MCID: SNS014
MIFTS: 57

Sinusitis malady

Respiratory diseases category

Summaries for Sinusitis

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Sinusitis means your sinuses are inflamed. the cause can be an infection or another problem. your sinuses are hollow air spaces within the bones surrounding the nose. they produce mucus, which drains into the nose. if your nose is swollen, this can block the sinuses and cause pain. there are several types of sinusitis, including acute, which lasts up to 4 weeks subacute, which lasts 4 to 12 weeks chronic, which lasts more than 12 weeks and can continue for months or even years recurrent, with several attacks within a year acute sinusitis often starts as a cold, which then turns into a bacterial infection. allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. there may also be mucus drainage in the back of the throat, called postnasal drip. your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. you may also need imaging tests. treatments include antibiotics, decongestants, and pain relievers. using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help. nih: national institute of allergy and infectious diseases

MalaCards: Sinusitis is related to rhinitis and meningitis. An important gene associated with Sinusitis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are TSLP Signaling Pathway and Inflammatory Response Pathway. The drugs ciprofloxacin and pseudoephedrine and the compounds unicap and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related mouse phenotypes are respiratory system and immune system.

Wikipedia:66 Sinusitis, also known as rhinosinusitis, is inflammation of the paranasal sinuses. It can be due to... more...

Aliases & Classifications for Sinusitis

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Sources:
11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

sinusitis 11 46 35 63


Related Diseases for Sinusitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Sinusitis family:

Chronic Frontal Sinusitis Acute Frontal Sinusitis
Frontal Sinusitis

Diseases related to Sinusitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 431)
idRelated DiseaseScoreTop Affiliating Genes
1rhinitis30.7RNASE3, CCL11, IL4, IL5, IL8
2meningitis30.7IL8, LACTB
3tonsillitis30.6LACTB
4allergic bronchopulmonary aspergillosis30.6CFTR, IL4, IL5
5otitis media30.5CCL11, RNASE3, LACTB
6bronchitis30.4RNASE3
7common cold30.4RNASE3, CCL11, IL8
8allergic rhinitis30.3RNASE3, CCL11, IL4, IL5, IL8
9bronchiectasis30.3CFTR, RNASE3, IL8
10asthma30.3DEFB4A, RNASE3, CCL11, IL4, IL5, IL8
11cystic fibrosis30.3DEFB4A, PI3, CFTR, LACTB, RNASE3, IL8
12conjunctivitis30.1RNASE3
13eosinophilia30.1RNASE3, CCL11, IL4, IL5, IL8
14prostatitis30.1LACTB
15influenza30.1CFTR, LACTB, CCL11
16bacterial meningitis30.0LACTB, IL8
17pneumonia30.0CCL11, IL5, IL8, LACTB, CFTR, PI3
18leukemia30.0CYP2B6, CFTR, LACTB, RNASE3, CCL11, IL4
19tuberculosis29.9IL4, LACTB, CYP2B6, DEFB4A
20atopy29.8LTC4S, IL5, IL4, CCL11, RNASE3
21melanoma29.8IL8, IL4, CCL11, LACTB, CFTR
22esophagitis29.8IL5, CCL11
23intrinsic asthma29.7RNASE3, IL4, IL5
24urticaria29.7LTC4S, RNASE3
25angioedema29.7RNASE3, IL5, LTC4S
26food allergy29.7RNASE3, CCL11, IL4, IL5
27uveitis29.7IL4, CCL11
28sepsis29.6IL8, LACTB, PI3, DEFB4A
29frontal sinusitis11.0
30chronic maxillary sinusitis10.8
31acute maxillary sinusitis10.8
32sphenoid sinusitis10.8
33acute frontal sinusitis10.7
34chronic frontal sinusitis10.6
35inverted papilloma10.6
36ethmoid sinusitis10.5
37papilloma10.5
38cellulitis10.5
39orbital cellulitis10.5
40aspergillosis10.5
41osteomyelitis10.4
42cavernous sinus thrombosis10.4
43subdural empyema10.4
44acute sphenoidal sinusitis10.4
45cerebritis10.4
46ossifying fibroma10.4
47fibroma10.4
48headache10.4
49chronic ethmoiditis10.3
50rokitansky-aschoff sinuses of the gallbladder10.3

Graphical network of the top 20 diseases related to Sinusitis:



Diseases related to sinusitis

Symptoms for Sinusitis

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Drugs & Therapeutics for Sinusitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Sinusitis

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Anatomical Context for Sinusitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Sinusitis:

34
Bone, Testes, Brain, Tonsil, T cells, Pituitary, Lymph node, Lung, Myeloid, Breast, Bone marrow, Thyroid, Prostate, Endothelial, Colon, Skin, B cells, Monocytes, Salivary gland, Spinal cord

Animal Models for Sinusitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Sinusitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.2LTC4S, IL5, IL4, CCL11, CFTR
2MP:00053878.1CCL11, IL4, IL5, IL8, LTC4S, CFTR

Publications for Sinusitis

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Sources:
53PubMed
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Articles related to Sinusitis:

(show top 50)    (show all 1491)
idTitleAuthorsYear
1
Reconstructed bone chip detachment is a risk factor for sinusitis after transsphenoidal surgery. (24375023)
2014
2
Ossifying fibroma of the nose and paranasal sinuses. (22736440)
2013
3
Intranasal steroids for acute sinusitis. (24293353)
2013
4
Acute sphenoid sinusitis leading to contralateral cavernous sinus thrombosis: a case report. (23883649)
2013
5
Quadrupedal head position enhances recovery from chronic maxillary sinusitis. (23731852)
2013
6
Acute sinusitis in adults--reply. (23712408)
2013
7
Comparison of clinical data, CT, and bone histopathology in unilateral chronic maxillary sinusitis. (23112270)
2013
8
Cryptococcal meningitis presenting as sinusitis in a renal transplant recipient. (24034280)
2013
9
Incidence of maxillary sinusitis and oro-antral fistulae in bisphosphonate-related osteonecrosis of the jaw. (22118926)
2012
10
Inverted papilloma with associated carcinoma of the nasal cavity and paranasal sinuses: treatment outcomes. (22035165)
2012
11
Miller Fisher variant of Guillain-BarrAc syndrome masquerading as acute sphenoid sinusitis with orbital apex syndrome. (22447677)
2012
12
Transforming growth factor beta and platelets in allergic rhinitis and sinusitis. (21967968)
2011
13
Sinus augmentation surgery after endoscopic sinus surgery for the treatment of chronic maxillary sinusitis: a case report. (21869684)
2011
14
Pott's puffy tumor, intracranial, and orbital complications as the initial presentation of sinusitis in healthy adolescents, a case series. (21380513)
2011
15
Oncogenic osteomalacia due to phosphaturic mesenchymal tumor of the craniofacial sinuses. (22461817)
2011
16
Microbiology of acute complicated bacterial sinusitis at the University of the Witwatersrand. (20822623)
2010
17
Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. (21154389)
2010
18
Subcutaneous emphysema in a case of infective sinusitis: a case report. (20678214)
2010
19
Incidence and presentation of fungal sinusitis in patient diagnosed with chronic rhinosinusitis. (22319697)
2010
20
Endoscopic frontal sinus septectomy in the treatment of unilateral frontal sinusitis: revisiting an open technique. (19958729)
2009
21
Balloon sinuplasty in acute frontal sinusitis. (19936361)
2009
22
Subdural empyema complicating sinusitis. (18155385)
2008
23
Initial surgical treatment for chronic frontal sinusitis: a pilot study. (17491529)
2007
24
Frequency of recovery of pathogens causing acute maxillary sinusitis in adults before and after introduction of vaccination of children with the 7-valent pneumococcal vaccine. (16772423)
2006
25
A targeted endoscopic approach to chronic isolated frontal sinusitis. (16399176)
2006
26
The role of bacterial interference in otitis, sinusitis and tonsillitis. (16025067)
2005
27
Analysis of the sinusitis nasal lavage fluid proteome using capillary liquid chromatography interfaced to electrospray ionization-quadrupole time of flight- tandem mass spectrometry. (15174061)
2004
28
First case of Arthrographis kalrae ethmoid sinusitis and ophthalmitis in the People's Republic of China. (15472353)
2004
29
Management of acute maxillary sinusitis in Finnish primary care. Results from the nationwide MIKSTRA study. (15255494)
2004
30
Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis. (11577554)
2002
31
Intracranial complications of frontal sinusitis in children: Pott's puffy tumor revisited. (11549918)
2001
32
Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. (11561799)
2001
33
Experimental myospherulosis of the paranasal sinuses: a histologic rabbit study. (10793918)
2000
34
Lactoferrin and eosinophilic cationic protein in nasal secretions of patients with experimental rhinovirus colds, natural colds, and presumed acute community-acquired bacterial sinusitis. (10921988)
2000
35
Expression of interleukin (IL)-12 (p40) and IL-12 (beta 2) receptors in allergic rhinitis and chronic sinusitis. (10520052)
1999
36
Sinusitis in the common cold. (9768580)
1998
37
Case report: necrotic glossitis and sinusitis in a cow caused apparently by a Fusobacterium necrophorum like microorganism. (9674310)
1998
38
IL-4 and IL-13 expression in chronic sinusitis: relationship with cellular infiltrate and effect of topical corticosteroid treatment. (9176799)
1997
39
Primary-care-based randomised placebo-controlled trial of antibiotic treatment in acute maxillary sinusitis. (9078199)
1997
40
Antimicrobial treatment of sinusitis. (1771306)
1991
41
Bacteriology of chronic maxillary sinusitis in adults. (2729825)
1989
42
Serological evidence of viral or Mycoplasma pneumoniae infection in acute maxillary sinusitis. (2498094)
1989
43
Sphenoid sinusitis presenting as chronic meningitis. (3699068)
1986
44
Effects of phenylpropanolamine on ostial and nasal patency in patients treated for chronic maxillary sinusitis. (3727982)
1986
45
Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses A clinicopathologic study of 20 cases. (6322958)
1984
46
Conservative therapy for right frontal sinusitis in a Brahman bull. (6917610)
1982
47
Spontaneous enophthalmos associated with chronic maxillary sinusitis. (7301315)
1981
48
Nursing care study--acute frontal sinusitis with associated osteitis. (281656)
1978
49
Bacteriological findings in acute maxillary sinusitis. (4405604)
1972
50
OEdema of Conjunctiva from Acute Frontal Sinusitis. (19975137)
1911

Variations for Sinusitis

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Expression for genes affiliated with Sinusitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sinusitis

Search GEO for disease gene expression data for Sinusitis.

Pathways for genes affiliated with Sinusitis

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Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 55R&D Systems, 61Thomson Reuters, 56Reactome, 31KEGG, 13EMD Millipore
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Pathways related to Sinusitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL8, CCL11
29.8IL4, IL5
39.8IL5, IL4
49.8IL4, IL5
59.8IL5, IL4
6
Show member pathways
9.6IL8, CFTR
79.4IL5, IL4, CCL11
8
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.4IL8, IL5, IL4
99.4IL8, IL5, IL4
109.4IL8, IL5, IL4
11
Show member pathways
9.3IL8, CCL11, CFTR
12
Show member pathways
9.2RNASE3, CCL11, IL4, IL5
139.1CCL11, IL4, IL5, IL8
14
Show member pathways
9.1CCL11, IL4, IL5, IL8
15
Show member pathways
9.1CCL11, IL4, IL5, IL8
16
Show member pathways
9.1CCL11, IL4, IL5, IL8
17
Show member pathways
9.1IL8, IL5, IL4, CCL11
18
Show member pathways
8.5CCL11, IL4, IL5, IL8, LTC4S
19
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.1IL8, IL4, CCL11, CFTR, DEFB4A

Compounds for genes affiliated with Sinusitis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Sinusitis according to GeneCards/GeneDecks:

(show top 50)    (show all 136)
idCompoundScoreTop Affiliating Genes
1unicap4610.0RNASE3, IL5, CCL11
2sodium cromoglycate469.9RNASE3, CCL11, IL5
3levocetirizine469.8CCL11, IL8, IL4
4epinastine46 1210.7CYP2B6, IL5, IL4
5ketotifen46 1210.7IL5, CCL11, RNASE3
6formoterol46 30 1211.7IL4, IL8, RNASE3
7praziquantel46 1210.6RNASE3, IL5, IL4
8cetirizine46 30 25 1212.6IL8, IL5, RNASE3, CCL11
9salbutamol46 52 30 25 1213.6CCL11, RNASE3, IL8, IL5
10pranlukast46 30 1211.6IL4, IL5, CCL11, RNASE3
11roxithromycin46 30 1211.6IL8, CYP2B6, CCL11, IL5
12azelastine46 1210.5RNASE3, CYP2B6, IL5, IL4
13nedocromil sodium469.5IL5, IL4, RNASE3, IL8
14n-formylmethionyl-leucylphenylalanine469.5CCL11, IL8, RNASE3, IL5
15itraconazole46 1210.5IL5, IL4, CYP2B6
16lte4469.5CCL11, RNASE3, IL5, LTC4S
17allergens469.5RNASE3, IL5, CCL11, IL4
18ltc4469.4LTC4S, RNASE3, CCL11, IL5
19rolipram46 62 3011.4IL8, IL5, IL4, CCL11
20poly(i-c)469.4IL4, IL5, IL8, CCL11
21pgd2469.4RNASE3, LTC4S, CCL11, IL5
22tarc469.4IL8, IL5, IL4, CCL11
23ltd4469.4RNASE3, IL5, LTC4S
24clarithromycin46 1210.4LACTB, IL8, IL5, CCL11
25azithromycin46 1210.3LACTB, CFTR, IL8
26erythromycin46 3 52 1212.2CYP2B6, LACTB, IL8, IL5
27salmeterol46 52 30 1212.2RNASE3, CCL11, IL4, IL5, IL8
28budesonide46 52 1211.2RNASE3, IL5, IL4, CCL11, IL8
29fluticasone propionate46 52 62 1212.2IL4, RNASE3, CCL11, IL5, IL8
30methacholine46 52 1211.2CCL11, RNASE3, IL8, IL4, IL5
31il-12469.1IL8, IL5, IL4
32anti-fungal469.1RNASE3, CYP2B6, DEFB4A, IL5
33herbimycin a46 6210.1IL5, IL8, CCL11, IL4
34n acetylcysteine468.9CFTR, IL4, RNASE3, IL8, CCL11
35indomethacin46 30 62 1211.9CCL11, CFTR, IL4, IL5, CYP2B6
36hbd2468.9IL8, DEFB4A, PI3
37aspirin46 52 30 2511.8LTC4S, IL4, CCL11, RNASE3, CFTR
38leukotriene b446 62 2510.8CYP2B6, RNASE3, CCL11, IL5, IL8, LTC4S
39montelukast46 52 30 1211.7IL5, RNASE3, CCL11, IL4, LTC4S, IL8
40ly294002468.6IL8, PI3, CCL11, IL4, IL5
41rantes468.4DEFB4A, RNASE3, IL5, IL4, CCL11, IL8
42pge2468.2CFTR, IL4, RNASE3, CCL11, LTC4S, IL5
43genistein46 30 62 3 25 1213.1CFTR, DEFB4A, CCL11, IL5, IL8
44sb 20358046 629.0DEFB4A, IL4, PI3, IL8, CCL11, IL5
45cyclosporin a46 30 629.8IL4, IL5, IL8, CCL11, RNASE3, CFTR
46retinoic acid46 258.7RNASE3, CCL11, CYP2B6, CFTR, PI3, DEFB4A
47cysteine467.3LTC4S, IL8, IL5, DEFB4A, IL4, CFTR
48histamine46 30 259.3RNASE3, IL8, LTC4S, IL5, IL4, CCL11
49tyrosine467.2LTC4S, DEFB4A, PI3, CYP2B6, RNASE3, CCL11
50dexamethasone46 52 30 129.5CYP2B6, IL5, LTC4S, IL8, PI3, IL4

GO Terms for genes affiliated with Sinusitis

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Sources:
17Gene Ontology
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Cellular components related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.1IL8, IL5, IL4, CCL11
2extracellular regionGO:0055768.1IL8, IL5, CCL11, RNASE3, DEFB4A

Biological processes related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.7IL5, IL4
2response to cytokineGO:0340979.6IL4, CFTR
3inflammatory responseGO:0069549.2IL8, IL5, CCL11
4chemotaxisGO:0069358.6DEFB4A, CCL11, IL4, IL8
5immune responseGO:0069558.3IL8, IL5, IL4, CCL11, DEFB4A

Molecular functions related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.8IL8, CCL11

Products for genes affiliated with Sinusitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sinusitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet