MCID: SLC006
MIFTS: 58

Silicosis malady

Rare diseases, Respiratory diseases categories
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Summaries for Silicosis

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8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. there are three types of silicosis: simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20 years) to low amounts of silica dust. simple chronic silicosis may cause people to have difficulty breathing.  accelerated silicosis occurs after 5 to 15 years of exposure of higher levels of silica. swelling of the lungs and other symptoms occur faster in this type of silicosis than in the simple chronic form.  acute silicosis results from short-term exposure of large amounts of silica. the lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. acute silicosis progresses rapidly and can be fatal within months.  people who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition. last updated: 11/3/2010

MalaCards: Silicosis, also known as silicotuberculosis, is related to systemic lupus erythematosus and sarcoidosis. An important gene associated with Silicosis is FASLG (Fas ligand (TNF superfamily, member 6)), and among its related pathways are Signal transduction JNK pathway and FAS (CD95) signaling pathway. The compounds (glc)4 and atpo have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and testes, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Disease Ontology:8 A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles.

Wikipedia:65 Silicosis (previously miner\'s phthisis, grinder\'s asthma, potter\'s rot and other occupation-related... more...

Aliases & Classifications for Silicosis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 40NCIt, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

silicosis 8 43 10 45 62
silicotuberculosis 8 62
chronic silicosis 43 62
acute silicosis 43 62
pneumoconiosis due to other silica 8
pneumoconiosis due to silicates 8
pneumoconiosis due to silica 8
silicotic fibrosis of lung 8
silica pneumoconiosis nos 8
experimental silicosis 43
accelerated silicosis 43
silicates 8


External Ids:

Disease Ontology8 DOID:10325
MeSH35 D012829
NCIt40 C3369
ICD9CM27 502

Related Diseases for Silicosis

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17GeneCards, 18GeneDecks
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Diseases related to Silicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.2FAS, FASLG, IL1RN
2sarcoidosis30.2SCGB1A1, IL1RN, IL1A
3pemphigus vulgaris30.2DSG1, IL1A
4hepatitis29.9FASLG, FAS
5interstitial lung disease29.9IL1RN, IL1A
6dermatomyositis29.9IL1RN, IL1A
7lymphopenia29.9IL1RN, FASLG, FAS
8polymyositis29.9IL1A, IL1RN
9dermatitis29.9IL1A, DSG1
10idiopathic pulmonary fibrosis29.8IL1A, IL1RN, FASLG, SCGB1A1
11lung cancer10.7
12tuberculosis10.6
13pneumoconiosis10.6
14asbestosis10.6
15pulmonary tuberculosis10.3
16pneumothorax10.3
17spontaneous pneumothorax10.3
18pulmonary function10.2
19pemphigus10.1
20bronchitis10.1
21berylliosis10.1
22anthracosis10.1
23connective tissue disease10.1
24lupus erythematosus10.1
25uveitis10.1IL1A
26vogt-koyanagi-harada disease10.1FAS, FASLG
27toxic epidermal necrolysis10.1FAS, FASLG
28lymphomatoid papulosis10.1FASLG, FAS
29stevens-johnson syndrome10.1FAS, FASLG
30autoimmune lymphoproliferative syndrome10.1FASLG, FAS
31aplastic anemia10.1FAS, FASLG
32acute graft versus host disease10.1IL1RN, FASLG
33bagassosis10.1
34pancreatitis10.1
35pneumonia10.1
36blindness10.1
37cor pulmonale10.1
38viral hepatitis10.1FAS, FASLG
39type 1 diabetes mellitus10.1IL1RN, FASLG
40autoimmune thyroiditis10.1FAS, FASLG
41graft versus host disease10.1FAS, FASLG
42bronchopulmonary dysplasia10.1IL1RN, SCGB1A1
43esophageal cancer10.0FASLG, DSG1
44newborn respiratory distress syndrome10.0IL1RN, SCGB1A1
45alopecia areata10.0IL1RN, IL1A
46sjogren's syndrome10.0FAS, FASLG
47cerebral malaria10.0IL1A, IL1RN
48juvenile rheumatoid arthritis10.0IL1A, IL1RN
49nephritis10.0IL1RN, SCGB1A1
50periodontitis10.0IL1RN, IL1A

Graphical network of the top 20 diseases related to Silicosis:



Diseases related to silicosis

Symptoms for Silicosis

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Drugs & Therapeutics for Silicosis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Silicosis

Search NIH Clinical Center for Silicosis

Genetic Tests for Silicosis

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Anatomical Context for Silicosis

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33MalaCards
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MalaCards organs/tissues related to Silicosis:

33
Lung, Lymph node, Testes, Bone, T cells, Kidney, Smooth muscle, Eye, Skin, Brain, Liver, Pancreas

Animal Models for Silicosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Silicosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5SCGB1A1, FAS, FASLG, IL1A
2MP:00053978.0IL1A, IL11RA, IL1RN, FASLG, FAS
3MP:00053857.7FAS, FASLG, IL1RN, IL11RA, IL1A
4MP:00053877.6IL1A, IL11RA, IL1RN, FASLG, FAS, SCGB1A1

Publications for Silicosis

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52PubMed
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Articles related to Silicosis:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Cryptococcosis, silicosis, and tuberculous pseudotumor in the same pulmonary lobe. (24310636)
2013
2
Erasmus syndrome: silicosis and systemic sclerosis. (24051915)
2013
3
Silicosis in sandblasters of shipyard versus silicosis in stone carvers in Brazil: a comparison of imaging findings, lung function variables and cardiopulmonary exercise testing parameters. (22717312)
2012
4
Respirable crystalline silica exposure-response evaluation of silicosis morbidity and lung cancer mortality in the German porcelain industry cohort. (21346639)
2011
5
Silicotuberculosis and silicosis as occupational diseases: report of two cases. (21980669)
2011
6
Silicosis in automobile foundry workers: a 29-year cohort study. (20514987)
2010
7
A brief review of silicosis in the United States. (20523881)
2010
8
Silicosis among agate workers at Shakarpur: An analysis of clinic-based data. (21139719)
2010
9
Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases. (19568841)
2009
10
FDG PET findings in a case with acute pulmonary silicosis. (19866335)
2009
11
Effect of silicosis alveolar macrophages on expression of c-myc in human embryo lung fibroblast in vitro]. (19358757)
2008
12
The value of high resolution computed tomography in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to radiography. (18667790)
2008
13
Surveillance for early silicosis in high altitude miners using pulse oximetry. (18686718)
2008
14
Silicosis caused by sandblasting of jeans in Turkey: a report of two concomitant cases. (16096363)
2005
15
The recognition of silicosis: labor unions and physicians in the Chilean copper industry, 1930s-1960s. (16327085)
2005
16
Progressive massive fibrosis secondary to pulmonary silicosis appearance on F-18 fluorodeoxyglucose PET/CT. (15483503)
2004
17
Tracheobronchopathia osteochondroplastica in a patient with silicosis: CT, bronchoscopy, and pathology findings. (15538154)
2004
18
Silicosis prevalence and exposure-response relations in South African goldminers. (15377766)
2004
19
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients. (14514471)
2003
20
Silicosis in 76 men: qualitative and quantitative CT evaluation--clinical-radiologic correlation study. (12954899)
2003
21
The long and winding road from silica exposure to silicosis and other health effects. (12598660)
2003
22
The histogenesis of experimental silicosis. I--Methods for the histological evaluation of experimentally induced dust lesions. (2). 1960. (11899939)
2001
23
Silicosis and tuberculosis among South African goldminers--an overview of recent studies and current issues. (11544967)
2001
24
Accelerated silicosis in workers exposed to agate dust in Guangzhou, China. (11439400)
2001
25
Cohort mortality study of North American industrial sand workers. II. Case-referent analysis of lung cancer and silicosis deaths. (11295143)
2001
26
IgG subclass responses in experimental silicosis. (11570675)
2001
27
Mast cell basic fibroblast growth factor in silicosis. (10852784)
2000
28
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis. (10905501)
2000
29
Centennial photo page. Silicosis and a few of the other pneumoconiosies: observations on certain aspects of the problem, with emphasis on the role of the radiologist. 1958. (10915663)
2000
30
Pemphigus foliaceus associated with silicosis. (10951170)
2000
31
Cost-effectiveness of hospital discharge records for reaching selected endpoints in the surveillance of silicosis. (9787853)
1998
32
Persistent overexpression of interleukin-1beta and tumor necrosis factor-alpha in murine silicosis. (9546746)
1998
33
Silicosis deaths among young adults--United States, 1968-1994. (9583901)
1998
34
Systemic lupus erythematosus arising in a patient with chronic silicosis. (9032822)
1997
35
Photosensitivity and autoantibodies to Sm, Ro, and La in a patient with silicosis. (8876307)
1996
36
Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: studies of transforming growth factor beta expression. (8621163)
1996
37
Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography. (8800444)
1996
38
Silicosis in Brazilian pit diggers: relationship between dust exposure and radiologic findings. (7747743)
1995
39
Mortality among persons with silicosis reported to disease surveillance systems in Michigan and New Jersey in the United States. (8929696)
1995
40
The epidemiology of tuberculosis in gold miners with silicosis. (7952577)
1994
41
Cor pulmonale and silicosis: a necropsy based case-control study. (8329320)
1993
42
Correlation between radiological and pathological diagnosis of silicosis: an autopsy population based study. (8250062)
1993
43
Silicosis surveillance--Michigan, New Jersey, Ohio, and Wisconsin, 1987-1990. (8232180)
1993
44
Silicosis following employment in the manufacture of silica flour and industrial sand. (8366396)
1993
45
Effect of prednisolone treatment in chronic silicosis. (2008993)
1991
46
Silicosis due to inhalation of domestic cleaning powder. (1681390)
1991
47
Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma. (2117968)
1990
48
Pneumoconiosis (silicosis) in the confectionery industry. (2345825)
1990
49
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
50
Berylliosis and silicosis. (14841360)
1951

Variations for Silicosis

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Expression for genes affiliated with Silicosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Silicosis

Search GEO for disease gene expression data for Silicosis.

Pathways for genes affiliated with Silicosis

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 54R&D Systems, 55Reactome, 53QIAGEN, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Silicosis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7FASLG, FAS
2
Show member pathways
TRAIL signaling pathway38
9.7FASLG, FAS
39.7FASLG, FAS
4
Show member pathways
9.7FASLG, FAS
5
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.7FAS, FASLG
6
Show member pathways
9.7FAS, FASLG
79.5FASLG, IL1A
8
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.3IL1A, IL1RN
99.3IL11RA, IL1A
10
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.3FASLG, FAS, DSG1
11
Show member pathways
9.1FAS, IL1A, FASLG
12
Show member pathways
MAPK signaling pathway38
9.1FAS, IL1A, FASLG
13
Show member pathways
9.1FASLG, IL1A, FAS
14
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.1IL1A, FASLG, FAS
15
Show member pathways
9.1IL1A, FASLG, FAS
16
Show member pathways
9.1IL1A, FASLG, FAS
17
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.9FASLG, TNFRSF6B, FAS
18
Show member pathways
8.9FAS, TNFRSF6B, FASLG
19
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.9FASLG, TNFRSF6B, FAS
208.9TNFRSF6B, FAS, FASLG
21
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
8.2IL1A, FASLG, FAS, TNFRSF6B
22
Show member pathways
7.7IL11RA, FAS, FASLG, IL1A, TNFRSF6B

Compounds for genes affiliated with Silicosis

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45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 51PharmGKB, 24HMDB
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Compounds related to Silicosis according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1(glc)44510.1FAS, FASLG
2atpo29 4511.0FAS, FASLG
3teniposide45 1110.9FASLG, FAS
4concanamycin a45 6110.8FAS, FASLG
52-chloroethyl ethyl sulfide459.8IL1A, IL1RN
6polysulfone459.8FASLG, IL1RN
7cellulose triacetate459.7IL1RN, IL1A
8imiquimod45 61 29 1112.7FASLG, IL1A
9gold sodium thiomalate459.6IL1A, IL1RN
10bromodeoxyuridine459.6SCGB1A1, FASLG, IL1RN
11cellulose acetate459.5FASLG, IL1RN
12tgf beta1459.5FASLG, FAS, IL1RN
133-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.5IL1A, FASLG, FAS
14agarose459.5FASLG, FAS, IL1RN
15gp 130459.5SCGB1A1, FAS, IL11RA
16camptothecin45 61 1111.4FAS, FASLG, IL1A
17mg 13245 6110.4FAS, IL1A, FASLG
18manganese superoxide459.4IL1RN, FASLG, IL1A
19ionomycin459.3FASLG, FAS, IL1A
20polymyxin b459.3IL1RN, IL1A
21simvastatin45 51 61 29 24 1114.3IL1A, IL1RN, FASLG
22tetracycline45 1110.1IL1A, FAS, SCGB1A1, FASLG
23ribonucleic acid459.1IL1A, IL1RN, FAS
24rapamycin459.1FASLG, IL1A, FAS
25aspartate459.0FASLG, SCGB1A1, FAS, IL1A
26hyaluronic acid45 2410.0IL1A, IL1RN, FASLG, SCGB1A1
27endotoxin459.0IL1A, SCGB1A1, FASLG, IL1RN
28morphine45 51 29 1112.0FAS, FASLG, IL1A, IL1RN
29rantes459.0IL1RN, IL1A, FASLG, FAS
30epinephrine45 24 1111.0IL1RN, IL1A, FAS, FASLG
31ascorbic acid45 2410.0IL1RN, FAS, IL1A, FASLG
32indomethacin45 29 61 1112.0FAS, FASLG, IL1A, IL1RN
33sb 20358045 619.9FAS, FASLG, IL1RN, IL1A
34vitamin d458.9FAS, IL1A, IL1RN
35cyclosporin a45 29 6110.9IL1A, FASLG, IL1RN, FAS
36progesterone45 29 61 24 1112.9IL1RN, FASLG, SCGB1A1, IL1A
37heparin45 29 24 1111.9IL1RN, FASLG, FAS, IL1A
38vitamin a45 24 1110.9IL1A, IL1RN, SCGB1A1, FAS
39cycloheximide458.9IL1RN, IL1A, FASLG, FAS
40creatinine458.9IL1A, FAS, SCGB1A1, IL1RN
41h2o2458.8FASLG, IL1RN, IL1A, FAS
42testosterone45 61 24 1111.8FASLG, FAS, IL1RN, IL1A
43dexamethasone45 51 29 1111.8FAS, FASLG, IL1A, IL1RN
44vegf458.8IL1RN, FAS, FASLG, IL1A
45paclitaxel45 51 1110.8FASLG, FAS, IL1A
46ivig458.6FASLG, FAS, DSG1, IL1A, IL1RN
47retinoic acid45 249.6IL1A, IL1RN, FASLG, DSG1, FAS
48nitric oxide45 24 1110.5FASLG, SCGB1A1, IL1A, IL1RN, FAS
49serine458.4IL1RN, IL1A, FASLG, FAS, DSG1
50phosphatidylinositol458.3IL1RN, SCGB1A1, FAS, FASLG, TNFRSF6B

GO Terms for genes affiliated with Silicosis

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16Gene Ontology
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Cellular components related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.8IL1A, IL1RN, FASLG, SCGB1A1, TNFRSF6B

Biological processes related to Silicosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.0FAS, FASLG
2necroptotic signaling pathwayGO:0975279.9FASLG, FAS
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.9FASLG, FAS
4extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.8FASLG, FAS
5extrinsic apoptotic signaling pathwayGO:0971919.8FASLG, FAS
6fever generationGO:0016609.6IL1A, IL1RN
7female pregnancyGO:0075659.5IL1RN, SCGB1A1
8extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5IL1A, FAS
9response to lipopolysaccharideGO:0324969.4SCGB1A1, FASLG, IL1RN
10activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.4FASLG, FAS
11response to glucocorticoidGO:0513849.3SCGB1A1, FAS, IL1RN
12immune responseGO:0069559.0FASLG, IL1RN, IL1A
13signal transductionGO:0071658.9SCGB1A1, FAS, FASLG, IL11RA
14negative regulation of apoptotic processGO:0430668.6IL1RN, FAS, TNFRSF6B
15apoptotic processGO:0069158.1IL1A, FASLG, FAS, DSG1, TNFRSF6B

Molecular functions related to Silicosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.3IL1A, IL1RN

Products for genes affiliated with Silicosis

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  • Antibodies
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Sources for Silicosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet