MCID: SLC006
MIFTS: 57

Silicosis malady

Rare diseases, Respiratory diseases categories

Summaries for Silicosis

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NIH Rare Diseases:43 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 11/3/2010

MalaCards based summary: Silicosis, also known as pneumoconiosis due to silicates, is related to systemic lupus erythematosus and pemphigus vulgaris. An important gene associated with Silicosis is FASLG (Fas ligand (TNF superfamily, member 6)), and among its related pathways are Signal transduction JNK pathway and Apoptosis Signaling Pathways. The compounds (glc)4 and atpo have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and bone, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:10 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:65 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Aliases & Classifications for Silicosis

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Silicosis, Aliases & Descriptions:

Name: Silicosis 32 10 43 12 45 62
Pneumoconiosis Due to Silicates 10 62
Pneumoconiosis Due to Silica 10 62
Silicotic Fibrosis of Lung 10 62
Silicotuberculosis 10 62
Chronic Silicosis 43 62
 
Acute Silicosis 43 62
Pneumoconiosis Due to Other Silica 10
Silica Pneumoconiosis Nos 10
Experimental Silicosis 43
Accelerated Silicosis 43
Silicates 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology10 DOID:10325
MeSH35 D012829
NCIt40 C3369
ICD9CM29 502

Related Diseases for Silicosis

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Diseases related to Silicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.3FAS, FASLG, IL1RN
2pemphigus vulgaris30.2DSG1, IL1A
3interstitial lung disease29.9IL1RN, IL1A
4lymphopenia29.9IL1RN, FASLG, FAS
5dermatomyositis29.9IL1RN, IL1A
6polymyositis29.9IL1A, IL1RN
7dermatitis29.9IL1A, DSG1
8lung cancer10.8
9tuberculosis10.7
10pneumoconiosis10.6
11asbestosis10.6
12pneumothorax10.4
13pulmonary tuberculosis10.4
14spontaneous pneumothorax10.3
15pulmonary function10.2
16lupus erythematosus10.2
17pemphigus10.2
18bronchitis10.2
19berylliosis10.2
20anthracosis10.2
21connective tissue disease10.2
22bagassosis10.1
23pancreatitis10.1
24pneumonia10.1
25blindness10.1
26cor pulmonale10.1
27uveitis10.0IL1A
28vogt-koyanagi-harada disease10.0FAS, FASLG
29lymphomatoid papulosis10.0FASLG, FAS
30hypersensitivity syndrome, carbamazepine-induced10.0FAS, FASLG
31autoimmune lymphoproliferative syndrome10.0FASLG, FAS
32aplastic anemia10.0FAS, FASLG
33acute graft versus host disease10.0IL1RN, FASLG
34viral hepatitis10.0FAS, FASLG
35diabetes mellitus, insulin-dependent10.0IL1RN, FASLG
36hashimoto thyroiditis10.0FAS, FASLG
37bronchopulmonary dysplasia10.0IL1RN, SCGB1A1
38graft-versus-host disease, protection against10.0FAS, FASLG
39esophageal cancer10.0FASLG, DSG1
40hepatitis10.0FASLG, FAS
41alopecia areata10.0IL1RN, IL1A
42malaria10.0IL1A, IL1RN
43juvenile rheumatoid arthritis10.0IL1A, IL1RN
44sjogren's syndrome10.0FAS, FASLG
45thyroid cancer10.0FAS, FASLG
46periodontitis10.0IL1RN, IL1A
47nephritis10.0IL1RN, SCGB1A1
48gastric adenocarcinoma10.0IL1RN, FASLG, FAS
49myositis10.0IL1A, IL1RN
50congenital human immunodeficiency virus10.0FAS, FASLG, IL1RN

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Symptoms for Silicosis

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Drugs & Therapeutics for Silicosis

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Drug clinical trials:

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Search NIH Clinical Center for Silicosis

Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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MalaCards organs/tissues related to Silicosis:

33
Lung, Lymph node, Bone, Testes, Neutrophil, Kidney, T cells, Bone marrow, Eye, Brain, Smooth muscle, Pancreas, Skin

Animal Models for Silicosis or affiliated genes

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MGI Mouse Phenotypes related to Silicosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5SCGB1A1, FAS, FASLG, IL1A
2MP:00053978.0IL1A, IL11RA, IL1RN, FASLG, FAS
3MP:00053857.7FAS, FASLG, IL1RN, IL11RA, IL1A
4MP:00053877.6IL1A, IL11RA, IL1RN, FASLG, FAS, SCGB1A1

Publications for Silicosis

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Articles related to Silicosis:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
Case of accelerated silicosis in a sandblaster. (25567156)
2015
2
Splenic calcification in a patient with silicosis. (25876588)
2015
3
Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People. (25374205)
2014
4
Joint effects of smoking and silicosis on diseases to the lungs. (25105409)
2014
5
Cryptococcosis, silicosis, and tuberculous pseudotumor in the same pulmonary lobe. (24310636)
2013
6
Erasmus syndrome: silicosis and systemic sclerosis. (24051915)
2013
7
Silicosis in sandblasters of shipyard versus silicosis in stone carvers in Brazil: a comparison of imaging findings, lung function variables and cardiopulmonary exercise testing parameters. (22717312)
2012
8
Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. (21346639)
2011
9
Silicotuberculosis and silicosis as occupational diseases: report of two cases. (21980669)
2011
10
Silicosis in automobile foundry workers: a 29-year cohort study. (20514987)
2010
11
A brief review of silicosis in the United States. (20523881)
2010
12
Silicosis among agate workers at Shakarpur: An analysis of clinic-based data. (21139719)
2010
13
Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners. (19882740)
2009
14
Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. (19568841)
2009
15
FDG PET findings in a case with acute pulmonary silicosis. (19866335)
2009
16
Effect of silicosis alveolar macrophages on expression of c-myc in human embryo lung fibroblast in vitro]. (19358757)
2008
17
The value of high resolution computed tomography in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to radiography. (18667790)
2008
18
Silicosis caused by sandblasting of jeans in Turkey: a report of two concomitant cases. (16096363)
2005
19
The recognition of silicosis: labor unions and physicians in the Chilean copper industry, 1930s-1960s. (16327085)
2005
20
Progressive massive fibrosis secondary to pulmonary silicosis appearance on F-18 fluorodeoxyglucose PET/CT. (15483503)
2004
21
Tracheobronchopathia osteochondroplastica in a patient with silicosis: CT, bronchoscopy, and pathology findings. (15538154)
2004
22
Silicosis prevalence and exposure-response relations in South African goldminers. (15377766)
2004
23
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. (14514471)
2003
24
Silicosis in 76 men: qualitative and quantitative CT evaluation--clinical-radiologic correlation study. (12954899)
2003
25
The histogenesis of experimental silicosis. I--Methods for the histological evaluation of experimentally induced dust lesions. (2). 1960. (11899939)
2001
26
Silicosis and tuberculosis among South African goldminers--an overview of recent studies and current issues. (11544967)
2001
27
Accelerated silicosis in workers exposed to agate dust in Guangzhou, China. (11439400)
2001
28
Cohort mortality study of North American industrial sand workers. II. Case-referent analysis of lung cancer and silicosis deaths. (11295143)
2001
29
IgG subclass responses in experimental silicosis. (11570675)
2001
30
Mast cell basic fibroblast growth factor in silicosis. (10852784)
2000
31
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis. (10905501)
2000
32
Centennial photo page. Silicosis and a few of the other pneumoconiosies: observations on certain aspects of the problem, with emphasis on the role of the radiologist. 1958. (10915663)
2000
33
Pemphigus foliaceus associated with silicosis. (10951170)
2000
34
Cost-effectiveness of hospital discharge records for reaching selected endpoints in the surveillance of silicosis. (9787853)
1998
35
Persistent overexpression of interleukin-1beta and tumor necrosis factor-alpha in murine silicosis. (9546746)
1998
36
Systemic lupus erythematosus arising in a patient with chronic silicosis. (9032822)
1997
37
Photosensitivity and autoantibodies to Sm, Ro, and La in a patient with silicosis. (8876307)
1996
38
Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography. (8800444)
1996
39
Silicosis in Brazilian pit diggers: relationship between dust exposure and radiologic findings. (7747743)
1995
40
Mortality among persons with silicosis reported to disease surveillance systems in Michigan and New Jersey in the United States. (8929696)
1995
41
The epidemiology of tuberculosis in gold miners with silicosis. (7952577)
1994
42
Cor pulmonale and silicosis: a necropsy based case-control study. (8329320)
1993
43
Correlation between radiological and pathological diagnosis of silicosis: an autopsy population based study. (8250062)
1993
44
Silicosis surveillance--Michigan, New Jersey, Ohio, and Wisconsin, 1987-1990. (8232180)
1993
45
Effect of prednisolone treatment in chronic silicosis. (2008993)
1991
46
Silicosis due to inhalation of domestic cleaning powder. (1681390)
1991
47
Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma. (2117968)
1990
48
Pneumoconiosis (silicosis) in the confectionery industry. (2345825)
1990
49
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
50
Berylliosis and silicosis. (14841360)
1951

Variations for Silicosis

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Expression for genes affiliated with Silicosis

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Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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Pathways related to Silicosis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7FASLG, FAS
2
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.7FASLG, FAS
3
Show member pathways
9.7FASLG, FAS
4
Show member pathways
9.7FASLG, FAS
5
Show member pathways
TRAIL signaling pathway38
9.7FAS, FASLG
69.7FAS, FASLG
79.5FASLG, IL1A
8
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.3IL1A, IL1RN
99.3IL1A, IL11RA
10
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.3FASLG, FAS, DSG1
11
Show member pathways
9.1FAS, FASLG, IL1A
12
Show member pathways
9.1FAS, FASLG, IL1A
13
Show member pathways
9.1IL1A, FASLG, FAS
14
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1IL1A, FASLG, FAS
15
Show member pathways
9.1IL1A, FASLG, FAS
16
Show member pathways
MAPK signaling pathway38
9.1IL1A, FASLG, FAS
178.9TNFRSF6B, FAS, FASLG
18
Show member pathways
8.9FASLG, FAS, TNFRSF6B
19
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.9TNFRSF6B, FAS, FASLG
20
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.9FASLG, FAS, TNFRSF6B
21
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
8.2IL1A, FASLG, FAS, TNFRSF6B
22
Show member pathways
7.7TNFRSF6B, FAS, FASLG, IL11RA, IL1A

Compounds for genes affiliated with Silicosis

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Compounds related to Silicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1(glc)44510.1FAS, FASLG
2atpo30 4511.0FASLG, FAS
3teniposide45 1310.9FASLG, FAS
4concanamycin a45 6110.8FAS, FASLG
52-chloroethyl ethyl sulfide459.8IL1RN, IL1A
6cellulose triacetate459.7IL1RN, IL1A
7polysulfone459.7FASLG, IL1RN
8imiquimod45 61 30 1312.7IL1A, FASLG
9gold sodium thiomalate459.6IL1A, IL1RN
10bromodeoxyuridine459.6SCGB1A1, FASLG, IL1RN
11cellulose acetate459.5IL1RN, FASLG
12tgf beta1459.5FAS, FASLG, IL1RN
133-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.5IL1A, FASLG, FAS
14agarose459.5IL1RN, FASLG, FAS
15gp 130459.5IL11RA, FAS, SCGB1A1
16camptothecin45 61 1311.4FAS, FASLG, IL1A
17mg 13245 6110.4IL1A, FASLG, FAS
18manganese superoxide459.4IL1A, IL1RN, FASLG
19ionomycin459.3FAS, FASLG, IL1A
20polymyxin b459.3IL1RN, IL1A
21simvastatin45 51 61 30 26 1314.3FASLG, IL1RN, IL1A
22tetracycline45 1310.1SCGB1A1, FAS, FASLG, IL1A
23ribonucleic acid459.1FAS, IL1RN, IL1A
24rapamycin459.1IL1A, FASLG, FAS
25aspartate459.0SCGB1A1, FAS, FASLG, IL1A
26hyaluronic acid45 2610.0IL1A, IL1RN, FASLG, SCGB1A1
27endotoxin459.0SCGB1A1, FASLG, IL1RN, IL1A
28morphine45 51 30 1312.0FAS, FASLG, IL1RN, IL1A
29rantes459.0FAS, FASLG, IL1RN, IL1A
30epinephrine45 26 1311.0IL1A, IL1RN, FASLG, FAS
31ascorbic acid45 2610.0FAS, FASLG, IL1RN, IL1A
32indomethacin45 30 61 1312.0IL1A, IL1RN, FASLG, FAS
33sb 20358045 619.9FAS, FASLG, IL1RN, IL1A
34vitamin d458.9IL1A, IL1RN, FAS
35cyclosporin a45 30 6110.9IL1A, IL1RN, FASLG, FAS
36progesterone45 30 61 26 1312.9IL1A, IL1RN, FASLG, SCGB1A1
37heparin45 30 26 1311.9FAS, FASLG, IL1RN, IL1A
38vitamin a45 26 1310.9SCGB1A1, FAS, IL1RN, IL1A
39cycloheximide458.9IL1A, IL1RN, FASLG, FAS
40creatinine458.9SCGB1A1, FAS, IL1RN, IL1A
41h2o2458.8IL1A, IL1RN, FASLG, FAS
42testosterone45 61 26 1311.8FAS, FASLG, IL1RN, IL1A
43dexamethasone45 51 30 1311.8FAS, FASLG, IL1RN, IL1A
44vegf458.8IL1A, IL1RN, FASLG, FAS
45paclitaxel45 51 1310.8IL1A, FASLG, FAS
46ivig458.6IL1A, IL1RN, FASLG, FAS, DSG1
47retinoic acid45 269.6DSG1, FAS, FASLG, IL1RN, IL1A
48nitric oxide45 26 1310.5SCGB1A1, FAS, FASLG, IL1RN, IL1A
49serine458.4DSG1, FAS, FASLG, IL1RN, IL1A
50phosphatidylinositol458.3TNFRSF6B, SCGB1A1, FAS, FASLG, IL1RN

GO Terms for genes affiliated with Silicosis

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Cellular components related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.8IL1A, IL1RN, FASLG, SCGB1A1, TNFRSF6B

Biological processes related to Silicosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.0FAS, FASLG
2necroptotic signaling pathwayGO:00975279.9FASLG, FAS
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012399.9FASLG, FAS
4extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.8FASLG, FAS
5extrinsic apoptotic signaling pathwayGO:00971919.8FASLG, FAS
6fever generationGO:00016609.6IL1A, IL1RN
7female pregnancyGO:00075659.5IL1RN, SCGB1A1
8extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.5IL1A, FAS
9response to lipopolysaccharideGO:00324969.4SCGB1A1, FASLG, IL1RN
10activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.4FASLG, FAS
11response to glucocorticoidGO:00513849.3SCGB1A1, FAS, IL1RN
12immune responseGO:00069559.0FASLG, IL1RN, IL1A
13signal transductionGO:00071658.9SCGB1A1, FAS, FASLG, IL11RA
14negative regulation of apoptotic processGO:00430668.6IL1RN, FAS, TNFRSF6B
15apoptotic processGO:00069158.1IL1A, FASLG, FAS, DSG1, TNFRSF6B

Molecular functions related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.3IL1A, IL1RN

Products for genes affiliated with Silicosis

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Sources for Silicosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet