MCID: SKL007
MIFTS: 32

Skeletal Muscle Regeneration malady

Categories: Bone diseases

Aliases & Classifications for Skeletal Muscle Regeneration

Aliases & Descriptions for Skeletal Muscle Regeneration:

Name: Skeletal Muscle Regeneration 71
Hereditary Inclusion Body Myopathy 71
Nonaka Myopathy 69

Classifications:



Summaries for Skeletal Muscle Regeneration

MalaCards based summary : Skeletal Muscle Regeneration, also known as hereditary inclusion body myopathy, is related to mixed type rhabdomyosarcoma and verruciform xanthoma of skin. An important gene associated with Skeletal Muscle Regeneration is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and miRs in Muscle Cell Differentiation. The drugs Dipeptidyl-Peptidase IV Inhibitors and HIV Protease Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, endothelial and bone, and related phenotypes are Decreased ionizing radiation sensitivity and muscle

Related Diseases for Skeletal Muscle Regeneration

Diseases related to Skeletal Muscle Regeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
id Related Disease Score Top Affiliating Genes
1 mixed type rhabdomyosarcoma 10.2 DES MYOD1
2 verruciform xanthoma of skin 10.2 DES MYOD1
3 intrahepatic bile duct cystadenoma 10.2 DES MYOD1
4 ectopic pregnancy 10.2 DES MYOD1
5 testis sarcoma 10.2 DES MYOD1
6 transitional cell carcinoma 10.2 DES MYOD1
7 ovarian cystadenoma 10.2 DES MYOD1
8 bile duct rhabdomyosarcoma 10.2 DES MYOD1
9 cardiac tamponade 10.2 DES MYOD1
10 extraosseous osteosarcoma 10.2 DES MYOD1
11 lung benign neoplasm 10.2 DES MYOD1
12 enchondromatosis dwarfism deafness 10.1 DES MYOD1
13 childhood medulloblastoma 10.1 DES MYOD1
14 spindle cell rhabdomyosarcoma 10.1 DES MYOD1
15 juvenile xanthogranuloma 10.1 DES MYOD1
16 kidney sarcoma 10.1 EZH2 MYOD1
17 diabetes persistent mullerian ducts 10.1 DES MYOD1
18 parameningeal embryonal rhabdomyosarcoma 10.1 ADAM12 LIF
19 mediastinum sarcoma 10.1 DES MYOD1
20 prostate rhabdomyosarcoma 10.0 DES MYOD1
21 preretinal fibrosis 10.0 ADAM12 DES
22 muscular dystrophy 10.0
23 advanced sleep-phase syndrome, familial, 2 10.0 DES MYOD1
24 obesity 10.0
25 rhabdomyosarcoma 2, alveolar 9.9 DES MYOD1
26 endotheliitis 9.9
27 myositis 9.8
28 leukemia 9.8
29 rhabdomyosarcoma 9.8
30 ischemia 9.8
31 kidney disease 9.7
32 compartment syndrome 9.7
33 thyroiditis 9.7
34 myotonic dystrophy 9.7
35 insulin-like growth factor i 9.7
36 dystrophinopathies 9.7
37 myotonic dystrophy 1 9.7
38 polymyositis 9.7
39 duchenne muscular dystrophy 9.7
40 hypoxia 9.7
41 inclusion body myositis 9.7
42 limb ischemia 9.7
43 tonsillitis 9.7
44 endometriosis 9.7

Graphical network of the top 20 diseases related to Skeletal Muscle Regeneration:



Diseases related to Skeletal Muscle Regeneration

Symptoms & Phenotypes for Skeletal Muscle Regeneration

GenomeRNAi Phenotypes related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased ionizing radiation sensitivity GR00232-A-1 9.02 ADAM12 DES EZH2 GJD4 LIF

MGI Mouse Phenotypes related to Skeletal Muscle Regeneration:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.17 ADAM12 BCL9 DES EZH2 GJD4 LIF

Drugs & Therapeutics for Skeletal Muscle Regeneration

Drugs for Skeletal Muscle Regeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dipeptidyl-Peptidase IV Inhibitors Phase 2
2 HIV Protease Inhibitors Phase 2
3 Hormone Antagonists Phase 2
4 Hormones Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
6 Hypoglycemic Agents Phase 2
7 Incretins Phase 2
8 insulin Phase 2
9 Insulin, Globin Zinc Phase 2
10
protease inhibitors Phase 2
11 Sitagliptin Phosphate Phase 2
12 Liver Extracts
13 Analgesics
14 Analgesics, Non-Narcotic
15 Anti-Inflammatory Agents
16 Anti-Inflammatory Agents, Non-Steroidal
17 Antirheumatic Agents
18 Peripheral Nervous System Agents
19 Caseins
20 Whey Protein Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Effects of Exercise and Inhibition of Dipeptidyl Peptidase-4 on Insulin Secretion in Subjects With Type 1 Diabetes Active, not recruiting NCT02127047 Phase 2
2 MYOHEARTâ„¢ (Myogenesis Heart Efficiency and Regeneration Trial) Unknown status NCT00054678 Phase 1
3 The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery Unknown status NCT00796588
4 Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration Completed NCT00832663
5 Protein Supplementation and Skeletal Muscle Healing Process Completed NCT02816411
6 Blood Flow, Muscle Regeneration and Sarcopenia Completed NCT01035060

Search NIH Clinical Center for Skeletal Muscle Regeneration

Genetic Tests for Skeletal Muscle Regeneration

Anatomical Context for Skeletal Muscle Regeneration

MalaCards organs/tissues related to Skeletal Muscle Regeneration:

39
Skeletal Muscle, Endothelial, Bone, T Cells, Monocytes, Myeloid, Tongue

Publications for Skeletal Muscle Regeneration

Articles related to Skeletal Muscle Regeneration:

(show top 50) (show all 311)
id Title Authors Year
1
Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization. ( 27760421 )
2017
2
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2CI+1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy. ( 27612437 )
2016
3
BRE facilitates skeletal muscle regeneration by promoting satellite cell motility and differentiation. ( 26740569 )
2016
4
Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling. ( 27281480 )
2016
5
Abnormal Skeletal Muscle Regeneration plus Mild Alterations in Mature Fiber Type Specification in Fktn-Deficient Dystroglycanopathy Muscular Dystrophy Mice. ( 26751696 )
2016
6
Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration. ( 26699421 )
2016
7
Stem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/Cxcr7 axis. ( 27736296 )
2016
8
Combination of small RNAs for skeletal muscle regeneration. ( 26625904 )
2016
9
Macrophage depletion impairs skeletal muscle regeneration: The roles of regulatory factors for muscle regeneration. ( 27888539 )
2016
10
Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration. ( 27035161 )
2016
11
Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration. ( 27855784 )
2016
12
Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration. ( 27376715 )
2016
13
Dietary Flaxseed Mitigates Impaired Skeletal Muscle Regeneration: in Vivo, in Vitro and in Silico Studies. ( 26941581 )
2016
14
Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease. ( 27486747 )
2016
15
FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation. ( 27010781 )
2016
16
REDOX CONTROL OF SKELETAL MUSCLE REGENERATION. ( 28027662 )
2016
17
The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration. ( 27617277 )
2016
18
HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2. ( 27672022 )
2016
19
Macrophage PPARI^, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration. ( 27836432 )
2016
20
The role of TGF-I^1 during skeletal muscle regeneration. ( 28035727 )
2016
21
Evaluation of skeletal muscle regeneration in experimental model after malnutrition. ( 27382997 )
2016
22
Peroxisome Proliferator Activated Receptor Beta (PPARI^) activity increases the immune response and shortens the early phases of skeletal muscle regeneration. ( 27939528 )
2016
23
Skeletal muscle regeneration and impact of aging and nutrition. ( 26690801 )
2016
24
Skeletal muscle regeneration in cancer cachexia. ( 26857538 )
2016
25
Regulatory T cells and skeletal muscle regeneration. ( 27479876 )
2016
26
Diet-induced Obesity and Matrix Metalloproteinase Gene Expression at the Onset of Skeletal Muscle Regeneration: 2078 Board #230 June 2, 2: 00 PM - 3: 30 PM. ( 27360903 )
2016
27
Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration. ( 27327351 )
2016
28
Fgf regulates dedifferentiation during skeletal muscle regeneration in adult zebrafish. ( 27267062 )
2016
29
MicroRNA-29a in Adult Muscle Stem Cells Controls Skeletal Muscle Regeneration During Injury and Exercise Downstream of Fibroblast Growth Factor-2. ( 26731484 )
2016
30
MicroRNA-155 facilitates skeletal muscle regeneration by balancing pro- and anti-inflammatory macrophages. ( 27277683 )
2016
31
Regulation of myogenesis and skeletal muscle regeneration: effects of oxygen levels on satellite cell activity. ( 27601440 )
2016
32
Skeletal muscle regeneration via engineered tissue culture over electrospun nanofibrous Chitosan/PVA scaffold. ( 26945909 )
2016
33
Macrophage Depletion Impairs Skeletal Muscle Regeneration: the Roles of Pro-fibrotic Factors, Inflammation, and Oxidative Stress. ( 27605219 )
2016
34
Cardiotoxin Induced Injury and Skeletal Muscle Regeneration. ( 27492166 )
2016
35
S100B protein in skeletal muscle regeneration: regulation of myoblast and macrophage functions. ( 27054019 )
2016
36
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. ( 26956195 )
2016
37
Differential Expression Of Pgc1I+4 During Skeletal Muscle Regeneration And Myogenic Differentiation: 2069 Board #221 June 2, 2: 00 PM - 3: 30 PM. ( 27360894 )
2016
38
Exercise conditioning in old mice improves skeletal muscle regeneration. ( 27306336 )
2016
39
Effects of intramuscular administration of 1I+,25(OH)2D3during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis. ( 27032903 )
2016
40
Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration. ( 27235995 )
2016
41
Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration. ( 25480916 )
2015
42
Interstitial Outburst of Angiogenic Factors During Skeletal Muscle Regeneration After Acute Mechanical Trauma. ( 26260512 )
2015
43
Long-Term Therapy With Omega-3 Ameliorates Myonecrosis and Benefits Skeletal Muscle Regeneration in Mdx Mice. ( 26011009 )
2015
44
PEDF-derived peptide promotes skeletal muscle regeneration through its mitogenic effect on muscle progenitor cells. ( 26040897 )
2015
45
Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regeneration. ( 25428992 )
2015
46
Inflammation during skeletal muscle regeneration and tissue remodeling-application to exercise-induced muscle damage management. ( 26526620 )
2015
47
EFFECT OF PLATELET RICH PLASMA CONCENTRATION ON SKELETAL MUSCLE REGENERATION: AN EXPERIMENTAL STUDY. ( 26652490 )
2015
48
Low Intensity Exercise Training Improves Skeletal Muscle Regeneration Potential. ( 26733888 )
2015
49
A role for Galgt1 in skeletal muscle regeneration. ( 25699169 )
2015
50
Stem cell activation in skeletal muscle regeneration. ( 25572293 )
2015

Variations for Skeletal Muscle Regeneration

Expression for Skeletal Muscle Regeneration

Search GEO for disease gene expression data for Skeletal Muscle Regeneration.

Pathways for Skeletal Muscle Regeneration

Pathways related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.94 DES MYOD1
2 10.18 EZH2 MYOD1

GO Terms for Skeletal Muscle Regeneration

Biological processes related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 skeletal muscle cell differentiation GO:0035914 9.16 BCL9 MYOD1
2 myoblast fusion GO:0007520 8.96 ADAM12 MYOD1
3 myotube differentiation involved in skeletal muscle regeneration GO:0014908 8.62 BCL9 MYOD1

Molecular functions related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 core promoter binding GO:0001047 8.96 EZH2 MYOD1
2 chromatin DNA binding GO:0031490 8.62 EZH2 MYOD1

Sources for Skeletal Muscle Regeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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