MCID: SDR002
MIFTS: 44

Siderosis

Categories: Rare diseases, Respiratory diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Siderosis

MalaCards integrated aliases for Siderosis:

Name: Siderosis 12 50 52 42 14 69
Pulmonary Siderosis 12
Deposition of Iron 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10328
ICD10 33 J63.4
MeSH 42 D012806
UMLS 69 C0037061

Summaries for Siderosis

MalaCards based summary : Siderosis, also known as pulmonary siderosis, is related to porphyria cutanea tarda and superficial siderosis. An important gene associated with Siderosis is HFE (Hemochromatosis), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Vesicle-mediated transport. The drugs Iron and Interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and heart, and related phenotype is liver/biliary system.

Wikipedia : 72 Siderosis is the deposition of iron in... more...

Related Diseases for Siderosis

Diseases in the Siderosis family:

Siderosis of Eye

Diseases related to Siderosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
id Related Disease Score Top Affiliating Genes
1 porphyria cutanea tarda 29.5 HFE TF TFRC UROD
2 superficial siderosis 12.2
3 superficial siderosis of the central nervous system 12.2
4 siderosis of eye 11.8
5 iron overload in africa 11.6
6 interstitial lung disease 11.1
7 hemochromatosis, neonatal 10.8
8 dermatoosteolysis, kirghizian type 10.6 HFE TF
9 harp syndrome 10.6 HFE TF
10 glycogen storage disease ixa 10.5 HFE SLC40A1
11 poems syndrome 10.5 TF TFRC
12 multiple symmetrical lipomatosis 10.5 HFE UROD
13 distal arthrogryposis 10.5 HBB TF
14 porphyria variegata 10.5 HFE UROD
15 posterior foramen magnum meningioma 10.4 TF TFRC
16 rhizomelic chondrodysplasia punctata, type 2 10.4 HFE UROD
17 superior vena cava syndrome 10.3 FTH1 TF
18 cardiomyopathy, dilated, 1g 10.3 FTH1 TF
19 intestinal tuberculosis 10.3 HFE TF UROD
20 hepatitis 10.2
21 blind hypotensive eye 10.2 HFE TF TFRC
22 mediastinum leiomyoma 10.2 TF TFRC
23 cerebritis 10.2
24 endometrial adenocarcinoma 10.2 HBB HFE TF
25 cat-scratch disease 10.2 TF TFRC
26 cerebral amyloid angiopathy 10.1
27 hemochromatosis 10.1
28 hemoglobin h disease, nondeletional 10.1 HBB HFE
29 macular dystrophy, patterned, 1 10.1 SERPINA1 TF
30 lacrimal system cancer 10.1 HBB TF TFRC
31 achilles bursitis 10.1 SERPINA1 TF
32 myasthenic syndrome, congenital, 14, with tubular aggregates 10.0 SERPINA1 TF
33 thalassemia 10.0
34 aarskog-scott syndrome 10.0 HBB SLC40A1 TFRC
35 mental retardation, x-linked, syndromic 15 10.0 SERPINA1 TF
36 thalassemia major 10.0
37 sensorineural hearing loss 9.9
38 ependymoma 9.9
39 anal fistula 9.9 HFE SERPINA1
40 spinal muscular atrophy, lower extremity-predominant, 2, ad 9.9 SERPINA1 TF
41 meningitis 9.9
42 post-thrombotic syndrome 9.9 HFE SLC40A1 TF TFRC
43 narcolepsy 9.9 HFE SLC40A1 TF TFRC
44 episcleritis periodica fugax 9.9 HFE SLC40A1 TF TFRC
45 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.9 HFE SLC40A1 TF TFRC
46 cervicitis 9.9
47 ataxia 9.9
48 sleep disorder 9.8 SERPINA1 TF
49 mycobacterium kansasii 9.8 HMOX1 SERPINA1
50 pituicytoma 9.8 FTH1 HMOX1 TF

Graphical network of the top 20 diseases related to Siderosis:



Diseases related to Siderosis

Symptoms & Phenotypes for Siderosis

MGI Mouse Phenotypes related to Siderosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.1 FTH1 HFE HMOX1 SLC40A1 TFRC UROD

Drugs & Therapeutics for Siderosis

Drugs for Siderosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2,Phase 3 7439-89-6 23925
2
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
3 Liver Extracts Phase 4
4 interferons Phase 4
5 Adjuvants, Immunologic Phase 4
6 Micronutrients Phase 4
7 Trace Elements Phase 4
8 Anti-Infective Agents Phase 4
9 Interferon-beta Phase 4
10 Antiviral Agents Phase 4
11
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
12
Deferoxamine Approved, Investigational Phase 2, Phase 3 70-51-9 2973
13
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
14
Deferasirox Approved, Investigational Phase 2, Phase 3 201530-41-8 5493381
15
Epigallocatechin gallate Investigational Phase 3 989-51-5 65064
16 Protective Agents Phase 3,Phase 2
17 calcium channel blockers Phase 2, Phase 3
18 Chelating Agents Phase 2, Phase 3
19 Neuroprotective Agents Phase 3
20 Vasodilator Agents Phase 2, Phase 3
21 Iron Chelating Agents Phase 2, Phase 3
22 Antihypertensive Agents Phase 2, Phase 3
23 Calcium, Dietary Phase 2, Phase 3,Phase 1
24 Antioxidants Phase 3
25
Epigallocatechin Experimental, Nutraceutical Phase 3 970-74-1 72277
26
Mitoxantrone Approved, Investigational Phase 2 65271-80-9 4212
27
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
28 razoxane Phase 2
29 Analgesics Phase 2
30 Topoisomerase Inhibitors Phase 2
31 Peripheral Nervous System Agents Phase 2
32 Antimitotic Agents Phase 2
33 Atorvastatin Calcium Phase 1, Phase 2 134523-03-8
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
35 Hypolipidemic Agents Phase 1, Phase 2
36 Anticholesteremic Agents Phase 1, Phase 2
37 Lipid Regulating Agents Phase 1, Phase 2
38 Antimetabolites Phase 1, Phase 2
39 Pharmaceutical Solutions Phase 2
40 Antimetabolites, Antineoplastic Phase 2
41
Glatiramer Acetate Approved, Investigational 147245-92-9 3081884
42
Pancrelipase Approved 53608-75-6
43
Testosterone Approved, Investigational 58-22-0 6013
44
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
45 Tocopherol Approved, Nutraceutical
46
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
47 pancreatin
48 Gastrointestinal Agents
49 Immunosuppressive Agents
50 Antirheumatic Agents

Interventional clinical trials:

(show all 27)

id Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial Completed NCT01085318 Phase 4 Rebif
3 Amlodipine for Myocardial Iron in Thalassemia Completed NCT02065492 Phase 2, Phase 3 Standard Chelation;Amlodipine
4 Progression Rate of MSA Under EGCG Supplementation as Anti-Aggregation-Approach Completed NCT02008721 Phase 3 EGCG as putative neuroprotective agent;Placebo
5 Study to Evaluate the Reduction of Cardiac Problems in Multiple Sclerosis Patients With Mitoxantrone and Dexrazoxane in Combination Unknown status NCT01627938 Phase 2 Dexrazoxane (DRZ) plus Mitoxantrone (MX);Placebo plus Mitoxantrone (MX)
6 Atorvastatin Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial Not yet recruiting NCT02603328 Phase 1, Phase 2 Atorvastatin
7 Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome Terminated NCT01892644 Phase 2 Deferasirox;Deferasirox
8 Azacitidine Plus Deferasirox (ICL670) in Higher Risk Myelodysplastic Syndromes (MDS) Terminated NCT02038816 Phase 2 Deferasirox + Azacitidine;Azacitidine
9 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
10 Multi-Center Study of Iron Overload: Survey Study (MCSIO) Unknown status NCT01913548
11 Multi-Center Study of Iron Overload: Pilot Study Unknown status NCT01114776
12 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
13 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
14 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
15 A Longitudinal Study of Effect of Copaxone in RRMS Over 24 Months Completed NCT01695434
16 T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients Completed NCT00520559
17 Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia Completed NCT00972231
18 MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. Completed NCT00629291
19 Magnetic Resonance Imaging Study of Acute Pancreatitis Completed NCT01911689
20 Reproductive Capacity and Iron Burden in Thalassemia Recruiting NCT02308904
21 Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders Recruiting NCT02836327
22 Noninvasive Staging of Liver Fibrosis: MR vs Ultrasound Recruiting NCT02044523
23 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Active, not recruiting NCT01284127
24 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
25 A Case Control Study to Evaluate the Cognitive and Brain Function of β-thalassemia Patients. Enrolling by invitation NCT01935661
26 Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis Not yet recruiting NCT02664571
27 Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes Terminated NCT02445469

Search NIH Clinical Center for Siderosis

Cochrane evidence based reviews: siderosis

Genetic Tests for Siderosis

Anatomical Context for Siderosis

MalaCards organs/tissues related to Siderosis:

39
Liver, Brain, Heart, Pancreas, Lung, Bone, Pituitary

Publications for Siderosis

Articles related to Siderosis:

(show top 50) (show all 603)
id Title Authors Year
1
Rare association of secondary superficial siderosis caused by a fourth ventricle hemorrhagic ependymoma mimicking a cavernoma: Case report and literature review. ( 28217393 )
2017
2
Intradural extramedullary cavernous malformation with extensive superficial siderosis of the neuraxis: Case report and review of literature. ( 28680728 )
2017
3
Teaching NeuroImages: Superficial siderosis due to a dural cervical arteriovenous fistula. ( 28220016 )
2017
4
Recurrent Focal Neurological Symptoms and Cortical Siderosis. ( 28400907 )
2017
5
Cortical Superficial Siderosis in Different Types of Cerebral Small Vessel Disease. ( 28364025 )
2017
6
Stroke: Cortical superficial siderosis absent in CADASIL. ( 28452354 )
2017
7
Case Report: A Comprehensive Neuropsychological Assessment of a Case of Superficial Siderosis. ( 28158476 )
2017
8
Aneurysmal wall imaging in a case of cortical superficial siderosis and multiple unruptured aneurysms. ( 28559509 )
2017
9
Superficial siderosis presenting as chronic migraine: Rare presentation of a rare disease. ( 28298848 )
2017
10
Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy. ( 28356458 )
2017
11
Spinal meningeal diverticula, spontaneous intracranial hypotension, and superficial siderosis. ( 28130464 )
2017
12
Superficial siderosis of the central nervous system is a rare and possibly underdiagnosed disorder. ( 28226077 )
2017
13
Diagnosis and quantification of fibrosis, steatosis, and hepatic siderosis through multiparametric magnetic resonance imaging. ( 28089429 )
2017
14
Superficial siderosis of the central nervous system associated with intraspinal hemorrhage from ventral thoracic epidural veins and a ventral spinal CSF leak: case report. ( 28338451 )
2017
15
Characterizing Deep White Matter Hyperintensities in Patients with Symptomatic Isolated Cortical Superficial Siderosis. ( 28089561 )
2017
16
A case of superficial siderosis ameliorated after closure of dural deficit detected by MRI-CISS (constructive interference in steady state) imaging. ( 28367945 )
2017
17
Sepsis and siderosis, Yersinia enterocolitica and hereditary haemochromatosis. ( 28052950 )
2017
18
Erratum: Rare association of secondary superficial siderosis caused by a fourth ventricle hemorrhagic ependymoma mimicking a cavernoma: Case report and literature review. ( 28540135 )
2017
19
Isolated spinal cord compression syndrome revealing delayed extensive superficial siderosis of the central nervous system secondary to cervical root avulsion. ( 28580859 )
2017
20
Sequential Bilateral Non-Arteritic Anterior Ischaemic Optic Neuropathy in Superficial Intracranial Siderosis. ( 27116492 )
2016
21
Deferiprone Reduces Hemosiderin Deposition in Superficial Siderosis. ( 27788692 )
2016
22
Superficial siderosis complicated by hydrocephalus: bleeding from the dura mater in the cerebrospinal fluid cavity after brain tumor surgery. ( 27117905 )
2016
23
Pituitary siderosis: the dark side of the pituitary. ( 26776860 )
2016
24
Cerebral Microbleeds and Cortical Superficial Siderosis in Patients Presenting With Minor Cerebrovascular Events. ( 27507863 )
2016
25
Familial amyloid polyneuropathy involving a homozygous Val30Met mutation in the amyloidogenic transthyretin gene presenting with superficial siderosis: a case report. ( 27212678 )
2016
26
Case report: Superficial siderosis after brachial plexus avulsion. ( 26914142 )
2016
27
Gastric siderosis as a cause of dyspepsia. ( 27511759 )
2016
28
The value of eZIS analysis of Tc-99m ECD SPECT on identifying cerebellar hypoperfusion in a patient with superficial siderosis: A case report. ( 27893680 )
2016
29
Intraspinal hemorrhage in spontaneous intracranial hypotension: link to superficial siderosis? Report of 2 cases. ( 26588500 )
2016
30
Cortical Superficial Siderosis Presumed due to Cerebral Amyloid Angiopathy: Minimum Standards for Rating and Reporting. ( 26915571 )
2016
31
Intracranial dural arteriovenous fistula as a cause for symptomatic superficial siderosis: A report of two cases and review of the literature. ( 27127712 )
2016
32
Cortical Superficial Siderosis in Memory Clinic Patients: Further Evidence for Underlying Cerebral Amyloid Angiopathy. ( 26751369 )
2016
33
Infratentorial superficial siderosis: Classification, diagnostic criteria and rational investigation pathway. ( 28019651 )
2016
34
Corticobasal Syndrome Due to Superficial Siderosis Caused by Thalamic Cavernoma. ( 26844964 )
2016
35
Cortical superficial siderosis predicts early recurrent lobar hemorrhage. ( 27694268 )
2016
36
Management of Ocular Siderosis: Visual Outcome and Electroretinographic Changes. ( 27073692 )
2016
37
Superficial Siderosis of the Central Nervous System Originating from the Thoracic Spine: A Case Report. ( 27437021 )
2016
38
Liver Failure, Hepatic Siderosis, and Membrane Attack Complexes: Neonatal Hemochromatosis and/or Galactosemia?: RETRACTED. ( 27403610 )
2016
39
Chronic dorsal subdural haematoma: single aetiology for CNS superficial siderosis and myelopathy. ( 27055529 )
2016
40
Cerebral Amyloid Angiopathy as an Etiology for Cortical Superficial Siderosis: An Unproven Hypothesis. ( 26721767 )
2016
41
An autopsy case of superficial siderosis of the central nervous system accompanied by anterior sacral polycystic meningocele in neurofibromatosis type 1. ( 27356733 )
2016
42
Superficial siderosis and dural ectasia: A case report. ( 27754910 )
2016
43
Burden of Cardiac Siderosis in a Thalassemia-Major Endemic Population: A Preliminary Report From Pakistan. ( 27164519 )
2016
44
Spinal subarachnoid hemorrhage in cortical superficial siderosis after apixaban and clopidogrel therapy. ( 26837378 )
2016
45
An autopsy case of cortical superficial siderosis with persistent abnormal behavior. ( 27090856 )
2016
46
Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population. ( 27534713 )
2016
47
Ocular Siderosis Subsequent to a Missed Pars Plana Metallic Foreign Body that Masqueraded as Refractory Intermediate Uveitis. ( 27849408 )
2016
48
Duodenal siderosis: a rare clinical finding in a patient with duodenal inflammation. ( 27366043 )
2016
49
Superficial Siderosis. ( 27685823 )
2016
50
Cerebral Microhemorrhages and Meningeal Siderosis in Infective Endocarditis. ( 27871078 )
2016

Variations for Siderosis

Expression for Siderosis

Search GEO for disease gene expression data for Siderosis.

Pathways for Siderosis

Pathways related to Siderosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 FTH1 HMOX1 SLC40A1 TF TFRC
2
Show member pathways
12.94 FTH1 HBB SERPINA1 TF TFRC
3 12.12 FTH1 HBB HMOX1
4
Show member pathways
12.1 FTH1 HMOX1 SLC40A1 TF TFRC
5 11.74 FTH1 HMOX1 SERPINA1
6 11.54 HMOX1 TF TFRC
7 11.31 HMOX1 TF TFRC
8 11.16 FTH1 HMOX1 SLC40A1 TF
9 10.62 FTH1 HMOX1 SLC40A1 TF TFRC
10 10.34 FTH1 SLC40A1 TF TFRC

GO Terms for Siderosis

Cellular components related to Siderosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 HBB HFE HMOX1 SERPINA1 TF TFRC
2 perinuclear region of cytoplasm GO:0048471 9.71 HFE HMOX1 TF TFRC
3 blood microparticle GO:0072562 9.54 HBB TF TFRC
4 tertiary granule lumen GO:1904724 9.46 FTH1 HBB
5 clathrin-coated vesicle membrane GO:0030665 9.43 TF TFRC
6 ficolin-1-rich granule lumen GO:1904813 9.33 FTH1 HBB SERPINA1
7 basal part of cell GO:0045178 9.26 HFE TF
8 recycling endosome GO:0055037 9.13 HFE TF TFRC
9 HFE-transferrin receptor complex GO:1990712 8.8 HFE TF TFRC

Biological processes related to Siderosis according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 9.51 HBB HMOX1
2 transferrin transport GO:0033572 9.5 HFE TF TFRC
3 acute-phase response GO:0006953 9.49 HFE SERPINA1
4 liver regeneration GO:0097421 9.48 HFE HMOX1
5 positive regulation of receptor-mediated endocytosis GO:0048260 9.46 HFE TF
6 multicellular organismal iron ion homeostasis GO:0060586 9.43 HFE SLC40A1
7 cellular response to iron ion GO:0071281 9.4 HFE TF
8 heme metabolic process GO:0042168 9.37 HMOX1 UROD
9 iron ion transport GO:0006826 9.33 FTH1 SLC40A1 TF
10 regulation of transcription from RNA polymerase II promoter in response to iron GO:0034395 9.26 HMOX1 SLC40A1
11 iron ion homeostasis GO:0055072 9.26 HFE HMOX1 SLC40A1 TF
12 cellular iron ion homeostasis GO:0006879 9.17 FTH1 HFE HMOX1 ISCU SLC40A1 TF

Molecular functions related to Siderosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.33 FTH1 HBB ISCU
2 ferrous iron binding GO:0008198 9.26 ISCU TF
3 ferric iron binding GO:0008199 8.96 FTH1 TF
4 transferrin receptor binding GO:1990459 8.62 HFE TF
5 protein binding GO:0005515 10.02 FTH1 HBB HFE HMOX1 ISCU SERPINA1

Sources for Siderosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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