Sjogren's Syndrome malady

MedlinePlus: Sjogren's syndrome is a disease that causes dryness in your mouth and eyes. it can also lead to dryness in other places that need moisture, such as your nose, throat and skin. most people who get sjogren's syndrome are older than 40. nine of 10 are women. sjogren's syndrome is sometimes linked to rheumatic problems such as rheumatoid arthritis. sjogren's syndrome is an autoimmune disease. if you have an autoimmune disease, your immune system, which is supposed to fight disease, mistakenly attacks parts of your own body. in sjogren's syndrome, your immune system attacks the glands that make tears and saliva. it may also affect your joints, lungs, kidneys, blood vessels, digestive organs and nerves. the main symptoms are: dry eyes dry mouth treatment focuses on relieving symptoms. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Sjogren's Syndrome, also known as sjogrens syndrome, is related to systemic lupus erythematosus and rheumatoid arthritis. An important gene associated with Sjogren's Syndrome is SSB (Sjogren syndrome antigen B (autoantigen La)), and among its related pathways are Immune System and IL-6 Pathway. The compounds cyclophosphamide and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology: An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.⁶

NINDS: Sj³¹

Wikipedia: Sjögren\'s syndrome (pronounced pron.: /ˈʃoʊɡrɨnz/ SHOH-grinz in English), also known as \"Sicca...⁴⁴ more...

Aliases & Descriptions:

sjogren's syndrome 6 23 sjogrens syndrome 8 32 sicca syndrome 6 43

sjögren's syndrome 31 xerodermosteosis 6

Diseases related to sjogren's syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 953)

id	Related Disease	Score	Top Affiliating Genes
1	systemic lupus erythematosus	35.8	PDCD1, FOXP3, IRF5, FASLG, MBL2, PTPN22
2	rheumatoid arthritis	34.3	PADI4, CIITA, HLA-DRB1, PTPN22, NFKBIL1
3	arthritis	31.8	SELL, VIP, MMP3, IL17A, IL1B, IL6
4	sialadenitis	30.9	CD28, CD4, CD80, ITGAL, HSPG2, CALR
5	malt lymphoma	30.2	S100A8, CD79A, CD80, CD40, ITGA4, IL6
6	keratoconjunctivitis sicca	30.1	IL4, AQP5, HSPG2, TRIM21, NGF, LTF
7	adult t-cell leukemia	29.9	KIR2DL1, KIR2DL3, CIITA, CD4, CD40, ITGAL
8	t-cell large granular lymphocyte leukemia	29.9	GZMB, IL18, IL2, FASLG, TRB@, CSF2
9	limited scleroderma	29.9	CENPB, CENPC1, IL2, IL2RA
10	paralysis	29.4	PIK3C2A, ATP1A2, CD274, IL10, IL1B, HSPG2
11	t-cell leukemia	29.1	CHUK, LBR, JUN, CD28, CD4, CD40
12	multiple sclerosis	29.0	CD40, IL12A, IL1B, IL2RA, APOE, CCR5
13	large granular lymphocyte leukemia	28.3	KIR2DL1, KIR2DL3, LBR, IL10, IL18, IL2
14	hepatitis	28.3	XDH, GZMB, FASLG, FAS, IFNA1, IFNB1
15	lupus erythematosus	27.7	PIK3C2A, PDCD1, RETN, KIR2DS3, KIR2DS5, KIR2DL1
16	pleurisy	27.0	MUC16, LCN1, IL10, IL17A, IL18, IL1B
17	periodontitis	26.9	MMP3, MMP9, FCGR3A, IL10, IL17A, IL1B
18	periodontal disease	26.8	S100A8, S100A9, CD79A, ITGB1, MMP3, MMP9
19	hepatitis c	26.7	CIITA, JUN, CD28, CD40LG, IL10, IL18
20	pericarditis	26.6	PIK3C2A, SAR1B, IL1B, IL2, IL6, ALB
21	cataract	25.2	PCNA, PARP1, LAMA3, MMP3, MIP, IL13
22	retinoblastoma	23.4	KITLG, PCNA, RBBP4, VIP, PARP1, CHRM3
23	leukemia	22.6	PIK3C2A, PDCD1, RETN, KIR2DS3, KIR2DS5, KIR2DL1
24	lymphocytic leukemia	22.4	KIR2DL1, KIR2DL3, KITLG, KIR3DL1, SELL, VCAM1
25	pancreatitis	20.7	PIK3C2A, RETN, KITLG, PCNA, SELE, VIP
26	neuropathy	20.5	PIK3C2A, RETN, RBBP4, SELE, VIP, PARP1
27	alzheimer's disease	20.3	KITLG, SELL, VIP, PARP1, PADI4, BDNF
28	connective tissue disease	14.8	S100A9, CENPB, APOH, HSPG2, CAST, CALR
29	lymphomatoid papulosis	14.5	B2M, GZMB, FASLG, FAS, CCL17, TRB@
30	allergic contact dermatitis of eyelid	14.4	SELE, FLG, IL17A, CCL27, ICAM1, DYT10
31	extrinsic allergic alveolitis	14.4	SELL, B2M, CD28, ITGAL, IL2RA, CCL3
32	relapsing polychondritis	14.4	S100A8, CD79A, IL10, IL1RAPL2, APOH, CCL4
33	autoimmune thyroiditis	14.4	CIITA, CD59, CD80, CD40, CD55, ITGAL
34	bronchitis	14.3	VIP, S100A8, S100A9, DYT10, LTF, PRTN3
35	nodular goiter	14.3	CD28, CD86, CD80, ICAM1, CTLA4, TSHR
36	cd40 ligand deficiency	14.3	CD79A, CD40LG, CD40, AICDA, SRF
37	primary biliary cirrhosis	14.3	PDCD1, SELL, CIITA, LBR, CENPB, CD79A
38	dry eye syndrome	14.2	MUC5AC, AQP5, HSPG2, LTF
39	reactive arthritis	14.2	CD79A, IFNB1, HLA-B, CR1, LTF, TAP2
40	immunodeficiency with hyper igm	14.2	CD79A, CD40LG, CD40, AICDA
41	lymphoproliferative syndrome	14.2	KIR3DL1, LBR, B2M, CD59, CD4, CD40LG
42	selective iga deficiency disease	14.2	CD79A, CD40LG, IL10, IL4, LTA
43	immunoglobulin alpha deficiency	14.2	CD79A, CD40LG, MBL2, HLA-DQB1, TNFRSF13B
44	erythema multiforme	14.1	CD79A, FAS, CCL17, CCL5, ICAM1, HSPG2
45	bullous pemphigoid	14.1	CIITA, LAMA3, CD79A, ITGAL, FLG, IL13
46	immunodeficiency with hyper igm type 1	14.1	CD79A, CD40LG, CD40, IL4, AICDA
47	lymphoblastic lymphoma	14.1	S1PR1, CD4, MME, FASLG, FAS, ICAM1
48	birdshot chorioretinopathy	14.1	KIR2DS3, KIR2DL1, KIR3DS1, KIR2DS4, KIR3DL1, KIR2DS2
49	systemic scleroderma	14.1	SELE, SELL, VCAM1, CIITA, MUC16, S100A8
50	guttate psoriasis	14.1	KIR2DS1, ITGAL, HLA-C, TRB@

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to sjogren's syndrome:

²²

MGI Mouse Phenotypes related to sjogren's syndrome:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.0	PDCD1, PCNA, CHUK, BAK1, S1PR1, CD28
2	respiratory system phenotype	MP:0005388	10.6	SELL, BDNF, CHRM1, CHRM3, ATP1A2, MECP2
3	embryogenesis phenotype	MP:0005380	10.2	PARP1, CHUK, S1PR1, CENPC1, ATP1A2, ITGA4
4	craniofacial phenotype	MP:0005382	10.1	KITLG, BDNF, LBR, LAMA3, ITGA4, FOXP3
5	endocrine/exocrine gland phenotype	MP:0005379	9.8	SELL, CHRM3, XDH, CENPB, CD40LG, ITPR3
6	renal/urinary system phenotype	MP:0005367	9.8	PDCD1, CHUK, CHRM3, BAK1, BAX, CD180
7	hearing/vestibular/ear phenotype	MP:0005377	9.1	KITLG, PARP1, BDNF, CHUK, CHRM1, BAK1
8	no phenotypic analysis	MP:0003012	8.8	PCNA, VCAM1, PARP1, BDNF, MUC1, LBR
9	liver/biliary system phenotype	MP:0005370	8.6	RETN, CHRM3, IL1R1, IL2, IL6, MAP2K4
10	immune system phenotype	MP:0005387	8.6	SELL, PADI4, CIITA, CHUK, MUC5AC, BAK1
11	nervous system phenotype	MP:0003631	8.5	PDCD1, KITLG, PARP1, BDNF, CHUK, CHRM1
12	normal phenotype	MP:0002873	8.5	SELE, VIP, PADI4, BDNF, CIITA, MUC1
13	other phenotype	MP:0005395	8.1	CD40LG, ITGB1, MME, IL13, IL2, APOE
14	integument phenotype	MP:0010771	8.0	KITLG, PARP1, BDNF, CHUK, MUC1, LBR
15	mortality/aging	MP:0010768	7.8	PIK3C2A, PDCD1, KITLG, SELE, VCAM1, PARP1
16	skeleton phenotype	MP:0005390	7.8	KITLG, CHUK, BAK1, BAX, JUN, ITGB1
17	reproductive system phenotype	MP:0005389	7.5	VIP, CHUK, B2M, CD59, ITGB1, MMP9
18	muscle phenotype	MP:0005369	7.2	PDCD1, CHRM3, BAX, S1PR1, XDH, ATP1A2
19	adipose tissue phenotype	MP:0005375	7.1	PIK3C2A, RETN, CHRM3, LBR, XDH, MECP2
20	digestive/alimentary phenotype	MP:0005381	7.1	KITLG, BDNF, CHRM1, CHRM3, MUC1, MUC5AC
21	homeostasis/metabolism phenotype	MP:0005376	7.0	PIK3C2A, RETN, KITLG, SELE, SELL, VIP
22	behavior/neurological phenotype	MP:0005386	7.0	SELE, VIP, BDNF, CHRM1, CHRM3, UBR3
23	growth/size phenotype	MP:0005378	6.6	PIK3C2A, KITLG, SELE, VCAM1, PARP1, PADI4
24	vision/eye phenotype	MP:0005391	6.1	PDCD1, KITLG, SELE, BDNF, CHUK, CHRM3
25	tumorigenesis	MP:0002006	6.0	KITLG, SELL, CHUK, MUC1, B2M, ITGAL
26	cellular phenotype	MP:0005384	5.9	PDCD1, KITLG, PCNA, SELE, SELL, VCAM1
27	cardiovascular system phenotype	MP:0005385	4.8	PDCD1, KITLG, SELE, SELL, VCAM1, CHUK

Articles related to sjogren's syndrome:

(show top 50)    (show all 280)

id	Title	Authors	Year	Affiliating Genes
1	Genetic association between methyl-CpG binding protei n 2 (MECP2) and primary Sjogren's syndrome. (20215141)	Cobb B.L.... Sawalha A.H.	2010	MECP2
2	Salivary epithelial cells from Sjogren's syndrome pat ients are highly sensitive to anoikis induced by TLR-3 ligation. (20685081)	Manoussakis M.N.... Maratheftis C.I.	2010	TLR3
3	Assessment of alveolar epithelial permeability with T c-99m DTPA aerosol scintigraphy in patients with Sjogren syndrome. (19582462)	Pirildar T.... Sayit E.	2010	HSPG2
4	Interferon-gamma is increased in patients with primar y Sjogren's syndrome and Raynaud's phenomenon. (18571695)	Willeke P.... Becker H.	2009	IFNG
5	Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjogren's syndrome. (18089681)	Liu M.F.... Weng M.Y.	2008	CD4, IL2RA
6	CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. (18354239)	Barone F.... Pitzalis C.	2008	CCL21, CXCL13, CXCL12
7	Variant form of STAT4 is associated with primary Sjogren's syndrome. (18273036)	Korman B.D.... Illei G.G.	2008	STAT4
8	Constitutive STAT3 activation in peripheral CD3(+) cells from patients with primary Sjogren's syndrome. (18189193)	Ramos H.L.... Alcocer-Varela J.	2008	STAT3
9	Systemic increase in type I interferon activity in Sjogren's syndrome: a putative role for plasmacytoid dendritic cells. (18581327)	Wildenberg M.E.... Versnel M.A.	2008	IFNB1
10	Clinical significance of autoantibodies recognizing Sjogren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjogren's syndrome. (17286756)	Goeb V.... Vittecoq O.	2007	SPTAN1
11	Anti-beta2-glycoprotein I in Sjogren's syndrome is associated with parkinsonism. (17057945)	Hassin-Baer S.... Ehrenfeld M.	2007	APOH
12	Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjogren's syndrome. (17552056)	Barcellos K.S.... Andrade L.E.	2007	TRIM21, SSB, TROVE2
13	CD40-CD40 ligand signal induces the intercellular adhesion molecule-1 expression through nuclear factor-kappa B p50 in cultured salivary gland epithelial cells from patients with Sjogren's syndrome. (17278022)	Saito M.... Ogawa N.	2007	ICAM1
14	Endothelial nitric oxide synthase +894 polymorphism is associated with recurrent salivary gland swelling and early onset in patients with primary Sjogren's syndrome. (17881665)	Pertovaara M.... Hurme M.	2007	NOS3
15	Autoantibodies from Sjogren's syndrome trigger apoptosis in salivary gland cell line. (17894006)	Sisto M.... Mitolo V.	2007	TRIM21
16	Sjogren's syndrome--study of autoantigens and autoantibodies. (17992591)	Routsias J.G.... Tzioufas A.G.	2007	SPTBN1
17	B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjogren's syndrome. (16507175)	Ittah M.... Mariette X.	2006	TNFSF13B
18	Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome. (16477017)	Gottenberg J.E.... Mariette X.	2006	TRAPPC10
19	Th2 cytokine genotypes are associated with a milder form of primary Sjogren's syndrome. (16166103)	Pertovaara M.... Hurme M.	2006	IL4, IFNG, IL13
20	Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjogren's syndrome. (15940770)	Konttinen Y.T.... Hukkanen M.	2005	AQP5
21	Identification of tear lipocalin as a novel autoantigen target in Sjogren's syndrome. (16249071)	Navone R.... Puccetti A.	2005	SPTAN1, LCN1
22	Autoantibodies against carbonic anhydrase II are increased in renal tubular acidosis associated with Sjogren syndrome. (15694905)	Takemoto F.... Uchida S.	2005	CA2
23	Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjogren's syndrome. (15986367)	Hansen A.... Dorner T.	2005	CXCL13, CCR9, CXCR5
24	Frequency of chromosomal aberrations involving MALT1 in mucosa-associated lymphoid tissue lymphoma in patients with Sjogren's syndrome. (14760068)	Streubel B.... Raderer M.	2004	MALT1
25	A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. (15485632)	Li H.... Zhuang Y.	2004	ID3
26	Normalization of anticardiolipin antibodies following rituximab therapy for marginal zone lymphoma in a patient with Sjogren's syndrome. (15448217)	Harner K.C.... Drabick J.J.	2004	APOH
27	Polymorphisms of IL-1 beta gene in Japanese patients with Sjogren's syndrome and systemic lupus erythematosus. (15088297)	Muraki Y.... Sumida T.	2004	IL1B
28	Increased levels of interleukin-10 in saliva of Sjogren's syndrome patients. Correlation with disease activity. (15599664)	Bertorello R.... Cordone G.	2004	IL10
29	Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjogren's syndrome. (15174222)	Shiraiwa H.... Sawada S.	2004	GRAP
30	In primary Sjogren's syndrome, HLA class II is associated exclusively with autoantibody production and spreading of the autoimmune response. (12905478)	Gottenberg J.E.... Mariette X.	2003	HLA-DRB1
31	Interleukin 10 (IL-10) influences autoimmune response in primary Sjogren's syndrome and is linked to IL-10 gene polymorphism. (12233881)	Anaya J.M.... Gallagher G.	2002	IL10
32	Expression of TNF-related apoptosis inducing ligand (TRAIL) on infiltrating cells and of TRAIL receptors on salivary glands in patients with Sjogren's syndrome. (12508770)	Matsumura R.... Okumura K.	2002	TNFRSF10A
33	SS-56, a novel cellular target of autoantibody responses in Sjogren syndrome and systemic lupus erythematosus. (11560955)	Billaut-Mulot O.... Bahr G.M.	2001	TRIM68
34	Polymorphisms of the mannose binding lectin gene in patients with Sjogren's syndrome. (11302870)	Wang Z.Y.... Kumagai S.	2001	MBL2
35	Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren's syndrome. (11247557)	Tsubota K.... Ishida N.	2001	ATP1A2, AQP5
36	'Lymphoid' chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjogren's syndrome patients: possible participation in lymphoid structure formation. (11229473)	Xanthou G.... Moutsopoulos H.M.	2001	CXCL13, CCL17, CCL18
37	Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjogren's syndrome. (11710719)	Amft N.... Buckley C.D.	2001	CXCL13, CXCL12
38	Genetic association between interleukin-10 promoter region polymorphisms and primary Sjogren's syndrome. (11212157)	Hulkkonen J.... Hurme M.	2001	IL10
39	Lack of association between mannose-binding lectin gene polymorphisms and primary Sjogren's syndrome. (11145046)	Mullighan C.G.... Gordon T.P.	2000	MBL2
40	Association between HLA-DRB1*15 and secondary Sjogren's syndrome in patients with rheumatoid arthritis. (11093441)	Mattey D.L.... Ollier W.E.	2000	HLA-DRB1
41	IgA and IgG autoantibodies against alpha-fodrin as markers for Sjogren's syndrome. Systemic lupus erythematosus. (11093442)	Witte T.... Schmidt R.E.	2000	SPTAN1, CD79A
42	Light chain variable (VL) sequences of rheumatoid factors (RF) in patients with primary Sjogren's syndrome (pSS): moderate contribution of somatic hypermutation. (10564552)	Elagib K.E.... Natvig J.B.	1999	IGSF10
43	Autoantibodies to La/SSB in patients with primary Sjogren's syndrome (pSS) are associated with upregulation of La/SSB mRNA in minor salivary gland biopsies (MSGs). (10585759)	Tzioufas A.G.... Moutsopoulos H.M.	1999	GAPDH, SSB, TROVE2
44	Anti-120-kDa alpha-fodrin immune response with Th1-cytokine profile in the NOD mouse model of Sjogren's syndrome. (9808203)	Yanagi K.... Hayashi Y.	1998	SPTAN1
45	Functional reserve of the exocrine pancreas in Sjogren's syndrome (9102710)	D'Ambrosi A.... La Corte R.	1997	GJA8
46	Expression of selectins (CD62 E,L,P) and cellular adhesion molecules in primary Sjogren's syndrome: questions to immunoregulation. (8674240)	Aziz K.E.... Wakefield D.	1996	TRAF3IP2
47	Neutral endopeptidase (EC 3.4.24.11) in labial salivary glands in healthy controls and in patients with Sjogren's syndrome. (8774178)	Konttinen Y.T.... Polak J.M.	1996	MME, VIP
48	Identification of Ro(SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjogren's syndrome. (8596150)	Namekawa T.... Sumida T.	1995	SSB
49	Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndrome. (8509947)	Saito I.... Miyasaka N.	1993	ICAM1, ITGA4, ITGAL
50	The diagnostic value of salivary fluid levels of beta 2-microglobulin, lysozyme and lactoferrin for primary Sjogren's syndrome. (1486744)	Markusse H.M.... Breedveld F.C.	1992	B2M, LTF, LYZ

Genes related to sjogren's syndrome according to GeneCards:

(show top 50)    (show all 254)

id	Symbol	Description	Score	GeneCards Section Context
1	SSB	Sjogren syndrome antigen B (autoantigen La)	11.1	Publications, Aliases & Descriptions, Summaries, Orthologs (show all 6 sections) Transcripts, Databases
2	TRIM21	tripartite motif containing 21	11.1	Summaries, Publications, Aliases & Descriptions
3	SIL1	SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)	11.1	Summaries, Aliases & Descriptions, Publications
4	SSSCA1	Sjogren syndrome/scleroderma autoantigen 1	11.1	Aliases & Descriptions, Orthologs, Transcripts, Summaries
5	TROVE2	TROVE domain family, member 2	11.1	Aliases & Descriptions, Publications
6	SSNA1	Sjogren syndrome nuclear autoantigen 1	11.1	Transcripts, Aliases & Descriptions, Orthologs
7	LCN1	lipocalin 1	11.1	Summaries, Publications
8	ICA1	islet cell autoantigen 1, 69kDa	11.0	Publications, Summaries
9	GOLGA1	golgin A1	11.0	Summaries
10	LOC100533757	Sjogren syndrome antigen B (autoantigen La) pseudogene	11.0	Aliases & Descriptions
11	LOC653588	Sjogren syndrome antigen B (autoantigen La) pseudogene	11.0	Aliases & Descriptions
12	LOC389465	Sjogren syndrome antigen B pseudogene	11.0	Aliases & Descriptions
13	RNY1	RNA, Ro-associated Y1	11.0	Summaries
14	HSPG2	heparan sulfate proteoglycan 2	11.0	Publications
15	LTF	lactotransferrin	11.0	Publications
16	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
17	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
18	SAR1B	SAR1 homolog B (S. cerevisiae)	11.0	Publications
19	SPTAN1	spectrin, alpha, non-erythrocytic 1	11.0	Functions, Publications
20	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
21	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
22	CA2	carbonic anhydrase II	11.0	Publications
23	CHRM3	cholinergic receptor, muscarinic 3	11.0	Publications
24	PRTN3	proteinase 3	11.0
25	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
26	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
27	CALR	calreticulin	11.0	Publications
28	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
29	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
30	B2M	beta-2-microglobulin	11.0	Publications
31	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
32	TRB@	T cell receptor beta locus	11.0	Publications
33	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
34	CD40LG	CD40 ligand	11.0
35	AQP5	aquaporin 5	11.0	Publications
36	CENPB	centromere protein B, 80kDa	11.0	Publications
37	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
38	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	11.0	Publications
39	CCL21	chemokine (C-C motif) ligand 21	11.0	Publications
40	CXCL13	chemokine (C-X-C motif) ligand 13	11.0	Publications
41	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	11.0	Publications
42	POLR3K	polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa	11.0
43	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
44	CENPC1	centromere protein C 1	11.0	Publications
45	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
46	DLAT	dihydrolipoamide S-acetyltransferase	11.0
47	MIP	major intrinsic protein of lens fiber	11.0
48	S100A6	S100 calcium binding protein A6	11.0
49	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	11.0
50	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications

Pathways related to sjogren's syndrome according to GeneDecks:

(show top 50)    (show all 205)

id	Pathway	Score	Top Affiliating Genes
1	Immune System38	11.1	PDCD1, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1, KIR2DS4
2	IL-6 Pathway36	10.8	PIP, BAX, CD80, IL10, IL12A, IL18
3	Lymphocyte Signaling3	10.8	KITLG, CIITA, B2M, CD4, MME, FOXP3
4	Cell adhesion molecules (CAMs)20	10.7	SELL, CD28, CD86, CD4, CD80, CD40
5	Antigen processing and presentation20	10.6	KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1
6	Immune response NFAT in immune response10	10.5	CHUK, CD28, CD79A, CD86, CD80, ITPR1
7	Viral myocarditis20	10.5	CD28, CD86, CD40LG, CD80, CD40, CD55
8	RAR-Gamma-RXR-Alpha Degradation36	10.3	PIP, CD80, IL12A, IL2, IL23A, MAP2K4
9	Bacterial infections in CF airways41	10.3	CHUK, MUC1, IL1R1, CTSB, TLR1, TLR2
10	Natural killer cell mediated cytotoxicity20	10.1	KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1
11	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	GZMA, GZMB, IL2, IL2RA, FASLG, CCL4
12	NFAT Signaling and Lymphocyte Interactions36	9.8	BAX, CD4, CD80, IL12A, IL13, IL2
13	CD28 Signaling in T-Helper Cell36	9.7	PIK3C2A, CD28, CD86, CD4, ITPR1, ITPR2
14	Graft-versus-host disease20	9.7	KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL2, CD28, CD86
15	Akt Signaling36	9.4	PIP, CHUK, CD28, CD4, CD80, ITGAL
16	Regulation of eIF4 and p70S6K36	9.3	BAX, CD4, CD80, ITGA4, ITGAL, ITGB1
17	TRAF Pathway36	9.3	CHUK, JUN, IL12A, IL1B, IL1R1, MAP2K4
18	THC Differentiation Pathway36	9.3	CD28, CD86, IL10, IL12A, IL18, IL18R1
19	PGC1Alpha Pathway36	9.2	BAX, CD4, CD80, IL12A, IL13, IL18
20	Intestinal immune network for IgA production20	9.2	CD28, CD86, CD40LG, CD80, CD40, ITGA4
21	Allograft rejection20	9.1	CD28, CD86, CD40LG, CD80, CD40, GZMB
22	Malaria20	9.0	SELE, VCAM1, CD40LG, CD40, ITGAL, IL10
23	ICos-ICosL Pathway in T-Helper Cell36	9.0	PIK3C2A, CHUK, CD28, CD86, CD4, CD80
24	Immune response IL-22 signaling pathway10	9.0	JUN, CD28, CD86, CD4, IL12A, IL2
25	all-trans-Retinoic Acid Signaling in Brain36	8.9	PIP, BAX, CD80, IL10, IL12A, IL13
26	Th1 Differentiation37	8.8	JUN, CD28, CD86, CD4, CD80, IL10
27	Toll-like receptor signaling pathway20	8.8	CHUK, JUN, CD86, CD80, CD40, IRF5
28	Endothelin-1 Signaling Pathway36	8.8	PIP, CD80, IL10, IL12A, IL13, IL18
29	Type I diabetes mellitus20	8.7	CD28, CD86, CD80, GZMB, IL12A, IL1B
30	Toxoplasmosis20	8.7	CIITA, CHUK, LAMA3, CD40LG, CD40, ITGB1
31	JNK Pathway36	8.7	KITLG, BAX, JUN, CD4, CD80, IL18R1
32	MIF Mediated Glucocorticoid Regulation36	8.6	PIP, BAX, CD80, IL10, IL12A, IL13
33	PEDF Induced Signaling36	8.6	PIP, BDNF, CHUK, BAX, CD80, IL10
34	Th17 Differentiation37	8.5	CD28, CD86, CD4, CD80, IL17A, IL1B
35	MIF Regulation of Innate Immune Cells36	8.3	PIP, BAX, JUN, CD80, IL10, IL12A
36	Cytokine-cytokine receptor interaction20	8.0	KITLG, CD40LG, CD40, IL10, IL12A, IL13
37	Rheumatoid arthritis20	8.0	ATP6AP1, JUN, CD28, CD86, CD80, ITGAL
38	Tuberculosis20	7.9	CIITA, BAX, ATP6AP1, FCGR3A, FCGR3B, IL10
39	ERK Signaling36	7.9	PIP, KITLG, CHUK, LAMA3, CD80, ITGA4
40	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	7.8	GZMB, IL17A, IL1B, IL23A, IL4, IL6
41	Cytokine Network36	7.8	IL10, IL12A, IL13, IL18, IL1B, IL2
42	Molecular Mechanisms of Cancer36	7.6	PIP, KITLG, BDNF, BAK1, BAX, JUN
43	Tec Kinases Signaling36	7.6	KITLG, BDNF, BAX, CD28, CD4, CD80
44	PAK Pathway36	7.5	PIP, KITLG, BDNF, BAX, CD80, IL10
45	p38 Signaling36	7.4	PIP, KITLG, BDNF, BAX, CD28, CD4
46	TGF-Beta Pathway36	7.3	KITLG, BDNF, BAX, JUN, CD4, CD80
47	Chagas disease (American trypanosomiasis)20	7.3	CHUK, JUN, IL10, IL12A, IL1B, IL2
48	Antioxidant Action of Vitamin-C36	7.1	PIP, KITLG, BDNF, CHUK, BAX, JUN
49	MAPK Family Pathway36	7.1	KITLG, BDNF, CHUK, BAX, JUN, CD4
50	JAK-STAT Pathway36	6.6	KITLG, BDNF, BAX, JUN, CD4, CD80

Compounds related to sjogren's syndrome according to GeneDecks:

(show top 50)    (show all 446)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	14.2	ITGA4, ITGAL, APOH, MBL2, TRB@, LTF
2	ionomycin32	11.0	CHUK, CD274, CD40, GZMA, CCL4, CCL3
3	allergens32	10.8	PDCD1, CIITA, S100A8, CD79A, CD86, CD40LG
4	ivig32	10.6	PIK3C2A, FCGR3A, IL18R1, IL1RAPL2, FASLG, CCL4
5	threonine32	10.6	CHRM3, MUC5AC, CD4, IL1RAPL2, AQP3, MAP2K4
6	ceramide32	10.6	BAK1, IL18R1, MAP2K4, CASP1, TNF, ABCA1
7	sp 60012532 42	11.4	VCAM1, CD40, IL13, IL17A, MAP2K4, CASP3
8	pge232	10.2	SELE, VIP, VCAM1, CIITA, MUC5AC, CD86
9	progesterone32 42 9 18 9	14.2	PIP, PCNA, MUC16, S100A6, CD55, ITGB1
10	proline32	10.1	BDNF, CIITA, MUC5AC, CD28, CD4, CD80
11	atorvastatin32 34 9 18 9	14.0	PIK3C2A, RETN, SELE, SELL, VCAM1, CD59
12	fmlp32	10.0	SELL, VCAM1, S100A9, CD59, CD55, ITGA4
13	peptidoglycan32	9.9	CIITA, CHUK, IL10, IL1B, IL1R1, MBL2
14	ethanol32 34 9 18 9	13.8	KITLG, BDNF, CHRM1, CHRM3, MUC1, MUC5AC
15	estrogen32	9.6	PIP, RETN, PCNA, VIP, BDNF, MUC5AC
16	okt332	9.6	SELE, VCAM1, LBR, CD79A, CD40LG, IL10
17	flagellin32	9.2	S100A8, CD86, IL18, IL1B, IFNB1, CASP1
18	12-o-tetradecanoylphorbol 13-acetate32	9.2	CHUK, BAK1, LBR, CD4, ITGB1, MME
19	polymyxin b32	9.1	SELE, VCAM1, IL10, IL1B, IL4, IL6
20	c2ceramide32	9.0	PARP1, CHUK, BAX, JUN, IL1B, CASP3
21	creatinine32	9.0	RETN, KITLG, PCNA, SELE, SELL, BDNF
22	azathioprine32 34 9 9	11.8	PCNA, S100A6, XDH, CD79A, CD59, ITGAL
23	superoxide32 18	9.8	PIK3C2A, KITLG, SELL, VCAM1, CHUK, BAK1
24	mip 1alpha32	8.6	IL10, IL13, IL1B, IL4, IL6, CCL4
25	paraffin32	8.6	PIP, KITLG, PCNA, SELL, VCAM1, MUC1
26	simvastatin32 34 42 9 18 9	13.4	PIK3C2A, KITLG, SELE, SELL, VCAM1, CIITA
27	lipid32	8.4	PIK3C2A, RETN, KIR2DL1, KITLG, KIR3DL1, SELE
28	wortmannin32 42	9.3	PIK3C2A, KITLG, VCAM1, BDNF, CHUK, CHRM3
29	2,5-oligoadenylate32	8.3	B2M, IL10, IL2, IL2RA, IL6, IFNA1
30	cholesterol32 9 18 9	11.2	PIK3C2A, RETN, KITLG, SELE, VCAM1, BDNF
31	pentoxifylline32 9 9	10.2	SELL, VCAM1, LBR, ITGA4, IL10, IL13
32	ribavirin32 34 9 9	11.1	LBR, CD40LG, MMP9, IL10, IL18, IL2
33	thapsigargin32 42	9.1	PCNA, VIP, BDNF, BAK1, S100A6, ITGAL
34	arsenite32 18	8.9	PCNA, PARP1, CHUK, BAX, LBR, JUN
35	butyrate32	7.8	KITLG, PCNA, MUC1, BAK1, BAX, B2M
36	rosiglitazone32 9 18 9	10.7	RETN, SELE, VCAM1, JUN, MMP9, IL18
37	vegf32	7.7	PIK3C2A, RETN, KITLG, PCNA, SELE, VIP
38	15-deoxy-delta-12,14-prostaglandin j232	7.5	VCAM1, JUN, IL10, IL1B, IL4, IL6
39	triptolide32	7.3	PARP1, BAX, JUN, CD86, CD40, MMP3
40	lactate32	7.3	PIK3C2A, KITLG, PCNA, SELE, SELL, VIP
41	quercetin32 42 9 18 9	11.3	PIK3C2A, SELE, VCAM1, PARP1, CHUK, BAK1
42	tamoxifen32 34 9 9	10.2	PIP, PCNA, SELE, VCAM1, BDNF, CHUK
43	gm-csf32	6.9	KITLG, IL10, IL13, IL18, IL1B, IL2
44	vitamin d32	6.9	LBR, B2M, JUN, CD79A, MMP3, IL10
45	ly29400232	6.9	PIK3C2A, RETN, SELE, CHUK, S1PR1, JUN
46	serine32	6.1	KITLG, SELE, SELL, VIP, VCAM1, BDNF
47	thymidine32 18	6.9	KITLG, PCNA, VIP, BDNF, CIITA, MUC1
48	pd 98,05932	5.8	KITLG, VCAM1, PARP1, BDNF, CHUK, MUC5AC
49	genistein32 9 18 9	8.1	KITLG, PCNA, SELE, SELL, VCAM1, PARP1
50	retinoic acid32 42 18	7.1	KITLG, KIR2DS4, PCNA, SELL, VCAM1, PARP1

Cellular components related to sjogren's syndrome according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	ER to Golgi transport vesicle membrane	GO:012507	10.2	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C
2	MHC class II protein complex	GO:042613	10.1	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
3	integral to plasma membrane	GO:005887	10.1	CHRM3, CHRM1, SELL, KIR3DL1, KIR2DS4, KIR3DS1
4	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.1	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C
5	transport vesicle membrane	GO:030658	10.0	HLA-DRB5, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, ICA1
6	membrane raft	GO:045121	10.0	TLR4, ABCA1, TNFRSF1B, TNF, FAS, ITPR1
7	external side of plasma membrane	GO:009897	10.0	CXCR3, IL4, IL17A, IL13, FCGR3A, ITGB1
8	Golgi lumen	GO:005796	9.5	TGFB1, NGF, HSPG2, MUC5AC, MUC19, MUC16
9	cell surface	GO:009986	9.5	HMGB1, TNF, CR1, NOTCH2, TLR2, TLR3
10	plasma membrane	GO:005886	8.8	CR1, ICAM1, IGKC, CCR7, CCR9, CCR5
11	cytosol	GO:005829	8.7	SSNA1, SPTBN1, SPTAN1, CTSH, PTEN, TNFSF13
12	extracellular region	GO:005576	6.7	SIAE, LYZ, CSF2, CXCL9, CXCL13, CXCL12
13	extracellular space	GO:005615	6.7	TGFA, LTA, NGF, COLQ, CTSB, CTSH

Biological processes related to sjogren's syndrome according to GeneDecks:

(show top 50)    (show all 86)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte cell-cell adhesion	GO:007159	11.0	SELE, VCAM1, SYK, CD40LG, ITGA4, ITGAL
2	B cell differentiation	GO:030183	10.9	IL10, TSHR, AICDA, IL4, ITGB1, ITGA4
3	chemotaxis	GO:006935	10.9	CCL4, CCL27, DEFB4A, S100A8, CCR5, CCL17
4	chronic inflammatory response	GO:002544	10.8	CCL5, S100A9, VCAM1, S100A8, CXCL13
5	regulation of immune response	GO:050776	10.8	HLA-C, B2M, HLA-B, HLA-A, ICAM1, IGKC
6	T cell costimulation	GO:031295	10.8	CD86, CD80, CD28, PDCD1, CD274, CCL21
7	B cell proliferation	GO:042100	10.6	CD40, IL10, IFNB1, CD40LG, CD79A
8	positive regulation of interleukin-12 production	GO:032735	10.6	CD40, IL23A, CCR7, TLR2, TLR3, TLR4
9	positive regulation of MHC class II biosynthetic process	GO:045348	10.6	TLR4, CIITA, CD40LG, IL10, IL4, IFNG
10	positive regulation of osteoclast differentiation	GO:045672	10.5	IL17A, IL23A, CCL5, IFNG, CA2, TNF
11	negative regulation of growth of symbiont in host	GO:044130	10.5	TNF, TLR2, LTA, IFNG, MBL2, IL10
12	defense response to bacterium	GO:042742	10.4	LYZ, CXCL13, DEFB4A, SYK, TLR4, IFNB1
13	interferon-gamma-mediated signaling pathway	GO:060333	10.3	VCAM1, CIITA, B2M, IRF5, IFNG, HLA-DQB1
14	cell surface receptor signaling pathway	GO:007166	10.3	CD274, CCR5, IFNB1, IFNG, TNFRSF13B, AGER
15	response to virus	GO:009615	10.3	STAT1, IL12A, CXCL12, CHUK, FOXP3, TNF
16	humoral immune response	GO:006959	10.2	IL6, CD28, IFNG, IFNB1, TRAF3IP2, LTA
17	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.1	TLR3, FASLG, TRAF3IP2, TNF, CHUK, TLR4
18	cellular response to lipopolysaccharide	GO:071222	10.1	ICAM1, IL10, IFNG, TNFRSF1B, NOS2, NFKBIL1
19	positive regulation of tumor necrosis factor production	GO:032760	10.1	TLR3, TLR2, IFNG, CCL3, TLR4, IL23A
20	innate immune response	GO:045087	10.1	POLR3K, PRSS2, DEFB4A, SYK, TLR4, TLR3
21	T cell receptor signaling pathway	GO:050852	9.9	HLA-DQA1, HLA-DQB1, HLA-DRB1, NFKBIA, HLA-DPB1, HLA-DRB5
22	response to lipopolysaccharide	GO:032496	9.9	CXCL10, SELE, S100A9, S100A8, JUN, IL12A
23	cellular response to mechanical stimulus	GO:071260	9.9	CD40, TLR3, TNFRSF10A, CASP1, FAS, MAP2K4
24	cell-cell signaling	GO:007267	9.8	IL1B, IL2, FASLG, CCL4, CCL27, CCR5
25	positive regulation of chemokine production	GO:032722	9.8	TLR4, TLR3, TLR2, TNF, IL18, IL6
26	signal transduction	GO:007165	9.8	IL1B, FASLG, FAS, MAP2K4, TLR2, TNFRSF10A
27	positive regulation of inflammatory response	GO:050729	9.7	IL23A, IL18, IL2, CCL3, TLR2, TLR3
28	positive regulation of NF-kappaB import into nucleus	GO:042346	9.7	TLR4, TLR3, TLR2, IL1B, IL23A, TNF
29	positive regulation of T cell proliferation	GO:042102	9.6	IL23A, ITGAL, TNFRSF13C, IL12A, IFNG, CCL5
30	response to ethanol	GO:045471	9.6	BAK1, MMP9, IL13, S100A8, S100A9, STAT3
31	positive regulation of smooth muscle cell proliferation	GO:048661	9.5	IL6, CCL5, TNF, TGM2, JUN, S1PR1
32	positive regulation of chemokine biosynthetic process	GO:045080	9.5	IL1B, IFNG, TLR3, IL4, TNF
33	positive regulation of apoptotic process	GO:043065	9.5	BAK1, TLR3, NOS3, CTLA4, CYR61, TNF
34	induction of apoptosis	GO:006917	9.5	TNF, TGM2, TGFB1, TLR2, LTA, NOTCH2
35	positive regulation of B cell proliferation	GO:030890	9.5	IL2, TNFRSF13C, TLR4, CD40LG, CD40, IL4
36	immune response	GO:006955	9.4	CCR7, IL18R1, IL18, IL17A, IL13, IL12A
37	positive regulation of interferon-gamma production	GO:032729	9.3	LTA, TLR4, CD40LG, TNF, IL23A, IL1B
38	cell proliferation	GO:008283	9.2	BAK1, TNFRSF17, TXN, IL2RA, CD274, CHRM3
39	response to radiation	GO:009314	9.0	CXCL12, JUN, IL18, NGF, MMP9, TGFB1
40	inflammatory response	GO:006954	9.0	TGFB1, TLR3, TLR2, TLR1, AGER, NGF
41	lipopolysaccharide-mediated signaling pathway	GO:031663	9.0	TLR4, CCL3, IL18, IL1B, TNF, STAT1
42	aging	GO:007568	8.9	ATP6AP1, JUN, TGFB1, PTGS1, VCAM1, CCL5
43	cytokine-mediated signaling pathway	GO:019221	8.8	ICAM1, HLA-A, HLA-B, HLA-C, HLA-DQA1, HLA-DQB1
44	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.8	ICAM1, TLR2, AGER, NFKBIA, TNF, MALT1
45	elevation of cytosolic calcium ion concentration	GO:007204	8.6	CCR9, CCR5, CCR7, CXCR3, ITPR1, CD55
46	positive regulation of cell proliferation	GO:008284	8.6	TGFB1, CTSH, VIP, CHRM1, CD86, ITGB1
47	response to hypoxia	GO:001666	8.2	IL18, TLR4, TNF, CASP1, FAS, VCAM1
48	response to drug	GO:042493	8.2	B2M, GAD1, BDNF, STAT3, JUN, TNF
49	anti-apoptosis	GO:006916	7.9	TNF, APOE, FAS, HSPA5, NOS3, NOTCH2
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.9	NFKBIA, SRF, CYR61, TNF, TLR3, POU2F1

Molecular functions related to sjogren's syndrome according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	10.8	CXCL9, CXCL13, CXCL12, CXCL11, CXCL10, CCL5
2	tumor necrosis factor receptor binding	GO:005164	10.5	STAT1, LTA, TNFSF13B, TNFSF13, TNF, FASLG
3	transmembrane signaling receptor activity	GO:004888	10.4	AGER, TLR1, TLR2, TLR3, TLR4, ICAM1
4	receptor activity	GO:004872	10.4	TNFRSF13B, TNFRSF17, NOTCH2, AGER, TLR1, TLR2
5	CCR5 chemokine receptor binding	GO:031730	10.3	CCL4, CCL3, CCL5, STAT3
6	cytokine activity	GO:005125	8.1	IL1B, IL2, IL23A, IL4, IL6, FASLG
7	growth factor activity	GO:008083	6.4	CSF2, CXCL12, TGFB1, TGFA, NGF, IL6
8	protein binding	GO:005515	6.0	TRAPPC10, NOS2, NOS3, NOTCH2, RPLP0, COLQ