MCID: SNS014
MIFTS: 54

Sinusitis malady

Summaries for Sinusitis

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Sinusitis means your sinuses are inflamed. the cause can be an infection or another problem. your sinuses are hollow air spaces within the bones surrounding the nose. they produce mucus, which drains into the nose. if your nose is swollen, this can block the sinuses and cause pain. there are several types of sinusitis, including acute, which lasts up to 4 weeks subacute, which lasts 4 to 12 weeks chronic, which lasts more than 12 weeks and can continue for months or even years recurrent, with several attacks within a year acute sinusitis often starts as a cold, which then turns into a bacterial infection. allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. there may also be mucus drainage in the back of the throat, called postnasal drip. your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. you may also need imaging tests. treatments include antibiotics, decongestants, and pain relievers. using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help. nih: national institute of allergy and infectious diseases

MalaCards: Sinusitis is related to chronic maxillary sinusitis and asthma. An important gene associated with Sinusitis is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are Rho Family GTPases and Allograft rejection. The drugs ciprofloxacin and guaifenesin and the compounds arginine and methacholine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and spinal cord.

Wikipedia:64 Sinusitis or rhinosinusitis is inflammation of the paranasal sinuses. It can be due to infection,... more...

Aliases & Classifications for Sinusitis

Sources:
10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS
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Aliases & Descriptions:

sinusitis 10 45 34 61


Related Diseases for Sinusitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Sinusitis family:

chronic frontal sinusitis acute frontal sinusitis
frontal sinusitis

Diseases related to Sinusitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 423)
idRelated DiseaseScoreTop Affiliating Genes
1chronic maxillary sinusitis31.2IGLV9-49
2asthma30.6CCL11, PRG2, IGHE, MUC5B, RNASE3, IL5
3allergic bronchopulmonary aspergillosis30.5IL5, IGHE
4cystic fibrosis30.5MUC5B, RNASE3, IL8, LACTB
5allergic rhinitis30.3CCL11, PRG2, IGHE, RNASE3, IL5, IL8
6common cold30.3IL8, RNASE3, CCL11
7bronchiectasis30.2IGHE, RNASE3, IL8
8bronchitis30.2RNASE3, MUC5B
9atopy30.0CCL11, PRG2, IGHE, RNASE3, IL5
10allergic asthma30.0CCL11, IGHE, RNASE3, IL5, IL8
11sagittal sinus thrombosis30.0F5, SERPINC1
12vasculitis30.0PRG2
13urticaria29.6PRG2, IGHE, RNASE3
14angioedema29.6IGHE, RNASE3, IL5
15sepsis29.6F5, IL8, LACTB, SERPINC1
16intrinsic asthma29.6IGHE, RNASE3, IL5
17sick sinus syndrome29.6SCN5A, HCN4
18uveitis29.6CCL11
19mastocytosis29.6IL5, IGHE
20acute maxillary sinusitis10.9
21sphenoid sinusitis10.8
22acute frontal sinusitis10.7
23chronic frontal sinusitis10.6
24cellulitis10.5
25orbital cellulitis10.5
26aspergillosis10.4
27cavernous sinus thrombosis10.4
28subdural empyema10.4
29ossifying fibroma10.4
30headache10.4
31chronic rhinitis10.3
32epidural abscess10.3
33sinus cancer10.3
34tonsillitis10.3
35intracranial abscess10.2
36n syndrome10.2
37blindness10.2
38paranasal sinus lymphoma10.2
39yellow nail syndrome10.2
40chronic sphenoidal sinusitis10.2
41microcornea, glaucoma, and absent frontal sinuses10.2
42rokitansky-aschoff sinuses of the gallbladder10.2
43primary ciliary dyskinesia10.2
44phaeohyphomycosis10.2
45fibrous dysplasia10.2
46adenocarcinoma10.2
47thrombophlebitis10.2
48kartagener syndrome10.2
49myospherulosis10.2
50acute sphenoidal sinusitis10.1

Graphical network of the top 20 diseases related to Sinusitis:



Diseases related to sinusitis

Clinical Features for Sinusitis

Drugs & Therapeutics for Sinusitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Sinusitis

Anatomical Context for Sinusitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Sinusitis:

33
Bone marrow, Brain, Spinal cord, Small intestine, Colon, Lung, Thyroid, Skin, Prostate, Tonsil, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Pituitary

Animal Models for Sinusitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Sinusitis

Sources:
51PubMed
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Articles related to Sinusitis:

(show top 50)    (show all 1260)
idTitleAuthorsYear
1
Survival outcomes in acute invasive fungal sinusitis: a systematic review and quantitative synthesis of published evidence. (23300010)
2013
2
Five 'nontraditional' techniques for use in patients with recalcitrant sinusitis. (23262744)
2013
3
A case of Schizophyllum commune sinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia. (23686329)
2013
4
Immunotherapy in allergic fungal sinusitis: The controversy continues. A recent review of literature. (23772324)
2013
5
Neuro-ophthalmology of invasive fungal sinusitis: 14 consecutive patients and a review of the literature. (23279383)
2013
6
Acute bacterial sinusitis in children. (24085791)
2013
7
Efficacy of NVC-422 against Staphylococcus aureus biofilms in a sheep biofilm model of sinusitis. (22434724)
2012
8
Isolated sinonasal posttransplantation lymphoproliferative disorder: a clinical and radiographic invasive fungal sinusitis look-a-like. (23392283)
2012
9
Treatment of mild to moderate sinusitis. (22450938)
2012
10
National trends in visit rates and antibiotic prescribing for adults with acute sinusitis. (23007315)
2012
11
Intensive Care Unit nosocomial sinusitis at the Rasoul Akram Hospital: Tehran, Iran, 2007-2008. (23066490)
2012
12
The relationship of rhinitis and asthma, sinusitis, food allergy, and eczema. (21737039)
2011
13
Pseudallescheria boydii species complex fungal rhinitis and sinusitis in a dog. (21852515)
2011
14
A comparative study between endoscopic middle meatal antrostomy and caldwell-luc surgery in the treatment of chronic maxillary sinusitis. (22754797)
2011
15
Microbiology of sinusitis. (21364226)
2011
16
Reversible loss of neuronal marker protein expression in a transgenic mouse model for sinusitis-associated olfactory dysfunction. (20537285)
2010
17
Immunologic factors in patients with chronic polypoid sinusitis. (20845638)
2010
18
A Rare Presentation of Occult Sinusitis: Upper Eyelid Fistula. (20337284)
2010
19
Chronic sinusitis in Malta--correlation between symptoms and CT scan. (20502738)
2010
20
The role of ultrasonography in the evaluation of maxillary sinusitis in pediatrics. (21165447)
2010
21
Endoscopic frontal sinus septectomy in the treatment of unilateral frontal sinusitis: revisiting an open technique. (19958729)
2009
22
An acute ischemic stroke secondary to sphenoid sinusitis. (19924653)
2009
23
Invasive Aspergillus flavus sinusitis: case report in a patient with biphenotypic acute leukemia. (19229393)
2009
24
Prevalence of allergic fungal sinusitis among patients with nasal polyps. (19448370)
2009
25
Antibiotics for acute maxillary sinusitis. (18425861)
2008
26
Optimizing the management of the main acute infections in pediatric ORL: tonsillitis, sinusitis, otitis media. (19082359)
2008
27
The clinical behavior of isolated sphenoid sinusitis. (17418260)
2007
28
Recurrent and prolonged frontal sinusitis. (14961854)
2004
29
Microbiology of chronic ethmoid sinusitis: is this a bacterial disease? (15547805)
2004
30
Endoscopic modified Lothrop procedure for the treatment of chronic frontal sinusitis: a systematic review. (14574300)
2003
31
Bacteriology of chronic maxillary sinusitis in relation to sinoscopic appearance. (12422968)
2002
32
Sphenoid sinusitis caused by Clostridium perfringens. (11458224)
2001
33
Basilar artery vasculitis secondary to sphenoid sinusitis--case report. (11593974)
2001
34
Association of bronchopneumonia with sinusitis due to Bordetella bronchiseptica in an experimental rabbit model. (10793917)
2000
35
IL-12 receptor beta2 and CD30 expression in paranasal sinus mucosa of patients with chronic sinusitis. (10414397)
1999
36
Isolated sphenoid sinusitis. (9403945)
1997
37
Cerebral venous thrombosis associated with maxillary and ethmoid sinusitis--a case report. (8750066)
1995
38
Three vs 10 days of trimethoprim/sulfamethoxazole for acute maxillary sinusitis. (7563550)
1995
39
Antimicrobial treatment of sinusitis. (1771306)
1991
40
Neutrophil elastase and its complex with alpha 1-antitrypsin in soluble and insoluble fractions of nasal secretions of chronic sinusitis. (1759584)
1991
41
Subacute thyroiditis as consequence of chronic bacterial sinusitis. (1676799)
1991
42
Serological evidence of viral or Mycoplasma pneumoniae infection in acute maxillary sinusitis. (2498094)
1989
43
Treatment of acute maxillary sinusitis. Erythromycin base and phenoxymethyl-penicillin (penicillin V). (6441236)
1984
44
Acute sphenoid sinusitis in children. (7102961)
1982
45
Rhinitis, sinusitis and otitis media in Kartagener's syndrome (primary ciliary dyskinesia). (6984375)
1982
46
Ostium resistance in acute maxillary and frontal sinusitis. (432475)
1979
47
Bronchiectasis; dextrocardia sinusitis; a contribution to the aetiology of bronchiectasis. (14349732)
1954
48
Treatment of osteomyelitis of the skull resulting from ethmoid and frontal sinusitis. (12995394)
1952
49
Acute suppurative frontal sinusitis; discussion. (15426159)
1950
50
Solitary myeloma mistaken for frontal sinusitis. (18111366)
1948

Genetic Variations for Sinusitis

Expression for genes affiliated with Sinusitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Sinusitis

Search GEO for disease gene expression data for Sinusitis.

Pathways for genes affiliated with Sinusitis

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome
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Compounds for genes affiliated with Sinusitis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Sinusitis according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1arginine4511.8IGHE, F5, MYH6, RNASE3, IL5, SERPINC1
2methacholine45 1112.6IGHE, CCL11, RNASE3, IL5, IL8, PRG2
3vegf4511.6CCL11, F5, IL5, IGHE, RNASE3, IL8
4histamine45 29 2413.6PRG2, IL8, RNASE3, IL5, IGHE, CCL11
5cetirizine45 29 11 2414.5IL5, RNASE3, IGHE, CCL11, IL8
6montelukast45 50 29 1114.5IL8, IL5, RNASE3, IGHE, CCL11
7budesonide45 50 1113.5IL8, IL5, RNASE3, IGHE, CCL11
8salbutamol45 50 29 11 2415.5IL8, IL5, RNASE3, IGHE, CCL11
9fluticasone propionate45 50 60 1114.5CCL11, IGHE, RNASE3, IL5, IL8
10pgd24511.5IGHE, IL5, PRG2, CCL11, RNASE3
11allergens4511.5PRG2, CCL11, IGHE, RNASE3, IL5
12pge24511.5CCL11, IL8, IL5, DPEP1, SERPINC1, RNASE3
13fmlp4511.4RNASE3, CCL11, PRG2, IL5, IL8
14unicap4511.4IGHE, IL5, RNASE3, CCL11
15sodium cromoglycate4511.4CCL11, IGHE, RNASE3, IL5
16nedocromil sodium4511.4IL8, IGHE, IL5, RNASE3
17heparin45 29 11 2414.4RNASE3, CCL11, PRG2, IL8
18salmeterol45 50 29 1114.4RNASE3, IL8, CCL11, IL5
19ketotifen45 1112.4CCL11, IGHE, RNASE3, IL5
20penicillin4511.4IGHE, IL5, LACTB, F5
21clarithromycin45 1112.4LACTB, IL5, IL8, CCL11
22ltc44511.3RNASE3, PRG2, CCL11, IL5
23lidocaine45 29 1113.3IL5, IGHE, SCN5A, SERPINC1
24tarc4511.3CCL11, IL5, IL8, IGHE
25n-formylmethionyl-leucylphenylalanine4511.3CCL11, IL8, IL5, RNASE3
26retinoic acid45 2412.3IL5, RNASE3, MYH6, IGHE, CCL11, F5
27n acetylcysteine4511.3CCL11, IGHE, IL8, RNASE3, SERPINC1
28imipenem4511.2SERPINC1, LACTB, DPEP1
29beclomethasone dipropionate4511.2RNASE3, IGHE, IL5
30indomethacin45 60 29 1114.2PRG2, IL5, IGHE, CCL11, DPEP1
31anti-histamine4511.2CCL11, RNASE3, IGHE
32lte44511.2IL5, CCL11, RNASE3
33aprotinin45 1112.2F5, IL8, IGHE, SERPINC1
34toluene diisocyanate4511.2IGHE, RNASE3, IL5
35endotoxin4511.2F5, DPEP1, RNASE3
36roxithromycin45 29 1113.2IL5, CCL11, IL8
37loratadine45 11 2413.2RNASE3, IGHE, IL8
38gabexate mesilate4511.1SERPINC1, IL8, F5
39ceftriaxone45 1112.1LACTB, F5, IL5
40pranlukast45 29 1113.1IL5, RNASE3, CCL11
41leukotriene b445 60 2413.1RNASE3, IL5, IL8, CCL11
42praziquantel45 1112.1IGHE, RNASE3, IL5
43protamine4511.1SERPINC1, F5
44sulfamethoxazole45 50 1113.1IGHE, IL5, LACTB
45prednisolone45 29 1113.1IGHE, RNASE3, CCL11, IL5
46azelastine45 1112.0IL5, IGHE, RNASE3
47hydrocortisone45 2 60 1114.0IGHE, IL8, F5, IL5
48inogatran4510.7F5, SERPINC1
49piperacillin45 1111.6LACTB, RNASE3
50hirudin4510.5F5, IL8, SERPINC1

GO Terms for genes affiliated with Sinusitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.2SERPINC1, CCL11, F5, PRG2, IGHE, MUC5B
2extracellular spaceGO:00561511.2F5, DPEP1, IL5, IL8, SERPINC1, CCL11

Biological processes related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:00693610.8HCN4, MYH6, GALR2
2immune responseGO:00695510.8IL8, IL5, IGHE, PRG2, CCL11

Products for genes affiliated with Sinusitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sinusitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet