Aliases & Classifications for Sinusitis

MalaCards integrated aliases for Sinusitis:

Name: Sinusitis 37 28 51 40 59 69

Classifications:



External Ids:

UMLS 69 C0037199

Summaries for Sinusitis

MedlinePlus : 40 Sinusitis means your sinuses are inflamed. The cause can be an infection or another problem. Your sinuses are hollow air spaces within the bones surrounding the nose. They produce mucus, which drains into the nose. If your nose is swollen, this can block the sinuses and cause pain. There are several types of sinusitis, including Acute, which lasts up to 4 weeks Subacute, which lasts 4 to 12 weeks Chronic, which lasts more than 12 weeks and can continue for months or even years Recurrent, with several attacks within a year Acute sinusitis often starts as a cold, which then turns into a bacterial infection. Allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. Symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip. Your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. You may also need imaging tests. Treatments include antibiotics, decongestants, and pain relievers. Using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help. NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : Sinusitis is related to common cold and cystic fibrosis, and has symptoms including equilibration disorder, vertigo/dizziness and sore throat. An important gene associated with Sinusitis is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Augmentin and Avelox I.V. have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are digestive/alimentary and immune system

PubMed Health : 59
About sinusitis: Sinusitis is an inflammation of the paranasal sinuses. The full medical term for sinusitis is "rhinosinusitis" ("rhino-" meaning "nose"), because it affects the mucous membranes lining both the nose and the sinuses.The paranasal sinuses are part of the upper airways, and are connected to the nasal cavity. They are made up of several cavities in the skull found from the forehead down to the teeth of the upper jaw. Depending on where they are, these cavities are known as the frontal sinuses, the sphenoid sinus, the ethmoid cells and the maxillary sinuses. The paranasal sinuses are lined with mucous membranes that have tiny hairs (ciliated epithelium). These mucous membranes produce a secretion that runs down through the nose and throat.

Wikipedia : 72 Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the sinuses resulting... more...

Related Diseases for Sinusitis

Diseases in the Sinusitis family:

Chronic Frontal Sinusitis Frontal Sinusitis
Acute Frontal Sinusitis

Diseases related to Sinusitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 484)
# Related Disease Score Top Affiliating Genes
1 common cold 32.5 CXCL8 IL5 RNASE3
2 cystic fibrosis 31.0 CFTR CXCL8 DEFB4A RNASE3
3 chronic conjunctivitis 30.4 IL5 RNASE3
4 allergic bronchopulmonary aspergillosis 30.3 CFTR IL5
5 cellulitis 30.1 DEFB4A IL5 RNASE3
6 allergic rhinitis 29.7 CXCL8 IL4R IL5 RNASE3
7 respiratory system disease 29.7 CFTR CXCL8 CYSLTR1 IL5 RNASE3
8 intrinsic asthma 29.6 IL5 RNASE3
9 ige responsiveness, atopic 29.6 IL4R IL5 RNASE3
10 status asthmaticus 29.6 CXCL8 IL5 RNASE3
11 conjunctivitis 29.5 CXCL8 IL5 RNASE3
12 milk allergy 29.5 IL5 RNASE3
13 churg-strauss syndrome 29.5 IL5 RNASE3
14 bronchitis 29.3 CFTR CXCL8 IL5 RNASE3
15 allergic hypersensitivity disease 29.2 IL4R IL5 RNASE3
16 rhinitis 29.2 CXCL8 CYSLTR1 IL4R IL5 RNASE3
17 food allergy 28.8 IL5 RNASE3
18 asthma 27.8 CFTR CXCL8 CYSLTR1 IL4R IL5 LTC4S
19 maxillary sinusitis 12.4
20 sphenoid sinusitis 12.4
21 frontal sinusitis 12.4
22 ethmoid sinusitis 12.4
23 chronic maxillary sinusitis 12.3
24 acute maxillary sinusitis 12.3
25 acute frontal sinusitis 12.3
26 chronic frontal sinusitis 12.3
27 chronic sphenoidal sinusitis 12.3
28 acute sphenoidal sinusitis 12.3
29 rokitansky-aschoff sinuses of the gallbladder 12.0
30 squamous cell carcinoma of the nasal cavity and paranasal sinuses 12.0
31 microcornea, glaucoma, and absent frontal sinuses 11.9
32 chronic ethmoiditis 11.9
33 acute ethmoiditis 11.7
34 kartagener syndrome 11.7
35 sinonasal undifferentiated carcinoma 11.7
36 young syndrome 11.5
37 inverted papilloma 11.3
38 primary ciliary dyskinesia 11.2
39 wegener granulomatosis 11.2
40 yellow nail syndrome 11.2
41 phaeohyphomycosis 11.2
42 ciliary dyskinesia, primary, 1 11.1
43 paranasal sinus disease 11.1
44 orbital cellulitis 11.1
45 aspergillosis 11.1
46 cavernous sinus thrombosis 11.1
47 nasopharyngitis 11.0
48 fibrous dysplasia 11.0
49 pharyngitis 11.0
50 van der woude syndrome 1 11.0

Graphical network of the top 20 diseases related to Sinusitis:



Diseases related to Sinusitis

Symptoms & Phenotypes for Sinusitis

UMLS symptoms related to Sinusitis:


equilibration disorder, vertigo/dizziness, sore throat, sinus congestion, tremor, tinnitus, snoring, pruritus, headache, halitosis, fever, coughing, angina pectoris

MGI Mouse Phenotypes related to Sinusitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 BTK CFTR IL12RB2 IL4R IL5
2 immune system MP:0005387 9.5 BTK CFTR CYSLTR1 IL12RB2 IL4R IL5
3 respiratory system MP:0005388 9.02 CFTR CYSLTR1 IL4R IL5 LTC4S

Drugs & Therapeutics for Sinusitis

PubMedHealth treatment related to Sinusitis: 59

Steroidal or decongestant nasal sprays may relieve discomfort in patients with sinusitis. Nasal irrigation or inhalation may also help, and antibiotics may be an option in some cases.In case of chronic inflammation, one common treatment is surgery to expand narrowed paranasal sinus passageways. This is an option if steroid sprays and other treatments do not provide enough relief.

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Augmentin 17 AMOXICILLIN; CLAVULANATE POTASSIUM SmithKline Beecham February 1996
2
Avelox I.V. 17 MOXIFLOXACIN HYDROCHLORIDE Bayer November 2001
3
Biaxin XL 17 CLARITHROMYCIN Abbott Laboratories March 2000
4
Cipro 17 CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE Bayer June 1997
5
Tequin 17 Bristol-Myers Squibb December, 1999

Drugs for Sinusitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 300)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 26787-78-0 33613 2171
2
Montelukast Approved Phase 4 158966-92-8 5281040
3
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
6
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
7
Cefditoren Approved, Investigational Phase 4 104145-95-1, 117467-28-4 9870843 9571074
8
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
9
Epinephrine Approved, Vet_approved Phase 4,Phase 3 51-43-4 5816
10 Racepinephrine Approved Phase 4,Phase 3 329-65-7
11
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
12
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
13
Moxifloxacin Approved, Investigational Phase 4,Phase 3 151096-09-2, 354812-41-2 152946
14
Norgestimate Approved, Investigational Phase 4,Phase 3 35189-28-7 6540478
15
Omalizumab Approved, Investigational Phase 4,Phase 3,Phase 2 242138-07-4
16
Cefdinir Approved Phase 4 91832-40-5 6915944
17
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
18
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
19
Telithromycin Approved Phase 4,Phase 3 191114-48-4 0 5462516
20
Azithromycin Approved Phase 4,Phase 3,Phase 2 83905-01-5 53477736 447043 55185
21
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
22
Dextromethorphan Approved Phase 4 125-71-3 5362449 5360696
23
Ephedrine Approved Phase 4,Phase 2 299-42-3 9294
24
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
25
Pseudoephedrine Approved Phase 4,Phase 2 90-82-4 7028
26
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
27
Budesonide Approved Phase 4,Phase 2,Phase 3,Phase 1 51333-22-3 5281004 63006
28
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
29
Thrombin Approved, Investigational Phase 4
30
Cocaine Approved, Illicit Phase 4 50-36-2 446220 5760
31
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
32
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
33
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
34
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
35
Almotriptan Approved, Investigational Phase 4 154323-57-6, 181183-52-8 123606
36
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
37
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
38
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
39
Etanercept Approved, Investigational Phase 4 185243-69-0
40
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
41
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
42
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
43
Cefuroxime Approved Phase 4,Phase 2 55268-75-2 5479529 5361202
44
Oseltamivir Approved Phase 4,Phase 3 196618-13-0, 204255-11-8 65028
45
Cefazolin Approved Phase 4 25953-19-9 33255 656510
46
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
47
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
48
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
49
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
50
Citalopram Approved Phase 4 59729-33-8 2771

Interventional clinical trials:

(show top 50) (show all 321)

# Name Status NCT ID Phase Drugs
1 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
2 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
3 Remifentanil and Controlled Hypotension for Functional Endoscopic Sinus Surgery: Comparison With Tramadol and Metoprolol Unknown status NCT02484859 Phase 4 Remifentanil;Tramadol;Metoprolol
4 Study of Cefditoren Pivoxil in Treatment of Childhood With Acute Rhinosinusitis Unknown status NCT01553006 Phase 4 cefditoren pivoxil
5 Sinuclean's Treatment Of Sinusitis' Symptoms Completed NCT00747747 Phase 4
6 Efficacy and Safety of Sinusitis Hevert SL Tablets Compared to Placebo in Adult Patients With Acute, Uncomplicated Rhinosinusitis Completed NCT02296814 Phase 4 Sinusitis Hevert SL Tablet;Placebo for Sinusitis Hevert SL Tablet
7 Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate Completed NCT02340000 Phase 4 standard dose amoxicillin/clavulanate;high dose amoxicillin/clavulanate
8 Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
9 Xolair in Patients With Chronic Sinusitis Completed NCT00117611 Phase 4 Anti-IgE antibody omalizumab or placebo
10 Study of the Safety and Efficacy of Cefdinir and Levofloxacin for the Treatment of Subjects With Acute Bacterial Sinusitis Completed NCT00645073 Phase 4 cefdinir (Omnicef);levofloxacin
11 Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life Completed NCT00147914 Phase 4 Cefdinir (drug);amoxicillin/clavulanate
12 CHOOSE : Telithromycin, Acute Bacterial Sinusitis Completed NCT00174694 Phase 4 Telithromycin
13 Zmax Compared to Augmentin in Sinusitis Completed NCT00367120 Phase 4 Azithromycin Extended Release;Amoxicillin/Clavulanate
14 Treatment of Acute Sinusitis Completed NCT00377403 Phase 4 Acetaminophen;Amoxicillin;Dextromethorphan hydrobromide with guaifenesin;Guaifenesin;Pseudoephedrine Sustained Action;Saline spray (0.65%)
15 Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis Completed NCT01825408 Phase 4 Doxycycline;Azithromycin;Augmentin
16 Saline Irrigation After Surgery in Patients With Chronic Sinusitis Completed NCT01575223 Phase 4
17 The Optimal Head Position for Distributing Topical Nasal Medication Using the Mucosal Atomization Device Completed NCT02079792 Phase 4
18 Medicated Punctured-Glove-Finger Spacer Study Completed NCT01420471 Phase 4 Triamcinolone
19 Study of Asthma and Nasal Steroids Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
20 Hemostatic Matrix in Endoscopic Sinus Surgery Completed NCT00242437 Phase 4
21 The PIO II Study of In-office Placement of a Steroid-eluting Sinus Implant Completed NCT02668302 Phase 4
22 Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery Completed NCT01706952 Phase 4 Cocaine;Adrenaline
23 Randomized Controlled Trial to Evaluate of Dexmedetomidine for the Effect on Operative Visibility in Patients Undergoing Endoscopic Sinus Surgery Completed NCT01569048 Phase 4 Propofol and dexmedetomidine;propofol and remifentanil
24 Study to Evaluate Safety and Effectiveness of AdvaCoat Sinus Gel Completed NCT00554190 Phase 4
25 Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers Completed NCT00208065 Phase 4 almotriptan or pseudoephedrine
26 Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis Completed NCT00396162 Phase 4 probiotic containing L.rhamnosus R0011 strain
27 The Effect of Packing in Post Operative Management of FESS Completed NCT00793117 Phase 4
28 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
29 The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis Completed NCT02696850 Phase 4 Budesonide;Saline alone
30 Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid Disorders Completed NCT00132418 Phase 4 Enbrel;Placebo
31 Telithromycin in Respiratory Tract Infections Completed NCT00261105 Phase 4 telithromycin
32 Proteomic Profiling for Influenza Completed NCT00133588 Phase 4
33 Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy Completed NCT02307825 Phase 4 Azithromycin;Placebo
34 Systemic Methylprednisolone in Chronic Rhinosinusitis Completed NCT01205984 Phase 4 methylprednisolone
35 Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis Completed NCT03086070 Phase 4 Omeprazole 20mg;Placebo oral capsule
36 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
37 The Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis and Recurrent Sinusitis Recruiting NCT02582099 Phase 4 Gentamicin nasal irrigation;Normal saline nasal irrigation
38 Response of the Airway in Sinusitis and Asthma Recruiting NCT03011632 Phase 4 Mometasone Nasal;placebo mometasone
39 Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions Recruiting NCT03014687 Phase 4 Placebo;Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole
40 Systemic Corticosteroids in the Perioperative Management of Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Recruiting NCT02119273 Phase 4 Prednisone;Placebo
41 Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study Active, not recruiting NCT00841802 Phase 4 Prednisone
42 Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial Active, not recruiting NCT01919411 Phase 4 Amoxicillin-Potassium Clavulanate;Placebo
43 Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate Not yet recruiting NCT03431337 Phase 4 Amoxicillin 875 mg
44 Use of Perioperative Antibiotics in Endoscopic Sinus Surgery Not yet recruiting NCT03369717 Phase 4 Amoxi Clavulanate
45 Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis Terminated NCT00245440 Phase 4 Azithromycin;Telithromycin
46 Sinusitis and Facial Pain Disorders Anti-Depression Trial Terminated NCT00754793 Phase 4 escitalopram;placebo
47 Study of the Use of LUMA Lightwire Terminated NCT00705237 Phase 4
48 Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitis Terminated NCT00493038 Phase 4 Moxifloxacin (Avelox, BAY12-8039);Amoxicillin/Clavulanate
49 Canadian Health Economics, Outcome, and Effectiveness Comparison of Treatment in Patients With Chronic Rhinosinusitis Terminated NCT01455948 Phase 4
50 Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Terminated NCT01676415 Phase 4 Prednisone;Topical mometasone

Search NIH Clinical Center for Sinusitis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Sinusitis

Genetic tests related to Sinusitis:

# Genetic test Affiliating Genes
1 Sinusitis 28

Anatomical Context for Sinusitis

MalaCards organs/tissues related to Sinusitis:

38
Bone, Testes, Skin, Brain, Tonsil, Pituitary, Lymph Node

Publications for Sinusitis

Articles related to Sinusitis:

(show top 50) (show all 1789)
# Title Authors Year
1
Ophthalmic Manifestations of Allergic Fungal Sinusitis. ( 29384825 )
2018
2
Brain abscess in a patient with chronic sinusitis. ( 29321201 )
2018
3
NICE: reduce antibiotic prescribing for acute sinusitis. ( 29288146 )
2018
4
Complicated Fusobacterium Sinusitis: A Case Report. ( 29389826 )
2018
5
Neurological Complications of Acute and Chronic Sinusitis. ( 29404826 )
2018
6
Early life risk factors for chronic sinusitis: a longitudinal birth cohort study. ( 29355680 )
2018
7
Orbital granulomatosis with polyangiitis masquerading as invasive fungal sinusitis. ( 29303390 )
2018
8
Small cell neuroendocrine carcinoma of nose and paranasal sinuses: The Shaukat Khanum Memorial Cancer Hospital experience and review of literature. ( 29371736 )
2018
9
Incidence of Sinusitis Associated With Endotracheal and Nasogastric Tubes: NIS Database. ( 29292272 )
2018
10
Clinical implications of taste thresholds in patients with odontogenic maxillary sinusitis. ( 29174862 )
2018
11
A phase 3 trial of mometasone furoate sinus implants for chronic sinusitis with recurrent nasal polyps. ( 29350840 )
2018
12
Failure of a Best Practice Alert to Reduce Antibiotic Prescribing Rates for Acute Sinusitis Across an Integrated Health System in the Midwest. ( 29384025 )
2018
13
Focus on the Involvement of the Nose and Paranasal Sinuses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Nasal Cytology Reveals Infiltration of Eosinophils as a Very Common Feature. ( 29393242 )
2018
14
Preclinical therapeutic efficacy of the ciprofloxacin-eluting sinus stent for Pseudomonas aeruginosa sinusitis. ( 29334430 )
2018
15
Carotid dissection mimicking sinusitis. ( 29369929 )
2018
16
Intracranial Complications of Sinusitis. ( 29263014 )
2017
17
Allergic fungal sinusitis caused by Schizophyllum commune. ( 29204581 )
2017
18
Novel approach to the maxillary sinusitis after sinus graft. ( 28695114 )
2017
19
Effect of Shin'iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation. ( 28808474 )
2017
20
Maxillary sinuses and midface in patients with cleidocranial dysostosis. ( 28889021 )
2017
21
A Case of Streptococcus anginosus Brain Abscess Caused by Contiguous Spread from Sinusitis in an Immunocompetent Patient. ( 29218260 )
2017
22
Sinusitis, Barosinusitis ( 29261875 )
2017
23
Failure patterns and prognostic factors of patients with primary mucosal melanoma of the nasal cavity and paranasal sinuses. ( 28767022 )
2017
24
Sinusitis, Chronic ( 28722963 )
2017
25
Reply to the letter "Nasal nitric oxide as biomarker in the evaluation and management of chronic rhino-sinusitis with nasal polyposis". ( 28866810 )
2017
26
Nasal Septal Deviation and Concha Bullosa - Do They Have an Impact on Maxillary Sinus Volumes and Prevalence of Maxillary Sinusitis? ( 28348652 )
2017
27
Distinct histopathologic features of radiation-induced chronic sinusitis. ( 28736997 )
2017
28
Minimally invasive removal of nonmobile zygomatic dental implants affected by peri-implantitis and chronic sinusitis. ( 28873016 )
2017
29
Role of Sinonasal Anatomic Variations in the Development of Maxillary Sinusitis: A Cone Beam CT Analysis. ( 28839485 )
2017
30
Role of anatomic variations of paranasal sinuses on the prevalence of sinusitis: Computed tomography findings of 350 patients. ( 29303136 )
2017
31
Subdural empyema as a complication of odontogenic maxillary sinusitis. ( 28843931 )
2017
32
The Role of Periostin in the Occurrence and Progression of Eosinophilic Chronic Sinusitis with Nasal Polyps. ( 28842563 )
2017
33
Safe treatment of ethmoid sinusitis utilizing minimally invasive ethmoid punch sinusotomy in chronic rhinosinusitis without polyposis patients. ( 28194802 )
2017
34
Immunoglobulin G4 sinusitis in association with aspirin-exacerbated respiratory disease. ( 28859705 )
2017
35
Use of computer-assisted design and manufacturing to localize dural venous sinuses during reconstructive surgery for craniosynostosis. ( 28921242 )
2017
36
Diagnosis and First-Line Treatment of Chronic Sinusitis. ( 29260210 )
2017
37
Ocular cranial nerve palsies secondary to sphenoid sinusitis. ( 29204579 )
2017
38
Unusual case of odontogenic maxillary sinusitis. ( 28747419 )
2017
39
Clinical efficacy of main radiological diagnostic methods for odontogenic maxillary sinusitis. ( 28733779 )
2017
40
Interhemispheric and Infratentorial Subdural Empyema with Preseptal Cellulitis as Complications of Sinusitis: A Case Report. ( 29131135 )
2017
41
Imaging of complicated frontal sinusitis. ( 28690724 )
2017
42
Fluoroquinolones for Sinusitis Should Be Used As a Last Resort. ( 28671427 )
2017
43
A review of eight cases of cavernous sinus thrombosis secondary to sphenoid sinusitis, including a12-year-old girl at the present department. ( 28535728 )
2017
44
Sinusitis ( 29262090 )
2017
45
Delayed Diagnosis of a Nasal Type Lymphoma Misdiagnosed as Persistent Sinusitis. ( 28061034 )
2017
46
Odontogenic sinusitis: a comprehensive review. ( 28877613 )
2017
47
Adverse Events in Endoscopic Sinus Surgery for Infectious Orbital Complications of Sinusitis: 30-Day NSQIP Pediatric Outcomes. ( 28675096 )
2017
48
Conservative management of an atypical intra-sinusal ossifying fibroma associated to an aneurysmal bone cyst. ( 29074442 )
2017
49
When Maxillary Sinusitis Does Not Heal: Findings on CBCT Scans of the Sinuses With a Particular Focus on the Occurrence of Odontogenic Causes of Maxillary Sinusitis. ( 29299521 )
2017
50
Distribution of CGRP and TRPV2 in Human Paranasal Sinuses. ( 27553072 )
2017

Variations for Sinusitis

Expression for Sinusitis

LifeMap Discovery
Genes differentially expressed in tissues of Sinusitis patients vs. healthy controls: 35 (show all 38)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 FDCSP follicular dendritic cell secreted protein Nose + 5.87 0.000
2 MUC7 mucin 7, secreted Nose + 5.43 0.001
3 PIP prolactin-induced protein Nose + 5.28 0.000
4 STATH statherin Nose + 5.17 0.000
5 KRT14 keratin 14, type I Nose + 4.90 0.000
6 CRISP3 cysteine-rich secretory protein 3 Nose + 4.46 0.007
7 C6orf58 chromosome 6 open reading frame 58 Nose + 4.30 0.002
8 BPIFB2 BPI fold containing family B, member 2 Nose + 4.26 0.002
9 IGHM immunoglobulin heavy constant mu Nose + 4.22 0.000
10 ZG16B zymogen granule protein 16B Nose + 3.91 0.000
11 LOC285628 MIR146A host gene Nose + 3.85 0.000
12 CXCL13 chemokine (C-X-C motif) ligand 13 Nose + 3.84 0.001
13 AZGP1 alpha-2-glycoprotein 1, zinc-binding Nose + 3.78 0.001
14 SEC14L3 SEC14-like lipid binding 3 Nose - 3.72 0.000
15 TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) Nose + 3.70 0.000
16 DSG3 desmoglein 3 Nose + 3.65 0.000
17 DMBT1 deleted in malignant brain tumors 1 Nose + 3.65 0.003
18 SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) Nose - 3.61 0.000
19 GREM2 gremlin 2, DAN family BMP antagonist Nose - 3.60 0.002
20 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Nose + 3.55 0.001
21 PRB3 proline-rich protein BstNI subfamily 3 Nose + 3.55 0.001
22 LTF lactotransferrin Nose + 3.49 0.008
23 FLJ26850 FLJ26850 protein Nose - 3.49 0.000
24 NCAPG non-SMC condensin I complex, subunit G Nose + 3.48 0.000
25 DUOX2 dual oxidase 2 Nose + 3.43 0.007
26 MUC5B mucin 5B, oligomeric mucus/gel-forming Nose + 3.41 0.000
27 LPO lactoperoxidase Nose + 3.31 0.003
28 C15orf48 chromosome 15 open reading frame 48 Nose + 3.29 0.001
29 STK33 serine/threonine kinase 33 Nose - 3.28 0.008
30 CXCL5 chemokine (C-X-C motif) ligand 5 Nose + 3.20 0.001
31 CXorf57 chromosome X open reading frame 57 Nose - 3.16 0.002
32 ODAM odontogenic, ameloblast asssociated Nose + 3.12 0.007
33 IDO1 indoleamine 2,3-dioxygenase 1 Nose + 3.11 0.011
34 TF transferrin Nose + 3.11 0.000
35 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) Nose + 3.11 0.003
36 PRB4 proline-rich protein BstNI subfamily 4 Nose + 3.09 0.005
37 LRP1B low density lipoprotein receptor-related protein 1B Nose - 3.06 0.003
38 CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 Nose - 3.04 0.001
Search GEO for disease gene expression data for Sinusitis.

Pathways for Sinusitis

Pathways related to Sinusitis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 BTK CXCL8 IL12RB2 IL4R IL5 LTC4S
2
Show member pathways
13.05 BTK CXCL8 IL12RB2 IL4R IL5
3
Show member pathways
12.94 BTK CXCL8 IL12RB2 IL4R IL5
4 12.39 CXCL8 IL12RB2 IL4R IL5
5
Show member pathways
11.96 IL12RB2 IL4R IL5
6
Show member pathways
11.72 CFTR CXCL8 DEFB4A
7
Show member pathways
11.59 CFTR CXCL8 DEFB4A IL5
8 11.01 IL4R IL5
9 10.86 BTK CXCL8 IL5
10 10.46 IL12RB2 IL4R IL5
11 10.34 IL4R IL5
12 10.06 CYSLTR1 LTC4S

GO Terms for Sinusitis

Biological processes related to Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.56 CXCL8 DEFB4A IL4R IL5
2 peptidyl-tyrosine phosphorylation GO:0018108 9.5 BTK IL12RB2 IL5
3 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.37 DEFB4A RNASE3
4 chemotaxis GO:0006935 9.33 CXCL8 CYSLTR1 DEFB4A
5 cytokine-mediated signaling pathway GO:0019221 9.13 IL12RB2 IL4R IL5
6 defense response GO:0006952 8.8 CXCL8 CYSLTR1 DEFB4A

Molecular functions related to Sinusitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.62 IL12RB2 IL4R

Sources for Sinusitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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