MCID: SKL007
MIFTS: 32

Skeletal Muscle Regeneration malady

Category: Bone diseases

Aliases & Classifications for Skeletal Muscle Regeneration

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Aliases & Descriptions for Skeletal Muscle Regeneration:

Name: Skeletal Muscle Regeneration 71
Hereditary Inclusion Body Myopathy 71
 
Nonaka Myopathy 68

Classifications:



Summaries for Skeletal Muscle Regeneration

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MalaCards based summary: Skeletal Muscle Regeneration, also known as hereditary inclusion body myopathy, is related to mixed type rhabdomyosarcoma and verruciform xanthoma of skin. An important gene associated with Skeletal Muscle Regeneration is MYOD1 (Myogenic Differentiation 1), and among its related pathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and miRs in Muscle Cell Differentiation. Affiliated tissues include skeletal muscle, endothelial and bone, and related mouse phenotypes are Decreased ionizing radiation sensitivity and muscle.

Related Diseases for Skeletal Muscle Regeneration

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Diseases related to Skeletal Muscle Regeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1mixed type rhabdomyosarcoma10.2DES, MYOD1
2verruciform xanthoma of skin10.2DES, MYOD1
3intrahepatic bile duct cystadenoma10.2DES, MYOD1
4ectopic pregnancy10.2DES, MYOD1
5testis sarcoma10.2DES, MYOD1
6transitional cell carcinoma10.2DES, MYOD1
7ovarian cystadenoma10.2DES, MYOD1
8bile duct rhabdomyosarcoma10.2DES, MYOD1
9cardiac tamponade10.2DES, MYOD1
10extraosseous osteosarcoma10.2DES, MYOD1
11lung benign neoplasm10.2DES, MYOD1
12enchondromatosis dwarfism deafness10.1DES, MYOD1
13childhood medulloblastoma10.1DES, MYOD1
14spindle cell rhabdomyosarcoma10.1DES, MYOD1
15juvenile xanthogranuloma10.1DES, MYOD1
16kidney sarcoma10.1EZH2, MYOD1
17diabetes persistent mullerian ducts10.1DES, MYOD1
18parameningeal embryonal rhabdomyosarcoma10.1ADAM12, LIF
19mediastinum sarcoma10.1DES, MYOD1
20prostate rhabdomyosarcoma10.0DES, MYOD1
21preretinal fibrosis10.0ADAM12, DES
22muscular dystrophy10.0
23advanced sleep-phase syndrome, familial, 210.0DES, MYOD1
24obesity10.0
25rhabdomyosarcoma 2, alveolar9.9DES, MYOD1
26endotheliitis9.9
27leukemia9.8
28rhabdomyosarcoma9.8
29ischemia9.8
30myositis9.8
31insulin-like growth factor i9.7
32myotonic dystrophy 19.7
33duchenne muscular dystrophy9.7
34inclusion body myositis9.7
35limb ischemia9.7
36tonsillitis9.7
37endometriosis9.7
38kidney disease9.7
39compartment syndrome9.7
40thyroiditis9.7
41myotonic dystrophy9.7
42dystrophinopathies9.7
43polymyositis9.7
44hypoxia9.7

Graphical network of the top 20 diseases related to Skeletal Muscle Regeneration:



Diseases related to skeletal muscle regeneration

Symptoms & Phenotypes for Skeletal Muscle Regeneration

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GenomeRNAi Phenotypes related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00232-A-18.7ADAM12, DES, EZH2, GJD4, LIF

MGI Mouse Phenotypes related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053696.8ADAM12, BCL9, DES, EZH2, GJD4, LIF

Drugs & Therapeutics for Skeletal Muscle Regeneration

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Drugs for Skeletal Muscle Regeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1insulinPhase 24646
2Insulin, Globin ZincPhase 24645
3Dipeptidyl-Peptidase IV InhibitorsPhase 2862
4Sitagliptin PhosphatePhase 2423
5IncretinsPhase 21579
6
protease inhibitorsPhase 25471
Synonyms:
 
protease inhibitors
7Hypoglycemic AgentsPhase 25896
8Hormone AntagonistsPhase 213180
9HIV Protease InhibitorsPhase 25470
10Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 213168
11HormonesPhase 214415
12Liver Extracts4067
13Peripheral Nervous System Agents23689
14Caseins108
15Antirheumatic Agents10956
16Analgesics11733
17Analgesics, Non-Narcotic6501
18Anti-Inflammatory Agents10729
19Anti-Inflammatory Agents, Non-Steroidal4443
20Whey ProteinNutraceutical227

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effects of Exercise and Inhibition of Dipeptidyl Peptidase-4 on Insulin Secretion in Subjects With Type 1 DiabetesActive, not recruitingNCT02127047Phase 2
2MYOHEARTâ„¢ (Myogenesis Heart Efficiency and Regeneration Trial)Unknown statusNCT00054678Phase 1
3The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver SurgeryUnknown statusNCT00796588
4Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle RegenerationCompletedNCT00832663
5Protein Supplementation and Skeletal Muscle Healing ProcessCompletedNCT02816411
6Blood Flow, Muscle Regeneration and SarcopeniaCompletedNCT01035060

Search NIH Clinical Center for Skeletal Muscle Regeneration

Genetic Tests for Skeletal Muscle Regeneration

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Anatomical Context for Skeletal Muscle Regeneration

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MalaCards organs/tissues related to Skeletal Muscle Regeneration:

36
Skeletal muscle, Endothelial, Bone, T cells, Monocytes, Myeloid, Tongue

Publications for Skeletal Muscle Regeneration

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Articles related to Skeletal Muscle Regeneration:

(show top 50)    (show all 311)
idTitleAuthorsYear
1
Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization. (27760421)
2017
2
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2CI+1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy. (27612437)
2016
3
BRE facilitates skeletal muscle regeneration by promoting satellite cell motility and differentiation. (26740569)
2016
4
Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling. (27281480)
2016
5
Abnormal Skeletal Muscle Regeneration plus Mild Alterations in Mature Fiber Type Specification in Fktn-Deficient Dystroglycanopathy Muscular Dystrophy Mice. (26751696)
2016
6
Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration. (26699421)
2016
7
Stem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/Cxcr7 axis. (27736296)
2016
8
Combination of small RNAs for skeletal muscle regeneration. (26625904)
2016
9
Macrophage depletion impairs skeletal muscle regeneration: The roles of regulatory factors for muscle regeneration. (27888539)
2016
10
Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration. (27035161)
2016
11
Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration. (27855784)
2016
12
Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration. (27376715)
2016
13
Dietary Flaxseed Mitigates Impaired Skeletal Muscle Regeneration: in Vivo, in Vitro and in Silico Studies. (26941581)
2016
14
Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease. (27486747)
2016
15
FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation. (27010781)
2016
16
REDOX CONTROL OF SKELETAL MUSCLE REGENERATION. (28027662)
2016
17
The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration. (27617277)
2016
18
HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2. (27672022)
2016
19
Macrophage PPARI^, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration. (27836432)
2016
20
The role of TGF-I^1 during skeletal muscle regeneration. (28035727)
2016
21
Evaluation of skeletal muscle regeneration in experimental model after malnutrition. (27382997)
2016
22
Peroxisome Proliferator Activated Receptor Beta (PPARI^) activity increases the immune response and shortens the early phases of skeletal muscle regeneration. (27939528)
2016
23
Skeletal muscle regeneration and impact of aging and nutrition. (26690801)
2016
24
Skeletal muscle regeneration in cancer cachexia. (26857538)
2016
25
Regulatory T cells and skeletal muscle regeneration. (27479876)
2016
26
Diet-induced Obesity and Matrix Metalloproteinase Gene Expression at the Onset of Skeletal Muscle Regeneration: 2078 Board #230 June 2, 2: 00 PM - 3: 30 PM. (27360903)
2016
27
Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration. (27327351)
2016
28
Fgf regulates dedifferentiation during skeletal muscle regeneration in adult zebrafish. (27267062)
2016
29
MicroRNA-29a in Adult Muscle Stem Cells Controls Skeletal Muscle Regeneration During Injury and Exercise Downstream of Fibroblast Growth Factor-2. (26731484)
2016
30
MicroRNA-155 facilitates skeletal muscle regeneration by balancing pro- and anti-inflammatory macrophages. (27277683)
2016
31
Regulation of myogenesis and skeletal muscle regeneration: effects of oxygen levels on satellite cell activity. (27601440)
2016
32
Skeletal muscle regeneration via engineered tissue culture over electrospun nanofibrous Chitosan/PVA scaffold. (26945909)
2016
33
Macrophage Depletion Impairs Skeletal Muscle Regeneration: the Roles of Pro-fibrotic Factors, Inflammation, and Oxidative Stress. (27605219)
2016
34
Cardiotoxin Induced Injury and Skeletal Muscle Regeneration. (27492166)
2016
35
S100B protein in skeletal muscle regeneration: regulation of myoblast and macrophage functions. (27054019)
2016
36
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. (26956195)
2016
37
Differential Expression Of Pgc1I+4 During Skeletal Muscle Regeneration And Myogenic Differentiation: 2069 Board #221 June 2, 2: 00 PM - 3: 30 PM. (27360894)
2016
38
Exercise conditioning in old mice improves skeletal muscle regeneration. (27306336)
2016
39
Effects of intramuscular administration of 1I+,25(OH)2D3during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis. (27032903)
2016
40
Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration. (27235995)
2016
41
Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration. (25480916)
2015
42
Interstitial Outburst of Angiogenic Factors During Skeletal Muscle Regeneration After Acute Mechanical Trauma. (26260512)
2015
43
Long-Term Therapy With Omega-3 Ameliorates Myonecrosis and Benefits Skeletal Muscle Regeneration in Mdx Mice. (26011009)
2015
44
PEDF-derived peptide promotes skeletal muscle regeneration through its mitogenic effect on muscle progenitor cells. (26040897)
2015
45
Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regeneration. (25428992)
2015
46
Inflammation during skeletal muscle regeneration and tissue remodeling-application to exercise-induced muscle damage management. (26526620)
2015
47
EFFECT OF PLATELET RICH PLASMA CONCENTRATION ON SKELETAL MUSCLE REGENERATION: AN EXPERIMENTAL STUDY. (26652490)
2015
48
Low Intensity Exercise Training Improves Skeletal Muscle Regeneration Potential. (26733888)
2015
49
A role for Galgt1 in skeletal muscle regeneration. (25699169)
2015
50
Stem cell activation in skeletal muscle regeneration. (25572293)
2015

Variations for Skeletal Muscle Regeneration

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Expression for genes affiliated with Skeletal Muscle Regeneration

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Search GEO for disease gene expression data for Skeletal Muscle Regeneration.

Pathways for genes affiliated with Skeletal Muscle Regeneration

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Pathways related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7DES, MYOD1
29.6EZH2, MYOD1

GO Terms for genes affiliated with Skeletal Muscle Regeneration

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Biological processes related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myoblast fusionGO:000752010.2ADAM12, MYOD1
2myotube differentiation involved in skeletal muscle regenerationGO:00149089.8BCL9, MYOD1
3skeletal muscle cell differentiationGO:00359149.3BCL9, MYOD1

Molecular functions related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:003149010.1EZH2, MYOD1
2core promoter bindingGO:00010479.6EZH2, MYOD1

Sources for Skeletal Muscle Regeneration

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet