Silver Spastic Paraplegia Syndrome malady

MalaCards: Silver Spastic Paraplegia Syndrome, also known as spastic paraplegia 17, is related to spastic paraplegia and paraplegia. An important gene associated with Silver Spastic Paraplegia Syndrome is BSCL2 (Berardinelli-Seip congenital lipodystrophy 2 (seipin)).

OMIM: 270685

silver spastic paraplegia syndrome 7 33 spastic paraplegia 17 43

Diseases related to silver spastic paraplegia syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 110)

id	Related Disease	Score	Top Affiliating Genes
1	spastic paraplegia	13.6
2	paraplegia	13.6
3	spasticity	13.6
4	hereditary spastic paraplegia	13.3
5	spastic paraplegia type 11	10.8
6	spastic paraplegia type 4	10.6
7	spastic paraplegia 3a	10.3
8	spastic paraplegia 8	10.2
9	pelizaeus-merzbacher disease	10.0
10	corpus callosum	9.8
11	troyer syndrome	9.8
12	neuropathy	9.3
13	spastic paraplegia 15	9.3
14	spg11-related hereditary spastic paraplegia with thin corpus callosum	9.2
15	spastic paraplegia 20	9.0
16	spastic paraplegia 5a	9.0
17	spastic paraplegia 6	9.0
18	spastic paraplegia 10	8.8
19	spastic paraplegia 31	8.8
20	spastic paraplegia 3	8.6
21	spastic paraplegia 39	8.6
22	spastic paraplegia 44	8.6
23	axonal neuropathy	8.6
24	spastic paraplegia 1	8.6
25	spastic paraplegia 13	8.6
26	spastic paraplegia 23	8.6
27	masa syndrome	8.4
28	spastic paraplegia 25	8.4
29	spastic paraplegia with precocious puberty	8.4
30	spastic paraplegia 33	8.4
31	spastic paraplegia 42	8.4
32	spastic paraplegia 9	8.1
33	spastic paraplegia neuropathy poikiloderma	8.1
34	spastic paraplegia 30	8.1
35	spastic paraplegia, optic atrophy, and neuropathy	8.1
36	hydrocephalus	8.1
37	neuronitis	8.1
38	spastic paraplegia 12	8.1
39	spastic paraplegia 18	8.1
40	spastic paraplegia 19	8.1
41	spastic paraplegia 24	8.1
42	spastic paraplegia 26	8.1
43	spastic paraplegia 29	8.1
44	spastic paraplegia 17	7.8
45	spastic paraplegia 34, x-linked	7.7
46	spastic paraplegia-38	7.7
47	spastic paraplegia 45	7.7
48	spastic paraplegia-37	7.7
49	ataxia	7.7
50	spastic paraplegia-32	7.7

Clinical features from OMIM: 270685

Approved drugs:

Drug clinical trials:

Genes related to silver spastic paraplegia syndrome according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	11.0	Disorders