MCID: SLC006
MIFTS: 52

Silicosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

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Aliases & Descriptions for Silicosis:

Name: Silicosis 32 10 45 47 12 36 65
Silicotuberculosis 10 65
Chronic Silicosis 45 65
Acute Silicosis 45 65
Pneumoconiosis Due to Silicates 10
 
Silicotic Fibrosis of Lung 10
Experimental Silicosis 45
Silica Pneumoconiosis 10
Accelerated Silicosis 45

Classifications:



External Ids:

Disease Ontology10 DOID:10325
ICD1027 J62, J62.8
ICD9CM29 502
MeSH36 D012829
NCIt42 C3369
UMLS65 C0037116, C0037118, C0340190 C0340192, more

Summaries for Silicosis

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NIH Rare Diseases:45 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. a cough, weight loss, and fatigue may also be present. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 12/17/2015

MalaCards based summary: Silicosis, also known as silicotuberculosis, is related to lateral sclerosis and burns. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Signal transduction_JNK pathway. Affiliated tissues include lung, bone and heart, and related mouse phenotypes are liver/biliary system and endocrine/exocrine gland.

Disease Ontology:10 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:68 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 558)
idRelated DiseaseScoreTop Affiliating Genes
1lateral sclerosis30.6IL10, IL1B, TNF
2burns30.4FAS, TGFB1
3skin disease30.3IL1A, TNF
4hepatitis30.0CXCL8, FAS, IL18, TNF
5food allergy30.0IL10, IL1B, TNF
6optic neuritis30.0CXCL8, IL1A, IL1B
7mouth disease29.9CXCL8, IL1B, IL1RN
8hyperglycemia29.9ACE, IL1B, TNF
9obstructive sleep apnea29.8ACE, CXCL8, TNF
10fibrosing mediastinitis29.8ACE, TGFB1
11lymphedema29.7FAS, IL1B, TGFB1, TNF
12xanthogranulomatous pyelonephritis29.7ACE, CXCL8, IL10
13neurogenic bladder29.6IL10, IL1B, TGFB1, TNF
14systemic lupus erythematosus29.3FAS, FASLG, IL10, IL18, TNF
15heart disease29.3ACE, CXCL8, FASLG, IL1B, IL1RN, SCGB1A1
16obesity28.6CXCL8, IL10, IL18, IL1B, TGFB1, TNF
17rheumatoid arthritis28.4CXCL8, IL10, IL18, IL1A, IL1B, IL1RN
18asthma27.1ACE, CXCL8, FAS, IL10, IL18, IL1A
19pneumoconiosis due to talc10.9
20polycythemia10.5IL1B, TNF
21punctate palmoplantar keratoderma type 210.5IL10, TNF
22stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.5IL1B, TNF
23primary progressive freezing gait10.4IL10, TNF
24peyronie's disease10.4IL1B, TNF
25developmental and speech delay due to sox5 deficiency10.4FAS, FASLG, TNF
26anatomical narrow angle borderline glaucoma10.4IL1A, IL1B
27malignant sertoli-leydig cell tumor of ovary10.4CXCL8, TNF
28kearns-sayre syndrome10.4IL10, TNF
29endometritis10.4FAS, TNF
30multifocal lymphangioendotheliomatosis with thrombocytopenia10.4IL10, TNF
31gastric cancer risk after h. pylori infection10.4IL1B, IL1RN
32optic nerve disease10.4FAS, FASLG, TNF
33waardenburg syndrome type 410.3IL1B, IL1RN, TNF
34best1 retinopathy10.3TGFB1, TNF
35corneal abscess10.3CXCL8, IL1B
36refractory plasma cell neoplasm10.3IL1B, IL1RN, TNF
37pustulosis of palm and sole10.3ACE, TNF
38alternating exotropia10.3IL10, TNF
39posterior amorphous corneal dystrophy10.3FAS, IL1A
40anthracosis10.3
41interstitial lung disease10.3
42skeletal tuberculosis10.3FAS, FASLG, IL1B
43miliary tuberculosis10.3IL1A, IL1RN, TNF
44secretory diarrhea10.3IL1B, IL1RN, TNF
45lujo hemorrhagic fever10.3IL1A, IL1B, TNF
46dancing eyes-dancing feet syndrome10.3FAS, IL10, TNF
47pustulosis palmaris et plantaris10.3CXCL8, IL1RN, TNF
48cerebral sarcoidosis10.3ACE, TNF
49carotid artery disease10.3IL1B, IL1RN, TNF
50achalasia10.3IL10, TNF

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Symptoms for Silicosis

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Drugs & Therapeutics for Silicosis

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Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IsoniazidapprovedPhase 314254-85-33767
Synonyms:
37271-10-6
4-pyridinecarbohydrazide
41466-07-3
5015 R.P
5015 R.P.
5015 RP
54-85-3
62229-51-0
7640-37-1
AB00052025
AC1L1GNZ
AC1Q54UP
AC1Q54UQ
AI3-23936
AKOS000119062
AZT + Isoniazid
Abdizide
Andrazide
Anidrasona
Antimicina
Antituberkulosum
Armacide
Armazid
Armazide
Atcotibine
Azuren
BB_SC-6246
BIDD:GT0140
BP 5015
BPBio1_000025
BPBio1_001322
BSPBio_000021
BSPBio_002204
Bacillin
Biomol-NT_000288
C07054
C6H7N3O
CAS-54-85-3
CCRIS 351
CHEBI:6030
CHEMBL64
CID3767
CPD000059082
Cedin
Cedin (Aerosol)
Cemidon
Chemiazid
Chemidon
Continazine
Cortinazine
Cotinazin
Cotinizin
D00346
D007538
DB00951
Defonin
Dibutin
Diforin
Dinacrin
Ditubin
DivK1c_000070
Dow-Isoniazid
EINECS 200-214-6
Ebidene
Eralon
Ertuban
Eutizon
Evalon
FRS-3
FSR 3
FSR-3
Fetefu
Fimalene
GINK
HIA
HMS1568B03
HMS1920H09
HMS2089I16
HMS2091N19
HMS500D12
HSDB 1647
Hid rasonil
Hidranizil
Hidrasonil
Hidrulta
Hidrun
Hycozid
Hydra
Hydrazid
Hydrazide
Hyozid
Hyzyd
I.A.I
I.A.I.
I0138
I14-9731
I3377_FLUKA
I3377_SIGMA
IDI1_000070
INH
INHd20
Ido-tebin
Idrazil
In-73
Inah
Inh-Burgthal
Inizid
Iscotin
Isidrina
Ismazide
Isobicina
Isocid
Isocidene
Isocotin
Isohydrazide
Isokin
Isolyn
Isonerit
Isonex
Isoniacid
Isoniazid
Isoniazid & EEP
Isoniazid & Propolis
Isoniazid SA
Isoniazida
Isoniazide
Isoniazidum
Isonicazide
Isonicid
Isonico
Isonicotan
Isonicotil
Isonicotinhydrazid
Isonicotinic acid hydrazide
Isonicotinic hydrazide
Isonicotinohydrazide
Isonicotinoyl hydrazide
Isonicotinoylhydrazide
Isonicotinsaeurehydrazid
Isonicotinyl hydrazide
Isonicotinyl hydrazine
Isonicotinylhydrazine
Isonide
Isonidrin
Isonikazid
Isonilex
Isonin
Isonindon
Isonirit
Isoniton
Isonizida
Isonizide
Isopyrin
 
Isotamine
Isotebe
Isotebezid
Isotinyl
Isozid
Isozide
Isozyd
KBio1_000070
KBio2_001333
KBio2_003901
KBio2_006469
KBio3_001424
KBioGR_000423
KBioSS_001333
L 1945
LANIZID
LS-205
Laniazid
Laniazid (TN)
Laniozid
MLS000069444
MLS001055327
MolPort-000-141-557
Mybasan
NCGC00016244-01
NCGC00016244-02
NCGC00022648-03
NCGC00022648-04
NCGC00022648-05
NCGC00022648-06
NINDS_000070
NSC 9659
NSC9659
Neo-Tizide
Neoteben
Neoxin
Neumandin
Nevin
Niadrin
Nicazide
Nicetal
Nicizina
Niconyl
Nicotibina
Nicotibine
Nicotisan
Nicozide
Nidaton
Nidrazid
Nikozid
Niplen
Nitadon
Niteban
Nitebannsc 9659
Nydrazid
Nyscozid
Oprea1_396155
Pelazid
Percin
Phthisen
Preparation 6424
Prestwick0_000161
Prestwick1_000161
Prestwick2_000161
Prestwick3_000161
Prestwick_578
Pycazide
Pyreazid
Pyricidin
Pyridicin
Pyridine-4-carboxylic acid hydrazide
Pyrizidin
RP 5015
RP-5015
RU-EF-Tb
RY-EF-Tb
Raumanon
Razide
Retozide
Rifamate
Rimicid
Rimifon
Rimiphone
Rimitsid
Robiselin
Robisellin
Roxifen
S1937_Selleck
SAM002554904
SMR000059082
SPBio_000094
SPBio_001942
SPECTRUM1500355
STK086288
Sanohidrazina
Sauterazid
Sauterzid
Spectrum2_000107
Spectrum3_000472
Spectrum4_000022
Spectrum5_000876
Spectrum_000853
Stanozide
TB-Phlogin
TB-Razide
TB-Vis
Tebecid
Tebenic
Tebexin
Tebilon
Tebos
Teebaconin
Tekazin
Tibazide
Tibemid
Tibiazide
Tibinide
Tibison
Tibivis
Tibizide
Tibusan
Tisin
Tisiodrazida
Tizide
Tubazid
Tubazide
Tubeco
Tubecotubercid
Tuberian
Tubicon
Tubilysin
Tubizid
Tubomel
Tyvid
UNII-V83O1VOZ8L
Unicocyde
Unicozyde
Usaf cb-2
Vazadrine
Vederon
WLN: T6NJ DVMZ
ZINC00001590
Zidafimia
Zinadon
Zonazide
bacillen
bp 5 015
isoco tin
isoniazid
isozid e
nchembio884-comp3
nidra zid
rimif on
tebemid
tubercid
2
RifampicinapprovedPhase 330313292-46-15458213, 5381226
Synonyms:
1-b]furan-21-yl acetate
13292-46-1
3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin sv
3-(4-Methylpiperazinyliminomethyl)-rifamycin SV
3-(4-Methylpiperazinyliminomethyl)rifamycin SV
3-([(4-Methyl-1-piperazinyl)imino]methyl)rifamycin SV
3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV
3-[[(4-Methyl-1-piperazinyl)imino]-methyl]rifamycin
46713_FLUKA
46713_RIEDEL
62534-43-4
8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
8-(4-Methylpiperazinyliminomethyl) rifamycin SV
8-[[(4-Methyl-1-piperazinyl)imino[methyl]rifamycin
8-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin sv
8-[[(4-Methylpiperazinyl)imino]methyl]rifamycin sv
83907_FLUKA
83907_SIGMA
8CI)
AZT + Rifampin
Abrifam
Archidyn
Arficin
Arzide
BA-41166E
BIDD:PXR0014
BPBio1_000561
BSPBio_000509
Ba 41166
Ba 41166/E
Benemicin
Benemycin
Bio-0621
C06688
C43H58N4O12
CAS-13292-46-1
CCRIS 551
CHEBI:28077
CHEBI:455936
CHEMBL180
CID5381226
CID5388984
CID5458213
CID5702112
CID6604339
CID6708473
CID6842115
CID6912767
CID6913622
CPD001906767
D00211
DB01045
DRG-0109
Dione 21-acetate
Dipicin
DivK1c_000550
Doloresum
EINECS 236-312-0
Eremfat
Famcin
Fenampicin
HMS1569J11
HMS1920P08
HMS2089F12
HMS2092G09
HMS501L12
HSDB 3181
KBio1_000550
KBio2_000919
KBio2_003487
KBio2_006055
KBio3_003018
KBioGR_001780
KBioSS_000919
L-5103
L-5103 Lepetit
LS-7689
MLS000028552
MLS001148237
MLS001333745
MolPort-000-767-051
MolPort-002-513-586
MolPort-003-666-281
MolPort-006-395-891
NCGC00016699-01
NCGC00017365-01
NCGC00018178-01
NCGC00022678-03
NCGC00022678-04
NCGC00022678-05
NCGC00160500-01
 
NCI60_000309
NINDS_000550
NSC 113926
NSC-113926
NSC113926
Piperine & Rifampicin
Prestwick0_000525
Prestwick1_000525
Prestwick2_000525
Prestwick3_000525
Prestwick_833
R-Cin
R/AMP
R0079
R3501_SIAL
R3501_SIGMA
R5777_SIGMA
R7382_SIGMA
RAMP
RFP
RMP
Ramp
Reserpine & Rifampicin
Rf
Rfamipicin
Rifa
Rifadin
Rifadin (TN)
Rifadin I.V
Rifadin I.V.
Rifadin IV
Rifadin Iv
Rifadin, Rimactane, Rifampicin, Rifampin
Rifadine
Rifagen
Rifaldazin
Rifaldazine
Rifaldin
Rifam
Rifamicin AMP
Rifamor
Rifampicin
Rifampicin & EEP
Rifampicin & Propolis
Rifampicin (JP15/INN)
Rifampicin SV
Rifampicin [INN:BAN:JAN]
Rifampicin sodium
Rifampicina
Rifampicina [INN-Spanish]
Rifampicine
Rifampicine [French]
Rifampicinum
Rifampicinum [INN-Latin]
Rifampin
Rifampin (USP)
Rifampin [USAN]
Rifamsolin
Rifamycin
Rifamycin AMP
Rifamycin Amp
Rifaprodin
Rifcin
Rifinah
Rifobac
Rifoldin
Rifoldine
Riforal
Rimactan
Rimactane
Rimactane (TN)
Rimactazid
Rimactin
Rimactizid
Rimazid
Rimycin
Rofact
S1764_Selleck
SAM002264646
SMR000058322
SMR000653525
SPBio_002430
SPECTRUM1500529
STK080143
Sinerdol
Spectrum3_001837
Spectrum4_001250
Spectrum5_002018
Spectrum_000439
TNP00313
Tubocin
UNII-VJT6J7R4TR
WLN: V1 WQ A&1 E&1 E1UN- AT6N DNTJ D1
nchembio884-comp4
rifampin
3
RifapentineapprovedPhase 32961379-65-56323497
Synonyms:
(2R,16S,17R,18R,19R,20S,21S,22S,23S)-8-{[(4-CYCLOPENTYLPIPERAZIN-1-YL)IMINO]METHYL}-5,6,9,17,19-PENTAHYDROXY-23-METHOXY-2,4,12,16,18,20,22-HEPTAMETHYL-1,11-DIOXO-1,2-DIHYDRO-2,7-(EPOXYPENTADECA[1,11,13]TRIENOIMINO)NAPHTHO[2,1-B]FURAN-21-YL ACETATE
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV
3-(N-(4-Cyclopentyl-1-piperazinyl)formimidoyl)rifamycin
3-[N-(4-Cyclopentyl-1-piperazinyl)formimidoyl]rifamycin
61379-65-5
71950-35-1
Ambap127923-87-9
Antibiotic DL 473IT
BIDD:GT0669
C08059
C47H64N4O12
CHEBI:45304
CHEMBL1660
CID6323497
CID6434610
CID6835847
CID9919168
CPD000466332
CPD001906779
Cyclopentyl rifampin
Cyclopentylrifampicin
D00879
DB01201
DL 473
DL 473-IT
DL-4-73
DL-473
DL473
DRG-0283
 
EINECS 262-743-9
HMS2051D16
KTC 1
LS-143825
M000473
MDL 473
MDL-473
MDL473
MLS000759441
MLS001424209
NCGC00167431-01
Priftin
Priftin (TN)
Priftin (tn)
Priftin, Cyclopentylrifampicin, Rifapentine
R 77-3
R-773
RIFAPENTINE
RPE
RPT
Rifamycin AF/ACPP
Rifapentin
Rifapentina
Rifapentina [Spanish]
Rifapentine (USAN/INN)
Rifapentine [USAN:BAN:INN]
Rifapentinum
Rifapentinum [Latin]
S1760_Selleck
SAM001246620
SAM002589953
SMR000466332
UNII-XJM390A33U
4Nucleic Acid Synthesis InhibitorsPhase 33836
5Anti-Bacterial AgentsPhase 39140
6Hypolipidemic AgentsPhase 32228
7Antibiotics, AntitubercularPhase 35971
8Antitubercular AgentsPhase 31061
9Anti-Infective AgentsPhase 317220
10AntimetabolitesPhase 39454
11MitogensPhase 1, Phase 21386
12Respiratory System Agents3931

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis PreventionRecruitingNCT02430259Phase 3
2Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat SilicosisCompletedNCT01977131Phase 1, Phase 2
3Safety of Stem Cells Intrabronchial Instillation for SilicosisCompletedNCT01239862Phase 1
4A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem CellsRecruitingNCT02668068Phase 1
5Oscillation Mechanics of the Respiratory System in Never-smoking Patients With SilicosisCompletedNCT01725971
6Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
7Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone)Not yet recruitingNCT01338064
8DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone)Not yet recruitingNCT01329003

Search NIH Clinical Center for Silicosis


Cochrane evidence based reviews: silicosis

Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

33
Lung, Bone, Heart, Endothelial, Bone marrow, T cells, Breast

Animal Models for Silicosis or affiliated genes

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MGI Mouse Phenotypes related to Silicosis:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ACE, FAS, FASLG, IL10, TGFB1, TNF
2MP:00053798.2ACE, FAS, FASLG, IL10, SCGB1A1, TGFB1
3MP:00053818.2FAS, FASLG, IL10, IL18, TGFB1, TNF
4MP:00053898.1ACE, FAS, FASLG, IL10, IL1RN, TGFB1
5MP:00053888.1FAS, FASLG, IL10, SCGB1A1, SFTPD, TGFB1
6MP:00053907.7FAS, FASLG, IL10, IL1B, IL1RN, TGFB1
7MP:00020067.6ACE, FAS, FASLG, IL10, IL1A, IL1B
8MP:00107717.3FAS, FASLG, IL10, IL18, IL1A, IL1B
9MP:00053786.8ACE, FAS, IL10, IL18, IL1RN, SCGB1A1
10MP:00053856.6ACE, FAS, FASLG, IL10, IL18, IL1A
11MP:00107686.2ACE, FAS, FASLG, IL10, IL18, IL1B
12MP:00053976.0ACE, FAS, FASLG, IL10, IL18, IL1A
13MP:00053766.0ACE, FAS, FASLG, IL10, IL18, IL1A
14MP:00053875.8ACE, FAS, FASLG, IL10, IL18, IL1A

Publications for Silicosis

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Articles related to Silicosis:

(show top 50)    (show all 595)
idTitleAuthorsYear
1
Naturally occurring genetic variation that prevents prion disease is identified. (26071523)
2015
2
A case of classic neuromyelitis optica (Devic's syndrome) triggered by pegylated-interferon I+. (25271052)
2014
3
Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression. (24107450)
2013
4
Primary leiomyosarcoma of the thyroid. (23833760)
2013
5
Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-amplified neuroblastoma. (22907398)
2013
6
First report of the genetic background of Marfan syndrome in two Polish patients. (24162367)
2013
7
Microwave and magnetic (M(2) ) proteomics of the experimental autoimmune encephalomyelitis animal model of multiple sclerosis. (23161666)
2012
8
Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management. (20393007)
2010
9
Solution structure of the C-terminal domain of multiprotein bridging factor 1 (MBF1) of Trichoderma reesei. (19137618)
2009
10
Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor. (19525444)
2009
11
BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis. (19111544)
2009
12
Concealed neo-aortic incompetence and new right ventricular outflow tract obstruction after arterial switch operation in a late presenter. (17919974)
2008
13
Antagonism of type-1 cannabinoid receptors: good for obesity, but is it safe for fertility? (17302885)
2007
14
A patient with de novo tuberculosis during anti-tumor necrosis factor-alpha therapy illustrating diagnostic pitfalls and paradoxical response to treatment. (17990230)
2007
15
The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA. (17085778)
2006
16
Strongyloidiasis stercoralis: is it a health problem in Saudi Arabia? (17366869)
2006
17
Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors. (16385588)
2006
18
Influence of the R22H variant of macrophage inflammatory protein 1beta/Lag-1 in HIV-1 survival. (15867499)
2005
19
Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor. (16220982)
2005
20
Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription. (16135786)
2005
21
Effects of surgical adductor releases for hip subluxation in cerebral palsy: an AACPDM evidence report. (15344524)
2004
22
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. (15326357)
2004
23
Inactivation of the Mgat1 gene in oocytes impairs oogenesis, but embryos lacking complex and hybrid N-glycans develop and implant. (15509794)
2004
24
Upper and lower eyelid reconstruction for severe disfiguring necrobiotic xanthogranuloma. (15513024)
2004
25
Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I. (12421824)
2003
26
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. (12882902)
2003
27
Neuroleptic malignant syndrome: uncommon postoperative diagnostic dilemma. (12538292)
2002
28
Bilateral prepapillary loops with unilateral branch retinal artery occlusion following thrombus at the loop apex. (11217933)
2001
29
c-Jun potentiates the functional interaction between the amino and carboxyl termini of the androgen receptor. (11577103)
2001
30
The transient expression of C-C chemokine receptor 8 in thymus identifies a thymocyte subset committed to become CD4+ single-positive T cells. (11123295)
2001
31
Comparative evaluation of the in vitro activity of three combinations of beta-lactams with beta-lactamase inhibitors: piperacillin/tazobactam, ticarcillin/clavulanic acid and ampicillin/sulbactam. (10788842)
2000
32
Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels. (10822281)
2000
33
Development and characterization of antibodies specific to caspase-3-produced alpha II-spectrin 120 kDa breakdown product: marker for neuronal apoptosis. (10825575)
2000
34
Focal cortical dysplasia in children. (10575250)
1999
35
Defective activation of p21ras in peripheral blood mononuclear cells from patients with insulin dependent diabetes mellitus. (10433077)
1999
36
Detection of Chlamydia trachomatis in peripheral blood leukocytes of reactive arthritis patients by polymerase chain reaction. (9778233)
1998
37
A boy with psychosocial short stature followed up from infancy to adulthood. (7793271)
1995
38
Subcutaneous calcifications in diffuse idiopathic skeletal hyperostosis. (7774094)
1995
39
Dermatologic emergencies. When early recognition can be lifesaving. (8022718)
1994
40
Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. (8037772)
1994
41
Leptospirosis with acute acalculous cholecystitis and pancreatitis. (8421147)
1993
42
Ondansetron and VIPoma. (8392671)
1993
43
Possible association between anti-Ro antibodies and myocarditis or cardiac conduction defects in adults with systemic lupus erythematosus. (2396870)
1990
44
Platelet-derived growth factor-stimulated c-myc RNA accumulation in MG-63 human osteosarcoma cells is independent of both protein kinase A and protein kinase C. (1688464)
1990
45
Lymphoepithelioma-like carcinoma of the lung. (2546459)
1989
46
Neonatal hemochromatosis: failure of deferoxamine therapy. (3681586)
1987
47
Toxic-oil syndrome. Epidemic with an elusive etiology. (4028841)
1985
48
Feline cystitis, urethritis, urethral obstruction syndrome. Part III. Prophylaxis. (27715)
1978
49
Hiatus hernia. (5302616)
1968
50

Variations for Silicosis

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Expression for genes affiliated with Silicosis

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Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL1B, TGFB1
29.7FAS, FASLG, TNF
39.5IL1A, IL1B, TNF
4
Show member pathways
9.5CXCL8, FASLG, TNF
59.3FAS, FASLG, TGFB1, TNF
69.3FAS, FASLG, TGFB1, TNF
79.3FASLG, IL1A, IL1B, TNF
89.2IL18, IL1A, IL1B
99.2IL18, IL1B, TNF
109.2IL18, IL1B, TNF
119.2IL1A, IL1B, TGFB1, TNF
12
Show member pathways
9.1CXCL8, IL1A, IL1B, TNF
13
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
14
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
159.0CXCL8, IL1A, IL1B, TGFB1
169.0IL10, TGFB1, TNF
17
Show member pathways
8.9FAS, FASLG, IL1A, TNF, TNFRSF6B
18
Show member pathways
8.8FAS, FASLG, IL1A, TNF, TNFRSF6B
19
Show member pathways
8.7CXCL8, IL18, IL1B, TNF
208.7CXCL8, IL18, IL1B, TNF
218.7IL10, IL1A, IL1B, TNF
228.7CXCL8, IL1A, IL1B, TGFB1, TNF
238.7CXCL8, IL1A, IL1B, TGFB1, TNF
248.7FAS, FASLG, IL1A, IL1B, TGFB1, TNF
258.6IL10, IL1B, TGFB1, TNF
26
Show member pathways
8.5FAS, FASLG, IL10, TGFB1, TNF
27
Show member pathways
8.4IL10, IL18, IL1B, TNF
288.4IL10, IL18, IL1B, TNF
29
Show member pathways
8.3CXCL8, FAS, FASLG, IL1B, SFTPD, TNF
308.3IL10, IL1A, IL1B, TGFB1, TNF
31
Show member pathways
8.3IL10, IL1A, IL1B, TGFB1, TNF
328.2CXCL8, IL10, IL1A, IL1B, TNF
33
Show member pathways
8.2CXCL8, FAS, FASLG, IL1A, IL1B, TGFB1
348.2CXCL8, IL10, IL1B, TGFB1, TNF
35
Show member pathways
8.1CXCL8, IL18, IL1A, IL1B, IL1RN, TNF
36
Show member pathways
8.1CXCL8, IL18, IL1A, IL1B, IL1RN, TNF
378.1CXCL8, IL18, IL1A, IL1B, TGFB1, TNF
38
Show member pathways
8.0IL10, IL18, IL1B, TGFB1, TNF
39
Show member pathways
8.0CXCL8, FAS, FASLG, IL18, IL1A, IL1B
407.9CXCL8, IL10, IL1A, IL1B, IL1RN, TNF
417.9FAS, FASLG, IL10, IL18, IL1B, TNF
427.7IL10, IL18, IL1A, IL1B, TGFB1, TNF
43
Show member pathways
7.6CXCL8, IL10, IL18, IL1A, IL1B, TNF
447.5CXCL8, IL10, IL18, IL1B, TGFB1, TNF
45
Show member pathways
7.3ACE, CXCL8, FAS, FASLG, IL10, IL1B
46
Show member pathways
7.2FAS, FASLG, IL10, IL18, IL1A, IL1B
47
Show member pathways
6.8CXCL8, FAS, FASLG, IL10, IL18, IL1A
48
Show member pathways
6.8CXCL8, FAS, FASLG, IL10, IL18, IL1A
49
Show member pathways
6.2CXCL8, FAS, FASLG, IL10, IL18, IL1A
50
Show member pathways
6.2CXCL8, FAS, FASLG, IL10, IL18, IL1A

GO Terms for genes affiliated with Silicosis

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Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idNameGO IDScoreTop Affiliating Genes
1response to growth factorGO:007084810.6FAS, FASLG
2fever generationGO:000166010.6IL1A, IL1B
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IL1B, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IL1B, TNF
5sequestering of triglycerideGO:003073010.5IL1B, TNF
6regulation of establishment of endothelial barrierGO:190314010.5IL1B, TNF
7positive regulation of chemokine biosynthetic processGO:004508010.5IL1B, TNF
8positive regulation of interleukin-2 biosynthetic processGO:004508610.5IL1A, IL1B
9positive regulation of protein complex assemblyGO:003133410.5TGFB1, TNF
10positive regulation of fever generationGO:003162210.5IL1B, TNF
11negative regulation of lipid catabolic processGO:005099510.5IL1B, TNF
12response to ozoneGO:001019310.4IL1B, SCGB1A1
13mononuclear cell proliferationGO:003294310.4ACE, TGFB1
14regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.4IL1B, TNF
15necroptotic signaling pathwayGO:009752710.4FAS, FASLG, TNF
16protein import into nucleus, translocationGO:000006010.3TGFB1, TNF
17extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.2FAS, IL1A, IL1B
18positive regulation of interleukin-17 productionGO:003274010.2IL18, TGFB1
19negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.2IL1A, IL1B, TNF
20cellular response to organic cyclic compoundGO:007140710.1FAS, TGFB1, TNF
21positive regulation of granulocyte macrophage colony-stimulating factor productionGO:003272510.1IL18, IL1B
22receptor biosynthetic processGO:003280010.0IL10, TNF
23negative regulation of cytokine secretion involved in immune responseGO:000274010.0IL10, TNF
24transformed cell apoptotic processGO:000692710.0FAS, TNF
25positive regulation of apoptotic processGO:00430659.9FAS, IL1B, TNF
26activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.9FAS, FASLG, TNF
27positive regulation of protein phosphorylationGO:00019349.8IL1B, TGFB1, TNF
28negative regulation of gene expressionGO:00106299.8IL1B, TGFB1, TNF
29positive regulation of interferon-gamma productionGO:00327299.7IL18, IL1B, TNF
30extrinsic apoptotic signaling pathwayGO:00971919.7FAS, FASLG, TGFB1, TNF
31type 2 immune responseGO:00420929.7IL10, IL18
32cellular response to lipopolysaccharideGO:00712229.6CXCL8, IL1B, TNF
33apoptotic signaling pathwayGO:00971909.6FAS, FASLG, TNF, TNFRSF6B
34lipopolysaccharide-mediated signaling pathwayGO:00316639.5IL18, IL1B, TGFB1
35positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL10, IL1B, TNF
36response to glucocorticoidGO:00513849.3FAS, IL10, IL1B, TNF
37negative regulation of transcription from RNA polymerase II promoterGO:00001229.3FASLG, IL1B, SCGB1A1, TGFB1, TNF
38MAPK cascadeGO:00001659.2IL18, IL1B, TGFB1, TNF
39negative regulation of T cell proliferationGO:00421309.1IL10, SCGB1A1, SFTPD, TGFB1
40agingGO:00075689.1FAS, IL10, IL1B, TGFB1
41defense response to bacteriumGO:00427429.0IL10, SFTPD, TNF
42regulation of cell proliferationGO:00421279.0FAS, TGFB1, TNF, TNFRSF6B
43response to drugGO:00424939.0IL10, IL1B, SCGB1A1, TGFB1
44cell-cell signalingGO:00072678.8FASLG, IL10, IL18, IL1B
45response to organic substanceGO:00100338.6IL10, SCGB1A1, TGFB1, TNF
46positive regulation of gene expressionGO:00106288.6IL18, IL1A, IL1B, TGFB1
47positive regulation of transcription from RNA polymerase II promoterGO:00459448.4IL10, IL1A, IL1B, TGFB1, TNF
48inflammatory responseGO:00069548.1IL10, IL18, IL1A, IL1B, TGFB1, TNF
49response to lipopolysaccharideGO:00324968.0FAS, FASLG, IL10, IL1B, SCGB1A1, TNFRSF6B
50immune responseGO:00069557.4CXCL8, FAS, FASLG, IL10, IL18, IL1A

Sources for Silicosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet