SNUC
MCID: SNN002
MIFTS: 27

Sinonasal Undifferentiated Carcinoma (SNUC) malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

Aliases & Descriptions for Sinonasal Undifferentiated Carcinoma:

Name: Sinonasal Undifferentiated Carcinoma 50 69
Highly Aggressive Undifferentiated Carcinoma of the Nasal Cavity and Paranasal Sinuses 50
Snuc 50

Classifications:



Summaries for Sinonasal Undifferentiated Carcinoma

NIH Rare Diseases : 50 sinonasal undifferentiated carcinoma (snuc) is a type of cancer that develops in the sinuses of the head. snuc occurs when cells from the layer of tissue that lines the sinuses (called the epithelium) rapidly increase in number, forming a mass. the first symptoms of snuc may include difficulty breathing though the nose or mild facial pain. as snuc progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face. snuc is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body (metastasis). the cause of snuc is still unknown. when possible, the treatment is the complete removal of the tumor, combined with radiation therapy and chemotherapy. in cases where the tumor can't be removed completely, the treatment is with radiation and chemotherapy. the risk of the tumor coming back (relapse) is high and the probability of cure is modest. last updated: 11/10/2016

MalaCards based summary : Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to infiltrating renal pelvis transitional cell carcinoma and thymus small cell carcinoma. An important gene associated with Sinonasal Undifferentiated Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways is Neuroscience. The drugs Doxorubicin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include skin and liver.

Wikipedia : 71 Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare aggressive type of cancer that arises... more...

Related Diseases for Sinonasal Undifferentiated Carcinoma

Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 infiltrating renal pelvis transitional cell carcinoma 10.2 ENO2 SYP
2 thymus small cell carcinoma 10.2 ENO2 SYP
3 glomus tumor 10.2 ENO2 SYP
4 pemphigus foliaceus 10.2 ENO2 SYP
5 spasmodic dysphonia 10.2 ENO2 SYP
6 ampullary signet ring cell adenocarcinoma 10.2 ENO2 SYP
7 nephrogenic adenoma of urinary bladder 10.2 ENO2 SYP
8 perineural angioma 10.2 ENO2 SYP
9 blood group incompatibility 10.2 ENO2 SYP
10 gliofibroma 10.2 ENO2 SYP
11 rectum leiomyoma 10.2 ENO2 SYP
12 superior vena cava syndrome 10.2 ENO2 SYP
13 fragile x-associated tremor/ataxia syndrome 10.2 ENO2 SYP
14 gallbladder pleomorphic giant cell adenocarcinoma 10.2 ENO2 SYP
15 adult epithelioid sarcoma 10.2 ENO2 SYP
16 piussan lenaerts mathieu syndrome 10.2 ENO2 SYP
17 anal squamous cell carcinoma 10.2 ENO2 SYP
18 uterine corpus myxoid leiomyosarcoma 10.2 ENO2 SYP
19 thoracic benign neoplasm 10.2 ENO2 SYP
20 microsporidiosis 10.2 ENO2 SYP
21 gamma heavy chain disease 10.2 ENO2 SYP
22 pediculus humanus corporis infestation 10.2 ENO2 SYP
23 hunter macpherson syndrome 10.2 ENO2 SYP
24 rh isoimmunization 10.2 ENO2 SYP
25 vulvar alveolar soft part sarcoma 10.2 ENO2 SYP
26 ampulla of vater mucinous adenocarcinoma 10.2 ENO2 SYP
27 vulvar granular cell tumor 10.1 ENO2 SYP
28 childhood central nervous system primitive neuroectodermal neoplasm 10.1 ENO2 SYP
29 cardioauditory syndrome of sanchez cascos 10.1 ENO2 SYP
30 multiple chemical sensitivity 10.1 ENO2 SYP
31 clear cell variant infiltrating bladder urothelial carcinoma 10.1 ENO2 SYP
32 brucella canis brucellosis 10.1 ENO2 SYP
33 myoepithelial carcinoma 10.1 ENO2 SYP
34 acute stress disorder 10.1 ENO2 SYP
35 pharynx cancer 10.1 ENO2 SYP
36 granulomatous myositis 10.1 ENO2 SYP
37 childhood medulloblastoma 10.1 ENO2 SYP
38 sternum lymphoma 10.1 ENO2 SYP
39 spindle cell rhabdomyosarcoma 10.1 ENO2 SYP
40 brachial plexus neuropathy 10.1 ENO2 SYP
41 colorectal cancer 1 10.1 ENO2 SYP
42 extrahepatic biliary papillomatosis 10.1 MKI67 SYP
43 zollinger-ellison syndrome 10.1 ENO2 SYP
44 oral leukoedema 10.1 ENO2 SYP
45 endocrine organ benign neoplasm 10.1 ENO2 SYP
46 atopic dermatitis 10.1 ENO2 SYP
47 postmenopausal atrophic vaginitis 10.1 ENO2 SYP
48 cystadenoma 10.1 ENO2 SYP
49 testicular trophoblastic tumor 10.1 MKI67 SYP
50 myelinoclastic diffuse sclerosis 10.1 ENO2 MUC1

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to Sinonasal Undifferentiated Carcinoma

Symptoms & Phenotypes for Sinonasal Undifferentiated Carcinoma

Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

Drugs for Sinonasal Undifferentiated Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
4
Ifosfamide Approved Phase 2 3778-73-2 3690
5
Mechlorethamine Approved Phase 2 51-75-2 4033
6
Fluorouracil Approved Phase 2 51-21-8 3385
7
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
8
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
9
Doxil Approved June 1999 Phase 2 31703
10 Alkylating Agents Phase 2
11 Topoisomerase Inhibitors Phase 2
12 Pharmaceutical Solutions Phase 2
13 Anti-Bacterial Agents Phase 2
14 Etoposide phosphate Phase 2
15 Immunosuppressive Agents Phase 2
16 Isophosphamide mustard Phase 2
17 Antimetabolites Phase 2
18 Antibiotics, Antitubercular Phase 2
19 Antimetabolites, Antineoplastic Phase 2
20 Antimitotic Agents Phase 2
21 Antineoplastic Agents, Alkylating Phase 2
22 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Inoperable Patients Recruiting NCT02099188 Phase 2
2 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Operable Patients Recruiting NCT02099175 Phase 2
3 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Recruiting NCT01586767 Phase 2

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

Anatomical Context for Sinonasal Undifferentiated Carcinoma

MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

39
Skin, Liver

Publications for Sinonasal Undifferentiated Carcinoma

Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50) (show all 86)
id Title Authors Year
1
Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma. ( 28084339 )
2017
2
Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma. ( 27703092 )
2017
3
A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience. ( 27938440 )
2017
4
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma. ( 26752332 )
2016
5
Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database. ( 27717204 )
2016
6
Significance of Tumor Stage in Sinonasal Undifferentiated Carcinoma Survival: A Population-Based Analysis. ( 26908559 )
2016
7
Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature. ( 26829682 )
2016
8
Pre-operative chemoradiation for sinonasal undifferentiated carcinoma of the anterior nasal cavity resected through a lateral nasal flap approach. ( 26954865 )
2016
9
Sinonasal Undifferentiated Carcinoma Presenting With Bilateral Compressive Optic Neuropathy. ( 27281738 )
2016
10
Role of (18) F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma. ( 27481043 )
2016
11
Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation. ( 25685767 )
2015
12
Sinonasal undifferentiated carcinoma as a third primary neoplasm: A case report and review of the literature. ( 25923276 )
2015
13
Current management of sinonasal undifferentiated carcinoma. ( 26363162 )
2015
14
Nodal Metastasis and Elective Nodal Level Treatment in Sinonasal Small Cell and Sinonasal Undifferentiated Carcinoma: A Surveillance, Epidemiology and End Results Analysis. ( 26559439 )
2015
15
Reappraisal of sinonasal undifferentiated carcinoma: SMARCB1 (INI1)-deficient sinonasal carcinoma: a single-institution experience. ( 26407663 )
2015
16
Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. ( 25844294 )
2015
17
Esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma: differentiation in diagnosis and treatment. ( 25992139 )
2014
18
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma. ( 25017972 )
2014
19
Treatment outcomes and prognostic factors including human papillomavirus (HPV) for sinonasal undifferentiated carcinoma: A retrospective review. ( 24421248 )
2014
20
Molecular profiling of sinonasal undifferentiated carcinoma. ( 23633104 )
2014
21
Sinonasal undifferentiated carcinoma and esthesioneuroblastoma recurring as nonintestinal adenocarcinoma. ( 23553283 )
2013
22
Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. ( 23993024 )
2013
23
Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers. ( 23477516 )
2013
24
Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. ( 23663264 )
2013
25
Radiotherapy for sinonasal undifferentiated carcinoma. ( 24268566 )
2013
26
Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma. ( 23471826 )
2013
27
Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. ( 22476411 )
2013
28
Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy. ( 23462605 )
2013
29
Trimodality management of sinonasal undifferentiated carcinoma and review of the literature. ( 22992621 )
2013
30
Sinonasal undifferentiated carcinoma presenting as recurrent fronto-ethmoidal pyomucocele. ( 23251060 )
2012
31
Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. ( 22460731 )
2012
32
Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. ( 23032744 )
2012
33
Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. ( 21041001 )
2011
34
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). ( 21805120 )
2011
35
Prognostic factors for patients with sinonasal undifferentiated carcinoma. ( 21225771 )
2010
36
Sinonasal undifferentiated carcinoma metastatic to the skin. ( 19682175 )
2010
37
Sinonasal undifferentiated carcinoma: a 13-year experience at a single institution. ( 20808529 )
2010
38
Primary ocular presentation of sinonasal undifferentiated carcinoma. ( 20090496 )
2010
39
Pediatric sinonasal undifferentiated carcinoma: case report and literature review. ( 21059557 )
2010
40
Clinical manifestations of sinonasal undifferentiated carcinoma. ( 20013673 )
2009
41
Sinonasal undifferentiated carcinoma, or schneiderian carcinoma arising from an aspergillosis: a case history. ( 19211176 )
2009
42
Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression. ( 19283847 )
2009
43
Management of sinonasal undifferentiated carcinoma. ( 18383526 )
2008
44
The cytologic features of sinonasal undifferentiated carcinoma and olfactory neuroblastoma. ( 18285258 )
2008
45
Patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. ( 18207030 )
2008
46
Report of a case of sinonasal undifferentiated carcinoma arising in a background of extensive nasal gliomatosis. ( 17972313 )
2008
47
Sinonasal undifferentiated carcinoma with a frozen globe. ( 18520842 )
2008
48
Diagnosis and treatment of sinonasal undifferentiated carcinoma: report of a case and review of the literature. ( 18571040 )
2008
49
Liver transplantation for metastatic sinonasal undifferentiated carcinoma: a case report. ( 19100503 )
2008
50
Primary sinonasal undifferentiated carcinoma presenting with bilateral retrobulbar optic neuropathy. ( 17895819 )
2007

Variations for Sinonasal Undifferentiated Carcinoma

Expression for Sinonasal Undifferentiated Carcinoma

Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for Sinonasal Undifferentiated Carcinoma

Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.31 ENO2 MKI67 SYP

GO Terms for Sinonasal Undifferentiated Carcinoma

Sources for Sinonasal Undifferentiated Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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