MCID: SNN002
MIFTS: 31

Sinonasal Undifferentiated Carcinoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Sinonasal Undifferentiated Carcinoma

MalaCards integrated aliases for Sinonasal Undifferentiated Carcinoma:

Name: Sinonasal Undifferentiated Carcinoma 49 69
Highly Aggressive Undifferentiated Carcinoma of the Nasal Cavity and Paranasal Sinuses 49
Snuc 49

Classifications:



External Ids:

UMLS 69 C1710096

Summaries for Sinonasal Undifferentiated Carcinoma

NIH Rare Diseases : 49 Sinonasal undifferentiated carcinoma (SNUC) is a type of cancer that develops in the sinuses of the head. SNUC occurs when cells from the layer of tissue that lines the sinuses (called the epithelium) rapidly increase in number, forming a mass. The first symptoms of SNUC may include difficulty breathing though the nose or mild facial pain. As SNUC progresses, other symptoms may include nosebleeds, facial numbness, or tingling in the face. SNUC is an aggressive cancer, meaning it grows rapidly and has a tendency to spread into healthy tissues nearby and to more distant parts of the body (metastasis). The cause of SNUC is still unknown. When possible, the treatment is the complete removal of the tumor, combined with radiation therapy and chemotherapy. In cases where the tumor can't be removed completely, the treatment is with radiation and chemotherapy. The risk of the tumor coming back (relapse) is high and the probability of cure is modest. Last updated: 11/10/2016

MalaCards based summary : Sinonasal Undifferentiated Carcinoma, also known as highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses, is related to olfactory neuroblastoma and malignant sertoli cell tumor. An important gene associated with Sinonasal Undifferentiated Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways is Neuroscience. The drugs Doxorubicin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord.

Wikipedia : 72 Sinonasal undifferentiated carcinoma, abbreviated SNUC, is a rare aggressive type of cancer that arises... more...

Related Diseases for Sinonasal Undifferentiated Carcinoma

Diseases related to Sinonasal Undifferentiated Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 olfactory neuroblastoma 30.4 ENO2 SYP
2 malignant sertoli cell tumor 10.3 ENO2 SYP
3 urinary bladder small cell neuroendocrine carcinoma 10.3 ENO2 SYP
4 auditory system cancer 10.3 ENO2 SYP
5 cutaneous ganglioneuroma 10.3 ENO2 SYP
6 sensory organ benign neoplasm 10.3 ENO2 SYP
7 gallbladder small cell carcinoma 10.3 ENO2 SYP
8 pancreatic somatostatinoma 10.3 ENO2 SYP
9 extrahepatic bile duct adenocarcinoma 10.3 ENO2 SYP
10 small cell carcinoma of the bladder 10.3 ENO2 SYP
11 orbital cancer 10.2 ENO2 SYP
12 ovarian carcinosarcoma 10.2 ENO2 SYP
13 pulmonary large cell neuroendocrine carcinoma 10.2 ENO2 SYP
14 atypical follicular adenoma 10.2 ENO2 SYP
15 central nervous system primitive neuroectodermal neoplasm 10.2 ENO2 SYP
16 cerebellum cancer 10.2 ENO2 SYP
17 subependymal glioma 10.2 ENO2 SYP
18 olfactory nerve neoplasm 10.2 ENO2 SYP
19 cerebral neuroblastoma 10.2 ENO2 SYP
20 cauda equina neoplasm 10.2 ENO2 SYP
21 extraosseous chondrosarcoma 10.2 ENO2 SYP
22 benign ependymoma 10.2 ENO2 SYP
23 malignant teratoma 10.2 ENO2 SYP
24 astroblastoma 10.2 ENO2 SYP
25 cerebral ventricle cancer 10.2 ENO2 SYP
26 cerebrum cancer 10.2 ENO2 SYP
27 pineal gland cancer 10.2 ENO2 SYP
28 endometrial small cell carcinoma 10.2 ENO2 SYP
29 melanotic neuroectodermal tumor 10.2 ENO2 SYP
30 subependymoma 10.2 ENO2 SYP
31 supratentorial cancer 10.2 ENO2 SYP
32 pineocytoma 10.2 ENO2 SYP
33 angiomyoma 10.2 ENO2 SYP
34 gastric squamous cell carcinoma 10.2 ENO2 SYP
35 gastric small cell carcinoma 10.2 ENO2 SYP
36 small cell neuroendocrine carcinoma 10.2 ENO2 SYP
37 bone benign neoplasm 10.2 ENO2 SYP
38 meningeal melanomatosis 10.2 ENO2 SYP
39 carcinoid tumors, intestinal 10.2 ENO2 SYP
40 cervical clear cell adenocarcinoma 10.2 ENO2 SYP
41 papillary ependymoma 10.2 ENO2 SYP
42 cranial nerve malignant neoplasm 10.2 ENO2 SYP
43 connective tissue benign neoplasm 10.2 ENO2 SYP
44 adenoma of the pancreas 10.2 CEACAM3 SYP
45 glomus tumor 10.2 ENO2 SYP
46 intraocular retinoblastoma 10.2 ENO2 SYP
47 subependymal giant cell astrocytoma 10.2 ENO2 SYP
48 central neurocytoma 10.2 ENO2 SYP
49 mixed cell type cancer 10.2 ENO2 SYP
50 carcinoid syndrome 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Sinonasal Undifferentiated Carcinoma:



Diseases related to Sinonasal Undifferentiated Carcinoma

Symptoms & Phenotypes for Sinonasal Undifferentiated Carcinoma

Drugs & Therapeutics for Sinonasal Undifferentiated Carcinoma

Drugs for Sinonasal Undifferentiated Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Ifosfamide Approved Phase 2 3778-73-2 3690
5
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
6
Fluorouracil Approved Phase 2 51-21-8 3385
7
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
8
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
9
Doxil Approved June 1999 Phase 2 31703
10 Isophosphamide mustard Phase 2 0
11 Alkylating Agents Phase 2
12 Topoisomerase Inhibitors Phase 2
13 Anti-Bacterial Agents Phase 2
14 Pharmaceutical Solutions Phase 2
15 Etoposide phosphate Phase 2
16 Immunosuppressive Agents Phase 2
17 Antimetabolites Phase 2
18 Antimetabolites, Antineoplastic Phase 2
19 Antimitotic Agents Phase 2
20 Antibiotics, Antitubercular Phase 2
21 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Inoperable Patients Recruiting NCT02099188 Phase 2 Cisplatin;Docetaxel;5-fluorouracil;Etoposide;Adriamycin;Ifosfamide;Leucovorin
2 Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Operable Patients Recruiting NCT02099175 Phase 2 Cisplatin;Docetaxel;5-fluorouracil;Etoposide;Adriamycin;Ifosfamide;Leucovorin
3 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2

Search NIH Clinical Center for Sinonasal Undifferentiated Carcinoma

Genetic Tests for Sinonasal Undifferentiated Carcinoma

Anatomical Context for Sinonasal Undifferentiated Carcinoma

MalaCards organs/tissues related to Sinonasal Undifferentiated Carcinoma:

38
Skin, Liver, Spinal Cord

Publications for Sinonasal Undifferentiated Carcinoma

Articles related to Sinonasal Undifferentiated Carcinoma:

(show top 50) (show all 91)
# Title Authors Year
1
Spinal Cord Compression Secondary to Metastatic Sinonasal Undifferentiated Carcinoma. ( 28868018 )
2017
2
Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma. ( 27703092 )
2017
3
Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma. ( 28084339 )
2017
4
Outcomes and patterns of failure for sinonasal undifferentiated carcinoma (SNUC): The Mayo Clinic Experience. ( 28561906 )
2017
5
Sinonasal undifferentiated carcinoma originating from inverted papilloma: A case report. ( 29137081 )
2017
6
Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): A case-series, systematic review and meta-analysis. ( 29224819 )
2017
7
Long-term follow-up of a patient with malignant transformation of inverted papilloma into sinonasal undifferentiated carcinoma. ( 29070275 )
2017
8
A multimodality approach to sinonasal undifferentiated carcinoma: a single institute experience. ( 27938440 )
2017
9
Pre-operative chemoradiation for sinonasal undifferentiated carcinoma of the anterior nasal cavity resected through a lateral nasal flap approach. ( 26954865 )
2016
10
Sinonasal Undifferentiated Carcinoma Presenting With Bilateral Compressive Optic Neuropathy. ( 27281738 )
2016
11
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma. ( 26752332 )
2016
12
Management of sinonasal undifferentiated carcinoma with intracerebral invasion: Clinical experience at a single institution and review of the literature. ( 26829682 )
2016
13
Treatment modalities in sinonasal undifferentiated carcinoma: an analysis from the national cancer database. ( 27717204 )
2016
14
Significance of Tumor Stage in Sinonasal Undifferentiated Carcinoma Survival: A Population-Based Analysis. ( 26908559 )
2016
15
Role of (18) F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma. ( 27481043 )
2016
16
Incidence and survival patterns of sinonasal undifferentiated carcinoma in the United States. ( 25844294 )
2015
17
Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation. ( 25685767 )
2015
18
Nodal Metastasis and Elective Nodal Level Treatment in Sinonasal Small Cell and Sinonasal Undifferentiated Carcinoma: A Surveillance, Epidemiology and End Results Analysis. ( 26559439 )
2015
19
Sinonasal undifferentiated carcinoma as a third primary neoplasm: A case report and review of the literature. ( 25923276 )
2015
20
Current management of sinonasal undifferentiated carcinoma. ( 26363162 )
2015
21
Reappraisal of sinonasal undifferentiated carcinoma: SMARCB1 (INI1)-deficient sinonasal carcinoma: a single-institution experience. ( 26407663 )
2015
22
Role of p40 and cytokeratin 5/6 in the differential diagnosis of sinonasal undifferentiated carcinoma. ( 25017972 )
2014
23
Esthesioneuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma: differentiation in diagnosis and treatment. ( 25992139 )
2014
24
Treatment outcomes and prognostic factors including human papillomavirus (HPV) for sinonasal undifferentiated carcinoma: A retrospective review. ( 24421248 )
2014
25
Molecular profiling of sinonasal undifferentiated carcinoma. ( 23633104 )
2014
26
Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy. ( 23462605 )
2013
27
Sinonasal undifferentiated carcinoma and esthesioneuroblastoma recurring as nonintestinal adenocarcinoma. ( 23553283 )
2013
28
Improved clinical outcomes with multi-modality therapy for sinonasal undifferentiated carcinoma of the head and neck. ( 23993024 )
2013
29
Sinonasal undifferentiated carcinoma (SNUC): the Alberta experience and literature review. ( 23663264 )
2013
30
Leptomeningeal carcinomatosis in sinonasal undifferentiated carcinoma. ( 23471826 )
2013
31
Trimodality management of sinonasal undifferentiated carcinoma and review of the literature. ( 22992621 )
2013
32
Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. ( 22476411 )
2013
33
Sinonasal undifferentiated carcinoma: morphological heterogeneity, diagnosis, management and biological markers. ( 23477516 )
2013
34
Radiotherapy for sinonasal undifferentiated carcinoma. ( 24268566 )
2013
35
Meta-analysis of treatment outcomes for sinonasal undifferentiated carcinoma. ( 22460731 )
2012
36
Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. ( 23032744 )
2012
37
Sinonasal undifferentiated carcinoma presenting as recurrent fronto-ethmoidal pyomucocele. ( 23251060 )
2012
38
Minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. ( 21041001 )
2011
39
Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). ( 21805120 )
2011
40
Pediatric sinonasal undifferentiated carcinoma: case report and literature review. ( 21059557 )
2010
41
Prognostic factors for patients with sinonasal undifferentiated carcinoma. ( 21225771 )
2010
42
Primary ocular presentation of sinonasal undifferentiated carcinoma. ( 20090496 )
2010
43
Sinonasal undifferentiated carcinoma: a 13-year experience at a single institution. ( 20808529 )
2010
44
Sinonasal undifferentiated carcinoma metastatic to the skin. ( 19682175 )
2010
45
Clinical manifestations of sinonasal undifferentiated carcinoma. ( 20013673 )
2009
46
Sinonasal undifferentiated carcinoma, or schneiderian carcinoma arising from an aspergillosis: a case history. ( 19211176 )
2009
47
Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression. ( 19283847 )
2009
48
Diagnosis and treatment of sinonasal undifferentiated carcinoma: report of a case and review of the literature. ( 18571040 )
2008
49
Patterns of failure after combined-modality approaches incorporating radiotherapy for sinonasal undifferentiated carcinoma of the head and neck. ( 18207030 )
2008
50
The cytologic features of sinonasal undifferentiated carcinoma and olfactory neuroblastoma. ( 18285258 )
2008

Variations for Sinonasal Undifferentiated Carcinoma

Expression for Sinonasal Undifferentiated Carcinoma

Search GEO for disease gene expression data for Sinonasal Undifferentiated Carcinoma.

Pathways for Sinonasal Undifferentiated Carcinoma

Pathways related to Sinonasal Undifferentiated Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 MKI67 SYP

GO Terms for Sinonasal Undifferentiated Carcinoma

Sources for Sinonasal Undifferentiated Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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