MCID: SJG001
MIFTS: 50

Sjogren's Syndrome malady

Summaries for Sjogren's Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Sjogren's syndrome is a disease that causes dryness in your mouth and eyes. it can also lead to dryness in other places that need moisture, such as your nose, throat and skin. most people who get sjogren's syndrome are older than 40. nine of 10 are women. sjogren's syndrome is sometimes linked to rheumatic problems such as rheumatoid arthritis. sjogren's syndrome is an autoimmune disease. if you have an autoimmune disease, your immune system, which is supposed to fight disease, mistakenly attacks parts of your own body. in sjogren's syndrome, your immune system attacks the glands that make tears and saliva. it may also affect your joints, lungs, kidneys, blood vessels, digestive organs and nerves. the main symptoms are: dry eyes dry mouth treatment focuses on relieving symptoms. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Sjogren's Syndrome, also known as sicca syndrome, is related to keratoconjunctivitis sicca and systemic lupus erythematosus. An important gene associated with Sjogren's Syndrome is TRIM21 (tripartite motif containing 21). The drug linolenic acid and the compounds glutamate and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain.

Disease Ontology:8 An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.

NIH Rare Diseases:43 Sjögren syndrome is an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis. the hallmark symptoms of the disorder are dry mouth and dry eyes. in addition, sjogren syndrome may cause skin, nose, and vaginal dryness, and may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain. treatment is symptomatic and supportive and may include moisture replacement therapies, nonsteroidal anti-inflammatory drugs and, in severe cases, corticosteroids or immunosuppressive drugs. last updated: 5/2/2012

NINDS:44 Sj

Genetics Home Reference:21 Sjögren syndrome is a disorder whose main features are dry eyes and a dry mouth. The condition typically develops gradually beginning in middle adulthood, but can occur at any age.

Wikipedia:64 Sjögren\'s syndrome or Sjögren syndrome (pronounced /ˈʃoʊɡrɨn/ SHOH-grin or /ˈʃʌrɡrɨn/... more...

Description from OMIM:47 270150

Aliases & Classifications for Sjogren's Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 47OMIM, 27ICD9CM
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Aliases & Descriptions:

sjogren's syndrome 8 34 61
sicca syndrome 8 43 61
sjogrens syndrome 10 45
sjogren-gougerot syndrome 43
sjögren's syndrome 44
xerodermosteosis 8
sjogren syndrome 43


External Ids:

Disease Ontology8 DOID:12894
NCIt40 C70647
MeSH35 D012859
OMIM47 270150
ICD9CM27 710.2

Related Diseases for Sjogren's Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Sjogren's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis sicca30.2LTF, HSPG2
2systemic lupus erythematosus30.2TNFSF13B
3vasculitis30.0TRIM21, APOH, CD79A, TNFSF13B, LTF
4systemic scleroderma30.0RNPC3, APOH, TNFSF13B, HSPG2, SSB
5primary biliary cirrhosis29.9RNPC3, HSPG2, LTF, CD79A
6mixed connective tissue disease29.9HSPG2, RNPC3, APOH
7rheumatic disease29.9APOH, TRIM21, RNPC3
8hepatitis c29.9RNPC3, HSPG2
9arthritis29.9LTF
10sialadenitis29.9HSPG2
11marinesco-sjögren syndrome10.6
12marinesco-sj�gren syndrome10.4
13n syndrome10.1
14amyloidosis10.1
15sj�gren syndrome10.1
16renal tubular acidosis10.1
17hypersensitivity reaction type ii disease10.0SSB, APOH, TNFSF13B, ICA1, HSPG2, TROVE2
18rheumatoid arthritis10.0HSPG2, TRIM21, LTF, RNPC3, CD79A, SPTAN1
19lupus erythematosus10.0APOH, CD79A, TRIM21, TROVE2
20connective tissue disease10.0APOH, RNPC3, HSPG2, LTF
21nephritis10.0RNPC3, APOH, CD79A, TNFSF13B
22congenital heart block10.0SSB, TRIM21, TROVE2
23lupus nephritis10.0APOH, CD79A
24hepatitis b10.0CD79A, RNPC3, LTF
25cryoglobulinemia10.0APOH, CD79A
26dry eye syndrome10.0HSPG2, LTF
27periodontal disease10.0LTF, CD79A
28thrombocytopenia10.0APOH, CD79A
29antiphospholipid syndrome10.0APOH, CD79A, HSPG2
30purpura10.0HSPG2, CD79A
31pemphigus10.0CD79A
32hepatitis10.0HSPG2
33myopathy10.0SIL1
34myasthenia gravis10.0TNFSF13B
35uveitis10.0RNPC3
36rubella10.0CD79A, RNPC3
37myeloma10.0CD79A, TNFSF13B
38pemphigus vulgaris10.0TNFSF13B
39lactose intolerance10.0LTF
40nephrotic syndrome10.0CD79A
41sneddon syndrome10.0APOH
42common variable immune deficiency10.0TNFSF13B, CD79A
43prostatitis10.0CD79A, LTF
44meningitis10.0CD79A
45reactive arthritis10.0LTF, CD79A
46cryptosporidiosis10.0CD79A
47polyarteritis nodosa10.0LTF
48erythema multiforme10.0HSPG2
49polymyositis10.0HSPG2, RNPC3
50diffuse infiltrative lymphocytosis syndrome10.0

Graphical network of the top 20 diseases related to Sjogren's Syndrome:



Diseases related to sjogren's syndrome

Clinical Features for Sjogren's Syndrome

Sources:
47OMIM
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Clinical features from OMIM:

270150

Drugs & Therapeutics for Sjogren's Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Sjogren's Syndrome

Drug clinical trials:

Search ClinicalTrials for Sjogren's Syndrome

Search NIH Clinical Center for Sjogren's Syndrome

Search CenterWatch for Sjogren's Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Sjogren's Syndrome

Anatomical Context for Sjogren's Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Sjogren's Syndrome:

33
Skin, Liver, Brain, Kidney, Lung, Bone marrow, Pancreas, Thyroid, Salivary gland, Monocytes, T cells, B cells, Endothelial

Animal Models for Sjogren's Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Sjogren's Syndrome

Sources:
51PubMed
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Articles related to Sjogren's Syndrome:

(show top 50)    (show all 285)
idTitleAuthorsYear
1
Classification criteria for Sjogren's syndrome: nothing ever stands still! (24092418)
2014
2
Diagnostic accuracy of blood B-cell subset profiling and autoimmunity markers in Sjogren's syndrome. (24433480)
2014
3
Sjogren's syndrome and acquired splenic atrophy with septic shock: a case report. (24393211)
2014
4
EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) is sensitive to show efficacy of rituximab treatment in a randomised controlled trial. (23940214)
2014
5
Absence of somatic MYD88 L265P mutations in patients with primary Sjogren's syndrome. (24153350)
2014
6
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
7
Toxic epitheliopathy from a single application of preservative free oxybuprocaine (0.4%) in a patient with Sjogren's syndrome. (24038291)
2013
8
NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome. (23884468)
2013
9
Classification criteria for Sjogren's syndrome: we actually need to definitively resolve the long debate on the issue. (23264355)
2013
10
Activity of T-helper cells in patients with primary Sjogren's syndrome. (23422488)
2013
11
B-cell activating factor genetic variants in lymphomagenesis associated with primary Sjogren's syndrome. (23845207)
2013
12
Different stages of primary Sjogren's syndrome involving lymphotoxin and type 1 IFN. (23772034)
2013
13
Renal lymphoma: unusual lymphoproliferative manifestation of Sjogren's syndrome. (23280173)
2013
14
Health-related utility values of patients with primary Sjogren's syndrome and its predictors. (23761688)
2013
15
Primary presentation with acute flaccid quadriparesis in Sjogren's syndrome sans sicca. (23576645)
2013
16
Parkinsonism: An under-recognized neurological complication of Sjogren's syndrome. (24378066)
2013
17
Primary Sjogren's syndrome presenting as acute cerebellitis. (24055210)
2013
18
SIL1 mutations and clinical spectrum in patients with Marinesco-Sjogren syndrome. (24176978)
2013
19
Primary Sjogren's syndrome 1976-2005 and associated interstitial lung disease: a population-based study of incidence and mortality. (24282246)
2013
20
New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. (23846338)
2013
21
Prevalence of dry eye syndrome and Sjogren's syndrome in patients with rheumatoid arthritis. (22696854)
2012
22
Low copy number of the Fc-I^ receptor 3B gene FCGR3B is a risk factor for primary Sjogren's syndrome. (22942264)
2012
23
Sjogren-Larsson syndrome: A case report of a rare disease. (23130213)
2011
24
United Kingdom Primary Sjogren's Syndrome Registry--a united effort to tackle an orphan rheumatic disease. (20693261)
2011
25
Assessment of alveolar epithelial permeability with Tc-99m DTPA aerosol scintigraphy in patients with Sjogren syndrome. (19582462)
2010
26
Salivary epithelial cells from Sjogren's syndrome patients are highly sensitive to anoikis induced by TLR-3 ligation. (20685081)
2010
27
MUC1 expression in Sjogren's syndrome, KCS, and control subjects. (20806091)
2010
28
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
29
Interferon-gamma is increased in patients with primary Sjogren's syndrome and Raynaud's phenomenon. (18571695)
2009
30
Sensitive and robust luminescent profiling of anti-La and other autoantibodies in Sjogren's syndrome. (19657778)
2009
31
Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjogren's syndrome. (18089681)
2008
32
MUC16 expression in Sjogren's syndrome, KCS, and control subjects. (19122828)
2008
33
MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjogren syndrome patients. (18184611)
2008
34
Induction of anti-carbonic-anhydrase-II antibody causes renal tubular acidosis in a mouse model of Sjogren's syndrome. (17622741)
2007
35
Identification of parotid salivary biomarkers in Sjogren's syndrome by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry and two-dimensional difference gel electrophoresis. (16522680)
2006
36
Autoantibodies against carbonic anhydrase II are increased in renal tubular acidosis associated with Sjogren syndrome. (15694905)
2005
37
Osteomalacia revealing Sjogren's syndrome. (16226045)
2005
38
Analysis of in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome. (16192640)
2005
39
Antifodrin antibodies in Sjogren's syndrome: a review. (16126964)
2005
40
Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjogren's syndrome. (15593200)
2004
41
Liver involvement in primary Sjogren's syndrome]. (15678893)
2004
42
Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome. (15316122)
2004
43
Transverse myelitis occurring in association with primary biliary cirrhosis and Sjogren's syndrome. (12741480)
2003
44
Sjogren-Larsson syndrome. (11929038)
2002
45
Sjogren-Larsson syndrome: two cases with delayed diagnosis]. (12218895)
2002
46
Acute acalculous cholecystitis associated with systemic lupus erythematosus with Sjogren's syndrome. (12014215)
2002
47
Therapeutic effect of ethamsylate in a case of hyperglobulinemic purpura associated with Sjogren's syndrome. (8833011)
1996
48
Sjogren-Larsson syndrome. (8855639)
1996
49
Detection of Epstein-Barr virus antigens and DNA in major and minor salivary glands using immunocytochemistry and polymerase chain reaction: possible relationship with Sjogren's syndrome. (1851828)
1991
50
Granulocytopenia with marked lymphocytosis manifesting Sjogren syndrome. (7211836)
1980

Genetic Variations for Sjogren's Syndrome

Expression for genes affiliated with Sjogren's Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sjogren's Syndrome

Search GEO for disease gene expression data for Sjogren's Syndrome.

Pathways for genes affiliated with Sjogren's Syndrome

Compounds for genes affiliated with Sjogren's Syndrome

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Sjogren's Syndrome according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1glutamate4511.3HSPG2, ICA1, APOH, LTF, CD79A, SPTAN1
2phosphatidylserine45 29 1113.2RNPC3, CD79A, LTF, APOH, HSPG2
3creatinine4511.2LCN1, TNFSF13B, APOH, LTF, CD79A
4phosphatidylcholine4511.1HSPG2, APOH, LTF, CD79A
5vitamin b124511.0CD79A, LTF, APOH
6betacarotene4511.0LCN1, APOH, CD79A
7rituximab45 50 1113.0CD79A, APOH, TNFSF13B
8hypothiocyanite45 2411.9CD79A, LTF
9gluten4510.9APOH, CD79A
10lactulose4510.8CD79A, LTF
11thiocyanate45 2411.8LTF, CD79A
12pneumococcal4510.8LTF, CD79A
13azathioprine45 50 2 1113.7CD79A, LTF, APOH
14sialic acid4510.7CD79A, LTF, APOH
15blys4510.7CD79A, TNFSF13B
16piroxicam45 1111.6HSPG2, CD79A
17pilocarpine45 29 1112.4HSPG2, CD79A

GO Terms for genes affiliated with Sjogren's Syndrome

Sources:
16Gene Ontology
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Cellular components related to Sjogren's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonucleoprotein complexGO:03052910.7TRIM21, TROVE2, SSB

Products for genes affiliated with Sjogren's Syndrome

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  • Proteins
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Sources for Sjogren's Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet