Silver-russell Syndrome malady

Genetics Home Reference: Russell-Silver syndrome is a growth disorder characterized by slow growth before and after birth. Babies with this condition have a low birth weight and often fail to grow and gain weight at the expected rate (failure to thrive). Head growth is normal, however, so the head may appear unusually large compared to the rest of the body. Affected children are thin and have poor appetites, and some develop low blood sugar (hypoglycemia) as a result of feeding difficulties. Adults with Russell-Silver syndrome are short; the average height for affected males is about 151 centimeters (4 feet, 11 inches) and the average height for affected females is about 140 centimeters (4 feet, 7 inches).¹⁷

MalaCards: Silver-russell Syndrome, also known as russell-silver syndrome, is related to wilms tumor 2 and short stature. An important gene associated with Silver-russell Syndrome is CSH1 (chorionic somatomammotropin hormone 1 (placental lactogen)), and among its related pathways are JNK Pathway and Caspase Cascade. The compounds rsai and ethylenediaminetetraacetate have been mentioned in the context of this disorder. Affiliated tissues include placenta, and related mouse phenotypes are limbs/digits/tail and liver/biliary system.

NIH Rare Diseases: Russell-Silver syndrome is a disorder present at birth that involves poor growth, low birth weight, short height, and differences in the size of the two sides of the body. The genetic causes of this syndrome are complex. The disorder often results from the abnormal regulation of certain genes that control growth. Research has focused on genes located in particular regions of chromosome 7 and chromosome 11. Most cases of the syndrome are not inherited from an affected parent, but occur sporadically (i.e., by chance).³⁰

OMIM: 180860

GeneReviews summary for rss

Aliases & Descriptions:

silver-russell syndrome 6 7 15 30 17 8 33 russell-silver syndrome 15 30 16 17 43 silver-russell dwarfism 30 17

silver russell dwarfism 6 rss 17 srs 17

Diseases related to silver-russell syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 185)

id	Related Disease	Score	Top Affiliating Genes
1	wilms tumor 2	30.2	RSS, H19
2	short stature	28.8	CSH1, COL1A2, IGF1, IGFBP3, IGF2, IGF1R
3	beckwith-wiedemann syndrome	28.5	GRB10, MEST, CDKN1C, ZFP57, WDR20, IGF1R
4	acromegaly	28.3	IGF1, IGFBP3, IGF2, IGFBP1
5	twinning	28.1	H19, IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
6	adrenocortical carcinoma	26.8	H19, IGF2, IGF1R, CDKN1C
7	wilms tumor	26.1	H19, EGFR, RSS, CTCF, IGF1, IGFBP3
8	hypertension	26.0	CSH1, EGFR, COL1A2, IGF1, IGFBP3, IGF2
9	rhabdomyosarcoma	24.8	H19, EGFR, IGF1, IGF2, IGF1R, IRS1
10	pancreatic carcinoma	24.5	EGFR, IGF1, IGF2, IGF1R, GRB2, GRAP2
11	pancreatic cancer	24.4	H19, EGFR, IGF1, IGFBP3, IGF2BP3, IGF2
12	osteoporosis	24.3	COL1A2, IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
13	breast cancer	24.1	IGF2BP3, IGFBP3, IGF1, SUDS3, CTCF, COPG2
14	squamous cell carcinoma	23.9	H19, TGM1, EGFR, CTCF, IGF1R, IGFBP1
15	pancreatitis	23.7	IGF1, EGFR, CPA1, CPA2, CPA4, CPA5
16	hypoxia	22.8	H19, EGFR, COL1A2, IGF1, IGFBP3, IGF2BP3
17	cervicitis	22.8	IGF1, EGFR, TGM1, DNMT3L, H19, IGFBP3
18	ovarian cancer	22.3	H19, CPA1, DNMT3L, EGFR, CTCF, IGF1
19	adenocarcinoma	22.1	H19, EGFR, COL1A2, IGF1, IGFBP3, IGF2BP3
20	adenoma	21.8	H19, EGFR, TNS3, IGF1, IGFBP3, IGF2
21	carcinoma	21.2	IGFBP3, IGF1, TNS3, CTCF, COL1A2, EGFR
22	leukemia	20.9	IGF2, IGF2BP3, IGFBP3, IGF1, CTCF, EGFR
23	embryonal cancer	13.7	IGF2, H19
24	potter's syndrome	13.6	IGF2, GRAP2
25	hemihypertrophy	13.6	H19, IGF2, CDKN1C
26	gestational trophoblastic neoplasm	13.5	H19, IGF2, CDKN1C
27	isolated growth hormone deficiency, type ia	13.4	IGF1, CSH1
28	adrenal adenoma	13.3	H19, IGF2, GRB2, CDKN1C
29	panhypopituitarism	13.2	IGF1, IGF2, IGFBP1
30	spastic paraplegia 17	13.1	H19, C7orf10, RSS, IGF2, GRB10
31	premature ovarian failure	13.0	IGFBP1, IGF2, IGF1, H19
32	kidney clear cell sarcoma	12.9	H19, EGFR, IGF2
33	ring chromosome 15	12.9	IGF1R, IGF1
34	intrauterine and postnatal growth retardation	12.9	IGF1R, IGF2, IGF1
35	down syndrome	12.9	CDKN1C, IGF1R, CTCF, H19
36	skeletal muscle regeneration	12.8	IGF1, IGF2, IGF1R
37	large cell carcinoma	12.8	EGFR, IGF1, IGF2
38	costello syndrome	12.8	IGF1, IGFBP3, IGF2
39	hyperinsulinemic hypoglycemia	12.8	IGF1, IGF2, IGF1R
40	growth disorders	12.7	H19, IGF1, IGFBP3, IGF2
41	bannayan-riley-ruvalcaba syndrome	12.7	H19, IGF1, IGF2, IRS1
42	osteopenia/osteoporosis	12.7	COL1A2, IGF1, IGFBP3
43	anovulation	12.6	IGF1, IGFBP3, IGFBP1
44	acid-labile subunit	12.6	IGF1, IGFBP3, IGF2, IGFBP1
45	laron syndrome	12.6	IGF1, IGFBP3, IGF2, IGFBP1
46	turner syndrome	12.6	IGF1, IGFBP3, IGFBP1
47	female breast cancer	12.6	IGF1, IGFBP3, IGF2, IGFBP1
48	choriocarcinoma	12.6	H19, CSH1, IGF1, IGF2, IRS1, CDKN1C
49	protein-energy malnutrition	12.5	IGF1, IGFBP3, IGFBP1
50	gigantism	12.5	CDKN1C, IGF2, IGFBP3, IGF1, H19

Clinical features from OMIM: 180860

Approved drugs:

Drug clinical trials:

Genetic tests related to silver-russell syndrome:

id	Genetic test	Affiliating Genes
1	Silver-russell Syndrome clinical/research	IGF2, H19

MalaCards organs/tissues related to silver-russell syndrome:

²²

MGI Mouse Phenotypes related to silver-russell syndrome:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail phenotype	MP:0005371	8.3	H19, EGFR, COL1A2, IGF2, IGF1R, IRS1
2	liver/biliary system phenotype	MP:0005370	7.7	EGFR, IGFBP3, IGF2, IGF1R, IGFBP1, GRB14
3	skeleton phenotype	MP:0005390	7.1	H19, EGFR, COL1A2, TNS3, IGF1, IGF2
4	muscle phenotype	MP:0005369	7.1	IGFBP3, IGF1, COL1A2, EGFR, H19, IGF2
5	cardiovascular system phenotype	MP:0005385	6.7	IGF2, IGF1, COL1A2, EGFR, DNMT3L, H19
6	growth/size phenotype	MP:0005378	5.8	IGFBP3, IGF1, TNS3, COL1A2, EGFR, TGM1
7	immune system phenotype	MP:0005387	5.6	IGF1R, IGF2, IGF1, TNS3, CTCF, EGFR
8	mortality/aging	MP:0010768	5.4	TNS3, SUDS3, CTCF, COL1A2, EGFR, TGM1
9	cellular phenotype	MP:0005384	5.3	SGCE, IGF2, IGF1, TNS3, SUDS3, CTCF

Articles related to silver-russell syndrome:

(show all 39)

id	Title	Authors	Year	Affiliating Genes
1	Deletions and rearrangements of the H19/IGF2 enhancer region in patients with Silver-Russell syndrome and growth retardation. (21278389)	GrA... Mackay D.J.	2011	IGF2
2	Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome. (21282187)	Nativio R.... Murrell A.	2011	IGF2, H19
3	MBD3 mutations are not responsible for ICR1 hypomethy lation in Silver-Russell syndrome. (20004753)	Bachmann N.... Eggermann T.	2010	MBD3
4	Clinically distinct epigenetic subgroups in Silver-Russell syndrome: the degree of H19 hypomethylation associates with phenotype severity and genital and skeletal anomalies. (19017756)	Bruce S.... Lipsanen-Nyman M.	2009	H19
5	Epigenetic mutations of the imprinted IGF2-H19 domain in Silver- Russell syndrome (SRS): results from a large cohort of patients with SRS and SRS-like phenotypes. (19066168)	Bartholdi D.... Baumer A.	2009	IGF2, H19
6	Molecular and clinical findings and their correlations in Silver-Russell syndrome: implications for a positive role of IGF2 in growth determination and differential imprinting regulation of the IGF2-H19 domain in bodies and placentas. (18607558)	Yamazawa K.... Ogata T.	2008	IGF2
7	Monozygotic female twins discordant for Silver-Russell syndrome and hypomethylation of the H19-DMR. (18709478)	Yamazawa K.... Ogata T.	2008	H19
8	Are H19 variants associated with Silver-Russell syndrome? (19209620)	SchAPnherr N.... Eggermann T.	2008	H19
9	IGF2/H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia. (18159214)	Zeschnigk M.... Horsthemke B.	2008	IGF2, H19
10	Maternally inherited duplication of chromosome 7, dup(7)(p11.2p12), associated with mild cognitive deficit without features of Silver-Russell syndrome. (17551927)	Leach N.T.... Weremowicz S.	2007	GRB10
11	Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST. (17450433)	Kagami M.... Ogata T.	2007	MEST
12	Hypomethylation in the 11p15 telomeric imprinting domain in a patient with Silver-Russell syndrome with a CSH1 deletion (17q24) renders a functional role of this alteration unlikely. (17400796)	Eggermann T.... Wollmann H.	2007	CSH1
13	Hypomethylation of the H19 gene causes not only Silver-Russell syndrome (SRS) but also isolated asymmetry or an SRS-like phenotype. (16532391)	Bliek J.... Mannens M.	2006	H19
14	Searching for genomic variants in IGF2 and CDKN1C in Silver-Russell syndrome patients. (15234339)	Obermann C.... Eggermann T.	2004	IGF2, CDKN1C
15	Searching for genomic variants in the MESTIT1 transcript in Silver-Russell syndrome patients. (12746419)	Meyer E.... Eggermann T.	2003	MESTIT1
16	The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver- Russell syndrome. (12676894)	Bentley L.... Moore G.E.	2003	CPA1, MEST, CPA4
17	Characterization of genomic variants in CSH1 and GH2, two candidate genes for Silver-Russell syndrome in 17q24-q25. (14642004)	Prager S.... Eggermann T.	2003	CSH1
18	Screening for insulin-like growth factor-I receptor mutations in patients with Silver-Russell syndrome. (12387515)	Binder G.... Ranke M.B.	2002	IGF1
19	Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q. (11897833)	Hitchins M.P.... Moore G.E.	2002	GRB2, CSH1, GRB7
20	Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome. (12161597)	Monk D.... Moore G.E.	2002	IGF2BP3
21	IRS1 and GRB2 as members of the IGF signal transduction pathway are not associated with intrauterine growth retardation and Silver-Russell syndrome. (11359473)	Eggermann T.... Wollmann H.	2001	IRS1
22	No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients. (11754049)	Kobayashi S.... Ishino F.	2001	MEST
23	Silver-Russell syndrome: a dissection of the genetic aetiology and candidate chromosomal regions. (11748303)	Hitchins M.P.... Moore G.E.	2001	CSH1
24	Maternal repression of the human GRB10 gene in the developing central nervous system; evaluation of the role for GRB10 in Silver-Russell syndrome. (11313740)	Hitchins M.P.... Moore G.E.	2001	GRB10
25	Evidence against GRB10 as the gene responsible for Silver-Russell syndrome. (11527390)	McCann J.A.... Polychronakos C.	2001	GRB10
26	Biallelic expression of IGFBP1 and IGFBP3, two candidate genes for the Silver-Russell syndrome. (10691413)	Wakeling E.L.... Preece M.A.	2000	IGFBP1
27	Duplication of 7p11.2-p13, including GRB10, in Silver-Russell syndrome. (10631135)	Monk D.... Moore G.E.	2000	GRB10
28	Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression. (10955473)	Russo S.... Larizza L.	2000	MEST
29	Identification of two new polymorphisms (c2447-125A>G; c2532G>A) in the gamma 2-COP (COPG2) gene by screening of Silver-Russell syndrome patients. (10874328)	Mergenthaler S.... Eggermann T.	2000	COPG2
30	Duplication of 7p12.1-p13, including GRB10 and IGFBP1, in a mother and daughter with features of Silver-Russell syndrome. (10987657)	Joyce C.A.... Temple I.K.	1999	GRB10, IGFBP1
31	Screening for mutations in the promoter and the coding region of the IGFBP1 and IGFBP3 genes in Silver-Russell syndrome patients. (10364674)	Eggermann K.... Eggermann T.	1999	IGFBP1
32	Paternally inherited deletion of CSH1 in a patient with Silver-Russell syndrome. (9733042)	Eggermann T.... Wollmann H.A.	1998	CSH1, RSS
33	Human EGFR, a candidate gene for the Silver-Russell syndrome, is biallelically expressed in a wide range of fetal tissues. (9781061)	Wakeling E.L.... Moore G.E.	1998	EGFR
34	Evidence against a major role of PEG1/MEST in Silver-Russell syndrome. (9781054)	Riesewijk A.M.... Kalscheuer V.M.	1998	MEST
35	Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome gene. (9448292)	Miyoshi N.... Ishino F.	1998	GRB10, SCYL1
36	Uniparental disomy 7 in Silver-Russell syndrome and primordial growth retardation. (7633407)	Kotzot D.... Hergersberg M.	1995	COL1A2
37	Low levels of somatomedin C and short stature in the Silver-Russell syndrome (8078790)	Di Pietro A.... Tammaro V.	1994	IGF1
38	Second observation of Silver-Russel syndrome in a carrier of a reciprocal translocation with one breakpoint at site 17q25. (8403458)	Midro A.T.... Rogowska M.	1993	GRB10, RSS
39	Severe Silver-Russell syndrome and translocation (17;20) (q25;q13) (1633648)	Ramirez-Duenas M.L.... Rivera H.	1992	GRB10, RSS

Genes related to silver-russell syndrome according to GeneCards:

(show all 41)

id	Symbol	Description	Score	GeneCards Section Context
1	CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	11.1	Summaries, Publications
2	IGF2	insulin-like growth factor 2 (somatomedin A)	11.1	Publications, Summaries
3	RSS	Russell Silver syndrome	11.0	Publications
4	MESTIT1	MEST intronic transcript 1, antisense RNA	11.0	Publications
5	MEST	mesoderm specific transcript homolog (mouse)	11.0	Functions, Publications
6	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0	Publications
7	FAM50B	family with sequence similarity 50, member B	11.0	Disorders
8	CPA1	carboxypeptidase A1 (pancreatic)	11.0	Publications
9	CPA5	carboxypeptidase A5	11.0	Publications
10	SCYL1	SCY1-like 1 (S. cerevisiae)	11.0	Publications
11	GRB7	growth factor receptor-bound protein 7	11.0	Publications
12	DNMT3L	DNA (cytosine-5-)-methyltransferase 3-like	11.0
13	CPA2	carboxypeptidase A2 (pancreatic)	11.0
14	CPA4	carboxypeptidase A4	11.0	Publications
15	ZNF597	zinc finger protein 597	11.0	Disorders
16	ZFP57	zinc finger protein 57 homolog (mouse)	11.0
17	SUDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	11.0
18	COPG2	coatomer protein complex, subunit gamma 2	11.0	Functions, Publications
19	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
20	GRB10	growth factor receptor-bound protein 10	11.0	Publications
21	PPP4R1	protein phosphatase 4, regulatory subunit 1	11.0
22	MBD3	methyl-CpG binding domain protein 3	11.0	Publications
23	COL1A2	collagen, type I, alpha 2	11.0	Publications
24	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications, Functions
25	SGCE	sarcoglycan, epsilon	11.0
26	TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	11.0
27	WDR20	WD repeat domain 20	11.0	Disorders
28	LEMD3	LEM domain containing 3	11.0	Disorders
29	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	11.0	Publications
30	GRAP2	GRB2-related adaptor protein 2	11.0
31	GRB14	growth factor receptor-bound protein 14	11.0	Disorders
32	COBL	cordon-bleu homolog (mouse)	11.0	Disorders
33	IRS1	insulin receptor substrate 1	11.0	Publications
34	GRB2	growth factor receptor-bound protein 2	11.0	Publications
35	CTCF	CCCTC-binding factor (zinc finger protein)	11.0
36	IGFBP3	insulin-like growth factor binding protein 3	11.0
37	TNS3	tensin 3	11.0
38	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
39	IGF1R	insulin-like growth factor 1 receptor	11.0
40	C7orf10	chromosome 7 open reading frame 10	11.0
41	EGFR	epidermal growth factor receptor	11.0	Publications

Pathways related to silver-russell syndrome according to GeneDecks:

(show all 40)

id	Pathway	Score	Top Affiliating Genes
1	JNK Pathway36	10.0	GRB2, IRS1
2	Caspase Cascade36	9.8	GRB7, GRB2, GRB14, GRB10
3	Angiopoietin-TIE2 Signaling36	9.7	GRB14, GRB2, GRB7
4	Focal adhesion20	9.6	GRB2, COL1A2, EGFR
5	Development_EGFR signaling via PIP341	9.5	EGFR, GRB2, IRS1
6	Development EGFR signaling via PIP310	9.5	EGFR, GRB2, IRS1
7	Growth Hormone Signaling36	9.3	IRS1, IGF1R, IGF2, IGF1
8	Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis41	9.3	IGF1, IGF2, IGF1R, IRS1
9	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis10	9.2	IGF1, IGF2, IGF1R, IRS1
10	Apoptosis and survival_Caspase cascade41	9.0	IGF1, IGF1R, IRS1
11	Apoptosis and survival BAD phosphorylation10	8.9	IRS1, GRB2, IGF1R, EGFR
12	IGF1R Signaling36	8.9	IGF1, IGF2, IGF1R, GRB2, IRS1
13	Apoptosis and survival_BAD phosphorylation41	8.9	EGFR, IGF1R, GRB2, IRS1
14	Cell adhesion_ECM remodeling41	8.9	EGFR, COL1A2, IGF1, IGF2, IGF1R
15	Cell adhesion ECM remodeling10	8.9	EGFR, COL1A2, IGF1, IGF2, IGF1R
16	Apoptosis and survival Caspase cascade10	8.9	IGF1, IGF1R, IRS1
17	Tyrosine Kinases / Adaptors3	8.9	EGFR, IGF1R, GRB2, GRB10, IRS1
18	Glioma20	8.8	EGFR, IGF1, IGF1R, GRB2
19	Transcription_Androgen Receptor nuclear signaling41	8.8	EGFR, IGF1, IGF1R, GRB2
20	Transcription Androgen Receptor nuclear signaling10	8.8	GRB2, IGF1R, IGF1, EGFR
21	Glioblastoma Multiforme36	8.8	GRB2, IGF1R, IGF2, IGF1, EGFR
22	Prostate cancer20	8.7	GRB2, IGF1R, IGF1, EGFR
23	Transcription_Receptor-mediated HIF regulation41	8.7	IGF1, IGFBP3, IGF1R, GRB2, IRS1
24	Transcription Receptor-mediated HIF regulation10	8.7	IGF1, IGFBP3, IGF1R, GRB2, IRS1
25	Signal transduction_PTEN pathway41	8.6	GRB2, IGF1R, IGF1, EGFR, IRS1
26	Signal transduction PTEN pathway10	8.6	EGFR, IGF1, IGF1R, GRB2, IRS1
27	Development Ligand-independent activation of ESR1 and ESR210	8.6	EGFR, IGF1, IGF1R, GRB2, IRS1
28	Development_Ligand-independent activation of ESR1 and ESR241	8.5	EGFR, IGF1, IGF1R, GRB2, IRS1
29	BAD Phosphorylation36	8.5	EGFR, IGF1, IGF1R, GRB2, IRS1
30	PPAR Pathway36	8.5	EGFR, IGF1, IGF2, IGF1R, GRB2
31	eIF2 Pathway36	8.5	EGFR, IGF1, IGF2, IGF1R, GRB2
32	PTEN Pathway36	8.5	EGFR, COL1A2, IGF1, IGF2, IGF1R, GRB2
33	Rap1 Pathway36	8.5	EGFR, IGF1, IGF2, IGF1R, GRB2, GRAP2
34	Nanog in Mammalian ESC Pluripotency36	8.4	EGFR, IGF1, IGF2, IGF1R, GRB2
35	p70S6K Signaling36	8.4	EGFR, IGF1, IGF2, IGF1R, GRB2, IRS1
36	Development IGF-RI signaling10	8.4	IRS1, IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
37	Development_IGF-1 receptor signaling41	8.4	IGF1, IGFBP3, IGF2, IGF1R, IGFBP1, GRB2
38	Phospholipase-C Pathway36	8.3	EGFR, COL1A2, IGF1, IGF2, IGF1R, GRB2
39	Breast Cancer Regulation by Stathmin136	8.2	EGFR, IGF1, IGF2, IGF1R, GRB7, GRB2
40	Signaling Involved in Cardiac Hypertrophy36	7.8	EGFR, IGF1, IGF1R, GRB2, IRS1

Compounds related to silver-russell syndrome according to GeneDecks:

(show top 50)    (show all 63)

id	Compound	Score	Top Affiliating Genes
1	rsai32	10.3	H19, COL1A2, IGF2, IGFBP1
2	ethylenediaminetetraacetate32	10.2	IGF2, IGFBP3
3	2,4-dinitrophenol32	9.8	IRS1, IGF2, IGF1
4	exemestane32 34 9 9	12.8	IGF2, IGFBP3, EGFR
5	iplex32	9.8	IGFBP3, IGF1
6	megestrol acetate32	9.8	IGF2, IGFBP3, IGF1
7	disuccinimidyl suberate32	9.7	IGFBP3, IGF2, IGF1R
8	pegvisomant32 9 9	11.7	IGF1, IGFBP3, IGF2, IGFBP1
9	anastrozole32 42 9 9	12.7	EGFR, IGFBP3, IGF2, IGFBP1
10	pyridostigmine32 9 9	11.7	IGFBP3, IGF1, IGFBP1
11	cetrorelix32 9 9	11.7	EGFR, IGF2, IGF1
12	lanreotide32	9.6	IGFBP1, IGFBP3, IGF1
13	buserelin32 9 9	11.6	IGFBP1, IGFBP3, IGF1
14	dehydroepiandrosterone sulfate32	9.6	IGF1, IGFBP3, IGF2, IGFBP1
15	5-aza-2deoxycytidine32	9.5	H19, CTCF, IGFBP3, IGF2, CDKN1C
16	levonorgestrel32 9 9	11.5	IGFBP3, IGF2, IGFBP1
17	dhea32	9.5	IGF1, IGFBP3, IGF2, IGFBP1
18	triiodothyronine32	9.4	IGF1, IGFBP3, IGF2, IGFBP1
19	acth32	9.4	H19, IGF1, IGFBP3, IGF2, IGFBP1, CDKN1C
20	mecasermin32 9 9	11.3	IGF1R, IGFBP3, IGF1
21	estrone32 9 18 9	12.3	IGF1, IGFBP3, IGF2, IGFBP1, IRS1
22	phosphatidylinositol32	9.3	EGFR, COL1A2, IGF2, IGFBP1, GRB7, IRS1
23	androstenedione32 18	10.2	IGF1, IGFBP3, IGF2, IGFBP1
24	eb 108932	9.2	IGF1R, IGF2, IGFBP3, IGF1
25	metformin32 34 9 9	12.2	EGFR, IGF1, IGFBP1, IRS1
26	clomiphene citrate32	9.1	IGFBP1, IGF1R, IGFBP3, IGF1
27	2-deoxyglucose32	9.1	IGF1, IGF2, IGF1R, IGFBP1, IRS1
28	letrozole32 42 9 9	12.1	EGFR, IGF1, IGFBP3, GRB2
29	octreotide32 42 9 9	12.0	IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
30	dihydrotestosterone32 9 18 9	11.9	IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
31	4-hydroxytamoxifen32	8.9	IGF1R, IGF2, IGF1, EGFR
32	ag 102432	8.8	IRS1, IGF1R, IGF2, IGF1, EGFR
33	agar32	8.8	H19, EGFR, IGF2, IGF1R, GRB2, IRS1
34	lycopene32 18	9.8	IGF1R, IGFBP3, IGF1
35	calcitriol32 42 9 18 9	12.8	TGM1, IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
36	c-peptide32	8.8	IGF1, IGFBP3, IGF2, IGF1R, IGFBP1, IRS1
37	ribonucleic acid32	8.7	H19, COL1A2, IGF1, IGFBP3, IGF2, IGF1R
38	vitamin d32	8.6	TGM1, COL1A2, IGF1, IGFBP3, IGF2, IGF1R
39	progestin32	8.5	EGFR, IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
40	ag 147832	8.5	IRS1, GRB2, IGF1R, IGF1, EGFR
41	phosphotyrosine32	8.3	EGFR, IGF2, IGF1R, GRB7, GRB2, GRB14
42	rapamycin32 42	9.3	EGFR, IGF1, IGF2, IGF1R, IGFBP1, IRS1
43	steroid32	8.1	H19, TGM1, CTCF, IGF1, IGFBP3, IGF2
44	cycloheximide32	8.0	EGFR, IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
45	thymidine32 18	8.9	H19, TGM1, COL1A2, IGF1, IGFBP3, IGF2
46	ly29400232	7.9	EGFR, COL1A2, IGF1, IGFBP3, IGF2, IGF1R
47	tamoxifen32 34 9 9	10.9	EGFR, IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
48	retinoic acid32 42 18	9.4	H19, TGM1, EGFR, IGF1, IGFBP3, IGF2
49	estrogen32	7.2	COL1A2, IGF1, IGFBP3, IGF2, IGF1R, IGFBP1
50	tyrosine32	6.8	IGF2BP3, IGF1, COL1A2, EGFR, CPA1, H19

Cellular components related to silver-russell syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor binding protein complex	GO:016942	9.5	IGFBP3, IGF1

Biological processes related to silver-russell syndrome according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of gene expression by genetic imprinting	GO:006349	9.9	DNMT3L, CTCF, IGF2, ZFP57
2	negative regulation of insulin receptor signaling pathway	GO:046627	9.8	GRB14, GRB10, IRS1
3	positive regulation of glycogen biosynthetic process	GO:045725	9.7	IRS1, IGF2, IGF1
4	leukocyte migration	GO:050900	9.5	GRB14, GRB2, GRB7, COL1A2
5	positive regulation of phosphorylation	GO:042327	9.5	IRS1, GRB10, EGFR
6	insulin-like growth factor receptor signaling pathway	GO:048009	9.0	IGF1, IGF1R, GRB10, IRS1
7	positive regulation of cell migration	GO:030335	8.8	EGFR, IGF1R, GRB7, IRS1
8	insulin receptor signaling pathway	GO:008286	8.7	IRS1, GRB10, GRB14, GRB2, IGFBP1, IGF1R
9	positive regulation of DNA replication	GO:045740	8.5	IGF1R, IGF1, EGFR
10	positive regulation of cell proliferation	GO:008284	7.9	EGFR, TNS3, IGF1, IGF2, IGF1R, IRS1

Molecular functions related to silver-russell syndrome according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	metallocarboxypeptidase activity	GO:004181	10.0	CPA5, CPA4, CPA2, CPA1
2	insulin-like growth factor receptor binding	GO:005159	9.5	IRS1, IGF2, IGF1
3	insulin-like growth factor-activated receptor activity	GO:005010	9.5	IRS1, IGF1R
4	SH3/SH2 adaptor activity	GO:005070	9.4	GRB7, GRB2, GRB14, GRB10, GRAP2
5	insulin-like growth factor binding	GO:005520	8.9	IGFBP1, IGF1R, IGFBP3
6	insulin receptor binding	GO:005158	8.9	IRS1, GRB10, IGF1R, IGF2, IGF1
7	protein binding	GO:005515	4.4	IGF1, TNS3, SUDS3, CTCF, PPP4R1, COL1A2