Aliases & Classifications for Sinusitis

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Sinusitis, Aliases & Descriptions:

Name: Sinusitis 30 11 43 32 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Summaries for Sinusitis

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MedlinePlus:32 Sinusitis means your sinuses are inflamed. the cause can be an infection or another problem. your sinuses are hollow air spaces within the bones surrounding the nose. they produce mucus, which drains into the nose. if your nose is swollen, this can block the sinuses and cause pain. there are several types of sinusitis, including acute, which lasts up to 4 weeks subacute, which lasts 4 to 12 weeks chronic, which lasts more than 12 weeks and can continue for months or even years recurrent, with several attacks within a year acute sinusitis often starts as a cold, which then turns into a bacterial infection. allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. there may also be mucus drainage in the back of the throat, called postnasal drip. your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. you may also need imaging tests. treatments include antibiotics, decongestants, and pain relievers. using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help. nih: national institute of allergy and infectious diseases

MalaCards based summary: Sinusitis is related to tonsillitis and bronchitis. An important gene associated with Sinusitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are TSLP Signaling Pathway and Inflammatory Response Pathway. The drugs pseudoephedrine and pseudoephedrine hydrochloride and the compounds unicap and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:63 Sinusitis, also known as rhinosinusitis, is inflammation of the paranasal sinuses. It can be due to... more...

Related Diseases for Sinusitis

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Diseases in the Sinusitis family:

Chronic Frontal Sinusitis Acute Frontal Sinusitis
Frontal Sinusitis

Diseases related to Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 482)
idRelated DiseaseScoreTop Affiliating Genes
1tonsillitis31.2LACTB
2bronchitis31.0RNASE3
3meningitis30.9LACTB, IL8
4otitis media30.8CCL11, RNASE3, LACTB
5allergic rhinitis30.7RNASE3, IL4, IL5
6conjunctivitis30.7RNASE3
7allergic bronchopulmonary aspergillosis30.7IL4, CFTR, IL5
8common cold30.6RNASE3, IL8, CCL11
9prostatitis30.6LACTB
10rhinitis30.6RNASE3, CCL11, IL8, IL5, IL4
11bronchiectasis30.4RNASE3, IL8, CFTR
12bacterial meningitis30.4LACTB, IL8
13influenza30.2CFTR, CCL11, LACTB
14esophagitis30.1CCL11, IL5
15intrinsic asthma30.0IL4, IL5, RNASE3
16eosinophilia29.9IL8, IL5, IL4, CCL11, RNASE3
17urticaria29.9RNASE3, LTC4S
18angioedema29.8LTC4S, IL5, RNASE3
19tuberculosis29.8IL4, LACTB, CYP2B6, DEFB4A
20food allergy29.7CCL11, IL4, IL5, RNASE3
21atopy29.7CCL11, RNASE3, IL5, IL4, LTC4S
22melanoma29.7CFTR, IL4, CCL11, IL8, LACTB
23cystic fibrosis29.6RNASE3, LACTB, CFTR, IL8, DEFB4A, PI3
24uveitis29.6CCL11, IL4
25asthma29.6DEFB4A, IL4, RNASE3, CCL11, IL5, IL8
26leukemia29.3LTC4S, CFTR, CYP2B6, IL4, RNASE3, CCL11
27pneumonia29.2LACTB, DEFB4A, PI3, CFTR, CCL11, IL5
28frontal sinusitis11.0
29chronic maxillary sinusitis10.9
30acute maxillary sinusitis10.8
31sphenoid sinusitis10.8
32acute frontal sinusitis10.7
33chronic frontal sinusitis10.6
34inverted papilloma10.6
35papilloma10.6
36ethmoid sinusitis10.6
37gastroenteritis10.5LACTB
38cellulitis10.5
39paragonimiasis10.5IL5
40endophthalmitis10.5LACTB
41orbital cellulitis10.5
42strongyloidiasis10.5IL5
43aspergillosis10.5
44acute sphenoidal sinusitis10.4
45cavernous sinus thrombosis10.4
46keratoconjunctivitis sicca10.4CFTR
47subdural empyema10.4
48osteomyelitis10.4
49fibroma10.4
50kimura disease10.4IL5, RNASE3

Graphical network of the top 20 diseases related to Sinusitis:



Diseases related to sinusitis

Symptoms for Sinusitis

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Drugs & Therapeutics for Sinusitis

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Genetic Tests for Sinusitis

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Anatomical Context for Sinusitis

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MalaCards organs/tissues related to Sinusitis:

31
Bone, Testes, Brain, T cells, Tonsil, Myeloid, Bone marrow, Prostate, B cells, Lymph node, Spleen, Smooth muscle, Testis, Neutrophil, Lung, Pituitary, Breast, Colon, Thyroid, Skin, Endothelial, Eye, Spinal cord, Salivary gland, Monocytes

Animal Models for Sinusitis or affiliated genes

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MGI Mouse Phenotypes related to Sinusitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2LTC4S, IL5, IL4, CCL11, CFTR
2MP:00053878.1CCL11, IL4, IL5, IL8, LTC4S, CFTR

Publications for Sinusitis

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Articles related to Sinusitis:

(show top 50)    (show all 1573)
idTitleAuthorsYear
1
Reconstructed bone chip detachment is a risk factor for sinusitis after transsphenoidal surgery. (24375023)
2014
2
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
3
Intranasal steroids for acute sinusitis. (24293353)
2013
4
Acute sphenoid sinusitis leading to contralateral cavernous sinus thrombosis: a case report. (23883649)
2013
5
Quadrupedal head position enhances recovery from chronic maxillary sinusitis. (23731852)
2013
6
Acute sinusitis in adults--reply. (23712408)
2013
7
Comparison of clinical data, CT, and bone histopathology in unilateral chronic maxillary sinusitis. (23112270)
2013
8
Cryptococcal meningitis presenting as sinusitis in a renal transplant recipient. (24034280)
2013
9
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. (22118926)
2012
10
Inverted papilloma with associated carcinoma of the nasal cavity and paranasal sinuses: treatment outcomes. (22035165)
2012
11
Miller Fisher variant of Guillain-BarrAc syndrome masquerading as acute sphenoid sinusitis with orbital apex syndrome. (22447677)
2012
12
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
13
Sinus augmentation surgery after endoscopic sinus surgery for the treatment of chronic maxillary sinusitis: a case report. (21869684)
2011
14
Pott's puffy tumor, intracranial, and orbital complications as the initial presentation of sinusitis in healthy adolescents, a case series. (21380513)
2011
15
Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. (22461817)
2011
16
Microbiology of acute complicated bacterial sinusitis at the University of the Witwatersrand. (20822623)
2010
17
Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. (21154389)
2010
18
Subcutaneous emphysema in a case of infective sinusitis: a case report. (20678214)
2010
19
Incidence and presentation of fungal sinusitis in patient diagnosed with chronic rhinosinusitis. (22319697)
2010
20
Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis. (19910027)
2009
21
Endoscopic frontal sinus septectomy in the treatment of unilateral frontal sinusitis: revisiting an open technique. (19958729)
2009
22
Balloon sinuplasty in acute frontal sinusitis. (19936361)
2009
23
Subdural empyema complicating sinusitis. (18155385)
2008
24
Initial surgical treatment for chronic frontal sinusitis: a pilot study. (17491529)
2007
25
Frequency of recovery of pathogens causing acute maxillary sinusitis in adults before and after introduction of vaccination of children with the 7-valent pneumococcal vaccine. (16772423)
2006
26
The role of bacterial interference in otitis, sinusitis and tonsillitis. (16025067)
2005
27
Analysis of the sinusitis nasal lavage fluid proteome using capillary liquid chromatography interfaced to electrospray ionization-quadrupole time of flight- tandem mass spectrometry. (15174061)
2004
28
First case of Arthrographis kalrae ethmoid sinusitis and ophthalmitis in the People's Republic of China. (15472353)
2004
29
Management of acute maxillary sinusitis in Finnish primary care. Results from the nationwide MIKSTRA study. (15255494)
2004
30
Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis. (11577554)
2002
31
Intracranial complications of frontal sinusitis in children: Pott's puffy tumor revisited. (11549918)
2001
32
Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. (11561799)
2001
33
Experimental myospherulosis of the paranasal sinuses: a histologic rabbit study. (10793918)
2000
34
Lactoferrin and eosinophilic cationic protein in nasal secretions of patients with experimental rhinovirus colds, natural colds, and presumed acute community-acquired bacterial sinusitis. (10921988)
2000
35
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
36
Sinusitis in the common cold. (9768580)
1998
37
IL-4 and IL-13 expression in chronic sinusitis: relationship with cellular infiltrate and effect of topical corticosteroid treatment. (9176799)
1997
38
Primary-care-based randomised placebo-controlled trial of antibiotic treatment in acute maxillary sinusitis. (9078199)
1997
39
Antimicrobial treatment of sinusitis. (1771306)
1991
40
Bacteriology of chronic maxillary sinusitis in adults. (2729825)
1989
41
Serological evidence of viral or Mycoplasma pneumoniae infection in acute maxillary sinusitis. (2498094)
1989
42
Sphenoid sinusitis presenting as chronic meningitis. (3699068)
1986
43
Effects of phenylpropanolamine on ostial and nasal patency in patients treated for chronic maxillary sinusitis. (3727982)
1986
44
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
45
Conservative therapy for right frontal sinusitis in a Brahman bull. (6917610)
1982
46
Spontaneous enophthalmos associated with chronic maxillary sinusitis. (7301315)
1981
47
Nursing care study--acute frontal sinusitis with associated osteitis. (281656)
1978
48
Primary dextrocardia with situs inversus, associated with sinusitis and bronchitis in a dog. (4857725)
1974
49
Bacteriological findings in acute maxillary sinusitis. (4405604)
1972
50
OEdema of Conjunctiva from Acute Frontal Sinusitis. (19975137)
1911

Variations for Sinusitis

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Expression for genes affiliated with Sinusitis

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LifeMap Discovery
Genes differentially expressed in tissues of Sinusitis patients vs. healthy controls: 30 (show all 16)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1MMP1matrix metallopeptidase 1 (interstitial collagenase)Head Mesenchyme+5.250.000
2INHBAinhibin, beta AHead Mesenchyme+4.130.000
3KRT17keratin 17Head Mesenchyme+3.940.000
4SEC14L3SEC14-like 3 (S. cerevisiae)Nose-3.720.000
5SCGB1A1secretoglobin, family 1A, member 1 (uteroglobin)Nose-3.610.000
6GREM2gremlin 2, DAN family BMP antagonistNose-3.600.002
7FLJ26850FLJ26850 proteinNose-3.490.000
8PTHLHparathyroid hormone-like hormoneHead Mesenchyme+3.360.000
9CTHRC1collagen triple helix repeat containing 1Head Mesenchyme+3.320.000
10STK33serine/threonine kinase 33Nose-3.280.008
11WDR72WD repeat domain 72Head Mesenchyme+3.230.000
12CXorf57chromosome X open reading frame 57Nose-3.160.002
13MMP10matrix metallopeptidase 10 (stromelysin 2)Head Mesenchyme+3.140.001
14LRP1Blow density lipoprotein receptor-related protein 1BNose-3.060.003
15GBP1guanylate binding protein 1, interferon-inducibleHead Mesenchyme+3.060.000
16CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Nose-3.040.001

Search GEO for disease gene expression data for Sinusitis.

Pathways for genes affiliated with Sinusitis

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Pathways related to Sinusitis according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL8, CCL11
29.8IL4, IL5
39.8IL5, IL4
49.8IL4, IL5
59.8IL5, IL4
6
Show member pathways
9.6IL8, CFTR
79.4IL5, IL4, CCL11
8
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.4IL8, IL5, IL4
99.4IL8, IL5, IL4
109.4IL8, IL5, IL4
11
Show member pathways
9.3IL8, CCL11, CFTR
12
Show member pathways
9.2RNASE3, CCL11, IL4, IL5
13
Show member pathways
9.1CCL11, IL4, IL5, IL8
14
Show member pathways
9.1CCL11, IL4, IL5, IL8
15
Show member pathways
9.1CCL11, IL4, IL5, IL8
16
Show member pathways
9.1IL8, IL5, IL4, CCL11
17
Show member pathways
8.5CCL11, IL4, IL5, IL8, LTC4S
18
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.1IL8, IL4, CCL11, CFTR, DEFB4A

Compounds for genes affiliated with Sinusitis

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Compounds related to Sinusitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1unicap4310.0RNASE3, IL5, CCL11
2sodium cromoglycate439.9RNASE3, CCL11, IL5
3levocetirizine439.8CCL11, IL8, IL4
4epinastine43 1210.7CYP2B6, IL5, IL4
5ketotifen43 1210.7IL5, CCL11, RNASE3
6formoterol43 28 1211.7IL4, IL8, RNASE3
7praziquantel43 1210.6RNASE3, IL5, IL4
8cetirizine43 28 24 1212.6IL8, IL5, RNASE3, CCL11
9salbutamol43 49 28 24 1213.6CCL11, RNASE3, IL8, IL5
10pranlukast43 28 1211.6IL4, IL5, CCL11, RNASE3
11roxithromycin43 28 1211.6IL8, CYP2B6, CCL11, IL5
12azelastine43 1210.5RNASE3, CYP2B6, IL5, IL4
13nedocromil sodium439.5IL5, IL4, RNASE3, IL8
14n-formylmethionyl-leucylphenylalanine439.5CCL11, IL8, RNASE3, IL5
15itraconazole43 1210.5IL5, IL4, CYP2B6
16lte4439.5CCL11, RNASE3, IL5, LTC4S
17allergens439.5RNASE3, IL5, CCL11, IL4
18ltc4439.4LTC4S, RNASE3, CCL11, IL5
19rolipram43 59 2811.4IL8, IL5, IL4, CCL11
20poly(i-c)439.4IL4, IL5, IL8, CCL11
21pgd2439.4RNASE3, LTC4S, CCL11, IL5
22tarc439.4IL8, IL5, IL4, CCL11
23ltd4439.4RNASE3, IL5, LTC4S
24clarithromycin43 1210.4LACTB, IL8, IL5, CCL11
25azithromycin43 1210.3LACTB, CFTR, IL8
26erythromycin43 2 49 1212.2CYP2B6, LACTB, IL8, IL5
27salmeterol43 49 28 1212.2RNASE3, CCL11, IL4, IL5, IL8
28budesonide43 49 1211.2RNASE3, IL5, IL4, CCL11, IL8
29fluticasone propionate43 49 59 1212.2IL4, RNASE3, CCL11, IL5, IL8
30methacholine43 49 1211.2CCL11, RNASE3, IL8, IL4, IL5
31il-12439.1IL8, IL5, IL4
32anti-fungal439.1RNASE3, CYP2B6, DEFB4A, IL5
33herbimycin a43 5910.1IL5, IL8, CCL11, IL4
34n acetylcysteine438.9CFTR, IL4, RNASE3, IL8, CCL11
35indomethacin43 28 59 1211.9CCL11, CFTR, IL4, IL5, CYP2B6
36hbd2438.9IL8, DEFB4A, PI3
37aspirin43 49 28 2411.8LTC4S, IL4, CCL11, RNASE3, CFTR
38leukotriene b443 59 2410.8CYP2B6, RNASE3, CCL11, IL5, IL8, LTC4S
39montelukast43 49 28 1211.7IL5, RNASE3, CCL11, IL4, LTC4S, IL8
40ly294002438.6IL8, PI3, CCL11, IL4, IL5
41rantes438.4DEFB4A, RNASE3, IL5, IL4, CCL11, IL8
42pge2438.2CFTR, IL4, RNASE3, CCL11, LTC4S, IL5
43genistein43 28 59 2 24 1213.1CFTR, DEFB4A, CCL11, IL5, IL8
44sb 20358043 599.0DEFB4A, IL4, PI3, IL8, CCL11, IL5
45cyclosporin a43 28 599.8IL4, IL5, IL8, CCL11, RNASE3, CFTR
46retinoic acid43 248.7RNASE3, CCL11, CYP2B6, CFTR, PI3, DEFB4A
47cysteine437.3LTC4S, IL8, IL5, DEFB4A, IL4, CFTR
48histamine43 28 249.3RNASE3, IL8, LTC4S, IL5, IL4, CCL11
49tyrosine437.2LTC4S, DEFB4A, PI3, CYP2B6, RNASE3, CCL11
50dexamethasone43 49 28 129.5CYP2B6, IL5, LTC4S, IL8, PI3, IL4

GO Terms for genes affiliated with Sinusitis

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Cellular components related to Sinusitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056159.1IL8, IL5, IL4, CCL11
2extracellular regionGO:00055768.1IL8, IL5, CCL11, RNASE3, DEFB4A

Biological processes related to Sinusitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:00308909.7IL5, IL4
2response to cytokineGO:00340979.6IL4, CFTR
3inflammatory responseGO:00069549.2IL8, IL5, CCL11
4chemotaxisGO:00069358.6DEFB4A, CCL11, IL4, IL8
5immune responseGO:00069558.3IL8, IL5, IL4, CCL11, DEFB4A

Molecular functions related to Sinusitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.8IL8, CCL11

Products for genes affiliated with Sinusitis

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Sources for Sinusitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet