MCID: SLC006
MIFTS: 58

Silicosis malady

Respiratory diseases category

Summaries for Silicosis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 11/3/2010

MalaCards: Silicosis, also known as silicotuberculosis, is related to tuberculosis and pulmonary fibrosis. An important gene associated with Silicosis is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds cycloheximide and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and testes, and related mouse phenotypes are skeleton and tumorigenesis.

Disease Ontology:8 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:63 Silicosis, (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Aliases & Classifications for Silicosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

silicosis 8 42 10 44 60
silicotuberculosis 8 60
chronic silicosis 42 60
acute silicosis 42 60
pneumoconiosis due to other silica 8
pneumoconiosis due to silicates 8
pneumoconiosis due to silica 8
silicotic fibrosis of lung 8
silica pneumoconiosis nos 8
experimental silicosis 42
accelerated silicosis 42
silicates 8


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Disease Ontology8 DOID:10325
MeSH34 D012829
ICD9CM27 502
NCIt39 C3369

Related Diseases for Silicosis

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17GeneCards, 18GeneDecks
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Diseases related to Silicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.9IL12B, SFTPD, IFNGR1
2pulmonary fibrosis30.3SFTPD
3pemphigus30.1DSG3, DSG1
4systemic lupus erythematosus30.1FASLG, IL1RN, IL12B, IFNGR1, FAS
5sarcoidosis30.1IL12B, IL1A, IL1RN, SFTPD, IFNGR1, SCGB1A1
6osteoarthritis29.9IL12B, IL1A, ACRV1, IL1RN
7melanoma29.9DSG1, IL1A, EGR1, FAS, FASLG
8adenocarcinoma29.9CLEC3B, DSG3, EGR1, FASLG, FAS, TNFRSF6B
9hepatitis29.8FASLG
10arthritis29.8IL1A, IL1RN
11dermatitis29.8DSG1, DSG3, IL1A
12interstitial lung disease29.8SFTPD, IL1RN, IL1A
13dermatomyositis29.8IL1A, IL1RN, SFTPD
14idiopathic pulmonary fibrosis29.8FASLG, SCGB1A1, SFTPD, IL1RN, IL1A
15lymphopenia29.8FAS, FASLG, IL1RN
16aspergillosis29.8SFTPD
17lung cancer10.7
18pneumoconiosis10.5
19asbestosis10.5
20pulmonary tuberculosis10.3
21pneumothorax10.3
22bronchitis10.1
23anthracosis10.1
24berylliosis10.1
25connective tissue disease10.1
26lupus erythematosus10.1
27elephantiasis10.1
28synovitis10.1
29bagassosis10.0
30lymph node cancer10.0
31pancreatitis10.0
32pneumonia10.0
33inflammatory bowel disease10.0IL1RN
34allergic rhinitis10.0SCGB1A1
35periodontitis10.0IL1A
36rhinitis10.0SCGB1A1
37gingivitis10.0IL1A
38bronchiolitis obliterans10.0SCGB1A1
39sarcoma10.0DSG1
40chorioamnionitis10.0IL1RN
41measles10.0IL12B
42lichen planus10.0DSG3
43thrombocytopenia10.0IL1A
44leishmaniasis10.0IFNGR1
45myeloma10.0FAS, FASLG
46adenoma10.0IL11RA
47cervical cancer10.0IL1A
48pemphigus vegetans10.0DSG1
49influenza10.0SFTPD
50polymyalgia rheumatica10.0IL1RN

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Clinical Features for Silicosis

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Drugs & Therapeutics for Silicosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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32MalaCards
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MalaCards organs/tissues related to Silicosis:

32
Lung, Lymph node, Testes, Bone, T cells, Kidney, Skin, Pancreas, Liver, Smooth muscle, Brain, Eye

Animal Models for Silicosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Silicosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.3FASLG, FAS, IFNGR1
2MP:000200610.2IFNGR1, FASLG, SCGB1A1, IL12B
3MP:00053879.7IL1A, SFTPD, IFNGR1, TNFRSF18, FAS, FASLG
4MP:00053979.7FASLG, FAS, TNFRSF18, IFNGR1, SFTPD, EGR1
5MP:00053849.5IFNGR1, TNFRSF18, FAS, FASLG, EGR1, ZBTB32

Publications for Silicosis

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50PubMed
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Articles related to Silicosis:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
A stone miner with both silicosis and constrictive pericarditis: case report and review of the literature. (24314106)
2013
2
Survival following lung transplantation for silicosis and other occupational lung diseases. (22071439)
2012
3
Silicosis caused by chronic inhalation of snail shell powder. (22219621)
2012
4
Relationship between polymorphism of interleukin-8 and silicosis susceptibility]. (22214159)
2011
5
Prevalence of silicosis in a marble factory after exposure to quartz conglomerates. (21190766)
2011
6
Results of spirometry among individuals in a silicosis registry. (21124246)
2010
7
The value of high resolution computed tomography in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to radiography. (18667790)
2008
8
Polymorphisms of FAS and FASL genes and susceptibility of silicosis]. (18302883)
2008
9
National trends in silicosis mortality in the United States, 1981-2004. (18626906)
2008
10
An epidemic of silicosis among former denim sandblasters. (18579544)
2008
11
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population. (18666137)
2008
12
Type 2 immune response associated with silicosis is not instrumental in the development of the disease. (16997884)
2007
13
Basic pathogenetic mechanisms in silicosis: current understanding. (15699791)
2005
14
Silicosis and tuberculosis in Zambian miners. (16130967)
2005
15
Progressive massive fibrosis secondary to pulmonary silicosis appearance on F-18 fluorodeoxyglucose PET/CT. (15483503)
2004
16
Highway repair: a new silicosis threat. (15117715)
2004
17
Histopathological screening for silicosis in autopsy cases of the Umtata area of the Eastern Cape Province. (14587541)
2003
18
Initial experience on rifampin and pyrazinamide vs isoniazid in the treatment of latent tuberculosis infection among patients with silicosis in Hong Kong. (14665488)
2003
19
A case-control study of lung cancer in relation to silica exposure and silicosis in a rural area in Japan. (12062914)
2002
20
Silicosis in the twenty first century. (12409528)
2002
21
Exposure-response analysis and risk assessment for silica and silicosis mortality in a pooled analysis of six cohorts. (12409529)
2002
22
Silicosis compensation in Western Australian gold miners since the introduction of an occupational exposure standard for crystalline silica. (12406862)
2002
23
Cohort mortality study of North American industrial sand workers. II. Case-referent analysis of lung cancer and silicosis deaths. (11295143)
2001
24
Autoantibodies detectable in the sera of silicosis patients. The relationship between the anti-topoisomerase I antibody response and HLA-DQB1*0402 allele in Japanese silicosis patients. (11327387)
2001
25
Centennial photo page. Silicosis and a few of the other pneumoconiosies: observations on certain aspects of the problem, with emphasis on the role of the radiologist. 1958. (10915663)
2000
26
Silicosis and tuberculosis: a proposed radiographic classification of tuberculosis to accompany the ILO international classification of radiographs of pneumoconioses. (10926726)
2000
27
Silica, silicosis, and lung cancer: a response to a recent working group report. (10914339)
2000
28
Matrix metalloproteinases 2, 9, and 13, and tissue inhibitors of metalloproteinases 1 and 2 in experimental lung silicosis. (10508819)
1999
29
Quartz exposures and severe silicosis: a role for the hilar nodes. (9764097)
1998
30
Risks of silicosis in coalworkers exposed to unusual concentrations of respirable quartz. (9536164)
1998
31
Application and analysis of biochemical indices for the evaluation of antisilicosis treatment. Study on anti-silicosis therapy and its evaluation research group]. (10682587)
1998
32
The influence of silicosis on deteriorating lung function in gold miners. (9498949)
1998
33
Short course chemoprophylaxis with rifampicin, isoniazid and pyrazinamide for tuberculosis evaluated in gold miners with chronic silicosis: a double-blind placebo controlled trial. (8758107)
1996
34
Macrophage-lymphocyte cytokine interactions in silicosis. (8598152)
1996
35
Extrapulmonary silicosis in two water buffaloes. (7722011)
1995
36
Silicosis surveillance in Ontario: detection rates, modifying factors, and screening intervals. (8147398)
1994
37
Epidermal growth factor-like activity in bronchoalveolar lavage fluid in experimental silicosis. (7946405)
1994
38
Cor pulmonale and silicosis: a necropsy based case-control study. (8329320)
1993
39
Triple lung cancers in a patient with silicosis. (8390766)
1993
40
Altered patterns of lung lymphocyte accumulation in silicosis in cytokine-sufficient (C3H/HeN) and cytokine-deficient (C3H/HeJ-LPSd) mice. (8428530)
1993
41
Immunogenetic analysis of silicosis in Japan. (8093341)
1993
42
Does long-term concrete work cause silicosis? (1604279)
1992
43
Predictors of mortality in silicosis. (1615176)
1992
44
Screening of pulmonary hypertension in chronic obstructive pulmonary disease and silicosis by discriminant functions. (1563503)
1992
45
Reevaluation of silicosis and lung cancer in North Carolina dusty trades workers. (1415283)
1992
46
Pneumoconiosis (silicosis) in the confectionery industry. (2345825)
1990
47
Changes in lymphocyte function and lung histology during the development of asbestosis and silicosis in the mouse. (2587839)
1989
48
A patient with hereditary spherocytosis and silicosis who developed an IgA(lambda) monoclonal gammopathy. (3573411)
1987
49
Serum lysosomal enzyme activities in silicosis and asbestosis. (6840231)
1983
50
Surgical treatment of pulmonary tuberculosis associated with anthracosis and silicosis in coal miners. (13740008)
1961

Genetic Variations for Silicosis

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Expression for genes affiliated with Silicosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 51QIAGEN, 55SinoBiological
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Pathways related to Silicosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4FAS, FASLG
210.4FASLG, FAS
310.3DSG1, DSG3
410.3IL12B, FASLG, FAS
5
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10.3FASLG, FAS, TNFRSF6B
6
Apoptosis and survival Apoptotic TNF-family pathways
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10.3TNFRSF18, FAS, FASLG
710.3TNFRSF18, FASLG, EGR1
8
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10.3IL12B, IL11RA, TNFRSF18
9
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10.3IL12B, FASLG, FAS, IFNGR1
10
Apoptosis and survival Caspase cascade
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10.3IL1A, FASLG, FAS, TNFRSF6B
11
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10.2IL1A, IL1RN, EGR1, IFNGR1
12
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10.2TNFRSF6B, TNFRSF18, FAS, FASLG
13
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10.2FASLG, FAS, TNFRSF18, TNFRSF6B
14
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10.2IFNGR1, FAS, FASLG, IL12B, IL1A
15
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10.2IFNGR1, FAS, FASLG, IL12B, IL1A
16
Hide members
10.2IFNGR1, FAS, FASLG, EGR1, IGLV@
17
Immune response Bacterial infections in normal airways
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10.2IL1A, SFTPD, IFNGR1, FAS, FASLG, IL1RN
18
Hide members
10.0IFNGR1, TNFRSF6B, TNFRSF18, FAS, FASLG, IL11RA

Compounds for genes affiliated with Silicosis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Silicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8FASLG
2indomethacin44 59 28 1113.8EGR1
3endotoxin4410.8SCGB1A1, FASLG
42-chloroethyl ethyl sulfide4410.8IL1A, IL1RN
5prednisolone44 28 1112.7DSG3, SFTPD
6imiquimod44 28 59 1113.7IL1A, IL12B, FASLG
7(glc)44410.7FASLG, FAS
8tetracycline44 1111.7FAS, IL1A, SCGB1A1, FASLG
93-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4410.7FAS, IL1A, FASLG
10sulfasalazine44 28 49 1113.7IL1RN, IL1A, IL12B
11cellulose triacetate4410.7IL1A, IL1RN
12manganese superoxide4410.7FASLG, IL1RN, EGR1, IL1A
13rantes4410.7FASLG, IL12B, IL1A, FAS
14vitamin a44 11 2412.7FAS, IL1A
15morphine44 49 28 1113.7FAS, IL1RN, FASLG, IL1A
16gp 1304410.7IL11RA, SCGB1A1, IFNGR1, FAS
17il 104410.7IL12B, IL1A, IL1RN
18hyaluronic acid44 2411.7IL1A, IL1RN, FASLG, SCGB1A1
19tgf beta14410.7EGR1, FASLG, IL1RN, FAS
20agarose4410.7IL1RN, FASLG, FAS, SFTPD
21epinephrine44 11 2412.6EGR1, FAS, FASLG, IL1RN, IL1A
22ionomycin4410.6FASLG, FAS, IL1A, EGR1
23calyculin a44 59 1112.6FAS, EGR1, FASLG
24pentoxifylline44 1111.6IL12B, IL1RN, IL1A
25paclitaxel44 49 1112.6FAS, FASLG, EGR1, IL1A, IL12B
26serine4410.6IL1RN, IL1A, DSG1, DSG3
27atpo44 2811.6FASLG, FAS
28sb 20358044 5911.6IL1RN, EGR1, FASLG, IL12B, FAS, IL1A
29ivig4410.6IL1A, IL1RN, DSG1, DSG3, FASLG, FAS
30ag 14784410.6FASLG, FAS, EGR1
31cyclosporin a44 28 5912.6EGR1, IL1A, IL1RN, FASLG, FAS
32iron44 2411.6FASLG, IL1RN, SCGB1A1, IFNGR1, EGR1
33toxin a4410.5DSG1, DSG3
34ribonucleic acid4410.5EGR1, IL1RN, IL1A, FAS
35ascorbic acid44 2411.5IL1RN, IL1A, FASLG, FAS
36dexamethasone44 49 28 1113.5FAS, IL1A, IL1RN, SFTPD, CLEC3B, EGR1
37thymidine44 2411.5SFTPD, FAS, FASLG, IL1A, EGR1
38nitric oxide44 11 2412.5IL1A, IL1RN, IL12B, EGR1, SCGB1A1, FASLG
39heparin44 28 11 2413.5IL1A, IL1RN, FAS, CLEC3B, FASLG
40phosphatidylinositol4410.5EGR1, IL1RN, SCGB1A1, IL12B, FASLG, FAS
41oxygen44 2411.5EGR1, IFNGR1, CLEC3B, IL1RN, FAS, SFTPD
42anisomycin44 1111.5EGR1, FASLG, FAS
43h2o24410.4IL1RN, FASLG
44retinoic acid44 2411.3FASLG, IL1A, IL1RN, DSG1, EGR1, FAS
45progesterone44 59 28 11 2414.3SCGB1A1, EGR1, IL1RN, FASLG, IL1A
46polysaccharide4410.3SFTPD, FAS, CLEC3B, FASLG
47calcium44 49 11 2413.3IL1RN, CLEC3B, DSG1, IL12B, DSG3, EGR1
48acetylcholine44 49 28 11 2414.2IL1A, EGR1, DSG3, DSG1
49vitamin d4410.2IL1A, IL1RN, IL12B, FAS
50testosterone44 59 11 2412.9IL1RN, FASLG, IL1A, FAS, EGR1

GO Terms for genes affiliated with Silicosis

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16Gene Ontology
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Cellular components related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0TNFRSF18, FAS, FASLG, CLEC3B, IL1A, LRG1
2extracellular spaceGO:0056159.6LRG1, SFTPD, TNFRSF6B, FASLG, SCGB1A1, CLEC3B

Biological processes related to Silicosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.6FASLG, FAS
2cellular response to hyperoxiaGO:07145510.5EGR1, FAS
3response to glucocorticoid stimulusGO:05138410.4FAS, SCGB1A1, IL1RN
4apoptotic processGO:00691510.3TNFRSF6B, FAS, FASLG, DSG3, DSG1, IL1A
5regulation of cytokine productionGO:00181710.2ZBTB32, SFTPD
6negative regulation of apoptotic processGO:04306610.2TNFRSF6B, TNFRSF18, FAS, EGR1, IL1RN
7signal transductionGO:00716510.1TNFRSF18, FAS, FASLG, SCGB1A1, IL11RA, IFNGR1
8regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.1FASLG, FAS

Molecular functions related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.4IL1A, IL1RN

Products for genes affiliated with Silicosis

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  • Antibodies
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Sources for Silicosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet