MCID: SNN002
MIFTS: 37

Sinonasal Undifferentiated Carcinoma malady

Rare diseases, Cancer diseases categories

Summaries for Sinonasal Undifferentiated Carcinoma

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NIH Rare Diseases:41 Sinonasal undifferentiated carcinoma (snuc) is a type of cancer that develops in the sinuses of the head.  snuc occurs when cells from the layer of tissue that lines the sinuses (called the epithelium) rapidly increase in number, forming a mass.  the first symptoms of snuc may include difficulty breathing though the nose or mild facial pain.  as snuc progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face.  snuc is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body (metastasis).  treatment may include surgery, chemotherapy, and radiation therapy. last updated: 1/22/2013

MalaCards based summary: Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to adenocarcinoma and neuroblastoma. An important gene associated with Sinonasal Undifferentiated Carcinoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Endocytosis. The compounds ptk787 and zd6474 have been mentioned in the context of this disorder. Affiliated tissues include liver and skin, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Wikipedia:63 Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare aggressive type of cancer that arises... more...

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

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Sinonasal Undifferentiated Carcinoma, Aliases & Descriptions:

Name: Sinonasal Undifferentiated Carcinoma 41 60
Highly Aggressive Undifferentiated Carcinoma of the Nasal Cavity and Paranasal Sinuses 41
 
Snuc 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Sinonasal Undifferentiated Carcinoma

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Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.0ERBB2, KRT7, EGFR
2neuroblastoma10.4
3olfactory neuroblastoma10.4
4nasopharyngitis10.4
5aspergillosis10.3
6sinusitis10.3
7neuroendocrine carcinoma10.3
8schneiderian carcinoma10.3
9neuropathy10.3
10renal cell carcinoma10.2EGFR, KRT7
11bronchiolo-alveolar adenocarcinoma10.2EGFR, KRT7
12adenosquamous carcinoma10.2EGFR, KRT7
13mucoepidermoid carcinoma10.2EGFR, KRT7
14thymic carcinoma10.1KRT7, KIT
15dysgerminoma10.1KIT, KRT7
16malignant peripheral nerve sheath tumor10.1EGFR, KIT
17neuroendocrine tumor10.1KIT, KRT7
18oxyphilic adenoma10.1KIT, KRT7
19sarcoma, synovial10.1KRT7, KIT
20teratoma10.1KIT, KRT7
21mammary paget's disease10.1KRT7, ERBB2
22paget disease, extramammary10.1KRT7, ERBB2
23biliary tract neoplasm10.1ERBB2, EGFR
24inflammatory breast carcinoma10.1ERBB2, EGFR
25lung benign neoplasm10.1KRT7, EGFR
26ductal carcinoma in situ10.0EGFR, ERBB2
27tubular adenocarcinoma10.0KRT7, ERBB2
28breast ductal carcinoma10.0EGFR, ERBB2
29uterine carcinosarcoma10.0ERBB2, KIT
30bladder cancer, somatic10.0EGFR, ERBB2
31pancreatic cancer10.0EGFR, KRT7
32diarrhea10.0EGFR, ERBB2
33papillary carcinoma10.0KRT7, ERBB2
34cholangiocarcinoma10.0ERBB2, KRT7
35neutropenia10.0EGFR, ERBB2
36gastric adenocarcinoma10.0KRT7, ERBB2
37lung cancer9.9EGFR, ERBB2
38small cell cancer of the lung, somatic9.9EGFR, KRT7, KIT
39breast cancer9.9EGFR, ERBB2
40kidney cancer9.9KIT, KRT7, EGFR
41squamous cell carcinoma, head and neck9.9EGFR, ERBB2
42large cell carcinoma9.8EGFR, KRT7, ERBB2
43transitional cell carcinoma9.8ERBB2, KRT7, EGFR
44lung cancer susceptibility 39.8EGFR, KRT7, ERBB2
45stomach cancer9.8ERBB2, KRT7, EGFR
46cervical cancer, somatic9.8EGFR, ERBB2
47prostate cancer9.8EGFR, KRT7, ERBB2
48malignant mixed mullerian tumor9.8KIT, ERBB2, KRT7
49salivary gland adenoid cystic carcinoma9.8KIT, ERBB2, KRT7
50factor vii deficiency9.8EGFR, ERBB2, KIT

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to sinonasal undifferentiated carcinoma

Symptoms for Sinonasal Undifferentiated Carcinoma

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Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Sinonasal Undifferentiated Carcinoma

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

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Anatomical Context for Sinonasal Undifferentiated Carcinoma

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MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

31
Liver, Skin

Animal Models for Sinonasal Undifferentiated Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Sinonasal Undifferentiated Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7KIT, ERBB2, EGFR
2MP:00020068.6EGFR, ERBB2, KIT
3MP:00053678.6EGFR, KRT7, KIT
4MP:00053828.6KIT, ERBB2, EGFR
5MP:00053698.5EGFR, ERBB2, KIT
6MP:00053888.4KIT, ERBB2, EGFR
7MP:00053818.2EGFR, ERBB2, KIT
8MP:00053848.2EGFR, KRT7, ERBB2, KIT

Publications for Sinonasal Undifferentiated Carcinoma

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Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation. (25685767)
2015
2
Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. (25844294)
2015
3
Treatment outcomes and prognostic factors including human papillomavirus (HPV) for sinonasal undifferentiated carcinoma: A retrospective review. (24421248)
2014
4
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma. (25017972)
2014
5
Trimodality management of sinonasal undifferentiated carcinoma and review of the literature. (22992621)
2013
6
Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy. (23462605)
2013
7
Radiotherapy for sinonasal undifferentiated carcinoma. (24268566)
2013
8
Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. (23663264)
2013
9
Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers. (23477516)
2013
10
Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma. (23471826)
2013
11
Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. (22476411)
2013
12
Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. (23993024)
2013
13
Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. (22460731)
2012
14
Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. (23032744)
2012
15
Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. (21041001)
2011
16
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). (21805120)
2011
17
Pediatric sinonasal undifferentiated carcinoma: case report and literature review. (21059557)
2010
18
Sinonasal undifferentiated carcinoma: a 13-year experience at a single institution. (20808529)
2010
19
Primary ocular presentation of sinonasal undifferentiated carcinoma. (20090496)
2010
20
Prognostic factors for patients with sinonasal undifferentiated carcinoma. (21225771)
2010
21
Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression. (19283847)
2009
22
Clinical manifestations of sinonasal undifferentiated carcinoma. (20013673)
2009
23
The cytologic features of sinonasal undifferentiated carcinoma and olfactory neuroblastoma. (18285258)
2008
24
Management of sinonasal undifferentiated carcinoma. (18383526)
2008
25
Patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. (18207030)
2008
26
Sinonasal undifferentiated carcinoma with a frozen globe. (18520842)
2008
27
Diagnosis and treatment of sinonasal undifferentiated carcinoma: report of a case and review of the literature. (18571040)
2008
28
Intracranial sinonasal undifferentiated carcinoma (SNUC) in a child. (16555080)
2006
29
Sinonasal undifferentiated carcinoma of the maxillary sinus. (16545179)
2006
30
Sinonasal undifferentiated carcinoma. (16462499)
2006
31
Sinonasal undifferentiated carcinoma: an update. (16012246)
2005
32
Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. (15900114)
2005
33
Sinonasal undifferentiated carcinoma: case series and literature review. (15124164)
2004
34
Unusual cases involving the CNS and nasal sinuses: Case 2. Sinonasal undifferentiated carcinoma. (14551308)
2003
35
Sinonasal undifferentiated carcinoma: the search for a better outcome. (12172261)
2002
36
Sinonasal undifferentiated carcinoma and nasopharyngeal-type undifferentiated carcinoma: two clinically, biologically, and histopathologically distinct entities. (11859210)
2002
37
Drop metastasis from sinonasal undifferentiated carcinoma: clinical implications. (11458156)
2001
38
Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association. (11176064)
2001
39
Sinonasal undifferentiated carcinoma with orbital invasion: report of three cases. (11476180)
2001
40
Esthesioneuroblastoma and sinonasal undifferentiated carcinoma: impact of histological grading and clinical staging on survival and prognosis. (10942123)
2000
41
Sinonasal undifferentiated carcinoma: a distinctive clinicopathologic entity. (10562893)
1999
42
Sinonasal undifferentiated carcinoma. (9511119)
1998
43
Sinonasal undifferentiated carcinoma: report of two cases and review of the literature. (9503454)
1998
44
Sinonasal undifferentiated carcinoma: a 10-year experience. (8827275)
1996
45
Pathologic quiz case 2. Sinonasal undifferentiated carcinoma (SNUC). (7546592)
1995
46
Sinonasal undifferentiated carcinoma invading the orbit. (7711477)
1994
47
Sinonasal undifferentiated carcinoma: a ray of hope. (8516007)
1993
48
High-dose chemotherapy and autologous marrow transplantation for esthesioneuroblastoma and sinonasal undifferentiated carcinoma. (2658537)
1989
49
Sinonasal undifferentiated carcinoma: a distinctive and highly aggressive neoplasm. (3613787)
1987
50
Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. (2430477)
1986

Variations for Sinonasal Undifferentiated Carcinoma

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Expression for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1KIT, EGFR
29.1EGFR, KIT
3
Show member pathways
9.1EGFR, KIT
49.1EGFR, KRT7
5
Show member pathways
9.0ERBB2, EGFR
6
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.0EGFR, ERBB2
79.0EGFR, ERBB2
8
Show member pathways
9.0EGFR, ERBB2
99.0ERBB2, EGFR
109.0EGFR, ERBB2
11
Show member pathways
9.0EGFR, ERBB2
12
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.0EGFR, ERBB2
139.0EGFR, ERBB2
14
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.0EGFR, ERBB2
15
Show member pathways
Signaling Pathways in Glioblastoma36
9.0ERBB2, EGFR
169.0EGFR, ERBB2
17
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.0EGFR, ERBB2
18
Show member pathways
9.0ERBB2, EGFR
19
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.0ERBB2, EGFR
209.0EGFR, ERBB2
219.0EGFR, ERBB2
229.0EGFR, ERBB2
239.0EGFR, ERBB2
24
Show member pathways
9.0ERBB2, EGFR
258.5KIT, ERBB2, EGFR
26
Show member pathways
8.5EGFR, ERBB2, KIT
278.5KIT, ERBB2, EGFR
288.5EGFR, ERBB2, KIT
29
Show member pathways
8.5KIT, ERBB2, EGFR
30
Show member pathways
8.5EGFR, ERBB2, KIT
31
Show member pathways
8.5EGFR, ERBB2, KIT
32
Show member pathways
8.5EGFR, ERBB2, KIT
33
Show member pathways
8.5KIT, ERBB2, EGFR
34
Show member pathways
8.5EGFR, ERBB2, KIT
35
Show member pathways
8.5KIT, ERBB2, EGFR
36
Show member pathways
8.5EGFR, ERBB2, KIT
37
Show member pathways
Signal transduction PTEN pathway58
8.5EGFR, ERBB2, KIT
38
Show member pathways
8.5KIT, ERBB2, EGFR
39
Show member pathways
8.5KIT, ERBB2, EGFR
40
Show member pathways
8.5KIT, ERBB2, EGFR
41
Show member pathways
8.5KIT, ERBB2, EGFR
42
Show member pathways
8.5EGFR, ERBB2, KIT
43
Show member pathways
8.5KIT, ERBB2, EGFR

Compounds for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Compounds related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1ptk787439.5KIT, EGFR
2zd6474439.5KIT, EGFR
3ag-1296439.5EGFR, KIT
4ag 490599.5ERBB2, EGFR
5jnj 28871063 hydrochloride599.4EGFR, ERBB2
6afatinib49 1210.4EGFR, ERBB2
7ag 1478 hydrochloride599.4ERBB2, EGFR
8iressa599.4ERBB2, EGFR
9su5416439.4EGFR, KIT
10pd158780439.4ERBB2, EGFR
11pertuzumab43 49 1211.4ERBB2, EGFR
12pki-166439.4EGFR, ERBB2
13hrgbeta1439.4EGFR, ERBB2
14quinazoline439.4ERBB2, EGFR
15erbstatin439.4EGFR, ERBB2
16anastrozole43 49 1211.3ERBB2, EGFR
17exemestane43 49 59 1212.3ERBB2, EGFR
18pd153035439.3EGFR, ERBB2
19lapatinib43 49 1211.3ERBB2, EGFR
20regorafenib49 1210.2KIT, EGFR
215-methylthioadenosine439.2EGFR, ERBB2
22formaldehyde43 2410.2KRT7, ERBB2, KIT
23fulvestrant43 49 28 1212.2ERBB2, EGFR
24methotrexate49 43 1211.2KRT7, ERBB2, KIT
25dasatinib43 49 1211.1EGFR, KIT
26vinorelbine43 49 1211.1ERBB2, EGFR
27taxane439.0ERBB2, EGFR
28capecitabine43 49 1211.0EGFR, ERBB2, KIT
29everolimus43 49 1211.0EGFR, ERBB2, KIT
30sunitinib43 49 1211.0KIT, ERBB2, EGFR
31erlotinib43 49 1211.0EGFR, ERBB2, KIT
32flavopiridol43 1210.0KIT, ERBB2, EGFR
33trastuzumab43 49 1210.9EGFR, ERBB2, KIT
34gefitinib43 49 1210.9EGFR, ERBB2, KIT
35irinotecan43 49 1210.9EGFR, ERBB2, KIT
36geldanamycin43 49 59 1211.9EGFR, ERBB2, KIT
37letrozole43 49 59 1211.9ERBB2, EGFR
38docetaxel43 49 59 1211.9EGFR, ERBB2, KIT
39imatinib43 49 1210.9KIT, ERBB2, EGFR
405fluorouracil438.8KIT, ERBB2, EGFR
41phosphotyrosine438.8KIT, ERBB2, EGFR
42paclitaxel43 49 1210.8EGFR, ERBB2, KIT
43rapamycin438.8EGFR, ERBB2, KIT
44doxorubicin43 49 1210.7EGFR, ERBB2, KIT
45paraffin438.4EGFR, KRT7, ERBB2, KIT
46progesterone43 28 59 24 1212.4KIT, ERBB2, KRT7, EGFR
47testosterone43 59 24 1211.4KIT, ERBB2, KRT7, EGFR
48vegf438.4KIT, ERBB2, KRT7, EGFR
49estrogen438.3KIT, ERBB2, KRT7, EGFR
50tyrosine437.7KIT, ERBB2, KRT7, EGFR

GO Terms for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Cellular components related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endosome membraneGO:00100089.0EGFR, ERBB2
2receptor complexGO:00432358.9EGFR, ERBB2
3basolateral plasma membraneGO:00163238.7EGFR, ERBB2

Biological processes related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1signal transduction by phosphorylationGO:00230149.5ERBB2, KIT
2positive regulation of MAP kinase activityGO:00434069.2EGFR, ERBB2
3positive regulation of epithelial cell proliferationGO:00506799.1EGFR, ERBB2
4positive regulation of protein phosphorylationGO:00019349.0EGFR, ERBB2
5cell surface receptor signaling pathwayGO:00071669.0EGFR, ERBB2
6positive regulation of cell migrationGO:00303358.8EGFR, KIT
7peptidyl-tyrosine phosphorylationGO:00181088.8EGFR, ERBB2, KIT
8phosphatidylinositol-mediated signalingGO:00480158.8KIT, ERBB2, EGFR
9protein autophosphorylationGO:00467778.8EGFR, ERBB2, KIT
10fibroblast growth factor receptor signaling pathwayGO:00085438.8KIT, ERBB2, EGFR
11Fc-epsilon receptor signaling pathwayGO:00380958.8EGFR, ERBB2, KIT
12epidermal growth factor receptor signaling pathwayGO:00071738.7EGFR, ERBB2, KIT
13neurotrophin TRK receptor signaling pathwayGO:00480118.7KIT, ERBB2, EGFR
14innate immune responseGO:00450878.6KIT, ERBB2, EGFR
15signal transductionGO:00071658.4KIT, ERBB2, EGFR

Molecular functions related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00050069.0ERBB2, EGFR
2transmembrane signaling receptor activityGO:00048889.0EGFR, ERBB2
3protein phosphatase bindingGO:00199038.7EGFR, ERBB2
4receptor signaling protein tyrosine kinase activityGO:00047168.6EGFR, ERBB2, KIT
5transmembrane receptor protein tyrosine kinase activityGO:00047148.6EGFR, ERBB2, KIT
6protein tyrosine kinase activityGO:00047138.4EGFR, ERBB2, KIT

Products for genes affiliated with Sinonasal Undifferentiated Carcinoma

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Sources for Sinonasal Undifferentiated Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet