MCID: SJG001
MIFTS: 52

Sjogren's Syndrome malady

Summaries for Sjogren's Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Sjogren's syndrome is a disease that causes dryness in your mouth and eyes. it can also lead to dryness in other places that need moisture, such as your nose, throat and skin. most people who get sjogren's syndrome are older than 40. nine of 10 are women. sjogren's syndrome is sometimes linked to rheumatic problems such as rheumatoid arthritis. sjogren's syndrome is an autoimmune disease. if you have an autoimmune disease, your immune system, which is supposed to fight disease, mistakenly attacks parts of your own body. in sjogren's syndrome, your immune system attacks the glands that make tears and saliva. it may also affect your joints, lungs, kidneys, blood vessels, digestive organs and nerves. the main symptoms are: dry eyes dry mouth treatment focuses on relieving symptoms. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Sjogren's Syndrome, also known as sicca syndrome, is related to uveitis and erythema multiforme. An important gene associated with Sjogren's Syndrome is TRIM21 (tripartite motif containing 21). The drug linolenic acid and the compounds glutamate and phosphatidylserine have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and kidney.

Disease Ontology:8 An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.

Genetics Home Reference:21 Sjögren syndrome is a disorder whose main features are dry eyes and a dry mouth. The condition typically develops gradually beginning in middle adulthood, but can occur at any age.

NIH Rare Diseases:42 Sjögren syndrome is an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis. the hallmark symptoms of the disorder are dry mouth and dry eyes. in addition, sjogren syndrome may cause skin, nose, and vaginal dryness, and may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain. treatment is symptomatic and supportive and may include moisture replacement therapies, nonsteroidal anti-inflammatory drugs and, in severe cases, corticosteroids or immunosuppressive drugs. last updated: 5/2/2012

NINDS:43 Sj

Wikipedia:63 Sjögren\'s syndrome (pronounced /ˈʃoʊɡrɨn/ SHOH-grin or /ˈʃʌrɡrɨn/ SHUR-grin in... more...

Description from OMIM:46 270150

Aliases & Classifications for Sjogren's Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 46OMIM, 27ICD9CM
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Aliases & Descriptions:

sjogren's syndrome 8 21 33 60
sicca syndrome 8 42 21 60
sjogren-gougerot syndrome 42 21
sjogrens syndrome 10 44
keratoconjunctivitis sicca-xerostomia 21
secreto-inhibitor-xerodermostenosis 21
dacryosialoadenopathia atrophicans 21
gougerot-houwer-sjogren syndrome 21
keratoconjunctivitis sicca 21
gougerot-sjogren syndrome 21
sjögren's syndrome 43
sjögren syndrome 21
sjogren syndrome 42
xerodermosteosis 8


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Disease Ontology8 DOID:12894
NCIt39 C70647
MeSH34 D012859
OMIM46 270150
ICD9CM27 710.2

Related Diseases for Sjogren's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Sjogren's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.4RNPC3
2erythema multiforme30.4HSPG2
3lupus erythematosus30.1APOH, CD79A, TRIM21, TROVE2
4keratoconjunctivitis sicca30.1LTF, HSPG2
5myopathy30.1SIL1
6systemic lupus erythematosus30.1TNFSF13B
7rheumatoid arthritis29.9HSPG2, TRIM21, LTF, RNPC3, CD79A, SPTAN1
8vasculitis29.9TRIM21, APOH, CD79A, TNFSF13B, LTF
9systemic scleroderma29.9RNPC3, APOH, TNFSF13B, HSPG2, SSB
10connective tissue disease29.9APOH, RNPC3, HSPG2, LTF
11primary biliary cirrhosis29.9RNPC3, HSPG2, LTF, CD79A
12mixed connective tissue disease29.9HSPG2, RNPC3, APOH
13dry eye syndrome29.9HSPG2, LTF
14sialadenitis29.9HSPG2
15hepatitis c29.9RNPC3, HSPG2
16purpura29.9HSPG2, CD79A
17hepatitis29.9HSPG2
18arthritis29.9LTF
19marinesco-sjögren syndrome10.6
20corneal ulcer10.4
21graft versus host disease10.3
22corneal disease10.3
23rosacea10.3
24achalasia10.3
25dacryoadenitis10.3
26ectropion10.3
27esophagitis10.3
28keratoconus10.3
29sarcoidosis10.3
30cataract10.2
31bone fracture10.1
32cutaneous lupus erythematosus10.1
33ocular albinism10.1
34acute dacryocystitis10.1
35juvenile rheumatoid arthritis10.1
36chromosomal disease10.1
37collagen disease10.1
38conjunctivitis10.1
39dacryocystitis10.1
40diabetes mellitus10.1
41diabetic retinopathy10.1
42hypothyroidism10.1
43keratitis10.1
44lagophthalmos10.1
45lens disease10.1
46leprosy10.1
47otitis media10.1
48peritonitis10.1
49pleurisy10.1
50pneumonia10.1

Graphical network of the top 20 diseases related to Sjogren's Syndrome:



Diseases related to sjogren's syndrome

Clinical Features for Sjogren's Syndrome

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46OMIM
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Clinical features from OMIM:

270150

Drugs & Therapeutics for Sjogren's Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Sjogren's Syndrome

Drug clinical trials:

Search ClinicalTrials for Sjogren's Syndrome

Search NIH Clinical Center for Sjogren's Syndrome

Search CenterWatch for Sjogren's Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Sjogren's Syndrome

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Anatomical Context for Sjogren's Syndrome

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32MalaCards
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MalaCards organs/tissues related to Sjogren's Syndrome:

32
Eye, Lung, Kidney, Skin, Salivary gland, Liver, Brain, Pancreas, T cells, B cells, Thyroid, Monocytes, Testes, Bone, Endothelial, Bone marrow

Animal Models for Sjogren's Syndrome or affiliated genes

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Publications for Sjogren's Syndrome

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50PubMed
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Articles related to Sjogren's Syndrome:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Potential involvement of the IL-33-ST2 axis in the pathogenesis of primary Sjogren's syndrome. (24385203)
2014
2
Meta-analysis of differentially expressed genes in primary Sjogren's syndrome by using microarray. (24090683)
2014
3
The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. (24307005)
2013
4
Sjogren's syndrome with trigeminal neuropathy: motor involvement. (23703941)
2013
5
Rituximab modulates the expression of IL-22 in the salivary glands of patients with primary Sjogren's syndrome. (23264342)
2013
6
NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome. (23884468)
2013
7
Classification criteria for Sjogren's syndrome: we actually need to definitively resolve the long debate on the issue. (23264355)
2013
8
Activity of T-helper cells in patients with primary Sjogren's syndrome. (23422488)
2013
9
Genetic associations to germinal centre formation in primary Sjogren's syndrome. (23606706)
2013
10
Health-related utility values of patients with primary Sjogren's syndrome and its predictors. (23761688)
2013
11
Prevalence of interferon type I signature in CD14 monocytes of patients with Sjogren's syndrome and association with disease activity and BAFF gene expression. (22736090)
2013
12
Serum levels of BAFF, but not APRIL, are increased after rituximab treatment in patients with primary Sjogren's syndrome: data from a placebo-controlled clinical trial. (22851468)
2013
13
Prevalence of oral lesions of autoimmune etiology in patients with primary Sjogren's syndrome. (23279206)
2013
14
Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome. (23709238)
2013
15
Updates on B-cell immunotherapies for systemic lupus erythematosus and Sjogren's syndrome. (22871954)
2012
16
STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. (22904194)
2012
17
Endocrine alterations in primary Sjogren's syndrome: an overview. (22695186)
2012
18
Unusual presentation of a case of Sjogren's syndrome with neurological and ocular manifestation. (22098691)
2012
19
The salivary gland epithelial cell in Sjogren's Syndrome: what are the steps involved in wounding or killing their secretory function? (22661415)
2012
20
The distinct pathogenesis of IgG4 Mickulicz's disease and Sjogren's syndrome in Japan; the role of IL-21 and IL-6. (23124830)
2012
21
Periodic fever as the manifestation of primary Sjogren's syndrome: a case report and literature review. (22837018)
2012
22
Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis. (22208651)
2012
23
Increased interleukin (IL)-7RI+ expression in salivary glands of patients with primary Sjogren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity. (22312161)
2012
24
Recurrent parotitis as a first manifestation in a child with primary Sjogren's syndrome. (22512231)
2011
25
Clinical efficacy of the SmartPluga8c in the treatment of primary Sjogren's syndrome with keratoconjunctivitis sicca: one-year follow-up study. (20490802)
2011
26
Prosthodontic Rehabilitation in Sjogren's Syndrome with a Simplified Palatal Reservoir: Two Year Follow Up. (22131673)
2010
27
Autoantibody and biopsy grading are associated with expression of ICAM-1, MMP-3, and TRAIL in salivary gland mononuclear cells of Chinese patients with Sjogren's syndrome. (19332626)
2009
28
Treatment of sicca symptoms with hydroxychloroquine in patients with Sjogren's syndrome. (19433433)
2009
29
Central nervous system lymphoma in a patient with Sjogren's syndrome and autoimmune thyroiditis (Hashimoto's thyroiditis). (16941199)
2007
30
Systemic lupus erythematosus presenting as parotitis and secondary Sjogren's syndrome. (17304382)
2007
31
Endothelial nitric oxide synthase +894 polymorphism is associated with recurrent salivary gland swelling and early onset in patients with primary Sjogren's syndrome. (17881665)
2007
32
Characterization of T-cell large granular lymphocyte leukemia associated with Sjogren's syndrome-an important but under-recognized association. (16616153)
2006
33
A case of systemic sclerosis and Sjogren's syndrome with cardiac tamponade due to steroid-responsive pericarditis]. (16883110)
2006
34
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death. (16670339)
2006
35
A peptide of human muscarinic acetylcholine receptor 3 is antigenic in primary Sjogren's syndrome. (15725576)
2005
36
Osteomalacia revealing Sjogren's syndrome. (16226045)
2005
37
Molecular mechanisms of salivary gland destruction in patients with Sjogren's syndrome. ]. (15744117)
2005
38
Analysis of in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome. (16192640)
2005
39
Minor gland saliva flow rate and proteins in subjects with hyposalivation due to Sjogren's syndrome and radiation therapy. (15740707)
2005
40
Sinus histocytosis with massive lymphadenopathy (Rosai-Dorfman disease) in a patient with primary Sjogren's syndrome. (15163114)
2004
41
Putative anti-muscarinic antibodies cannot be detected in patients with primary Sjogren's syndrome using conventional immunological approaches. (15353609)
2004
42
Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome. (15316122)
2004
43
Acute acalculous cholecystitis associated with systemic lupus erythematosus with Sjogren's syndrome. (12014215)
2002
44
Prophylactic antibiotics in recurrent parotitis in a patient with Sjogren's syndrome. (10357124)
1999
45
Indicators of salivary gland inflammation in primary Sjogren's syndrome. (9249189)
1997
46
Distinct alterations in lineage committed progenitor cells exist in the peripheral blood of patients with rheumatoid arthritis and primary Sjogren's syndrome. (8832979)
1996
47
Therapeutic effect of ethamsylate in a case of hyperglobulinemic purpura associated with Sjogren's syndrome. (8833011)
1996
48
Possible etiological relations between Sjogren's syndrome and Epstein-Barr virus]. (1648423)
1991
49
Primary biliary cirrhosis, Sjogren's syndrome, and transverse myelitis. (3940247)
1986
50
The parotid gland in Mikulicz disease and Sjogren's syndrome. (13713215)
1960

Genetic Variations for Sjogren's Syndrome

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Expression for genes affiliated with Sjogren's Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sjogren's Syndrome

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Pathways for genes affiliated with Sjogren's Syndrome

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Compounds for genes affiliated with Sjogren's Syndrome

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Sjogren's Syndrome according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1glutamate4411.3HSPG2, ICA1, APOH, LTF, CD79A, SPTAN1
2phosphatidylserine44 28 1113.2RNPC3, CD79A, LTF, APOH, HSPG2
3creatinine4411.2LCN1, TNFSF13B, APOH, LTF, CD79A
4phosphatidylcholine4411.1HSPG2, APOH, LTF, CD79A
5vitamin b124411.0CD79A, LTF, APOH
6betacarotene4411.0LCN1, APOH, CD79A
7rituximab44 49 1113.0CD79A, APOH, TNFSF13B
8hypothiocyanite44 2411.9CD79A, LTF
9gluten4410.9APOH, CD79A
10lactulose4410.8CD79A, LTF
11thiocyanate44 2411.8LTF, CD79A
12pneumococcal4410.8LTF, CD79A
13azathioprine44 49 2 1113.7CD79A, LTF, APOH
14sialic acid4410.7CD79A, LTF, APOH
15blys4410.7CD79A, TNFSF13B
16piroxicam44 1111.6HSPG2, CD79A
17pilocarpine44 28 1112.4HSPG2, CD79A

GO Terms for genes affiliated with Sjogren's Syndrome

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16Gene Ontology
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Cellular components related to Sjogren's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonucleoprotein complexGO:03052910.7TRIM21, TROVE2, SSB

Products for genes affiliated with Sjogren's Syndrome

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Sources for Sjogren's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet