MCID: SKN005
MIFTS: 36

Skin Atrophy malady

Skin category

Summaries for Skin Atrophy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Atrophoderma refers to conditions involving skin atrophy. more...

MalaCards: Skin Atrophy, also known as atrophic condition of skin, is related to kindler syndrome and atrophoderma of pierini and pasini. An important gene associated with Skin Atrophy is KL (klotho), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Immune response MIF-mediated glucocorticoid regulation. The compounds 3beta-hydroxysteroid and glycyrrhetinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and spinal cord, and related mouse phenotype integument.

Aliases & Classifications for Skin Atrophy

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

skin atrophy 8 10
atrophic condition of skin 8 61
atrophy - skin 8
atrophoderma 8


External Ids:

Disease Ontology8 DOID:2733
NCIt40 C35163

Related Diseases for Skin Atrophy

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Skin Atrophy:



Diseases related to skin atrophy

Clinical Features for Skin Atrophy

Drugs & Therapeutics for Skin Atrophy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Skin Atrophy

Anatomical Context for Skin Atrophy

Sources:
33MalaCards
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MalaCards organs/tissues related to Skin Atrophy:

33
Skin, Tongue, Spinal cord, Retina, Skeletal muscle, Thyroid

Animal Models for Skin Atrophy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Skin Atrophy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5GJA1, EBP, NR3C1, FERMT1, KL

Publications for Skin Atrophy

Sources:
51PubMed
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Articles related to Skin Atrophy:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Novel SPG10 mutation associated with dysautonomia, spinal cord atrophy, and skin biopsy abnormality. (22788249)
2013
2
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. (23242470)
2013
3
Incontinentia pigmenti: a newborn with characteristic skin lesions and bilateral optic atrophy: case report and review of literature. (24390952)
2013
4
Skin temperature of the hand in multiple system atrophy and Parkinson's disease. (23453042)
2013
5
Vulvar skin atrophy induced by topical glucocorticoids. (22594868)
2012
6
Generation of induced pluripotent stem cells from skin fibroblasts of a patient with olivopontocerebellar atrophy. (22301348)
2012
7
Topical corticosteroids in plaque psoriasis: a systematic review of risk of adrenal axis suppression and skin atrophy. (22512680)
2012
8
Linear skin atrophy preceding calcinosis cutis in pseudo-pseudohypoparathyroidism. (22299648)
2012
9
Fluorescence spectroscopy as a tool to detect and evaluate glucocorticoid-induced skin atrophy. (22249456)
2012
10
Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging. (21679833)
2011
11
Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy. (22110776)
2011
12
Shortened treatment duration of glucocorticoid-induced skin atrophy in rats. (21824195)
2011
13
The cold hand sign in multiple system atrophy: skin perfusion revisited. (20151311)
2010
14
Identification of novel in vitro test systems for the determination of glucocorticoid receptor ligand-induced skin atrophy. (20051715)
2010
15
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. (19289104)
2009
16
Differences in skin sympathetic involvements between two chronic autonomic disorders: multiple system atrophy and pure autonomic failure. (18805037)
2009
17
A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. (19755910)
2009
18
In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle. (18246695)
2008
19
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. (19057668)
2008
20
Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. (17675581)
2007
21
Skin vasodilator response to local heating in multiple system atrophy. (17894341)
2007
22
Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans. (17123343)
2006
23
Action of topical thyroid hormone analogues on glucocorticoid-induced skin atrophy in mice. (16571090)
2006
24
Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin: a pathogenic marker. (16358333)
2006
25
Skin atrophy caused by thiocolchicoside injections. (17184273)
2006
26
Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. (17177600)
2006
27
Glucocorticoid therapy-induced skin atrophy. (16689857)
2006
28
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. (12782654)
2003
29
Topical tacrolimus and pimecrolimus are not associated with skin atrophy. (11903264)
2002
30
Dose-response effects of tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse. (12353707)
2002
31
A new autosomal recessive non-progressive congenital cerebellar ataxia associated with mental retardation, optic atrophy, and skin abnormalities (CAMOS) maps to chromosome 15q24-q26 in a large consanguineous Lebanese Druze Family. (12030328)
2002
32
Eyelid skin atrophy associated with chronic usage of ophthalmic steroid ointment, and its successful treatment with the Versapulse laser. (11702982)
2001
33
The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. (11260007)
2001
34
Comparison of skin atrophy and vasoconstriction due to mometasone furoate, methylprednisolone and hydrocortisone. (9553910)
1998
35
Skin atrophy of the eyelid induced by topical ophthalmic corticosteroids. (9686858)
1998
36
The molecular basis of glucocorticoid-induced skin atrophy: topical glucocorticoid apparently decreases both collagen synthesis and the corresponding collagen mRNA level in human skin in vivo. (9990383)
1998
37
Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. (7894098)
1995
38
In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin. (8106754)
1994
39
Morphometric computerized analysis as a method to assess skin atrophy caused by corticosteroids. (8489771)
1993
40
Combination of a dual 5-lipoxygenase/cyclooxygenase inhibitor with a glucocorticoid results in synergistic topical antiinflammatory activity without inducing skin atrophy. (8225561)
1993
41
0.25% prednicarbate cream and the corresponding vehicle induce less skin atrophy than 0.1% betamethasone-17-valerate cream and 0.05% clobetasol-17-propionate cream. (1618247)
1992
42
Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. (2768567)
1989
43
Remote skin atrophy caused by topical steroids. (21253139)
1988
44
Linear skin atrophy, scarring alopecia, anonychia, and tongue lesion: a "new" syndrome? (4040704)
1985
45
Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo. (3888708)
1985
46
Infection and prematurity as the cause of linear skin atrophy, alopecia, anonychia, and tongue lesions? (3901928)
1985
47
A study of potential skin atrophy following topical application of weak corticosteroids. (7261664)
1981
48
Comparative evaluation of skin atrophy in man induced by topical corticoids. (154921)
1979
49
Gyrate atrophy of choroid and retina: deficient activity of ornithine ketoacid aminotransferase in cultured skin fibroblasts. (917049)
1977
50
Mechanism of local skin atrophy caused by intradermally injected corticosteroids. (133836)
1976

Genetic Variations for Skin Atrophy

Expression for genes affiliated with Skin Atrophy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Atrophy

Search GEO for disease gene expression data for Skin Atrophy.

Pathways for genes affiliated with Skin Atrophy

Sources:
38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Skin Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GJA1, MMP1
29.5MMP1, NR3C1

Compounds for genes affiliated with Skin Atrophy

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 50PharmGKB
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Compounds related to Skin Atrophy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
13beta-hydroxysteroid459.7GJA1, EBP
2glycyrrhetinic acid45 2410.7NR3C1, GJA1
3ethidium bromide459.6GJA1, MMP1
4carbenoxolone29 45 1111.6GJA1, NR3C1
5progestin459.3GJA1, MMP1, NR3C1
6retinoid459.2GJA1, MMP1, NR3C1
7hydrocortisone45 2 60 1112.1MMP1, NR3C1, HAS3
8sb 20358045 609.8GJA1, MMP1, NR3C1
9vegf458.7KL, NR3C1, MMP1, GJA1
10dexamethasone45 50 29 1111.5HAS3, NR3C1, MMP1, GJA1

GO Terms for genes affiliated with Skin Atrophy

Sources:
16Gene Ontology
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Cellular components related to Skin Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.4GJA1, EIF4A1, NR3C1, FBLIM1, FERMT1, RPL13

Products for genes affiliated with Skin Atrophy

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Sources for Skin Atrophy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet