SNUC
MCID: SNN002
MIFTS: 43

Sinonasal Undifferentiated Carcinoma (SNUC) malady

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Summaries for Sinonasal Undifferentiated Carcinoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Sinonasal undifferentiated carcinoma (snuc) is a type of cancer that develops in the sinuses of the head.  snuc occurs when cells from the layer of tissue that lines the sinuses (called the epithelium) rapidly increase in number, forming a mass.  the first symptoms of snuc may include difficulty breathing though the nose or mild facial pain.  as snuc progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face.  snuc is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body (metastasis).  treatment may include surgery, chemotherapy, and radiation therapy. last updated: 1/22/2013

MalaCards: Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to neuroendocrine carcinoma and adenocarcinoma. An important gene associated with Sinonasal Undifferentiated Carcinoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Endocytosis. The compounds ptk787 and zd6474 have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Wikipedia:65 Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare aggressive type of cancer that arises... more...

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

sinonasal undifferentiated carcinoma 43 62
highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses 43
snuc 43


Related Diseases for Sinonasal Undifferentiated Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma30.4KIT, KRT7
2adenocarcinoma30.3ERBB2, KRT7, EGFR
3olfactory neuroblastoma10.4
4nasopharyngitis10.4
5neuroblastoma10.4
6schneiderian carcinoma10.2
7aspergillosis10.2
8neuropathy10.2
9sinusitis10.2
10bronchiolo-alveolar adenocarcinoma10.0EGFR, KRT7
11adenosquamous carcinoma10.0EGFR, KRT7
12mucoepidermoid carcinoma10.0EGFR, KRT7
13thymus cancer10.0KRT7, KIT
14dysgerminoma10.0KIT, KRT7
15malignant peripheral nerve sheath tumor10.0EGFR, KIT
16oxyphilic adenoma10.0KIT, KRT7
17synovial sarcoma10.0KRT7, KIT
18teratoma10.0KIT, KRT7
19mammary paget's disease10.0KRT7, ERBB2
20cutaneous paget's disease10.0KRT7, ERBB2
21biliary tract neoplasm10.0ERBB2, EGFR
22inflammatory breast carcinoma10.0ERBB2, EGFR
23lung benign neoplasm10.0KRT7, EGFR
24ductal carcinoma in situ10.0EGFR, ERBB2
25tubular adenocarcinoma10.0KRT7, ERBB2
26uterine carcinosarcoma10.0ERBB2, KIT
27bladder carcinoma in situ10.0EGFR, ERBB2
28pancreatic cancer10.0EGFR, KRT7
29diarrhea10.0EGFR, ERBB2
30papillary carcinoma10.0KRT7, ERBB2
31cholangiocarcinoma10.0ERBB2, KRT7
32neutropenia10.0EGFR, ERBB2
33gastric adenocarcinoma10.0KRT7, ERBB2
34non-small cell lung carcinoma10.0EGFR, ERBB2
35lung small cell carcinoma10.0EGFR, KRT7, KIT
36breast cancer10.0EGFR, ERBB2
37kidney cancer10.0KIT, KRT7, EGFR
38squamous cell carcinoma of the head and neck10.0EGFR, ERBB2
39large cell carcinoma10.0EGFR, KRT7, ERBB2
40transitional cell carcinoma10.0ERBB2, KRT7, EGFR
41lung adenocarcinoma10.0EGFR, KRT7, ERBB2
42stomach cancer10.0ERBB2, KRT7, EGFR
43cervical cancer10.0EGFR, ERBB2
44lung cancer10.0ERBB2, KRT7, EGFR
45prostate cancer10.0EGFR, KRT7, ERBB2
46malignant mixed mullerian tumor10.0KIT, ERBB2, KRT7
47adenoid cystic carcinoma10.0KIT, ERBB2, KRT7
48factor vii deficiency10.0EGFR, ERBB2, KIT
49ovarian cancer9.9ERBB2, KRT7, EGFR
50colorectal cancer9.9ERBB2, KRT7, EGFR

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to sinonasal undifferentiated carcinoma

Symptoms for Sinonasal Undifferentiated Carcinoma

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Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Sinonasal Undifferentiated Carcinoma

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

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Anatomical Context for Sinonasal Undifferentiated Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

33
Skin, Liver

Animal Models for Sinonasal Undifferentiated Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Sinonasal Undifferentiated Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7KIT, ERBB2, EGFR
2MP:00020068.6EGFR, ERBB2, KIT
3MP:00053678.6EGFR, KRT7, KIT
4MP:00053828.6KIT, ERBB2, EGFR
5MP:00053698.5EGFR, ERBB2, KIT
6MP:00053888.4KIT, ERBB2, EGFR
7MP:00053818.2EGFR, ERBB2, KIT
8MP:00053848.2EGFR, KRT7, ERBB2, KIT

Publications for Sinonasal Undifferentiated Carcinoma

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52PubMed
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Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Treatment outcomes and prognostic factors including human papillomavirus (HPV) for sinonasal undifferentiated carcinoma: A retrospective review. (24421248)
2014
2
Trimodality management of sinonasal undifferentiated carcinoma and review of the literature. (22992621)
2013
3
Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy. (23462605)
2013
4
Radiotherapy for sinonasal undifferentiated carcinoma. (24268566)
2013
5
Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. (23663264)
2013
6
Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers. (23477516)
2013
7
Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma. (23471826)
2013
8
Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. (22476411)
2013
9
Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. (23993024)
2013
10
Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. (22460731)
2012
11
Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. (23032744)
2012
12
Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. (21041001)
2011
13
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). (21805120)
2011
14
Pediatric sinonasal undifferentiated carcinoma: case report and literature review. (21059557)
2010
15
Sinonasal undifferentiated carcinoma: a 13-year experience at a single institution. (20808529)
2010
16
Primary ocular presentation of sinonasal undifferentiated carcinoma. (20090496)
2010
17
Prognostic factors for patients with sinonasal undifferentiated carcinoma. (21225771)
2010
18
Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression. (19283847)
2009
19
Clinical manifestations of sinonasal undifferentiated carcinoma. (20013673)
2009
20
The cytologic features of sinonasal undifferentiated carcinoma and olfactory neuroblastoma. (18285258)
2008
21
Management of sinonasal undifferentiated carcinoma. (18383526)
2008
22
Patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. (18207030)
2008
23
Sinonasal undifferentiated carcinoma with a frozen globe. (18520842)
2008
24
Diagnosis and treatment of sinonasal undifferentiated carcinoma: report of a case and review of the literature. (18571040)
2008
25
Report of a case of sinonasal undifferentiated carcinoma arising in a background of extensive nasal gliomatosis. (17972313)
2008
26
Intracranial sinonasal undifferentiated carcinoma (SNUC) in a child. (16555080)
2006
27
Sinonasal undifferentiated carcinoma of the maxillary sinus. (16545179)
2006
28
Sinonasal undifferentiated carcinoma. (16462499)
2006
29
Sinonasal undifferentiated carcinoma with intracranial extension. (22496625)
2006
30
Sinonasal undifferentiated carcinoma: an update. (16012246)
2005
31
Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. (15900114)
2005
32
Sinonasal undifferentiated carcinoma: case series and literature review. (15124164)
2004
33
Unusual cases involving the CNS and nasal sinuses: Case 2. Sinonasal undifferentiated carcinoma. (14551308)
2003
34
Sinonasal undifferentiated carcinoma: the search for a better outcome. (12172261)
2002
35
Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities. (11859210)
2002
36
Drop metastasis from sinonasal undifferentiated carcinoma: clinical implications. (11458156)
2001
37
Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association. (11176064)
2001
38
Sinonasal undifferentiated carcinoma with orbital invasion: report of three cases. (11476180)
2001
39
Sinonasal undifferentiated carcinoma: a review of the literature. (18350705)
2001
40
Esthesioneuroblastoma and sinonasal undifferentiated carcinoma: impact of histological grading and clinical staging on survival and prognosis. (10942123)
2000
41
Sinonasal undifferentiated carcinoma: a distinctive clinicopathologic entity. (10562893)
1999
42
Sinonasal undifferentiated carcinoma. (9511119)
1998
43
Sinonasal undifferentiated carcinoma: report of two cases and review of the literature. (9503454)
1998
44
Sinonasal undifferentiated carcinoma: a 10-year experience. (8827275)
1996
45
Pathologic quiz case 2. Sinonasal undifferentiated carcinoma (SNUC). (7546592)
1995
46
Sinonasal undifferentiated carcinoma invading the orbit. (7711477)
1994
47
Sinonasal undifferentiated carcinoma: a ray of hope. (8516007)
1993
48
High-dose chemotherapy and autologous marrow transplantation for esthesioneuroblastoma and sinonasal undifferentiated carcinoma. (2658537)
1989
49
Sinonasal undifferentiated carcinoma: a distinctive and highly aggressive neoplasm. (3613787)
1987
50
Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. (2430477)
1986

Variations for Sinonasal Undifferentiated Carcinoma

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Expression for genes affiliated with Sinonasal Undifferentiated Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sinonasal Undifferentiated Carcinoma

Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Sources:
50PathCards, 51PharmGKB, 30KEGG, 61Tocris Bioscience, 38NCBI BioSystems Database, 60Thomson Reuters, 54R&D Systems, 55Reactome, 53QIAGEN, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1KIT, EGFR
29.1EGFR, KIT
3
Show member pathways
9.1EGFR, KIT
49.1EGFR, KRT7
5
Show member pathways
9.0ERBB2, EGFR
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.0EGFR, ERBB2
79.0EGFR, ERBB2
8
Show member pathways
9.0EGFR, ERBB2
99.0ERBB2, EGFR
109.0EGFR, ERBB2
11
Show member pathways
9.0EGFR, ERBB2
12
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.0EGFR, ERBB2
139.0EGFR, ERBB2
14
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.0EGFR, ERBB2
15
Show member pathways
Signaling Pathways in Glioblastoma38
9.0ERBB2, EGFR
169.0EGFR, ERBB2
17
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.0EGFR, ERBB2
18
Show member pathways
9.0ERBB2, EGFR
19
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.0ERBB2, EGFR
209.0EGFR, ERBB2
219.0EGFR, ERBB2
229.0EGFR, ERBB2
239.0EGFR, ERBB2
24
Show member pathways
9.0ERBB2, EGFR
258.5KIT, ERBB2, EGFR
26
Show member pathways
8.5EGFR, ERBB2, KIT
278.5KIT, ERBB2, EGFR
288.5EGFR, ERBB2, KIT
29
Show member pathways
8.5KIT, ERBB2, EGFR
30
Show member pathways
8.5EGFR, ERBB2, KIT
31
Show member pathways
8.5EGFR, ERBB2, KIT
32
Show member pathways
8.5EGFR, ERBB2, KIT
33
Show member pathways
8.5KIT, ERBB2, EGFR
34
Show member pathways
8.5EGFR, ERBB2, KIT
35
Show member pathways
8.5KIT, ERBB2, EGFR
36
Show member pathways
8.5EGFR, ERBB2, KIT
37
Show member pathways
Signal transduction PTEN pathway60
8.5EGFR, ERBB2, KIT
38
Show member pathways
8.5KIT, ERBB2, EGFR
39
Show member pathways
8.5KIT, ERBB2, EGFR
40
Show member pathways
8.5KIT, ERBB2, EGFR
41
Show member pathways
8.5KIT, ERBB2, EGFR
42
Show member pathways
8.5EGFR, ERBB2, KIT
43
Show member pathways
8.5KIT, ERBB2, EGFR

Compounds for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Sources:
45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1ptk787459.5KIT, EGFR
2zd6474459.5KIT, EGFR
3ag-1296459.5EGFR, KIT
4ag 490619.5ERBB2, EGFR
5jnj 28871063 hydrochloride619.4EGFR, ERBB2
6afatinib51 1110.4EGFR, ERBB2
7ag 1478 hydrochloride619.4ERBB2, EGFR
8iressa619.4ERBB2, EGFR
9su5416459.4EGFR, KIT
10pd158780459.4ERBB2, EGFR
11pertuzumab45 51 1111.4ERBB2, EGFR
12pki-166459.4EGFR, ERBB2
13hrgbeta1459.4EGFR, ERBB2
14quinazoline459.4ERBB2, EGFR
15erbstatin459.4EGFR, ERBB2
16anastrozole45 51 1111.3ERBB2, EGFR
17exemestane45 51 61 1112.3ERBB2, EGFR
18pd153035459.3EGFR, ERBB2
19lapatinib45 51 1111.3ERBB2, EGFR
20regorafenib51 1110.2KIT, EGFR
215-methylthioadenosine459.2EGFR, ERBB2
22formaldehyde45 2410.2KRT7, ERBB2, KIT
23fulvestrant45 51 29 1112.2ERBB2, EGFR
24methotrexate51 45 1111.2KRT7, ERBB2, KIT
25dasatinib45 51 1111.1EGFR, KIT
26vinorelbine45 51 1111.1ERBB2, EGFR
27taxane459.0ERBB2, EGFR
28capecitabine45 51 1111.0EGFR, ERBB2, KIT
29everolimus45 51 1111.0EGFR, ERBB2, KIT
30sunitinib45 51 1111.0KIT, ERBB2, EGFR
31erlotinib45 51 1111.0EGFR, ERBB2, KIT
32flavopiridol45 1110.0KIT, ERBB2, EGFR
33trastuzumab45 51 1110.9EGFR, ERBB2, KIT
34gefitinib45 51 1110.9EGFR, ERBB2, KIT
35irinotecan45 51 1110.9EGFR, ERBB2, KIT
36geldanamycin45 51 61 1111.9EGFR, ERBB2, KIT
37letrozole45 51 61 1111.9ERBB2, EGFR
38docetaxel45 51 61 1111.9EGFR, ERBB2, KIT
39imatinib45 51 1110.9KIT, ERBB2, EGFR
405fluorouracil458.8KIT, ERBB2, EGFR
41phosphotyrosine458.8KIT, ERBB2, EGFR
42paclitaxel45 51 1110.8EGFR, ERBB2, KIT
43rapamycin458.8EGFR, ERBB2, KIT
44doxorubicin45 51 1110.7EGFR, ERBB2, KIT
45paraffin458.4EGFR, KRT7, ERBB2, KIT
46progesterone45 29 61 24 1112.4KIT, ERBB2, KRT7, EGFR
47testosterone45 61 24 1111.4KIT, ERBB2, KRT7, EGFR
48vegf458.4KIT, ERBB2, KRT7, EGFR
49estrogen458.3KIT, ERBB2, KRT7, EGFR
50tyrosine457.7KIT, ERBB2, KRT7, EGFR

GO Terms for genes affiliated with Sinonasal Undifferentiated Carcinoma

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16Gene Ontology
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Cellular components related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:0100089.0EGFR, ERBB2
2receptor complexGO:0432358.9EGFR, ERBB2
3basolateral plasma membraneGO:0163238.7EGFR, ERBB2

Biological processes related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:0230149.5ERBB2, KIT
2positive regulation of MAP kinase activityGO:0434069.2EGFR, ERBB2
3positive regulation of epithelial cell proliferationGO:0506799.1EGFR, ERBB2
4positive regulation of protein phosphorylationGO:0019349.0EGFR, ERBB2
5cell surface receptor signaling pathwayGO:0071669.0EGFR, ERBB2
6positive regulation of cell migrationGO:0303358.8EGFR, KIT
7peptidyl-tyrosine phosphorylationGO:0181088.8EGFR, ERBB2, KIT
8phosphatidylinositol-mediated signalingGO:0480158.8KIT, ERBB2, EGFR
9protein autophosphorylationGO:0467778.8EGFR, ERBB2, KIT
10fibroblast growth factor receptor signaling pathwayGO:0085438.8KIT, ERBB2, EGFR
11Fc-epsilon receptor signaling pathwayGO:0380958.8EGFR, ERBB2, KIT
12epidermal growth factor receptor signaling pathwayGO:0071738.7EGFR, ERBB2, KIT
13neurotrophin TRK receptor signaling pathwayGO:0480118.7KIT, ERBB2, EGFR
14innate immune responseGO:0450878.6KIT, ERBB2, EGFR
15signal transductionGO:0071658.4KIT, ERBB2, EGFR

Molecular functions related to Sinonasal Undifferentiated Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.0ERBB2, EGFR
2transmembrane signaling receptor activityGO:0048889.0EGFR, ERBB2
3protein phosphatase bindingGO:0199038.7EGFR, ERBB2
4receptor signaling protein tyrosine kinase activityGO:0047168.6EGFR, ERBB2, KIT
5transmembrane receptor protein tyrosine kinase activityGO:0047148.6EGFR, ERBB2, KIT
6protein tyrosine kinase activityGO:0047138.4EGFR, ERBB2, KIT

Products for genes affiliated with Sinonasal Undifferentiated Carcinoma

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  • Antibodies
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Sources for Sinonasal Undifferentiated Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet