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Sinusitis malady
29 drugs, 272 genes, 21 tissues, 1091 related diseases, 28 phenotypes, 426 articles, clinical trials.

Summaries for Sinusitis

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23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Sinusitis means your sinuses are infected or inflamed. your sinuses are hollow air spaces within the bones surrounding the nose. they produce mucus, which drains into the nose. if your nose is swollen, this can block the sinuses and cause pain and infection. sinusitis can be acute, lasting for less than four weeks, or chronic, lasting much longer. acute sinusitis often starts as a cold, which then turns into a bacterial infection. allergies, pollutants, nasal problems and certain diseases can also cause sinusitis. symptoms of sinusitis can include fever, weakness, fatigue, cough and congestion. there may also be mucus drainage in the back of the throat, called postnasal drip. treatments include antibiotics, decongestants and pain relievers. using heat pads on the inflamed area, saline nasal sprays and vaporizers can also help. nih: national institute of allergy and infectious diseases23

MalaCards: Sinusitis is related to ethmoid sinusitis and chronic sphenoidal sinusitis. An important gene associated with Sinusitis is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are Jak-STAT signaling pathway and Bacterial infections in CF airways. The drugs cefuroxime and ciprofloxacin and the compounds valine and thapsigargin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are cardiovascular system and embryogenesis.

Wikipedia: Sinusitis is inflammation of the paranasal sinuses, which may be due to infection, allergy, or...44 more...

Aliases & Descriptions for Sinusitis

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8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS
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sinusitis 8 32 23 43

Related Diseases for Sinusitis

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13GeneCards, 14GeneDecks
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Diseases related to sinusitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1088)
idRelated DiseaseScoreTop Affiliating Genes
1ethmoid sinusitis34.2PIK3CA, PI3, MUC4, MUC7, IL1B, IL4
2chronic sphenoidal sinusitis34.1MUC2, MUC5AC, MUC8, LACTB, CFTR, IL13
3chronic maxillary sinusitis33.7LACTB, MPO, GYPA, IGLV9-49, CYS1, RNASE3
4frontal sinusitis33.2ARHGEF16, AP4M1, AKT1S1, TUBE1, DPEP1, DCXR
5sphenoid sinusitis32.9GOLPH3, GJB6, GH1, NT5C2, KLK3, ACPP
6paranasal sinus disease32.3SERPINE1, IL17A, IL5, IFNG, PLAU, PLAUR
7allergic rhinitis31.7VCAM1, IL13, IL4, IL5, IGES, IGHE
8petrositis31.4AVP, IGF1, GH1, PTHLH, CRH, OXT
9inverted papilloma31.2PCNA, SERPINB3, CDKN1A, CDKN2A, CDX2, MMP2
10asthma30.3IL13, IL4, IL5, IGES, IGHE, RNASE3
11common cold30.2SELP, MUC5B, CFTR, IL5, IL8, CCL11
12venous thrombosis28.9VWF, SELP, SERPINC1, SERPINE1, MTHFR, APOH
13allergic bronchopulmonary aspergillosis28.8SFTPD, CFTR, IL4, IL5, IGES, IGHE
14cushing's syndrome28.4BGLAP, INS, IGF1, CALCA, GH1, NR3C1
15diffuse panbronchiolitis28.4MUC5AC, MUC5B, MUC7, MPO, CD79A, IL13
16panbronchiolitis28.4MUC5AC, MUC5B, MUC7, MPO, CD79A, IL13
17squamous cell carcinoma28.2SERPINB3, SERPINB4, MKI67, GSTP1, CCND1, TP73
18eosinophilia28.1SFTPD, SELL, VCAM1, MUC1, MPO, CD79A
19polyposis28.0RELA, PCNA, SERPINE1, VIM, VEGFA, VCAM1
20rhinitis27.8RELA, SFTPD, BTK, SELL, SERPINE1, VEGFA
21aspergillosis27.8SFTPD, CFTR, CD79A, IL17A, IL1B, IL1RN
22atopic dermatitis27.7SELL, SELP, VCAM1, CD40, MIF, IL12B
23wegener's granulomatosis27.7VWF, SERPINE1, SERPINA3, VCAM1, MTHFR, MPO
24breast cancer27.4PIK3CA, MYC, BMP6, CCND1, IFI27, GJA1
25adenoid cystic carcinoma27.2PCNA, SERPINA3, VIM, MUC1, S100A1, MKI67
26immunodeficiency27.1BTK, SELL, BMP6, CLEC4M, S1PR1, CD79A
27common variable immunodeficiency26.8BTK, SELL, BGLAP, SCNN1B, SCNN1G, B2M
28cystic fibrosis26.8PI3, VWF, SFTPD, PCNA, SELL, SELP
29hydrocephalus26.5LRG1, VIM, MTHFR, ASRGL1, INS, FAS
30papilloma26.5PCNA, SERPINB3, VIM, VEGFA, BIRC5, MUC1
31haemophilus influenzae26.2MUC2, MUC5AC, LACTB, MPO, IL1B, IL2RA
32squamous cell carcinoma of the head and neck26.2PIK3CA, VEGFA, MYC, BIRC5, BCL2L1, CDKN1A
33atopy25.6RELA, SELP, VEGFA, MTHFR, CFTR, MPO
34fibrosis25.5PIK3CA, PI3, LRG1, RELA, VWF, SFTPD
35prion disease25.0PIK3CA, SELP, SERPINA3, BCL2L1, BAX, AVP
36thrombosis25.0VWF, PCNA, SELL, SELP, SERPINC1, SERPINE1
37carcinoma24.9PIK3CA, PI3, RELA, VWF, SFTPD, PCNA
38infertility24.7SERPINE1, VEGFA, BMP6, BIRC5, MUC1, MUC4
39influenza24.2PIK3CA, RELA, SFTPD, SELL, SERPINE1, CLEC4M
40dermatitis24.0PI3, RELA, SFTPD, BTK, SELL, SELP
41rhabdomyosarcoma23.8PCNA, VIM, VEGFA, MYC, MYOG, BMP6
42adenocarcinoma23.8PIK3CA, LRG1, RELA, VWF, SFTPD, PCNA
43pneumonia23.2PI3, RELA, SFTPD, BTK, SELL, SERPINC1
44cerebritis22.9RELA, VWF, PCNA, SELP, SERPINC1, SERPINE1
45melanoma22.6PIK3CA, PI3, RELA, VWF, PCNA, SELP
46prostatitis22.6PIK3CA, RELA, VWF, SFTPD, PCNA, SELP
47nephropathy21.6LRG1, RELA, VWF, PCNA, SELL, SELP
48headache21.5VCAM1, MTHFR, CD40LG, INS, IL1B, IL1RAPL2
49respiratory failure15.0SFTPD, MUC2, MUC5AC, LACTB, CFTR, IL13
50maxillary sinus squamous cell carcinoma14.8PCNA, VEGFA, BCL2L1, BAX, CDKN1A, GSTP1

Graphical network of the top 20 diseases related to sinusitis:



Graphical network of diseases related to sinusitis

Clinical Features for Sinusitis

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Drugs & Therapeutics for Sinusitis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Inferred drug relations via UMLS/NDF-RT:

43 28 alatrofloxacin, alatrofloxacin mesylate, amoxicillin, amoxicillin trihydrate, cefdinir, cefprozil, cefuroxime, cefuroxime axetil, cefuroxime sodium, ciprofloxacin, ciprofloxacin hydrochloride, clarithromycin, dexbrompheniramine, dexbrompheniramine maleate, gatifloxacin, guaifenesin, loracarbef, moxifloxacin, moxifloxacin hcl, naphazoline, naphazoline hydrochloride, penicillin v potassium, pseudoephedrine, pseudoephedrine hydrochloride, pseudoephedrine sulfate, tetrahydrozoline, tetrahydrozoline hydrochloride, trovafloxacin, trovafloxacin mesylate

Genetic Tests for Sinusitis

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Anatomical Context for Sinusitis

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22MalaCards
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MalaCards organs/tissues related to sinusitis:

22
Bone marrow, Lymph node, Spleen, Brain, Heart, Small intestine, Colon, Liver, Salivary gland, Adrenal gland, Breast, Ovary, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Cardiac myocytes, Bronchial epithelium, Pituitary

Phenotypes for genes affiliated with Sinusitis

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25MGI
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MGI Mouse Phenotypes related to sinusitis:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cardiovascular system phenotypeMP:0005385INFPIK3CA, , RELA, VWF, SELL, SELP
2embryogenesis phenotypeMP:0005380INFPIK3CA, , SERPINC1, VIM, , MYC
3behavior/neurological phenotypeMP:0005386INFPIK3CA, , SELP, VIM, MYOG, KCNQ1
4limbs/digits/tail phenotypeMP:0005371INFRELA, , VEGFA, , BMP7, BAX
5mortality/agingMP:0010768INFPIK3CA, , RELA, VWF, SFTPD,
6cellular phenotypeMP:0005384INFPIK3CA, , RELA, VWF, PCNA,
7immune system phenotypeMP:0005387INF, VWF, , SELL, SELP, VIM
8digestive/alimentary phenotypeMP:0005381INFVWF, , VEGFA, MYC, BMP7, KCNQ1
9vision/eye phenotypeMP:0005391INFPIK3CA, , RELA, SELP, SERPINC1, VIM
10normal phenotypeMP:0002873INF, RELA, VEGFA, , MYC, MYOG
11tumorigenesisMP:0002006INFPIK3CA, , , SELL, SERPINE1, MYC
12no phenotypic analysisMP:00030129.5PCNA, VEGFA, VCAM1, MYC, MUC1, MTHFR
13liver/biliary system phenotypeMP:00053709.4SERPINC1, VEGFA, CFTR, INS, IL12RB2, IL2
14skeleton phenotypeMP:00053907.6RELA, VEGFA, MYC, MYOG, BMP6, BMP7
15adipose tissue phenotypeMP:00053756.9PIK3CA, SERPINE1, MYC, MYOG, CDKN1A, INS
16other phenotypeMP:0005395INFSCNN1G, CDKN2A, CD40LG, IL13, IL2, GJA1
17hematopoietic system phenotypeMP:0005397INFPCNA, , BCL2L1, S1PR1, MPL, CDKN1A
18reproductive system phenotypeMP:0005389INFPIK3CA, VEGFA, , BMP7, B2M, CGA
19respiratory system phenotypeMP:0005388INFSFTPD, SELL, SELP, , MYOG, SCNN1B
20integument phenotypeMP:0010771INFRELA, , SELP, MYC, MYOG, BCL2L1
21growth/size phenotypeMP:0005378INFPIK3CA, , RELA, SFTPD, , SELP
22hearing/vestibular/ear phenotypeMP:0005377INF, MYC, BMP7, KCNQ1, BAX, CDKN1A
23craniofacial phenotypeMP:0005382INF, KCNH2, CFTR, FIG4, MESP1, IL12B
24endocrine/exocrine gland phenotypeMP:0005379INFSELL, CD40LG, CDX2, IL2, IL2RB, IFNG
25renal/urinary system phenotypeMP:0005367INFSELP, BMP7, SCNN1B, SCNN1G, BAX, AVP
26homeostasis/metabolism phenotypeMP:0005376INFPIK3CA, RELA, VWF, SFTPD, , SELL
27muscle phenotypeMP:0005369INFPIK3CA, RELA, VIM, VEGFA, MYC, MYOG
28nervous system phenotypeMP:0003631INF, RELA, VWF, SELP, SERPINC1,

Publications for genes affiliated with Sinusitis

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35PubMed
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Articles related to sinusitis:

(show top 50)    (show all 426)
idTitleAuthorsYearAffiliating Genes
1A floating thrombus in sinus of valsalva complicated with cardiogenic shock in a patient with plasminogen activator inhibitor 1 4G/5 G polymorphism. (21545519)Saygi S.... Tengiz I.2011SERPINE1
2Inferior petrosal sinus ACTH and prolactin responses to CRH in ACTH-dependent Cushing's syndrome: a single centre experience from th e United Kingdom. (19768550)Daousi C.... MacFarlane I.A.2010PRL, CRH
3Multiple loss-of-function mechanisms contribute to SC N5A-related familial sick sinus syndrome. (20539757)Gui J.... Lei M.2010SCN5A
4Immunologic factors in patients with chronic polypoid sinusitis. (20845638)Nikakhlagh S.... Rahim F.2010IGHE
5Effect of prothrombin 19911 A>G polymorphism on th e risk of cerebral sinus-venous thrombosis. (20482605)Martinelli I.... Mannucci P.M.2010F2, F5
6Sinusal localization of nodal micrometastases is a pr ognostic factor in breast cancer. (19875751)Masci G.... Santoro A.2010ERBB2
7Genetic variation in the inwardly rectifying K channe l subunits KCNJ3 (GIRK1) and KCNJ5 (GIRK4) in patients with sinus node dysfunct ion. (20110696)Holmegard H.N.... Svendsen J.H.2010KCNJ3, KCNJ5
8Ser49gly polymorphism as predictor of development of hereditary sick sinus node syndrome (19845516)Nikulina S.I.u.... Kazarinova I.u.L.2009ADRB1
9Upregulation of elafin and cystatin C in the ethmoid sinus mucosa of patients with chronic sinusitis. (19687396)Lee C.W.... Lee S.H.2009PI3
10Up-regulation of heparanase in the ethmoid sinus mucosa of patients with chronic sinusitis. (19401035)Kim T.H.... Lee S.H.2009HPSE
11A woman with rectal sinus and left transversal sinus thrombosis after ovarian stimulation: case report. (19022798)Santoro R.2009F2
12Allergic fungal sinusitis: pathophysiology, diagnosis and management. (19330659)Schubert M.S.2009IGHE, IGES
13Acromegaly in a patient with normal pituitary gland a nd somatotropic adenoma located in the sphenoid sinus. (18777506)Kurowska M.... Janczarek M.2008GH1
14Increased expression of glycoprotein 340 in the ethmoid sinus mucosa of patients with chronic sinusitis. (18025314)Kim T.H.... Hwang H.Y.2007DMBT1
15Ultrasound and magnetic resonance images of endoderma l sinus tumor. (18063508)Hung J.H.... Lai C.R.2007AFP
16Cerebral venous sinus thrombosis as a recurrent thrombotic event in a patient with heterozygous prothrombin G20210A genotype after discontinuation of oral anticoagulation therapy: how long should we treat these patients with warfarin? (17245631)Jukic I.... Rosenzweig D.2007F2, SERPINC1
17Pseudotumor cerebri from sinus venous thrombosis, associated with polycystic ovary syndrome and hereditary hypercoagulability. (17454173)Finsterer J.... Krugluger W.2007F2
18Total IgE levels do not change 1 year after endoscopic sinus surgery in patients with chronic rhinosinusitis. (16374024)Lal D.... Naclerio R.M.2006IGHE
19The use of radiolabelled human serum albumin and SPECT/MRI co-registration to study inflammation in the cavernous sinus of cluster headache patients. (16919062)Schuh-Hofer S.... Arnold G.2006ALB
20Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary sinus squamous cell carcinoma. (16012042)Bandoh N.... Harabuchi Y.2005CDKN1A, IFI27
21Immunohistochemical analyses of MUC5AC mucin expression in sinus mucosa of children with sinusitis and controls. (16425564)PeA+a M.T.... Rose M.C.2005MUC5AC
22Cytokine profile in paranasal effusions in patients with chronic sinusitis using the YAMIK sinus catheter with and without betamethasone. (14963719)Furukido K.... Yajin K.2005IL1B, IL8
23Allergic fungal sinusitis. A naso-sinusal specific hyperreactivity for an infectious disease? (14677309)Corradini C.... Paludetti G.2003IGHE
24Comparison of the prothrombin levels between the patients with atrial fibrillation and patients with cardiac pacemaker implantation due to sick sinus syndrome during anticoagulation therapy with warfarin (12233104)Iwahashi H.... Morita T.2002F2
25Study of allergic fungal sinusitis in 40 surgical cases of chronic paranasal sinusitis (12607281)Kawabori S.... Taniguchi M.2002IGHE
26Allergic fungal sinusitis: an immunohistologic analysis. (11112892)Khan D.A.... Leiferman K.M.2000ELANE, PRG2
27Immunohistochemical localization of cytokines and cell adhesion molecules in maxillary sinus mucosa in chronic sinusitis. (10648069)Nonoyama T.... Sakakura Y.2000IL8
28Eosinophilic apoptosis in sinus mucosa: relationship to tissue eosinophilia and its resolution in allergic sinusitis. (10984377)Fan G.K.... Takenaka H.2000FAS
29Stereotactic radiosurgery for pituitary adenoma invading the cavernous sinus. (11143249)Shin M.... Kirino T.2000POMC, GH1
30Plasma endothelin-1 and thrombomodulin levels in coronary sinus during right atrial pacing and percutaneous transluminal coronary angioplasty. (10854676)Suzuki H.... Katagiri T.2000EDN1, THBD
31Proliferation, vascular endothelial growth factor expression and cavernous sinus invasion in growth hormone secreting pituitary adenomas. (11214627)Iuchi T.... Yamaura A.2000VEGFA
32An increase in plasma atrial natriuretic peptide concentration during exercise predicts a successful cardioversion and maintenance of sinus rhythm in patients with chronic atrial fibrillation. (11139947)Wozakowska-Kaplon B.... Janion M.2000NPPA
33Cardiac endothelin release into the coronary sinus in myocardial ischemia and coronary endothelial injury (10506396)KrA1ger D.... Giannitsis E.1999EDN1
34Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus. (10890777)Wagner J.A.... Gardner P.1999AAVS1
35IL-12 receptor beta2 and CD30 expression in paranasal sinus mucosa of patients with chronic sinusitis. (10414397)Suzuki H.... Takasaka T.1999IL12RB2
36Comparison of sinusitis with and without allergic rhinitis: characteristics of paranasal sinus effusion and mucosa. (10326748)Suzuki M.... Mogi G.1999IL5
37Ion transport in nasal and paranasal sinus mucosa in mucoviscidosis and chronic sinusitis (10231698)RA1ckes-Nilges C.... Weber W.M.1999CFTR
38Coronary sinus adrenomedullin rises in response to myocardial injury. (10087250)Vijay P.... Sharp T.G.1999ADM
39Case-control study of risk of cerebral sinus thrombosis in oral contraceptive users and in [correction of who are] carriers of hereditary prothrombotic conditions. The Cerebral Venous Sinus Thrombosis Study Group. (9518910)de Bruijn S.F.... Vandenbroucke J.P.1998SERPINC1, F5
40GM-CSF, IL-5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP). (9761019)Hamilos D.L.... Hamid Q.1998CCL5, IL5
41Clinical features and characteristics of paranasal sinus effusion in allergic sinusitis (9711083)Suzuki M.... Mogi G.1998IL1B, IL8, IL5
42Expression of IgE heavy chain transcripts in the sinus mucosa of atopic and nonatopic patients with chronic sinusitis. (9569241)Ghaffar O.... Hamid Q.1998IL4, IL13, IGHE
43RANTES is more prevalent in bacterial than in nonbacterial maxillary sinusitis: and P-selectin is preferentially up-regulated in diseased mucosae. (9339988)Westergren V.... Hellquist H.B.1997SELP, IL6, CCL5
44Experimental studies and clinical significance of p53 gene mutation in carcinomas of the nasal cavity and paranasal sinuses (9812797)Yang W.... Jiang S.1997TP53
45Chronic sinusitis refractory to standard management in patients with humoral immunodeficiencies. (9328124)Buehring I.... Zielen S.1997RNASE3
46Positive identification in situ of mRNA expression of IL-6, and IL-12, and the chemotactic cytokine RANTES in patients with chronic sinusitis and polypoid disease. Clinical relevance and relation to allergy. (8831850)Davidsson A.... Hellquist H.B.1996IL6
47Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. (7677187)Kraal G.... Butcher E.C.1995MADCAM1
48Root agenesis associated with chronic infection and traumatic curettage of the maxillary sinus. (8058549)Seow W.K.1994DSPP
49Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders. (8055153)Paulli M.... Bonetti F.1994CTSD
50Cytotoxicity of human eosinophil granule major basic protein to human nasal sinus mucosa in vitro. (2370389)Hisamatsu K.... Koyama H.1990PRG2

Expression for genes affiliated with Sinusitis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Sinusitis

Pathways for genes affiliated with Sinusitis

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20KEGG, 41Thomson Reuters, 36QIAGEN, 10EMD Millipore, 37R&D Systems
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Pathways related to sinusitis according to GeneDecks:

(show top 50)    (show all 104)
idPathwayScoreTop Affiliating Genes
1Jak-STAT signaling pathway2011.0PIK3CA, MYC, BCL2L1, MPL, IL12A, IL12B
2Bacterial infections in CF airways4110.7RELA, SFTPD, MUC1, CFTR, CTSB, TLR2
3Measles2010.0PIK3CA, RELA, CLEC4M, CD46, IL12A, IL12B
4Bladder cancer209.9VEGFA, MYC, CDKN1A, CDKN2A, MMP2, MMP9
5Asthma209.9CD40LG, CD40, IL13, IL3, IL4, IL5
6Cytokine Network369.5IL12A, IL12B, IL13, IL1B, IL2, IL3
7Amoebiasis209.5PIK3CA, RELA, SERPINB3, SERPINB4, MUC2, IL12A
8Pathways in cancer209.3PIK3CA, RELA, VEGFA, MYC, BIRC5, BCL2L1
9Toll-like receptor signaling pathway209.0PIK3CA, RELA, CD40, IL12A, IL12B, IL1B
10Cytokine-cytokine receptor interaction208.5VEGFA, BMP7, MPL, CD40LG, CD40, IL12A
11Immune response MIF-mediated glucocorticoid regulation108.5RELA, VCAM1, MIF, IL2, IL6, IL8
12Immune response_MIF-mediated glucocorticoid regulation418.5RELA, VCAM1, MIF, IL2, IL6, IL8
13Immune response MIF in innate immunity response108.4RELA, MIF, IL1B, IL6, IL8, IFNG
14Malaria208.4SELP, VCAM1, CD40LG, CD40, GYPA, IL12A
15Leishmaniasis208.4RELA, IL12A, IL12B, IL1B, IL4, MAPK1
16Tuberculosis208.4RELA, CLEC4M, BAX, MRC1, IL12A, IL12B
17Immune response_MIF in innate immunity response418.2RELA, MIF, IL1B, IL6, IL8, IFNG
18Renin-Angiotensin Pathway368.1VCAM1, BMP6, BMP7, UTS2, FGF2, FGF23
19NF-KappaB (p50-p65) Pathway368.0RELA, BMP6, BMP7, UTS2, FGF2, FGF23
20Chagas disease (American trypanosomiasis)208.0PIK3CA, RELA, SERPINE1, IL12A, IL12B, IL1B
21Apoptotic Pathways in Synovial Fibroblasts368.0BMP6, BMP7, UTS2, FGF2, FGF23, IL2
22Colorectal Cancer Metastasis367.9MYC, BIRC5, BCL2L1, BAX, CDKN1A, MMP2
23NF-KappaB Family Pathway367.9RELA, BMP6, BMP7, UTS2, FGF2, FGF23
24Pancreatic Adenocarcinoma367.7BMP6, BMP7, UTS2, BIRC5, BCL2L1, CDKN1A
25SOCS Pathway36INF, BMP6, BMP7, BAX, INS, FGF2
26ERK Signaling36INF, MYC, BMP6, BMP7, UTS2, FGF23
27Tec Kinases Signaling36INF, BMP6, BMP7, UTS2, BAX, FGF2
28p38 Signaling36INF, BMP6, BMP7, UTS2, BAX, FGF2
29IL-6 Pathway36INF, BMP6, BMP7, BAX, IL12A, IL12B
30Akt Signaling36INF, BMP7, UTS2, FGF23, IL12B, IL12RB1
31PEDF Induced Signaling36INFRELA, , BMP6, BMP7, BCL2L1, BAX
32MAPK Family Pathway36INF, BMP6, BMP7, UTS2, BAX, ARHGEF16
33PGC1Alpha Pathway36INF, BMP6, BMP7, BAX, IL12A, IL12B
34Endothelin-1 Signaling Pathway36INF, MYC, BMP6, BMP7, IL12A, IL12B
35Regulation of eIF4 and p70S6K36INF, BAX, FGF23, IL12A, IL12B, IL13
36JAK-STAT Pathway36INF, MYC, BMP6, BMP7, UTS2, BAX
37Rho Family GTPases36INF, VIM, BMP6, BMP7, UTS2, BAX
38STAT3 Pathway36INF, MYC, BMP6, BMP7, BAX, CDKN1A
39RAR-Gamma-RXR-Alpha Degradation36INF, BMP7, IL12A, IL2, IL3, CCL7
40PAK Pathway36INF, BMP6, BMP7, UTS2, BAX, FGF2
41Th1 Differentiation37INFIL12A, IL12B, IL12RB1, IL12RB2, IL2, IFNG
42Glucocorticoid Receptor Signaling36INF, BMP6, BMP7, BAX, CDKN1A, IL12A
43Molecular Mechanisms of Cancer36INF, , MYC, BMP6, BMP7, UTS2
44JNK Pathway36INF, BMP6, BMP7, UTS2, BAX, FGF2
45Antioxidant Action of Vitamin-C36INF, BMP6, BMP7, UTS2, BAX, FGF2
46MIF Regulation of Innate Immune Cells36INF, BMP6, BMP7, BAX, MIF, IL12A
47MIF Mediated Glucocorticoid Regulation36INF, BMP6, BMP7, BAX, MIF, IL12A
48all-trans-Retinoic Acid Signaling in Brain36INF, BMP6, BMP7, BAX, IL12A, IL12B
49NFAT Signaling and Lymphocyte Interactions36INF, BMP6, BMP7, BAX, IL12A, IL12B
50TGF-Beta Pathway36INF, BMP6, BMP7, UTS2, BAX, FGF2

Compounds for genes affiliated with Sinusitis

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Sources:
32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
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Compounds related to sinusitis according to GeneDecks:

(show top 50)    (show all 477)
idCompoundScoreTop Affiliating Genes
1valine32 INFSERPINA3, VIM, KCNH2, SCN5A, MTHFR, B2M
2thapsigargin32 42 INFPCNA, , SERPINE1, UTS2, BCL2L1, CFTR
3cysteine32 INFPI3, SFTPD, PCNA, , SELP, SERPINB4
4allergens32 11.1SFTPD, CLEC4M, CD79A, CD40LG, CD40, IL13
5sp 60012532 42 11.9VCAM1, CDKN1A, CD40, IL13, IL17A, TP53
6sodium nitroprusside32 10.7VWF, PCNA, BMP6, KCNJ5, CGA, CD40
7aprotinin32 9 9 12.6VWF, SELP, SERPINC1, MMP2, MMP9, IGF1
8hyaluronic acid32 18 11.6VIM, MYC, BMP6, MUC1, B2M, FGF2
9budesonide32 42 9 9 13.6SFTPD, BGLAP, IL5RA, CCL11, IGHE, NR3C1
10nicotine32 34 9 9 13.6SELL, BIRC5, PTHLH, CRH, KRT1, OXT
11forskolin32 42 9 9 13.5VIM, MYOG, BMP6, KCNH2, MUC1, MUC2
12hematoxylin32 10.5PCNA, VIM, MUC1, MUC2, MUC5AC, S100A1
13mannose32 10.5SFTPD, CLEC4M, MRC1, CD79A, CD40, CD46
14epinephrine32 9 18 9 13.4SELL, SELP, BMP6, KCNQ1, CGA, CFTR
15cyclic amp32 18 11.3SFTPD, KCNH2, S1PR1, CGA, CFTR, CDKN2A
16phosphatidylcholine32 10.1SFTPD, VIM, VCAM1, MUC5AC, CD79A, FGF2
17polyethylene glycol32 10.0SERPINC1, MUC1, MPL, MPO, ALPP, ERBB2
18theophylline32 9 18 9 12.9SELL, SELP, MYC, B2M, CGA, CD79A
19p00232 9.8BIRC5, MTHFR, CD63, MMP9, MKI67, IL17A
20gnrh32 9.8SELL, SERPINE1, VIM, CGB7, CFTR, MKI67
21heparin32 9 18 9 12.8PIK3CA, VWF, SERPINE1, SERPINA3, VIM, BGLAP
22etoposide32 42 9 9 12.8PIK3CA, PCNA, MYC, BIRC5, BCL2L1, BAX
23gefitinib32 34 9 9 12.7PIK3CA, SFTPD, SELP, VIM, VEGFA, BIRC5
24fmlp32 9.7SELL, SELP, SERPINA3, VIM, VCAM1, MPO
25betacarotene32 9.6VWF, PCNA, SERPINA3, MTHFR, CD79A, IL2RA
26cyclosporin a32 42 10.6PIK3CA, PI3, VWF, SELP, MYC, BGLAP
27acth32 9.5MUC1, AVP, MIF, INS, IL1B, IL1RN
28ag 147832 9.5PIK3CA, SERPINE1, MUC5AC, MMP2, MMP9, IL8
29doxorubicin32 34 9 9 12.5PIK3CA, VIM, BMP6, BCL2L1, B2M, CGA
301,25 dihydroxy vitamin d332 9.3MYC, BMP6, BGLAP, FGF23, IL1RAPL2, IL2RB
31poly(i-c)32 9.1VCAM1, IL12B, IL1B, IL3, IL4, IL5
32lipoteichoic acid32 9.0IL12B, IL1B, IL1RN, IL6, IL8, APOH
33prostacyclin32 8.7VWF, SELP, SERPINC1, SERPINE1, VEGFA, VCAM1
34infliximab32 9 9 10.7VEGFA, BGLAP, FGF2, IL17A, IL1B, IL1RAPL2
35sulfasalazine32 9 9 10.6MTHFR, MPO, CD79A, CD40LG, IL12B, IL1B
36paclitaxel32 34 9 9 11.6PIK3CA, PCNA, VIM, VEGFA, MYC, BMP6
37prednisolone32 9 9 10.1VWF, SFTPD, SELL, VCAM1, MYC, BMP6
38tetracycline32 9 9 10.0VWF, BGLAP, LACTB, CDKN2A, CD40LG, MMP2
398-isoprostane32 7.7SERPINE1, VCAM1, MPO, MMP2, MMP9, INS
40cisplatin32 34 9 9 10.7PIK3CA, PCNA, VEGFA, MYC, BMP6, BIRC5
41il 1032 7.0BMP6, CD40, IL12B, IL13, IL1B, IL1RAPL2
42dexamethasone32 42 34 9 9 10.0PIK3CA, PI3, VWF, SFTPD, PCNA, SELL
4312-o-tetradecanoylphorbol 13-acetate32 INFMYC, MYOG, BMP6, MUC2, CDKN1A, MMP2
44ivig32 INFVWF, , IL1RAPL2, IL3, CRP, LTA
45testosterone32 9 18 9 INFPIK3CA, RELA, PCNA, SERPINC1, VIM, VCAM1
46cholesterol32 9 18 9 INFPIK3CA, , VWF, SFTPD, SELP, SERPINE1
47h2o232 INFVWF, SELL, UTS2, BGLAP, CGA, CFTR
48folate32 INFVWF, SERPINC1, SERPINA3, VIM, VCAM1, MYC
49alanine32 INFVWF, PCNA, SELL, SERPINC1, VCAM1, MYC
50retinoid32 INFSELL, VIM, MYC, BMP6, BCL2L1, MUC5AC

GO Terms for genes affiliated with Sinusitis

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Sources:
12Gene Ontology
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Cellular components related to sinusitis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:005886INFERBB2, GYPA, CD46, CD7, CD40, CD63
2secretory granuleGO:03014110.3LTF, OXT, POMC, AVP, VEGFA, MPO
3Golgi lumenGO:0057969.4PROC, MUC4, DEFB4A, DEFB1, TGFB1, F2
4platelet alpha granule lumenGO:0310939.4TGFB1, TIMP1, PF4, ALB, F5, IGF1
5external side of plasma membraneGO:0098979.0EMR1, B2M, S1PR1, SCNN1G, SCNN1B, KCNJ5
6extracellular regionGO:0055768.0PROC, CRP, CRISP3, CRH, SNCA, NTS
7extracellular spaceGO:0056157.0CSF3, CSF2, SOD1, PROC, OXT, DPEP1
8integral to plasma membraneGO:005887INFGJA1, CD99, CD40LG, CD63, CD40, CD46

Biological processes related to sinusitis according to GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693511.1FGF2, IL4, MAPK1, CCL7, PLAUR, DEFB4A
2immune responseGO:00695511.0HLA-DQB1, IGHE, CCL13, CCBP2, CCL11, CCL7
3defense response to bacteriumGO:04274210.9IFNG, TLR9, CAMP, DEFB1, DEFB4A, STAB2
4positive regulation of angiogenesisGO:04576610.6FGF2, SERPINE1, VEGFA, UTS2, MMP9, IL1B
5positive regulation of B cell proliferationGO:03089010.6IL4, TLR4, PTPRC, IL2, IL5, IL13
6elevation of cytosolic calcium ion concentrationGO:00720410.2CYSLTR1, CALCA, CAV3, KNG1, IL1B, IL2
7cell-cell signalingGO:00726710.2IL2, EDN1, PTHLH, GJA5, GJA1, CALCA
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.2CSF2, GH1, IGF1, IL4, IL2, IL12B
9response to lipopolysaccharideGO:03249610.2F3, EDN1, FAS, IL13, IL12A, MMP9
10cell surface receptor signaling pathwayGO:00716610.1ERBB2, F2, IFNG, NPPB, PRL, CCL2
11defense response to Gram-negative bacteriumGO:05082910.0IL6, SELP, SERPINE1, IL12B, CAMP, NOS2
12signal transductionGO:00716510.0CHRNE, CCL11, CCL13, IGF1, GATA3, ADM
13positive regulation of T cell proliferationGO:04210210.0IL12B, IL12A, PTPRC, VCAM1, IFNG, CCL5
14response to ethanolGO:04547110.0CCL2, BGLAP, AVP, MMP9, IL13, NOS3
15negative regulation of growth of symbiont in hostGO:0441309.9CAMP, TLR2, ELANE, LTA, IL12B, IFNG
16regulation of blood pressureGO:0082179.9UTS2, ACE, POMC, NPPA, NPPB, MYH6
17cell adhesionGO:0071559.8STAB1, POSTN, PECAM1, DSG2, DSC2, ACHE
18positive regulation of interferon-gamma productionGO:0327299.7CD40LG, TLR4, LTA, TNF, IL2, IL12RB2
19negative regulation of apoptotic processGO:0430669.6TIMP1, EGFR, PF4, PLAUR, TNF, TP53
20platelet degranulationGO:0025769.5F5, ALB, PF4, TIMP1, TGFB1, SOD1
21agingGO:0075689.5FAS, CCL2, IL1B, VCAM1, TGFB1, CCL5
22positive regulation of nitric oxide biosynthetic processGO:0454299.2EDN1, IL1B, IFNG, INS, TNF, PTGS2
23platelet activationGO:0301689.1F2, ALB, PF4, TIMP1, TGFB1, TF
24positive regulation of cell proliferationGO:0082849.1F2, IGF1, IL6, IL3, IL2, IL12RB2
25response to estradiol stimulusGO:0323559.1MMP9, IL1B, ENO2, F3, NOS3, GH1
26positive regulation of smooth muscle cell proliferationGO:0486618.9IL13, IL6, CCL5, IGF1, TNF, PTGS2
27response to glucocorticoid stimulusGO:0513848.6CCL5, SERPINE1, ADM, OXT, PLAT, PTGDS
28lipopolysaccharide-mediated signaling pathwayGO:0316638.3TGFB1, TLR4, TLR2, CCL2, IL1B, CCL5
29response to hypoxiaGO:0016668.2ADM, MMP9, IL1B, FAS, CCL2, TNF
30positive regulation of transcription from RNA polymerase II promoterGO:0459447.9S1PR1, IL17A, CDKN2A, CD40, FGF2, CGA
31inflammatory responseGO:0069547.6NFKB1, CRP, CRH, SPP1, CYSLTR1, PTGS2
32response to drugGO:0424937.5SOD1, NPPB, SLC6A4, NME1, GATA3, CCND1
33blood coagulationGO:007596INFVWF, TP53, PLAT, PLAU, PLAUR, NOS2
34innate immune responseGO:045087INFCTSB, TLR9, TLR2, NFKB1, CRISP3, DMBT1
35positive regulation of isotype switching to IgG isotypesGO:048304INF, PTPRC, IFNG, CD40, IL2, IL4
36anti-apoptosisGO:006916INFBCL2L1, CD40LG, SOD1, , NFKB1, NOS3
37positive regulation of NF-kappaB transcription factor activityGO:051092INFTNFRSF8, NFKB1, TLR2, TLR4, TLR9, TGFB1
38apoptotic processGO:006915INF, VIM, BIRC5, , BCL2L1, BAX
39positive regulation of MAP kinase activityGO:043406INFTNF, , EDN1, EGFR, ELANE, VEGFA

Molecular functions related to sinusitis according to GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:005515INFNR3C1, GH1, GJA1, AKT1S1, HPSE, CALCA
2heparin bindingGO:00820110.4SELL, VEGFA, FGF2, APOH, CCL7, CCL2
3receptor bindingGO:00510210.1CCL2, CCL13, AMACR, F2, CALCA, NPPA
4hormone activityGO:00517910.1CRH, EDN1, PRL, POMC, ADM, NPPA
5protein heterodimerization activityGO:0469829.3VEGFA, IL12B, MYH6, MYC, ADRB1, NKX2-5
6growth factor activityGO:0080839.2CSF3, BMP6, VEGFA, CSF2, BMP7, TGFB1
7cytokine activityGO:0051259.1TNF, SPP1, LTA, EDN1, CSF2, CSF3
8identical protein bindingGO:042802INFERBB2, TP53, TP63, BCL2L1, TP73, TNF

Sources for Sinusitis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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