MCID: SGN002
MIFTS: 47

Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Signet Ring Cell Adenocarcinoma:

Name: Signet Ring Cell Adenocarcinoma 12 14
Carcinoma, Signet Ring Cell 41 69
Signet Ring Cell Carcinoma 12
Carcinoma Signet Ring Cell 51
Signet Ring Carcinoma Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3493
MeSH 41 D018279
NCIt 46 C3774
UMLS 69 C0206696

Summaries for Signet Ring Cell Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which have signet ring appearance.

MalaCards based summary : Signet Ring Cell Adenocarcinoma, also known as carcinoma, signet ring cell, is related to gastric signet ring cell adenocarcinoma and linitis plastica. An important gene associated with Signet Ring Cell Adenocarcinoma is MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Development HGF signaling pathway and Gastric cancer. The drugs Bevacizumab and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and prostate, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Signet Ring Cell Adenocarcinoma

Diseases related to Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 gastric signet ring cell adenocarcinoma 34.2 CDH1 CDX2
2 linitis plastica 30.6 CDH1 KRT20 KRT7
3 adenocarcinoma 30.2 CDH1 CTNNB1 MUC1 TP53
4 ethmoid sinusitis 30.1 MUC1 MUC2 MUC6
5 colon adenocarcinoma 29.7 CDH1 CTNNB1 KRT20
6 bladder signet ring cell adenocarcinoma 12.5
7 bile duct signet ring cell carcinoma 12.4
8 gallbladder signet ring cell adenocarcinoma 12.3
9 breast signet ring cell adenocarcinoma 12.3
10 prostate signet ring cell adenocarcinoma 12.3
11 pancreatic signet ring cell adenocarcinoma 12.2
12 ampullary signet ring cell adenocarcinoma 12.2
13 diffuse gastric cancer 12.0
14 rectum signet ring adenocarcinoma 11.6
15 gastric cancer, hereditary diffuse 11.3
16 cystic basal cell carcinoma 10.5 KRT20 KRT7
17 seminal vesicle adenocarcinoma 10.5 KRT20 KRT7
18 transverse colon cancer 10.5 KRT20 KRT7
19 eyelid neoplasm 10.5 KRT20 KRT7
20 malignant syringoma 10.5 KRT20 KRT7
21 krukenberg carcinoma 10.5 KRT20 KRT7
22 mucinous intrahepatic cholangiocarcinoma 10.5 CDX2 MUC2
23 vulval paget's disease 10.5 KRT20 KRT7
24 mucinous adenofibroma 10.5 CDX2 KRT7
25 intratubular embryonal carcinoma 10.5 KRT20 KRT7
26 adenoma of the pancreas 10.4 CHGA KRT20
27 anal canal adenocarcinoma 10.4 CDX2 KRT7
28 morpheaform basal cell carcinoma 10.4 CDH1 KRT20
29 endocervical carcinoma 10.4 KRT7 MUC6
30 diversion colitis 10.4 CDH1 MUC2
31 meibomian cyst 10.4 KRT20 KRT7
32 bladder lymphoma 10.4 KRT20 KRT7
33 chronic cholangitis 10.4 CDX2 MUC2
34 renal pelvis carcinoma 10.4 KRT20 KRT7
35 epithelial predominant wilms' tumor 10.4 CDX2 KRT7
36 medulloepithelioma 10.4 KRT20 KRT7
37 bronchiolo-alveolar adenocarcinoma 10.4 CDX2 KRT7
38 pancreatic serous cystadenoma 10.4 CHGA KRT7
39 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 CDX2 MUC2
40 bladder papillary transitional cell neoplasm 10.3 KRT20 TP53
41 urinary tract papillary transitional cell benign neoplasm 10.3 KRT20 TP53
42 malignant spiradenoma 10.3 KRT7 TP53
43 middle ear adenoma 10.3 KRT7 MUC1
44 vulvar intraepithelial neoplasia 10.3 KRT7 TP53
45 endosalpingiosis 10.3 KRT7 MUC1
46 parachordoma 10.3 KRT7 MUC1
47 bladder adenocarcinoma 10.3 CDX2 KRT20 KRT7
48 thymus adenocarcinoma 10.3 CDX2 KRT20 KRT7
49 vulva adenocarcinoma 10.3 CDX2 KRT20 KRT7
50 jejunal adenocarcinoma 10.3 CDX2 KRT20 KRT7

Graphical network of the top 20 diseases related to Signet Ring Cell Adenocarcinoma:



Diseases related to Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Signet Ring Cell Adenocarcinoma

MGI Mouse Phenotypes related to Signet Ring Cell Adenocarcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 CDH1 CDX2 CTNNB1 KRT7 MUC2 SRC
2 endocrine/exocrine gland MP:0005379 9.76 CDH1 CDX2 CHGA CTNNB1 MUC2 SRC
3 neoplasm MP:0002006 9.43 CDH1 CDX2 CTNNB1 MUC2 SRC TP53
4 pigmentation MP:0001186 8.92 CTNNB1 SRC TP53 TUB

Drugs & Therapeutics for Signet Ring Cell Adenocarcinoma

Drugs for Signet Ring Cell Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2
Fluorouracil Approved Phase 3 51-21-8 3385
3
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
4
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
5
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
8 Antibodies Phase 3,Phase 2,Phase 1
9 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
10 Immunoglobulins Phase 3,Phase 2,Phase 1
11 Angiogenesis Inhibitors Phase 3
12 Angiogenesis Modulating Agents Phase 3
13 Antidotes Phase 3
14 Antimetabolites Phase 3
15 Antimetabolites, Antineoplastic Phase 3
16 Bone Density Conservation Agents Phase 3
17 Calcium, Dietary Phase 3
18 Endothelial Growth Factors Phase 3
19 Hematinics Phase 3
20 Immunosuppressive Agents Phase 3
21 Micronutrients Phase 3
22 Mitogens Phase 3
23 Protective Agents Phase 3
24 Trace Elements Phase 3
25 Vitamin B Complex Phase 3
26 Vitamins Phase 3
27 Cola Nutraceutical Phase 3,Phase 1,Phase 2
28 Folate Nutraceutical Phase 3
29 Vitamin B9 Nutraceutical Phase 3
30
Cisplatin Approved Phase 1, Phase 2 15663-27-1 2767 441203 84093
31
nivolumab Approved Phase 2 946414-94-4
32 Alkylating Agents Phase 1, Phase 2
33 Anti-Bacterial Agents Phase 1, Phase 2
34 Antibiotics, Antitubercular Phase 1, Phase 2
35 Mitomycins Phase 1, Phase 2
36 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
37
Cetuximab Approved Phase 1 205923-56-4 56842117 2333

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Active, not recruiting NCT00217737 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
2 XELOX Plus Apatinib vs XELOX as Post-operative Chemotherapy in Locally Advanced Gastric Signet Ring Carcinoma Not yet recruiting NCT03355612 Phase 3 Apatinib;XELOX
3 Adjuvant HIPEC to Prevent Colorectal Peritoneal Metastases in High-risk Patients Completed NCT02575859 Phase 1, Phase 2 adjuvant HIPEC
4 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
5 Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Active, not recruiting NCT01802320 Phase 2 Akt Inhibitor MK2206
6 Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer Terminated NCT01198535 Phase 1 Gamma-Secretase Inhibitor RO4929097
7 Prognosis of Signet Ring Cells in Upper Digestive Neoplasms Completed NCT01249859
8 Signet Ring Cell Carcinoma in Esophageal Adenocarcinoma Completed NCT01824966
9 NBI for Identifying Resection Margin Status in Gastric Cancer Completed NCT02926716

Search NIH Clinical Center for Signet Ring Cell Adenocarcinoma

Cochrane evidence based reviews: carcinoma, signet ring cell

Genetic Tests for Signet Ring Cell Adenocarcinoma

Anatomical Context for Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Signet Ring Cell Adenocarcinoma:

38
Colon, Bone, Prostate, Skin, Endothelial, Bone Marrow, Cervix

Publications for Signet Ring Cell Adenocarcinoma

Articles related to Signet Ring Cell Adenocarcinoma:

(show top 50) (show all 75)
# Title Authors Year
1
Treatment of a pediatric patient with MET-amplified signet ring cell adenocarcinoma of the stomach with crizotinib. ( 29380521 )
2018
2
Early-Onset Signet-Ring Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature. ( 28326211 )
2017
3
Leptomeningeal carcinomatosis in a young patient with obstructive colorectal signet- ring cell adenocarcinoma. ( 28530107 )
2017
4
Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature. ( 29375924 )
2017
5
Peritoneal carcinomatosis from signet-ring cell adenocarcinoma of the appendix. ( 28322773 )
2017
6
The relevance and implications of signet-ring cell adenocarcinoma of the oesophagus. ( 29212656 )
2017
7
Primary signet-ring cell adenocarcinoma of the head and neck: a case study and brief review. ( 27185232 )
2016
8
Primary signet ring cell adenocarcinoma of the uterine cervix - A rare neoplasm that raises the question of metastasis to the cervix. ( 27331127 )
2016
9
A Rare Case of an Adult with Untreated Bladder Exstrophy Presenting with Signet-Ring Cell Adenocarcinoma of Urinary Bladder. ( 28050437 )
2016
10
Pulmonary Signet-Ring Cell Adenocarcinoma Metastatic to the Skin. ( 27898475 )
2016
11
A rare case of metastatic germ cell tumor to stomach and duodenum masquerading as signet ring cell adenocarcinoma. ( 27668229 )
2016
12
Colonic-type appendiceal adenocarcinoma: an intermediate prognosis between mucinous and signet ring cell adenocarcinoma. ( 26735622 )
2015
13
Signet Ring Cell Adenocarcinoma and Bilateral Leptomeningeal Involvement of Optic Nerve Sheaths. ( 25839780 )
2015
14
Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma. ( 25436133 )
2014
15
A case with primary signet ring cell adenocarcinoma of the prostate and review of the literature. ( 25017602 )
2014
16
Primary Signet Ring Cell Adenocarcinoma of the Urinary Bladder: A Report of 2 Cases. ( 26955554 )
2014
17
Biopsy-triggered gastric signet ring cell adenocarcinoma proliferation. ( 25524189 )
2014
18
The impact of preoperative radiochemotherapy on survival in advanced esophagogastric junction signet ring cell adenocarcinoma. ( 24200394 )
2014
19
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ( 22429319 )
2013
20
Primary signet-ring cell adenocarcinoma of the uterine cervix: case report and review of the literature. ( 24020147 )
2013
21
Risk factors of peritoneal recurrence in eso-gastric signet ring cell adenocarcinoma: results of a multicentre retrospective study. ( 23313257 )
2013
22
Primary pure signet-ring cell adenocarcinoma of the urinary bladder: a report of three cases with an immunohistochemical study. ( 22120516 )
2012
23
Signet ring cell adenocarcinoma of the ampulla of Vater: a rare patho. ( 23130863 )
2012
24
Metastatic signet ring cell adenocarcinoma of the bladder: responsive to treatment? ( 22396377 )
2012
25
Secondary signet-ring cell adenocarcinoma of urinary bladder from a gastric primary. ( 21747602 )
2011
26
A case of signet ring cell adenocarcinoma of the bladder with spontaneous urinary extravasation. ( 22022068 )
2011
27
Interval signet-ring cell adenocarcinoma of the colon: missed or de novo? ( 21540911 )
2011
28
Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report. ( 21719143 )
2011
29
The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. ( 22005144 )
2011
30
Morphometric distinction of signet-ring cell adenocarcinoma cells from foamy macrophages in gastric endoscopic biopsies. ( 22102070 )
2011
31
Primary pure signet ring cell adenocarcinoma of non-Barrett's esophagus. ( 22275019 )
2011
32
An unusual case of signet ring cell adenocarcinoma of the prostate. ( 21797141 )
2011
33
Tonsillar metastasis of signet-ring cell adenocarcinoma of the colon. ( 20737376 )
2010
34
Signet-ring cell adenocarcinoma of the bladder: case series between 1990-2009. ( 20378938 )
2010
35
Sister Mary Joseph's nodule as the sole presenting sign of gastric signet ring cell adenocarcinoma. ( 20739130 )
2010
36
Unfound gastric signet ring-cell adenocarcinoma after gastric biopsy. ( 20425670 )
2010
37
Primary signet-ring cell adenocarcinoma of the endometrium: case report and review of the literature. ( 20407328 )
2010
38
Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder. ( 18789486 )
2009
39
Signet-ring-cell adenocarcinoma of the myocardium presenting as persistent pleural effusions. ( 19772035 )
2009
40
Signet ring cell adenocarcinoma of the oropharynx: presentation of a rare case and review of the literature. ( 19446973 )
2009
41
Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax. ( 18263634 )
2008
42
Metastatic signet ring cell adenocarcinoma of bone marrow with bilateral ovarian masses: a case report. ( 19019234 )
2008
43
Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report. ( 17913950 )
2007
44
Signet-ring cell adenocarcinoma of sinonasal tract: an immunohistochemical study of the mucins profile. ( 17550327 )
2007
45
Gastric signet-ring cell adenocarcinoma metastatic to the gingiva: a case report. ( 16831674 )
2006
46
FDG PET imaging of signet-ring cell adenocarcinoma of the stomach. ( 15647683 )
2005
47
Signet-ring-cell adenocarcinoma arising from a hyperplastic polyp in the stomach. ( 15758936 )
2005
48
Primary signet ring cell adenocarcinoma of the bladder. ( 15951737 )
2005
49
Signet ring cell adenocarcinoma of the urachus. ( 15379946 )
2004
50
Epididymal metastasis from gastric signet ring cell adenocarcinoma. ( 12010596 )
2002

Variations for Signet Ring Cell Adenocarcinoma

Expression for Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Signet Ring Cell Adenocarcinoma.

Pathways for Signet Ring Cell Adenocarcinoma

Pathways related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 CDH1 CTNNB1 SRC TP53
2
Show member pathways
12.43 CDH1 CDX2 CTNNB1 MUC2 TP53
3 12.3 CDH1 KRT20 KRT7 MUC1
4
Show member pathways
12.17 MUC1 MUC2 MUC6 SRC
5
Show member pathways
12.1 CDH1 CTNNB1 SRC
6 11.98 CDH1 CTNNB1 TP53
7
Show member pathways
11.95 MUC1 MUC2 MUC6
8 11.91 CTNNB1 SRC TP53
9 11.84 CDH1 CTNNB1 SRC
10 11.84 CDH1 CTNNB1 SRC TP53
11 11.83 CDH1 CTNNB1 MUC1
12 11.8 CTNNB1 SRC TP53
13 11.77 CTNNB1 SRC TP53
14
Show member pathways
11.75 MUC1 MUC2 MUC6
15
Show member pathways
11.63 CDH1 CTNNB1 SRC
16 11.53 CDH1 CTNNB1 SRC
17
Show member pathways
11.51 CDH1 CTNNB1 MUC1 SRC TP53
18 11.47 CDH1 SRC TP53
19 11.44 CDH1 CTNNB1 SRC
20 11.16 CDH1 CTNNB1 SRC
21 11.03 CDH1 CTNNB1 SRC
22 10.86 CDH1 SRC
23 10.85 CDH1 CTNNB1 SRC
24 10.64 CDH1 CTNNB1
25 10.53 CDH1 CTNNB1 SRC

GO Terms for Signet Ring Cell Adenocarcinoma

Cellular components related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.33 MUC1 MUC2 MUC6
2 apical junction complex GO:0043296 9.26 CDH1 CTNNB1
3 catenin complex GO:0016342 8.96 CDH1 CTNNB1
4 flotillin complex GO:0016600 8.62 CDH1 CTNNB1

Biological processes related to Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 CDH1 CDX2 CTNNB1 SRC TP53
2 response to drug GO:0042493 9.73 CDH1 CTNNB1 SRC TP53
3 cell-cell adhesion GO:0098609 9.65 CDH1 CTNNB1 SRC
4 bone resorption GO:0045453 9.52 CTNNB1 SRC
5 anterior/posterior axis specification GO:0009948 9.51 CDX2 CTNNB1
6 O-glycan processing GO:0016266 9.5 MUC1 MUC2 MUC6
7 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.49 MUC1 TP53
8 maintenance of gastrointestinal epithelium GO:0030277 9.46 MUC2 MUC6
9 negative regulation of telomerase activity GO:0051974 9.4 SRC TP53
10 adherens junction organization GO:0034332 9.33 CDH1 CTNNB1 SRC
11 cellular response to indole-3-methanol GO:0071681 9.26 CDH1 CTNNB1
12 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC1 MUC2 MUC6 SRC
13 entry of bacterium into host cell GO:0035635 8.8 CDH1 CTNNB1 SRC

Sources for Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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