MCID: SJG001
MIFTS: 52

Sjogren's Syndrome malady

Summaries for Sjogren's Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Sjogren's syndrome is a disease that causes dryness in your mouth and eyes. it can also lead to dryness in other places that need moisture, such as your nose, throat and skin. most people who get sjogren's syndrome are older than 40. nine of 10 are women. sjogren's syndrome is sometimes linked to rheumatic problems such as rheumatoid arthritis. sjogren's syndrome is an autoimmune disease. if you have an autoimmune disease, your immune system, which is supposed to fight disease, mistakenly attacks parts of your own body. in sjogren's syndrome, your immune system attacks the glands that make tears and saliva. it may also affect your joints, lungs, kidneys, blood vessels, digestive organs and nerves. the main symptoms are: dry eyes dry mouth treatment focuses on relieving symptoms. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Sjogren's Syndrome, also known as sicca syndrome, is related to uveitis and erythema multiforme. An important gene associated with Sjogren's Syndrome is TRIM21 (tripartite motif containing 21). The drug linolenic acid and the compounds glutamate and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and skin.

Disease Ontology:8 An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.

Genetics Home Reference:21 Sjögren syndrome is a disorder whose main features are dry eyes and a dry mouth. The condition typically develops gradually beginning in middle adulthood, but can occur at any age.

NIH Rare Diseases:42 Sjögren syndrome is an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis. the hallmark symptoms of the disorder are dry mouth and dry eyes. in addition, sjogren syndrome may cause skin, nose, and vaginal dryness, and may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain. treatment is symptomatic and supportive and may include moisture replacement therapies, nonsteroidal anti-inflammatory drugs and, in severe cases, corticosteroids or immunosuppressive drugs. last updated: 5/2/2012

NINDS:43 Sj

Wikipedia:63 Sjögren\'s syndrome (pronounced /ˈʃoʊɡrɨn/ SHOH-grin or /ˈʃʌrɡrɨn/ SHUR-grin in... more...

Description from OMIM:46 270150

Aliases & Classifications for Sjogren's Syndrome

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21Genetics Home Reference, 8Disease Ontology, 33MedlinePlus, 60UMLS, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH, 46OMIM, 27ICD9CM
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Aliases & Descriptions:

sjogren's syndrome 8 21 33 60
sicca syndrome 8 42 21 60
sjogren-gougerot syndrome 42 21
sjogrens syndrome 10 44
keratoconjunctivitis sicca-xerostomia 21
secreto-inhibitor-xerodermostenosis 21
dacryosialoadenopathia atrophicans 21
gougerot-houwer-sjogren syndrome 21
keratoconjunctivitis sicca 21
gougerot-sjogren syndrome 21
sjögren's syndrome 43
sjögren syndrome 21
sjogren syndrome 42
xerodermosteosis 8


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Disease Ontology8 DOID:12894
NCIt39 C70647
MeSH34 D012859
OMIM46 270150
ICD9CM27 710.2

Related Diseases for Sjogren's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Sjogren's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.4RNPC3
2erythema multiforme30.4HSPG2
3lupus erythematosus30.1APOH, CD79A, TRIM21, TROVE2
4keratoconjunctivitis sicca30.1LTF, HSPG2
5myopathy30.1SIL1
6systemic lupus erythematosus30.1TNFSF13B
7rheumatoid arthritis29.9HSPG2, TRIM21, LTF, RNPC3, CD79A, SPTAN1
8vasculitis29.9TRIM21, APOH, CD79A, TNFSF13B, LTF
9systemic scleroderma29.9RNPC3, APOH, TNFSF13B, HSPG2, SSB
10connective tissue disease29.9APOH, RNPC3, HSPG2, LTF
11primary biliary cirrhosis29.9RNPC3, HSPG2, LTF, CD79A
12mixed connective tissue disease29.9HSPG2, RNPC3, APOH
13dry eye syndrome29.9HSPG2, LTF
14sialadenitis29.9HSPG2
15hepatitis c29.9RNPC3, HSPG2
16purpura29.9HSPG2, CD79A
17hepatitis29.9HSPG2
18arthritis29.9LTF
19marinesco-sjögren syndrome10.6
20corneal ulcer10.4
21graft versus host disease10.3
22corneal disease10.3
23rosacea10.3
24achalasia10.3
25dacryoadenitis10.3
26ectropion10.3
27esophagitis10.3
28keratoconus10.3
29sarcoidosis10.3
30cataract10.2
31bone fracture10.1
32cutaneous lupus erythematosus10.1
33ocular albinism10.1
34acute dacryocystitis10.1
35juvenile rheumatoid arthritis10.1
36chromosomal disease10.1
37collagen disease10.1
38conjunctivitis10.1
39dacryocystitis10.1
40diabetes mellitus10.1
41diabetic retinopathy10.1
42hypothyroidism10.1
43keratitis10.1
44lagophthalmos10.1
45lens disease10.1
46leprosy10.1
47otitis media10.1
48peritonitis10.1
49pleurisy10.1
50pneumonia10.1

Graphical network of the top 20 diseases related to Sjogren's Syndrome:



Diseases related to sjogren's syndrome

Clinical Features for Sjogren's Syndrome

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46OMIM
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Clinical features from OMIM:

270150

Drugs & Therapeutics for Sjogren's Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sjogren's Syndrome

Drug clinical trials:

Search ClinicalTrials for Sjogren's Syndrome

Search NIH Clinical Center for Sjogren's Syndrome

Search CenterWatch for Sjogren's Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Sjogren's Syndrome

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Anatomical Context for Sjogren's Syndrome

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32MalaCards
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MalaCards organs/tissues related to Sjogren's Syndrome:

32
Eye, Lung, Skin, Kidney, Salivary gland, Liver, Pancreas, Brain, T cells, B cells, Thyroid, Bone, Testes, Monocytes, Bone marrow, Endothelial

Animal Models for Sjogren's Syndrome or affiliated genes

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Publications for Sjogren's Syndrome

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50PubMed
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Articles related to Sjogren's Syndrome:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Limited utility of current MRI criteria for distinguishing multiple sclerosis from common mimickers: primary and secondary CNS vasculitis, lupus and Sjogren's syndrome. (23736535)
2014
2
EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) is sensitive to show efficacy of rituximab treatment in a randomised controlled trial. (23940214)
2014
3
Absence of somatic MYD88 L265P mutations in patients with primary Sjogren's syndrome. (24153350)
2014
4
The impact of primary Sjogren's syndrome on pregnancy outcome: our series and review of the literature. (24044939)
2014
5
High prevalence of autoimmune thyroid disease in subjects with sicca symptoms without Sjogren's syndrome. (23382358)
2013
6
The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome. (24080911)
2013
7
Effects of total glucosides of paeony for delaying onset of Sjogren's syndrome: an animal study. (23333492)
2013
8
Autoantibodies and Sjogren's Syndrome in multiple sclerosis, a reappraisal. (23776474)
2013
9
Anti-SSA Ro52/Ro60 antibody testing by immunodot could help the diagnosis of Sjogren's syndrome in the absence of anti-SSA/SSB antibodies by ELISA. (24026249)
2013
10
CX3CL1 and CX3CR1 expression in tertiary lymphoid structures in salivary gland infiltrates: fractalkine contribution to lymphoid neogenesis in Sjogren's syndrome. (24324211)
2013
11
Different stages of primary Sjogren's syndrome involving lymphotoxin and type 1 IFN. (23772034)
2013
12
Response to: the interaction of Sjogren's syndrome, gastroesophageal reflux and sleep by Tufik et al. (23218537)
2013
13
Type I interferon receptor deficiency prevents murine Sjogren's syndrome. (23533183)
2013
14
Primary Sjogren's syndrome presenting as acute cerebellitis. (24055210)
2013
15
Assessment of blood clot formation and platelet receptor function ex vivo in patients with primary Sjogren's syndrome. (23793707)
2013
16
Prevalence and predictors of Sjogren's syndrome in a prospective cohort of patients with aqueous-deficient dry eye. (23001257)
2012
17
Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjogren's syndrome. (21558290)
2012
18
Ultrasound features of lacrimal gland in Sjogren's syndrome: case report. (23431740)
2012
19
Physical activity and physical activity cognitions are potential factors maintaining fatigue in patients with primary Sjogren's syndrome. (22121127)
2012
20
The expression of APRIL in Sjogren's syndrome: aberrant expression of APRIL in the salivary gland. (22562936)
2012
21
Low copy number of the Fc-I^ receptor 3B gene FCGR3B is a risk factor for primary Sjogren's syndrome. (22942264)
2012
22
Clinical applicability of the EULAR Sjogren's syndrome disease activity index: a cumulative ESSDAI score adds in describing disease severity. (22219139)
2012
23
Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome. (22562982)
2012
24
United Kingdom Primary Sjogren's Syndrome Registry--a united effort to tackle an orphan rheumatic disease. (20693261)
2011
25
Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome. (21450750)
2011
26
Expression of proteasome immunosubunit in labial glands of patients with primary Sjogren's syndrome. (21529441)
2011
27
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. (20007286)
2010
28
Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome. (19833746)
2009
29
Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren's syndrome. (19584730)
2009
30
Sensitive and robust luminescent profiling of anti-La and other autoantibodies in Sjogren's syndrome. (19657778)
2009
31
Fibulin-6 expression and anoikis in human salivary gland epithelial cells: implications in Sjogren's syndrome. (19190085)
2009
32
Effects of oral consumption of the green tea polyphenol EGCG in a murine model for human Sjogren's syndrome, an autoimmune disease. (18809413)
2008
33
The role of interleukin-10 promoter polymorphisms in primary Sjogren's syndrome. (18612930)
2008
34
Anti-beta2-glycoprotein I in Sjogren's syndrome is associated with parkinsonism. (17057945)
2007
35
Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis. (17587445)
2007
36
Recurrent aseptic meningitis: a new CSF complication of Sjogren's syndrome. (17417743)
2007
37
Th2 cytokine genotypes are associated with a milder form of primary Sjogren's syndrome. (16166103)
2006
38
Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome. (15975969)
2006
39
Distinct recognition of antibodies to centromere proteins in primary Sjogren's syndrome compared with limited scleroderma. (16414973)
2006
40
Changes in salivary gland immunohistology and function after rituximab monotherapy in a patient with Sjogren's syndrome and associated MALT lymphoma. (15576414)
2005
41
Sjogren's syndrome: concomitant H. pylori infection and possible correlation with clinical parameters. (15797493)
2005
42
Antifodrin antibodies in Sjogren's syndrome: a review. (16126964)
2005
43
Primary Sjogren's syndrome presenting as a generalized chorea. (15823485)
2005
44
Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjogren's syndrome. (15593200)
2004
45
Liver involvement in primary Sjogren's syndrome]. (15678893)
2004
46
Hyperprolactinemia in Sjogren's syndrome: a patient subset or a disease manifestation? (15182791)
2004
47
Expression of chemokine in the labial glands of patients with Sjogren's syndrome]. (12812666)
2003
48
Amidolytic and peptidolytic activities of immunoglobulin G present in sera from patients with rheumatoid arthritis, Sjogren's syndrome and systemic lupus erythematosus. (9767453)
1998
49
Histologic examination of the NOD-mouse lacrimal glands, a potential model for idiopathic autoimmune dacryoadenitis in Sjogren's syndrome. (8699811)
1996
50
Recurrent parotitis with H2 receptor antagonists in a patient with Sjogren's syndrome. (2899973)
1988

Genetic Variations for Sjogren's Syndrome

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Expression for genes affiliated with Sjogren's Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sjogren's Syndrome

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Pathways for genes affiliated with Sjogren's Syndrome

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Compounds for genes affiliated with Sjogren's Syndrome

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Sjogren's Syndrome according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1glutamate4411.3HSPG2, ICA1, APOH, LTF, CD79A, SPTAN1
2phosphatidylserine44 28 1113.2RNPC3, CD79A, LTF, APOH, HSPG2
3creatinine4411.2LCN1, TNFSF13B, APOH, LTF, CD79A
4phosphatidylcholine4411.1HSPG2, APOH, LTF, CD79A
5vitamin b124411.0CD79A, LTF, APOH
6betacarotene4411.0LCN1, APOH, CD79A
7rituximab44 49 1113.0CD79A, APOH, TNFSF13B
8hypothiocyanite44 2411.9CD79A, LTF
9gluten4410.9APOH, CD79A
10lactulose4410.8CD79A, LTF
11thiocyanate44 2411.8LTF, CD79A
12pneumococcal4410.8LTF, CD79A
13azathioprine44 49 2 1113.7CD79A, LTF, APOH
14sialic acid4410.7CD79A, LTF, APOH
15blys4410.7CD79A, TNFSF13B
16piroxicam44 1111.6HSPG2, CD79A
17pilocarpine44 28 1112.4HSPG2, CD79A

GO Terms for genes affiliated with Sjogren's Syndrome

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16Gene Ontology
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Cellular components related to Sjogren's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonucleoprotein complexGO:03052910.7TRIM21, TROVE2, SSB

Products for genes affiliated with Sjogren's Syndrome

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Sources for Sjogren's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet