MCID: SLC006
MIFTS: 53

Silicosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

About this section

Aliases & Descriptions for Silicosis:

Name: Silicosis 35 11 48 50 39 13 68
Silicotuberculosis 11 68
Chronic Silicosis 48 68
Acute Silicosis 48 68
Pneumoconiosis Due to Silicates 11
 
Silicotic Fibrosis of Lung 11
Experimental Silicosis 48
Silica Pneumoconiosis 11
Accelerated Silicosis 48

Classifications:



External Ids:

Disease Ontology11 DOID:10325
ICD1030 J62, J62.8
ICD9CM32 502
MeSH39 D012829
NCIt45 C3369

Summaries for Silicosis

About this section
NIH Rare Diseases:48 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. Simple chronic silicosis may cause people to have difficulty breathing.  Accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. Swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months.  People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. Last updated: 12/17/2015

MalaCards based summary: Silicosis, also known as silicotuberculosis, is related to pneumoconiosis due to talc and pulmonary hypertension. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways are Interleukin-1 processing and RXR and RAR heterodimerization with other nuclear receptor. Affiliated tissues include lung, bone and lymph node, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and renal/urinary system.

Disease Ontology:11 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:71 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Related Diseases for Silicosis

About this section

Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1pneumoconiosis due to talc31.1TGFB1, TNF
2pulmonary hypertension30.2IL1B, TNF
3lymphopenia29.9CXCL8, IL1B, TNF
4asbestosis27.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
5asthma27.0CXCL8, FAS, IL1A, IL1B, IL1RN, NLRP3
6anthracosis11.1
7interstitial lung disease10.8
8thyroid malformation10.7IL1B, TNF
9hypospadias, hypertelorism, upper lid coloboma, and mixed-type hearing loss10.7IL1B, TNF
10baetz-greenwalt syndrome10.6IL1B, TNF
11pediatric systemic lupus erythematosus10.6FAS, FASLG
12diabetic cataract10.6IL1A, IL1B
13granulomatous gastritis10.6FAS, FASLG
14corneal deposit10.6CXCL8, IL1B
15basidiobolomycosis10.6CXCL8, TNF
16tarsal tunnel syndrome10.6CXCL8, IL1B
17small intestine lymphoma10.5IL1A, TNF
18gastric cancer risk after h. pylori infection10.5IL1B, IL1RN
1912p12.1 microdeletion syndrome10.5FAS, FASLG, TNF
20cartilage disease10.5IL1B, TNF
21maligant granulosa cell tumor of ovary10.5CXCL8, TNF
22parsonage turner syndrome10.5TGFB1, TNF
23calpainopathy10.5FAS, TGFB1
24myopathy-growth delay-intellectual disability-hypospadias syndrome10.5TGFB1, TNF
25non-secretory myeloma10.5IL1B, IL1RN, TNF
26benign breast adenomyoepithelioma10.5FAS, FASLG, IL1B
27keloids10.5IL1B, IL1RN, TNF
28epstein-barr virus hepatitis10.5IL1A, TNF
29senile cataract10.5IL1B, IL1RN, TNF
30rectosigmoid junction neoplasm10.5IL1A, IL1B, TNF
31skin disease10.4CXCL8, IL1B, TNF
32benign lymphoepithelial lesion of salivary gland10.4IL1A, IL1B, TNF
33sternum lymphoma10.4IL1B, IL1RN, TNF
34paraphimosis10.4CXCL8, IL1B, TNF
35qualitative platelet defect10.4CXCL8, IL1B, TNF
36paraneoplastic polyneuropathy10.4CXCL8, IL1B, TNF
37inner ear cancer10.4CXCL8, IL1B, TNF
38duodenum cancer10.4FAS, TNF
39benign adult familial myoclonic epilepsy10.4CXCL8, FAS
40kidney angiomyolipoma10.4CXCL8, IL1B, TNF
41cervix erosion10.4CXCL8, IL1B, TNF
42intestinal variant cervical mucinous adenocarcinoma10.4CXCL8, IL1B, TNF
43mental retardation anophthalmia craniosynostosis10.4IL1A, IL1B, IL1RN
44dementia - subcortical10.4CXCL8, FAS, TNF
45bacteriuria10.4CXCL8, IL1B, TNF
46contact blepharoconjunctivitis10.4CXCL8, IL1B
47amelogenesis imperfecta10.4CXCL8, IL1B, TNF
48mononeuritis of lower limb10.4CXCL8, IL1B, TNF
49lateral sclerosis10.4CXCL8, IL1B, TNF
50mandibular cancer10.4CXCL8, IL1B, TNF

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


AnthracosisBronchitis
Heart DiseasePostinflammatory Pulmonary Fibrosis
Prostatic HypertrophyRespiratory Failure

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Symptoms & Phenotypes for Silicosis

About this section

GenomeRNAi Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-13.9ACE, CXCL8, FAS, FASLG, IL1A, IL1B

MGI Mouse Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

41 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1ACE, FAS, FASLG, NLRP3, SCGB1A1, TGFB1
2MP:00053709.1ACE, FAS, FASLG, NLRP3, TGFB1, TNF
3MP:00053888.9FAS, FASLG, SCGB1A1, SFTPD, TGFB1, TNF
4MP:00053898.8ACE, FAS, FASLG, IL1RN, NLRP3, TGFB1
5MP:00107718.7FAS, FASLG, IL1A, IL1B, IL1RN, NLRP3
6MP:00053858.6ACE, FAS, FASLG, IL1A, IL1B, IL1RN
7MP:00020068.6ACE, FAS, FASLG, IL1A, IL1B, SCGB1A1
8MP:00053908.5DSG1, FAS, FASLG, IL1B, IL1RN, NLRP3
9MP:00053977.4ACE, FAS, FASLG, IL1A, IL1B, IL1RN
10MP:00107687.3ACE, FAS, FASLG, IL1B, IL1RN, NLRP3
11MP:00053767.1ACE, FAS, FASLG, IL1A, IL1B, IL1RN
12MP:00053876.4ACE, CCL2, FAS, FASLG, IL1A, IL1B

Drugs & Therapeutics for Silicosis

About this section

Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IsoniazidapprovedPhase 315054-85-33767
Synonyms:
37271-10-6
4-pyridinecarbohydrazide
41466-07-3
5015 R.P
5015 R.P.
5015 RP
54-85-3
62229-51-0
7640-37-1
AB00052025
AC1L1GNZ
AC1Q54UP
AC1Q54UQ
AI3-23936
AKOS000119062
AZT + Isoniazid
Abdizide
Andrazide
Anidrasona
Antimicina
Antituberkulosum
Armacide
Armazid
Armazide
Atcotibine
Azuren
BB_SC-6246
BIDD:GT0140
BP 5015
BPBio1_000025
BPBio1_001322
BSPBio_000021
BSPBio_002204
Bacillin
Biomol-NT_000288
C07054
C6H7N3O
CAS-54-85-3
CCRIS 351
CHEBI:6030
CHEMBL64
CID3767
CPD000059082
Cedin
Cedin (Aerosol)
Cemidon
Chemiazid
Chemidon
Continazine
Cortinazine
Cotinazin
Cotinizin
D00346
D007538
DB00951
Defonin
Dibutin
Diforin
Dinacrin
Ditubin
DivK1c_000070
Dow-Isoniazid
EINECS 200-214-6
Ebidene
Eralon
Ertuban
Eutizon
Evalon
FRS-3
FSR 3
FSR-3
Fetefu
Fimalene
GINK
HIA
HMS1568B03
HMS1920H09
HMS2089I16
HMS2091N19
HMS500D12
HSDB 1647
Hid rasonil
Hidranizil
Hidrasonil
Hidrulta
Hidrun
Hycozid
Hydra
Hydrazid
Hydrazide
Hyozid
Hyzyd
I.A.I
I.A.I.
I0138
I14-9731
I3377_FLUKA
I3377_SIGMA
IDI1_000070
INH
INHd20
Ido-tebin
Idrazil
In-73
Inah
Inh-Burgthal
Inizid
Iscotin
Isidrina
Ismazide
Isobicina
Isocid
Isocidene
Isocotin
Isohydrazide
Isokin
Isolyn
Isonerit
Isonex
Isoniacid
Isoniazid
Isoniazid & EEP
Isoniazid & Propolis
Isoniazid SA
Isoniazida
Isoniazide
Isoniazidum
Isonicazide
Isonicid
Isonico
Isonicotan
Isonicotil
Isonicotinhydrazid
Isonicotinic acid hydrazide
Isonicotinic hydrazide
Isonicotinohydrazide
Isonicotinoyl hydrazide
Isonicotinoylhydrazide
Isonicotinsaeurehydrazid
Isonicotinyl hydrazide
Isonicotinyl hydrazine
Isonicotinylhydrazine
Isonide
Isonidrin
Isonikazid
Isonilex
Isonin
Isonindon
Isonirit
Isoniton
Isonizida
Isonizide
Isopyrin
 
Isotamine
Isotebe
Isotebezid
Isotinyl
Isozid
Isozide
Isozyd
KBio1_000070
KBio2_001333
KBio2_003901
KBio2_006469
KBio3_001424
KBioGR_000423
KBioSS_001333
L 1945
LANIZID
LS-205
Laniazid
Laniazid (TN)
Laniozid
MLS000069444
MLS001055327
MolPort-000-141-557
Mybasan
NCGC00016244-01
NCGC00016244-02
NCGC00022648-03
NCGC00022648-04
NCGC00022648-05
NCGC00022648-06
NINDS_000070
NSC 9659
NSC9659
Neo-Tizide
Neoteben
Neoxin
Neumandin
Nevin
Niadrin
Nicazide
Nicetal
Nicizina
Niconyl
Nicotibina
Nicotibine
Nicotisan
Nicozide
Nidaton
Nidrazid
Nikozid
Niplen
Nitadon
Niteban
Nitebannsc 9659
Nydrazid
Nyscozid
Oprea1_396155
Pelazid
Percin
Phthisen
Preparation 6424
Prestwick0_000161
Prestwick1_000161
Prestwick2_000161
Prestwick3_000161
Prestwick_578
Pycazide
Pyreazid
Pyricidin
Pyridicin
Pyridine-4-carboxylic acid hydrazide
Pyrizidin
RP 5015
RP-5015
RU-EF-Tb
RY-EF-Tb
Raumanon
Razide
Retozide
Rifamate
Rimicid
Rimifon
Rimiphone
Rimitsid
Robiselin
Robisellin
Roxifen
S1937_Selleck
SAM002554904
SMR000059082
SPBio_000094
SPBio_001942
SPECTRUM1500355
STK086288
Sanohidrazina
Sauterazid
Sauterzid
Spectrum2_000107
Spectrum3_000472
Spectrum4_000022
Spectrum5_000876
Spectrum_000853
Stanozide
TB-Phlogin
TB-Razide
TB-Vis
Tebecid
Tebenic
Tebexin
Tebilon
Tebos
Teebaconin
Tekazin
Tibazide
Tibemid
Tibiazide
Tibinide
Tibison
Tibivis
Tibizide
Tibusan
Tisin
Tisiodrazida
Tizide
Tubazid
Tubazide
Tubeco
Tubecotubercid
Tuberian
Tubicon
Tubilysin
Tubizid
Tubomel
Tyvid
UNII-V83O1VOZ8L
Unicocyde
Unicozyde
Usaf cb-2
Vazadrine
Vederon
WLN: T6NJ DVMZ
ZINC00001590
Zidafimia
Zinadon
Zonazide
bacillen
bp 5 015
isoco tin
isoniazid
isozid e
nchembio884-comp3
nidra zid
rimif on
tebemid
tubercid
2
RifampinapprovedPhase 333713292-46-15458213, 5381226
Synonyms:
1-b]furan-21-yl acetate
13292-46-1
3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(4-Methylpiperazinyliminomethyl)-rifamycin SV
3-(4-Methylpiperazinyliminomethyl)rifamycin SV
3-([(4-Methyl-1-piperazinyl)imino]methyl)rifamycin SV
3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV
3-[[(4-Methyl-1-piperazinyl)imino]-methyl]rifamycin
46713_FLUKA
46713_RIEDEL
62534-43-4
8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV
8-(4-Methylpiperazinyliminomethyl) rifamycin SV
8-[[(4-Methyl-1-piperazinyl)imino[methyl]rifamycin
8-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin sv
8-[[(4-Methylpiperazinyl)imino]methyl]rifamycin sv
83907_FLUKA
83907_SIGMA
8CI)
AZT + Rifampin
Abrifam
Archidyn
Arficin
Arzide
BA-41166E
BIDD:PXR0014
BPBio1_000561
BSPBio_000509
Ba 41166
Ba 41166/E
Benemicin
Benemycin
Bio-0621
C06688
C43H58N4O12
CAS-13292-46-1
CCRIS 551
CHEBI:28077
CHEBI:455936
CHEMBL180
CID5381226
CID5388984
CID5458213
CID5702112
CID6604339
CID6708473
CID6842115
CID6912767
CID6913622
CPD001906767
D00211
DB01045
DRG-0109
Dione 21-acetate
Dipicin
DivK1c_000550
Doloresum
EINECS 236-312-0
Eremfat
Famcin
Fenampicin
HMS1569J11
HMS1920P08
HMS2089F12
HMS2092G09
HMS501L12
HSDB 3181
KBio1_000550
KBio2_000919
KBio2_003487
KBio2_006055
KBio3_003018
KBioGR_001780
KBioSS_000919
L-5103
L-5103 Lepetit
LS-7689
MLS000028552
MLS001148237
MLS001333745
MolPort-000-767-051
MolPort-002-513-586
MolPort-003-666-281
MolPort-006-395-891
NCGC00016699-01
NCGC00017365-01
NCGC00018178-01
NCGC00022678-03
NCGC00022678-04
NCGC00022678-05
NCGC00160500-01
 
NCI60_000309
NINDS_000550
NSC 113926
NSC-113926
NSC113926
Piperine & Rifampicin
Prestwick0_000525
Prestwick1_000525
Prestwick2_000525
Prestwick3_000525
Prestwick_833
R-Cin
R/AMP
R0079
R3501_SIAL
R3501_SIGMA
R5777_SIGMA
R7382_SIGMA
RAMP
RFP
RMP
Ramp
Reserpine & Rifampicin
Rf
Rfamipicin
Rifa
Rifadin
Rifadin (TN)
Rifadin I.V
Rifadin I.V.
Rifadin IV
Rifadin Iv
Rifadin, Rimactane, Rifampicin, Rifampin
Rifadine
Rifagen
Rifaldazin
Rifaldazine
Rifaldin
Rifam
Rifamicin AMP
Rifamor
Rifampicin
Rifampicin & EEP
Rifampicin & Propolis
Rifampicin (JP15/INN)
Rifampicin SV
Rifampicin [INN:BAN:JAN]
Rifampicina
Rifampicina [INN-Spanish]
Rifampicine
Rifampicine [French]
Rifampicinum
Rifampicinum [INN-Latin]
Rifampin
Rifampin (USP)
Rifampin [USAN]
Rifamsolin
Rifamycin
Rifamycin AMP
Rifamycin Amp
Rifaprodin
Rifcin
Rifinah
Rifobac
Rifoldin
Rifoldine
Riforal
Rimactan
Rimactane
Rimactane (TN)
Rimactazid
Rimactin
Rimactizid
Rimazid
Rimycin
Rofact
S1764_Selleck
SAM002264646
SMR000058322
SMR000653525
SPBio_002430
SPECTRUM1500529
STK080143
Sinerdol
Spectrum3_001837
Spectrum4_001250
Spectrum5_002018
Spectrum_000439
TNP00313
Tubocin
UNII-VJT6J7R4TR
WLN: V1 WQ A&1 E&1 E1UN- AT6N DNTJ D1
nchembio884-comp4
rifampin
3
RifapentineapprovedPhase 33061379-65-56323497
Synonyms:
(2R,16S,17R,18R,19R,20S,21S,22S,23S)-8-{[(4-CYCLOPENTYLPIPERAZIN-1-YL)IMINO]METHYL}-5,6,9,17,19-PENTAHYDROXY-23-METHOXY-2,4,12,16,18,20,22-HEPTAMETHYL-1,11-DIOXO-1,2-DIHYDRO-2,7-(EPOXYPENTADECA[1,11,13]TRIENOIMINO)NAPHTHO[2,1-B]FURAN-21-YL ACETATE
(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-{(E)-[(4-cyclopentylpiperazin-1-yl)imino]methyl}-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin
3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin SV
3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV
3-(N-(4-Cyclopentyl-1-piperazinyl)formimidoyl)rifamycin
3-[N-(4-Cyclopentyl-1-piperazinyl)formimidoyl]rifamycin
61379-65-5
71950-35-1
Ambap127923-87-9
Antibiotic DL 473IT
BIDD:GT0669
C08059
C47H64N4O12
CHEBI:45304
CHEMBL1660
CID6323497
CID6434610
CID6835847
CID9919168
CPD000466332
CPD001906779
Cyclopentyl rifampin
Cyclopentylrifampicin
D00879
DB01201
DL 473
DL 473-IT
DL-4-73
DL-473
DL473
DRG-0283
 
EINECS 262-743-9
HMS2051D16
KTC 1
LS-143825
M000473
MDL 473
MDL-473
MDL473
MLS000759441
MLS001424209
NCGC00167431-01
Priftin
Priftin (TN)
Priftin (tn)
Priftin, Cyclopentylrifampicin, Rifapentine
R 77-3
R-773
RIFAPENTINE
RPE
RPT
Rifamycin AF/ACPP
Rifapentin
Rifapentina
Rifapentina [Spanish]
Rifapentine (USAN/INN)
Rifapentine [USAN:BAN:INN]
Rifapentinum
Rifapentinum [Latin]
S1760_Selleck
SAM001246620
SAM002589953
SMR000466332
UNII-XJM390A33U
4Lipid Regulating AgentsPhase 32702
5Nucleic Acid Synthesis InhibitorsPhase 34855
6Anti-Bacterial AgentsPhase 310884
7Hypolipidemic AgentsPhase 32721
8Antibiotics, AntitubercularPhase 36972
9Cytochrome P-450 CYP3A InducersPhase 31101
10Anti-Infective AgentsPhase 321402
11AntimetabolitesPhase 311774
12Antitubercular AgentsPhase 31272
13MitogensPhase 1, Phase 21526
14Respiratory System Agents4818

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis PreventionRecruitingNCT02430259Phase 3
2Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat SilicosisCompletedNCT01977131Phase 1, Phase 2
3Safety of Stem Cells Intrabronchial Instillation for SilicosisCompletedNCT01239862Phase 1
4A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem CellsRecruitingNCT02668068Phase 1
5Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone)Unknown statusNCT01338064
6DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone)Unknown statusNCT01329003
7Oscillation Mechanics of the Respiratory System in Never-smoking Patients With SilicosisCompletedNCT01725971
8Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
9Comprehensive Risk Assessment of People With Silicosis: A Population-based StudyRecruitingNCT02794701

Search NIH Clinical Center for Silicosis


Cochrane evidence based reviews: silicosis

Genetic Tests for Silicosis

About this section

Anatomical Context for Silicosis

About this section

MalaCards organs/tissues related to Silicosis:

36
Lung, Bone, Lymph node, Bone marrow, Testes, Neutrophil, T cells

Publications for Silicosis

About this section

Articles related to Silicosis:

(show top 50)    (show all 640)
idTitleAuthorsYear
1
Infodemiological data concerning silicosis in the USA in the period 2004-2010 correlating with real-world statistical data. (28054008)
2017
2
A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy. (27516887)
2016
3
Effects of bone marrow-derived mesenchymal stem cells on the autophagic activity of alveolar macrophages in a rat model of silicosis. (27284351)
2016
4
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. (26977968)
2016
5
Bronchoalveolar Lavage Fluid microRNA-146a: A Biomarker of Disease Severity and Pulmonary Function in Patients With Silicosis. (27158964)
2016
6
Proteomic profiling change during the early development of silicosis disease. (27076927)
2016
7
Global DNA methylation and PTEN hypermethylation alterations in lung tissues from human silicosis. (27621875)
2016
8
Proteomic profiling differences in serum from silicosis and chronic bronchitis patients: a comparative analysis. (27076939)
2016
9
Computed Tomography and Magnetic Resonance Imaging for Longitudinal Characterization of Lung Structure Changes in a Yucatan Miniature Pig Silicosis Model. (26839326)
2016
10
Cell-Based Therapy for Silicosis. (27066079)
2016
11
Silicosis with Various Clinical Courses in a Tunnel Worker: A Case Report. (27517002)
2016
12
Progressive multifocal leukoencephalopathy in a patient with silicosis. (27416854)
2016
13
Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis. (26789403)
2016
14
Recurrent Tracheal Stenosis: A Novel Presentation of Silicosis. (27388408)
2016
15
Denim production and silicosis. (26807688)
2016
16
SB203580 inhibits epithelial-mesenchymal transition and pulmonary fibrosis in a rat silicosis model. (27480278)
2016
17
Silicosis and silicotuberculosis in India. (27843169)
2016
18
Endobronchial Silicosis and Tuberculosis Presenting as the Right Middle Lobe Syndrome. (27764010)
2016
19
Fatal silicosis in a funeral arts' craftsman. (27976666)
2016
20
A study on silicosis among employees of a silica processing factory in the Central Province of Sri Lanka. (27031972)
2016
21
Leveraging Big Data for Exploring Occupational Diseases-Related Interest at the Level of Scientific Community, Media Coverage and Novel Data Streams: The Example of Silicosis as a Pilot Study. (27806115)
2016
22
Silica, Silicosis, and Autoimmunity. (27014276)
2016
23
CT-guided aspiration cytology of advanced silicosis and confirmation of the deposited zeolite nano particles through X ray diffraction: A novel approach. (26748653)
2016
24
Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-I^1/ROCK1 pathway in silicosis in rat. (26785300)
2016
25
Genome-wide analysis of aberrantly expressed microRNAs in bronchoalveolar lavage fluid from patients with silicosis. (26903263)
2016
26
Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis. (27014274)
2016
27
Biometric monitoring in silicosis to detect early disease and monitor lung injury: not quite there. (27995129)
2016
28
Silicosis, tuberculosis time bomb? (27601099)
2016
29
Down-Regulation of miR-19a as a Biomarker for Early Detection of Silicosis. (27312312)
2016
30
Lung cancer in patients diagnosed with silicosis should be investigated. (27330963)
2016
31
Tadalafil reduces airway hyperactivity and protects against lung and respiratory airways dysfunction in a rat model of silicosis. (27769022)
2016
32
Can silicosis explain it all? (27650457)
2016
33
Biometric monitoring in silicosis to detect early disease and monitor lung injury: not quite there. (27995130)
2016
34
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in a rare case of carcinoma stomach with concomitant silicosis. (27833322)
2016
35
Radiological Evaluation of Artificial Stone Silicosis Outbreak: Emphasizing Findings in Lung Transplant Recipients. (27680410)
2016
36
Surveillance for Silicosis - Michigan and New Jersey, 2003-2011. (27736836)
2016
37
Dynamic changes of mononuclear phagocytes in circulating, pulmonary alveolar and interstitial compartments in a mouse model of experimental silicosis. (27240636)
2016
38
Effect of Xinjiang Uyghur Vernonia anthelmintica Willd Injection Treatment with Silicosis Fibrosis. (27803925)
2016
39
Deadly denim: sandblasting-induced silicosis in the jeans industry. (27155769)
2016
40
Case of accelerated silicosis in a sandblaster. (25567156)
2015
41
Pulmonary Silicosis Presents with Pleural Effusion. (26435716)
2015
42
From the 1930 International Johannesburg conference on silicosis, to "tables" of occupational diseases, France, 2000 onward: A comparative reading. (26509754)
2015
43
From silicosis to silica hazards: An experiment in medicine, history, and the social sciences. (26358619)
2015
44
Serum autoantibodies in silicosis and non-silicosis cement workers. (25564983)
2015
45
Treating pulmonary silicosis by blocking interleukin 1. (25723826)
2015
46
Six cases of silicosis: implications for health surveillance of stonemasons. (25744972)
2015
47
The pathologist's view of silicosis in 1930 and in 2015. The Johannesburg Conference legacy. (26509753)
2015
48
Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance for Silicosis - Michigan and New Jersey, 2003-2010. (26505318)
2015
49
Effect of bone morphogenic protein-7 on the expression of epithelial-mesenchymal transition markers in silicosis model. (25773679)
2015
50
Contributions of the high resolution computed tomography in the early detection of silicosis. (25596993)
2015

Variations for Silicosis

About this section

Expression for genes affiliated with Silicosis

About this section
Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

About this section

Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL1A, IL1B
29.7TGFB1, TNF
39.7IL1B, TGFB1
49.7FAS, FASLG, TNF
5
Show member pathways
9.5IL1A, IL1B, IL1RN
69.5IL1A, IL1B, TNF
79.5IL1A, IL1B, TNF
89.5FAS, TGFB1, TNF
9
Show member pathways
9.4CXCL8, FASLG, TNF
10
Show member pathways
9.4FAS, FASLG, IL1A, TNF
119.4IL1B, TGFB1, TNF
12
Show member pathways
9.4IL1B, TGFB1, TNF
13
Show member pathways
9.3CXCL8, IL1A, IL1B
149.3FAS, FASLG, IL1B, TNF
159.3CXCL8, IL1B, TNF
169.3CXCL8, IL1B, TNF
179.3FASLG, IL1A, IL1B, TNF
189.2FAS, FASLG, TGFB1, TNF
19
Show member pathways
9.2FAS, FASLG, TGFB1, TNF
209.2FAS, FASLG, TGFB1, TNF
219.2CCL2, IL1B, TNF
229.2CCL2, IL1B, TNF
239.1IL1A, IL1B, TGFB1, TNF
24
Show member pathways
9.1IL1A, IL1B, TGFB1, TNF
259.1IL1A, IL1B, TGFB1, TNF
269.1IL1A, IL1B, TGFB1, TNF
27
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
28
Show member pathways
9.0FAS, FASLG, IL1A, IL1B, TNF
29
Show member pathways
9.0CXCL8, IL1A, IL1B, TNF
30
Show member pathways
9.0CXCL8, IL1A, IL1B, TNF
318.9CCL2, FAS, IL1B, TNF
328.9CXCL8, IL1A, IL1B, TGFB1
338.8CXCL8, IL1B, TGFB1, TNF
34
Show member pathways
8.8FAS, IL1A, IL1B, TGFB1, TNF
358.7CXCL8, IL1A, IL1B, IL1RN, TNF
368.6FAS, FASLG, IL1A, IL1B, TGFB1, TNF
37
Show member pathways
8.6FAS, FASLG, IL1A, IL1B, TGFB1, TNF
388.5CXCL8, IL1A, IL1B, NLRP3, TNF
398.4CCL2, FAS, FASLG, IL1B, IL1RN, TNF
40
Show member pathways
8.3CCL2, CXCL8, IL1A, IL1B, TGFB1
418.2CCL2, CXCL8, IL1B, TGFB1, TNF
42
Show member pathways
8.2CXCL8, IL1A, IL1B, IL1RN, NLRP3, TNF
43
Show member pathways
8.2CCL2, CXCL8, IL1B, NLRP3, TNF
448.1CCL2, CXCL8, FASLG, IL1A, IL1B, TNF
457.9CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
467.9CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
477.9CCL2, CXCL8, IL1A, IL1B, TGFB1, TNF
48
Show member pathways
7.9CXCL8, FAS, FASLG, IL1B, SFTPD, TNF
49
Show member pathways
7.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B
50
Show member pathways
7.4CCL2, CXCL8, FAS, FASLG, IL1A, IL1B

GO Terms for genes affiliated with Silicosis

About this section

Cellular components related to Silicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.9ACE, FAS, FASLG, TNF
2secretory granuleGO:00301419.2FAS, IL1B, SCGB1A1, TGFB1
3extracellular regionGO:00055766.1ACE, CCL2, CXCL8, FAS, FASLG, IL1A
4extracellular spaceGO:00056156.0ACE, CCL2, CXCL8, FAS, FASLG, IL1A

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idNameGO IDScoreTop Affiliating Genes
1activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.8FAS, FASLG
2inflammatory cell apoptotic processGO:000692510.8FAS, FASLG
3regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.7FAS, FASLG
4response to growth factorGO:007084810.7FAS, FASLG
5ectopic germ cell programmed cell deathGO:003523410.6IL1A, IL1B
6fever generationGO:000166010.6IL1A, IL1B
7connective tissue replacement involved in inflammatory response wound healingGO:000224810.6IL1A, TGFB1
8positive regulation of interleukin-2 biosynthetic processGO:004508610.6IL1A, IL1B
9chronic inflammatory response to antigenic stimulusGO:000243910.6IL1B, TNF
10positive regulation of monocyte chemotactic protein-1 productionGO:007163910.6IL1A, IL1B
11response to ozoneGO:001019310.6IL1B, SCGB1A1
12negative regulation of lipid catabolic processGO:005099510.6IL1B, TNF
13positive regulation of calcidiol 1-monooxygenase activityGO:006055910.6IL1B, TNF
14positive regulation of chemokine biosynthetic processGO:004508010.6IL1B, TNF
15positive regulation of fever generationGO:003162210.6IL1B, TNF
16positive regulation of heterotypic cell-cell adhesionGO:003411610.6IL1B, TNF
17positive regulation of membrane protein ectodomain proteolysisGO:005104410.5IL1B, TNF
18regulation of establishment of endothelial barrierGO:190314010.5IL1B, TNF
19regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.5IL1B, TNF
20sequestering of triglycerideGO:003073010.5IL1B, TNF
21positive regulation of mononuclear cell migrationGO:007167710.5TGFB1, TNF
22positive regulation of protein complex assemblyGO:003133410.5TGFB1, TNF
23apoptotic signaling pathwayGO:009719010.5FAS, FASLG, TNF
24positive regulation of histone acetylationGO:003506610.5IL1B, TGFB1
25extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.5FAS, FASLG, TNF
26necroptotic signaling pathwayGO:009752710.5FAS, FASLG, TNF
27interleukin-1 beta productionGO:003261110.4IL1B, NLRP3
28embryonic digestive tract developmentGO:004856610.4CXCL8, TNF
29extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.4FAS, IL1A, IL1B
30mononuclear cell proliferationGO:003294310.3ACE, TGFB1
31negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.3IL1A, IL1B, TNF
32positive regulation of interleukin-6 productionGO:003275510.3IL1A, IL1B, TNF
33positive regulation of JNK cascadeGO:004633010.3IL1A, IL1B, TNF
34cellular response to mechanical stimulusGO:007126010.2FAS, IL1B, TGFB1
35response to organic substanceGO:001003310.2SCGB1A1, TGFB1, TNF
36positive regulation of cell divisionGO:005178110.2IL1A, IL1B, TGFB1
37positive regulation of vascular endothelial growth factor productionGO:001057510.2IL1A, IL1B, TGFB1
38PERK-mediated unfolded protein responseGO:003649910.1CCL2, CXCL8
39positive regulation of angiogenesisGO:004576610.1CXCL8, IL1A, IL1B
40extrinsic apoptotic signaling pathwayGO:009719110.1FAS, FASLG, TGFB1, TNF
41maternal process involved in female pregnancyGO:006013510.0CCL2, DSG1, FAS
42positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.0FASLG, IL1A, IL1B, TNF
43activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.0FAS, FASLG, NLRP3, TNF
44cellular response to interleukin-1GO:00713479.9CCL2, CXCL8, FAS
45positive regulation of gene expressionGO:00106289.9IL1A, IL1B, TGFB1, TNF
46response to progesteroneGO:00325709.8CCL2, DSG1, TGFB1
47macrophage chemotaxisGO:00482469.8CCL2, SFTPD
48negative regulation of T cell proliferationGO:00421309.8SCGB1A1, SFTPD, TGFB1
49neutrophil chemotaxisGO:00305939.7CCL2, CXCL8, IL1B
50positive regulation of phagocytosisGO:00507669.7IL1B, SFTPD, TNF

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.8IL1A, IL1B
2cytokine activityGO:00051258.2CCL2, FASLG, IL1A, IL1B, IL1RN, TGFB1

Sources for Silicosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet