MCID: SNS014
MIFTS: 58

Sinusitis malady

Respiratory diseases category
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Summaries for Sinusitis

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MedlinePlus:33 Sinusitis means your sinuses are inflamed. the cause can be an infection or another problem. your sinuses are hollow air spaces within the bones surrounding the nose. they produce mucus, which drains into the nose. if your nose is swollen, this can block the sinuses and cause pain. there are several types of sinusitis, including acute, which lasts up to 4 weeks subacute, which lasts 4 to 12 weeks chronic, which lasts more than 12 weeks and can continue for months or even years recurrent, with several attacks within a year acute sinusitis often starts as a cold, which then turns into a bacterial infection. allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. there may also be mucus drainage in the back of the throat, called postnasal drip. your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. you may also need imaging tests. treatments include antibiotics, decongestants, and pain relievers. using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help. nih: national institute of allergy and infectious diseases

MalaCards based summary: Sinusitis is related to tonsillitis and bronchitis. An important gene associated with Sinusitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are TSLP Signaling Pathway and Inflammatory Response Pathway. The drugs ciprofloxacin and pseudoephedrine and the compounds unicap and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:65 Sinusitis, also known as rhinosinusitis, is inflammation of the paranasal sinuses. It can be due to... more...

Aliases & Classifications for Sinusitis

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Sinusitis, Aliases & Descriptions:

Name: Sinusitis 30 10 44 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Related Diseases for Sinusitis

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Diseases in the Sinusitis family:

Acute Frontal Sinusitis Chronic Frontal Sinusitis
Frontal Sinusitis

Diseases related to Sinusitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 446)
idRelated DiseaseScoreTop Affiliating Genes
1tonsillitis31.1LACTB
2bronchitis31.0RNASE3
3meningitis31.0LACTB, IL8
4otitis media30.8CCL11, RNASE3, LACTB
5allergic bronchopulmonary aspergillosis30.7IL4, CFTR, IL5
6common cold30.7RNASE3, IL8, CCL11
7prostatitis30.7LACTB
8rhinitis30.6RNASE3, CCL11, IL8, IL5, IL4
9conjunctivitis30.5RNASE3
10bronchiectasis30.5RNASE3, IL8, CFTR
11bacterial meningitis30.4LACTB, IL8
12allergic rhinitis30.3CCL11, RNASE3, IL5, IL4, IL8
13influenza30.2CFTR, CCL11, LACTB
14esophagitis30.1CCL11, IL5
15intrinsic asthma30.0IL4, IL5, RNASE3
16eosinophilia30.0IL8, IL5, IL4, CCL11, RNASE3
17urticaria29.9RNASE3, LTC4S
18angioedema29.9LTC4S, IL5, RNASE3
19tuberculosis29.8IL4, LACTB, CYP2B6, DEFB4A
20food allergy29.8CCL11, IL4, IL5, RNASE3
21atopy29.7CCL11, RNASE3, IL5, IL4, LTC4S
22melanoma29.7CFTR, IL4, CCL11, IL8, LACTB
23cystic fibrosis29.7RNASE3, LACTB, CFTR, IL8, DEFB4A, PI3
24uveitis29.7CCL11, IL4
25asthma29.6DEFB4A, IL4, RNASE3, CCL11, IL5, IL8
26sepsis29.3DEFB4A, PI3, LACTB, IL8
27leukemia29.3LTC4S, CFTR, CYP2B6, IL4, RNASE3, CCL11
28pneumonia29.2LACTB, DEFB4A, PI3, CFTR, CCL11, IL5
29frontal sinusitis11.0
30chronic maxillary sinusitis10.9
31acute maxillary sinusitis10.9
32sphenoid sinusitis10.8
33acute frontal sinusitis10.7
34chronic frontal sinusitis10.6
35inverted papilloma10.6
36papilloma10.6
37ethmoid sinusitis10.6
38gastroenteritis10.5LACTB
39cellulitis10.5
40paragonimiasis10.5IL5
41endophthalmitis10.5LACTB
42orbital cellulitis10.5
43strongyloidiasis10.5IL5
44aspergillosis10.5
45acute sphenoidal sinusitis10.4
46osteomyelitis10.4
47subdural empyema10.4
48cavernous sinus thrombosis10.4
49keratoconjunctivitis sicca10.4CFTR
50fibroma10.4

Graphical network of the top 20 diseases related to Sinusitis:



Diseases related to sinusitis

Symptoms for Sinusitis

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Drugs & Therapeutics for Sinusitis

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Genetic Tests for Sinusitis

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Anatomical Context for Sinusitis

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MalaCards organs/tissues related to Sinusitis:

32
Bone, Testes, Brain, Tonsil, Lymph node, T cells, Pituitary, Neutrophil, Lung, Myeloid, Breast, Bone marrow, Colon, Thyroid, Skin, Prostate, B cells, Endothelial, Eye, Spinal cord, Salivary gland, Monocytes

Animal Models for Sinusitis or affiliated genes

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MGI Mouse Phenotypes related to Sinusitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2LTC4S, IL5, IL4, CCL11, CFTR
2MP:00053878.1CCL11, IL4, IL5, IL8, LTC4S, CFTR

Publications for Sinusitis

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Articles related to Sinusitis:

(show top 50)    (show all 1551)
idTitleAuthorsYear
1
Reconstructed bone chip detachment is a risk factor for sinusitis after transsphenoidal surgery. (24375023)
2014
2
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
3
Intranasal steroids for acute sinusitis. (24293353)
2013
4
Acute sphenoid sinusitis leading to contralateral cavernous sinus thrombosis: a case report. (23883649)
2013
5
Quadrupedal head position enhances recovery from chronic maxillary sinusitis. (23731852)
2013
6
Acute sinusitis in adults--reply. (23712408)
2013
7
Comparison of clinical data, CT, and bone histopathology in unilateral chronic maxillary sinusitis. (23112270)
2013
8
Cryptococcal meningitis presenting as sinusitis in a renal transplant recipient. (24034280)
2013
9
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. (22118926)
2012
10
Inverted papilloma with associated carcinoma of the nasal cavity and paranasal sinuses: treatment outcomes. (22035165)
2012
11
Miller Fisher variant of Guillain-BarrAc syndrome masquerading as acute sphenoid sinusitis with orbital apex syndrome. (22447677)
2012
12
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
13
Sinus augmentation surgery after endoscopic sinus surgery for the treatment of chronic maxillary sinusitis: a case report. (21869684)
2011
14
Pott's puffy tumor, intracranial, and orbital complications as the initial presentation of sinusitis in healthy adolescents, a case series. (21380513)
2011
15
Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. (22461817)
2011
16
Microbiology of acute complicated bacterial sinusitis at the University of the Witwatersrand. (20822623)
2010
17
Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. (21154389)
2010
18
Subcutaneous emphysema in a case of infective sinusitis: a case report. (20678214)
2010
19
Incidence and presentation of fungal sinusitis in patient diagnosed with chronic rhinosinusitis. (22319697)
2010
20
Pilot study of budesonide inhalant suspension irrigations for chronic eosinophilic sinusitis. (19910027)
2009
21
Endoscopic frontal sinus septectomy in the treatment of unilateral frontal sinusitis: revisiting an open technique. (19958729)
2009
22
Balloon sinuplasty in acute frontal sinusitis. (19936361)
2009
23
Subdural empyema complicating sinusitis. (18155385)
2008
24
Initial surgical treatment for chronic frontal sinusitis: a pilot study. (17491529)
2007
25
Frequency of recovery of pathogens causing acute maxillary sinusitis in adults before and after introduction of vaccination of children with the 7-valent pneumococcal vaccine. (16772423)
2006
26
The role of bacterial interference in otitis, sinusitis and tonsillitis. (16025067)
2005
27
Analysis of the sinusitis nasal lavage fluid proteome using capillary liquid chromatography interfaced to electrospray ionization-quadrupole time of flight- tandem mass spectrometry. (15174061)
2004
28
First case of Arthrographis kalrae ethmoid sinusitis and ophthalmitis in the People's Republic of China. (15472353)
2004
29
Management of acute maxillary sinusitis in Finnish primary care. Results from the nationwide MIKSTRA study. (15255494)
2004
30
Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis. (11577554)
2002
31
Intracranial complications of frontal sinusitis in children: Pott's puffy tumor revisited. (11549918)
2001
32
Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. (11561799)
2001
33
Experimental myospherulosis of the paranasal sinuses: a histologic rabbit study. (10793918)
2000
34
Lactoferrin and eosinophilic cationic protein in nasal secretions of patients with experimental rhinovirus colds, natural colds, and presumed acute community-acquired bacterial sinusitis. (10921988)
2000
35
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
36
Sinusitis in the common cold. (9768580)
1998
37
Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism. (9674310)
1998
38
IL-4 and IL-13 expression in chronic sinusitis: relationship with cellular infiltrate and effect of topical corticosteroid treatment. (9176799)
1997
39
Antimicrobial treatment of sinusitis. (1771306)
1991
40
Bacteriology of chronic maxillary sinusitis in adults. (2729825)
1989
41
Serological evidence of viral or Mycoplasma pneumoniae infection in acute maxillary sinusitis. (2498094)
1989
42
Sphenoid sinusitis presenting as chronic meningitis. (3699068)
1986
43
Effects of phenylpropanolamine on ostial and nasal patency in patients treated for chronic maxillary sinusitis. (3727982)
1986
44
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
45
Conservative therapy for right frontal sinusitis in a Brahman bull. (6917610)
1982
46
Spontaneous enophthalmos associated with chronic maxillary sinusitis. (7301315)
1981
47
Nursing care study--acute frontal sinusitis with associated osteitis. (281656)
1978
48
Primary dextrocardia with situs inversus, associated with sinusitis and bronchitis in a dog. (4857725)
1974
49
Bacteriological findings in acute maxillary sinusitis. (4405604)
1972
50
OEdema of Conjunctiva from Acute Frontal Sinusitis. (19975137)
1911

Variations for Sinusitis

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Expression for genes affiliated with Sinusitis

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Expression patterns in normal tissues for genes affiliated with Sinusitis

Search GEO for disease gene expression data for Sinusitis.

Pathways for genes affiliated with Sinusitis

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Pathways related to Sinusitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL8, CCL11
29.8IL5, IL4
39.8IL4, IL5
49.8IL4, IL5
59.8IL5, IL4
6
Show member pathways
9.6IL8, CFTR
79.4IL5, IL4, CCL11
8
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.4IL4, IL5, IL8
99.4IL5, IL8, IL4
109.4IL8, IL5, IL4
11
Show member pathways
9.3IL8, CCL11, CFTR
12
Show member pathways
9.2RNASE3, CCL11, IL4, IL5
139.1IL4, IL5, IL8, CCL11
14
Show member pathways
9.1IL5, CCL11, IL8, IL4
15
Show member pathways
9.1CCL11, IL5, IL8, IL4
16
Show member pathways
9.1IL5, IL8, CCL11, IL4
17
Show member pathways
9.1IL8, IL5, IL4, CCL11
18
Show member pathways
8.5CCL11, IL4, IL5, IL8, LTC4S
19
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.1IL8, IL4, CCL11, CFTR, DEFB4A

Compounds for genes affiliated with Sinusitis

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Compounds related to Sinusitis according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1unicap4410.0RNASE3, IL5, CCL11
2sodium cromoglycate449.9RNASE3, CCL11, IL5
3levocetirizine449.8CCL11, IL8, IL4
4epinastine44 1110.7CYP2B6, IL5, IL4
5ketotifen44 1110.7IL5, CCL11, RNASE3
6formoterol44 28 1111.7IL4, IL8, RNASE3
7praziquantel44 1110.6RNASE3, IL5, IL4
8cetirizine44 28 24 1112.6IL8, IL5, RNASE3, CCL11
9salbutamol44 50 28 24 1113.6CCL11, RNASE3, IL8, IL5
10pranlukast44 28 1111.6IL4, IL5, CCL11, RNASE3
11roxithromycin44 28 1111.6IL8, CYP2B6, CCL11, IL5
12azelastine44 1110.5RNASE3, CYP2B6, IL5, IL4
13nedocromil sodium449.5IL5, IL4, RNASE3, IL8
14n-formylmethionyl-leucylphenylalanine449.5CCL11, IL8, RNASE3, IL5
15itraconazole44 1110.5IL5, IL4, CYP2B6
16lte4449.5CCL11, RNASE3, IL5, LTC4S
17allergens449.5RNASE3, IL5, CCL11, IL4
18ltc4449.4LTC4S, RNASE3, CCL11, IL5
19rolipram44 61 2811.4IL8, IL5, IL4, CCL11
20poly(i-c)449.4IL4, IL5, IL8, CCL11
21pgd2449.4RNASE3, LTC4S, CCL11, IL5
22tarc449.4IL8, IL5, IL4, CCL11
23ltd4449.4RNASE3, IL5, LTC4S
24clarithromycin44 1110.4LACTB, IL8, IL5, CCL11
25azithromycin44 1110.3LACTB, CFTR, IL8
26erythromycin44 2 50 1112.2CYP2B6, LACTB, IL8, IL5
27salmeterol44 50 28 1112.2RNASE3, CCL11, IL4, IL5, IL8
28budesonide44 50 1111.2RNASE3, IL5, IL4, CCL11, IL8
29fluticasone propionate44 50 61 1112.2IL4, RNASE3, CCL11, IL5, IL8
30methacholine44 50 1111.2CCL11, RNASE3, IL8, IL4, IL5
31il-12449.1IL8, IL5, IL4
32anti-fungal449.1RNASE3, CYP2B6, DEFB4A, IL5
33herbimycin a44 6110.1IL5, IL8, CCL11, IL4
34n acetylcysteine448.9CFTR, IL4, RNASE3, IL8, CCL11
35indomethacin44 28 61 1111.9CCL11, CFTR, IL4, IL5, CYP2B6
36hbd2448.9IL8, DEFB4A, PI3
37aspirin44 50 28 2411.8LTC4S, IL4, CCL11, RNASE3, CFTR
38leukotriene b444 61 2410.8CYP2B6, RNASE3, CCL11, IL5, IL8, LTC4S
39montelukast44 50 28 1111.7IL5, RNASE3, CCL11, IL4, LTC4S, IL8
40ly294002448.6IL8, PI3, CCL11, IL4, IL5
41rantes448.4DEFB4A, RNASE3, IL5, IL4, CCL11, IL8
42pge2448.2CFTR, IL4, RNASE3, CCL11, LTC4S, IL5
43genistein44 28 61 2 24 1113.1CFTR, DEFB4A, CCL11, IL5, IL8
44sb 20358044 619.0DEFB4A, IL4, PI3, IL8, CCL11, IL5
45cyclosporin a44 28 619.8IL4, IL5, IL8, CCL11, RNASE3, CFTR
46retinoic acid44 248.7RNASE3, CCL11, CYP2B6, CFTR, PI3, DEFB4A
47cysteine447.3LTC4S, IL8, IL5, DEFB4A, IL4, CFTR
48histamine44 28 249.3RNASE3, IL8, LTC4S, IL5, IL4, CCL11
49tyrosine447.2LTC4S, DEFB4A, PI3, CYP2B6, RNASE3, CCL11
50dexamethasone44 50 28 119.5CYP2B6, IL5, LTC4S, IL8, PI3, IL4

GO Terms for genes affiliated with Sinusitis

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Cellular components related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1IL8, IL5, IL4, CCL11
2extracellular regionGO:0055768.1IL8, IL5, CCL11, RNASE3, DEFB4A

Biological processes related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.7IL4, IL5
2response to cytokineGO:0340979.6IL4, CFTR
3inflammatory responseGO:0069549.2CCL11, IL8, IL5
4chemotaxisGO:0069358.6IL8, IL4, DEFB4A, CCL11
5immune responseGO:0069558.3IL5, DEFB4A, CCL11, IL4, IL8

Molecular functions related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8IL8, CCL11

Products for genes affiliated with Sinusitis

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  • Antibodies
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Sources for Sinusitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet