MCID: SLC006
MIFTS: 55

Silicosis malady

Respiratory category

Summaries for Silicosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 11/3/2010

MalaCards: Silicosis, also known as silicotuberculosis, is related to tuberculosis and pemphigus. An important gene associated with Silicosis is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds cycloheximide and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are skeleton and tumorigenesis.

Disease Ontology:8 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:64 Silicosis, (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Aliases & Classifications for Silicosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory


Aliases & Descriptions:

silicosis 8 43 10 45 61
silicotuberculosis 8 61
chronic silicosis 43 61
acute silicosis 43 61
pneumoconiosis due to other silica 8
pneumoconiosis due to silicates 8
pneumoconiosis due to silica 8
silicotic fibrosis of lung 8
silica pneumoconiosis nos 8
experimental silicosis 43
accelerated silicosis 43
silicates 8


External Ids:

Disease Ontology8 DOID:10325
MeSH35 D012829
ICD9CM27 502
NCIt40 C3369

Related Diseases for Silicosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Silicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.9IL12B, IFNGR1, SFTPD
2pemphigus30.2DSG1, DSG3
3systemic lupus erythematosus30.2IFNGR1, FAS, FASLG, IL12B, IL1RN
4pemphigus vulgaris30.1DSG3, DSG1, IL1A
5osteoarthritis29.9ACRV1, IL1A, IL1RN, IL12B
6adenocarcinoma29.9SFTPD, TNFRSF6B, FAS, FASLG, SCGB1A1, EGR1
7arthritis29.8IL1A, IL1RN
8pemphigus foliaceus29.8DSG1, DSG3
9polymyositis29.8IL1A, IL1RN, SFTPD
10idiopathic pulmonary fibrosis29.8SFTPD, FASLG, SCGB1A1, IL1RN, IL1A
11aspergillosis29.8SFTPD
12asbestosis10.6
13pulmonary tuberculosis10.4
14pulmonary function10.3
15spontaneous pneumothorax10.3
16bronchitis10.2
17anthracosis10.2
18berylliosis10.2
19synovitis10.1
20bagassosis10.1
21inflammatory bowel disease10.0IL1RN
22allergic rhinitis10.0SCGB1A1
23periodontitis10.0IL1A
24rhinitis10.0SCGB1A1
25gingivitis10.0IL1A
26bronchiolitis obliterans10.0SCGB1A1
27sarcoma10.0DSG1
28chorioamnionitis10.0IL1RN
29measles10.0IL12B
30lichen planus10.0DSG3
31thrombocytopenia10.0IL1A
32leishmaniasis10.0IFNGR1
33hepatitis10.0FASLG
34myeloma10.0FAS, FASLG
35adenoma10.0IL11RA
36cervical cancer10.0IL1A
37pemphigus vegetans10.0DSG1
38influenza10.0SFTPD
39polymyalgia rheumatica10.0IL1RN
40pituitary adenoma10.0IL1A
41thyroiditis10.0FASLG
42bullous impetigo10.0DSG1
43pulmonary fibrosis10.0SFTPD
44alopecia areata10.0IL1RN, IL1A
45uveitis10.0IL1A, TNFRSF18
46cystic fibrosis10.0SCGB1A1, SFTPD
47myeloid leukemia10.0FAS, EGR1
48atopy10.0IL12B, SCGB1A1
49fanconi's anemia10.0ZBTB32
50nephritis10.0IL1RN, SCGB1A1

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Clinical Features for Silicosis

Drugs & Therapeutics for Silicosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Silicosis

Drug clinical trials:

Search ClinicalTrials for Silicosis

Search NIH Clinical Center for Silicosis

Search CenterWatch for Silicosis

Genetic Tests for Silicosis

Anatomical Context for Silicosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Silicosis:

33
Bone marrow, Whole blood, Lymph node, Brain, Smooth muscle, Kidney, Liver, Lung, Pancreas, Skin, T cells, B lymphoblasts, B cells

Animal Models for Silicosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Silicosis

Sources:
51PubMed
See all sources

Articles related to Silicosis:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Scedosporium apiospermum brain abscesses in an immunocompetent man with silicosis. (24432222)
2013
2
Silicosis and industrial bronchitis by exposure to silica powders and cement]. (24021066)
2013
3
Silicosis in India: past and present. (23254775)
2013
4
The influence of the functional capacity on subjective well-being and quality of life of patients with silicosis. (23611697)
2013
5
Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis. (24331540)
2013
6
Pulmonary tuberculoma and miliary tuberculosis in silicosis. (23543249)
2013
7
Silicosis. (22534002)
2012
8
Silicotuberculosis and silicosis as occupational diseases: report of two cases. (21980669)
2011
9
Change of exposure response over time and long-term risk of silicosis among a cohort of Chinese pottery workers. (21845166)
2011
10
Determination of ameliorable health impairment influencing health-related quality of life among patients with silicosis in China: a cross-sectional study. (21986147)
2011
11
Assessment of serum antioxidant status in patients with silicosis. (20819424)
2010
12
Surveillance for early silicosis in high altitude miners using pulse oximetry. (18686718)
2008
13
Induced sputum markers of fibrosis and decline in pulmonary function in asbestosis and silicosis: a pilot study. (18544209)
2008
14
The burden of silicosis, pulmonary tuberculosis and COPD among former Basotho goldminers. (18566985)
2008
15
Medical image. Silicosis due to denim sandblasting: multidetector CT findings. (18480889)
2008
16
Observed and predicted silicosis risks in heavy clay workers. (17675659)
2007
17
Utilizing 2-DE and MALDI-TOF MS/MS to screen differentially expressed serum proteins of silicosis]. (17498342)
2007
18
Chronic interstitial pneumonia in silicosis and mix-dust pneumoconiosis: its prevalence and comparison of CT findings with idiopathic pulmonary fibrosis. (17400659)
2007
19
Natural course of silicosis in dust-exposed workers. (16850763)
2006
20
Cysteine cathepsins and caspases in silicosis. (16913835)
2006
21
Study on association of interleukin-1 receptor antagonist(RA) gene + 2018 locus mutation with silicosis]. (17290743)
2006
22
Conglomerated masses of silicosis in sandblasters: high-resolution CT findings. (16546338)
2006
23
Silicosis in Turkish denim sandblasters. (17021274)
2006
24
Reduced function of CD4+25+ regulatory T cell fraction in silicosis patients. (16831302)
2006
25
Silicosis caused by sandblasting of jeans in Turkey: a report of two concomitant cases. (16096363)
2005
26
Dysregulation of Fas and related molecules in silicosis patients]. (15773295)
2005
27
Risk assessment of silicosis and lung cancer among construction workers exposed to respirable quartz. (16363447)
2005
28
The role of bronchoalveolar lavage in quantifying inhaled particles in silicosis. (16288345)
2005
29
Silicosis mortality, prevention, and control--United States, 1968-2002. (15858459)
2005
30
Lifetime risk of silicosis death for quartz exposed workers among German population. (15031400)
2004
31
Potential effect of tumor necrosis factor-alpha and tumor necrosis factor receptor II gene polymorphisms on the pathogenesis of silicosis]. (15555301)
2004
32
Broncholithiasis and lithoptysis associated with silicosis. (12412703)
2002
33
Intramolecular epitope spreading among anti-caspase-8 autoantibodies in patients with silicosis, systemic sclerosis and systemic lupus erythematosus, as well as in healthy individuals. (12197899)
2002
34
Silicosis and coal workers' pneumoconiosis. (11852619)
2002
35
Significance of genetic information in risk assessment and individual classification using silicosis as a case model. (12176706)
2002
36
Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis. (11208652)
2001
37
HRCT examinations in the course of silicosis. (11977303)
2001
38
Polymorphisms of the IL-1 gene complex in coal miners with silicosis. (11241561)
2001
39
Mixed dust fibrosis and tuberculosis in comparison with silicosis and macular pneumoconiosis. (10642415)
2000
40
Lung cancer among workers compensated for silicosis in Hong Kong. (10998760)
2000
41
Mountain desert silicosis. (10778560)
1999
42
Persistent overexpression of interleukin-1beta and tumor necrosis factor-alpha in murine silicosis. (9546746)
1998
43
A silicosis patient presenting with an enlarged supraclavicular lymph node. (10201057)
1998
44
Cancer incidence and mortality among Finnish asbestos sprayers and in asbestosis and silicosis patients. (9131223)
1997
45
Photosensitivity and autoantibodies to Sm, Ro, and La in a patient with silicosis. (8876307)
1996
46
Mortality among persons with silicosis reported to disease surveillance systems in Michigan and New Jersey in the United States. (8929696)
1995
47
Silicosis among pottery workers--New Jersey. (1317504)
1992
48
Special neutrophil elastase inhibitory activity in BAL fluid from patients with silicosis and asbestosis. (2806498)
1989
49
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
50
Pulmonary alveolar proteinosis: relationship to silicosis and pulmonary infection. (7360977)
1980

Genetic Variations for Silicosis

Expression for genes affiliated with Silicosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 52QIAGEN, 56SinoBiological
See all sources

Pathways related to Silicosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4FAS, FASLG
210.4FASLG, FAS
310.3DSG1, DSG3
410.3IL12B, FASLG, FAS
5
Hide members
10.3FASLG, FAS, TNFRSF6B
6
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
10.3TNFRSF18, FAS, FASLG
710.3TNFRSF18, FASLG, EGR1
8
Hide members
10.3IL12B, IL11RA, TNFRSF18
9
Hide members
10.3IL12B, FASLG, FAS, IFNGR1
10
Apoptosis and survival Caspase cascade
Hide members
10.3IL1A, FASLG, FAS, TNFRSF6B
11
Hide members
10.2IL1A, IL1RN, EGR1, IFNGR1
12
Hide members
10.2TNFRSF6B, TNFRSF18, FAS, FASLG
13
Hide members
10.2FASLG, FAS, TNFRSF18, TNFRSF6B
14
Hide members
10.2IFNGR1, FAS, FASLG, IL12B, IL1A
15
Hide members
10.2IFNGR1, FAS, FASLG, IL12B, IL1A
16
Hide members
10.2IFNGR1, FAS, FASLG, EGR1, IGLV@
17
Immune response Bacterial infections in normal airways
Hide members
10.2IL1A, SFTPD, IFNGR1, FAS, FASLG, IL1RN
18
Hide members
10.0IFNGR1, TNFRSF6B, TNFRSF18, FAS, FASLG, IL11RA

Compounds for genes affiliated with Silicosis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Silicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.8FASLG
2indomethacin45 60 29 1113.8EGR1
3endotoxin4510.8FASLG, SCGB1A1
42-chloroethyl ethyl sulfide4510.8IL1A, IL1RN
5prednisolone45 29 1112.7SFTPD, DSG3
6imiquimod45 29 60 1113.7FASLG, IL12B, IL1A
7tetracycline45 1111.7FAS, FASLG, SCGB1A1, IL1A
8(glc)44510.7FAS, FASLG
9cellulose triacetate4510.7IL1RN, IL1A
103-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4510.7FAS, FASLG, IL1A
11sulfasalazine45 29 50 1113.7IL12B, IL1RN, IL1A
12manganese superoxide4510.7FASLG, EGR1, IL1RN, IL1A
13rantes4510.7IL1A, IL12B, FASLG, FAS
14vitamin a45 11 2412.7IL1A, FAS
15morphine45 50 29 1113.7IL1A, IL1RN, FASLG, FAS
16gp 1304510.7IL11RA, SCGB1A1, FAS, IFNGR1
17il 104510.7IL1A, IL1RN, IL12B
18hyaluronic acid45 2411.7FASLG, SCGB1A1, IL1RN, IL1A
19tgf beta14510.7IL1RN, EGR1, FASLG, FAS
20agarose4510.7IL1RN, FASLG, FAS, SFTPD
21epinephrine45 11 2412.6FAS, FASLG, EGR1, IL1RN, IL1A
22ionomycin4510.6IL1A, EGR1, FASLG, FAS
23calyculin a45 60 1112.6FAS, FASLG, EGR1
24pentoxifylline45 1111.6IL1A, IL1RN, IL12B
25paclitaxel45 50 1112.6FAS, FASLG, EGR1, IL12B, IL1A
26serine4510.6DSG3, DSG1, IL1RN, IL1A
27atpo45 2911.6FASLG, FAS
28sb 20358045 6011.6FAS, FASLG, EGR1, IL12B, IL1RN, IL1A
29ivig4510.6IL1A, IL1RN, DSG1, DSG3, FASLG, FAS
30ag 14784510.6EGR1, FASLG, FAS
31cyclosporin a45 29 6012.6FAS, FASLG, EGR1, IL1RN, IL1A
32iron45 2411.6IFNGR1, FASLG, SCGB1A1, EGR1, IL1RN
33toxin a4510.5DSG1, DSG3
34ribonucleic acid4510.5FAS, EGR1, IL1RN, IL1A
35ascorbic acid45 2411.5FAS, FASLG, IL1RN, IL1A
36dexamethasone45 50 29 1113.5SFTPD, FAS, FASLG, EGR1, CLEC3B, IL1RN
37thymidine45 2411.5SFTPD, FAS, FASLG, EGR1, IL1A
38nitric oxide45 11 2412.5SFTPD, FAS, FASLG, SCGB1A1, EGR1, IL12B
39heparin45 29 11 2413.5FAS, FASLG, CLEC3B, IL1RN, IL1A
40phosphatidylinositol4510.5SFTPD, TNFRSF6B, FAS, FASLG, SCGB1A1, EGR1
41oxygen45 2411.5SFTPD, IFNGR1, FAS, SCGB1A1, EGR1, CLEC3B
42anisomycin45 1111.5FAS, FASLG, EGR1
43h2o24510.4IL1RN, FASLG
44retinoic acid45 2411.3FAS, FASLG, EGR1, DSG1, IL1RN, IL1A
45progesterone45 60 29 11 2414.3IL1A, IL1RN, EGR1, SCGB1A1, FASLG
46polysaccharide4510.3SFTPD, FAS, FASLG, CLEC3B
47calcium45 50 11 2413.3SFTPD, FASLG, SCGB1A1, EGR1, DSG3, DSG1
48acetylcholine45 50 29 11 2414.2IL1A, DSG1, DSG3, EGR1
49vitamin d4510.2FAS, IL12B, IL1RN, IL1A
50testosterone45 60 11 2412.9FAS, FASLG, EGR1, IL1RN, IL1A

GO Terms for genes affiliated with Silicosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0TNFRSF18, FAS, FASLG, CLEC3B, IL1A, LRG1
2extracellular spaceGO:0056159.6LRG1, SFTPD, TNFRSF6B, FASLG, SCGB1A1, CLEC3B

Biological processes related to Silicosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.6FASLG, FAS
2cellular response to hyperoxiaGO:07145510.5EGR1, FAS
3response to glucocorticoid stimulusGO:05138410.4FAS, SCGB1A1, IL1RN
4apoptotic processGO:00691510.3TNFRSF6B, FAS, FASLG, DSG3, DSG1, IL1A
5regulation of cytokine productionGO:00181710.2ZBTB32, SFTPD
6negative regulation of apoptotic processGO:04306610.2TNFRSF6B, TNFRSF18, FAS, EGR1, IL1RN
7signal transductionGO:00716510.1TNFRSF18, FAS, FASLG, SCGB1A1, IL11RA, IFNGR1
8regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.1FASLG, FAS

Molecular functions related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.4IL1A, IL1RN

Products for genes affiliated with Silicosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Silicosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet