MCID: SKL003
MIFTS: 35

Skeletal Muscle Cancer

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Skeletal Muscle Cancer

MalaCards integrated aliases for Skeletal Muscle Cancer:

Name: Skeletal Muscle Cancer 12 14
Skeletal Muscle Neoplasm 12 14 69
Malignant Tumor of Skeletal Muscle 12
Tumor of Skeletal Muscle 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4043 DOID:4044
NCIt 46 C6516 C6514
SNOMED-CT 64 699955004

Summaries for Skeletal Muscle Cancer

MalaCards based summary : Skeletal Muscle Cancer, also known as skeletal muscle neoplasm, is related to rhabdomyosarcoma and muscle cancer. An important gene associated with Skeletal Muscle Cancer is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. Affiliated tissues include skeletal muscle, and related phenotypes are growth/size/body region and cellular

Related Diseases for Skeletal Muscle Cancer

Diseases related to Skeletal Muscle Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 29.2 CDK4 FOXO1 IGF1R IGF2 MB MYF5
2 muscle cancer 27.1 FOXO1 IGF2 KIDINS220 MB MYF5 MYOD1
3 malignant triton tumor 10.4 MB MYOD1
4 meninges sarcoma 10.4 IGF2 MB
5 mesenchymoma 10.3 MB MYOD1
6 orbit rhabdomyosarcoma 10.3 MB MYOG
7 spindle cell lipoma 10.3 CDK4 FOXO1
8 gallbladder sarcoma 10.3 MYOD1 MYOG
9 breast rhabdomyosarcoma 10.3 MB MYOD1 MYOG
10 histiocytoma 10.2 CDK4 MB MYOD1
11 adult fibrosarcoma 10.2 MB MYOD1 MYOG
12 spindle cell rhabdomyosarcoma 10.2 MB MYOD1
13 rhabdoid cancer 10.2 IGF1R IGF2 MB MYOD1
14 medullomyoblastoma 10.2 MB MYOD1 MYOG
15 muscular dystrophy, congenital, lmna-related 10.2 MEF2A MEF2C MYOD1
16 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MYOD1 MYOG
17 spindle cell liposarcoma 10.2 CDK4 MYOD1 MYOG
18 embryonal sarcoma 10.1 CDK4 MYOD1 MYOG
19 central nervous system mesenchymal non-meningothelial tumor 10.1 FOXO1 MYF6 MYOD1 PAX3 PAX7
20 pleomorphic rhabdomyosarcoma 10.1 FOXO1 MB MYOD1 PAX3 PAX7
21 hemophagocytic lymphohistiocytosis, familial, 1 10.1 MYF6 MYOD1
22 leiomyosarcoma 10.0 CDK4 IGF2 MB MYOG
23 childhood kidney cell carcinoma 9.9 FOXO1 PAX3 TFE3
24 alveolar soft part sarcoma 9.8 MB MYF6 MYOD1 TFE3
25 malignant mesenchymoma 9.8 CDK4 CDKN1A MB MYOD1 MYOG
26 inflammatory leiomyosarcoma 9.7 MYF5 MYF6 MYOD1 MYOG PAX7
27 conventional leiomyosarcoma 9.7 MYF5 MYF6 MYOD1 MYOG PAX7
28 ewing sarcoma 9.7 FOXO1 IGF1R IGF2 MYOD1 MYOG PAX3
29 radin blood group antigen 9.7
30 breast cancer 9.7
31 cervical cancer 9.7
32 cervicitis 9.7
33 lipomatosis, multiple 9.7
34 extraosseous ewing's sarcoma 9.7 KIDINS220 MYF5 MYF6 MYOD1 MYOG
35 botryoid rhabdomyosarcoma 9.6 FOXO1 MB MYF5 MYOD1 MYOG PAX3
36 waardenburg's syndrome 9.5 MYF5 PAX3 TFE3
37 embryonal rhabdomyosarcoma 9.4 CDK4 FOXO1 IGF2 MB MYOD1 MYOG
38 rhabdomyosarcoma 2 9.4 CDK4 FOXO1 IGF1R MB MYOD1 MYOG

Graphical network of the top 20 diseases related to Skeletal Muscle Cancer:



Diseases related to Skeletal Muscle Cancer

Symptoms & Phenotypes for Skeletal Muscle Cancer

MGI Mouse Phenotypes related to Skeletal Muscle Cancer:

43 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.49 CDK4 FOXO1 CDKN1A IGF1R KIDINS220 IGF2
2 cellular MP:0005384 10.45 CDK4 FOXO1 CDKN1A IGF1R JDP2 KIDINS220
3 cardiovascular system MP:0005385 10.4 CDK4 FOXO1 CDKN1A IGF1R KIDINS220 IGF2
4 homeostasis/metabolism MP:0005376 10.39 CDK4 FOXO1 CDKN1A IGF1R JDP2 IGF2
5 mortality/aging MP:0010768 10.39 CDK4 FOXO1 CDKN1A IGF1R KIDINS220 IGF2
6 behavior/neurological MP:0005386 10.37 CDKN1A CDK4 FOXO1 IGF2 IGF1R MYF5
7 embryo MP:0005380 10.36 CDK4 FOXO1 CDKN1A IGF1R IGF2 MB
8 muscle MP:0005369 10.31 CDK4 FOXO1 CDKN1A IGF1R IGF2 MB
9 hematopoietic system MP:0005397 10.3 CDKN1A CDK4 FOXO1 IGF2 IGF1R JDP2
10 immune system MP:0005387 10.24 CDKN1A CDK4 FOXO1 IGF2 JDP2 IGF1R
11 craniofacial MP:0005382 10.22 FOXO1 CDKN1A IGF1R IGF2 MYF5 MEF2C
12 adipose tissue MP:0005375 10.2 CDKN1A FOXO1 IGF1R JDP2 MYF5 MYF6
13 integument MP:0010771 10.18 CDKN1A CDK4 FOXO1 IGF1R JDP2 IGF2
14 digestive/alimentary MP:0005381 10.1 CDKN1A CDK4 FOXO1 IGF2 IGF1R PAX3
15 normal MP:0002873 10.07 CDK4 FOXO1 JDP2 MYF5 MEF2A MEF2C
16 limbs/digits/tail MP:0005371 10.06 CDKN1A FOXO1 IGF2 IGF1R JDP2 MEF2C
17 neoplasm MP:0002006 10.02 CDK4 FOXO1 CDKN1A IGF1R MYF5 MYF6
18 no phenotypic analysis MP:0003012 10.02 FOXO1 CDKN1A KIDINS220 IGF2 MYF5 MYF6
19 respiratory system MP:0005388 9.97 CDKN1A IGF1R IGF2 MB MEF2A MEF2C
20 skeleton MP:0005390 9.8 FOXO1 CDKN1A IGF1R JDP2 IGF2 MEF2C
21 vision/eye MP:0005391 9.28 CDKN1A CDK4 IGF2 KIDINS220 MYF5 MYF6

Drugs & Therapeutics for Skeletal Muscle Cancer

Search Clinical Trials , NIH Clinical Center for Skeletal Muscle Cancer

Genetic Tests for Skeletal Muscle Cancer

Anatomical Context for Skeletal Muscle Cancer

MalaCards organs/tissues related to Skeletal Muscle Cancer:

38
Skeletal Muscle

Publications for Skeletal Muscle Cancer

Articles related to Skeletal Muscle Cancer:

# Title Authors Year
1
Cytotoxicity Studies of the Extracts, Fractions, and Isolated Compound of Pseudocedrela kotschyi on Cervical Cancer (HeLa), Breast Cancer (MCF-7) and Skeletal Muscle Cancer (RD) Cells. ( 28250653 )
2017
2
Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. ( 20193046 )
2010

Variations for Skeletal Muscle Cancer

Expression for Skeletal Muscle Cancer

Search GEO for disease gene expression data for Skeletal Muscle Cancer.

Pathways for Skeletal Muscle Cancer

Pathways related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 CDK4 FOXO1 MEF2A MEF2C MYF5 MYF6
2 12.68 CDK4 CDKN1A FOXO1 IGF1R IGF2
3
Show member pathways
12.63 IGF1R IGF2 MEF2A MEF2C
4 12.14 CDKN1A FOXO1 IGF1R MEF2C PAX3 PAX7
5
Show member pathways
12.07 CDK4 CDKN1A FOXO1 IGF1R
6 11.88 CDKN1A FOXO1 MEF2A MEF2C
7 11.85 CDK4 CDKN1A FOXO1 IGF1R IGF2
8 11.83 MEF2C MYF5 MYOD1 MYOG PAX3 PAX7
9 11.76 PAX3 PAX7 TFAP2B
10 11.73 FOXO1 MEF2C MYOD1
11 11.6 CDKN1A MYF6 MYOD1
12 11.52 CDK4 CDKN1A FOXO1 MEF2C MYOD1 TFE3
13 11.5 IGF1R IGF2 MEF2C
14 11.48 CDKN1A MEF2C MYOD1 PAX3
15
Show member pathways
11.37 CDKN1A IGF1R IGF2 MEF2A MEF2C MYF6
16 11.26 CDKN1A FOXO1 MYOD1
17 11.23 MEF2A MEF2C MYOD1
18 11.21 MEF2A MEF2C MYF5 MYOD1 PAX7
19
Show member pathways
11.2 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
20 10.66 MEF2A MEF2C

GO Terms for Skeletal Muscle Cancer

Cellular components related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.83 CDK4 CDKN1A FOXO1 JDP2 MEF2A MEF2C
2 transcription factor complex GO:0005667 9.46 CDK4 MEF2A MYOD1 MYOG
3 nucleoplasm GO:0005654 9.4 CDK4 CDKN1A FOXO1 MEF2A MEF2C MYF5
4 cyclin-dependent protein kinase holoenzyme complex GO:0000307 9.26 CDK4 CDKN1A

Biological processes related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 skeletal muscle cell differentiation GO:0035914 9.83 MEF2C MYF5 MYF6 MYOD1 MYOG
2 skeletal muscle tissue regeneration GO:0043403 9.81 MYF6 MYOG NACA PAX7
3 positive regulation of myoblast fusion GO:1901741 9.8 MYF5 MYF6 MYOD1 MYOG
4 ossification GO:0001503 9.79 IGF2 MYF5 MYOG
5 insulin receptor signaling pathway GO:0008286 9.77 FOXO1 IGF1R IGF2
6 myotube differentiation GO:0014902 9.74 MEF2C MYOD1 MYOG
7 muscle tissue morphogenesis GO:0060415 9.71 MYF5 MYF6 PAX7
8 positive regulation of skeletal muscle fiber development GO:0048743 9.67 MYF5 MYF6 MYOD1 MYOG
9 positive regulation of myoblast differentiation GO:0045663 9.65 MEF2C MYF5 MYF6 MYOD1 MYOG
10 skeletal muscle tissue development GO:0007519 9.63 MEF2C MYF5 MYF6 MYOD1 MYOG PAX7
11 response to hyperoxia GO:0055093 9.62 CDK4 CDKN1A
12 muscle cell fate commitment GO:0042693 9.62 MYF5 MYF6 MYOD1 MYOG
13 positive regulation of muscle cell differentiation GO:0051149 9.43 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
14 muscle organ development GO:0007517 9.23 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
15 transcription, DNA-templated GO:0006351 10.34 FOXO1 JDP2 MEF2A MEF2C MYF5 MYOD1
16 regulation of transcription, DNA-templated GO:0006355 10.32 FOXO1 IGF2 JDP2 MEF2A MEF2C MYF5
17 multicellular organism development GO:0007275 10.22 CDK4 IGF2 MEF2A MEF2C MYF5 MYF6
18 transcription by RNA polymerase II GO:0006366 10.15 MEF2A MEF2C MYF5 MYF6 MYOD1 PAX3
19 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 FOXO1 MEF2A MEF2C MYF5 MYF6 MYOD1
20 cell differentiation GO:0030154 10.13 FOXO1 MEF2A MEF2C MYF5 MYF6 MYOD1
21 positive regulation of transcription, DNA-templated GO:0045893 10.11 FOXO1 MEF2A MEF2C MYF6 MYOD1 MYOG
22 negative regulation of transcription by RNA polymerase II GO:0000122 10.07 FOXO1 IGF2 JDP2 MEF2A MEF2C TFAP2B
23 regulation of transcription by RNA polymerase II GO:0006357 10.05 CDKN1A FOXO1 JDP2 MYF5 MYF6 MYOD1
24 negative regulation of apoptotic process GO:0043066 10 CDKN1A FOXO1 IGF1R PAX7 TFAP2B

Molecular functions related to Skeletal Muscle Cancer according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.97 JDP2 MEF2A MEF2C MYF5 MYF6 MYOD1
2 sequence-specific DNA binding GO:0043565 9.97 FOXO1 MEF2A MEF2C MYF5 MYOD1 MYOG
3 chromatin binding GO:0003682 9.95 FOXO1 JDP2 MEF2A MEF2C MYOD1 TFAP2B
4 DNA binding transcription factor activity GO:0003700 9.9 FOXO1 JDP2 MEF2A MEF2C MYF6 MYOD1
5 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.89 MEF2A MEF2C MYOG TFAP2B TFE3
6 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.86 JDP2 MEF2A MEF2C MYF5 MYF6 MYOD1
7 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.84 MEF2A MEF2C MYOD1 MYOG
8 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.83 FOXO1 MEF2A MEF2C TFAP2B
9 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.81 MYF5 MYF6 MYOD1 MYOG
10 E-box binding GO:0070888 9.73 MYF5 MYF6 MYOD1 MYOG
11 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding GO:0000983 9.63 MEF2C PAX7 TFAP2B
12 HMG box domain binding GO:0071837 9.55 MEF2C PAX3
13 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.43 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
14 protein dimerization activity GO:0046983 9.23 MEF2A MEF2C MYF5 MYF6 MYOD1 MYOG
15 DNA binding GO:0003677 10.18 FOXO1 JDP2 MEF2A MEF2C MYF5 MYF6

Sources for Skeletal Muscle Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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