MCID: SGN002
MIFTS: 43

Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Signet Ring Cell Adenocarcinoma:

Name: Signet Ring Cell Adenocarcinoma 12 14
Carcinoma, Signet Ring Cell 42 69
Signet Ring Cell Carcinoma 12
Carcinoma Signet Ring Cell 52
Signet Ring Carcinoma Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3493
MeSH 42 D018279
NCIt 47 C3774
UMLS 69 C0206696

Summaries for Signet Ring Cell Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which have signet ring appearance.

MalaCards based summary : Signet Ring Cell Adenocarcinoma, also known as carcinoma, signet ring cell, is related to pancreatic signet ring cell adenocarcinoma and gastric signet ring cell adenocarcinoma. An important gene associated with Signet Ring Cell Adenocarcinoma is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Development HGF signaling pathway and Cytoskeletal Signaling. The drugs Oxaliplatin and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and prostate, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Signet Ring Cell Adenocarcinoma

Diseases related to Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
id Related Disease Score Top Affiliating Genes
1 pancreatic signet ring cell adenocarcinoma 27.4 CDH1 CDX2 CHGA CTNNB1 KRT20 KRT7
2 gastric signet ring cell adenocarcinoma 12.4
3 bile duct signet ring cell carcinoma 12.2
4 bladder signet ring cell adenocarcinoma 12.2
5 gallbladder signet ring cell adenocarcinoma 12.2
6 breast signet ring cell adenocarcinoma 12.2
7 prostate signet ring cell adenocarcinoma 12.2
8 ampullary signet ring cell adenocarcinoma 12.1
9 diffuse gastric cancer 11.9
10 gastric cancer risk after h. pylori infection 11.2
11 rectum signet ring adenocarcinoma 11.2
12 ascending colon cancer 10.8 KRT20 MUC2
13 adenocarcinoma 10.8
14 bile duct clear cell adenocarcinoma 10.8 CDX2 MUC2
15 bone giant cell tumor 10.8 KRT20 KRT7
16 rectum adenoma 10.7 KRT20 KRT7
17 steroid-induced glaucoma - borderline 10.7 KRT20 KRT7
18 clear cell squamous cell skin carcinoma 10.7 KRT20 KRT7
19 gastric adenocarcinoma 10.7 CDX2 KRT20
20 vulva squamous cell carcinoma 10.7 KRT20 KRT7
21 angioma serpiginosum 10.7 CDH1 KRT20
22 synovitis 10.7 CDX2 KRT7
23 follicular basal cell carcinoma 10.7 CDH1 KRT20
24 bile duct mucinous adenocarcinoma 10.6 CDX2 KRT7
25 giant cell tumor 10.6 CDX2 KRT20
26 hordeolum 10.6 KRT20 KRT7
27 degenerative myopia 10.6 KRT20 KRT7
28 stromal predominant kidney wilms' tumor 10.6 CDX2 KRT7
29 tubular adenocarcinoma 10.6 CDX2 MUC2
30 cholangitis 10.6 CDX2 MUC2
31 neuroendocrine tumor 10.6 CDX2 KRT20
32 breast secretory carcinoma 10.6 KRT20 KRT7
33 pineal region meningioma 10.6 CDH1 CDX2
34 breast mucinous cystadenocarcinoma 10.5 CDX2 KRT20 MUC2
35 small intestine leiomyoma 10.5 KRT20 TP53
36 intrahepatic bile duct adenoma 10.5 KRT20 TP53
37 diffuse lipomatosis 10.5 CHGA KRT7
38 extrahepatic bile duct adenoma 10.5 KRT20 TP53
39 intracranial sinus thrombosis 10.5 CDX2 MUC2 MUC6
40 morbid obesity 10.5 MUC1 MUC6
41 intrahepatic cholangiocarcinoma 10.5 CDX2 KRT20 KRT7
42 myotonia congenita 10.5 CDX2 KRT20 KRT7
43 lipid-cell variant infiltrating bladder urothelial carcinoma 10.5 KRT7 TP53
44 ovarian melanoma 10.5 CDX2 KRT20 KRT7
45 ampulla of vater squamous cell carcinoma 10.5 CDH1 KRT20 MUC6
46 renal pelvis urothelial papilloma 10.4 CDH1 TP53
47 childhood teratoma of the ovary 10.4 CDH1 CDX2 KRT20
48 paralytic ileus 10.4 CDX2 KRT20 KRT7
49 breast pericanalicular fibroadenoma 10.4 KRT20 TP53
50 vulvar angiokeratoma 10.4 KRT7 MUC1

Graphical network of the top 20 diseases related to Signet Ring Cell Adenocarcinoma:



Diseases related to Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Signet Ring Cell Adenocarcinoma

MGI Mouse Phenotypes related to Signet Ring Cell Adenocarcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 TP53 TUB CDH1 CDX2 CTNNB1 KRT7
2 endocrine/exocrine gland MP:0005379 9.76 TP53 TUB CDH1 CDX2 CHGA CTNNB1
3 neoplasm MP:0002006 9.43 TP53 CDH1 CDX2 CTNNB1 MUC2 SRC
4 pigmentation MP:0001186 8.92 TP53 TUB CTNNB1 SRC

Drugs & Therapeutics for Signet Ring Cell Adenocarcinoma

Drugs for Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
2
Pancrelipase Approved Phase 3 53608-75-6
3
Fluorouracil Approved Phase 3 51-21-8 3385
4
Bevacizumab Approved, Investigational Phase 3 216974-75-3
5
Levoleucovorin Approved Phase 3 68538-85-2
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
8 pancreatin Phase 3
9 Pharmaceutical Solutions Phase 3
10 Antibodies Phase 3,Phase 2,Phase 1
11 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
12 Immunoglobulins Phase 3,Phase 2,Phase 1
13 Angiogenesis Inhibitors Phase 3
14 Angiogenesis Modulating Agents Phase 3
15 Antidotes Phase 3
16 Antimetabolites Phase 3
17 Antimetabolites, Antineoplastic Phase 3
18 Bone Density Conservation Agents Phase 3
19 Calcium, Dietary Phase 3
20 Endothelial Growth Factors Phase 3
21 Hematinics Phase 3
22 Immunosuppressive Agents Phase 3
23 Micronutrients Phase 3
24 Mitogens Phase 3
25 Protective Agents Phase 3
26 Trace Elements Phase 3
27 Vitamin B Complex Phase 3
28 Vitamins Phase 3
29 Cola Nutraceutical Phase 3,Phase 1,Phase 2
30 Folate Nutraceutical Phase 3
31 Vitamin B9 Nutraceutical Phase 3
32
Cisplatin Approved Phase 1, Phase 2 15663-27-1 84093 441203 2767
33
nivolumab Approved Phase 2 946414-94-4
34 Alkylating Agents Phase 1, Phase 2
35 Anti-Bacterial Agents Phase 1, Phase 2
36 Antibiotics, Antitubercular Phase 1, Phase 2
37 Mitomycins Phase 1, Phase 2
38 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
39
Cetuximab Approved Phase 1 205923-56-4 56842117 2333
40
Epirubicin Approved 56420-45-2 41867

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 D2 Resection and HIPEC (Hyperthermic Intraperitoneal Chemoperfusion) in Locally Advanced Gastric Carcinoma Recruiting NCT01882933 Phase 3 HIPEC (Hyperthermic Intraperitoneal Chemoperfusion) with oxaliplatin
2 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Active, not recruiting NCT00217737 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
3 Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients Completed NCT02575859 Phase 1, Phase 2 adjuvant HIPEC
4 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
5 Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Active, not recruiting NCT01802320 Phase 2 Akt Inhibitor MK2206
6 Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer Terminated NCT01198535 Phase 1 Gamma-Secretase Inhibitor RO4929097
7 Prognosis of Signet Ring Cells in Upper Digestive Neoplasms Completed NCT01249859
8 Signet Ring Cell Carcinoma in Esophageal Adenocarcinoma Completed NCT01824966
9 NBI for Identifying Resection Margin Status in Gastric Cancer Completed NCT02926716
10 Evaluation of Surgery Versus Primary Chemotherapy in Resectable Signet Ring Cell Gastric Adenocarcinoma Recruiting NCT01717924

Search NIH Clinical Center for Signet Ring Cell Adenocarcinoma

Cochrane evidence based reviews: carcinoma, signet ring cell

Genetic Tests for Signet Ring Cell Adenocarcinoma

Anatomical Context for Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Cell Adenocarcinoma:

39
Colon, Bone, Prostate, Skin, Endothelial, Bone Marrow, Cervix

Publications for Signet Ring Cell Adenocarcinoma

Articles related to Signet Ring Cell Adenocarcinoma:

(show top 50) (show all 72)
id Title Authors Year
1
Peritoneal carcinomatosis from signet-ring cell adenocarcinoma of the appendix. ( 28322773 )
2017
2
Leptomeningeal carcinomatosis in a young patient with obstructive colorectal signet- ring cell adenocarcinoma. ( 28530107 )
2017
3
Early-Onset Signet-Ring Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature. ( 28326211 )
2017
4
Pulmonary Signet-Ring Cell Adenocarcinoma Metastatic to the Skin. ( 27898475 )
2016
5
A rare case of metastatic germ cell tumor to stomach and duodenum masquerading as signet ring cell adenocarcinoma. ( 27668229 )
2016
6
A Rare Case of an Adult with Untreated Bladder Exstrophy Presenting with Signet-Ring Cell Adenocarcinoma of Urinary Bladder. ( 28050437 )
2016
7
Primary signet ring cell adenocarcinoma of the uterine cervix - A rare neoplasm that raises the question of metastasis to the cervix. ( 27331127 )
2016
8
Primary signet-ring cell adenocarcinoma of the head and neck: a case study and brief review. ( 27185232 )
2016
9
Signet Ring Cell Adenocarcinoma and Bilateral Leptomeningeal Involvement of Optic Nerve Sheaths. ( 25839780 )
2015
10
Colonic-type appendiceal adenocarcinoma: an intermediate prognosis between mucinous and signet ring cell adenocarcinoma. ( 26735622 )
2015
11
A case with primary signet ring cell adenocarcinoma of the prostate and review of the literature. ( 25017602 )
2014
12
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
13
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
14
The impact of preoperative radiochemotherapy on survival in advanced esophagogastric junction signet ring cell adenocarcinoma. ( 24200394 )
2014
15
Primary Signet Ring Cell Adenocarcinoma of the Urinary Bladder: A Report of 2 Cases. ( 26955554 )
2014
16
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ( 22429319 )
2013
17
Primary signet-ring cell adenocarcinoma of the uterine cervix: case report and review of the literature. ( 24020147 )
2013
18
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
19
Primary pure signet-ring cell adenocarcinoma of the urinary bladder: a report of three cases with an immunohistochemical study. ( 22120516 )
2012
20
Signet ring cell adenocarcinoma of the ampulla of Vater: a rare patho. ( 23130863 )
2012
21
Metastatic signet ring cell adenocarcinoma of the bladder: responsive to treatment? ( 22396377 )
2012
22
Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report. ( 21719143 )
2011
23
Primary pure signet ring cell adenocarcinoma of non-Barrett's esophagus. ( 22275019 )
2011
24
An unusual case of signet ring cell adenocarcinoma of the prostate. ( 21797141 )
2011
25
Secondary signet-ring cell adenocarcinoma of urinary bladder from a gastric primary. ( 21747602 )
2011
26
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
27
Interval signet-ring cell adenocarcinoma of the colon: missed or de novo? ( 21540911 )
2011
28
A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation. ( 22022068 )
2011
29
Morphometric distinction of signet-ring cell adenocarcinoma cells from foamy macrophages in gastric endoscopic biopsies. ( 22102070 )
2011
30
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
31
Primary signet-ring cell adenocarcinoma of the endometrium: case report and review of the literature. ( 20407328 )
2010
32
Tonsillar metastasis of signet-ring cell adenocarcinoma of the colon. ( 20737376 )
2010
33
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
34
Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009. ( 20378938 )
2010
35
Signet-ring-cell adenocarcinoma of the myocardium presenting as persistent pleural effusions. ( 19772035 )
2009
36
Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder. ( 18789486 )
2009
37
Signet ring cell adenocarcinoma of the oropharynx: presentation of a rare case and review of the literature. ( 19446973 )
2009
38
Metastatic signet ring cell adenocarcinoma of bone marrow with bilateral ovarian masses: a case report. ( 19019234 )
2008
39
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
40
Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profile. ( 17550327 )
2007
41
Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report. ( 17913950 )
2007
42
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )
2006
43
Signet-ring-cell adenocarcinoma arising from a hyperplastic polyp in the stomach. ( 15758936 )
2005
44
FDG PET imaging of signet-ring cell adenocarcinoma of the stomach. ( 15647683 )
2005
45
Primary signet ring cell adenocarcinoma of the bladder. ( 15951737 )
2005
46
Signet ring cell adenocarcinoma of the urachus. ( 15379946 )
2004
47
Epididymal metastasis from gastric signet ring cell adenocarcinoma. ( 12010596 )
2002
48
Primary signet ring cell adenocarcinomas of the lung: a clinicopathological study of 15 cases. ( 11683941 )
2001
49
Gastric signet ring cell adenocarcinoma metastatic to the iris. ( 11239875 )
2001
50
Severe prognosis of signet-ring cell adenocarcinoma occurring in Meckel's diverticulum. ( 11300339 )
2001

Variations for Signet Ring Cell Adenocarcinoma

Expression for Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Cell Adenocarcinoma.

Pathways for Signet Ring Cell Adenocarcinoma

Pathways related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 CDH1 CTNNB1 SRC TP53
2 12.28 CDH1 KRT20 KRT7 MUC1
3
Show member pathways
12.15 MUC1 MUC2 MUC6 SRC
4
Show member pathways
12.08 CDH1 CTNNB1 SRC
5 11.97 CDH1 CTNNB1 TP53
6
Show member pathways
11.94 MUC1 MUC2 MUC6
7 11.9 CTNNB1 SRC TP53
8 11.84 CDH1 CTNNB1 SRC TP53
9 11.83 CDH1 CTNNB1 SRC
10 11.8 CTNNB1 SRC TP53
11 11.77 CTNNB1 SRC TP53
12 11.75 CDH1 CTNNB1 MUC1
13
Show member pathways
11.74 MUC1 MUC2 MUC6
14
Show member pathways
11.62 CDH1 CTNNB1 SRC
15
Show member pathways
11.52 CDH1 CTNNB1 MUC1 SRC TP53
16 11.51 CDH1 CTNNB1 SRC
17 11.44 CDH1 SRC TP53
18 11.4 CDH1 CTNNB1 SRC
19 11.15 CDH1 CTNNB1 SRC
20 11.03 CDH1 CTNNB1 SRC
21 10.85 CDH1 SRC
22 10.85 CDH1 CTNNB1 SRC
23 10.62 CDH1 CTNNB1
24 10.53 CDH1 CTNNB1 SRC

GO Terms for Signet Ring Cell Adenocarcinoma

Cellular components related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.33 MUC1 MUC2 MUC6
2 apical junction complex GO:0043296 9.26 CDH1 CTNNB1
3 catenin complex GO:0016342 8.96 CDH1 CTNNB1
4 flotillin complex GO:0016600 8.62 CDH1 CTNNB1

Biological processes related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 CDH1 CDX2 CTNNB1 SRC TP53
2 single organismal cell-cell adhesion GO:0016337 9.63 CDH1 CTNNB1 SRC
3 bone resorption GO:0045453 9.51 CTNNB1 SRC
4 O-glycan processing GO:0016266 9.5 MUC1 MUC2 MUC6
5 anterior/posterior axis specification GO:0009948 9.49 CDX2 CTNNB1
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.48 MUC1 TP53
7 maintenance of gastrointestinal epithelium GO:0030277 9.43 MUC2 MUC6
8 negative regulation of telomerase activity GO:0051974 9.4 SRC TP53
9 adherens junction organization GO:0034332 9.33 CDH1 CTNNB1 SRC
10 cellular response to indole-3-methanol GO:0071681 9.26 CDH1 CTNNB1
11 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC1 MUC2 MUC6 SRC
12 entry of bacterium into host cell GO:0035635 8.8 CDH1 CTNNB1 SRC

Sources for Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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