MCID: SLC006
MIFTS: 58

Silicosis malady

Respiratory diseases category

Summaries for Silicosis

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 11/3/2010

MalaCards: Silicosis, also known as silicotuberculosis, is related to tuberculosis and pulmonary fibrosis. An important gene associated with Silicosis is SCGB1A1 (secretoglobin, family 1A, member 1 (uteroglobin)), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds cycloheximide and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and testes, and related mouse phenotypes are skeleton and tumorigenesis.

Disease Ontology:8 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:63 Silicosis, (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Aliases & Classifications for Silicosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

silicosis 8 42 10 44 60
silicotuberculosis 8 60
chronic silicosis 42 60
acute silicosis 42 60
pneumoconiosis due to other silica 8
pneumoconiosis due to silicates 8
pneumoconiosis due to silica 8
silicotic fibrosis of lung 8
silica pneumoconiosis nos 8
experimental silicosis 42
accelerated silicosis 42
silicates 8


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Disease Ontology8 DOID:10325
MeSH34 D012829
ICD9CM27 502
NCIt39 C3369

Related Diseases for Silicosis

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17GeneCards, 18GeneDecks
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Diseases related to Silicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.9IL12B, SFTPD, IFNGR1
2pulmonary fibrosis30.3SFTPD
3pemphigus30.1DSG3, DSG1
4systemic lupus erythematosus30.1FASLG, IL1RN, IL12B, IFNGR1, FAS
5sarcoidosis30.1IL12B, IL1A, IL1RN, SFTPD, IFNGR1, SCGB1A1
6osteoarthritis29.9IL12B, IL1A, ACRV1, IL1RN
7melanoma29.9DSG1, IL1A, EGR1, FAS, FASLG
8adenocarcinoma29.9CLEC3B, DSG3, EGR1, FASLG, FAS, TNFRSF6B
9hepatitis29.8FASLG
10arthritis29.8IL1A, IL1RN
11dermatitis29.8DSG1, DSG3, IL1A
12interstitial lung disease29.8SFTPD, IL1RN, IL1A
13dermatomyositis29.8IL1A, IL1RN, SFTPD
14idiopathic pulmonary fibrosis29.8FASLG, SCGB1A1, SFTPD, IL1RN, IL1A
15lymphopenia29.8FAS, FASLG, IL1RN
16aspergillosis29.8SFTPD
17lung cancer10.7
18pneumoconiosis10.5
19asbestosis10.5
20pulmonary tuberculosis10.3
21pneumothorax10.3
22bronchitis10.1
23anthracosis10.1
24berylliosis10.1
25connective tissue disease10.1
26lupus erythematosus10.1
27elephantiasis10.1
28synovitis10.1
29bagassosis10.0
30lymph node cancer10.0
31pancreatitis10.0
32pneumonia10.0
33inflammatory bowel disease10.0IL1RN
34allergic rhinitis10.0SCGB1A1
35periodontitis10.0IL1A
36rhinitis10.0SCGB1A1
37gingivitis10.0IL1A
38bronchiolitis obliterans10.0SCGB1A1
39sarcoma10.0DSG1
40chorioamnionitis10.0IL1RN
41measles10.0IL12B
42lichen planus10.0DSG3
43thrombocytopenia10.0IL1A
44leishmaniasis10.0IFNGR1
45myeloma10.0FAS, FASLG
46adenoma10.0IL11RA
47cervical cancer10.0IL1A
48pemphigus vegetans10.0DSG1
49influenza10.0SFTPD
50polymyalgia rheumatica10.0IL1RN

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Clinical Features for Silicosis

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Drugs & Therapeutics for Silicosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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32MalaCards
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MalaCards organs/tissues related to Silicosis:

32
Lung, Lymph node, Testes, Bone, T cells, Kidney, Skin, Pancreas, Liver, Smooth muscle, Brain, Eye

Animal Models for Silicosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Silicosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.3FASLG, FAS, IFNGR1
2MP:000200610.2IFNGR1, FASLG, SCGB1A1, IL12B
3MP:00053879.7IL1A, SFTPD, IFNGR1, TNFRSF18, FAS, FASLG
4MP:00053979.7FASLG, FAS, TNFRSF18, IFNGR1, SFTPD, EGR1
5MP:00053849.5IFNGR1, TNFRSF18, FAS, FASLG, EGR1, ZBTB32

Publications for Silicosis

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50PubMed
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Articles related to Silicosis:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Silicosis in sandblasters of shipyard versus silicosis in stone carvers in Brazil: a comparison of imaging findings, lung function variables and cardiopulmonary exercise testing parameters. (22717312)
2012
2
Efficacy of an absorbable polyglycolic acid patch in surgery for pneumothorax due to silicosis. (22394587)
2012
3
Assessment of respiration-related quality of life of Chinese patients with silicosis and its influencing factors using the St. George's Respiratory Questionnaire (SGRQ). (22111757)
2012
4
Biomarkers: A potential prognostic tool for silicosis. (23776317)
2012
5
Silicosis in quartz conglomerate workers. (21211893)
2011
6
Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients. (21329560)
2011
7
Meta-analyses of published epidemiological studies, 1979-2006, point to open causal questions in silica-silicosis-lung cancer research. (21834269)
2011
8
Quality of life, depression and anxiety in young male patients with silicosis due to denim sandblasting. (21740385)
2011
9
Incidence of silicosis in flourmill workers. (22412287)
2011
10
Innate immune processes are sufficient for driving silicosis in mice. (20576854)
2010
11
Three decades of silicosis: disease trends at autopsy in South African gold miners. (20194070)
2010
12
Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. (19568841)
2009
13
Silicosis in lymph nodes: the canary in the miner? (19209037)
2009
14
Silicosis mortality among young adults in the United States, 1968-2004. (18521821)
2008
15
Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis. (17693780)
2007
16
Denim sandblasting and silicosis two new subsequent cases in Turkey. (17401800)
2007
17
Do bullae and emphysema increase risk of pneumothorax in silicosis? (17868470)
2007
18
Silica, silicosis, and lung cancer. (16544735)
2006
19
Mortality in slate workers and silicosis. (16140832)
2005
20
Coming up for air: experts, employers, and workers in campaigns to compensate silicosis sufferers in Britain, 1918-1939. (15981383)
2005
21
Estimating the total number of newly-recognized silicosis cases in the United States. (12874846)
2003
22
Resistance to acute silicosis in senescent rats: role of alveolar macrophages. (14680365)
2003
23
Pulmonary silicosis and systemic lupus erythematosus in men: a report of two cases. (11858360)
2002
24
Silicosis and tuberculosis among South African goldminers--an overview of recent studies and current issues. (11544967)
2001
25
Lymphopenia in occupational pulmonary silicosis with or without autoimmune disease. (11737074)
2001
26
Different distribution of HLA class II alleles in anti-topoisomerase I autoantibody responders between silicosis and systemic sclerosis patients, with a common distinct amino acid sequence in the HLA-DQB1 domain. (11776400)
2001
27
Mast cell basic fibroblast growth factor in silicosis. (10852784)
2000
28
MRI signal characteristics of progressive massive fibrosis in silicosis. (9714391)
1998
29
The immunopathology of siliconosis. History, clinical presentation, and relation to silicosis and the chemistry of silicon and silicone. (9951648)
1998
30
Value of the lymphoblastic transformation in patients with silicosis. (10660971)
1998
31
Elevated soluble Fas/APO-1 (CD95) levels in silicosis patients without clinical symptoms of autoimmune diseases or malignant tumours. (9367417)
1997
32
Silicosis and pulmonary tuberculosis in stone-grinding factories in Saraburi, Thailand. (8868010)
1995
33
Silicosis and lung cancer risk in underground uranium miners. (8138413)
1994
34
Clinical aspects of coal workers' pneumoconiosis and silicosis. (8456347)
1993
35
How silicosis and coal workers' pneumoconiosis develop--a cellular assessment. (8384379)
1993
36
A double-blind placebo-controlled clinical trial of three antituberculosis chemoprophylaxis regimens in patients with silicosis in Hong Kong. Hong Kong Chest Service/Tuberculosis Research Centre, Madras/British Medical Research Council. (1731596)
1992
37
Lung function in relation to silicosis and silica exposure in granite workers. (1330677)
1992
38
Prediction of silicosis and lung cancer in the Australian labor force exposed to silica. (1336621)
1992
39
Effect of native and modified forms of superoxide dismutase and catalase on experimental silicosis in rats. (1476368)
1992
40
Silicosis. (1511553)
1992
41
Lung function in silicosis. (1544686)
1992
42
Silicosis due to inhalation of domestic cleaning powder. (1681390)
1991
43
Thoracic radiographic features of silicosis in 19 horses. (1941758)
1991
44
Factors associated with massive fibrosis in silicosis. (2038729)
1991
45
Recent advances in the pathogenesis and clinical assessment of mineral dust pneumoconioses: asbestosis, silicosis and coal pneumoconiosis. (2691279)
1989
46
Pulmonary inflammation and fibrosis in a murine model of asbestosis and silicosis. Possible role of tumor necrosis factor. (2753523)
1989
47
Silicosis in women. Experience from the Swedish Pneumoconiosis Register. (4009304)
1985
48
The effect of small amounts of aluminium, carbon and carborundum on the development of silicosis and asbestosis. (4338194)
1972
49
Experimental endogenous lipid pneumonia and silicosis. (4311004)
1969
50
Berylliosis and silicosis. (14841360)
1951

Genetic Variations for Silicosis

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Expression for genes affiliated with Silicosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 51QIAGEN, 55SinoBiological
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Pathways related to Silicosis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4FAS, FASLG
210.4FASLG, FAS
310.3DSG1, DSG3
410.3IL12B, FASLG, FAS
5
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10.3FASLG, FAS, TNFRSF6B
6
Apoptosis and survival Apoptotic TNF-family pathways
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10.3TNFRSF18, FAS, FASLG
710.3TNFRSF18, FASLG, EGR1
8
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10.3IL12B, IL11RA, TNFRSF18
9
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10.3IL12B, FASLG, FAS, IFNGR1
10
Apoptosis and survival Caspase cascade
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10.3IL1A, FASLG, FAS, TNFRSF6B
11
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10.2IL1A, IL1RN, EGR1, IFNGR1
12
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10.2TNFRSF6B, TNFRSF18, FAS, FASLG
13
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10.2FASLG, FAS, TNFRSF18, TNFRSF6B
14
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10.2IFNGR1, FAS, FASLG, IL12B, IL1A
15
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10.2IFNGR1, FAS, FASLG, IL12B, IL1A
16
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10.2IFNGR1, FAS, FASLG, EGR1, IGLV@
17
Immune response Bacterial infections in normal airways
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10.2IL1A, SFTPD, IFNGR1, FAS, FASLG, IL1RN
18
Hide members
10.0IFNGR1, TNFRSF6B, TNFRSF18, FAS, FASLG, IL11RA

Compounds for genes affiliated with Silicosis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Silicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8FASLG
2indomethacin44 59 28 1113.8EGR1
3endotoxin4410.8FASLG, SCGB1A1
42-chloroethyl ethyl sulfide4410.8IL1A, IL1RN
5prednisolone44 28 1112.7SFTPD, DSG3
6imiquimod44 28 59 1113.7FASLG, IL12B, IL1A
7tetracycline44 1111.7FAS, FASLG, SCGB1A1, IL1A
8(glc)44410.7FAS, FASLG
9cellulose triacetate4410.7IL1RN, IL1A
103-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4410.7FAS, FASLG, IL1A
11sulfasalazine44 28 49 1113.7IL12B, IL1RN, IL1A
12manganese superoxide4410.7FASLG, EGR1, IL1RN, IL1A
13rantes4410.7IL1A, IL12B, FASLG, FAS
14vitamin a44 11 2412.7IL1A, FAS
15morphine44 49 28 1113.7IL1A, IL1RN, FASLG, FAS
16gp 1304410.7IL11RA, SCGB1A1, FAS, IFNGR1
17il 104410.7IL1A, IL1RN, IL12B
18hyaluronic acid44 2411.7FASLG, SCGB1A1, IL1RN, IL1A
19tgf beta14410.7IL1RN, EGR1, FASLG, FAS
20agarose4410.7IL1RN, FASLG, FAS, SFTPD
21epinephrine44 11 2412.6FAS, FASLG, EGR1, IL1RN, IL1A
22ionomycin4410.6IL1A, EGR1, FASLG, FAS
23calyculin a44 59 1112.6FAS, FASLG, EGR1
24pentoxifylline44 1111.6IL1A, IL1RN, IL12B
25paclitaxel44 49 1112.6FAS, FASLG, EGR1, IL12B, IL1A
26serine4410.6DSG3, DSG1, IL1RN, IL1A
27atpo44 2811.6FASLG, FAS
28sb 20358044 5911.6FAS, FASLG, EGR1, IL12B, IL1RN, IL1A
29ivig4410.6IL1A, IL1RN, DSG1, DSG3, FASLG, FAS
30ag 14784410.6EGR1, FASLG, FAS
31cyclosporin a44 28 5912.6FAS, FASLG, EGR1, IL1RN, IL1A
32iron44 2411.6IFNGR1, FASLG, SCGB1A1, EGR1, IL1RN
33toxin a4410.5DSG1, DSG3
34ribonucleic acid4410.5FAS, EGR1, IL1RN, IL1A
35ascorbic acid44 2411.5FAS, FASLG, IL1RN, IL1A
36dexamethasone44 49 28 1113.5SFTPD, FAS, FASLG, EGR1, CLEC3B, IL1RN
37thymidine44 2411.5SFTPD, FAS, FASLG, EGR1, IL1A
38nitric oxide44 11 2412.5SFTPD, FAS, FASLG, SCGB1A1, EGR1, IL12B
39heparin44 28 11 2413.5FAS, FASLG, CLEC3B, IL1RN, IL1A
40phosphatidylinositol4410.5SFTPD, TNFRSF6B, FAS, FASLG, SCGB1A1, EGR1
41oxygen44 2411.5SFTPD, IFNGR1, FAS, SCGB1A1, EGR1, CLEC3B
42anisomycin44 1111.5FAS, FASLG, EGR1
43h2o24410.4IL1RN, FASLG
44retinoic acid44 2411.3FAS, FASLG, EGR1, DSG1, IL1RN, IL1A
45progesterone44 59 28 11 2414.3IL1A, IL1RN, EGR1, SCGB1A1, FASLG
46polysaccharide4410.3SFTPD, FAS, FASLG, CLEC3B
47calcium44 49 11 2413.3SFTPD, FASLG, SCGB1A1, EGR1, DSG3, DSG1
48acetylcholine44 49 28 11 2414.2IL1A, DSG1, DSG3, EGR1
49vitamin d4410.2FAS, IL12B, IL1RN, IL1A
50testosterone44 59 11 2412.9FAS, FASLG, EGR1, IL1RN, IL1A

GO Terms for genes affiliated with Silicosis

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16Gene Ontology
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Cellular components related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0TNFRSF18, FAS, FASLG, CLEC3B, IL1A, LRG1
2extracellular spaceGO:0056159.6LRG1, SFTPD, TNFRSF6B, FASLG, SCGB1A1, CLEC3B

Biological processes related to Silicosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.6FASLG, FAS
2cellular response to hyperoxiaGO:07145510.5EGR1, FAS
3response to glucocorticoid stimulusGO:05138410.4FAS, SCGB1A1, IL1RN
4apoptotic processGO:00691510.3TNFRSF6B, FAS, FASLG, DSG3, DSG1, IL1A
5regulation of cytokine productionGO:00181710.2ZBTB32, SFTPD
6negative regulation of apoptotic processGO:04306610.2TNFRSF6B, TNFRSF18, FAS, EGR1, IL1RN
7signal transductionGO:00716510.1TNFRSF18, FAS, FASLG, SCGB1A1, IL11RA, IFNGR1
8regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.1FASLG, FAS

Molecular functions related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.4IL1A, IL1RN

Products for genes affiliated with Silicosis

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Sources for Silicosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet