MCID: SLC006
MIFTS: 47

Silicosis malady

Rare diseases, Respiratory diseases categories

Aliases & Classifications for Silicosis

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Aliases & Descriptions for Silicosis:

Name: Silicosis 32 10 45 47 12 65 36
Pneumoconiosis Due to Silicates 10 65
Silicotuberculosis 10 65
Chronic Silicosis 45 65
Acute Silicosis 45 65
Pneumoconiosis Due to Other Silica 10
 
Pneumoconiosis Due to Silica 10
Silicotic Fibrosis of Lung 10
Silica Pneumoconiosis Nos 10
Experimental Silicosis 45
Accelerated Silicosis 45
Silicates 10


Classifications:



External Ids:

Disease Ontology10 DOID:10325
MeSH36 D012829
NCIt42 C3369
ICD9CM29 502

Summaries for Silicosis

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NIH Rare Diseases:45 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 11/3/2010

MalaCards based summary: Silicosis, also known as pneumoconiosis due to silicates, is related to pneumoconiosis and tuberculosis. An important gene associated with Silicosis is FASLG (Fas Ligand (TNF Superfamily, Member 6)), and among its related pathways are Interleukin-1 processing and Signal transduction_JNK pathway. Affiliated tissues include lung, bone and lymph node, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Disease Ontology:10 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:68 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1pneumoconiosis31.2CXCL8, TGFB1, TNF
2tuberculosis30.7CXCL8, IL1B, IL4, TGFB1, TNF
3pneumothorax30.5CXCL8, IL1B, SCGB1A1, SFTPD, TNF
4dermatitis30.2CXCL8, IL1B, TNF
5lymphoepithelioma-like carcinoma30.2IL1A, IL1B, TNF
6hepatitis30.1CXCL8, FAS, TNF
7scleroderma30.1IL4, TNF
8collagen disease29.8CXCL8, IL1B, IL4, TNF
9osteoporosis29.8IL1A, IL1B, IL1RN, TGFB1, TNF
10pneumonia29.8CXCL8, FAS, FASLG, IL1B, SCGB1A1, TGFB1
11lung cancer10.8
12asbestosis10.6
13pulmonary tuberculosis10.4
14anthracosis10.3
15meckel's diverticulitis10.3IL1B, TNF
16heavy chain deposition disease10.3FAS, FASLG
17stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.3IL1B, TNF
18fungal gastritis10.3FAS, FASLG
19systemic lupus erythematosus10.3
20interstitial lung disease10.3
21lupus erythematosus10.3
22t cell immunodeficiency primary10.3IL1RN, TNF
23developmental and speech delay due to sox5 deficiency10.3FAS, FASLG, TNF
24diabetic ketoacidosis10.2CXCL8, IL1B
25malignant sertoli-leydig cell tumor of ovary10.2CXCL8, TNF
26skin disease10.2IL1A, TNF
27gastric cancer risk after h. pylori infection10.2IL1B, IL1RN
28burns10.2FAS, TGFB1
29diabetic cataract10.2IL1A, IL1B
30peyronie's disease10.2FAS, IL1B, TNF
31calpainopathy10.2IL1B, TNF
32wild type abeta2m amyloidosis10.2CXCL8, FAS
33viral infectious disease10.2FAS, FASLG, TNF
34waardenburg syndrome type 410.2IL1B, IL1RN, TNF
35pyeloureteritis cystica10.2CXCL8, IL1A
36periarthritis10.2FAS, FASLG, IL1B
37fallopian tube cystadenofibroma10.2IL1B, IL1RN, TNF
38dawson disease10.2CXCL8, FAS, TNF
39echinostomiasis10.2CXCL8, SCGB1A1, TNF
40endocervicitis10.2IL1B, IL1RN, TNF
41kartagener syndrome10.2IL1B, IL1RN, TNF
42osmotic diarrhea10.2IL1B, IL1RN, TNF
43congenital nasal pyriform aperture stenosis with holoprosencephaly10.2ACE, TNF
44bullous retinoschisis10.2ACE, TNF
45plantar nerve lesion10.2CXCL8, IL1B, TNF
46pemphigus10.2
47berylliosis10.2
48bronchitis10.2
49cork-handlers' disease10.2
50connective tissue disease10.2

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Symptoms for Silicosis

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Drugs & Therapeutics for Silicosis

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Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RifapentineapprovedPhase 32461379-65-56323497
Synonyms:
(2R,16S,17R,18R,19R,20S,21S,22S,23S)-8-{[(4-CYCLOPENTYLPIPERAZIN-1-YL)IMINO]METHYL}-5,6,9,17,19-PENTAHYDROXY-23-METHOXY-2,4,12,16,18,20,22-HEPTAMETHYL-1,11-DIOXO-1,2-DIHYDRO-2,7-(EPOXYPENTADECA[1,11,13]TRIENOIMINO)NAPHTHO[2,1-B]FURAN-21-YL ACETATE
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV
3-(N-(4-Cyclopentyl-1-piperazinyl)formimidoyl)rifamycin
3-[N-(4-Cyclopentyl-1-piperazinyl)formimidoyl]rifamycin
61379-65-5
71950-35-1
Ambap127923-87-9
Antibiotic DL 473IT
BIDD:GT0669
C08059
C47H64N4O12
CHEBI:45304
CHEMBL1660
CID6323497
CID6434610
CID6835847
CID9919168
CPD000466332
CPD001906779
Cyclopentyl rifampin
Cyclopentylrifampicin
D00879
DB01201
DL 473
DL 473-IT
DL-4-73
DL-473
DL473
DRG-0283
 
EINECS 262-743-9
HMS2051D16
KTC 1
LS-143825
M000473
MDL 473
MDL-473
MDL473
MLS000759441
MLS001424209
NCGC00167431-01
Priftin
Priftin (TN)
Priftin (tn)
Priftin, Cyclopentylrifampicin, Rifapentine
R 77-3
R-773
RIFAPENTINE
RPE
RPT
Rifamycin AF/ACPP
Rifapentin
Rifapentina
Rifapentina [Spanish]
Rifapentine (USAN/INN)
Rifapentine [USAN:BAN:INN]
Rifapentinum
Rifapentinum [Latin]
S1760_Selleck
SAM001246620
SAM002589953
SMR000466332
UNII-XJM390A33U
2
RifampinapprovedPhase 329013292-46-15458213, 5381226
Synonyms:
1-b]furan-21-yl acetate
13292-46-1
3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin sv
3-(4-Methylpiperazinyliminomethyl)-rifamycin SV
3-(4-Methylpiperazinyliminomethyl)rifamycin SV
3-([(4-Methyl-1-piperazinyl)imino]methyl)rifamycin SV
3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV
3-[[(4-Methyl-1-piperazinyl)imino]-methyl]rifamycin
46713_FLUKA
46713_RIEDEL
62534-43-4
8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
8-(4-Methylpiperazinyliminomethyl) rifamycin SV
8-[[(4-Methyl-1-piperazinyl)imino[methyl]rifamycin
8-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin sv
8-[[(4-Methylpiperazinyl)imino]methyl]rifamycin sv
83907_FLUKA
83907_SIGMA
8CI)
AZT + Rifampin
Abrifam
Archidyn
Arficin
Arzide
BA-41166E
BIDD:PXR0014
BPBio1_000561
BSPBio_000509
Ba 41166
Ba 41166/E
Benemicin
Benemycin
Bio-0621
C06688
C43H58N4O12
CAS-13292-46-1
CCRIS 551
CHEBI:28077
CHEBI:455936
CHEMBL180
CID5381226
CID5388984
CID5458213
CID5702112
CID6604339
CID6708473
CID6842115
CID6912767
CID6913622
CPD001906767
D00211
DB01045
DRG-0109
Dione 21-acetate
Dipicin
DivK1c_000550
Doloresum
EINECS 236-312-0
Eremfat
Famcin
Fenampicin
HMS1569J11
HMS1920P08
HMS2089F12
HMS2092G09
HMS501L12
HSDB 3181
KBio1_000550
KBio2_000919
KBio2_003487
KBio2_006055
KBio3_003018
KBioGR_001780
KBioSS_000919
L-5103
L-5103 Lepetit
LS-7689
MLS000028552
MLS001148237
MLS001333745
MolPort-000-767-051
MolPort-002-513-586
MolPort-003-666-281
MolPort-006-395-891
NCGC00016699-01
NCGC00017365-01
NCGC00018178-01
NCGC00022678-03
NCGC00022678-04
NCGC00022678-05
NCGC00160500-01
 
NCI60_000309
NINDS_000550
NSC 113926
NSC-113926
NSC113926
Piperine & Rifampicin
Prestwick0_000525
Prestwick1_000525
Prestwick2_000525
Prestwick3_000525
Prestwick_833
R-Cin
R/AMP
R0079
R3501_SIAL
R3501_SIGMA
R5777_SIGMA
R7382_SIGMA
RAMP
RFP
RMP
Ramp
Reserpine & Rifampicin
Rf
Rfamipicin
Rifa
Rifadin
Rifadin (TN)
Rifadin I.V
Rifadin I.V.
Rifadin IV
Rifadin Iv
Rifadin, Rimactane, Rifampicin, Rifampin
Rifadine
Rifagen
Rifaldazin
Rifaldazine
Rifaldin
Rifam
Rifamicin AMP
Rifamor
Rifampicin
Rifampicin & EEP
Rifampicin & Propolis
Rifampicin (JP15/INN)
Rifampicin SV
Rifampicin [INN:BAN:JAN]
Rifampicin sodium
Rifampicina
Rifampicina [INN-Spanish]
Rifampicine
Rifampicine [French]
Rifampicinum
Rifampicinum [INN-Latin]
Rifampin
Rifampin (USP)
Rifampin [USAN]
Rifamsolin
Rifamycin
Rifamycin AMP
Rifamycin Amp
Rifaprodin
Rifcin
Rifinah
Rifobac
Rifoldin
Rifoldine
Riforal
Rimactan
Rimactane
Rimactane (TN)
Rimactazid
Rimactin
Rimactizid
Rimazid
Rimycin
Rofact
S1764_Selleck
SAM002264646
SMR000058322
SMR000653525
SPBio_002430
SPECTRUM1500529
STK080143
Sinerdol
Spectrum3_001837
Spectrum4_001250
Spectrum5_002018
Spectrum_000439
TNP00313
Tubocin
UNII-VJT6J7R4TR
WLN: V1 WQ A&1 E&1 E1UN- AT6N DNTJ D1
nchembio884-comp4
rifampin
3
IsoniazidapprovedPhase 313354-85-33767
Synonyms:
37271-10-6
4-pyridinecarbohydrazide
41466-07-3
5015 R.P
5015 R.P.
5015 RP
54-85-3
62229-51-0
7640-37-1
AB00052025
AC1L1GNZ
AC1Q54UP
AC1Q54UQ
AI3-23936
AKOS000119062
AZT + Isoniazid
Abdizide
Andrazide
Anidrasona
Antimicina
Antituberkulosum
Armacide
Armazid
Armazide
Atcotibine
Azuren
BB_SC-6246
BIDD:GT0140
BP 5015
BPBio1_000025
BPBio1_001322
BSPBio_000021
BSPBio_002204
Bacillin
Biomol-NT_000288
C07054
C6H7N3O
CAS-54-85-3
CCRIS 351
CHEBI:6030
CHEMBL64
CID3767
CPD000059082
Cedin
Cedin (Aerosol)
Cemidon
Chemiazid
Chemidon
Continazine
Cortinazine
Cotinazin
Cotinizin
D00346
D007538
DB00951
Defonin
Dibutin
Diforin
Dinacrin
Ditubin
DivK1c_000070
Dow-Isoniazid
EINECS 200-214-6
Ebidene
Eralon
Ertuban
Eutizon
Evalon
FRS-3
FSR 3
FSR-3
Fetefu
Fimalene
GINK
HIA
HMS1568B03
HMS1920H09
HMS2089I16
HMS2091N19
HMS500D12
HSDB 1647
Hid rasonil
Hidranizil
Hidrasonil
Hidrulta
Hidrun
Hycozid
Hydra
Hydrazid
Hydrazide
Hyozid
Hyzyd
I.A.I
I.A.I.
I0138
I14-9731
I3377_FLUKA
I3377_SIGMA
IDI1_000070
INH
INHd20
Ido-tebin
Idrazil
In-73
Inah
Inh-Burgthal
Inizid
Iscotin
Isidrina
Ismazide
Isobicina
Isocid
Isocidene
Isocotin
Isohydrazide
Isokin
Isolyn
Isonerit
Isonex
Isoniacid
Isoniazid
Isoniazid & EEP
Isoniazid & Propolis
Isoniazid SA
Isoniazida
Isoniazide
Isoniazidum
Isonicazide
Isonicid
Isonico
Isonicotan
Isonicotil
Isonicotinhydrazid
Isonicotinic acid hydrazide
Isonicotinic hydrazide
Isonicotinohydrazide
Isonicotinoyl hydrazide
Isonicotinoylhydrazide
Isonicotinsaeurehydrazid
Isonicotinyl hydrazide
Isonicotinyl hydrazine
Isonicotinylhydrazine
Isonide
Isonidrin
Isonikazid
Isonilex
Isonin
Isonindon
Isonirit
Isoniton
Isonizida
Isonizide
Isopyrin
 
Isotamine
Isotebe
Isotebezid
Isotinyl
Isozid
Isozide
Isozyd
KBio1_000070
KBio2_001333
KBio2_003901
KBio2_006469
KBio3_001424
KBioGR_000423
KBioSS_001333
L 1945
LANIZID
LS-205
Laniazid
Laniazid (TN)
Laniozid
MLS000069444
MLS001055327
MolPort-000-141-557
Mybasan
NCGC00016244-01
NCGC00016244-02
NCGC00022648-03
NCGC00022648-04
NCGC00022648-05
NCGC00022648-06
NINDS_000070
NSC 9659
NSC9659
Neo-Tizide
Neoteben
Neoxin
Neumandin
Nevin
Niadrin
Nicazide
Nicetal
Nicizina
Niconyl
Nicotibina
Nicotibine
Nicotisan
Nicozide
Nidaton
Nidrazid
Nikozid
Niplen
Nitadon
Niteban
Nitebannsc 9659
Nydrazid
Nyscozid
Oprea1_396155
Pelazid
Percin
Phthisen
Preparation 6424
Prestwick0_000161
Prestwick1_000161
Prestwick2_000161
Prestwick3_000161
Prestwick_578
Pycazide
Pyreazid
Pyricidin
Pyridicin
Pyridine-4-carboxylic acid hydrazide
Pyrizidin
RP 5015
RP-5015
RU-EF-Tb
RY-EF-Tb
Raumanon
Razide
Retozide
Rifamate
Rimicid
Rimifon
Rimiphone
Rimitsid
Robiselin
Robisellin
Roxifen
S1937_Selleck
SAM002554904
SMR000059082
SPBio_000094
SPBio_001942
SPECTRUM1500355
STK086288
Sanohidrazina
Sauterazid
Sauterzid
Spectrum2_000107
Spectrum3_000472
Spectrum4_000022
Spectrum5_000876
Spectrum_000853
Stanozide
TB-Phlogin
TB-Razide
TB-Vis
Tebecid
Tebenic
Tebexin
Tebilon
Tebos
Teebaconin
Tekazin
Tibazide
Tibemid
Tibiazide
Tibinide
Tibison
Tibivis
Tibizide
Tibusan
Tisin
Tisiodrazida
Tizide
Tubazid
Tubazide
Tubeco
Tubecotubercid
Tuberian
Tubicon
Tubilysin
Tubizid
Tubomel
Tyvid
UNII-V83O1VOZ8L
Unicocyde
Unicozyde
Usaf cb-2
Vazadrine
Vederon
WLN: T6NJ DVMZ
ZINC00001590
Zidafimia
Zinadon
Zonazide
bacillen
bp 5 015
isoco tin
isoniazid
isozid e
nchembio884-comp3
nidra zid
rimif on
tebemid
tubercid

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis PreventionRecruitingNCT02430259Phase 3
2Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat SilicosisCompletedNCT01977131Phase 1, Phase 2
3Safety of Stem Cells Intrabronchial Instillation for SilicosisCompletedNCT01239862Phase 1
4A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem CellsRecruitingNCT02668068Phase 1
5Oscillation Mechanics of the Respiratory System in Never-smoking Patients With SilicosisCompletedNCT01725971
6Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
7Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone)Not yet recruitingNCT01338064
8DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone)Not yet recruitingNCT01329003

Search NIH Clinical Center for Silicosis


Cochrane evidence based reviews: Silicosis

Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

33
Lung, Bone, Lymph node, Testes, Neutrophil, T cells, Kidney

Animal Models for Silicosis or affiliated genes

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MGI Mouse Phenotypes related to Silicosis:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.5ACE, FAS, FASLG, IL4, SCGB1A1, TGFB1
2MP:00053708.4ACE, FAS, FASLG, IL4, TGFB1, TNF
3MP:00053857.9ACE, FAS, FASLG, IL1A, IL1B, IL1RN
4MP:00020067.9ACE, FAS, FASLG, IL1A, IL1B, SCGB1A1
5MP:00053887.8FAS, FASLG, IL4, SCGB1A1, SFTPD, TGFB1
6MP:00053797.8ACE, FAS, FASLG, IL4, SCGB1A1, TGFB1
7MP:00053897.5ACE, FAS, FASLG, IL1RN, IL4, TGFB1
8MP:00107686.6ACE, FAS, FASLG, IL1B, IL1RN, IL4
9MP:00053766.2ACE, FAS, FASLG, IL1A, IL1B, IL1RN
10MP:00053975.8ACE, CXCL8, FAS, FASLG, IL1A, IL1B
11MP:00053875.6ACE, CXCL8, FAS, FASLG, IL1A, IL1B

Publications for Silicosis

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Articles related to Silicosis:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Case of accelerated silicosis in a sandblaster. (25567156)
2015
2
Pulmonary Silicosis Presents with Pleural Effusion. (26435716)
2015
3
Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People. (25374205)
2014
4
Joint effects of smoking and silicosis on diseases to the lungs. (25105409)
2014
5
Cryptococcosis, silicosis, and tuberculous pseudotumor in the same pulmonary lobe. (24310636)
2013
6
Erasmus syndrome: silicosis and systemic sclerosis. (24051915)
2013
7
Silicosis in sandblasters of shipyard versus silicosis in stone carvers in Brazil: a comparison of imaging findings, lung function variables and cardiopulmonary exercise testing parameters. (22717312)
2012
8
Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. (21346639)
2011
9
Silicotuberculosis and silicosis as occupational diseases: report of two cases. (21980669)
2011
10
Silicosis in automobile foundry workers: a 29-year cohort study. (20514987)
2010
11
A brief review of silicosis in the United States. (20523881)
2010
12
Silicosis among agate workers at Shakarpur: An analysis of clinic-based data. (21139719)
2010
13
Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners. (19882740)
2009
14
Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. (19568841)
2009
15
FDG PET findings in a case with acute pulmonary silicosis. (19866335)
2009
16
Effect of silicosis alveolar macrophages on expression of c-myc in human embryo lung fibroblast in vitro]. (19358757)
2008
17
The value of high resolution computed tomography in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to radiography. (18667790)
2008
18
Silicosis caused by sandblasting of jeans in Turkey: a report of two concomitant cases. (16096363)
2005
19
Progressive massive fibrosis secondary to pulmonary silicosis appearance on F-18 fluorodeoxyglucose PET/CT. (15483503)
2004
20
Tracheobronchopathia osteochondroplastica in a patient with silicosis: CT, bronchoscopy, and pathology findings. (15538154)
2004
21
Silicosis prevalence and exposure-response relations in South African goldminers. (15377766)
2004
22
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. (14514471)
2003
23
Silicosis in 76 men: qualitative and quantitative CT evaluation--clinical-radiologic correlation study. (12954899)
2003
24
The histogenesis of experimental silicosis. I--Methods for the histological evaluation of experimentally induced dust lesions. (2). 1960. (11899939)
2001
25
Silicosis and tuberculosis among South African goldminers--an overview of recent studies and current issues. (11544967)
2001
26
Accelerated silicosis in workers exposed to agate dust in Guangzhou, China. (11439400)
2001
27
Cohort mortality study of North American industrial sand workers. II. Case-referent analysis of lung cancer and silicosis deaths. (11295143)
2001
28
IgG subclass responses in experimental silicosis. (11570675)
2001
29
Mast cell basic fibroblast growth factor in silicosis. (10852784)
2000
30
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis. (10905501)
2000
31
Centennial photo page. Silicosis and a few of the other pneumoconiosies: observations on certain aspects of the problem, with emphasis on the role of the radiologist. 1958. (10915663)
2000
32
Pemphigus foliaceus associated with silicosis. (10951170)
2000
33
Cost-effectiveness of hospital discharge records for reaching selected endpoints in the surveillance of silicosis. (9787853)
1998
34
Persistent overexpression of interleukin-1beta and tumor necrosis factor-alpha in murine silicosis. (9546746)
1998
35
Systemic lupus erythematosus arising in a patient with chronic silicosis. (9032822)
1997
36
Photosensitivity and autoantibodies to Sm, Ro, and La in a patient with silicosis. (8876307)
1996
37
Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: studies of transforming growth factor beta expression. (8621163)
1996
38
Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography. (8800444)
1996
39
Silicosis in Brazilian pit diggers: relationship between dust exposure and radiologic findings. (7747743)
1995
40
Mortality among persons with silicosis reported to disease surveillance systems in Michigan and New Jersey in the United States. (8929696)
1995
41
The epidemiology of tuberculosis in gold miners with silicosis. (7952577)
1994
42
Cor pulmonale and silicosis: a necropsy based case-control study. (8329320)
1993
43
Correlation between radiological and pathological diagnosis of silicosis: an autopsy population based study. (8250062)
1993
44
Silicosis surveillance--Michigan, New Jersey, Ohio, and Wisconsin, 1987-1990. (8232180)
1993
45
Effect of prednisolone treatment in chronic silicosis. (2008993)
1991
46
Silicosis due to inhalation of domestic cleaning powder. (1681390)
1991
47
Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma. (2117968)
1990
48
Pneumoconiosis (silicosis) in the confectionery industry. (2345825)
1990
49
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
50
Berylliosis and silicosis. (14841360)
1951

Variations for Silicosis

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Expression for genes affiliated with Silicosis

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Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL1A, IL1B
29.6FAS, FASLG, TNF
3
Show member pathways
9.5IL1A, IL1B, IL1RN
49.5IL1A, IL1B, TNF
5
Show member pathways
9.3IL1B, TGFB1, TNF
6
Salmonella infection (KEGG)
Show member pathways
9.3IL1B, TGFB1, TNF
79.3FAS, FASLG, IL1B, TNF
89.2CXCL8, IL1B, TNF
99.2CXCL8, IL1B, TNF
109.2FASLG, IL1A, IL1B, TNF
119.2FAS, FASLG, TGFB1, TNF
12
Show member pathways
9.2FAS, FASLG, TGFB1, TNF
139.2FAS, FASLG, TGFB1, TNF
14
Apoptosis (WikiPathways)
Show member pathways
9.2FAS, FASLG, TGFB1, TNF
159.2FAS, FASLG, TNF, TNFRSF6B
169.2IL1B, IL4, TGFB1
17
Show member pathways
9.2IL1B, IL4, TGFB1
18
Show member pathways
9.1FAS, FASLG, IL4, TNF
199.1IL1A, IL1B, TGFB1, TNF
209.1IL1A, IL1B, TGFB1, TNF
21
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
22
Apoptosis (KEGG)
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
23
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
24
Show member pathways
9.0CXCL8, IL1A, IL1B, TNF
259.0CXCL8, IL1A, IL1B, TNF
269.0IL1A, IL1B, IL4, TNF
27
Show member pathways
8.9FAS, FASLG, IL1A, TNF, TNFRSF6B
288.9CXCL8, IL1A, IL1B, TGFB1
29
Show member pathways
8.8CXCL8, FASLG, IL4, TNF
308.8CXCL8, IL1B, TGFB1, TNF
318.8CXCL8, IL1B, TGFB1, TNF
328.7CXCL8, IL1A, IL1B, IL1RN, TNF
33
Show member pathways
8.7CXCL8, IL1A, IL1B, IL1RN, TNF
348.6FAS, FASLG, IL1A, IL1B, TGFB1, TNF
358.5CXCL8, IL1A, IL1B, TGFB1, TNF
36
Show member pathways
8.5IL1A, IL1B, IL4, TGFB1, TNF
378.5IL1A, IL1B, IL4, TGFB1, TNF
388.4FAS, FASLG, IL1B, IL1RN, IL4, TNF
39
Show member pathways
8.4CXCL8, IL1A, IL1B, IL4, TNF
40
B cell receptor signaling pathway (KEGG)
Show member pathways
8.3CXCL8, IL1A, IL1B, IL4, TNF
41
Show member pathways
8.0CXCL8, FAS, FASLG, IL1A, IL1B, TGFB1
42
Show member pathways
8.0FAS, FASLG, IL1A, IL1B, IL4, TGFB1
438.0CXCL8, IL1A, IL1B, IL4, TGFB1, TNF
44
Show member pathways
7.9CXCL8, FAS, FASLG, IL1A, IL1B, IL4
45
Show member pathways
7.7ACE, CXCL8, FAS, FASLG, IL1B, TGFB1
46
Show member pathways
7.5CXCL8, FAS, FASLG, IL1A, IL1B, IL4
47
Show member pathways
7.5CXCL8, FAS, FASLG, IL1A, IL1B, IL4
48
Show member pathways
7.4CXCL8, FAS, FASLG, IL1B, IL4, SFTPD
49
Show member pathways
7.1CXCL8, FAS, FASLG, IL1A, IL1B, IL4
50
Show member pathways
7.1CXCL8, FAS, FASLG, IL1A, IL1B, IL4

GO Terms for genes affiliated with Silicosis

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Cellular components related to Silicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.8IL1B, SCGB1A1, TGFB1
2external side of plasma membraneGO:00098978.9ACE, FAS, FASLG, IL4, TNF
3extracellular spaceGO:00056155.3ACE, CXCL8, FASLG, IL1A, IL1B, IL1RN
4extracellular regionGO:00055765.0ACE, CXCL8, FAS, FASLG, IL1A, IL1B

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.7FAS, FASLG
2transformed cell apoptotic processGO:000692710.6FAS, TNF
3connective tissue replacement involved in inflammatory response wound healingGO:000224810.5IL1A, TGFB1
4sequestering of triglycerideGO:003073010.5IL1B, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:006055910.5IL1B, TNF
6regulation of establishment of endothelial barrierGO:190314010.5IL1B, TNF
7negative regulation of glutamate secretionGO:001405010.5IL1B, IL1RN
8ectopic germ cell programmed cell deathGO:003523410.4IL1A, IL1B
9positive regulation of membrane protein ectodomain proteolysisGO:005104410.4IL1B, TNF
10positive regulation of interleukin-2 biosynthetic processGO:004508610.4IL1A, IL1B
11positive regulation of heterotypic cell-cell adhesionGO:003411610.4IL1B, TNF
12positive regulation of fever generationGO:003162210.4IL1B, TNF
13necroptotic signaling pathwayGO:009752710.3FAS, FASLG, TNF
14positive regulation of mononuclear cell migrationGO:007167710.3IL4, TNF
15regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.3IL1B, TNF
16response to ozoneGO:001019310.3IL1B, SCGB1A1
17extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.2FAS, FASLG, TNF
18inflammatory response to antigenic stimulusGO:000243710.2IL1A, IL1B, IL1RN
19fever generationGO:000166010.2IL1A, IL1B, IL1RN
20mononuclear cell proliferationGO:003294310.2ACE, TGFB1
21chronic inflammatory response to antigenic stimulusGO:000243910.1IL1B, IL1RN, TNF
22positive regulation of JUN kinase activityGO:004350710.1IL1B, IL1RN, TNF
23activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.1FAS, FASLG, TNF
24lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL1B, TGFB1, TNF
25protein kinase B signalingGO:00434919.9IL1B, TGFB1, TNF
26positive regulation of chemokine biosynthetic processGO:00450809.9IL1B, IL4, TNF
27positive regulation of vascular endothelial growth factor productionGO:00105759.9IL1A, IL1B, TGFB1
28extrinsic apoptotic signaling pathwayGO:00971919.9FAS, FASLG, TGFB1, TNF
29positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.8IL1B, IL4, TNF
30positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.7FASLG, IL1A, IL1B, TNF
31cellular response to organic cyclic compoundGO:00714079.7IL1B, TGFB1, TNF
32extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.6FAS, IL1A, IL1B, IL4
33positive regulation of angiogenesisGO:00457669.6CXCL8, IL1A, IL1B
34positive regulation of JNK cascadeGO:00463309.6IL1A, IL1B, TNF
35apoptotic signaling pathwayGO:00971909.6FAS, FASLG, TNF, TNFRSF6B
36negative regulation of T cell proliferationGO:00421309.5SCGB1A1, SFTPD, TGFB1
37response to glucocorticoidGO:00513849.4FAS, IL1B, IL1RN, SCGB1A1, TNF
38response to organic cyclic compoundGO:00140709.3IL1B, IL1RN, IL4, TGFB1
39positive regulation of phagocytosisGO:00507669.3IL1B, SFTPD, TNF
40positive regulation of protein phosphorylationGO:00019349.3IL1B, IL4, TGFB1, TNF
41female pregnancyGO:00075659.3IL1RN, IL4, SCGB1A1, TGFB1
42positive regulation of apoptotic processGO:00430659.2FAS, FASLG, IL1B, TGFB1, TNF
43negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.2IL1A, IL1B, TNF
44regulation of cell proliferationGO:00421279.2FAS, TGFB1, TNF, TNFRSF6B
45positive regulation of gene expressionGO:00106289.1IL1A, IL1B, TGFB1, TNF
46response to lipopolysaccharideGO:00324969.0FAS, FASLG, IL1B, IL1RN, SCGB1A1, TNFRSF6B
47apoptotic processGO:00069158.5DSG1, FAS, FASLG, IL1A, IL1B, TNFRSF6B
48response to drugGO:00424938.5IL1B, IL1RN, IL4, SCGB1A1, TGFB1
49inflammatory responseGO:00069548.2CXCL8, FAS, IL1A, IL1B, TGFB1, TNF
50immune responseGO:00069557.5CXCL8, FAS, FASLG, IL1A, IL1B, IL1RN

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.8IL1A, IL1B, IL1RN
2cytokine activityGO:00051258.0FASLG, IL1A, IL1B, IL1RN, IL4, TGFB1

Sources for Silicosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet