MCID: SNS014
MIFTS: 40

Sinusitis malady

Summaries for Sinusitis

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Sinusitis means your sinuses are inflamed. the cause can be an infection or another problem. your sinuses are hollow air spaces within the bones surrounding the nose. they produce mucus, which drains into the nose. if your nose is swollen, this can block the sinuses and cause pain. there are several types of sinusitis, including acute, which lasts up to 4 weeks subacute, which lasts 4 to 12 weeks chronic, which lasts more than 12 weeks and can continue for months or even years recurrent, with several attacks within a year acute sinusitis often starts as a cold, which then turns into a bacterial infection. allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. there may also be mucus drainage in the back of the throat, called postnasal drip. your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. you may also need imaging tests. treatments include antibiotics, decongestants, and pain relievers. using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help. nih: national institute of allergy and infectious diseases

MalaCards: Sinusitis is related to frontal sinusitis and chronic maxillary sinusitis. An important gene associated with Sinusitis is HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4), and among its related pathways are Rho Family GTPases and Allograft rejection. The drugs ciprofloxacin and pseudoephedrine and the compounds arginine and methacholine have been mentioned in the context of this disorder. Affiliated tissues include bone and testes.

Wikipedia:63 Sinusitis or rhinosinusitis is inflammation of the paranasal sinuses. It can be due to infection,... more...

Aliases & Classifications for Sinusitis

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10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS
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Aliases & Descriptions:

sinusitis 10 44 33 60


Related Diseases for Sinusitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Sinusitis family:

Chronic Frontal Sinusitis Acute Frontal Sinusitis
Frontal Sinusitis

Diseases related to Sinusitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 431)
idRelated DiseaseScoreTop Affiliating Genes
1frontal sinusitis31.4TUBE1
2chronic maxillary sinusitis31.2IGLV9-49
3rhinitis30.7CCL11, PRG2, IGHE, RNASE3, IL5, IL8
4osteomyelitis30.5LACTB
5meningitis30.5IL8, LACTB
6allergic bronchopulmonary aspergillosis30.4IL5, IGHE
7asthma30.4CCL11, PRG2, IGHE, MUC5B, RNASE3, IL5
8cystic fibrosis30.4MUC5B, RNASE3, IL8, LACTB
9allergic rhinitis30.3CCL11, PRG2, IGHE, RNASE3, IL5, IL8
10otitis media30.3CCL11, IGHE, MUC5B, LACTB, RNASE3
11common cold30.3IL8, RNASE3, CCL11
12bronchitis30.2RNASE3, MUC5B
13pneumonia30.2CCL11, IL5, IL8, LACTB
14bronchiectasis30.2IGHE, RNASE3, IL8
15eosinophilia30.0CCL11, PRG2, IGHE, RNASE3, IL5, IL8
16hypertension30.0F5
17allergic asthma30.0CCL11, IGHE, RNASE3, IL5, IL8
18sagittal sinus thrombosis29.9F5, SERPINC1
19vasculitis29.9PRG2
20conjunctivitis29.8RNASE3, IGHE
21sarcoidosis29.8CCL11
22food allergy29.6CCL11, IGHE, RNASE3, IL5
23urticaria29.6PRG2, IGHE, RNASE3
24angioedema29.6IGHE, RNASE3, IL5
25myocardial infarction29.6SERPINC1, F5, CCL11
26intrinsic asthma29.6IGHE, RNASE3, IL5
27esophagitis29.6CCL11, PRG2, IL5
28purpura29.6SERPINC1
29uveitis29.6CCL11
30mastocytosis29.6IL5, IGHE
31intracranial thrombosis29.6F5, SERPINC1
32diabetes mellitus29.6SERPINC1
33antithrombin iii deficiency29.6F5, SERPINC1
34obesity29.6CCL11
35cerebral palsy29.6AP4M1
36acute maxillary sinusitis10.8
37sphenoid sinusitis10.8
38acute frontal sinusitis10.7
39ethmoid sinusitis10.6
40chronic frontal sinusitis10.6
41inverted papilloma10.5
42papilloma10.5
43acute sphenoidal sinusitis10.5
44cellulitis10.5
45orbital cellulitis10.5
46aspergillosis10.4
47cavernous sinus thrombosis10.4
48subdural empyema10.4
49chronic ethmoiditis10.4
50ossifying fibroma10.3

Graphical network of the top 20 diseases related to Sinusitis:



Diseases related to sinusitis

Clinical Features for Sinusitis

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Drugs & Therapeutics for Sinusitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Sinusitis

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Anatomical Context for Sinusitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Sinusitis:

32
Bone, Testes

Animal Models for Sinusitis or affiliated genes

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Publications for Sinusitis

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Genetic Variations for Sinusitis

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Expression for genes affiliated with Sinusitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sinusitis

Search GEO for disease gene expression data for Sinusitis.

Pathways for genes affiliated with Sinusitis

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Sinusitis

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Sinusitis according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1arginine4411.8IGHE, F5, MYH6, RNASE3, IL5, SERPINC1
2methacholine44 1112.6IGHE, CCL11, RNASE3, IL5, IL8, PRG2
3vegf4411.6IGHE, RNASE3, IL5, IL8, SERPINC1, CCL11
4histamine44 28 2413.6PRG2, IL8, RNASE3, IL5, IGHE, CCL11
5cetirizine44 28 11 2414.5IL5, RNASE3, IGHE, CCL11, IL8
6montelukast44 49 28 1114.5IL8, IL5, RNASE3, IGHE, CCL11
7budesonide44 49 1113.5IL8, IL5, RNASE3, IGHE, CCL11
8salbutamol44 49 28 11 2415.5IL8, IL5, RNASE3, IGHE, CCL11
9fluticasone propionate44 49 59 1114.5CCL11, IGHE, RNASE3, IL5, IL8
10pgd24411.5IGHE, IL5, PRG2, CCL11, RNASE3
11allergens4411.5PRG2, CCL11, IGHE, RNASE3, IL5
12pge24411.5CCL11, DPEP1, RNASE3, IL5, IL8, SERPINC1
13fmlp4411.4RNASE3, CCL11, PRG2, IL5, IL8
14unicap4411.4IGHE, IL5, RNASE3, CCL11
15sodium cromoglycate4411.4CCL11, IGHE, RNASE3, IL5
16nedocromil sodium4411.4IL8, IGHE, IL5, RNASE3
17heparin44 28 11 2414.4RNASE3, CCL11, PRG2, IL8
18salmeterol44 49 28 1114.4RNASE3, IL8, CCL11, IL5
19ketotifen44 1112.4CCL11, IGHE, RNASE3, IL5
20penicillin4411.4IGHE, IL5, LACTB, F5
21clarithromycin44 1112.4LACTB, IL5, IL8, CCL11
22ltc44411.3RNASE3, PRG2, CCL11, IL5
23lidocaine44 28 1113.3IL5, IGHE, SCN5A, SERPINC1
24tarc4411.3CCL11, IL5, IL8, IGHE
25n-formylmethionyl-leucylphenylalanine4411.3CCL11, IL8, IL5, RNASE3
26retinoic acid44 2412.3IL5, RNASE3, MYH6, IGHE, CCL11, F5
27n acetylcysteine4411.3CCL11, IL8, RNASE3, IGHE, SERPINC1
28imipenem4411.2SERPINC1, LACTB, DPEP1
29beclomethasone dipropionate4411.2RNASE3, IGHE, IL5
30indomethacin44 59 28 1114.2CCL11, IL5, PRG2, IGHE, DPEP1
31anti-histamine4411.2CCL11, RNASE3, IGHE
32lte44411.2IL5, CCL11, RNASE3
33aprotinin44 1112.2SERPINC1, IL8, IGHE, F5
34toluene diisocyanate4411.2IGHE, RNASE3, IL5
35endotoxin4411.2F5, DPEP1, RNASE3
36roxithromycin44 28 1113.2IL5, CCL11, IL8
37loratadine44 11 2413.2RNASE3, IGHE, IL8
38gabexate mesilate4411.1SERPINC1, IL8, F5
39ceftriaxone44 1112.1LACTB, F5, IL5
40pranlukast44 28 1113.1IL5, RNASE3, CCL11
41leukotriene b444 59 2413.1RNASE3, IL5, CCL11, IL8
42praziquantel44 1112.1RNASE3, IGHE, IL5
43protamine4411.1SERPINC1, F5
44sulfamethoxazole44 49 1113.1IGHE, IL5, LACTB
45prednisolone44 28 1113.1IGHE, RNASE3, IL5, CCL11
46azelastine44 1112.0IL5, RNASE3, IGHE
47hydrocortisone44 2 59 1114.0IL8, IGHE, F5, IL5
48meropenem4410.7LACTB, DPEP1
49piperacillin44 1111.6LACTB, RNASE3
50hirudin4410.5SERPINC1, IL8, F5

GO Terms for genes affiliated with Sinusitis

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16Gene Ontology
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Cellular components related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.2SERPINC1, CCL11, F5, PRG2, IGHE, MUC5B
2extracellular spaceGO:00561511.2F5, DPEP1, IL5, IL8, SERPINC1, CCL11

Biological processes related to Sinusitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle contractionGO:00693610.8HCN4, MYH6, GALR2
2immune responseGO:00695510.8IL8, IL5, IGHE, PRG2, CCL11

Products for genes affiliated with Sinusitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Sinusitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet