MCID: SLC006
MIFTS: 58

Silicosis malady

Rare diseases, Respiratory diseases categories
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Summaries for Silicosis

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NIH Rare Diseases:42 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 11/3/2010

MalaCards based summary: Silicosis, also known as pneumoconiosis due to silicates, is related to pemphigus vulgaris and systemic lupus erythematosus. An important gene associated with Silicosis is FASLG (Fas ligand (TNF superfamily, member 6)), and among its related pathways are Signal transduction JNK pathway and FAS (CD95) signaling pathway. The compounds (glc)4 and atpo have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and bone, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:8 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:65 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Aliases & Classifications for Silicosis

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Silicosis, Aliases & Descriptions:

Name: Silicosis 30 8 42 10 44 62
Pneumoconiosis Due to Silicates 8 62
Pneumoconiosis Due to Silica 8 62
Silicotic Fibrosis of Lung 8 62
Silicotuberculosis 8 62
Chronic Silicosis 42 62
 
Acute Silicosis 42 62
Pneumoconiosis Due to Other Silica 8
Silica Pneumoconiosis Nos 8
Experimental Silicosis 42
Accelerated Silicosis 42
Silicates 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:10325
NCIt39 C3369
ICD9CM27 502
MeSH34 D012829

Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1pemphigus vulgaris30.4IL1A, DSG1
2systemic lupus erythematosus30.4FAS, FASLG, IL1RN
3sarcoidosis30.2SCGB1A1, IL1RN, IL1A
4hepatitis30.2FAS, FASLG
5interstitial lung disease30.1IL1A, IL1RN
6lymphopenia30.0FASLG, IL1RN, FAS
7dermatomyositis30.0IL1RN, IL1A
8polymyositis30.0IL1A, IL1RN
9dermatitis29.9DSG1, IL1A
10idiopathic pulmonary fibrosis29.7IL1RN, IL1A, FASLG, SCGB1A1
11lung cancer10.8
12tuberculosis10.7
13pneumoconiosis10.6
14asbestosis10.6
15pneumothorax10.4
16uveitis10.4IL1A
17pulmonary tuberculosis10.3
18toxic epidermal necrolysis10.3FAS, FASLG
19vogt-koyanagi-harada disease10.3FASLG, FAS
20lymphomatoid papulosis10.3FAS, FASLG
21stevens-johnson syndrome10.3FASLG, FAS
22autoimmune lymphoproliferative syndrome10.3FAS, FASLG
23spontaneous pneumothorax10.3
24aplastic anemia10.3FAS, FASLG
25acute graft versus host disease10.3FASLG, IL1RN
26viral hepatitis10.3FAS, FASLG
27type 1 diabetes mellitus10.2IL1RN, FASLG
28autoimmune thyroiditis10.2FAS, FASLG
29graft versus host disease10.2FAS, FASLG
30bronchopulmonary dysplasia10.2SCGB1A1, IL1RN
31lupus erythematosus10.2
32pulmonary function10.2
33esophageal cancer10.2DSG1, FASLG
34bronchitis10.2
35pemphigus10.2
36berylliosis10.2
37anthracosis10.2
38connective tissue disease10.2
39alopecia areata10.2IL1A, IL1RN
40sjogren's syndrome10.1FAS, FASLG
41cerebral malaria10.1IL1RN, IL1A
42juvenile rheumatoid arthritis10.1IL1RN, IL1A
43nephritis10.1IL1RN, SCGB1A1
44periodontitis10.1IL1RN, IL1A
45gastric adenocarcinoma10.1FASLG, FAS, IL1RN
46myositis10.1IL1RN, IL1A
47bagassosis10.1
48pancreatitis10.1
49pneumonia10.1
50blindness10.1

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Symptoms for Silicosis

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Drugs & Therapeutics for Silicosis

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Drug clinical trials:

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Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

32
Lung, Lymph node, Bone, Testes, Neutrophil, Kidney, T cells, Bone marrow, Eye, Brain, Smooth muscle, Liver, Pancreas, Skin

Animal Models for Silicosis or affiliated genes

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MGI Mouse Phenotypes related to Silicosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5SCGB1A1, FAS, FASLG, IL1A
2MP:00053978.0IL1A, IL11RA, IL1RN, FASLG, FAS
3MP:00053857.7FAS, FASLG, IL1RN, IL11RA, IL1A
4MP:00053877.6IL1A, IL11RA, IL1RN, FASLG, FAS, SCGB1A1

Publications for Silicosis

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Articles related to Silicosis:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People. (25374205)
2014
2
Joint effects of smoking and silicosis on diseases to the lungs. (25105409)
2014
3
Cryptococcosis, silicosis, and tuberculous pseudotumor in the same pulmonary lobe. (24310636)
2013
4
Erasmus syndrome: silicosis and systemic sclerosis. (24051915)
2013
5
Silicosis in sandblasters of shipyard versus silicosis in stone carvers in Brazil: a comparison of imaging findings, lung function variables and cardiopulmonary exercise testing parameters. (22717312)
2012
6
Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. (21346639)
2011
7
Silicotuberculosis and silicosis as occupational diseases: report of two cases. (21980669)
2011
8
Silicosis in automobile foundry workers: a 29-year cohort study. (20514987)
2010
9
A brief review of silicosis in the United States. (20523881)
2010
10
Silicosis among agate workers at Shakarpur: An analysis of clinic-based data. (21139719)
2010
11
Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners. (19882740)
2009
12
Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. (19568841)
2009
13
FDG PET findings in a case with acute pulmonary silicosis. (19866335)
2009
14
Effect of silicosis alveolar macrophages on expression of c-myc in human embryo lung fibroblast in vitro]. (19358757)
2008
15
The value of high resolution computed tomography in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to radiography. (18667790)
2008
16
Silicosis caused by sandblasting of jeans in Turkey: a report of two concomitant cases. (16096363)
2005
17
The recognition of silicosis: labor unions and physicians in the Chilean copper industry, 1930s-1960s. (16327085)
2005
18
Progressive massive fibrosis secondary to pulmonary silicosis appearance on F-18 fluorodeoxyglucose PET/CT. (15483503)
2004
19
Tracheobronchopathia osteochondroplastica in a patient with silicosis: CT, bronchoscopy, and pathology findings. (15538154)
2004
20
Silicosis prevalence and exposure-response relations in South African goldminers. (15377766)
2004
21
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. (14514471)
2003
22
Silicosis in 76 men: qualitative and quantitative CT evaluation--clinical-radiologic correlation study. (12954899)
2003
23
The histogenesis of experimental silicosis. I--Methods for the histological evaluation of experimentally induced dust lesions. (2). 1960. (11899939)
2001
24
Silicosis and tuberculosis among South African goldminers--an overview of recent studies and current issues. (11544967)
2001
25
Accelerated silicosis in workers exposed to agate dust in Guangzhou, China. (11439400)
2001
26
Cohort mortality study of North American industrial sand workers. II. Case-referent analysis of lung cancer and silicosis deaths. (11295143)
2001
27
IgG subclass responses in experimental silicosis. (11570675)
2001
28
Mast cell basic fibroblast growth factor in silicosis. (10852784)
2000
29
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis. (10905501)
2000
30
Centennial photo page. Silicosis and a few of the other pneumoconiosies: observations on certain aspects of the problem, with emphasis on the role of the radiologist. 1958. (10915663)
2000
31
Pemphigus foliaceus associated with silicosis. (10951170)
2000
32
Cost-effectiveness of hospital discharge records for reaching selected endpoints in the surveillance of silicosis. (9787853)
1998
33
Persistent overexpression of interleukin-1beta and tumor necrosis factor-alpha in murine silicosis. (9546746)
1998
34
Silicosis deaths among young adults--United States, 1968-1994. (9583901)
1998
35
Systemic lupus erythematosus arising in a patient with chronic silicosis. (9032822)
1997
36
Photosensitivity and autoantibodies to Sm, Ro, and La in a patient with silicosis. (8876307)
1996
37
Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: studies of transforming growth factor beta expression. (8621163)
1996
38
Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography. (8800444)
1996
39
Silicosis in Brazilian pit diggers: relationship between dust exposure and radiologic findings. (7747743)
1995
40
Mortality among persons with silicosis reported to disease surveillance systems in Michigan and New Jersey in the United States. (8929696)
1995
41
The epidemiology of tuberculosis in gold miners with silicosis. (7952577)
1994
42
Cor pulmonale and silicosis: a necropsy based case-control study. (8329320)
1993
43
Correlation between radiological and pathological diagnosis of silicosis: an autopsy population based study. (8250062)
1993
44
Silicosis surveillance--Michigan, New Jersey, Ohio, and Wisconsin, 1987-1990. (8232180)
1993
45
Effect of prednisolone treatment in chronic silicosis. (2008993)
1991
46
Silicosis due to inhalation of domestic cleaning powder. (1681390)
1991
47
Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma. (2117968)
1990
48
Pneumoconiosis (silicosis) in the confectionery industry. (2345825)
1990
49
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
50
Berylliosis and silicosis. (14841360)
1951

Variations for Silicosis

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Expression for genes affiliated with Silicosis

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Expression patterns in normal tissues for genes affiliated with Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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Pathways related to Silicosis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7FASLG, FAS
2
Show member pathways
TRAIL signaling pathway37
9.7FASLG, FAS
39.7FASLG, FAS
4
Show member pathways
9.7FASLG, FAS
5
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.7FAS, FASLG
6
Show member pathways
9.7FAS, FASLG
79.5FASLG, IL1A
8
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
9.3IL1A, IL1RN
99.3IL11RA, IL1A
10
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
9.3FASLG, FAS, DSG1
11
Show member pathways
9.1FAS, IL1A, FASLG
12
Show member pathways
MAPK signaling pathway37
9.1FAS, IL1A, FASLG
13
Show member pathways
9.1FASLG, IL1A, FAS
14
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1IL1A, FASLG, FAS
15
Show member pathways
9.1IL1A, FASLG, FAS
16
Show member pathways
9.1IL1A, FASLG, FAS
17
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.9FASLG, TNFRSF6B, FAS
18
Show member pathways
8.9FAS, TNFRSF6B, FASLG
19
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.9FASLG, TNFRSF6B, FAS
208.9TNFRSF6B, FAS, FASLG
21
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
8.2IL1A, FASLG, FAS, TNFRSF6B
22
Show member pathways
7.7IL11RA, FAS, FASLG, IL1A, TNFRSF6B

Compounds for genes affiliated with Silicosis

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Compounds related to Silicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1(glc)44410.1FAS, FASLG
2atpo28 4411.0FAS, FASLG
3teniposide44 1110.9FASLG, FAS
4concanamycin a44 6110.8FAS, FASLG
52-chloroethyl ethyl sulfide449.8IL1A, IL1RN
6polysulfone449.8FASLG, IL1RN
7cellulose triacetate449.7IL1RN, IL1A
8imiquimod44 61 28 1112.7FASLG, IL1A
9gold sodium thiomalate449.6IL1A, IL1RN
10bromodeoxyuridine449.6SCGB1A1, FASLG, IL1RN
11cellulose acetate449.5FASLG, IL1RN
12tgf beta1449.5FASLG, FAS, IL1RN
133-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.5IL1A, FASLG, FAS
14agarose449.5FASLG, FAS, IL1RN
15gp 130449.5SCGB1A1, FAS, IL11RA
16camptothecin44 61 1111.4FAS, FASLG, IL1A
17mg 13244 6110.4FAS, IL1A, FASLG
18manganese superoxide449.4IL1RN, FASLG, IL1A
19ionomycin449.3FASLG, FAS, IL1A
20polymyxin b449.3IL1RN, IL1A
21simvastatin44 50 61 28 24 1114.3IL1A, IL1RN, FASLG
22tetracycline44 1110.1IL1A, FAS, SCGB1A1, FASLG
23ribonucleic acid449.1IL1A, IL1RN, FAS
24rapamycin449.1FASLG, IL1A, FAS
25aspartate449.0FASLG, SCGB1A1, FAS, IL1A
26hyaluronic acid44 2410.0IL1A, IL1RN, FASLG, SCGB1A1
27endotoxin449.0IL1A, SCGB1A1, FASLG, IL1RN
28morphine44 50 28 1112.0FAS, FASLG, IL1A, IL1RN
29rantes449.0IL1RN, IL1A, FASLG, FAS
30epinephrine44 24 1111.0IL1RN, IL1A, FAS, FASLG
31ascorbic acid44 2410.0IL1RN, FAS, IL1A, FASLG
32indomethacin44 28 61 1112.0FAS, FASLG, IL1A, IL1RN
33sb 20358044 619.9FAS, FASLG, IL1RN, IL1A
34vitamin d448.9FAS, IL1A, IL1RN
35cyclosporin a44 28 6110.9IL1A, FASLG, IL1RN, FAS
36progesterone44 28 61 24 1112.9IL1RN, FASLG, SCGB1A1, IL1A
37heparin44 28 24 1111.9IL1RN, FASLG, FAS, IL1A
38vitamin a44 24 1110.9IL1A, IL1RN, SCGB1A1, FAS
39cycloheximide448.9IL1RN, IL1A, FASLG, FAS
40creatinine448.9IL1A, FAS, SCGB1A1, IL1RN
41h2o2448.8FASLG, IL1RN, IL1A, FAS
42testosterone44 61 24 1111.8FASLG, FAS, IL1RN, IL1A
43dexamethasone44 50 28 1111.8FAS, FASLG, IL1A, IL1RN
44vegf448.8IL1RN, FAS, FASLG, IL1A
45paclitaxel44 50 1110.8FASLG, FAS, IL1A
46ivig448.6FASLG, FAS, DSG1, IL1A, IL1RN
47retinoic acid44 249.6IL1A, IL1RN, FASLG, DSG1, FAS
48nitric oxide44 24 1110.5FASLG, SCGB1A1, IL1A, IL1RN, FAS
49serine448.4IL1RN, IL1A, FASLG, FAS, DSG1
50phosphatidylinositol448.3IL1RN, SCGB1A1, FAS, FASLG, TNFRSF6B

GO Terms for genes affiliated with Silicosis

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Cellular components related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.8IL1A, IL1RN, FASLG, SCGB1A1, TNFRSF6B

Biological processes related to Silicosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.0FASLG, FAS
2necroptotic signaling pathwayGO:0975279.9FAS, FASLG
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.9FASLG, FAS
4extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.8FAS, FASLG
5extrinsic apoptotic signaling pathwayGO:0971919.8FAS, FASLG
6fever generationGO:0016609.6IL1A, IL1RN
7female pregnancyGO:0075659.5IL1RN, SCGB1A1
8extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5FAS, IL1A
9response to lipopolysaccharideGO:0324969.4SCGB1A1, FASLG, IL1RN
10activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.4FASLG, FAS
11response to glucocorticoidGO:0513849.3FAS, IL1RN, SCGB1A1
12immune responseGO:0069559.0IL1A, IL1RN, FASLG
13signal transductionGO:0071658.9IL11RA, FASLG, FAS, SCGB1A1
14negative regulation of apoptotic processGO:0430668.6TNFRSF6B, FAS, IL1RN
15apoptotic processGO:0069158.1IL1A, FASLG, FAS, DSG1, TNFRSF6B

Molecular functions related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.3IL1A, IL1RN

Products for genes affiliated with Silicosis

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Sources for Silicosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet