MCID: SLC006
MIFTS: 53

Silicosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

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Aliases & Descriptions for Silicosis:

Name: Silicosis 33 11 46 13 48 37 66
Silicotuberculosis 11 66
Chronic Silicosis 46 66
Acute Silicosis 46 66
Pneumoconiosis Due to Silicates 11
 
Silicotic Fibrosis of Lung 11
Experimental Silicosis 46
Accelerated Silicosis 46
Silica Pneumoconiosis 11

Classifications:



External Ids:

Disease Ontology11 DOID:10325
ICD1028 J62, J62.8
ICD9CM30 502
MeSH37 D012829
NCIt43 C3369

Summaries for Silicosis

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NIH Rare Diseases:46 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. a cough, weight loss, and fatigue may also be present. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 12/17/2015

MalaCards based summary: Silicosis, also known as silicotuberculosis, is related to pneumoconiosis due to talc and pulmonary hypertension. An important gene associated with Silicosis is TNF (Tumor Necrosis Factor), and among its related pathways are Interleukin-1 processing and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include lung, bone and lymph node, and related mouse phenotypes are liver/biliary system and respiratory system.

Disease Ontology:11 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:69 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1pneumoconiosis due to talc31.5TGFB1, TNF
2pulmonary hypertension30.6IL1B, TNF
3lymphopenia30.2CXCL8, IL1B, TNF
4asthma27.1CXCL8, FAS, IL1A, IL1B, IL1RN, NLRP3
5asbestosis26.9CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
6thyroid malformation10.8IL1B, TNF
7hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.8IL1B, TNF
8baetz-greenwalt syndrome10.8IL1B, TNF
9diabetic cataract10.7IL1A, IL1B
10gastric cancer risk after h. pylori infection10.7IL1B, IL1RN
11corneal deposit10.7CXCL8, IL1B
12tarsal tunnel syndrome10.7CXCL8, IL1B
13basidiobolomycosis10.7CXCL8, TNF
14pediatric systemic lupus erythematosus10.7FAS, FASLG
15small intestine lymphoma10.7IL1A, TNF
16granulomatous gastritis10.7FAS, FASLG
17cartilage disease10.6IL1B, TNF
18non-secretory myeloma10.6IL1B, IL1RN, TNF
19maligant granulosa cell tumor of ovary10.6CXCL8, TNF
20keloids10.6IL1B, IL1RN, TNF
21parsonage turner syndrome10.6TGFB1, TNF
22senile cataract10.6IL1B, IL1RN, TNF
2312p12.1 microdeletion syndrome10.6FAS, FASLG, TNF
24desbuquois dysplasia10.6FAS, IL1A
25myopathy-growth delay-intellectual disability-hypospadias syndrome10.6TGFB1, TNF
26calpainopathy10.6FAS, TGFB1
27sternum lymphoma10.6IL1B, IL1RN, TNF
28rectosigmoid junction neoplasm10.6IL1A, IL1B, TNF
29epstein-barr virus hepatitis10.6IL1A, TNF
30mental retardation anophthalmia craniosynostosis10.5IL1A, IL1B, IL1RN
31peri-anal fistula10.5IL1A, IL1B, IL1RN
32skin disease10.5CXCL8, IL1B, TNF
33benign lymphoepithelial lesion of salivary gland10.5IL1A, IL1B, TNF
34amyotrophic lateral sclerosis type 410.5CXCL8, IL1B, TNF
35paraphimosis10.5CXCL8, IL1B, TNF
36qualitative platelet defect10.5CXCL8, IL1B, TNF
37paraneoplastic polyneuropathy10.5CXCL8, IL1B, TNF
38benign breast adenomyoepithelioma10.5FAS, FASLG, IL1B
39inner ear cancer10.5CXCL8, IL1B, TNF
40anaerobic meningitis10.5IL1A, IL1B, IL1RN
41kidney angiomyolipoma10.5CXCL8, IL1B, TNF
42contact blepharoconjunctivitis10.5CXCL8, IL1B
43hypothyroidism10.5IL1B, TNF
44cervix erosion10.5CXCL8, IL1B, TNF
45histiocytoid hemangioma10.5IL1A, IL1B, IL1RN
46duodenum cancer10.5FAS, TNF
47intestinal variant cervical mucinous adenocarcinoma10.5CXCL8, IL1B, TNF
48bacteriuria10.5CXCL8, IL1B, TNF
49amelogenesis imperfecta10.5CXCL8, IL1B, TNF
50mononeuritis of lower limb10.5CXCL8, IL1B, TNF

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


AnthracosisProstatic Hypertrophy
Respiratory FailureHeart Disease
Postinflammatory Pulmonary FibrosisBronchitis

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Symptoms for Silicosis

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Drugs & Therapeutics for Silicosis

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Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RifapentinePhase 32961379-65-56323497
Synonyms:
(2R,16S,17R,18R,19R,20S,21S,22S,23S)-8-{[(4-CYCLOPENTYLPIPERAZIN-1-YL)IMINO]METHYL}-5,6,9,17,19-PENTAHYDROXY-23-METHOXY-2,4,12,16,18,20,22-HEPTAMETHYL-1,11-DIOXO-1,2-DIHYDRO-2,7-(EPOXYPENTADECA[1,11,13]TRIENOIMINO)NAPHTHO[2,1-B]FURAN-21-YL ACETATE
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV
3-(N-(4-Cyclopentyl-1-piperazinyl)formimidoyl)rifamycin
3-[N-(4-Cyclopentyl-1-piperazinyl)formimidoyl]rifamycin
61379-65-5
71950-35-1
Ambap127923-87-9
Antibiotic DL 473IT
BIDD:GT0669
C08059
C47H64N4O12
CHEBI:45304
CHEMBL1660
CID6323497
CID6434610
CID6835847
CID9919168
CPD000466332
CPD001906779
Cyclopentyl rifampin
Cyclopentylrifampicin
D00879
DB01201
DL 473
DL 473-IT
DL-4-73
DL-473
DL473
DRG-0283
 
EINECS 262-743-9
HMS2051D16
KTC 1
LS-143825
M000473
MDL 473
MDL-473
MDL473
MLS000759441
MLS001424209
NCGC00167431-01
Priftin
Priftin (TN)
Priftin (tn)
Priftin, Cyclopentylrifampicin, Rifapentine
R 77-3
R-773
RIFAPENTINE
RPE
RPT
Rifamycin AF/ACPP
Rifapentin
Rifapentina
Rifapentina [Spanish]
Rifapentine (USAN/INN)
Rifapentine [USAN:BAN:INN]
Rifapentinum
Rifapentinum [Latin]
S1760_Selleck
SAM001246620
SAM002589953
SMR000466332
UNII-XJM390A33U
2
RifampicinPhase 332813292-46-15458213, 5381226
Synonyms:
1-b]furan-21-yl acetate
13292-46-1
3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin sv
3-(4-Methylpiperazinyliminomethyl)-rifamycin SV
3-(4-Methylpiperazinyliminomethyl)rifamycin SV
3-([(4-Methyl-1-piperazinyl)imino]methyl)rifamycin SV
3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV
3-[[(4-Methyl-1-piperazinyl)imino]-methyl]rifamycin
46713_FLUKA
46713_RIEDEL
62534-43-4
8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
8-(4-Methylpiperazinyliminomethyl) rifamycin SV
8-[[(4-Methyl-1-piperazinyl)imino[methyl]rifamycin
8-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin sv
8-[[(4-Methylpiperazinyl)imino]methyl]rifamycin sv
83907_FLUKA
83907_SIGMA
8CI)
AZT + Rifampin
Abrifam
Archidyn
Arficin
Arzide
BA-41166E
BIDD:PXR0014
BPBio1_000561
BSPBio_000509
Ba 41166
Ba 41166/E
Benemicin
Benemycin
Bio-0621
C06688
C43H58N4O12
CAS-13292-46-1
CCRIS 551
CHEBI:28077
CHEBI:455936
CHEMBL180
CID5381226
CID5388984
CID5458213
CID5702112
CID6604339
CID6708473
CID6842115
CID6912767
CID6913622
CPD001906767
D00211
DB01045
DRG-0109
Dione 21-acetate
Dipicin
DivK1c_000550
Doloresum
EINECS 236-312-0
Eremfat
Famcin
Fenampicin
HMS1569J11
HMS1920P08
HMS2089F12
HMS2092G09
HMS501L12
HSDB 3181
KBio1_000550
KBio2_000919
KBio2_003487
KBio2_006055
KBio3_003018
KBioGR_001780
KBioSS_000919
L-5103
L-5103 Lepetit
LS-7689
MLS000028552
MLS001148237
MLS001333745
MolPort-000-767-051
MolPort-002-513-586
MolPort-003-666-281
MolPort-006-395-891
NCGC00016699-01
NCGC00017365-01
NCGC00018178-01
NCGC00022678-03
NCGC00022678-04
NCGC00022678-05
NCGC00160500-01
 
NCI60_000309
NINDS_000550
NSC 113926
NSC-113926
NSC113926
Piperine & Rifampicin
Prestwick0_000525
Prestwick1_000525
Prestwick2_000525
Prestwick3_000525
Prestwick_833
R-Cin
R/AMP
R0079
R3501_SIAL
R3501_SIGMA
R5777_SIGMA
R7382_SIGMA
RAMP
RFP
RMP
Ramp
Reserpine & Rifampicin
Rf
Rfamipicin
Rifa
Rifadin
Rifadin (TN)
Rifadin I.V
Rifadin I.V.
Rifadin IV
Rifadin Iv
Rifadin, Rimactane, Rifampicin, Rifampin
Rifadine
Rifagen
Rifaldazin
Rifaldazine
Rifaldin
Rifam
Rifamicin AMP
Rifamor
Rifampicin
Rifampicin & EEP
Rifampicin & Propolis
Rifampicin (JP15/INN)
Rifampicin SV
Rifampicin [INN:BAN:JAN]
Rifampicina
Rifampicina [INN-Spanish]
Rifampicine
Rifampicine [French]
Rifampicinum
Rifampicinum [INN-Latin]
Rifampin
Rifampin (USP)
Rifampin [USAN]
Rifamsolin
Rifamycin
Rifamycin AMP
Rifamycin Amp
Rifaprodin
Rifcin
Rifinah
Rifobac
Rifoldin
Rifoldine
Riforal
Rimactan
Rimactane
Rimactane (TN)
Rimactazid
Rimactin
Rimactizid
Rimazid
Rimycin
Rofact
S1764_Selleck
SAM002264646
SMR000058322
SMR000653525
SPBio_002430
SPECTRUM1500529
STK080143
Sinerdol
Spectrum3_001837
Spectrum4_001250
Spectrum5_002018
Spectrum_000439
TNP00313
Tubocin
UNII-VJT6J7R4TR
WLN: V1 WQ A&1 E&1 E1UN- AT6N DNTJ D1
nchembio884-comp4
rifampin
3
IsoniazidPhase 314654-85-33767
Synonyms:
37271-10-6
4-pyridinecarbohydrazide
41466-07-3
5015 R.P
5015 R.P.
5015 RP
54-85-3
62229-51-0
7640-37-1
AB00052025
AC1L1GNZ
AC1Q54UP
AC1Q54UQ
AI3-23936
AKOS000119062
AZT + Isoniazid
Abdizide
Andrazide
Anidrasona
Antimicina
Antituberkulosum
Armacide
Armazid
Armazide
Atcotibine
Azuren
BB_SC-6246
BIDD:GT0140
BP 5015
BPBio1_000025
BPBio1_001322
BSPBio_000021
BSPBio_002204
Bacillin
Biomol-NT_000288
C07054
C6H7N3O
CAS-54-85-3
CCRIS 351
CHEBI:6030
CHEMBL64
CID3767
CPD000059082
Cedin
Cedin (Aerosol)
Cemidon
Chemiazid
Chemidon
Continazine
Cortinazine
Cotinazin
Cotinizin
D00346
D007538
DB00951
Defonin
Dibutin
Diforin
Dinacrin
Ditubin
DivK1c_000070
Dow-Isoniazid
EINECS 200-214-6
Ebidene
Eralon
Ertuban
Eutizon
Evalon
FRS-3
FSR 3
FSR-3
Fetefu
Fimalene
GINK
HIA
HMS1568B03
HMS1920H09
HMS2089I16
HMS2091N19
HMS500D12
HSDB 1647
Hid rasonil
Hidranizil
Hidrasonil
Hidrulta
Hidrun
Hycozid
Hydra
Hydrazid
Hydrazide
Hyozid
Hyzyd
I.A.I
I.A.I.
I0138
I14-9731
I3377_FLUKA
I3377_SIGMA
IDI1_000070
INH
INHd20
Ido-tebin
Idrazil
In-73
Inah
Inh-Burgthal
Inizid
Iscotin
Isidrina
Ismazide
Isobicina
Isocid
Isocidene
Isocotin
Isohydrazide
Isokin
Isolyn
Isonerit
Isonex
Isoniacid
Isoniazid
Isoniazid & EEP
Isoniazid & Propolis
Isoniazid SA
Isoniazida
Isoniazide
Isoniazidum
Isonicazide
Isonicid
Isonico
Isonicotan
Isonicotil
Isonicotinhydrazid
Isonicotinic acid hydrazide
Isonicotinic hydrazide
Isonicotinohydrazide
Isonicotinoyl hydrazide
Isonicotinoylhydrazide
Isonicotinsaeurehydrazid
Isonicotinyl hydrazide
Isonicotinyl hydrazine
Isonicotinylhydrazine
Isonide
Isonidrin
Isonikazid
Isonilex
Isonin
Isonindon
Isonirit
Isoniton
Isonizida
Isonizide
Isopyrin
 
Isotamine
Isotebe
Isotebezid
Isotinyl
Isozid
Isozide
Isozyd
KBio1_000070
KBio2_001333
KBio2_003901
KBio2_006469
KBio3_001424
KBioGR_000423
KBioSS_001333
L 1945
LANIZID
LS-205
Laniazid
Laniazid (TN)
Laniozid
MLS000069444
MLS001055327
MolPort-000-141-557
Mybasan
NCGC00016244-01
NCGC00016244-02
NCGC00022648-03
NCGC00022648-04
NCGC00022648-05
NCGC00022648-06
NINDS_000070
NSC 9659
NSC9659
Neo-Tizide
Neoteben
Neoxin
Neumandin
Nevin
Niadrin
Nicazide
Nicetal
Nicizina
Niconyl
Nicotibina
Nicotibine
Nicotisan
Nicozide
Nidaton
Nidrazid
Nikozid
Niplen
Nitadon
Niteban
Nitebannsc 9659
Nydrazid
Nyscozid
Oprea1_396155
Pelazid
Percin
Phthisen
Preparation 6424
Prestwick0_000161
Prestwick1_000161
Prestwick2_000161
Prestwick3_000161
Prestwick_578
Pycazide
Pyreazid
Pyricidin
Pyridicin
Pyridine-4-carboxylic acid hydrazide
Pyrizidin
RP 5015
RP-5015
RU-EF-Tb
RY-EF-Tb
Raumanon
Razide
Retozide
Rifamate
Rimicid
Rimifon
Rimiphone
Rimitsid
Robiselin
Robisellin
Roxifen
S1937_Selleck
SAM002554904
SMR000059082
SPBio_000094
SPBio_001942
SPECTRUM1500355
STK086288
Sanohidrazina
Sauterazid
Sauterzid
Spectrum2_000107
Spectrum3_000472
Spectrum4_000022
Spectrum5_000876
Spectrum_000853
Stanozide
TB-Phlogin
TB-Razide
TB-Vis
Tebecid
Tebenic
Tebexin
Tebilon
Tebos
Teebaconin
Tekazin
Tibazide
Tibemid
Tibiazide
Tibinide
Tibison
Tibivis
Tibizide
Tibusan
Tisin
Tisiodrazida
Tizide
Tubazid
Tubazide
Tubeco
Tubecotubercid
Tuberian
Tubicon
Tubilysin
Tubizid
Tubomel
Tyvid
UNII-V83O1VOZ8L
Unicocyde
Unicozyde
Usaf cb-2
Vazadrine
Vederon
WLN: T6NJ DVMZ
ZINC00001590
Zidafimia
Zinadon
Zonazide
bacillen
bp 5 015
isoco tin
isoniazid
isozid e
nchembio884-comp3
nidra zid
rimif on
tebemid
tubercid

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis PreventionRecruitingNCT02430259Phase 3
2Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat SilicosisCompletedNCT01977131Phase 1, Phase 2
3Safety of Stem Cells Intrabronchial Instillation for SilicosisCompletedNCT01239862Phase 1
4A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem CellsRecruitingNCT02668068Phase 1
5Oscillation Mechanics of the Respiratory System in Never-smoking Patients With SilicosisCompletedNCT01725971
6Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
7Comprehensive Risk Assessment of People With Silicosis: A Population-based StudyRecruitingNCT02794701
8Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone)Not yet recruitingNCT01338064
9DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone)Not yet recruitingNCT01329003

Search NIH Clinical Center for Silicosis


Cochrane evidence based reviews: silicosis

Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

34
Lung, Bone, Lymph node, Bone marrow, Testes, Neutrophil, T cells

Animal Models for Silicosis or affiliated genes

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MGI Mouse Phenotypes related to Silicosis:

39 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.2ACE, FAS, FASLG, NLRP3, TGFB1, TNF
2MP:00053888.6FAS, FASLG, SCGB1A1, SFTPD, TGFB1, TNF
3MP:00053898.2ACE, FAS, FASLG, IL1RN, NLRP3, TGFB1
4MP:00053678.2ACE, FAS, FASLG, NLRP3, SCGB1A1, TGFB1
5MP:00107718.1FAS, FASLG, IL1A, IL1B, IL1RN, NLRP3
6MP:00020068.1ACE, FAS, FASLG, IL1A, IL1B, SCGB1A1
7MP:00053908.0FAS, FASLG, IL1B, IL1RN, NLRP3, TGFB1
8MP:00053857.6ACE, FAS, FASLG, IL1A, IL1B, IL1RN
9MP:00053977.0ACE, FAS, FASLG, IL1A, IL1B, IL1RN
10MP:00107686.5ACE, FAS, FASLG, IL1B, IL1RN, NLRP3
11MP:00053876.1ACE, CCL2, FAS, FASLG, IL1A, IL1B
12MP:00053765.8ACE, FAS, FASLG, IL1A, IL1B, IL1RN

Publications for Silicosis

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Articles related to Silicosis:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy. (27516887)
2016
2
Effects of bone marrow-derived mesenchymal stem cells on the autophagic activity of alveolar macrophages in a rat model of silicosis. (27284351)
2016
3
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. (26977968)
2016
4
Bronchoalveolar Lavage Fluid microRNA-146a: A Biomarker of Disease Severity and Pulmonary Function in Patients With Silicosis. (27158964)
2016
5
Case of accelerated silicosis in a sandblaster. (25567156)
2015
6
Pulmonary Silicosis Presents with Pleural Effusion. (26435716)
2015
7
From the 1930 International Johannesburg conference on silicosis, to "tables" of occupational diseases, France, 2000 onward: A comparative reading. (26509754)
2015
8
From silicosis to silica hazards: An experiment in medicine, history, and the social sciences. (26358619)
2015
9
Joint effects of smoking and silicosis on diseases to the lungs. (25105409)
2014
10
0397a88Serum heme oxygenase-1 level in silicosis patients and stone mortar and pestle production workers. (25018384)
2014
11
Eggshell Calcification of Lymph Nodes in Silicosis. (24983757)
2014
12
Erasmus syndrome: silicosis and systemic sclerosis. (24051915)
2013
13
Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. (21346639)
2011
14
Silicosis among agate workers at Shakarpur: An analysis of clinic-based data. (21139719)
2010
15
Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners. (19882740)
2009
16
Effect of silicosis alveolar macrophages on expression of c-myc in human embryo lung fibroblast in vitro]. (19358757)
2008
17
The value of high resolution computed tomography in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to radiography. (18667790)
2008
18
Surveillance for early silicosis in high altitude miners using pulse oximetry. (18686718)
2008
19
Changes of Clara cell protein and surfactant protein-D in serum of patients with silicosis]. (17374182)
2007
20
Dysregulation of Fas and related molecules in silicosis patients]. (15773295)
2005
21
Progressive massive fibrosis secondary to pulmonary silicosis appearance on F-18 fluorodeoxyglucose PET/CT. (15483503)
2004
22
Silicosis and smoking strongly increase lung cancer risk in silica-exposed workers. (15295901)
2004
23
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. (14514471)
2003
24
Silicosis in 76 men: qualitative and quantitative CT evaluation--clinical-radiologic correlation study. (12954899)
2003
25
The long and winding road from silica exposure to silicosis and other health effects. (12598660)
2003
26
Polymorphisms in the tumor necrosis factor-alpha gene promoter may predispose to severe silicosis in black South African miners. (11874815)
2002
27
The histogenesis of experimental silicosis. I--Methods for the histological evaluation of experimentally induced dust lesions. (2). 1960. (11899939)
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28
Silicosis and tuberculosis among South African goldminers--an overview of recent studies and current issues. (11544967)
2001
29
Accelerated silicosis in workers exposed to agate dust in Guangzhou, China. (11439400)
2001
30
IgG subclass responses in experimental silicosis. (11570675)
2001
31
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis. (10905501)
2000
32
Centennial photo page. Silicosis and a few of the other pneumoconiosies: observations on certain aspects of the problem, with emphasis on the role of the radiologist. 1958. (10915663)
2000
33
Pemphigus foliaceus associated with silicosis. (10951170)
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34
Mixed dust fibrosis and tuberculosis in comparison with silicosis and macular pneumoconiosis. (10642415)
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35
Pemphigus vulgaris associated with silicosis. (9693188)
1998
36
Relationship between serum total sialic acid and C-reactive protein in silicosis. (9562656)
1997
37
Elevated soluble Fas/APO-1 (CD95) levels in silicosis patients without clinical symptoms of autoimmune diseases or malignant tumours. (9367417)
1997
38
Photosensitivity and autoantibodies to Sm, Ro, and La in a patient with silicosis. (8876307)
1996
39
Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: studies of transforming growth factor beta expression. (8621163)
1996
40
Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography. (8800444)
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41
Silicosis in Brazilian pit diggers: relationship between dust exposure and radiologic findings. (7747743)
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Silicosis and pulmonary tuberculosis in stone-grinding factories in Saraburi, Thailand. (8868010)
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The epidemiology of tuberculosis in gold miners with silicosis. (7952577)
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Silicosis surveillance--Michigan, New Jersey, Ohio, and Wisconsin, 1987-1990. (8232180)
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45
Silicosis following employment in the manufacture of silica flour and industrial sand. (8366396)
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46
Does long-term concrete work cause silicosis? (1604279)
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47
Effect of prednisolone treatment in chronic silicosis. (2008993)
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48
Silicosis due to inhalation of domestic cleaning powder. (1681390)
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ESR spin trapping and cytotoxicity investigations of freshly fractured quartz: mechanism of acute silicosis. (2167264)
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Berylliosis and silicosis. (14841360)
1951

Variations for Silicosis

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Expression for genes affiliated with Silicosis

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Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL1A, IL1B
29.7IL1B, TGFB1, TNF
39.7IL1A, IL1B, TNF
49.7IL1A, IL1B, TNF
59.7FAS, FASLG, TNF
69.6CCL2, IL1B, TNF
7
Show member pathways
9.6CCL2, IL1B, TNF
89.6CCL2, IL1B, TNF
99.5CXCL8, IL1B, TNF
10
Show member pathways
9.5CXCL8, FASLG, TNF
11
Show member pathways
9.4CXCL8, IL1A, IL1B
129.4FAS, FASLG, IL1B, TNF
139.4IL1A, IL1B, TGFB1, TNF
14
Show member pathways
9.4IL1A, IL1B, TGFB1, TNF
159.4IL1A, IL1B, TGFB1, TNF
169.4IL1A, IL1B, TGFB1, TNF
179.4FAS, FASLG, TGFB1, TNF
18
Show member pathways
9.4FAS, FASLG, TGFB1, TNF
199.4FAS, FASLG, TGFB1, TNF
209.4FASLG, IL1A, IL1B, TNF
219.3CCL2, FAS, IL1B, TNF
229.3CXCL8, IL1B, TGFB1, TNF
23
Show member pathways
9.2CXCL8, IL1A, IL1B, TNF
24
Show member pathways
9.2CXCL8, IL1A, IL1B, TNF
259.2CXCL8, IL1A, IL1B, TGFB1
26
Show member pathways
9.1FAS, IL1A, IL1B, TGFB1, TNF
27
Show member pathways
9.1FAS, FASLG, IL1A, IL1B, TNF
28
Show member pathways
9.1FAS, FASLG, IL1A, IL1B, TNF
298.9CXCL8, IL1A, IL1B, NLRP3, TNF
308.8CCL2, CXCL8, IL1B, TGFB1, TNF
31
Show member pathways
8.8FAS, FASLG, IL1A, IL1B, TGFB1, TNF
328.8FAS, FASLG, IL1A, IL1B, TGFB1, TNF
33
Show member pathways
8.8FAS, FASLG, IL1A, TNF, TNFRSF6B
34
Show member pathways
8.8CCL2, CXCL8, IL1B, NLRP3, TNF
35
Show member pathways
8.8CCL2, CXCL8, IL1A, IL1B, TGFB1
368.5CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
378.5CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
388.5CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
398.5CCL2, CXCL8, FASLG, IL1A, IL1B, TNF
40
Show member pathways
8.4CXCL8, FAS, FASLG, IL1B, SFTPD, TNF
418.4CXCL8, IL1A, IL1B, IL1RN, TNF
42
Show member pathways
8.4CXCL8, FAS, FASLG, IL1A, IL1B, TGFB1
438.2CCL2, FAS, FASLG, IL1B, IL1RN, TNF
44
Show member pathways
8.0CXCL8, IL1A, IL1B, IL1RN, NLRP3, TNF
45
Show member pathways
7.9CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
46
Show member pathways
7.9CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
47
Show member pathways
7.9ACE, CCL2, CXCL8, FAS, FASLG, IL1B
48
Show member pathways
7.9CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
49
Show member pathways
7.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
50
Show member pathways
7.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B

GO Terms for genes affiliated with Silicosis

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Cellular components related to Silicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.6ACE, FAS, FASLG, TNF
2secretory granuleGO:00301419.6FAS, IL1B, SCGB1A1, TGFB1
3extracellular spaceGO:00056155.1ACE, CCL2, CXCL8, FAS, FASLG, IL1A
4extracellular regionGO:00055765.1ACE, CCL2, CXCL8, FAS, FASLG, IL1A

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.7IL1B, TNF
2sequestering of triglycerideGO:003073010.7IL1B, TNF
3chronic inflammatory response to antigenic stimulusGO:000243910.7IL1B, TNF
4regulation of establishment of endothelial barrierGO:190314010.7IL1B, TNF
5positive regulation of chemokine biosynthetic processGO:004508010.7IL1B, TNF
6positive regulation of mononuclear cell migrationGO:007167710.7TGFB1, TNF
7inflammatory cell apoptotic processGO:000692510.7FAS, FASLG
8fever generationGO:000166010.6IL1A, IL1B
9positive regulation of monocyte chemotactic protein-1 productionGO:007163910.6IL1A, IL1B
10connective tissue replacement involved in inflammatory response wound healingGO:000224810.6IL1A, TGFB1
11positive regulation of heterotypic cell-cell adhesionGO:003411610.6IL1B, TNF
12positive regulation of fever generationGO:003162210.6IL1B, TNF
13ectopic germ cell programmed cell deathGO:003523410.6IL1A, IL1B
14mononuclear cell proliferationGO:003294310.6ACE, TGFB1
15interleukin-1 beta productionGO:003261110.6IL1B, NLRP3
16obsolete transformed cell apoptotic processGO:000692710.5FAS, TNF
17necroptotic signaling pathwayGO:009752710.4FAS, FASLG, TNF
18positive regulation of cell divisionGO:005178110.2IL1A, IL1B, TGFB1
19negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.2IL1A, IL1B, TNF
20cellular response to mechanical stimulusGO:007126010.2FAS, IL1B, TGFB1
21positive regulation of JNK cascadeGO:004633010.2IL1A, IL1B, TNF
22extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.1FAS, IL1A, IL1B
23positive regulation of vascular endothelial growth factor productionGO:001057510.1IL1A, IL1B, TGFB1
24positive regulation of interleukin-6 productionGO:003275510.1IL1A, IL1B, TNF
25PERK-mediated unfolded protein responseGO:003649910.1CCL2, CXCL8
26response to ozoneGO:001019310.1IL1B, SCGB1A1
27extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.1FAS, FASLG, TNF
28extrinsic apoptotic signaling pathwayGO:009719110.0FAS, FASLG, TGFB1, TNF
29lipopolysaccharide-mediated signaling pathwayGO:003166310.0CCL2, IL1B, TGFB1, TNF
30protein kinase B signalingGO:00434919.9CCL2, IL1B, TGFB1, TNF
31positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.9FASLG, IL1A, IL1B, TNF
32neutrophil chemotaxisGO:00305939.9CCL2, CXCL8, IL1B
33cellular response to interleukin-1GO:00713479.8CCL2, CXCL8, FAS
34positive regulation of NF-kappaB transcription factor activityGO:00510929.8IL1B, NLRP3, TGFB1, TNF
35positive regulation of phagocytosisGO:00507669.8IL1B, SFTPD, TNF
36cellular response to organic cyclic compoundGO:00714079.8CCL2, IL1B, TGFB1, TNF
37activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.7FAS, FASLG, NLRP3, TNF
38MAPK cascadeGO:00001659.7CCL2, IL1B, TGFB1, TNF
39cellular response to lipopolysaccharideGO:00712229.5CCL2, CXCL8, NLRP3, TNF
40agingGO:00075689.5CCL2, FAS, IL1B, TGFB1
41regulation of cell proliferationGO:00421279.5FAS, TGFB1, TNF, TNFRSF6B
42negative regulation of T cell proliferationGO:00421309.5SCGB1A1, SFTPD, TGFB1
43apoptotic signaling pathwayGO:00971909.4FAS, FASLG, TNF, TNFRSF6B
44positive regulation of apoptotic processGO:00430659.4FAS, FASLG, IL1B, TGFB1, TNF
45response to glucocorticoidGO:00513848.7CCL2, FAS, IL1RN, SCGB1A1, TNF
46apoptotic processGO:00069158.7FAS, FASLG, IL1A, IL1B, NLRP3
47response to lipopolysaccharideGO:00324968.4CCL2, FAS, FASLG, IL1B, SCGB1A1, TNFRSF6B
48immune responseGO:00069557.9CXCL8, FAS, FASLG, IL1A, IL1RN, TNFRSF6B
49signal transductionGO:00071657.8CCL2, CXCL8, FAS, FASLG, IL1B, NLRP3
50inflammatory responseGO:00069547.8CCL2, CXCL8, FAS, IL1A, IL1B, NLRP3

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:000514910.3IL1A, IL1B
2cytokine activityGO:00051257.9CCL2, FASLG, IL1A, IL1B, IL1RN, TGFB1

Sources for Silicosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet