MCID: SLC006
MIFTS: 53

Silicosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Silicosis

Aliases & Descriptions for Silicosis:

Name: Silicosis 38 12 50 52 42 14 69
Silicotuberculosis 12 69
Chronic Silicosis 50 69
Acute Silicosis 50 69
Pneumoconiosis Due to Silicates 12
Silicotic Fibrosis of Lung 12
Experimental Silicosis 50
Silica Pneumoconiosis 12
Accelerated Silicosis 50

Classifications:



External Ids:

Disease Ontology 12 DOID:10325
ICD10 33 J62 J62.8
ICD9CM 35 502
MeSH 42 D012829
NCIt 47 C3369
UMLS 69 C0037116

Summaries for Silicosis

NIH Rare Diseases : 50 silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure (weeks or months) of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. a cough, weight loss, and fatigue may also be present. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 12/17/2015

MalaCards based summary : Silicosis, also known as silicotuberculosis, is related to tuberculosis and histiocytosis. An important gene associated with Silicosis is FASLG (Fas Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Isoniazid and Rifampin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and lymph node, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and immune system

Disease Ontology : 12 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia : 71 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Related Diseases for Silicosis

Diseases related to Silicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 30.2 ACE CCL2 IL1B TNF
2 histiocytosis 29.3 CXCL8 IL1A IL1B IL1RN TNF
3 anthracosis 11.1
4 interstitial lung disease 10.8
5 lung cancer 10.4
6 intussusception 10.4 IL1B TNF
7 pneumoconiosis due to talc 10.3
8 tau syndrome 10.3 IL1B TNF
9 stocco dos santos syndrome 10.3 IL1B TNF
10 toxic optic neuropathy 10.3 IL1A IL1B
11 nut midline carcinoma 10.3 FAS IL1A
12 oculomotor nerve paralysis 10.3 CXCL8 IL1B
13 twin-to-twin transfusion syndrome 10.3 FAS IL1B TNF
14 common peroneal nerve lesion 10.3 CXCL8 IL1B
15 pseudo-meigs syndrome 10.3 FAS FASLG TNF
16 dextrocardia 10.2 IL1B IL1RN TNF
17 benign neonatal seizures 10.2 IL1B IL1RN TNF
18 cerebellar disease 10.2 IL1A IL1B TNF
19 breast adenomyoepithelioma 10.2 FAS FASLG IL1B
20 mikulicz disease 10.2 IL1A IL1B TNF
21 keratoconus 10.2 IL1B IL1RN TNF
22 amyotrophic lateral sclerosis type 14 10.2 CXCL8 IL1B TNF
23 parkinson disease 11 10.2 CXCL8 IL1B TNF
24 midline interhemispheric variant of holoprosencephaly 10.2 FAS FASLG
25 acquired thrombocytopenia 10.2 CXCL8 IL1B TNF
26 neuropathy 10.2 CXCL8 IL1B TNF
27 ovarian cystic teratoma 10.2 CXCL8 IL1B TNF
28 mental retardation hypotonia skin hyperpigmentation 10.2 IL1A IL1B IL1RN
29 blepharochalasis 10.2 CXCL8 IL1B TNF
30 chordoid meningioma 10.2 CXCL8 IL1B TNF
31 glossitis 10.2 IL1A IL1B IL1RN
32 orthostatic proteinuria 10.2 CXCL8 IL1RN TNF
33 skeletal muscle cancer 10.2 FAS FASLG
34 balkan nephropathy 10.2 CXCL8 IL1B TNF
35 unilateral hypoactive labyrinth 10.2 CXCL8 IL1B TNF
36 colon adenocarcinoma 10.2 CXCL8 IL1B TNF
37 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL1B TGFB1 TNF
38 conjunctival concretion 10.2 CXCL8 IL1B TNF
39 cartilage disease 10.2 FAS TGFB1
40 testicular leydig cell tumor 10.2 IL1A IL1B IL1RN
41 blue toe syndrome 10.2 CXCL8 IL1B TNF
42 pneumoconiosis 10.2
43 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.2 IL1B TGFB1 TNF
44 spondylolysis 10.2 CXCL8 IL1B TNF
45 bilateral parasagittal parieto-occipital polymicrogyria 10.2 TGFB1 TNF
46 keratomalacia 10.2 CXCL8 IL1B TNF
47 fungal gastritis 10.2 CXCL8 IL1B TNF
48 esophagus lymphoma 10.2 CXCL8 SCGB1A1 TNF
49 nephropathy with pretibial epidermolysis bullosa and deafness 10.2 CXCL8 IL1B TNF
50 pyoderma gangrenosum 10.2 CXCL8 IL1B TNF

Comorbidity relations with Silicosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Heart Disease Postinflammatory Pulmonary Fibrosis
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to Silicosis

Symptoms & Phenotypes for Silicosis

GenomeRNAi Phenotypes related to Silicosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 IL1B NLRP3 TGFB1 TNF ACE CXCL8
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 IL1B NLRP3 TGFB1 TNF ACE CXCL8

MGI Mouse Phenotypes related to Silicosis:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.21 SFTPD TGFB1 TNF ACE CCL2 FAS
2 homeostasis/metabolism MP:0005376 10.2 ACE FAS FASLG IL1A IL1B IL1RN
3 hematopoietic system MP:0005397 10.18 ACE FAS FASLG IL1A IL1B IL1RN
4 cardiovascular system MP:0005385 10.1 ACE FAS FASLG IL1A IL1B IL1RN
5 mortality/aging MP:0010768 10.02 ACE FAS FASLG IL1B IL1RN NLRP3
6 integument MP:0010771 10.01 FAS FASLG IL1A IL1B IL1RN NLRP3
7 neoplasm MP:0002006 9.86 ACE FAS FASLG IL1A IL1B SCGB1A1
8 liver/biliary system MP:0005370 9.85 FASLG NLRP3 TGFB1 TNF ACE FAS
9 renal/urinary system MP:0005367 9.63 ACE FAS FASLG NLRP3 SCGB1A1 TGFB1
10 respiratory system MP:0005388 9.43 FAS FASLG SCGB1A1 SFTPD TGFB1 TNF
11 skeleton MP:0005390 9.23 TNF DSG1 FAS FASLG IL1B IL1RN

Drugs & Therapeutics for Silicosis

Drugs for Silicosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isoniazid Approved Phase 3 54-85-3 3767
2
Rifampin Approved Phase 3 13292-46-1 5458213 5381226
3
Rifapentine Approved Phase 3 61379-65-5 6323497
4 Anti-Bacterial Agents Phase 3
5 Antibiotics, Antitubercular Phase 3
6 Anti-Infective Agents Phase 3
7 Antimetabolites Phase 3
8 Antitubercular Agents Phase 3
9 Cytochrome P-450 CYP3A Inducers Phase 3
10 Hypolipidemic Agents Phase 3
11 Lipid Regulating Agents Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 3
13 Mitogens Phase 1, Phase 2
14 Respiratory System Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3
2 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
3 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
4 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
5 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
6 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
7 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
8 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
9 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Recruiting NCT02794701

Search NIH Clinical Center for Silicosis

Cochrane evidence based reviews: silicosis

Genetic Tests for Silicosis

Anatomical Context for Silicosis

MalaCards organs/tissues related to Silicosis:

39
Lung, Bone, Lymph Node, Testes, Neutrophil, T Cells, Kidney

Publications for Silicosis

Articles related to Silicosis:

(show top 50) (show all 641)
id Title Authors Year
1
Plastic bronchitis in a patient with silicosis. ( 28365186 )
2017
2
Infodemiological data concerning silicosis in the USA in the period 2004-2010 correlating with real-world statistical data. ( 28054008 )
2017
3
Genome-wide analysis of aberrantly expressed microRNAs in bronchoalveolar lavage fluid from patients with silicosis. ( 26903263 )
2016
4
Endobronchial Silicosis and Tuberculosis Presenting as the Right Middle Lobe Syndrome. ( 27764010 )
2016
5
Silicosis and silicotuberculosis in India. ( 27843169 )
2016
6
Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-I^1/ROCK1 pathway in silicosis in rat. ( 26785300 )
2016
7
CT-guided aspiration cytology of advanced silicosis and confirmation of the deposited zeolite nano particles through X ray diffraction: A novel approach. ( 26748653 )
2016
8
Global DNA methylation and PTEN hypermethylation alterations in lung tissues from human silicosis. ( 27621875 )
2016
9
Dynamic changes of mononuclear phagocytes in circulating, pulmonary alveolar and interstitial compartments in a mouse model of experimental silicosis. ( 27240636 )
2016
10
Can silicosis explain it all? ( 27650457 )
2016
11
Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis. ( 26789403 )
2016
12
SB203580 inhibits epithelial-mesenchymal transition and pulmonary fibrosis in a rat silicosis model. ( 27480278 )
2016
13
Pneumoconiosis Redux. Coal Workers' Pneumoconiosis and Silicosis Are Still a Problem. ( 26977968 )
2016
14
Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis. ( 27014274 )
2016
15
Leveraging Big Data for Exploring Occupational Diseases-Related Interest at the Level of Scientific Community, Media Coverage and Novel Data Streams: The Example of Silicosis as a Pilot Study. ( 27806115 )
2016
16
Denim production and silicosis. ( 26807688 )
2016
17
Silicosis, tuberculosis time bomb? ( 27601099 )
2016
18
Down-Regulation of miR-19a as a Biomarker for Early Detection of Silicosis. ( 27312312 )
2016
19
A study on silicosis among employees of a silica processing factory in the Central Province of Sri Lanka. ( 27031972 )
2016
20
Proteomic profiling change during the early development of silicosis disease. ( 27076927 )
2016
21
Bronchoalveolar Lavage Fluid microRNA-146a: A Biomarker of Disease Severity and Pulmonary Function in Patients With Silicosis. ( 27158964 )
2016
22
Radiological Evaluation of Artificial Stone Silicosis Outbreak: Emphasizing Findings in Lung Transplant Recipients. ( 27680410 )
2016
23
Effects of bone marrow-derived mesenchymal stem cells on the autophagic activity of alveolar macrophages in a rat model of silicosis. ( 27284351 )
2016
24
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in a rare case of carcinoma stomach with concomitant silicosis. ( 27833322 )
2016
25
Progressive multifocal leukoencephalopathy in a patient with silicosis. ( 27416854 )
2016
26
Effect of Xinjiang Uyghur Vernonia anthelmintica Willd Injection Treatment with Silicosis Fibrosis. ( 27803925 )
2016
27
Tadalafil reduces airway hyperactivity and protects against lung and respiratory airways dysfunction in a rat model of silicosis. ( 27769022 )
2016
28
Computed Tomography and Magnetic Resonance Imaging for Longitudinal Characterization of Lung Structure Changes in a Yucatan Miniature Pig Silicosis Model. ( 26839326 )
2016
29
Biometric monitoring in silicosis to detect early disease and monitor lung injury: not quite there. ( 27995129 )
2016
30
Recurrent Tracheal Stenosis: A Novel Presentation of Silicosis. ( 27388408 )
2016
31
Silica, Silicosis, and Autoimmunity. ( 27014276 )
2016
32
Lung cancer in patients diagnosed with silicosis should be investigated. ( 27330963 )
2016
33
Surveillance for Silicosis - Michigan and New Jersey, 2003-2011. ( 27736836 )
2016
34
Proteomic profiling differences in serum from silicosis and chronic bronchitis patients: a comparative analysis. ( 27076939 )
2016
35
Deadly denim: sandblasting-induced silicosis in the jeans industry. ( 27155769 )
2016
36
Silicosis with Various Clinical Courses in a Tunnel Worker: A Case Report. ( 27517002 )
2016
37
Biometric monitoring in silicosis to detect early disease and monitor lung injury: not quite there. ( 27995130 )
2016
38
A stonemason with accelerated silicosis in the setting of tumour necrosis factor alpha inhibitor therapy. ( 27516887 )
2016
39
Fatal silicosis in a funeral arts' craftsman. ( 27976666 )
2016
40
Cell-Based Therapy for Silicosis. ( 27066079 )
2016
41
Silicosis and renal disease: insights from a case of IgA nephropathy. ( 26423329 )
2015
42
Microscopic polyangiitis associated with pleuropericarditis, pulmonary embolism and pulmonary hemorrhage as a complication of silicosis. ( 26236617 )
2015
43
Ischaemic Cavitation in Conglomerate Silicosis. ( 27164731 )
2015
44
Splenic calcification in a patient with silicosis. ( 25876588 )
2015
45
Lipopolysaccharides may aggravate apoptosis through accumulation of autophagosomes in alveolar macrophages of human silicosis. ( 26553601 )
2015
46
Conspicuous disease: The surveillance of silicosis in South Africa, 1910-1970. ( 26509750 )
2015
47
Association of pulmonary silicosis and systemic sclerosis. ( 25628097 )
2015
48
Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in Nalp3, Caspase-1, and IL-1I^ on the Risk of Silicosis: A Case-Control Study. ( 26496436 )
2015
49
Pulmonary Silicosis Presents with Pleural Effusion. ( 26435716 )
2015
50
Historical and emerging workplaces affected by silica exposure since the 1930 Johannesburg conference on Silicosis, with special reference to construction. ( 26509755 )
2015

Variations for Silicosis

Expression for Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for Silicosis

Pathways related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL2 CXCL8 DSG1 FASLG IL1A IL1B
2
Show member pathways
13.64 CCL2 CXCL8 FAS FASLG IL1A IL1B
3
Show member pathways
13.46 CXCL8 FAS FASLG IL1A IL1B TGFB1
4
Show member pathways
13.39 CCL2 CXCL8 FAS FASLG IL1A IL1B
5
Show member pathways
13.34 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
6
Show member pathways
13.27 CCL2 CXCL8 FAS FASLG IL1A IL1B
7
Show member pathways
12.98 CCL2 CXCL8 IL1A IL1B IL1RN NLRP3
8
Show member pathways
12.83 CXCL8 FAS FASLG IL1A IL1B TGFB1
9
Show member pathways
12.73 CCL2 CXCL8 FAS FASLG IL1A IL1B
10 12.72 FAS FASLG IL1A IL1B TGFB1 TNF
11
Show member pathways
12.66 FAS FASLG IL1A IL1B TNF
12
Show member pathways
12.62 FAS FASLG IL1A IL1B TNF
13
Show member pathways
12.59 ACE CCL2 CXCL8 FAS FASLG IL1B
14
Show member pathways
12.57 IL1A IL1B TGFB1 TNF
15 12.55 CCL2 FAS FASLG IL1B IL1RN TNF
16
Show member pathways
12.44 FAS IL1A IL1B TGFB1 TNF
17
Show member pathways
12.34 CCL2 CXCL8 IL1B TNF
18
Show member pathways
12.31 CCL2 IL1A IL1B IL1RN
19 12.31 FAS FASLG TGFB1 TNF
20
Show member pathways
12.27 FAS FASLG IL1A TNF
21
Show member pathways
12.27 IL1A IL1B TGFB1 TNF
22
Show member pathways
12.27 CXCL8 IL1A IL1B TNF
23 12.24 IL1A IL1B TGFB1 TNF
24 12.19 CXCL8 IL1A IL1B IL1RN TNF
25
Show member pathways
12.17 CXCL8 IL1A IL1B TNF
26
Show member pathways
12.17 CXCL8 FAS FASLG IL1B SFTPD TNF
27 12.11 CCL2 IL1A IL1B TNF
28 12.06 IL1A IL1B TGFB1 TNF
29 12.03 FAS TGFB1 TNF
30 11.98 CCL2 FAS IL1B TNF
31 11.97 CXCL8 IL1A IL1B TGFB1
32
Show member pathways
11.94 IL1B TGFB1 TNF
33 11.92 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
34 11.91 CXCL8 IL1B TGFB1 TNF
35 11.89 IL1A IL1B TNF
36 11.88 CXCL8 IL1B TNF
37 11.83 CXCL8 IL1A IL1B
38
Show member pathways
11.83 FAS FASLG TNF
39 11.79 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
40
Show member pathways
11.77 CXCL8 FASLG TNF
41 11.77 IL1B TGFB1 TNF
42 11.77 CXCL8 IL1A IL1B NLRP3 TNF
43
Show member pathways
11.69 CXCL8 IL1A IL1B TNF
44 11.69 CCL2 CXCL8 IL1A IL1B TGFB1 TNF
45 11.65 CCL2 CXCL8 IL1B TGFB1 TNF
46 11.61 CXCL8 IL1B TNF
47 11.57 CXCL8 FASLG TGFB1
48 11.57 FAS FASLG TNF
49 11.54 IL1B TGFB1 TNF
50 11.54 CCL2 IL1B TNF

GO Terms for Silicosis

Cellular components related to Silicosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ACE CCL2 CXCL8 FASLG IL1A IL1B
2 lysosome GO:0005764 9.62 ACE FASLG IL1B SFTPD
3 external side of plasma membrane GO:0009897 9.46 ACE FAS FASLG TNF
4 extracellular region GO:0005576 9.44 ACE CCL2 CXCL8 FAS FASLG IL1A
5 secretory granule GO:0030141 9.43 IL1B SCGB1A1 TGFB1

Biological processes related to Silicosis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.98 CCL2 IL1B TGFB1 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.91 FAS IL1B TGFB1 TNF
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.89 FAS FASLG TNF
4 positive regulation of angiogenesis GO:0045766 9.88 CXCL8 IL1A IL1B
5 response to organic substance GO:0010033 9.87 SCGB1A1 TGFB1 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 IL1B NLRP3 TGFB1 TNF
7 cellular response to mechanical stimulus GO:0071260 9.85 FAS IL1B TGFB1
8 apoptotic signaling pathway GO:0097190 9.85 FAS FASLG TNF
9 cellular response to lipopolysaccharide GO:0071222 9.85 CCL2 CXCL8 NLRP3 TNF
10 neutrophil chemotaxis GO:0030593 9.83 CCL2 CXCL8 IL1B
11 response to lipopolysaccharide GO:0032496 9.83 CCL2 FAS FASLG IL1B SCGB1A1
12 positive regulation of cell division GO:0051781 9.82 IL1A IL1B TGFB1
13 positive regulation of interleukin-6 production GO:0032755 9.8 IL1A IL1B TNF
14 response to progesterone GO:0032570 9.79 CCL2 DSG1 TGFB1
15 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.78 FAS FASLG NLRP3 TNF
16 negative regulation of T cell proliferation GO:0042130 9.76 SCGB1A1 SFTPD TGFB1
17 cellular response to organic cyclic compound GO:0071407 9.76 CCL2 IL1B TGFB1 TNF
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.75 IL1A IL1B TNF
19 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.73 FAS FASLG TNF
20 positive regulation of histone acetylation GO:0035066 9.72 IL1B TGFB1
21 embryonic digestive tract development GO:0048566 9.72 CXCL8 TNF
22 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
23 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.71 FAS FASLG
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
25 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.71 FAS IL1A IL1B
26 extrinsic apoptotic signaling pathway GO:0097191 9.71 FAS FASLG TGFB1 TNF
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
28 macrophage chemotaxis GO:0048246 9.7 CCL2 SFTPD
29 positive regulation of phagocytosis GO:0050766 9.7 IL1B SFTPD TNF
30 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.69 FAS FASLG
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
32 PERK-mediated unfolded protein response GO:0036499 9.68 CCL2 CXCL8
33 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.68 IL1A IL1B
34 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
35 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.67 IL1A IL1B
36 positive regulation of vascular endothelial growth factor production GO:0010575 9.67 IL1A IL1B TGFB1
37 ectopic germ cell programmed cell death GO:0035234 9.66 IL1A IL1B
38 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
39 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
40 interleukin-1 beta production GO:0032611 9.64 IL1B NLRP3
41 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
42 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.63 IL1A TGFB1
43 positive regulation of mononuclear cell migration GO:0071677 9.63 TGFB1 TNF
44 protein kinase B signaling GO:0043491 9.62 CCL2 IL1B TGFB1 TNF
45 inflammatory cell apoptotic process GO:0006925 9.61 FAS FASLG
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 IL1B TNF
47 fever generation GO:0001660 9.59 IL1A IL1B
48 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 CCL2 IL1B TGFB1 TNF
49 immune response GO:0006955 9.56 CCL2 CXCL8 FAS FASLG IL1A IL1B
50 response to glucocorticoid GO:0051384 9.55 CCL2 FAS IL1RN SCGB1A1 TNF

Molecular functions related to Silicosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 CXCL8 FASLG IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Silicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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