MCID: SLC006
MIFTS: 53

Silicosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

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Aliases & Descriptions for Silicosis:

Name: Silicosis 34 11 47 49 38 13 67
Silicotuberculosis 11 67
Chronic Silicosis 47 67
Acute Silicosis 47 67
Pneumoconiosis Due to Silicates 11
 
Silicotic Fibrosis of Lung 11
Experimental Silicosis 47
Silica Pneumoconiosis 11
Accelerated Silicosis 47

Classifications:



External Ids:

Disease Ontology11 DOID:10325
ICD1029 J62, J62.8
ICD9CM31 502
MeSH38 D012829
NCIt44 C3369

Summaries for Silicosis

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Disease Ontology:11 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

MalaCards based summary: Silicosis, also known as silicotuberculosis, is related to pneumoconiosis due to talc and pulmonary hypertension. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways are Interleukin-1 processing and Signal transduction_JNK pathway. Affiliated tissues include lung, bone and lymph node, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Wikipedia:70 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1pneumoconiosis due to talc31.1TGFB1, TNF
2pulmonary hypertension30.2IL1B, TNF
3lymphopenia29.9CXCL8, IL1B, TNF
4asbestosis27.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
5asthma27.0CXCL8, FAS, IL1A, IL1B, IL1RN, NLRP3
6anthracosis11.1
7interstitial lung disease10.8
8thyroid malformation10.7IL1B, TNF
9hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.7IL1B, TNF
10baetz-greenwalt syndrome10.6IL1B, TNF
11pediatric systemic lupus erythematosus10.6FAS, FASLG
12diabetic cataract10.6IL1A, IL1B
13granulomatous gastritis10.6FAS, FASLG
14corneal deposit10.6CXCL8, IL1B
15basidiobolomycosis10.6CXCL8, TNF
16tarsal tunnel syndrome10.6CXCL8, IL1B
17small intestine lymphoma10.5IL1A, TNF
18gastric cancer risk after h. pylori infection10.5IL1B, IL1RN
1912p12.1 microdeletion syndrome10.5FAS, FASLG, TNF
20cartilage disease10.5IL1B, TNF
21maligant granulosa cell tumor of ovary10.5CXCL8, TNF
22parsonage turner syndrome10.5TGFB1, TNF
23calpainopathy10.5FAS, TGFB1
24myopathy-growth delay-intellectual disability-hypospadias syndrome10.5TGFB1, TNF
25non-secretory myeloma10.5IL1B, IL1RN, TNF
26benign breast adenomyoepithelioma10.5FAS, FASLG, IL1B
27keloids10.5IL1B, IL1RN, TNF
28epstein-barr virus hepatitis10.5IL1A, TNF
29senile cataract10.5IL1B, IL1RN, TNF
30rectosigmoid junction neoplasm10.5IL1A, IL1B, TNF
31skin disease10.4CXCL8, IL1B, TNF
32benign lymphoepithelial lesion of salivary gland10.4IL1A, IL1B, TNF
33sternum lymphoma10.4IL1B, IL1RN, TNF
34paraphimosis10.4CXCL8, IL1B, TNF
35qualitative platelet defect10.4CXCL8, IL1B, TNF
36paraneoplastic polyneuropathy10.4CXCL8, IL1B, TNF
37inner ear cancer10.4CXCL8, IL1B, TNF
38duodenum cancer10.4FAS, TNF
39benign adult familial myoclonic epilepsy10.4CXCL8, FAS
40kidney angiomyolipoma10.4CXCL8, IL1B, TNF
41cervix erosion10.4CXCL8, IL1B, TNF
42intestinal variant cervical mucinous adenocarcinoma10.4CXCL8, IL1B, TNF
43mental retardation anophthalmia craniosynostosis10.4IL1A, IL1B, IL1RN
44dementia - subcortical10.4CXCL8, FAS, TNF
45bacteriuria10.4CXCL8, IL1B, TNF
46contact blepharoconjunctivitis10.4CXCL8, IL1B
47amelogenesis imperfecta10.4CXCL8, IL1B, TNF
48mononeuritis of lower limb10.4CXCL8, IL1B, TNF
49lateral sclerosis10.4CXCL8, IL1B, TNF
50mandibular cancer10.4CXCL8, IL1B, TNF

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


AnthracosisProstatic Hypertrophy
Respiratory FailureHeart Disease
Postinflammatory Pulmonary FibrosisBronchitis

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Symptoms for Silicosis

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Drugs & Therapeutics for Silicosis

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Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IsoniazidapprovedPhase 315054-85-33767
Synonyms:
37271-10-6
4-pyridinecarbohydrazide
41466-07-3
5015 R.P
5015 R.P.
5015 RP
54-85-3
62229-51-0
7640-37-1
AB00052025
AC1L1GNZ
AC1Q54UP
AC1Q54UQ
AI3-23936
AKOS000119062
AZT + Isoniazid
Abdizide
Andrazide
Anidrasona
Antimicina
Antituberkulosum
Armacide
Armazid
Armazide
Atcotibine
Azuren
BB_SC-6246
BIDD:GT0140
BP 5015
BPBio1_000025
BPBio1_001322
BSPBio_000021
BSPBio_002204
Bacillin
Biomol-NT_000288
C07054
C6H7N3O
CAS-54-85-3
CCRIS 351
CHEBI:6030
CHEMBL64
CID3767
CPD000059082
Cedin
Cedin (Aerosol)
Cemidon
Chemiazid
Chemidon
Continazine
Cortinazine
Cotinazin
Cotinizin
D00346
D007538
DB00951
Defonin
Dibutin
Diforin
Dinacrin
Ditubin
DivK1c_000070
Dow-Isoniazid
EINECS 200-214-6
Ebidene
Eralon
Ertuban
Eutizon
Evalon
FRS-3
FSR 3
FSR-3
Fetefu
Fimalene
GINK
HIA
HMS1568B03
HMS1920H09
HMS2089I16
HMS2091N19
HMS500D12
HSDB 1647
Hid rasonil
Hidranizil
Hidrasonil
Hidrulta
Hidrun
Hycozid
Hydra
Hydrazid
Hydrazide
Hyozid
Hyzyd
I.A.I
I.A.I.
I0138
I14-9731
I3377_FLUKA
I3377_SIGMA
IDI1_000070
INH
INHd20
Ido-tebin
Idrazil
In-73
Inah
Inh-Burgthal
Inizid
Iscotin
Isidrina
Ismazide
Isobicina
Isocid
Isocidene
Isocotin
Isohydrazide
Isokin
Isolyn
Isonerit
Isonex
Isoniacid
Isoniazid
Isoniazid & EEP
Isoniazid & Propolis
Isoniazid SA
Isoniazida
Isoniazide
Isoniazidum
Isonicazide
Isonicid
Isonico
Isonicotan
Isonicotil
Isonicotinhydrazid
Isonicotinic acid hydrazide
Isonicotinic hydrazide
Isonicotinohydrazide
Isonicotinoyl hydrazide
Isonicotinoylhydrazide
Isonicotinsaeurehydrazid
Isonicotinyl hydrazide
Isonicotinyl hydrazine
Isonicotinylhydrazine
Isonide
Isonidrin
Isonikazid
Isonilex
Isonin
Isonindon
Isonirit
Isoniton
Isonizida
Isonizide
Isopyrin
 
Isotamine
Isotebe
Isotebezid
Isotinyl
Isozid
Isozide
Isozyd
KBio1_000070
KBio2_001333
KBio2_003901
KBio2_006469
KBio3_001424
KBioGR_000423
KBioSS_001333
L 1945
LANIZID
LS-205
Laniazid
Laniazid (TN)
Laniozid
MLS000069444
MLS001055327
MolPort-000-141-557
Mybasan
NCGC00016244-01
NCGC00016244-02
NCGC00022648-03
NCGC00022648-04
NCGC00022648-05
NCGC00022648-06
NINDS_000070
NSC 9659
NSC9659
Neo-Tizide
Neoteben
Neoxin
Neumandin
Nevin
Niadrin
Nicazide
Nicetal
Nicizina
Niconyl
Nicotibina
Nicotibine
Nicotisan
Nicozide
Nidaton
Nidrazid
Nikozid
Niplen
Nitadon
Niteban
Nitebannsc 9659
Nydrazid
Nyscozid
Oprea1_396155
Pelazid
Percin
Phthisen
Preparation 6424
Prestwick0_000161
Prestwick1_000161
Prestwick2_000161
Prestwick3_000161
Prestwick_578
Pycazide
Pyreazid
Pyricidin
Pyridicin
Pyridine-4-carboxylic acid hydrazide
Pyrizidin
RP 5015
RP-5015
RU-EF-Tb
RY-EF-Tb
Raumanon
Razide
Retozide
Rifamate
Rimicid
Rimifon
Rimiphone
Rimitsid
Robiselin
Robisellin
Roxifen
S1937_Selleck
SAM002554904
SMR000059082
SPBio_000094
SPBio_001942
SPECTRUM1500355
STK086288
Sanohidrazina
Sauterazid
Sauterzid
Spectrum2_000107
Spectrum3_000472
Spectrum4_000022
Spectrum5_000876
Spectrum_000853
Stanozide
TB-Phlogin
TB-Razide
TB-Vis
Tebecid
Tebenic
Tebexin
Tebilon
Tebos
Teebaconin
Tekazin
Tibazide
Tibemid
Tibiazide
Tibinide
Tibison
Tibivis
Tibizide
Tibusan
Tisin
Tisiodrazida
Tizide
Tubazid
Tubazide
Tubeco
Tubecotubercid
Tuberian
Tubicon
Tubilysin
Tubizid
Tubomel
Tyvid
UNII-V83O1VOZ8L
Unicocyde
Unicozyde
Usaf cb-2
Vazadrine
Vederon
WLN: T6NJ DVMZ
ZINC00001590
Zidafimia
Zinadon
Zonazide
bacillen
bp 5 015
isoco tin
isoniazid
isozid e
nchembio884-comp3
nidra zid
rimif on
tebemid
tubercid
2
RifampinapprovedPhase 333713292-46-15458213, 5381226
Synonyms:
1-b]furan-21-yl acetate
13292-46-1
3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(4-Methylpiperazinyliminomethyl)-rifamycin SV
3-(4-Methylpiperazinyliminomethyl)rifamycin SV
3-([(4-Methyl-1-piperazinyl)imino]methyl)rifamycin SV
3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV
3-[[(4-Methyl-1-piperazinyl)imino]-methyl]rifamycin
46713_FLUKA
46713_RIEDEL
62534-43-4
8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
8-(4-Methylpiperazinyliminomethyl) rifamycin SV
8-[[(4-Methyl-1-piperazinyl)imino[methyl]rifamycin
8-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin sv
8-[[(4-Methylpiperazinyl)imino]methyl]rifamycin sv
83907_FLUKA
83907_SIGMA
8CI)
AZT + Rifampin
Abrifam
Archidyn
Arficin
Arzide
BA-41166E
BIDD:PXR0014
BPBio1_000561
BSPBio_000509
Ba 41166
Ba 41166/E
Benemicin
Benemycin
Bio-0621
C06688
C43H58N4O12
CAS-13292-46-1
CCRIS 551
CHEBI:28077
CHEBI:455936
CHEMBL180
CID5381226
CID5388984
CID5458213
CID5702112
CID6604339
CID6708473
CID6842115
CID6912767
CID6913622
CPD001906767
D00211
DB01045
DRG-0109
Dione 21-acetate
Dipicin
DivK1c_000550
Doloresum
EINECS 236-312-0
Eremfat
Famcin
Fenampicin
HMS1569J11
HMS1920P08
HMS2089F12
HMS2092G09
HMS501L12
HSDB 3181
KBio1_000550
KBio2_000919
KBio2_003487
KBio2_006055
KBio3_003018
KBioGR_001780
KBioSS_000919
L-5103
L-5103 Lepetit
LS-7689
MLS000028552
MLS001148237
MLS001333745
MolPort-000-767-051
MolPort-002-513-586
MolPort-003-666-281
MolPort-006-395-891
NCGC00016699-01
NCGC00017365-01
NCGC00018178-01
NCGC00022678-03
NCGC00022678-04
NCGC00022678-05
NCGC00160500-01
 
NCI60_000309
NINDS_000550
NSC 113926
NSC-113926
NSC113926
Piperine & Rifampicin
Prestwick0_000525
Prestwick1_000525
Prestwick2_000525
Prestwick3_000525
Prestwick_833
R-Cin
R/AMP
R0079
R3501_SIAL
R3501_SIGMA
R5777_SIGMA
R7382_SIGMA
RAMP
RFP
RMP
Ramp
Reserpine & Rifampicin
Rf
Rfamipicin
Rifa
Rifadin
Rifadin (TN)
Rifadin I.V
Rifadin I.V.
Rifadin IV
Rifadin Iv
Rifadin, Rimactane, Rifampicin, Rifampin
Rifadine
Rifagen
Rifaldazin
Rifaldazine
Rifaldin
Rifam
Rifamicin AMP
Rifamor
Rifampicin
Rifampicin & EEP
Rifampicin & Propolis
Rifampicin (JP15/INN)
Rifampicin SV
Rifampicin [INN:BAN:JAN]
Rifampicina
Rifampicina [INN-Spanish]
Rifampicine
Rifampicine [French]
Rifampicinum
Rifampicinum [INN-Latin]
Rifampin
Rifampin (USP)
Rifampin [USAN]
Rifamsolin
Rifamycin
Rifamycin AMP
Rifamycin Amp
Rifaprodin
Rifcin
Rifinah
Rifobac
Rifoldin
Rifoldine
Riforal
Rimactan
Rimactane
Rimactane (TN)
Rimactazid
Rimactin
Rimactizid
Rimazid
Rimycin
Rofact
S1764_Selleck
SAM002264646
SMR000058322
SMR000653525
SPBio_002430
SPECTRUM1500529
STK080143
Sinerdol
Spectrum3_001837
Spectrum4_001250
Spectrum5_002018
Spectrum_000439
TNP00313
Tubocin
UNII-VJT6J7R4TR
WLN: V1 WQ A&1 E&1 E1UN- AT6N DNTJ D1
nchembio884-comp4
rifampin
3
RifapentineapprovedPhase 33061379-65-56323497
Synonyms:
(2R,16S,17R,18R,19R,20S,21S,22S,23S)-8-{[(4-CYCLOPENTYLPIPERAZIN-1-YL)IMINO]METHYL}-5,6,9,17,19-PENTAHYDROXY-23-METHOXY-2,4,12,16,18,20,22-HEPTAMETHYL-1,11-DIOXO-1,2-DIHYDRO-2,7-(EPOXYPENTADECA[1,11,13]TRIENOIMINO)NAPHTHO[2,1-B]FURAN-21-YL ACETATE
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV
3-(N-(4-Cyclopentyl-1-piperazinyl)formimidoyl)rifamycin
3-[N-(4-Cyclopentyl-1-piperazinyl)formimidoyl]rifamycin
61379-65-5
71950-35-1
Ambap127923-87-9
Antibiotic DL 473IT
BIDD:GT0669
C08059
C47H64N4O12
CHEBI:45304
CHEMBL1660
CID6323497
CID6434610
CID6835847
CID9919168
CPD000466332
CPD001906779
Cyclopentyl rifampin
Cyclopentylrifampicin
D00879
DB01201
DL 473
DL 473-IT
DL-4-73
DL-473
DL473
DRG-0283
 
EINECS 262-743-9
HMS2051D16
KTC 1
LS-143825
M000473
MDL 473
MDL-473
MDL473
MLS000759441
MLS001424209
NCGC00167431-01
Priftin
Priftin (TN)
Priftin (tn)
Priftin, Cyclopentylrifampicin, Rifapentine
R 77-3
R-773
RIFAPENTINE
RPE
RPT
Rifamycin AF/ACPP
Rifapentin
Rifapentina
Rifapentina [Spanish]
Rifapentine (USAN/INN)
Rifapentine [USAN:BAN:INN]
Rifapentinum
Rifapentinum [Latin]
S1760_Selleck
SAM001246620
SAM002589953
SMR000466332
UNII-XJM390A33U
4Lipid Regulating AgentsPhase 32702
5Nucleic Acid Synthesis InhibitorsPhase 34855
6Anti-Bacterial AgentsPhase 310884
7Hypolipidemic AgentsPhase 32721
8Antibiotics, AntitubercularPhase 36972
9Cytochrome P-450 CYP3A InducersPhase 31101
10Anti-Infective AgentsPhase 321402
11AntimetabolitesPhase 311774
12Antitubercular AgentsPhase 31272
13MitogensPhase 1, Phase 21526
14Respiratory System Agents4818

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis PreventionRecruitingNCT02430259Phase 3
2Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat SilicosisCompletedNCT01977131Phase 1, Phase 2
3Safety of Stem Cells Intrabronchial Instillation for SilicosisCompletedNCT01239862Phase 1
4A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem CellsRecruitingNCT02668068Phase 1
5Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone)Unknown statusNCT01338064
6DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone)Unknown statusNCT01329003
7Oscillation Mechanics of the Respiratory System in Never-smoking Patients With SilicosisCompletedNCT01725971
8Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
9Comprehensive Risk Assessment of People With Silicosis: A Population-based StudyRecruitingNCT02794701

Search NIH Clinical Center for Silicosis


Cochrane evidence based reviews: silicosis

Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

35
Lung, Bone, Lymph node, Bone marrow, Testes, Neutrophil, T cells

Animal Models for Silicosis or affiliated genes

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MGI Mouse Phenotypes related to Silicosis:

40 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1ACE, FAS, FASLG, NLRP3, SCGB1A1, TGFB1
2MP:00053709.1ACE, FAS, FASLG, NLRP3, TGFB1, TNF
3MP:00053888.9FAS, FASLG, SCGB1A1, SFTPD, TGFB1, TNF
4MP:00053898.8ACE, FAS, FASLG, IL1RN, NLRP3, TGFB1
5MP:00107718.7FAS, FASLG, IL1A, IL1B, IL1RN, NLRP3
6MP:00053858.6ACE, FAS, FASLG, IL1A, IL1B, IL1RN
7MP:00020068.6ACE, FAS, FASLG, IL1A, IL1B, SCGB1A1
8MP:00053908.5DSG1, FAS, FASLG, IL1B, IL1RN, NLRP3
9MP:00053977.4ACE, FAS, FASLG, IL1A, IL1B, IL1RN
10MP:00107687.3ACE, FAS, FASLG, IL1B, IL1RN, NLRP3
11MP:00053767.1ACE, FAS, FASLG, IL1A, IL1B, IL1RN
12MP:00053876.4ACE, CCL2, FAS, FASLG, IL1A, IL1B

Publications for Silicosis

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Articles related to Silicosis:

(show top 50)    (show all 640)
idTitleAuthorsYear
1
A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy. (27516887)
2016
2
Effects of bone marrow-derived mesenchymal stem cells on the autophagic activity of alveolar macrophages in a rat model of silicosis. (27284351)
2016
3
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. (26977968)
2016
4
Bronchoalveolar Lavage Fluid microRNA-146a: A Biomarker of Disease Severity and Pulmonary Function in Patients With Silicosis. (27158964)
2016
5
Case of accelerated silicosis in a sandblaster. (25567156)
2015
6
Pulmonary Silicosis Presents with Pleural Effusion. (26435716)
2015
7
From the 1930 International Johannesburg conference on silicosis, to "tables" of occupational diseases, France, 2000 onward: A comparative reading. (26509754)
2015
8
From silicosis to silica hazards: An experiment in medicine, history, and the social sciences. (26358619)
2015
9
Joint effects of smoking and silicosis on diseases to the lungs. (25105409)
2014
10
0397a88Serum heme oxygenase-1 level in silicosis patients and stone mortar and pestle production workers. (25018384)
2014
11
Eggshell Calcification of Lymph Nodes in Silicosis. (24983757)
2014
12
Erasmus syndrome: silicosis and systemic sclerosis. (24051915)
2013
13
Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. (21346639)
2011
14
Silicosis among agate workers at Shakarpur: An analysis of clinic-based data. (21139719)
2010
15
Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners. (19882740)
2009
16
Effect of silicosis alveolar macrophages on expression of c-myc in human embryo lung fibroblast in vitro]. (19358757)
2008
17
The value of high resolution computed tomography in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to radiography. (18667790)
2008
18
Surveillance for early silicosis in high altitude miners using pulse oximetry. (18686718)
2008
19
Changes of Clara cell protein and surfactant protein-D in serum of patients with silicosis]. (17374182)
2007
20
Dysregulation of Fas and related molecules in silicosis patients]. (15773295)
2005
21
Progressive massive fibrosis secondary to pulmonary silicosis appearance on F-18 fluorodeoxyglucose PET/CT. (15483503)
2004
22
Silicosis and smoking strongly increase lung cancer risk in silica-exposed workers. (15295901)
2004
23
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. (14514471)
2003
24
Silicosis in 76 men: qualitative and quantitative CT evaluation--clinical-radiologic correlation study. (12954899)
2003
25
The long and winding road from silica exposure to silicosis and other health effects. (12598660)
2003
26
Polymorphisms in the tumor necrosis factor-alpha gene promoter may predispose to severe silicosis in black South African miners. (11874815)
2002
27
The histogenesis of experimental silicosis. I--Methods for the histological evaluation of experimentally induced dust lesions. (2). 1960. (11899939)
2001
28
Silicosis and tuberculosis among South African goldminers--an overview of recent studies and current issues. (11544967)
2001
29
Accelerated silicosis in workers exposed to agate dust in Guangzhou, China. (11439400)
2001
30
IgG subclass responses in experimental silicosis. (11570675)
2001
31
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis. (10905501)
2000
32
Centennial photo page. Silicosis and a few of the other pneumoconiosies: observations on certain aspects of the problem, with emphasis on the role of the radiologist. 1958. (10915663)
2000
33
Pemphigus foliaceus associated with silicosis. (10951170)
2000
34
Mixed dust fibrosis and tuberculosis in comparison with silicosis and macular pneumoconiosis. (10642415)
2000
35
Pemphigus vulgaris associated with silicosis. (9693188)
1998
36
Relationship between serum total sialic acid and C-reactive protein in silicosis. (9562656)
1997
37
Elevated soluble Fas/APO-1 (CD95) levels in silicosis patients without clinical symptoms of autoimmune diseases or malignant tumours. (9367417)
1997
38
Photosensitivity and autoantibodies to Sm, Ro, and La in a patient with silicosis. (8876307)
1996
39
Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: studies of transforming growth factor beta expression. (8621163)
1996
40
Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography. (8800444)
1996
41
Silicosis in Brazilian pit diggers: relationship between dust exposure and radiologic findings. (7747743)
1995
42
Silicosis and pulmonary tuberculosis in stone-grinding factories in Saraburi, Thailand. (8868010)
1995
43
The epidemiology of tuberculosis in gold miners with silicosis. (7952577)
1994
44
Silicosis surveillance--Michigan, New Jersey, Ohio, and Wisconsin, 1987-1990. (8232180)
1993
45
Silicosis following employment in the manufacture of silica flour and industrial sand. (8366396)
1993
46
Does long-term concrete work cause silicosis? (1604279)
1992
47
Effect of prednisolone treatment in chronic silicosis. (2008993)
1991
48
Silicosis due to inhalation of domestic cleaning powder. (1681390)
1991
49
ESR spin trapping and cytotoxicity investigations of freshly fractured quartz: mechanism of acute silicosis. (2167264)
1990
50
Berylliosis and silicosis. (14841360)
1951

Variations for Silicosis

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Expression for genes affiliated with Silicosis

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Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show all 48)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL1A, IL1B
29.7FAS, FASLG, TNF
39.5IL1A, IL1B, TNF
49.5IL1A, IL1B, TNF
5
Show member pathways
9.4CXCL8, FASLG, TNF
6
Show member pathways
9.4FAS, FASLG, IL1A, TNF
79.4IL1B, TGFB1, TNF
8
Show member pathways
9.3CXCL8, IL1A, IL1B
99.3FAS, FASLG, IL1B, TNF
109.3CXCL8, IL1B, TNF
119.3CXCL8, IL1B, TNF
129.3FASLG, IL1A, IL1B, TNF
139.2FAS, FASLG, TGFB1, TNF
149.2FAS, FASLG, TGFB1, TNF
15
Show member pathways
9.2FAS, FASLG, TGFB1, TNF
169.2CCL2, IL1B, TNF
179.2CCL2, IL1B, TNF
189.1IL1A, IL1B, TGFB1, TNF
19
Show member pathways
9.1IL1A, IL1B, TGFB1, TNF
209.1IL1A, IL1B, TGFB1, TNF
219.1IL1A, IL1B, TGFB1, TNF
22
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
23
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
24
Show member pathways
9.0CXCL8, IL1A, IL1B, TNF
25
Show member pathways
9.0CXCL8, IL1A, IL1B, TNF
268.9CCL2, FAS, IL1B, TNF
278.9CXCL8, IL1A, IL1B, TGFB1
288.8CXCL8, IL1B, TGFB1, TNF
29
Show member pathways
8.8FAS, IL1A, IL1B, TGFB1, TNF
308.7CXCL8, IL1A, IL1B, IL1RN, TNF
318.6FAS, FASLG, IL1A, IL1B, TGFB1, TNF
32
Show member pathways
8.6FAS, FASLG, IL1A, IL1B, TGFB1, TNF
338.5CXCL8, IL1A, IL1B, NLRP3, TNF
348.4CCL2, FAS, FASLG, IL1B, IL1RN, TNF
35
Show member pathways
8.3CCL2, CXCL8, IL1A, IL1B, TGFB1
368.2CCL2, CXCL8, IL1B, TGFB1, TNF
37
Show member pathways
8.2CXCL8, IL1A, IL1B, IL1RN, NLRP3, TNF
38
Show member pathways
8.2CCL2, CXCL8, IL1B, NLRP3, TNF
398.1CCL2, CXCL8, FASLG, IL1A, IL1B, TNF
407.9CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
417.9CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
427.9CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
43
Show member pathways
7.9CXCL8, FAS, FASLG, IL1B, SFTPD, TNF
44
Show member pathways
7.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
45
Show member pathways
7.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
46
Show member pathways
7.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
47
Show member pathways
7.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
48
Show member pathways
7.2ACE, CCL2, CXCL8, FAS, FASLG, IL1B

GO Terms for genes affiliated with Silicosis

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Cellular components related to Silicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.7FAS, IL1B, SCGB1A1, TGFB1
2external side of plasma membraneGO:00098979.3ACE, FAS, FASLG, TNF
3extracellular spaceGO:00056155.5ACE, CCL2, CXCL8, FAS, FASLG, IL1A
4extracellular regionGO:00055765.0ACE, CCL2, CXCL8, FAS, FASLG, IL1A

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.8FAS, FASLG
2fever generationGO:000166010.5IL1A, IL1B
3positive regulation of monocyte chemotactic protein-1 productionGO:007163910.5IL1A, IL1B
4connective tissue replacement involved in inflammatory response wound healingGO:000224810.5IL1A, TGFB1
5positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IL1B, TNF
6sequestering of triglycerideGO:003073010.5IL1B, TNF
7chronic inflammatory response to antigenic stimulusGO:000243910.5IL1B, TNF
8regulation of establishment of endothelial barrierGO:190314010.5IL1B, TNF
9ectopic germ cell programmed cell deathGO:003523410.5IL1A, IL1B
10positive regulation of chemokine biosynthetic processGO:004508010.5IL1B, TNF
11positive regulation of mononuclear cell migrationGO:007167710.5TGFB1, TNF
12positive regulation of heterotypic cell-cell adhesionGO:003411610.4IL1B, TNF
13response to ozoneGO:001019310.4IL1B, SCGB1A1
14positive regulation of fever generationGO:003162210.4IL1B, TNF
15necroptotic signaling pathwayGO:009752710.4FAS, FASLG, TNF
16interleukin-1 beta productionGO:003261110.3IL1B, NLRP3
17mononuclear cell proliferationGO:003294310.3ACE, TGFB1
18extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.1FAS, IL1A, IL1B
19negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.1IL1A, IL1B, TNF
20positive regulation of JNK cascadeGO:004633010.1IL1A, IL1B, TNF
21extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.1FAS, FASLG, TNF
22positive regulation of cell divisionGO:005178110.0IL1A, IL1B, TGFB1
23positive regulation of interleukin-6 productionGO:003275510.0IL1A, IL1B, TNF
24cellular response to mechanical stimulusGO:007126010.0FAS, IL1B, TGFB1
25extrinsic apoptotic signaling pathwayGO:00971919.9FAS, FASLG, TGFB1, TNF
26apoptotic signaling pathwayGO:00971909.9FAS, FASLG, TNF
27maternal process involved in female pregnancyGO:00601359.9CCL2, DSG1, FAS
28positive regulation of vascular endothelial growth factor productionGO:00105759.9IL1A, IL1B, TGFB1
29positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.8FASLG, IL1A, IL1B, TNF
30response to progesteroneGO:00325709.7CCL2, DSG1, TGFB1
31cellular response to interleukin-1GO:00713479.6CCL2, CXCL8, FAS
32activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.6FAS, FASLG, NLRP3, TNF
33neutrophil chemotaxisGO:00305939.5CCL2, CXCL8, IL1B
34negative regulation of T cell proliferationGO:00421309.5SCGB1A1, SFTPD, TGFB1
35positive regulation of NF-kappaB transcription factor activityGO:00510929.4IL1B, NLRP3, TGFB1, TNF
36protein kinase B signalingGO:00434919.4CCL2, IL1B, TGFB1, TNF
37lipopolysaccharide-mediated signaling pathwayGO:00316639.4CCL2, IL1B, TGFB1, TNF
38response to glucocorticoidGO:00513849.3CCL2, FAS, IL1RN, SCGB1A1, TNF
39positive regulation of phagocytosisGO:00507669.3IL1B, SFTPD, TNF
40cellular response to organic cyclic compoundGO:00714079.2CCL2, IL1B, TGFB1, TNF
41response to lipopolysaccharideGO:00324969.2CCL2, FAS, FASLG, IL1B, SCGB1A1
42immune responseGO:00069559.2CXCL8, FAS, FASLG, IL1A, IL1RN
43positive regulation of apoptotic processGO:00430659.1FAS, FASLG, IL1B, TGFB1, TNF
44cellular response to lipopolysaccharideGO:00712229.1CCL2, CXCL8, NLRP3, TNF
45MAPK cascadeGO:00001659.1CCL2, IL1B, TGFB1, TNF
46apoptotic processGO:00069159.0FAS, FASLG, IL1A, IL1B, NLRP3
47agingGO:00075688.9CCL2, FAS, IL1B, TGFB1
48signal transductionGO:00071657.7CCL2, CXCL8, FAS, FASLG, IL1B, NLRP3
49inflammatory responseGO:00069547.7CCL2, CXCL8, FAS, IL1A, IL1B, NLRP3

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:000514910.3IL1A, IL1B
2cytokine activityGO:00051257.9CCL2, FASLG, IL1A, IL1B, IL1RN, TGFB1

Sources for Silicosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet