MCID: SLC006
MIFTS: 52

Silicosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

MalaCards integrated aliases for Silicosis:

Name: Silicosis 38 12 50 52 42 14 69
Silicotuberculosis 12 69
Chronic Silicosis 50 69
Acute Silicosis 50 69
Pneumoconiosis Due to Silicates 12
Silicotic Fibrosis of Lung 12
Experimental Silicosis 50
Silica Pneumoconiosis 12
Accelerated Silicosis 50

Classifications:



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Disease Ontology 12 DOID:10325
ICD10 33 J62 J62.8
ICD9CM 35 502
MeSH 42 D012829
NCIt 47 C3369
UMLS 69 C0037116

Summaries for Silicosis

NIH Rare Diseases : 50 silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. a cough, weight loss, and fatigue may also be present. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 12/17/2015

MalaCards based summary : Silicosis, also known as silicotuberculosis, is related to pneumoconiosis due to talc and pulmonary hypertension. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Isoniazid and Rifampin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and hematopoietic system

Disease Ontology : 12 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia : 72 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Related Diseases for Silicosis

Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
id Related Disease Score Top Affiliating Genes
1 pneumoconiosis due to talc 30.4 CCL2 TNF
2 pulmonary hypertension 30.3 FAS IL1B TNF
3 pulmonary tuberculosis 29.9 CCL2 CXCL8 TNF
4 mycobacterium kansasii 29.8 CXCL8 NLRP3 TNF
5 asthma 29.0 CXCL8 IL1A IL1B SCGB1A1 TNF
6 middle lobe syndrome 28.5 CCL2 CXCL8 SFTPD TGFB1
7 pulmonary embolism 28.2 CCL2 CXCL8 IL1B NLRP3 TNF
8 asbestosis 26.9 CCL2 CXCL8 FAS FASLG IL1A IL1B
9 anthracosis 11.1
10 tabatznik syndrome 10.8 IL1B TNF
11 sternal cleft 10.8 IL1B TNF
12 beryllium disease 10.8
13 interstitial lung disease 10.8
14 toxic optic neuropathy 10.8 IL1A IL1B
15 gastric cancer risk after h. pylori infection 10.7 IL1B IL1RN
16 oculomotor nerve paralysis 10.7 CXCL8 IL1B
17 juvenile sialidosis type 2 10.7 FAS FASLG
18 gastrointestinal tuberculosis 10.7 FAS FASLG
19 common peroneal nerve lesion 10.7 CXCL8 IL1B
20 basidiobolomycosis 10.7 CXCL8 TNF
21 small intestine lymphoma 10.7 IL1A TNF
22 spirillary rat-bite fever 10.6 CXCL8 TNF
23 biemond syndrome 10.6 TGFB1 TNF
24 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.6 FAS FASLG TNF
25 indolent myeloma 10.6 IL1B IL1RN TNF
26 breast adenomyoepithelioma 10.6 FAS FASLG IL1B
27 benign neonatal seizures 10.6 IL1B IL1RN TNF
28 cartilage disease 10.6 FAS TGFB1
29 lung sarcoma 10.6 IL1A IL1B TNF
30 keloids 10.6 IL1B IL1RN TNF
31 amyotrophic lateral sclerosis type 10 10.6 CXCL8 IL1B TNF
32 epulis 10.6 CXCL8 IL1B TNF
33 lymph node palisaded myofibroblastoma 10.6 CXCL8 IL1A
34 acquired thrombocytopenia 10.6 CXCL8 IL1B TNF
35 mikulicz disease 10.6 IL1A IL1B TNF
36 testicular infarct 10.6 CXCL8 IL1B TNF
37 noninfectious dermatoses of eyelid 10.6 FAS FASLG TNF
38 myeloid sarcoma 10.6 CXCL8 IL1B TNF
39 breast disease 10.6 CXCL8 IL1B TNF
40 mental retardation dysmorphism hypogonadism diabetes 10.6 IL1A IL1B IL1RN
41 endocervical type cervical mucinous adenocarcinoma 10.6 CXCL8 IL1B TNF
42 congenital insensitivity to pain with hyperhidrosis 10.6 CXCL8 IL1RN
43 bladder calculus 10.6 IL1RN TNF
44 spondylolysis 10.5 CXCL8 IL1B TNF
45 churg-strauss syndrome 10.5 CXCL8 IL1B TNF
46 glossitis 10.5 IL1A IL1B IL1RN
47 colon adenocarcinoma 10.5 CXCL8 IL1B TNF
48 sheehan syndrome 10.5 CXCL8 IL1B TNF
49 spontaneous ocular nystagmus 10.5 CXCL8 IL1B TNF
50 blue toe syndrome 10.5 CXCL8 IL1B TNF

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Heart Disease Postinflammatory Pulmonary Fibrosis
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to Silicosis

Symptoms & Phenotypes for Silicosis

GenomeRNAi Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 ACE NLRP3 CXCL8 TGFB1 FAS TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 CXCL8 TGFB1 FAS TNF FASLG TNFRSF6B

MGI Mouse Phenotypes related to Silicosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 FASLG IL1A IL1B IL1RN NLRP3 SFTPD
2 homeostasis/metabolism MP:0005376 10.06 ACE FAS FASLG IL1A IL1B IL1RN
3 immune system MP:0005387 10.03 CCL2 FAS FASLG IL1A IL1B IL1RN
4 integument MP:0010771 9.76 FAS FASLG IL1A IL1B IL1RN NLRP3
5 neoplasm MP:0002006 9.56 ACE FAS FASLG IL1A IL1B SCGB1A1
6 skeleton MP:0005390 9.23 TNF DSG1 FAS FASLG IL1B IL1RN

Drugs & Therapeutics for Silicosis

Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved Phase 3 54-85-3 3767
2
Rifampin Approved Phase 3 13292-46-1 5458213 5381226
3
Rifapentine Approved Phase 3 61379-65-5 6323497
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Anti-Infective Agents Phase 3
7 Antimetabolites Phase 3
8 Antitubercular Agents Phase 3
9 Cytochrome P-450 CYP3A Inducers Phase 3
10 Hypolipidemic Agents Phase 3
11 Lipid Regulating Agents Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13 Mitogens Phase 1, Phase 2
14 Respiratory System Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3 Weekly INH / RRT given by DOT
2 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
3 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
4 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
5 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
6 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
7 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
8 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
9 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Recruiting NCT02794701

Search NIH Clinical Center for Silicosis

Cochrane evidence based reviews: silicosis

Genetic Tests for Silicosis

Anatomical Context for Silicosis

MalaCards organs/tissues related to Silicosis:

39
Lung, Bone, Lymph Node, Bone Marrow, Testes, Neutrophil, T Cells

Publications for Silicosis

Articles related to Silicosis:

(show top 50) (show all 660)
id Title Authors Year
1
Complicated silicosis resulting from occupational exposure to engineered stone products. ( 28490299 )
2017
2
Surveillance for Silicosis Deaths Among Persons Aged 15-44 Years - United States, 1999-2015. ( 28727677 )
2017
3
What is expected in lung function after lung transplantation due to end-stage pulmonary silicosis? ( 28871617 )
2017
4
Influence of quartz exposure on lung cancer types in cases of lymph node-only silicosis and lung silicosis in German uranium miners. ( 28443719 )
2017
5
Infodemiological data concerning silicosis in the USA in the period 2004-2010 correlating with real-world statistical data. ( 28054008 )
2017
6
Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis. ( 28222740 )
2017
7
Association between SNPs at IL-17A and IL-17F and susceptibility to accelerated silicosis. ( 28481151 )
2017
8
Clinical evaluation of CENP-B and Scl-70 autoantibodies in silicosis patients. ( 28587321 )
2017
9
Imipramine blocks acute silicosis in a mouse model. ( 28893276 )
2017
10
Rapid Radiologic Progression of Silicosis. ( 28339287 )
2017
11
Silicosis prevalence and risk factors in semi-precious stone mining in Brazil. ( 28514023 )
2017
12
Plastic bronchitis in a patient with silicosis. ( 28365186 )
2017
13
Experimental silicosis does not aggravate collagen-induced arthritis in mice. ( 28285600 )
2017
14
Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis. ( 28916165 )
2017
15
A reliability and readability analysis of silicosis-related Italian websites: implications for occupational health. ( 28660869 )
2017
16
Bullous pemphigoid associated with silicosis. ( 28622458 )
2017
17
Bosutinib Therapy Ameliorates Lung Inflammation and Fibrosis in Experimental Silicosis. ( 28360865 )
2017
18
IL-10-Producing CD1d(hi)CD5(+) Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients. ( 28243231 )
2017
19
Artificial stone-associated silicosis: a rapidly emerging occupational lung disease. ( 28882991 )
2017
20
BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis. ( 28277537 )
2017
21
Tadalafil reduces airway hyperactivity and protects against lung and respiratory airways dysfunction in a rat model of silicosis. ( 27769022 )
2016
22
Radiological Evaluation of Artificial Stone Silicosis Outbreak: Emphasizing Findings in Lung Transplant Recipients. ( 27680410 )
2016
23
Dynamic changes of mononuclear phagocytes in circulating, pulmonary alveolar and interstitial compartments in a mouse model of experimental silicosis. ( 27240636 )
2016
24
Lung cancer in patients diagnosed with silicosis should be investigated. ( 27330963 )
2016
25
Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-I^1/ROCK1 pathway in silicosis in rat. ( 26785300 )
2016
26
Silicosis and silicotuberculosis in India. ( 27843169 )
2016
27
Computed Tomography and Magnetic Resonance Imaging for Longitudinal Characterization of Lung Structure Changes in a Yucatan Miniature Pig Silicosis Model. ( 26839326 )
2016
28
Biometric monitoring in silicosis to detect early disease and monitor lung injury: not quite there. ( 27995130 )
2016
29
Can silicosis explain it all? ( 27650457 )
2016
30
Deadly denim: sandblasting-induced silicosis in the jeans industry. ( 27155769 )
2016
31
A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy. ( 27516887 )
2016
32
Leveraging Big Data for Exploring Occupational Diseases-Related Interest at the Level of Scientific Community, Media Coverage and Novel Data Streams: The Example of Silicosis as a Pilot Study. ( 27806115 )
2016
33
Genome-wide analysis of aberrantly expressed microRNAs in bronchoalveolar lavage fluid from patients with silicosis. ( 26903263 )
2016
34
Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis. ( 27014274 )
2016
35
Fatal silicosis in a funeral arts' craftsman. ( 27976666 )
2016
36
Silicosis, tuberculosis time bomb? ( 27601099 )
2016
37
Recurrent Tracheal Stenosis: A Novel Presentation of Silicosis. ( 27388408 )
2016
38
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. ( 26977968 )
2016
39
Surveillance for Silicosis - Michigan and New Jersey, 2003-2011. ( 27736836 )
2016
40
Effects of bone marrow-derived mesenchymal stem cells on the autophagic activity of alveolar macrophages in a rat model of silicosis. ( 27284351 )
2016
41
Proteomic profiling differences in serum from silicosis and chronic bronchitis patients: a comparative analysis. ( 27076939 )
2016
42
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in a rare case of carcinoma stomach with concomitant silicosis. ( 27833322 )
2016
43
Endobronchial Silicosis and Tuberculosis Presenting as the Right Middle Lobe Syndrome. ( 27764010 )
2016
44
Silicosis in the form of progressive massive fibrosis: A diagnostic challenge. ( 28194086 )
2016
45
Effect of Xinjiang Uyghur Vernonia anthelmintica Willd Injection Treatment with Silicosis Fibrosis. ( 27803925 )
2016
46
Global DNA methylation and PTEN hypermethylation alterations in lung tissues from human silicosis. ( 27621875 )
2016
47
Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis. ( 26789403 )
2016
48
Silica, Silicosis, and Autoimmunity. ( 27014276 )
2016
49
Proteomic profiling change during the early development of silicosis disease. ( 27076927 )
2016
50
Denim production and silicosis. ( 26807688 )
2016

Variations for Silicosis

Expression for Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for Silicosis

Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CXCL8 DSG1 FASLG IL1A IL1B
2
Show member pathways
13.85 CCL2 CXCL8 FAS FASLG IL1A IL1B
3
Show member pathways
13.65 CCL2 CXCL8 FAS FASLG IL1A IL1B
4
Show member pathways
13.47 CXCL8 FAS FASLG IL1A IL1B TGFB1
5
Show member pathways
13.41 CCL2 CXCL8 FAS FASLG IL1A IL1B
6
Show member pathways
13.33 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
7
Show member pathways
13.29 CCL2 CXCL8 FAS FASLG IL1A IL1B
8
Show member pathways
12.99 CCL2 CXCL8 IL1A IL1B IL1RN NLRP3
9
Show member pathways
12.89 CCL2 FAS FASLG TNF TNFRSF6B
10
Show member pathways
12.84 CXCL8 FAS FASLG IL1A IL1B TGFB1
11
Show member pathways
12.73 CCL2 CXCL8 FAS FASLG IL1A IL1B
12 12.72 FAS FASLG IL1A IL1B TGFB1 TNF
13
Show member pathways
12.68 FAS FASLG IL1A IL1B TNF
14
Show member pathways
12.64 FAS FASLG IL1A IL1B TNF
15
Show member pathways
12.59 ACE CCL2 CXCL8 FAS FASLG IL1B
16
Show member pathways
12.58 IL1A IL1B TGFB1 TNF
17 12.56 CCL2 FAS FASLG IL1B IL1RN TNF
18
Show member pathways
12.45 FAS IL1A IL1B TGFB1 TNF
19
Show member pathways
12.35 CCL2 CXCL8 IL1B TNF
20
Show member pathways
12.32 CCL2 IL1A IL1B IL1RN
21 12.32 FAS FASLG TGFB1 TNF
22
Show member pathways
12.29 FAS FASLG IL1A TNF TNFRSF6B
23
Show member pathways
12.28 IL1A IL1B TGFB1 TNF
24
Show member pathways
12.28 CXCL8 IL1A IL1B TNF
25 12.25 IL1A IL1B TGFB1 TNF
26 12.2 CXCL8 IL1A IL1B IL1RN TNF
27
Show member pathways
12.18 CXCL8 IL1A IL1B TNF
28
Show member pathways
12.17 CXCL8 FAS FASLG IL1B SFTPD TNF
29 12.12 CCL2 IL1A IL1B TNF
30 12.07 IL1A IL1B TGFB1 TNF
31 11.99 CCL2 FAS IL1B TNF
32 11.98 CXCL8 IL1A IL1B TGFB1
33
Show member pathways
11.94 IL1B TGFB1 TNF
34 11.92 CXCL8 IL1B TGFB1 TNF
35 11.92 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
36 11.9 IL1A IL1B TNF
37 11.88 CXCL8 IL1B TNF
38
Show member pathways
11.86 FAS FASLG TNF TNFRSF6B
39 11.84 CXCL8 IL1A IL1B
40 11.79 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
41
Show member pathways
11.78 CXCL8 FASLG TNF
42 11.78 IL1B TGFB1 TNF
43 11.77 CXCL8 IL1A IL1B NLRP3 TNF
44
Show member pathways
11.7 CXCL8 IL1A IL1B TNF
45 11.69 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
46 11.65 CCL2 CXCL8 IL1B TGFB1 TNF
47 11.62 CXCL8 IL1B TNF
48 11.58 CXCL8 FASLG TGFB1
49 11.58 FAS FASLG TNF
50 11.55 IL1B TGFB1 TNF

GO Terms for Silicosis

Cellular components related to Silicosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ACE CCL2 CXCL8 FASLG IL1A IL1B
2 lysosome GO:0005764 9.62 ACE FASLG IL1B SFTPD
3 extracellular region GO:0005576 9.47 ACE CCL2 CXCL8 FAS FASLG IL1A
4 external side of plasma membrane GO:0009897 9.46 ACE FAS FASLG TNF
5 secretory granule GO:0030141 9.43 IL1B SCGB1A1 TGFB1

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.99 CCL2 IL1B TGFB1 TNF
2 regulation of cell proliferation GO:0042127 9.97 FAS TGFB1 TNF TNFRSF6B
3 positive regulation of protein phosphorylation GO:0001934 9.93 FAS IL1B TGFB1 TNF
4 positive regulation of angiogenesis GO:0045766 9.89 CXCL8 IL1A IL1B
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 IL1B NLRP3 TGFB1 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.88 CCL2 CXCL8 NLRP3 TNF
7 response to organic substance GO:0010033 9.87 SCGB1A1 TGFB1 TNF
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.87 FAS FASLG TNF TNFRSF6B
9 cellular response to mechanical stimulus GO:0071260 9.85 FAS IL1B TGFB1
10 neutrophil chemotaxis GO:0030593 9.85 CCL2 CXCL8 IL1B
11 positive regulation of interleukin-6 production GO:0032755 9.83 IL1A IL1B TNF
12 positive regulation of cell division GO:0051781 9.83 IL1A IL1B TGFB1
13 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.81 FAS FASLG NLRP3 TNF
14 response to progesterone GO:0032570 9.8 CCL2 DSG1 TGFB1
15 cellular response to organic cyclic compound GO:0071407 9.8 CCL2 IL1B TGFB1 TNF
16 negative regulation of T cell proliferation GO:0042130 9.79 SCGB1A1 SFTPD TGFB1
17 apoptotic signaling pathway GO:0097190 9.78 FAS FASLG TNF TNFRSF6B
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.77 IL1A IL1B TNF
19 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.76 FAS IL1A IL1B
20 extrinsic apoptotic signaling pathway GO:0097191 9.76 FAS FASLG TGFB1 TNF
21 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.73 FAS FASLG TNF
22 response to lipopolysaccharide GO:0032496 9.73 CCL2 FAS FASLG IL1B SCGB1A1 TNFRSF6B
23 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
24 positive regulation of phagocytosis GO:0050766 9.72 IL1B SFTPD TNF
25 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
26 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.71 FAS FASLG
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
29 protein kinase B signaling GO:0043491 9.71 CCL2 IL1B TGFB1 TNF
30 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.7 FAS FASLG
31 macrophage chemotaxis GO:0048246 9.7 CCL2 SFTPD
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
33 positive regulation of vascular endothelial growth factor production GO:0010575 9.7 IL1A IL1B TGFB1
34 PERK-mediated unfolded protein response GO:0036499 9.69 CCL2 CXCL8
35 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.69 IL1A IL1B
36 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
37 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.68 IL1A IL1B
38 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
39 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
40 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TGFB1 TNF
41 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
42 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.65 IL1A TGFB1
43 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
44 interleukin-1 beta production GO:0032611 9.64 IL1B NLRP3
45 positive regulation of mononuclear cell migration GO:0071677 9.64 TGFB1 TNF
46 inflammatory cell apoptotic process GO:0006925 9.61 FAS FASLG
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
48 necroptotic signaling pathway GO:0097527 9.61 FAS FASLG TNF
49 immune response GO:0006955 9.61 CCL2 CXCL8 FAS FASLG IL1A IL1B
50 response to glucocorticoid GO:0051384 9.55 CCL2 FAS IL1RN SCGB1A1 TNF

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Silicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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