MCID: SJG001
MIFTS: 44

Sjogren's Syndrome malady

Rare diseases, Immune diseases categories

Summaries for Sjogren's Syndrome

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9Disease Ontology, 44NIH Rare Diseases, 35MedlinePlus, 45NINDS, 22Genetics Home Reference, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Sjogren's syndrome is a disease that causes dryness in your mouth and eyes. it can also lead to dryness in other places that need moisture, such as your nose, throat and skin. most people who get sjogren's syndrome are older than 40. nine of 10 are women. sjogren's syndrome is sometimes linked to rheumatic problems such as rheumatoid arthritis. sjogren's syndrome is an autoimmune disease. if you have an autoimmune disease, your immune system, which is supposed to fight disease, mistakenly attacks parts of your own body. in sjogren's syndrome, your immune system attacks the glands that make tears and saliva. it may also affect your joints, lungs, kidneys, blood vessels, digestive organs and nerves. the main symptoms are: dry eyes dry mouth treatment focuses on relieving symptoms. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Sjogren's Syndrome, also known as sicca syndrome, is related to lupus erythematosus and rheumatic disease. An important gene associated with Sjogren's Syndrome is SIL1 (SIL1 nucleotide exchange factor), and among its related pathways is RNA Polymerase I Promoter Opening. The drug linolenic acid has been mentioned in the context of this disorder. Affiliated tissues include eye, lung and skin.

Disease Ontology:9 A hypersensitivity reaction type ii disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.

NIH Rare Diseases:44 Sjƶgren syndrome is an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. sjƶgren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis. the hallmark symptoms of the disorder are dry mouth and dry eyes. in addition, sjogren syndrome may cause skin, nose, and vaginal dryness, and may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain. treatment is symptomatic and supportive and may include moisture replacement therapies, nonsteroidal anti-inflammatory drugs and, in severe cases, corticosteroids or immunosuppressive drugs. last updated: 5/2/2012

NINDS:45 Sj

Genetics Home Reference:22 Sjƶgren syndrome is a disorder whose main features are dry eyes and a dry mouth. The condition typically develops gradually beginning in middle adulthood, but can occur at any age.

Wikipedia:66 Sj more...

Description from OMIM:48 270150

Aliases & Classifications for Sjogren's Syndrome

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22Genetics Home Reference, 9Disease Ontology, 35MedlinePlus, 63UMLS, 44NIH Rare Diseases, 45NINDS, 11DISEASES, 46Novoseek, 48OMIM, 36MeSH, 59SNOMED-CT, 41NCIt, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Aliases & Descriptions:

sjogren's syndrome 9 22 35 63
sicca syndrome 9 44 22 63
sjogren-gougerot syndrome 44 22
sjogrens syndrome 11 46
sjogren syndrome 9 44
keratoconjunctivitis sicca-xerostomia 22
secreto-inhibitor-xerodermostenosis 22
dacryosialoadenopathia atrophicans 22
gougerot-houwer-sjogren syndrome 22
keratoconjunctivitis sicca 22
gougerot-sjogren syndrome 22
sjƶgren's syndrome 45
sjƶgren syndrome 22
xerodermosteosis 9


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Disease Ontology9 DOID:12894
OMIM48 270150
MeSH36 D012859
NCIt41 C70647
ICD9CM28 710.2

Related Diseases for Sjogren's Syndrome

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Sjogren's Syndrome:



Diseases related to sjogren's syndrome

Symptoms for Sjogren's Syndrome

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48OMIM
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Clinical features from OMIM:

270150

Drugs & Therapeutics for Sjogren's Syndrome

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Sjogren's Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Sjogren's Syndrome

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Anatomical Context for Sjogren's Syndrome

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34MalaCards
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MalaCards organs/tissues related to Sjogren's Syndrome:

34
Eye, Lung, Skin, Kidney, Salivary gland, Liver, Pancreas, Brain, T cells, B cells, Thyroid, Bone, Testes, Monocytes, Bone marrow, Endothelial

Animal Models for Sjogren's Syndrome or affiliated genes

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Publications for Sjogren's Syndrome

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53PubMed
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Articles related to Sjogren's Syndrome:

(show top 50)    (show all 232)
idTitleAuthorsYear
1
Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. (23968620)
2014
2
Classification criteria for Sjogren's syndrome: nothing ever stands still! (24092418)
2014
3
Annular subacute cutaneous lupus erythematosus lesions and polymyositis onset in a patient with primary Sjogren's syndrome: how should this unusual association be classified? (23358869)
2013
4
The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. (24307005)
2013
5
Hypokalemic rhabdomyolysis: an unusual presentation of Sjogren's syndrome. (24165505)
2013
6
Polymicrobial and microsporidial keratitis in a patient using Boston scleral contact lens for Sjogren's syndrome and ocular cicatricial pemphigoid. (23123433)
2013
7
Sjogren's syndrome with acute cerebellar ataxia and massive lymphadenopathy : a case report. (24030041)
2013
8
Sjogren's syndrome with trigeminal neuropathy: motor involvement. (23703941)
2013
9
Toxic epitheliopathy from a single application of preservative free oxybuprocaine (0.4%) in a patient with Sjogren's syndrome. (24038291)
2013
10
High prevalence of autoimmune thyroid disease in subjects with sicca symptoms without Sjogren's syndrome. (23382358)
2013
11
The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome. (24080911)
2013
12
Effects of total glucosides of paeony for delaying onset of Sjogren's syndrome: an animal study. (23333492)
2013
13
Autoantibodies and Sjogren's Syndrome in multiple sclerosis, a reappraisal. (23776474)
2013
14
Severe excessive dynamic airway collapse in a patient with primary Sjogren's syndrome. (24381188)
2013
15
Efficacy and safety of belimumab in primary Sjogren's syndrome: results of the BELISS open-label phase II study. (24347569)
2013
16
Rituximab modulates the expression of IL-22 in the salivary glands of patients with primary Sjogren's syndrome. (23264342)
2013
17
NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome. (23884468)
2013
18
Lymphocytic interstitial pneumonia as a manifestation of SLE and secondary Sjogren's syndrome. (23912652)
2013
19
Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren's syndrome. (24093879)
2013
20
Prevalence and predictors of Sjogren's syndrome in a prospective cohort of patients with aqueous-deficient dry eye. (23001257)
2012
21
Sialochemistry and cortisol levels in patients with Sjogren's syndrome. (22050355)
2012
22
Updates on B-cell immunotherapies for systemic lupus erythematosus and Sjogren's syndrome. (22871954)
2012
23
Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjogren's syndrome. (21558290)
2012
24
Genetic association between methyl-CpG binding protein 2 (MECP2) and primary Sjogren's syndrome. (20215141)
2010
25
The numbers of Foxp3 + Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren's syndrome. (19952070)
2010
26
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. (20007286)
2010
27
Nodular regenerative hyperplasia of the liver, celiac disease and Sjogren's syndrome in a child. (19765928)
2010
28
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci. (19218603)
2009
29
Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome. (19181658)
2009
30
Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome. (19833746)
2009
31
Effects of oral consumption of the green tea polyphenol EGCG in a murine model for human Sjogren's syndrome, an autoimmune disease. (18809413)
2008
32
Central nervous system lymphoma in a patient with Sjogren's syndrome and autoimmune thyroiditis (Hashimoto's thyroiditis). (16941199)
2007
33
Successful treatment of refractory anterior scleritis in primary Sjogren's syndrome with rituximab. (15958765)
2005
34
Prevalence of IgG anti-{alpha}-fodrin antibodies in Sjogren's syndrome. (16014536)
2005
35
A peptide of human muscarinic acetylcholine receptor 3 is antigenic in primary Sjogren's syndrome. (15725576)
2005
36
Osteomalacia revealing Sjogren's syndrome. (16226045)
2005
37
Changes in salivary gland immunohistology and function after rituximab monotherapy in a patient with Sjogren's syndrome and associated MALT lymphoma. (15576414)
2005
38
Presence of apolipoprotein E epsilon4 allele predisposes to early onset of primary Sjogren's syndrome. (15328426)
2004
39
Sinus histocytosis with massive lymphadenopathy (Rosai-Dorfman disease) in a patient with primary Sjogren's syndrome. (15163114)
2004
40
Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjogren's syndrome. (15593200)
2004
41
Normalization of anticardiolipin antibodies following rituximab therapy for marginal zone lymphoma in a patient with Sjogren's syndrome. (15448217)
2004
42
Transverse myelitis occurring in association with primary biliary cirrhosis and Sjogren's syndrome. (12741480)
2003
43
Prophylactic antibiotics in recurrent parotitis in a patient with Sjogren's syndrome. (10357124)
1999
44
Amidolytic and peptidolytic activities of immunoglobulin G present in sera from patients with rheumatoid arthritis, Sjogren's syndrome and systemic lupus erythematosus. (9767453)
1998
45
Distinct alterations in lineage committed progenitor cells exist in the peripheral blood of patients with rheumatoid arthritis and primary Sjogren's syndrome. (8832979)
1996
46
Therapeutic effect of ethamsylate in a case of hyperglobulinemic purpura associated with Sjogren's syndrome. (8833011)
1996
47
Detection of cytomegalovirus and Epstein-Barr virus in labial salivary glands in Sjogren's syndrome and non-specific sialadenitis. (7473264)
1995
48
Detection of Epstein-Barr virus antigens and DNA in major and minor salivary glands using immunocytochemistry and polymerase chain reaction: possible relationship with Sjogren's syndrome. (1851828)
1991
49
Sjogren's syndrome and keratoconjunctivitis sicca. (2055025)
1991
50
Hashimoto's thyroiditis, pernicious anemia, Sjogren's syndrome, and CRST syndrome -- a case report. (6894462)
1981

Variations for Sjogren's Syndrome

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Expression for genes affiliated with Sjogren's Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Sjogren's Syndrome

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Pathways for genes affiliated with Sjogren's Syndrome

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51PathCards, 56Reactome, 31KEGG
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Compounds for genes affiliated with Sjogren's Syndrome

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GO Terms for genes affiliated with Sjogren's Syndrome

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17Gene Ontology
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Cellular components related to Sjogren's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ribonucleoprotein complexGO:0305299.5TROVE2, TRIM21, SSB

Products for genes affiliated with Sjogren's Syndrome

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Sources for Sjogren's Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet