MCID: SNS014
MIFTS: 57

Sinusitis malady

Respiratory diseases category

Summaries for Sinusitis

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MedlinePlus:33 Sinusitis means your sinuses are inflamed. the cause can be an infection or another problem. your sinuses are hollow air spaces within the bones surrounding the nose. they produce mucus, which drains into the nose. if your nose is swollen, this can block the sinuses and cause pain. there are several types of sinusitis, including acute, which lasts up to 4 weeks subacute, which lasts 4 to 12 weeks chronic, which lasts more than 12 weeks and can continue for months or even years recurrent, with several attacks within a year acute sinusitis often starts as a cold, which then turns into a bacterial infection. allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. there may also be mucus drainage in the back of the throat, called postnasal drip. your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. you may also need imaging tests. treatments include antibiotics, decongestants, and pain relievers. using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help. nih: national institute of allergy and infectious diseases

MalaCards based summary: Sinusitis is related to tonsillitis and bronchitis. An important gene associated with Sinusitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are TSLP Signaling Pathway and Inflammatory Response Pathway. The drugs ciprofloxacin and guaifenesin and the compounds unicap and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:64 Sinusitis, also known as rhinosinusitis, is inflammation of the paranasal sinuses. It can be due to... more...

Aliases & Classifications for Sinusitis

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Sinusitis, Aliases & Descriptions:

Name: Sinusitis 31 11 44 33 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Related Diseases for Sinusitis

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Diseases in the Sinusitis family:

Acute Frontal Sinusitis Chronic Frontal Sinusitis
Frontal Sinusitis

Diseases related to Sinusitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 446)
idRelated DiseaseScoreTop Affiliating Genes
1tonsillitis31.1LACTB
2bronchitis31.0RNASE3
3meningitis31.0LACTB, IL8
4otitis media30.8CCL11, RNASE3, LACTB
5allergic bronchopulmonary aspergillosis30.7IL4, CFTR, IL5
6common cold30.7RNASE3, IL8, CCL11
7prostatitis30.7LACTB
8rhinitis30.6RNASE3, CCL11, IL8, IL5, IL4
9conjunctivitis30.5RNASE3
10bronchiectasis30.5RNASE3, IL8, CFTR
11bacterial meningitis30.4LACTB, IL8
12allergic rhinitis30.3CCL11, RNASE3, IL5, IL4, IL8
13influenza30.2CFTR, CCL11, LACTB
14esophagitis30.1CCL11, IL5
15intrinsic asthma30.0IL4, IL5, RNASE3
16eosinophilia30.0IL8, IL5, IL4, CCL11, RNASE3
17urticaria29.9RNASE3, LTC4S
18angioedema29.9LTC4S, IL5, RNASE3
19tuberculosis29.8IL4, LACTB, CYP2B6, DEFB4A
20food allergy29.8CCL11, IL4, IL5, RNASE3
21atopy29.7CCL11, RNASE3, IL5, IL4, LTC4S
22melanoma29.7CFTR, IL4, CCL11, IL8, LACTB
23cystic fibrosis29.7RNASE3, LACTB, CFTR, IL8, DEFB4A, PI3
24uveitis29.7CCL11, IL4
25asthma29.6DEFB4A, IL4, RNASE3, CCL11, IL5, IL8
26sepsis29.3DEFB4A, PI3, LACTB, IL8
27leukemia29.3LTC4S, CFTR, CYP2B6, IL4, RNASE3, CCL11
28pneumonia29.2LACTB, DEFB4A, PI3, CFTR, CCL11, IL5
29frontal sinusitis11.0
30chronic maxillary sinusitis10.9
31acute maxillary sinusitis10.9
32sphenoid sinusitis10.8
33acute frontal sinusitis10.7
34chronic frontal sinusitis10.6
35inverted papilloma10.6
36papilloma10.6
37ethmoid sinusitis10.6
38gastroenteritis10.5LACTB
39cellulitis10.5
40paragonimiasis10.5IL5
41endophthalmitis10.5LACTB
42orbital cellulitis10.5
43strongyloidiasis10.5IL5
44aspergillosis10.5
45acute sphenoidal sinusitis10.4
46osteomyelitis10.4
47subdural empyema10.4
48cavernous sinus thrombosis10.4
49keratoconjunctivitis sicca10.4CFTR
50fibroma10.4

Graphical network of the top 20 diseases related to Sinusitis:



Diseases related to sinusitis

Symptoms for Sinusitis

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Drugs & Therapeutics for Sinusitis

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Genetic Tests for Sinusitis

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Anatomical Context for Sinusitis

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MalaCards organs/tissues related to Sinusitis:

32
Bone, Testes, Brain, Tonsil, Lymph node, T cells, Pituitary, Neutrophil, Lung, Myeloid, Breast, Bone marrow, Colon, Thyroid, Skin, Prostate, B cells, Endothelial, Eye, Spinal cord, Salivary gland, Monocytes

Animal Models for Sinusitis or affiliated genes

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MGI Mouse Phenotypes related to Sinusitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2LTC4S, IL5, IL4, CCL11, CFTR
2MP:00053878.1CCL11, IL4, IL5, IL8, LTC4S, CFTR

Publications for Sinusitis

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Articles related to Sinusitis:

(show top 50)    (show all 1551)
idTitleAuthorsYear
1
Reconstructed bone chip detachment is a risk factor for sinusitis after transsphenoidal surgery. (24375023)
2014
2
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
3
Intranasal steroids for acute sinusitis. (24293353)
2013
4
Acute sphenoid sinusitis leading to contralateral cavernous sinus thrombosis: a case report. (23883649)
2013
5
Quadrupedal head position enhances recovery from chronic maxillary sinusitis. (23731852)
2013
6
Acute sinusitis in adults--reply. (23712408)
2013
7
Comparison of clinical data, CT, and bone histopathology in unilateral chronic maxillary sinusitis. (23112270)
2013
8
Cryptococcal meningitis presenting as sinusitis in a renal transplant recipient. (24034280)
2013
9
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. (22118926)
2012
10
Inverted papilloma with associated carcinoma of the nasal cavity and paranasal sinuses: treatment outcomes. (22035165)
2012
11
Miller Fisher variant of Guillain-BarrAc syndrome masquerading as acute sphenoid sinusitis with orbital apex syndrome. (22447677)
2012
12
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
13
Sinus augmentation surgery after endoscopic sinus surgery for the treatment of chronic maxillary sinusitis: a case report. (21869684)
2011
14
Pott's puffy tumor, intracranial, and orbital complications as the initial presentation of sinusitis in healthy adolescents, a case series. (21380513)
2011
15
Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. (22461817)
2011
16
Microbiology of acute complicated bacterial sinusitis at the University of the Witwatersrand. (20822623)
2010
17
Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. (21154389)
2010
18
Subcutaneous emphysema in a case of infective sinusitis: a case report. (20678214)
2010
19
Incidence and presentation of fungal sinusitis in patient diagnosed with chronic rhinosinusitis. (22319697)
2010
20
Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis. (19910027)
2009
21
Endoscopic frontal sinus septectomy in the treatment of unilateral frontal sinusitis: revisiting an open technique. (19958729)
2009
22
Balloon sinuplasty in acute frontal sinusitis. (19936361)
2009
23
Subdural empyema complicating sinusitis. (18155385)
2008
24
Initial surgical treatment for chronic frontal sinusitis: a pilot study. (17491529)
2007
25
Frequency of recovery of pathogens causing acute maxillary sinusitis in adults before and after introduction of vaccination of children with the 7-valent pneumococcal vaccine. (16772423)
2006
26
The role of bacterial interference in otitis, sinusitis and tonsillitis. (16025067)
2005
27
Analysis of the sinusitis nasal lavage fluid proteome using capillary liquid chromatography interfaced to electrospray ionization-quadrupole time of flight- tandem mass spectrometry. (15174061)
2004
28
First case of Arthrographis kalrae ethmoid sinusitis and ophthalmitis in the People's Republic of China. (15472353)
2004
29
Management of acute maxillary sinusitis in Finnish primary care. Results from the nationwide MIKSTRA study. (15255494)
2004
30
Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis. (11577554)
2002
31
Intracranial complications of frontal sinusitis in children: Pott's puffy tumor revisited. (11549918)
2001
32
Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. (11561799)
2001
33
Experimental myospherulosis of the paranasal sinuses: a histologic rabbit study. (10793918)
2000
34
Lactoferrin and eosinophilic cationic protein in nasal secretions of patients with experimental rhinovirus colds, natural colds, and presumed acute community-acquired bacterial sinusitis. (10921988)
2000
35
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
36
Sinusitis in the common cold. (9768580)
1998
37
Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism. (9674310)
1998
38
IL-4 and IL-13 expression in chronic sinusitis: relationship with cellular infiltrate and effect of topical corticosteroid treatment. (9176799)
1997
39
Antimicrobial treatment of sinusitis. (1771306)
1991
40
Bacteriology of chronic maxillary sinusitis in adults. (2729825)
1989
41
Serological evidence of viral or Mycoplasma pneumoniae infection in acute maxillary sinusitis. (2498094)
1989
42
Sphenoid sinusitis presenting as chronic meningitis. (3699068)
1986
43
Effects of phenylpropanolamine on ostial and nasal patency in patients treated for chronic maxillary sinusitis. (3727982)
1986
44
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
45
Conservative therapy for right frontal sinusitis in a Brahman bull. (6917610)
1982
46
Spontaneous enophthalmos associated with chronic maxillary sinusitis. (7301315)
1981
47
Nursing care study--acute frontal sinusitis with associated osteitis. (281656)
1978
48
Primary dextrocardia with situs inversus, associated with sinusitis and bronchitis in a dog. (4857725)
1974
49
Bacteriological findings in acute maxillary sinusitis. (4405604)
1972
50
OEdema of Conjunctiva from Acute Frontal Sinusitis. (19975137)
1911

Variations for Sinusitis

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Expression for genes affiliated with Sinusitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Sinusitis patients vs. healthy controls: 31 (show all 216)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1FDCSPfollicular dendritic cell secreted proteinNose+5.870.000
2MUC7mucin 7, secretedNose+5.430.001
3PIPprolactin-induced proteinNose+5.280.000
4STATHstatherinNose+5.170.000
5KRT14keratin 14Nose+4.900.000
6CRISP3cysteine-rich secretory protein 3Nose+4.460.007
7C6orf58chromosome 6 open reading frame 58Nose+4.300.002
8BPIFB2BPI fold containing family B, member 2Nose+4.260.002
9IGHMimmunoglobulin heavy constant muNose+4.220.000
10ZG16Bzymogen granule protein 16BNose+3.910.000
11LOC285628uncharacterized LOC285628Nose+3.850.000
12CXCL13chemokine (C-X-C motif) ligand 13Nose+3.840.001
13AZGP1alpha-2-glycoprotein 1, zinc-bindingNose+3.780.001
14SEC14L3SEC14-like 3 (S. cerevisiae)Nose-3.720.000
15TCN1transcobalamin I (vitamin B12 binding protein, R binder family)Nose+3.700.000
16DSG3desmoglein 3Nose+3.650.000
17DMBT1deleted in malignant brain tumors 1Nose+3.650.003
18SCGB1A1secretoglobin, family 1A, member 1 (uteroglobin)Nose-3.610.000
19GREM2gremlin 2, DAN family BMP antagonistNose-3.600.002
20SLC26A4solute carrier family 26 (anion exchanger), member 4Nose+3.550.001
21PRB3proline-rich protein BstNI subfamily 3Nose+3.550.001
22LTFlactotransferrinNose+3.490.008
23FLJ26850FLJ26850 proteinNose-3.490.000
24NCAPGnon-SMC condensin I complex, subunit GNose+3.480.000
25DUOX2dual oxidase 2Nose+3.430.007
26MUC5Bmucin 5B, oligomeric mucus/gel-formingNose+3.410.000
27LPOlactoperoxidaseNose+3.310.003
28C15orf48chromosome 15 open reading frame 48Nose+3.290.001
29STK33serine/threonine kinase 33Nose-3.280.008
30CXCL5chemokine (C-X-C motif) ligand 5Nose+3.200.001
31CXorf57chromosome X open reading frame 57Nose-3.160.002
32ODAModontogenic, ameloblast asssociatedNose+3.120.007
33IDO1indoleamine 2,3-dioxygenase 1Nose+3.110.011
34TFtransferrinNose+3.110.000
35CHI3L1chitinase 3-like 1 (cartilage glycoprotein-39)Nose+3.110.003
36PRB4proline-rich protein BstNI subfamily 4Nose+3.090.005
37LRP1Blow density lipoprotein receptor-related protein 1BNose-3.060.003
38CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Nose-3.040.001
39HPhaptoglobinNose+2.970.011
40ANXA1annexin A1Nose-2.970.000
41SERPINA3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Nose+2.970.008
42KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16Nose-2.960.002
43F5coagulation factor V (proaccelerin, labile factor)Nose+2.890.001
44NR4A3nuclear receptor subfamily 4, group A, member 3Nose-2.880.015
45TEP1telomerase-associated protein 1Nose+2.870.016
46PDE4DIPphosphodiesterase 4D interacting proteinNose-2.800.001
47SERPINB4serpin peptidase inhibitor, clade B (ovalbumin), member 4Nose+2.800.002
48ALS2CR12amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12Nose-2.790.018
49LYZlysozymeNose+2.790.001
50WDR96WD repeat domain 96Nose-2.780.023
51PRR4proline rich 4 (lacrimal)Nose+2.770.010
52ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Nose+2.770.006
53OLFM4olfactomedin 4Nose+2.740.014
54S100A8S100 calcium binding protein A8Nose+2.720.026
55CA12carbonic anhydrase XIINose+2.670.009
56TEKT3tektin 3Nose-2.660.011
57DNAH2dynein, axonemal, heavy chain 2Nose-2.650.028
58LPHN3latrophilin 3Nose-2.620.002
59TBX1T-box 1Nose+2.600.002
60FGF14fibroblast growth factor 14Nose-2.580.036
61HTN3histatin 3Nose+2.580.024
62CLCA4chloride channel accessory 4Nose+2.530.015
63ATP2A3ATPase, Ca++ transporting, ubiquitousNose+2.500.016
64DNAH9dynein, axonemal, heavy chain 9Nose-2.500.020
65SPAG8sperm associated antigen 8Nose-2.480.011
66FZD8frizzled class receptor 8Nose+2.480.006
67DHX35DEAH (Asp-Glu-Ala-His) box polypeptide 35Nose-2.460.032
68TOP2Atopoisomerase (DNA) II alpha 170kDaNose+2.460.013
69ZNF417zinc finger protein 417Nose+2.450.029
70APOL6apolipoprotein L, 6Nose+2.450.017
71IL32interleukin 32Nose+2.440.034
72FSD1Lfibronectin type III and SPRY domain containing 1-likeNose-2.410.022
73PDZK1IP1PDZK1 interacting protein 1Nose+2.400.017
74AP2A1adaptor-related protein complex 2, alpha 1 subunitNose+2.400.033
75TTC16tetratricopeptide repeat domain 16Nose-2.400.029
76PGFplacental growth factorNose+2.390.016
77C1orf168chromosome 1 open reading frame 168Nose-2.380.006
78HOXD3homeobox D3Nose+2.380.049
79PBX1pre-B-cell leukemia homeobox 1Nose-2.380.005
80CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Nose+2.380.009
81RTN2reticulon 2Nose+2.370.001
82KYNUkynureninaseNose+2.360.014
83IGLV2-23immunoglobulin lambda variable 2-23Nose+2.350.027
84PMLpromyelocytic leukemiaNose+2.350.004
85SBNO2strawberry notch homolog 2 (Drosophila)Nose+2.350.020
86WDR16WD repeat domain 16Nose-2.350.013
87LCN2lipocalin 2Nose+2.350.004
88DRC1dynein regulatory complex subunit 1 homolog (Chlamydomonas)Nose-2.340.048
89MED18mediator complex subunit 18Nose+2.330.034
90DNAH5dynein, axonemal, heavy chain 5Nose-2.330.011
91TRDT cell receptor delta locusNose+2.320.047
92NOX1NADPH oxidase 1Nose+2.320.031
93GSTA3glutathione S-transferase alpha 3Nose-2.310.029
94CCDC173coiled-coil domain containing 173Nose-2.310.011
95ADH6alcohol dehydrogenase 6 (class V)Nose-2.300.029
96KCNN3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3Nose-2.290.012
97SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2Nose-2.290.000
98PROS1protein S (alpha)Nose-2.260.011
99C11orf82chromosome 11 open reading frame 82Nose+2.250.000
100NTSneurotensinNose-2.230.047
101COLQcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesteraseNose-2.230.031
102DHFRdihydrofolate reductaseNose+2.230.025
103ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideNose+2.220.045
104USP51ubiquitin specific peptidase 51Nose-2.220.005
105CES4Acarboxylesterase 4ANose-2.220.018
106LZTS2leucine zipper, putative tumor suppressor 2Nose+2.210.023
107KLF6Kruppel-like factor 6Nose-2.210.012
108EPHX4epoxide hydrolase 4Nose+2.190.016
109TPX2TPX2, microtubule-associatedNose+2.190.002
110HCAR3hydroxycarboxylic acid receptor 3Nose-2.180.012
111KIF6kinesin family member 6Nose-2.170.044
112CCDC30coiled-coil domain containing 30Nose-2.160.019
113PTHLHparathyroid hormone-like hormoneNose+2.160.031
114MCM10minichromosome maintenance complex component 10Nose+2.150.011
115TTC18tetratricopeptide repeat domain 18Nose-2.150.038
116S100A9S100 calcium binding protein A9Nose+2.150.032
117FKBP8FK506 binding protein 8, 38kDaNose+2.140.023
118ERICH5glutamate-rich 5Nose-2.140.036
119C8orf34chromosome 8 open reading frame 34Nose-2.140.003
120DLGAP5discs, large (Drosophila) homolog-associated protein 5Nose+2.130.025
121SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Nose-2.130.011
122MAOBmonoamine oxidase BNose-2.130.005
123C4orf47chromosome 4 open reading frame 47Nose-2.130.039
124UMODL1uromodulin-like 1Nose-2.120.021
125SLC34A2solute carrier family 34 (type II sodium/phosphate contransporter), member 2Nose+2.120.029
126SOX10SRY (sex determining region Y)-box 10Nose+2.110.032
127PRSS33protease, serine, 33Nose+2.100.031
128SLCO1B3solute carrier organic anion transporter family, member 1B3Nose+2.080.044
129PPP1R14Cprotein phosphatase 1, regulatory (inhibitor) subunit 14CNose-2.080.033
130ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptideNose-2.080.015
131PRB1proline-rich protein BstNI subfamily 1Nose+2.080.049
132NSUN7NOP2/Sun domain family, member 7Nose-2.080.007
133IGKV3-20immunoglobulin kappa variable 3-20Nose+2.080.038
134RYR3ryanodine receptor 3Nose-2.070.011
135PACS1phosphofurin acidic cluster sorting protein 1Nose+2.070.009
136FGF18fibroblast growth factor 18Nose-2.060.041
137SLC6A13solute carrier family 6 (neurotransmitter transporter), member 13Nose-2.040.037
138KIF20Akinesin family member 20ANose+2.040.021
139MYH11myosin, heavy chain 11, smooth muscleNose+2.040.034
140ATXN7L2ataxin 7-like 2Nose+2.030.038
141DSC2desmocollin 2Nose+2.020.008
142SF3A2splicing factor 3a, subunit 2, 66kDaNose+2.020.022
143DNAH6dynein, axonemal, heavy chain 6Nose-2.020.047
144CAPS2calcyphosine 2Nose-2.020.016
145AADACarylacetamide deacetylaseNose-2.020.026
146KCNQ1OT1KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)Nose-2.020.025
147HSPG2heparan sulfate proteoglycan 2Nose+2.020.035
148KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1Nose-2.020.044
149ADAadenosine deaminaseNose+2.020.020
150ZBBXzinc finger, B-box domain containingNose-2.010.048
151KATNAL2katanin p60 subunit A-like 2Nose-2.010.016
152MMP14matrix metallopeptidase 14 (membrane-inserted)Nose+2.000.014
153YPEL3yippee-like 3 (Drosophila)Nose+1.990.011
154FAM46Cfamily with sequence similarity 46, member CNose-1.970.023
155DNAJC12DnaJ (Hsp40) homolog, subfamily C, member 12Nose+1.970.023
156CNOT3CCR4-NOT transcription complex, subunit 3Nose+1.970.033
157SLAMF7SLAM family member 7Nose+1.960.012
158MAFFv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog FNose-1.960.017
159MYO9Bmyosin IXBNose+1.940.026
160CFBcomplement factor BNose+1.940.017
161LUZP4leucine zipper protein 4Nose+1.940.049
162TXLNBtaxilin betaNose-1.930.023
163TNFAIP2tumor necrosis factor, alpha-induced protein 2Nose+1.930.016
164GINS2GINS complex subunit 2 (Psf2 homolog)Nose+1.930.041
165CR2complement component (3d/Epstein Barr virus) receptor 2Nose+1.920.030
166MARCH10membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligaseNose-1.920.045
167BRIP1BRCA1 interacting protein C-terminal helicase 1Nose+1.920.015
168TPP1tripeptidyl peptidase INose+1.920.043
169AKAP5A kinase (PRKA) anchor protein 5Nose+1.920.042
170CSRP2cysteine and glycine-rich protein 2Nose-1.910.021
171RORBRAR-related orphan receptor BNose-1.900.024
172ERBB4v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4Nose-1.890.001
173RGS20regulator of G-protein signaling 20Nose+1.890.041
174PPP1R1Bprotein phosphatase 1, regulatory (inhibitor) subunit 1BNose+1.890.042
175KCND3potassium voltage-gated channel, Shal-related subfamily, member 3Nose+1.870.047
176MAATS1MYCBP-associated, testis expressed 1Nose-1.860.030
177SPI1spleen focus forming virus (SFFV) proviral integration oncogeneNose+1.850.050
178FCRL5Fc receptor-like 5Nose+1.840.039
179LRRC46leucine rich repeat containing 46Nose-1.830.041
180THSD4thrombospondin, type I, domain containing 4Nose-1.820.020
181MICALL1MICAL-like 1Nose+1.820.027
182PNCKpregnancy up-regulated nonubiquitous CaM kinaseNose+1.810.023
183CCL28chemokine (C-C motif) ligand 28Nose+1.810.025
184CXCL2chemokine (C-X-C motif) ligand 2Nose-1.800.033
185CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)Nose-1.800.006
186DNMT3ADNA (cytosine-5-)-methyltransferase 3 alphaNose+1.800.044
187OSBPL6oxysterol binding protein-like 6Nose-1.800.027
188CPNE5copine VNose+1.790.028
189SFRP1secreted frizzled-related protein 1Nose-1.780.042
190CCNA2cyclin A2Nose+1.780.029
191TRIM47tripartite motif containing 47Nose+1.780.024
192SAA4serum amyloid A4, constitutiveNose+1.780.036
193ENPEPglutamyl aminopeptidase (aminopeptidase A)Nose-1.760.034
194ATF3activating transcription factor 3Nose-1.760.023
195C2orf40chromosome 2 open reading frame 40Nose-1.750.039
196FOXP2forkhead box P2Nose-1.750.004
197ANLNanillin, actin binding proteinNose+1.740.033
198PPP1R36protein phosphatase 1, regulatory subunit 36Nose-1.740.049
199TMEM45Atransmembrane protein 45ANose+1.740.043
200KIAA1377KIAA1377Nose-1.740.037
201RGAG4retrotransposon gag domain containing 4Nose-1.740.009
202CCDC114coiled-coil domain containing 114Nose-1.740.042
203ADCY1adenylate cyclase 1 (brain)Nose+1.730.029
204SH2D1BSH2 domain containing 1BNose+1.730.042
205IER3immediate early response 3Nose-1.720.029
206SLC6A8solute carrier family 6 (neurotransmitter transporter), member 8Nose+1.690.049
207TPM4tropomyosin 4Nose+1.680.044
208ATP10BATPase, class V, type 10BNose+1.680.013
209LYPD6BLY6/PLAUR domain containing 6BNose-1.670.048
210PLATplasminogen activator, tissueNose+1.670.018
211MAP3K8mitogen-activated protein kinase kinase kinase 8Nose-1.640.036
212TTLL9tubulin tyrosine ligase-like family, member 9Nose-1.640.046
213DPY19L2dpy-19-like 2 (C. elegans)Nose-1.600.029
214YBX2Y box binding protein 2Nose+1.590.034
215MICBMHC class I polypeptide-related sequence BNose+1.520.049
216HELBhelicase (DNA) BNose+1.510.039

Expression patterns in normal tissues for genes affiliated with Sinusitis

Search GEO for disease gene expression data for Sinusitis.

Pathways for genes affiliated with Sinusitis

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Pathways related to Sinusitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL8, CCL11
29.8IL4, IL5
39.8IL5, IL4
49.8IL4, IL5
59.8IL5, IL4
6
Show member pathways
9.6IL8, CFTR
79.4IL5, IL4, CCL11
8
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.4IL8, IL5, IL4
99.4IL8, IL5, IL4
109.4IL8, IL5, IL4
11
Show member pathways
9.3IL8, CCL11, CFTR
12
Show member pathways
9.2RNASE3, CCL11, IL4, IL5
139.1CCL11, IL4, IL5, IL8
14
Show member pathways
9.1CCL11, IL4, IL5, IL8
15
Show member pathways
9.1CCL11, IL4, IL5, IL8
16
Show member pathways
9.1CCL11, IL4, IL5, IL8
17
Show member pathways
9.1IL8, IL5, IL4, CCL11
18
Show member pathways
8.5CCL11, IL4, IL5, IL8, LTC4S
19
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.1IL8, IL4, CCL11, CFTR, DEFB4A

Compounds for genes affiliated with Sinusitis

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Compounds related to Sinusitis according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1unicap4410.0RNASE3, IL5, CCL11
2sodium cromoglycate449.9RNASE3, CCL11, IL5
3levocetirizine449.8CCL11, IL8, IL4
4epinastine44 1210.7CYP2B6, IL5, IL4
5ketotifen44 1210.7IL5, CCL11, RNASE3
6formoterol44 29 1211.7IL4, IL8, RNASE3
7praziquantel44 1210.6RNASE3, IL5, IL4
8cetirizine44 29 25 1212.6IL8, IL5, RNASE3, CCL11
9salbutamol44 50 29 25 1213.6CCL11, RNASE3, IL8, IL5
10pranlukast44 29 1211.6IL4, IL5, CCL11, RNASE3
11roxithromycin44 29 1211.6IL8, CYP2B6, CCL11, IL5
12azelastine44 1210.5RNASE3, CYP2B6, IL5, IL4
13nedocromil sodium449.5IL5, IL4, RNASE3, IL8
14n-formylmethionyl-leucylphenylalanine449.5CCL11, IL8, RNASE3, IL5
15itraconazole44 1210.5IL5, IL4, CYP2B6
16lte4449.5CCL11, RNASE3, IL5, LTC4S
17allergens449.5RNASE3, IL5, CCL11, IL4
18ltc4449.4LTC4S, RNASE3, CCL11, IL5
19rolipram44 60 2911.4IL8, IL5, IL4, CCL11
20poly(i-c)449.4IL4, IL5, IL8, CCL11
21pgd2449.4RNASE3, LTC4S, CCL11, IL5
22tarc449.4IL8, IL5, IL4, CCL11
23ltd4449.4RNASE3, IL5, LTC4S
24clarithromycin44 1210.4LACTB, IL8, IL5, CCL11
25azithromycin44 1210.3LACTB, CFTR, IL8
26erythromycin44 3 50 1212.2CYP2B6, LACTB, IL8, IL5
27salmeterol44 50 29 1212.2RNASE3, CCL11, IL4, IL5, IL8
28budesonide44 50 1211.2RNASE3, IL5, IL4, CCL11, IL8
29fluticasone propionate44 50 60 1212.2IL4, RNASE3, CCL11, IL5, IL8
30methacholine44 50 1211.2CCL11, RNASE3, IL8, IL4, IL5
31il-12449.1IL8, IL5, IL4
32anti-fungal449.1RNASE3, CYP2B6, DEFB4A, IL5
33herbimycin a44 6010.1IL5, IL8, CCL11, IL4
34n acetylcysteine448.9CFTR, IL4, RNASE3, IL8, CCL11
35indomethacin44 29 60 1211.9CCL11, CFTR, IL4, IL5, CYP2B6
36hbd2448.9IL8, DEFB4A, PI3
37aspirin44 50 29 2511.8LTC4S, IL4, CCL11, RNASE3, CFTR
38leukotriene b444 60 2510.8CYP2B6, RNASE3, CCL11, IL5, IL8, LTC4S
39montelukast44 50 29 1211.7IL5, RNASE3, CCL11, IL4, LTC4S, IL8
40ly294002448.6IL8, PI3, CCL11, IL4, IL5
41rantes448.4DEFB4A, RNASE3, IL5, IL4, CCL11, IL8
42pge2448.2CFTR, IL4, RNASE3, CCL11, LTC4S, IL5
43genistein44 29 60 3 25 1213.1CFTR, DEFB4A, CCL11, IL5, IL8
44sb 20358044 609.0DEFB4A, IL4, PI3, IL8, CCL11, IL5
45cyclosporin a44 29 609.8IL4, IL5, IL8, CCL11, RNASE3, CFTR
46retinoic acid44 258.7RNASE3, CCL11, CYP2B6, CFTR, PI3, DEFB4A
47cysteine447.3LTC4S, IL8, IL5, DEFB4A, IL4, CFTR
48histamine44 29 259.3RNASE3, IL8, LTC4S, IL5, IL4, CCL11
49tyrosine447.2LTC4S, DEFB4A, PI3, CYP2B6, RNASE3, CCL11
50dexamethasone44 50 29 129.5CYP2B6, IL5, LTC4S, IL8, PI3, IL4

GO Terms for genes affiliated with Sinusitis

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Cellular components related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1IL8, IL5, IL4, CCL11
2extracellular regionGO:0055768.1IL8, IL5, CCL11, RNASE3, DEFB4A

Biological processes related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.7IL5, IL4
2response to cytokineGO:0340979.6IL4, CFTR
3inflammatory responseGO:0069549.2IL8, IL5, CCL11
4chemotaxisGO:0069358.6DEFB4A, CCL11, IL4, IL8
5immune responseGO:0069558.3IL8, IL5, IL4, CCL11, DEFB4A

Molecular functions related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8IL8, CCL11

Products for genes affiliated with Sinusitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Sinusitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet