MCID: SKL007
MIFTS: 42

Skeletal Muscle Regeneration malady

Bone diseases category

Summaries for Skeletal Muscle Regeneration

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hereditary inclusion body myopathies (HIBM) are a heterogeneous group of genetic disorders which have... more...

MalaCards: Skeletal Muscle Regeneration, also known as hereditary inclusion body myopathy, is related to muscular dystrophy and ischemia. An important gene associated with Skeletal Muscle Regeneration is WNT10B (wingless-type MMTV integration site family, member 10B), and among its related pathways are Basal cell carcinoma and Transcription Androgen Receptor nuclear signaling. The compounds matrigel and prostaglandin have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, endothelial and bone, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Skeletal Muscle Regeneration

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63Wikipedia
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

skeletal muscle regeneration 63
hereditary inclusion body myopathy 63


Related Diseases for Skeletal Muscle Regeneration

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Skeletal Muscle Regeneration:



Diseases related to skeletal muscle regeneration

Clinical Features for Skeletal Muscle Regeneration

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Drugs & Therapeutics for Skeletal Muscle Regeneration

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Skeletal Muscle Regeneration

Drug clinical trials:

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Search NIH Clinical Center for Skeletal Muscle Regeneration

Search CenterWatch for Skeletal Muscle Regeneration

Genetic Tests for Skeletal Muscle Regeneration

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Anatomical Context for Skeletal Muscle Regeneration

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32MalaCards
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MalaCards organs/tissues related to Skeletal Muscle Regeneration:

32
Skeletal muscle, Endothelial, Bone, Bone marrow, Tongue, Myeloid, Monocytes

Animal Models for Skeletal Muscle Regeneration or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Skeletal Muscle Regeneration:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.7AQP1, PLAU, WNT7A, MYOD1, LIF
2MP:00053698.9BCL9, CAPN3, SOX15, LIF, MYOD1, CXCL12
3MP:00053858.7CAPN3, FZD7, LIF, MYOD1, CXCL12, WNT7A

Publications for Skeletal Muscle Regeneration

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50PubMed
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Articles related to Skeletal Muscle Regeneration:

(show top 50)    (show all 260)
idTitleAuthorsYear
1
Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration. (23384231)
2013
2
Epigenetic control of skeletal muscle regeneration: Integrating genetic determinants and environmental changes. (23745685)
2013
3
How sex hormones promote skeletal muscle regeneration. (23888432)
2013
4
Lack of Smad3 signaling leads to impaired skeletal muscle regeneration. (22535746)
2012
5
HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration. (23023707)
2012
6
Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration. (21709151)
2011
7
Rantes secreted from macrophages disturbs skeletal muscle regeneration after cardiotoxin injection in Cbl-b-deficient mice. (21254087)
2011
8
Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice. (21264243)
2011
9
Alternative splicing dysregulation secondary to skeletal muscle regeneration. (21400563)
2011
10
Nonmyogenic cells in skeletal muscle regeneration. (21621070)
2011
11
GI+i2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regeneration. (22126963)
2011
12
Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration. (21427212)
2011
13
Time course of skeletal muscle regeneration after severe trauma. (21142822)
2011
14
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. (21828093)
2011
15
Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration. (18662193)
2009
16
Immunoneutralization of TGFbeta1 Improves Skeletal Muscle Regeneration: Effects on Myoblast Differentiation and Glycosaminoglycan Content. (20111627)
2009
17
The effects of long-term experimental diabetes mellitus type I on skeletal muscle regeneration capacity. (20102056)
2009
18
Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration. (19812386)
2009
19
Tumor necrosis factor-alpha inhibition of skeletal muscle regeneration is mediated by a caspase-dependent stem cell response. (18258721)
2008
20
Exercise-induced stem cell activation and its implication for cardiovascular and skeletal muscle regeneration. (18465444)
2008
21
Skeletal muscle regeneration may be enhanced by overexpression of aquaporin 1 in intramuscular capillary endothelial cells. (17052860)
2007
22
Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. (17823291)
2007
23
Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy. (17947802)
2007
24
A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. (18086917)
2007
25
p66(ShcA) and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia. (17726026)
2007
26
Increased expression of deltaCaMKII isoforms in skeletal muscle regeneration: Implications in dystrophic muscle disease. (16215994)
2006
27
Increased adipogenicity of cells from regenerating skeletal muscle. (16750191)
2006
28
Rskalpha-actin/hIGF-1 transgenic mice with increased IGF-I in skeletal muscle and blood: impact on regeneration, denervation and muscular dystrophy. (16716629)
2006
29
Neprilysin participates in skeletal muscle regeneration and is accumulated in abnormal muscle fibres of inclusion body myositis. (16405511)
2006
30
Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population. (16449193)
2006
31
The plasminogen activation system in skeletal muscle regeneration: antagonistic roles of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1). (15970552)
2005
32
Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration. (15716324)
2005
33
Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. (15353585)
2004
34
Mitochondrial biogenesis during skeletal muscle regeneration. (11882500)
2002
35
Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo. (11929773)
2002
36
Skeletal muscle regeneration associated with the stroma reaction during tumor invasion in the rat tongue. (12575835)
2002
37
Skeletal muscle regeneration after insulin-like growth factor I gene transfer by recombinant Sendai virus vector. (11526451)
2001
38
Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo. (11238111)
2001
39
The role of tumor necrosis factor-alpha (TNF-alpha) in skeletal muscle regeneration. Studies in TNF-alpha(-/-) and TNF-alpha(-/-)/LT-alpha(-/-) mice. (11457927)
2001
40
Gene expression of receptors for IL-6, LIF, and CNTF in regenerating skeletal muscles. (10950877)
2000
41
The role of leukemia inhibitory factor in skeletal muscle regeneration. (9179153)
1997
42
Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: injured muscle expresses lif mRNA. (8064301)
1994
43
Enhancement of skeletal muscle regeneration. (7803846)
1994
44
Immunohistochemical analysis of myoblast proliferation and differentiation in experimental skeletal muscle regeneration. (8105886)
1993
45
Molecular and cell biology of skeletal muscle regeneration. (8111541)
1993
46
The dystrophin-related protein, utrophin, is expressed on the sarcolemma of regenerating human skeletal muscle fibres in dystrophies and inflammatory myopathies. (1483043)
1992
47
Skeletal muscle regeneration in young rats is dependent on growth hormone. (1779241)
1991
48
Effects of skeletal muscle regeneration on the proliferation potential of satellite cells. (3999814)
1985
49
Glycolysis in skeletal muscle regeneration. (133807)
1976
50
A histological and histochemical study of skeletal muscle regeneration in polymyositis. (5444895)
1970

Genetic Variations for Skeletal Muscle Regeneration

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Expression for genes affiliated with Skeletal Muscle Regeneration

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skeletal Muscle Regeneration

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Pathways for genes affiliated with Skeletal Muscle Regeneration

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29KEGG, 59Tocris Bioscience, 12EMD Millipore, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database
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Compounds for genes affiliated with Skeletal Muscle Regeneration

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Skeletal Muscle Regeneration according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1matrigel4410.1PLAU, MME, CXCL12, LIF
2prostaglandin4410.1LIF, MYOD1, CXCL12, MME
3ribonucleic acid4410.0LIF, CXCL12, MME, PLAU
4paraffin449.9AQP1, PLAU, MME, MYOD1, LIF
5gp 130449.9LIF, MYOD1, CXCL12
612-o-tetradecanoylphorbol 13-acetate449.9PLAU, MME, MYOD1, LIF
7actinomycin d449.9LIF, MYOD1, CXCL12, MME, PLAU
8potassium44 11 2411.9AQP1, MME, CXCL12, LIF
9azathioprine44 49 2 1112.8PLAU, MYOD1, LIF
10progesterone44 59 28 11 2413.8LIF, CXCL12, WNT10B, MME, PLAU
11creatinine449.8CAPN3, LIF, MYOD1, MME, PLAU, AQP1
12vegf449.7LIF, MYOD1, CXCL12, MME, PLAU, AQP1
13arginine449.7LIF, MYOD1, CXCL12, MME, PLAU, AQP1
14steroid449.7LIF, MYOD1, CXCL12, WNT7A, MME, PLAU
15estrogen449.7LIF, MYOD1, CXCL12, WNT7A, MME, PLAU
16serine449.6LIF, MYOD1, RRAD
17cysteine449.6AQP1, PLAU, MME, MYOD1, LIF, CAPN3
18calcium44 49 11 2411.8AQP1, CAPN3, FZD7, LIF, MYOD1, CD101

GO Terms for genes affiliated with Skeletal Muscle Regeneration

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16Gene Ontology
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Cellular components related to Skeletal Muscle Regeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.6PLAU, WNT7A, WNT10B, CXCL12, LIF, TNFSF12

Biological processes related to Skeletal Muscle Regeneration according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1cellular response to salt stressGO:07147210.4CAPN3, AQP1
2positive regulation of satellite cell activation involved in skeletal muscle regenerationGO:01471810.3CAPN3, SOX15
3myotube differentiation involved in skeletal muscle regenerationGO:01490810.3MYOD1, BCL9
4satellite cell maintenance involved in skeletal muscle regenerationGO:01483410.3WNT7A, FZD7
5positive regulation of epithelial cell proliferation involved in wound healingGO:06005410.3WNT7A, FZD7
6somatic stem cell divisionGO:04810310.1WNT7A, FZD7
7canonical Wnt receptor signaling pathwayGO:06007010.1BCL9, WNT7A, WNT10B, FZD7
8cellular response to retinoic acidGO:07130010.1FZD7, WNT10B, AQP1
9neuron differentiationGO:0301829.9WNT7A, WNT10B, FZD7
10skeletal muscle fiber developmentGO:0487419.8MYOD1, WNT10B
11positive regulation of transcription from RNA polymerase II promoterGO:0459449.7BCL9, WNT7A, MYOD1, LIF, SOX15

Molecular functions related to Skeletal Muscle Regeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor agonist activityGO:04801810.2WNT7A, WNT10B
2titin bindingGO:0314329.9ACTN2, CAPN3
3receptor bindingGO:0051029.8TNFSF12, LIF, CXCL12, WNT7A
4protein bindingGO:0055158.2AQP1, CAPN3, TNFRSF12A, TNFSF12, FZD7, MYOD1

Products for genes affiliated with Skeletal Muscle Regeneration

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Sources for Skeletal Muscle Regeneration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet