SNUC
MCID: SNN002
MIFTS: 44

Sinonasal Undifferentiated Carcinoma (SNUC) malady

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Summaries for Sinonasal Undifferentiated Carcinoma

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NIH Rare Diseases:42 Sinonasal undifferentiated carcinoma (snuc) is a type of cancer that develops in the sinuses of the head.  snuc occurs when cells from the layer of tissue that lines the sinuses (called the epithelium) rapidly increase in number, forming a mass.  the first symptoms of snuc may include difficulty breathing though the nose or mild facial pain.  as snuc progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face.  snuc is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body (metastasis).  treatment may include surgery, chemotherapy, and radiation therapy. last updated: 1/22/2013

MalaCards based summary: Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to neuroendocrine carcinoma and adenocarcinoma. An important gene associated with Sinonasal Undifferentiated Carcinoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Endocytosis. The compounds ptk787 and zd6474 have been mentioned in the context of this disorder. Affiliated tissues include liver and skin, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Wikipedia:65 Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare aggressive type of cancer that arises... more...

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

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Sinonasal Undifferentiated Carcinoma, Aliases & Descriptions:

Name: Sinonasal Undifferentiated Carcinoma 42 62
Highly Aggressive Undifferentiated Carcinoma of the Nasal Cavity and Paranasal Sinuses 42
 
Snuc 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Sinonasal Undifferentiated Carcinoma

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Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma30.6KIT, KRT7
2adenocarcinoma30.0ERBB2, KRT7, EGFR
3olfactory neuroblastoma10.4
4nasopharyngitis10.4
5neuroblastoma10.4
6sinusitis10.3
7schneiderian carcinoma10.3
8aspergillosis10.3
9neuropathy10.3
10bronchiolo-alveolar adenocarcinoma10.2EGFR, KRT7
11adenosquamous carcinoma10.2EGFR, KRT7
12mucoepidermoid carcinoma10.2EGFR, KRT7
13thymus cancer10.2KRT7, KIT
14dysgerminoma10.2KIT, KRT7
15malignant peripheral nerve sheath tumor10.1EGFR, KIT
16oxyphilic adenoma10.1KIT, KRT7
17synovial sarcoma10.1KRT7, KIT
18teratoma10.1KIT, KRT7
19mammary paget's disease10.1KRT7, ERBB2
20cutaneous paget's disease10.1KRT7, ERBB2
21biliary tract neoplasm10.1ERBB2, EGFR
22inflammatory breast carcinoma10.1ERBB2, EGFR
23lung benign neoplasm10.1KRT7, EGFR
24ductal carcinoma in situ10.1EGFR, ERBB2
25tubular adenocarcinoma10.1KRT7, ERBB2
26breast ductal carcinoma10.1EGFR, ERBB2
27uterine carcinosarcoma10.0ERBB2, KIT
28bladder carcinoma in situ10.0EGFR, ERBB2
29pancreatic cancer10.0EGFR, KRT7
30diarrhea10.0EGFR, ERBB2
31papillary carcinoma10.0KRT7, ERBB2
32cholangiocarcinoma10.0ERBB2, KRT7
33neutropenia10.0EGFR, ERBB2
34gastric adenocarcinoma10.0KRT7, ERBB2
35non-small cell lung carcinoma9.9EGFR, ERBB2
36lung small cell carcinoma9.9EGFR, KRT7, KIT
37breast cancer9.9EGFR, ERBB2
38kidney cancer9.9KIT, KRT7, EGFR
39squamous cell carcinoma of the head and neck9.9EGFR, ERBB2
40large cell carcinoma9.9EGFR, KRT7, ERBB2
41transitional cell carcinoma9.9ERBB2, KRT7, EGFR
42lung adenocarcinoma9.8EGFR, KRT7, ERBB2
43stomach cancer9.8ERBB2, KRT7, EGFR
44cervical cancer9.8EGFR, ERBB2
45lung cancer9.8ERBB2, KRT7, EGFR
46prostate cancer9.8EGFR, KRT7, ERBB2
47malignant mixed mullerian tumor9.8KIT, ERBB2, KRT7
48salivary gland adenoid cystic carcinoma9.8KIT, ERBB2, KRT7
49factor vii deficiency9.8EGFR, ERBB2, KIT
50ovarian cancer9.8ERBB2, KRT7, EGFR

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to sinonasal undifferentiated carcinoma

Symptoms for Sinonasal Undifferentiated Carcinoma

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Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Sinonasal Undifferentiated Carcinoma

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

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Anatomical Context for Sinonasal Undifferentiated Carcinoma

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MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

32
Liver, Skin

Animal Models for Sinonasal Undifferentiated Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Sinonasal Undifferentiated Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7KIT, ERBB2, EGFR
2MP:00020068.6EGFR, ERBB2, KIT
3MP:00053678.6EGFR, KRT7, KIT
4MP:00053828.6KIT, ERBB2, EGFR
5MP:00053698.5EGFR, ERBB2, KIT
6MP:00053888.4KIT, ERBB2, EGFR
7MP:00053818.2EGFR, ERBB2, KIT
8MP:00053848.2EGFR, KRT7, ERBB2, KIT

Publications for Sinonasal Undifferentiated Carcinoma

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Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Treatment outcomes and prognostic factors including human papillomavirus (HPV) for sinonasal undifferentiated carcinoma: A retrospective review. (24421248)
2014
2
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma. (25017972)
2014
3
Trimodality management of sinonasal undifferentiated carcinoma and review of the literature. (22992621)
2013
4
Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy. (23462605)
2013
5
Radiotherapy for sinonasal undifferentiated carcinoma. (24268566)
2013
6
Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. (23663264)
2013
7
Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers. (23477516)
2013
8
Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma. (23471826)
2013
9
Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. (22476411)
2013
10
Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. (23993024)
2013
11
Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. (22460731)
2012
12
Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. (23032744)
2012
13
Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. (21041001)
2011
14
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). (21805120)
2011
15
Pediatric sinonasal undifferentiated carcinoma: case report and literature review. (21059557)
2010
16
Sinonasal undifferentiated carcinoma: a 13-year experience at a single institution. (20808529)
2010
17
Primary ocular presentation of sinonasal undifferentiated carcinoma. (20090496)
2010
18
Prognostic factors for patients with sinonasal undifferentiated carcinoma. (21225771)
2010
19
Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression. (19283847)
2009
20
Clinical manifestations of sinonasal undifferentiated carcinoma. (20013673)
2009
21
The cytologic features of sinonasal undifferentiated carcinoma and olfactory neuroblastoma. (18285258)
2008
22
Management of sinonasal undifferentiated carcinoma. (18383526)
2008
23
Patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. (18207030)
2008
24
Sinonasal undifferentiated carcinoma with a frozen globe. (18520842)
2008
25
Diagnosis and treatment of sinonasal undifferentiated carcinoma: report of a case and review of the literature. (18571040)
2008
26
Report of a case of sinonasal undifferentiated carcinoma arising in a background of extensive nasal gliomatosis. (17972313)
2008
27
Intracranial sinonasal undifferentiated carcinoma (SNUC) in a child. (16555080)
2006
28
Sinonasal undifferentiated carcinoma of the maxillary sinus. (16545179)
2006
29
Sinonasal undifferentiated carcinoma. (16462499)
2006
30
Sinonasal undifferentiated carcinoma with intracranial extension. (22496625)
2006
31
Sinonasal undifferentiated carcinoma: an update. (16012246)
2005
32
Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. (15900114)
2005
33
Sinonasal undifferentiated carcinoma: case series and literature review. (15124164)
2004
34
Unusual cases involving the CNS and nasal sinuses: Case 2. Sinonasal undifferentiated carcinoma. (14551308)
2003
35
Sinonasal undifferentiated carcinoma: the search for a better outcome. (12172261)
2002
36
Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities. (11859210)
2002
37
Drop metastasis from sinonasal undifferentiated carcinoma: clinical implications. (11458156)
2001
38
Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association. (11176064)
2001
39
Sinonasal undifferentiated carcinoma with orbital invasion: report of three cases. (11476180)
2001
40
Esthesioneuroblastoma and sinonasal undifferentiated carcinoma: impact of histological grading and clinical staging on survival and prognosis. (10942123)
2000
41
Sinonasal undifferentiated carcinoma: a distinctive clinicopathologic entity. (10562893)
1999
42
Sinonasal undifferentiated carcinoma. (9511119)
1998
43
Sinonasal undifferentiated carcinoma: report of two cases and review of the literature. (9503454)
1998
44
Sinonasal undifferentiated carcinoma: a 10-year experience. (8827275)
1996
45
Pathologic quiz case 2. Sinonasal undifferentiated carcinoma (SNUC). (7546592)
1995
46
Sinonasal undifferentiated carcinoma invading the orbit. (7711477)
1994
47
Sinonasal undifferentiated carcinoma: a ray of hope. (8516007)
1993
48
High-dose chemotherapy and autologous marrow transplantation for esthesioneuroblastoma and sinonasal undifferentiated carcinoma. (2658537)
1989
49
Sinonasal undifferentiated carcinoma: a distinctive and highly aggressive neoplasm. (3613787)
1987
50
Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. (2430477)
1986

Variations for Sinonasal Undifferentiated Carcinoma

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Expression for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Expression patterns in normal tissues for genes affiliated with Sinonasal Undifferentiated Carcinoma

Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1KIT, EGFR
29.1EGFR, KIT
3
Show member pathways
9.1EGFR, KIT
49.1EGFR, KRT7
5
Show member pathways
9.0ERBB2, EGFR
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.0EGFR, ERBB2
79.0EGFR, ERBB2
8
Show member pathways
9.0EGFR, ERBB2
99.0ERBB2, EGFR
109.0EGFR, ERBB2
11
Show member pathways
9.0EGFR, ERBB2
12
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.0EGFR, ERBB2
139.0EGFR, ERBB2
14
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0EGFR, ERBB2
15
Show member pathways
Signaling Pathways in Glioblastoma37
9.0ERBB2, EGFR
169.0EGFR, ERBB2
17
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.0EGFR, ERBB2
18
Show member pathways
9.0ERBB2, EGFR
19
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0ERBB2, EGFR
209.0EGFR, ERBB2
219.0EGFR, ERBB2
229.0EGFR, ERBB2
239.0EGFR, ERBB2
24
Show member pathways
9.0ERBB2, EGFR
258.5KIT, ERBB2, EGFR
26
Show member pathways
8.5EGFR, ERBB2, KIT
278.5KIT, ERBB2, EGFR
288.5EGFR, ERBB2, KIT
29
Show member pathways
8.5KIT, ERBB2, EGFR
30
Show member pathways
8.5EGFR, ERBB2, KIT
31
Show member pathways
8.5EGFR, ERBB2, KIT
32
Show member pathways
8.5EGFR, ERBB2, KIT
33
Show member pathways
8.5KIT, ERBB2, EGFR
34
Show member pathways
8.5EGFR, ERBB2, KIT
35
Show member pathways
8.5KIT, ERBB2, EGFR
36
Show member pathways
8.5EGFR, ERBB2, KIT
37
Show member pathways
Signal transduction PTEN pathway60
8.5EGFR, ERBB2, KIT
38
Show member pathways
8.5KIT, ERBB2, EGFR
39
Show member pathways
8.5KIT, ERBB2, EGFR
40
Show member pathways
8.5KIT, ERBB2, EGFR
41
Show member pathways
8.5KIT, ERBB2, EGFR
42
Show member pathways
8.5EGFR, ERBB2, KIT
43
Show member pathways
8.5KIT, ERBB2, EGFR

Compounds for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Compounds related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1ptk787449.5KIT, EGFR
2zd6474449.5EGFR, KIT
3ag-1296449.5KIT, EGFR
4ag 1478 hydrochloride619.5ERBB2, EGFR
5pd158780449.4EGFR, ERBB2
6ag 490619.4EGFR, ERBB2
7iressa619.4ERBB2, EGFR
8afatinib50 1110.4EGFR, ERBB2
9su5416449.4KIT, EGFR
10jnj 28871063 hydrochloride619.4ERBB2, EGFR
11pertuzumab44 50 1111.4EGFR, ERBB2
12hrgbeta1449.4EGFR, ERBB2
13pki-166449.4EGFR, ERBB2
14quinazoline449.4ERBB2, EGFR
15erbstatin449.4EGFR, ERBB2
16exemestane44 50 61 1112.3EGFR, ERBB2
17anastrozole44 50 1111.3ERBB2, EGFR
18pd153035449.3ERBB2, EGFR
19lapatinib44 50 1111.3EGFR, ERBB2
20regorafenib50 1110.2KIT, EGFR
215-methylthioadenosine449.2ERBB2, EGFR
22formaldehyde44 2410.2KRT7, ERBB2, KIT
23fulvestrant44 50 28 1112.2ERBB2, EGFR
24methotrexate50 44 1111.2KIT, ERBB2, KRT7
25dasatinib44 50 1111.1EGFR, KIT
26taxane449.1EGFR, ERBB2
27vinorelbine44 50 1111.0ERBB2, EGFR
28capecitabine44 50 1111.0KIT, ERBB2, EGFR
29everolimus44 50 1111.0KIT, EGFR, ERBB2
30sunitinib44 50 1111.0EGFR, ERBB2, KIT
31erlotinib44 50 1111.0ERBB2, EGFR, KIT
32flavopiridol44 1110.0ERBB2, EGFR, KIT
33trastuzumab44 50 1110.9EGFR, KIT, ERBB2
34gefitinib44 50 1110.9ERBB2, KIT, EGFR
35irinotecan44 50 1110.9ERBB2, EGFR, KIT
36geldanamycin44 50 61 1111.9ERBB2, EGFR, KIT
37letrozole44 50 61 1111.9EGFR, ERBB2
38docetaxel44 50 61 1111.9KIT, ERBB2, EGFR
39imatinib44 50 1110.9EGFR, ERBB2, KIT
405fluorouracil448.8KIT, ERBB2, EGFR
41phosphotyrosine448.8KIT, EGFR, ERBB2
42paclitaxel44 50 1110.8EGFR, ERBB2, KIT
43rapamycin448.8KIT, EGFR, ERBB2
44doxorubicin44 50 1110.7EGFR, ERBB2, KIT
45paraffin448.4ERBB2, KIT, EGFR, KRT7
46progesterone44 28 61 24 1112.4EGFR, ERBB2, KRT7, KIT
47testosterone44 61 24 1111.4KRT7, KIT, ERBB2, EGFR
48vegf448.4ERBB2, KIT, KRT7, EGFR
49estrogen448.3KIT, KRT7, EGFR, ERBB2
50tyrosine447.7EGFR, KRT7, ERBB2, KIT

GO Terms for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Cellular components related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:0100089.0EGFR, ERBB2
2receptor complexGO:0432358.9EGFR, ERBB2
3basolateral plasma membraneGO:0163238.7EGFR, ERBB2

Biological processes related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:0230149.5KIT, ERBB2
2positive regulation of MAP kinase activityGO:0434069.2ERBB2, EGFR
3positive regulation of epithelial cell proliferationGO:0506799.1EGFR, ERBB2
4positive regulation of protein phosphorylationGO:0019349.0EGFR, ERBB2
5cell surface receptor signaling pathwayGO:0071669.0ERBB2, EGFR
6positive regulation of cell migrationGO:0303358.8EGFR, KIT
7peptidyl-tyrosine phosphorylationGO:0181088.8KIT, ERBB2, EGFR
8phosphatidylinositol-mediated signalingGO:0480158.8KIT, ERBB2, EGFR
9protein autophosphorylationGO:0467778.8EGFR, KIT, ERBB2
10fibroblast growth factor receptor signaling pathwayGO:0085438.8EGFR, ERBB2, KIT
11Fc-epsilon receptor signaling pathwayGO:0380958.8EGFR, ERBB2, KIT
12epidermal growth factor receptor signaling pathwayGO:0071738.7KIT, EGFR, ERBB2
13neurotrophin TRK receptor signaling pathwayGO:0480118.7KIT, EGFR, ERBB2
14innate immune responseGO:0450878.6EGFR, ERBB2, KIT
15signal transductionGO:0071658.4KIT, ERBB2, EGFR

Molecular functions related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.0ERBB2, EGFR
2transmembrane signaling receptor activityGO:0048889.0EGFR, ERBB2
3protein phosphatase bindingGO:0199038.7EGFR, ERBB2
4receptor signaling protein tyrosine kinase activityGO:0047168.6EGFR, ERBB2, KIT
5transmembrane receptor protein tyrosine kinase activityGO:0047148.6EGFR, ERBB2, KIT
6protein tyrosine kinase activityGO:0047138.4EGFR, ERBB2, KIT

Products for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Sources for Sinonasal Undifferentiated Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet