MCID: SKL007
MIFTS: 33

Skeletal Muscle Regeneration

Categories: Bone diseases

Aliases & Classifications for Skeletal Muscle Regeneration

MalaCards integrated aliases for Skeletal Muscle Regeneration:

Name: Skeletal Muscle Regeneration 72
Hereditary Inclusion Body Myopathy 72
Nonaka Myopathy 69

Classifications:



Summaries for Skeletal Muscle Regeneration

MalaCards based summary : Skeletal Muscle Regeneration, also known as hereditary inclusion body myopathy, is related to ischemia and spleen cancer. An important gene associated with Skeletal Muscle Regeneration is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Signaling pathways regulating pluripotency of stem cells and WNT ligand biogenesis and trafficking. The drugs Dipeptidyl-Peptidase IV Inhibitors and HIV Protease Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and bone, and related phenotypes are cardiovascular system and muscle

Related Diseases for Skeletal Muscle Regeneration

Diseases related to Skeletal Muscle Regeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
id Related Disease Score Top Affiliating Genes
1 ischemia 30.2 DES MYOD1
2 spleen cancer 10.4 DES MYOD1
3 omphalocele 10.4 DES MYOD1
4 testis rhabdomyosarcoma 10.4 DES MYOD1
5 transitional cell carcinoma 10.4 DES MYOD1
6 mucinous ovarian cystadenoma 10.4 DES MYOD1
7 granular cell leiomyosarcoma 10.4 DES MYOD1
8 cardiac tamponade 10.4 DES MYOD1
9 localized osteosarcoma 10.3 DES MYOD1
10 enamel hypoplasia cataract hydrocephaly 10.3 DES MYOD1
11 melanotic medulloblastoma 10.3 DES MYOD1
12 lung clear cell-sugar-tumor 10.3 DES MYOD1
13 mediastinum rhabdomyosarcoma 10.2 DES MYOD1
14 cerebrum cancer 10.2 DES MYOD1
15 pulmonary immaturity 10.2 EZH2 MYOD1
16 dextrocardia with situs inversus 10.2 DES MYOD1
17 obesity 10.1
18 prostate embryonal rhabdomyosarcoma 10.1 DES MYOD1
19 muscular dystrophy 10.0
20 3-methylglutaconic aciduria 10.0 ADAM12 LIF
21 preretinal fibrosis 10.0 ADAM12 DES
22 rhabdomyosarcoma 2, alveolar 10.0 DES MYOD1
23 endotheliitis 9.9
24 neuromuscular junction disease 9.9 DES WNT7A
25 leukemia 9.8
26 rhabdomyosarcoma 9.8
27 myositis 9.8
28 46xy sex reversal 5 9.8 DES MYOD1
29 insulin-like growth factor i 9.7
30 myotonic dystrophy 1 9.7
31 duchenne muscular dystrophy 9.7
32 inclusion body myositis 9.7
33 limb ischemia 9.7
34 tonsillitis 9.7
35 endometriosis 9.7
36 kidney disease 9.7
37 compartment syndrome 9.7
38 thyroiditis 9.7
39 myotonic dystrophy 9.7
40 dystrophinopathies 9.7
41 polymyositis 9.7
42 hypoxia 9.7
43 immunodeficiency, centromere instability and facial anomalies syndrome 7.1 ADAM12 CMYA5 DES EZH2 LIF MYOD1

Graphical network of the top 20 diseases related to Skeletal Muscle Regeneration:



Diseases related to Skeletal Muscle Regeneration

Symptoms & Phenotypes for Skeletal Muscle Regeneration

MGI Mouse Phenotypes related to Skeletal Muscle Regeneration:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 ADAM12 DES EZH2 LIF MYOD1 WNT7A
2 muscle MP:0005369 9.1 DES EZH2 LIF MYOD1 WNT10B ADAM12

Drugs & Therapeutics for Skeletal Muscle Regeneration

Drugs for Skeletal Muscle Regeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Dipeptidyl-Peptidase IV Inhibitors Phase 2
2 HIV Protease Inhibitors Phase 2
3 Hormone Antagonists Phase 2
4 Hormones Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
6 Hypoglycemic Agents Phase 2
7 Incretins Phase 2
8 insulin Phase 2
9 Insulin, Globin Zinc Phase 2
10
protease inhibitors Phase 2
11 Sitagliptin Phosphate Phase 2
12 Liver Extracts
13 Analgesics
14 Analgesics, Non-Narcotic
15 Anti-Inflammatory Agents
16 Anti-Inflammatory Agents, Non-Steroidal
17 Antirheumatic Agents
18 Peripheral Nervous System Agents
19 Caseins
20 Whey Protein Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effects of Exercise and Inhibition of Dipeptidyl Peptidase-4 on Insulin Secretion in Subjects With Type 1 Diabetes Completed NCT02127047 Phase 2 Sitagliptin;Exercise
2 The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery Unknown status NCT00796588
3 Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration Completed NCT00832663 NSAID;placebo
4 Protein Supplementation and Skeletal Muscle Healing Process Completed NCT02816411
5 Blood Flow, Muscle Regeneration and Sarcopenia Completed NCT01035060

Search NIH Clinical Center for Skeletal Muscle Regeneration

Genetic Tests for Skeletal Muscle Regeneration

Anatomical Context for Skeletal Muscle Regeneration

MalaCards organs/tissues related to Skeletal Muscle Regeneration:

39
Skeletal Muscle, Liver, Bone, Endothelial, Myeloid, Monocytes, T Cells

Publications for Skeletal Muscle Regeneration

Articles related to Skeletal Muscle Regeneration:

(show top 50) (show all 326)
id Title Authors Year
1
Biocompatible Elastic Conductive Films Significantly Enhanced Myogenic Differentiation of Myoblast for Skeletal Muscle Regeneration. ( 28792734 )
2017
2
Regulation and phylogeny of skeletal muscle regeneration. ( 28811217 )
2017
3
Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity. ( 28725215 )
2017
4
The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration. ( 28332979 )
2017
5
Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection. ( 28117768 )
2017
6
Laminin-111 enriched fibrin hydrogels for skeletal muscle regeneration. ( 28697464 )
2017
7
Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization. ( 27760421 )
2017
8
Skeletal muscle regeneration involves macrophage-myoblast bonding. ( 28759306 )
2017
9
Characterizing Satellite Cells and Myogenic Progenitors During Skeletal Muscle Regeneration. ( 28155153 )
2017
10
5-Azacytidine-mediated hMSC behavior on electrospun scaffolds for skeletal muscle regeneration. ( 28512793 )
2017
11
(*) Design of an In Vitro Model of Cell Recruitment for Skeletal Muscle Regeneration Using Hepatocyte Growth Factor-Loaded Fibrin Microthreads. ( 28351217 )
2017
12
Metabolic regulation of macrophages during tissue repair: insights from skeletal muscle regeneration. ( 28555751 )
2017
13
Systemic Regulators of Skeletal Muscle Regeneration in Obesity. ( 28261159 )
2017
14
lncRNA-Encoded Polypeptide SPAR(s) with mTORC1 to Regulate Skeletal Muscle Regeneration. ( 28388426 )
2017
15
Neuromuscular electrical stimulation improves skeletal muscle regeneration through satellite cell fusion with myofibers in healthy elderly subjects. ( 28572500 )
2017
16
Fibroblasts take the centre stage in human skeletal muscle regeneration. ( 28585689 )
2017
17
HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2. ( 27672022 )
2016
18
Regulatory T cells and skeletal muscle regeneration. ( 27479876 )
2016
19
Diet-induced Obesity and Matrix Metalloproteinase Gene Expression at the Onset of Skeletal Muscle Regeneration: 2078 Board #230 June 2, 2: 00 PM - 3: 30 PM. ( 27360903 )
2016
20
BRE facilitates skeletal muscle regeneration by promoting satellite cell motility and differentiation. ( 26740569 )
2016
21
The role of TGF-I^1 during skeletal muscle regeneration. ( 28035727 )
2016
22
Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. ( 26956195 )
2016
23
MicroRNA-29a in Adult Muscle Stem Cells Controls Skeletal Muscle Regeneration During Injury and Exercise Downstream of Fibroblast Growth Factor-2. ( 26731484 )
2016
24
Abnormal Skeletal Muscle Regeneration plus Mild Alterations in Mature Fiber Type Specification in Fktn-Deficient Dystroglycanopathy Muscular Dystrophy Mice. ( 26751696 )
2016
25
Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration. ( 27855784 )
2016
26
Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling. ( 27281480 )
2016
27
Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration. ( 27235995 )
2016
28
Exercise conditioning in old mice improves skeletal muscle regeneration. ( 27306336 )
2016
29
Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration. ( 26699421 )
2016
30
Macrophage PPARI^, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration. ( 27836432 )
2016
31
Skeletal muscle regeneration via engineered tissue culture over electrospun nanofibrous Chitosan/PVA scaffold. ( 26945909 )
2016
32
Skeletal muscle regeneration and impact of aging and nutrition. ( 26690801 )
2016
33
Macrophage Depletion Impairs Skeletal Muscle Regeneration: the Roles of Pro-fibrotic Factors, Inflammation, and Oxidative Stress. ( 27605219 )
2016
34
S100B protein in skeletal muscle regeneration: regulation of myoblast and macrophage functions. ( 27054019 )
2016
35
Regulation of myogenesis and skeletal muscle regeneration: effects of oxygen levels on satellite cell activity. ( 27601440 )
2016
36
FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation. ( 27010781 )
2016
37
Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration. ( 27035161 )
2016
38
The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration. ( 27617277 )
2016
39
Fgf regulates dedifferentiation during skeletal muscle regeneration in adult zebrafish. ( 27267062 )
2016
40
Stem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/Cxcr7 axis. ( 27736296 )
2016
41
Cardiotoxin Induced Injury and Skeletal Muscle Regeneration. ( 27492166 )
2016
42
Combination of small RNAs for skeletal muscle regeneration. ( 26625904 )
2016
43
REDOX CONTROL OF SKELETAL MUSCLE REGENERATION. ( 28027662 )
2016
44
Effects of intramuscular administration of 1I+,25(OH)2D3during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis. ( 27032903 )
2016
45
Peroxisome Proliferator Activated Receptor Beta (PPARI^) activity increases the immune response and shortens the early phases of skeletal muscle regeneration. ( 27939528 )
2016
46
Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration. ( 27327351 )
2016
47
Dynamic Phosphorylation of the Myocyte Enhancer Factor 2CI+1 Splice Variant Promotes Skeletal Muscle Regeneration and Hypertrophy. ( 27612437 )
2016
48
Differential Expression Of Pgc1I+4 During Skeletal Muscle Regeneration And Myogenic Differentiation: 2069 Board #221 June 2, 2: 00 PM - 3: 30 PM. ( 27360894 )
2016
49
MicroRNA-155 facilitates skeletal muscle regeneration by balancing pro- and anti-inflammatory macrophages. ( 27277683 )
2016
50
Evaluation of skeletal muscle regeneration in experimental model after malnutrition. ( 27382997 )
2016

Variations for Skeletal Muscle Regeneration

Expression for Skeletal Muscle Regeneration

Search GEO for disease gene expression data for Skeletal Muscle Regeneration.

Pathways for Skeletal Muscle Regeneration

GO Terms for Skeletal Muscle Regeneration

Biological processes related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.71 LIF MYOD1 WNT10B WNT7A
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.67 LIF MYOD1 WNT10B WNT7A
3 canonical Wnt signaling pathway GO:0060070 9.43 WNT10B WNT7A
4 cell fate commitment GO:0045165 9.32 WNT10B WNT7A
5 chondrocyte differentiation GO:0002062 9.26 WNT10B WNT7A
6 skeletal muscle fiber development GO:0048741 9.16 MYOD1 WNT10B
7 myoblast fusion GO:0007520 8.96 ADAM12 MYOD1
8 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 8.62 EZH2 WNT7A

Molecular functions related to Skeletal Muscle Regeneration according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.5 LIF WNT10B WNT7A
2 core promoter binding GO:0001047 9.26 EZH2 MYOD1
3 chromatin DNA binding GO:0031490 9.16 EZH2 MYOD1
4 frizzled binding GO:0005109 8.96 WNT10B WNT7A
5 receptor agonist activity GO:0048018 8.62 WNT10B WNT7A

Sources for Skeletal Muscle Regeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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