Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. ( 28356458 )
2017
2
Characterizing Deep White Matter Hyperintensities in Patients with Symptomatic Isolated Cortical Superficial Siderosis. ( 28089561 )
2017
3
Diagnosis and quantification of fibrosis, steatosis, and hepatic siderosis through multiparametric magnetic resonance imaging. ( 28089429 )
2017
4
Sepsis and siderosis, Yersinia enterocolitica and hereditary haemochromatosis. ( 28052950 )
2017
5
Superficial siderosis and dural ectasia: A case report. ( 27754910 )
2016
6
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. ( 27356733 )
2016
7
Superficial Siderosis after Germinal Matrix Hemorrhage. ( 27633808 )
2016
8
IV and V cranial nerves dysfunction as initial manifestations of superficial siderosis of the central nervous system. ( 26988173 )
2016
9
Duodenal siderosis: a rare clinical finding in a patient with duodenal inflammation. ( 27366043 )
2016
10
Chronic dorsal subdural haematoma: single aetiology for CNS superficial siderosis and myelopathy. ( 27055529 )
2016
11
Deferiprone Reduces Hemosiderin Deposition in Superficial Siderosis. ( 27788692 )
2016
12
Cerebral Microhemorrhages and Meningeal Siderosis in Infective Endocarditis. ( 27871078 )
2016
13
Sporadic cerebral amyloid angiopathy as a cause of relapsing lobar hemorrhage, convexal subarachnoid hemorrhage and cortical superficial siderosis. ( 27259571 )
2016
14
Ocular Siderosis Subsequent to a Missed Pars Plana Metallic Foreign Body that Masqueraded as Refractory Intermediate Uveitis. ( 27849408 )
2016
15
Case report: Superficial siderosis after brachial plexus avulsion. ( 26914142 )
2016
16
Spinal subarachnoid hemorrhage in cortical superficial siderosis after apixaban and clopidogrel therapy. ( 26837378 )
2016
17
Superficial Siderosis. ( 27685823 )
2016
18
Burden of Cardiac Siderosis in a Thalassemia-Major Endemic Population: A Preliminary Report From Pakistan. ( 27164519 )
2016
19
Cochlear implantation is a therapeutic option for superficial siderosis patients with sensorineural hearing loss. ( 26857965 )
2016
20
Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population. ( 27534713 )
2016
21
Superficial siderosis associated with peripheral autonomic failure and tetraventricular hydrocephalus: a case report. ( 27498096 )
2016
22
Cortical superficial siderosis predicts early recurrent lobar hemorrhage. ( 27694268 )
2016
23
Intraspinal hemorrhage in spontaneous intracranial hypotension: link to superficial siderosis? Report of 2 cases. ( 26588500 )
2016
24
Management of Ocular Siderosis: Visual Outcome and Electroretinographic Changes. ( 27073692 )
2016
25
Gastric siderosis: An under-recognized and rare clinical entity. ( 26985391 )
2016
26
Gastric siderosis as a cause of dyspepsia. ( 27511759 )
2016
27
Pituitary siderosis: the dark side of the pituitary. ( 26776860 )
2016
28
An autopsy case of cortical superficial siderosis with persistent abnormal behavior. ( 27090856 )
2016
29
Cortical Superficial Siderosis Presumed due to Cerebral Amyloid Angiopathy: Minimum Standards for Rating and Reporting. ( 26915571 )
2016
30
Corticobasal Syndrome Due to Superficial Siderosis Caused by Thalamic Cavernoma. ( 26844964 )
2016
31
Cerebral Amyloid Angiopathy as an Etiology for Cortical Superficial Siderosis: An Unproven Hypothesis. ( 26721767 )
2016
32
Cerebrospinal Fluid Alzheimer's Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis. ( 27567848 )
2016
33
Aneurysmal wall imaging in a case of cortical superficial siderosis and multiple unruptured aneurysms. ( 27873743 )
2016
34
Familial amyloid polyneuropathy involving a homozygous Val30Met mutation in the amyloidogenic transthyretin gene presenting with superficial siderosis: a case report. ( 27212678 )
2016
35
The value of eZIS analysis of Tc-99m ECD SPECT on identifying cerebellar hypoperfusion in a patient with superficial siderosis: A case report. ( 27893680 )
2016
36
Infratentorial superficial siderosis: Classification, diagnostic criteria and rational investigation pathway. ( 28019651 )
2016
37
Liver Failure, Hepatic Siderosis, and Membrane Attack Complexes: Neonatal Hemochromatosis and/or Galactosemia?: RETRACTED. ( 27403610 )
2016
38
Cerebral Microbleeds and Cortical Superficial Siderosis in Patients Presenting With Minor Cerebrovascular Events. ( 27507863 )
2016
39
Cortical Superficial Siderosis in Memory Clinic Patients: Further Evidence for Underlying Cerebral Amyloid Angiopathy. ( 26751369 )
2016
40
Superficial siderosis syndrome with progressive hearing loss and bilateral vestibular failure, 51 years after a neurosurgical procedure: diagnostic value of combined MRI and video head impulse test. ( 27981351 )
2016
41
Intracranial dural arteriovenous fistula as a cause for symptomatic superficial siderosis: A report of two cases and review of the literature. ( 27127712 )
2016
42
Sequential Bilateral Non-Arteritic Anterior Ischaemic Optic Neuropathy in Superficial Intracranial Siderosis. ( 27116492 )
2016
43
Superficial siderosis complicated by hydrocephalus: bleeding from the dura mater in the cerebrospinal fluid cavity after brain tumor surgery. ( 27117905 )
2016
44
Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report. ( 27437021 )
2016
45
Interstitial Lung Disease due to Siderosis in a Lathe Machine Worker. ( 26410982 )
2015
46
Resolution of siderosis glaucoma from chronic intraocular foreign body without glaucoma surgery. ( 26455988 )
2015
47
The Characteristics of Superficial Siderosis and Convexity Subarachnoid Hemorrhage and Clinical Relevance in Suspected Cerebral Amyloid Angiopathy. ( 25871492 )
2015
48
Cochlear Implantation in Patients With Superficial Siderosis: Seven Cases and Systematic Review of the Literature. ( 26065403 )
2015
49
Effect of inversion recovery fat suppression on hepatic R2* quantitation in transfusional siderosis. ( 25714295 )
2015
50
Bilateral Vestibulopathy Documented by Video Head Impulse Tests in Superficial Siderosis. ( 26440725 )
2015

Variations for Siderosis

Expression for Siderosis

Search GEO for disease gene expression data for Siderosis.

Pathways for Siderosis

GO Terms for Siderosis

Cellular components related to Siderosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 FTH1 HBB LTF SERPINA1 TF TFRC
2 extracellular space GO:0005615 9.63 HBB HFE LTF SERPINA1 TF TFRC
3 blood microparticle GO:0072562 9.58 HBB TF TFRC
4 ficolin-1-rich granule lumen GO:1904813 9.5 FTH1 HBB SERPINA1
5 clathrin-coated vesicle membrane GO:0030665 9.46 TF TFRC
6 recycling endosome GO:0055037 9.43 HFE TF TFRC
7 basal part of cell GO:0045178 9.37 HFE TF
8 tertiary granule lumen GO:1904724 9.13 FTH1 HBB LTF
9 HFE-transferrin receptor complex GO:1990712 8.8 HFE TF TFRC

Biological processes related to Siderosis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.81 HFE LTF SLC40A1 TF
2 neutrophil degranulation GO:0043312 9.76 FTH1 HBB LTF SERPINA1
3 cellular protein metabolic process GO:0044267 9.65 LTF SERPINA1 TF
4 retina homeostasis GO:0001895 9.52 LTF TF
5 acute-phase response GO:0006953 9.49 HFE SERPINA1
6 positive regulation of receptor-mediated endocytosis GO:0048260 9.43 HFE TF
7 transferrin transport GO:0033572 9.43 HFE TF TFRC
8 multicellular organismal iron ion homeostasis GO:0060586 9.4 HFE SLC40A1
9 cellular response to iron ion GO:0071281 9.37 HFE TF
10 iron ion transport GO:0006826 9.33 FTH1 SLC40A1 TF
11 iron ion import GO:0097286 9.32 FTH1 TFRC
12 iron ion homeostasis GO:0055072 9.26 HFE LTF SLC40A1 TF
13 cellular iron ion homeostasis GO:0006879 9.1 FTH1 HFE ISCU SLC40A1 TF TFRC

Molecular functions related to Siderosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glycoprotein binding GO:0001948 9.37 SERPINA1 TFRC
2 ferrous iron binding GO:0008198 9.26 ISCU TF
3 ferric iron binding GO:0008199 9.16 FTH1 TF
4 transferrin receptor binding GO:1990459 8.96 HFE TF
5 iron ion binding GO:0005506 8.92 FTH1 HBB ISCU LTF
6 protein binding GO:0005515 10.02 FTH1 HBB HFE ISCU LTF SERPINA1

Sources for Siderosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....