MCID: SKL007
MIFTS: 36

Skeletal Muscle Regeneration malady

Category: Bone diseases

Aliases & Classifications for Skeletal Muscle Regeneration

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Aliases & Descriptions for Skeletal Muscle Regeneration:

Name: Skeletal Muscle Regeneration 68
Hereditary Inclusion Body Myopathy 68
 
Nonaka Myopathy 65

Classifications:



External Ids:

UMLS65 C1853926

Summaries for Skeletal Muscle Regeneration

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MalaCards based summary: Skeletal Muscle Regeneration, also known as hereditary inclusion body myopathy, is related to hereditary inclusion body myopathy type 4 and muscular dystrophy. An important gene associated with Skeletal Muscle Regeneration is GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase), and among its related pathways are WNT ligand biogenesis and trafficking and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include skeletal muscle, liver and bone, and related mouse phenotype muscle.

Related Diseases for Skeletal Muscle Regeneration

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Graphical network of the top 20 diseases related to Skeletal Muscle Regeneration:



Diseases related to skeletal muscle regeneration

Symptoms for Skeletal Muscle Regeneration

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Drugs & Therapeutics for Skeletal Muscle Regeneration

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Drugs for Skeletal Muscle Regeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1insulinPhase 24278
2Dipeptidyl-Peptidase IV InhibitorsPhase 2779
3Protease InhibitorsPhase 24558
4Sitagliptin PhosphatePhase 2399
5IncretinsPhase 21326
6Insulin, Globin ZincPhase 24278
7Hypoglycemic AgentsPhase 24503
8HIV Protease InhibitorsPhase 24558
9Hormone AntagonistsPhase 210002
10HormonesPhase 211748
11Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
12Antirheumatic Agents8496
13Peripheral Nervous System Agents18510
14Anti-Inflammatory Agents, Non-Steroidal3549
15Analgesics9358
16Anti-Inflammatory Agents8478
17Analgesics, Non-Narcotic5184
18Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effects of Exercise and Inhibition of Dipeptidyl Peptidase-4 on Insulin Secretion in Subjects With Type 1 DiabetesRecruitingNCT02127047Phase 2
2MYOHEARTâ„¢ (Myogenesis Heart Efficiency and Regeneration Trial)Active, not recruitingNCT00054678Phase 1
3Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle RegenerationCompletedNCT00832663
4Blood Flow, Muscle Regeneration and SarcopeniaCompletedNCT01035060
5The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver SurgeryEnrolling by invitationNCT00796588

Search NIH Clinical Center for Skeletal Muscle Regeneration

Genetic Tests for Skeletal Muscle Regeneration

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Anatomical Context for Skeletal Muscle Regeneration

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MalaCards organs/tissues related to Skeletal Muscle Regeneration:

33
Skeletal muscle, Liver, Bone, Brain, Endothelial, Thyroid, Heart

Animal Models for Skeletal Muscle Regeneration or affiliated genes

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MGI Mouse Phenotypes related to Skeletal Muscle Regeneration:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2ADAM12, BCL9, GNE, WNT10B

Publications for Skeletal Muscle Regeneration

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Articles related to Skeletal Muscle Regeneration:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
BRE facilitates skeletal muscle regeneration by promoting satellite cell motility and differentiation. (26740569)
2016
2
Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration. (27035161)
2016
3
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. (26956195)
2016
4
FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation. (27010781)
2016
5
Adult Stem Cells and Skeletal Muscle Regeneration. (26122100)
2015
6
Neuraminidase-1 mediates skeletal muscle regeneration. (26001931)
2015
7
Poly(3,4-ethylenedioxythiophene) Nanoparticle and Poly(I/-caprolactone) Electrospun Scaffold Characterization for Skeletal Muscle Regeneration. (25855940)
2015
8
Inflammation during skeletal muscle regeneration and tissue remodeling-application to exercise-induced muscle damage management. (26526620)
2015
9
Diet-induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration. (26052759)
2015
10
Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration. (25670800)
2015
11
Leucine supplementation improves skeletal muscle regeneration after cryolesion in rats. (24416379)
2014
12
Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy. (25452464)
2014
13
Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury. (23608055)
2013
14
Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration. (23384231)
2013
15
Myeloid hypoxia-inducible factor-1I+ is essential for skeletal muscle regeneration in mice. (23729446)
2013
16
Delta-like 1 homolog (dlk1): a marker for rhabdomyosarcomas implicated in skeletal muscle regeneration. (23577150)
2013
17
microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. (22546853)
2012
18
Biochemical and mechanical environment cooperatively regulate skeletal muscle regeneration. (22415307)
2012
19
Tissue engineering for skeletal muscle regeneration. (23738301)
2012
20
MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration. (22279050)
2012
21
Sca-1 influences the innate immune response during skeletal muscle regeneration. (21123737)
2011
22
PC4/Tis7/IFRD1 stimulates skeletal muscle regeneration and is involved in myoblast differentiation as a regulator of MyoD and NF-kappaB. (21127072)
2011
23
Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration. (20042733)
2010
24
Sca-1 expression is required for efficient remodeling of the extracellular matrix during skeletal muscle regeneration. (19059231)
2009
25
Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy. (19401296)
2009
26
Acceleration of skeletal muscle regeneration in a rat skeletal muscle injury model by local injection of human peripheral blood-derived CD133-positive cells. (19353523)
2009
27
Age influences the early events of skeletal muscle regeneration: studies of whole muscle grafts transplanted between young (8 weeks) and old (13-21 months) mice. (18364250)
2008
28
Tumor necrosis factor-alpha inhibition of skeletal muscle regeneration is mediated by a caspase-dependent stem cell response. (18258721)
2008
29
Delayed angiogenesis and VEGF production in CCR2-/- mice during impaired skeletal muscle regeneration. (17522124)
2007
30
AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration. (17185750)
2007
31
Skeletal muscle regeneration may be enhanced by overexpression of aquaporin 1 in intramuscular capillary endothelial cells. (17052860)
2007
32
Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. (17823291)
2007
33
Increased expression of deltaCaMKII isoforms in skeletal muscle regeneration: Implications in dystrophic muscle disease. (16215994)
2006
34
The plasminogen activation system in skeletal muscle regeneration: antagonistic roles of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1). (15970552)
2005
35
Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. (15353585)
2004
36
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation. (14627628)
2004
37
Highly coordinated gene regulation in mouse skeletal muscle regeneration. (12477723)
2003
38
Mitochondrial biogenesis during skeletal muscle regeneration. (11882500)
2002
39
Skeletal muscle regeneration after insulin-like growth factor I gene transfer by recombinant Sendai virus vector. (11526451)
2001
40
Murray L. Barr Award Lecture. Studies of the dynamics of skeletal muscle regeneration: the mouse came back! (9666302)
1998
41
Growth factors in skeletal muscle regeneration. (8971480)
1996
42
Skeletal muscle regeneration after injury: an overview. (8167787)
1994
43
Effect of torbafylline on mitochondrial calmitine in mouse skeletal muscle regeneration after injection of a myotoxic drug. (8229057)
1993
44
The effect of X-irradiation on skeletal muscle regeneration in the adult rat. (3572447)
1987
45
Time course of changes in protein synthesis in marcaine-induced skeletal muscle regeneration. (6083423)
1984
46
Skeletal muscle regeneration. (7017402)
1981
47
Skeletal muscle: regeneration and transplantation studies. (7020842)
1980
48
Choline acetyltransferase and cholinesterase in skeletal muscle regeneration. (1123632)
1975
49
Origin of myoblasts during skeletal muscle regeneration. Electron microscopic observations. (5776329)
1969
50

Variations for Skeletal Muscle Regeneration

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Clinvar genetic disease variations for Skeletal Muscle Regeneration:

5
id Gene Variation Type Significance SNP ID Assembly Location
1GNENM_001128227.2(GNE): c.2228T> C (p.Met743Thr)single nucleotide variantPathogenicrs28937594GRCh37Chr 9, 36217396: 36217396
2GNENM_005476.5(GNE): c.2086G> A (p.Val696Met)single nucleotide variantLikely pathogenic, Pathogenicrs121908627GRCh37Chr 9, 36217445: 36217445
3GNENM_001128227.2(GNE): c.830G> A (p.Arg277Gln)single nucleotide variantPathogenicrs121908629GRCh37Chr 9, 36236861: 36236861
4GNENM_005476.5(GNE): c.1714G> C (p.Val572Leu)single nucleotide variantPathogenicrs121908632GRCh37Chr 9, 36219937: 36219937
5GNENM_001128227.2(GNE): c.1985C> T (p.Ala662Val)single nucleotide variantPathogenicrs62541771GRCh37Chr 9, 36218221: 36218221

Expression for genes affiliated with Skeletal Muscle Regeneration

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Search GEO for disease gene expression data for Skeletal Muscle Regeneration.

Pathways for genes affiliated with Skeletal Muscle Regeneration

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GO Terms for genes affiliated with Skeletal Muscle Regeneration

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Biological processes related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chondrocyte differentiationGO:00020629.5WNT10B, WNT7A
2cell fate commitmentGO:00451659.4WNT10B, WNT7A
3neuron differentiationGO:00301829.4WNT10B, WNT7A
4Wnt signaling pathwayGO:00160559.1WNT10B, WNT7A
5positive regulation of canonical Wnt signaling pathwayGO:00902639.0WNT10B, WNT7A
6canonical Wnt signaling pathwayGO:00600708.6BCL9, WNT10B, WNT7A

Sources for Skeletal Muscle Regeneration

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet