MCID: SNN002
MIFTS: 27

Sinonasal Undifferentiated Carcinoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

MalaCards integrated aliases for Sinonasal Undifferentiated Carcinoma:

Name: Sinonasal Undifferentiated Carcinoma 50 69
Highly Aggressive Undifferentiated Carcinoma of the Nasal Cavity and Paranasal Sinuses 50
Snuc 50

Classifications:



Summaries for Sinonasal Undifferentiated Carcinoma

NIH Rare Diseases : 50 sinonasal undifferentiated carcinoma (snuc) is a type of cancer that develops in the sinuses of the head. snuc occurs when cells from the layer of tissue that lines the sinuses (called the epithelium) rapidly increase in number, forming a mass. the first symptoms of snuc may include difficulty breathing though the nose or mild facial pain. as snuc progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face. snuc is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body (metastasis). the cause of snuc is still unknown. when possible, the treatment is the complete removal of the tumor, combined with radiation therapy and chemotherapy. in cases where the tumor can't be removed completely, the treatment is with radiation and chemotherapy. the risk of the tumor coming back (relapse) is high and the probability of cure is modest. last updated: 11/10/2016

MalaCards based summary : Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to olfactory neuroblastoma and paranasal sinus cancer. An important gene associated with Sinonasal Undifferentiated Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways is Neuroscience. The drugs Cisplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord.

Wikipedia : 72 Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare aggressive type of cancer that arises... more...

Related Diseases for Sinonasal Undifferentiated Carcinoma

Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
id Related Disease Score Top Affiliating Genes
1 olfactory neuroblastoma 30.4 ENO2 SYP
2 paranasal sinus cancer 10.4 ENO2 SYP
3 ampulla of vater small cell carcinoma 10.4 ENO2 SYP
4 childhood choriocarcinoma of the ovary 10.4 ENO2 SYP
5 glomus tumor 10.4 ENO2 SYP
6 osteoblastoma 10.4 ENO2 SYP
7 cystitis cystica 10.4 ENO2 SYP
8 small intestine cancer, childhood 10.4 ENO2 SYP
9 pemphigus foliaceus 10.4 ENO2 SYP
10 gallbladder adenocarcinoma 10.4 ENO2 SYP
11 chondroid chordoma 10.4 ENO2 SYP
12 skin papilloma 10.4 ENO2 SYP
13 congenital granular cell tumor 10.4 ENO2 SYP
14 brain glioma 10.4 ENO2 SYP
15 mast cell neoplasm 10.4 ENO2 SYP
16 hair disease 10.4 ENO2 SYP
17 cauda equina intradural extramedullary astrocytoma 10.4 ENO2 SYP
18 rh isoimmunization 10.4 ENO2 SYP
19 pleomorphic xanthoastrocytoma 10.4 ENO2 SYP
20 thymus large cell carcinoma 10.4 ENO2 SYP
21 cauda equina neoplasm 10.4 ENO2 SYP
22 mature teratoma 10.4 ENO2 SYP
23 axonal neuropathy 10.4 ENO2 SYP
24 childhood choroid plexus cancer 10.4 ENO2 SYP
25 brachial plexus neuritis 10.4 ENO2 SYP
26 malignant granular cell myoblastoma 10.4 ENO2 SYP
27 thymus small cell carcinoma 10.4 ENO2 SYP
28 behcet's syndrome arthropathy 10.4 ENO2 SYP
29 sudden sensorineural hearing loss 10.4 ENO2 SYP
30 pineoblastoma 10.4 ENO2 SYP
31 olfactory neural tumor 10.4 ENO2 SYP
32 pituitary dwarfism with large sella turcica 10.4 ENO2 SYP
33 sensory organ benign neoplasm 10.4 ENO2 SYP
34 encephalitozoonosis 10.4 ENO2 SYP
35 pneumonia 10.4 ENO2 SYP
36 ethmoid sinus schneiderian papilloma 10.4 ENO2 SYP
37 urethra clear cell adenocarcinoma 10.4 ENO2 SYP
38 pancreatic agenesis 10.4 ENO2 SYP
39 nose disease 10.4 ENO2 SYP
40 cowden syndrome 3 10.4 ENO2 SYP
41 alpha chain disease 10.4 ENO2 SYP
42 pediatric ependymoma 10.3 ENO2 SYP
43 human t-cell leukemia virus type 1 10.3 ENO2 SYP
44 glomangioma 10.3 ENO2 SYP
45 extracutaneous mastocytoma 10.3 ENO2 SYP
46 mixed epithelial stromal tumour 10.3 ENO2 SYP
47 calcific tendinitis 10.3 ENO2 SYP
48 hypersensitivity reaction type iii disease 10.3 ENO2 SYP
49 childhood ovarian endodermal sinus tumor 10.3 ENO2 SYP
50 carcinoma of unknown primary site, childhood 10.3 ENO2 SYP

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to Sinonasal Undifferentiated Carcinoma

Symptoms & Phenotypes for Sinonasal Undifferentiated Carcinoma

Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

Drugs for Sinonasal Undifferentiated Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Fluorouracil Approved Phase 2 51-21-8 3385
5
Ifosfamide Approved Phase 2 3778-73-2 3690
6
Mechlorethamine Approved Phase 2 51-75-2 4033
7
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
8
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
9
Doxil Approved June 1999 Phase 2 31703
10 Alkylating Agents Phase 2
11 Anti-Bacterial Agents Phase 2
12 Antibiotics, Antitubercular Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Antimitotic Agents Phase 2
16 Antineoplastic Agents, Phytogenic Phase 2
17 Etoposide phosphate Phase 2
18 Immunosuppressive Agents Phase 2
19 Isophosphamide mustard Phase 2
20 Pharmaceutical Solutions Phase 2
21 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Inoperable Patients Recruiting NCT02099188 Phase 2 Cisplatin;Docetaxel;5-fluorouracil;Etoposide;Adriamycin;Ifosfamide;Leucovorin
2 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Operable Patients Recruiting NCT02099175 Phase 2 Cisplatin;Docetaxel;5-fluorouracil;Etoposide;Adriamycin;Ifosfamide;Leucovorin
3 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

Anatomical Context for Sinonasal Undifferentiated Carcinoma

MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

39
Skin, Liver, Spinal Cord

Publications for Sinonasal Undifferentiated Carcinoma

Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50) (show all 88)
id Title Authors Year
1
A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience. ( 27938440 )
2017
2
Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience. ( 28561906 )
2017
3
Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma. ( 28084339 )
2017
4
Spinal Cord Compression Secondary to Metastatic Sinonasal Undifferentiated Carcinoma. ( 28868018 )
2017
5
Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma. ( 27703092 )
2017
6
Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature. ( 26829682 )
2016
7
Significance of Tumor Stage in Sinonasal Undifferentiated Carcinoma Survival: A Population-Based Analysis. ( 26908559 )
2016
8
Pre-operative chemoradiation for sinonasal undifferentiated carcinoma of the anterior nasal cavity resected through a lateral nasal flap approach. ( 26954865 )
2016
9
Role of (18) F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma. ( 27481043 )
2016
10
Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database. ( 27717204 )
2016
11
Sinonasal Undifferentiated Carcinoma Presenting With Bilateral Compressive Optic Neuropathy. ( 27281738 )
2016
12
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma. ( 26752332 )
2016
13
Sinonasal undifferentiated carcinoma as a third primary neoplasm: A case report and review of the literature. ( 25923276 )
2015
14
Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. ( 25844294 )
2015
15
Current management of sinonasal undifferentiated carcinoma. ( 26363162 )
2015
16
Reappraisal of sinonasal undifferentiated carcinoma: SMARCB1 (INI1)-deficient sinonasal carcinoma: a single-institution experience. ( 26407663 )
2015
17
Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation. ( 25685767 )
2015
18
Nodal Metastasis and Elective Nodal Level Treatment in Sinonasal Small Cell and Sinonasal Undifferentiated Carcinoma: A Surveillance, Epidemiology and End Results Analysis. ( 26559439 )
2015
19
Esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma: differentiation in diagnosis and treatment. ( 25992139 )
2014
20
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma. ( 25017972 )
2014
21
Molecular profiling of sinonasal undifferentiated carcinoma. ( 23633104 )
2014
22
Treatment outcomes and prognostic factors including human papillomavirus (HPV) for sinonasal undifferentiated carcinoma: A retrospective review. ( 24421248 )
2014
23
Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers. ( 23477516 )
2013
24
Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. ( 23993024 )
2013
25
Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma. ( 23471826 )
2013
26
Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. ( 23663264 )
2013
27
Trimodality management of sinonasal undifferentiated carcinoma and review of the literature. ( 22992621 )
2013
28
Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy. ( 23462605 )
2013
29
Radiotherapy for sinonasal undifferentiated carcinoma. ( 24268566 )
2013
30
Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. ( 22476411 )
2013
31
Sinonasal undifferentiated carcinoma and esthesioneuroblastoma recurring as nonintestinal adenocarcinoma. ( 23553283 )
2013
32
Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. ( 23032744 )
2012
33
Sinonasal undifferentiated carcinoma presenting as recurrent fronto-ethmoidal pyomucocele. ( 23251060 )
2012
34
Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. ( 22460731 )
2012
35
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). ( 21805120 )
2011
36
Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. ( 21041001 )
2011
37
Primary ocular presentation of sinonasal undifferentiated carcinoma. ( 20090496 )
2010
38
Sinonasal undifferentiated carcinoma: a 13-year experience at a single institution. ( 20808529 )
2010
39
Pediatric sinonasal undifferentiated carcinoma: case report and literature review. ( 21059557 )
2010
40
Prognostic factors for patients with sinonasal undifferentiated carcinoma. ( 21225771 )
2010
41
Sinonasal undifferentiated carcinoma metastatic to the skin. ( 19682175 )
2010
42
Sinonasal undifferentiated carcinoma, or schneiderian carcinoma arising from an aspergillosis: a case history. ( 19211176 )
2009
43
Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression. ( 19283847 )
2009
44
Clinical manifestations of sinonasal undifferentiated carcinoma. ( 20013673 )
2009
45
Report of a case of sinonasal undifferentiated carcinoma arising in a background of extensive nasal gliomatosis. ( 17972313 )
2008
46
Management of sinonasal undifferentiated carcinoma. ( 18383526 )
2008
47
Liver transplantation for metastatic sinonasal undifferentiated carcinoma: a case report. ( 19100503 )
2008
48
Sinonasal undifferentiated carcinoma with a frozen globe. ( 18520842 )
2008
49
Diagnosis and treatment of sinonasal undifferentiated carcinoma: report of a case and review of the literature. ( 18571040 )
2008
50
Patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. ( 18207030 )
2008

Variations for Sinonasal Undifferentiated Carcinoma

Expression for Sinonasal Undifferentiated Carcinoma

Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for Sinonasal Undifferentiated Carcinoma

Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.31 ENO2 MKI67 SYP

GO Terms for Sinonasal Undifferentiated Carcinoma

Sources for Sinonasal Undifferentiated Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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