MCID: SKN005
MIFTS: 40

Skin Atrophy malady

Skin diseases category
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Summaries for Skin Atrophy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Atrophoderma refers to conditions involving skin atrophy. more...

MalaCards: Skin Atrophy, also known as atrophic condition of skin, is related to kindler syndrome and hypotrichosis. An important gene associated with Skin Atrophy is KL (klotho), and among its related pathways is Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds 3beta-hydroxysteroid and ethidium bromide have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and tongue, and related mouse phenotypes are integument and immune system.

Aliases & Classifications for Skin Atrophy

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

skin atrophy 8 10
atrophic condition of skin 8 62
atrophy - skin 8
atrophoderma 8


External Ids:

Disease Ontology8 DOID:2733
NCIt40 C35163

Related Diseases for Skin Atrophy

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17GeneCards, 18GeneDecks
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Diseases related to Skin Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1kindler syndrome29.9FERMT1
2hypotrichosis10.4
3atrophoderma of pierini and pasini10.4
4bazex-dupre-christol syndrome10.4
5basal cell carcinoma10.3
6atrophodermia vermiculata10.3
7ichthyosis, follicular10.2
8atrophoderma vermiculata10.2
9thyroiditis10.1
10hypohidrosis10.1
11ichthyosis, congenital, autosomal recessive 1110.1
12keratosis pilaris atrophicans10.1
13alopecia10.0
14multiple system atrophy10.0
15blindness10.0
16pulmonary emphysema10.0KL, MMP1
17congenital heart disease10.0GJA1, MMP1
18dilated cardiomyopathy10.0GJA1, MMP1
19melkersson-rosenthal syndrome10.0
20folliculitis10.0
21cerebritis10.0
22hypertrichosis10.0
23keratosis10.0
24lupus erythematosus10.0
25scleroderma10.0
26systemic scleroderma10.0
27basaloid follicular hamartoma10.0
28elastosis perforans serpiginosa10.0
29epidermal nevus10.0
30familial anetoderma10.0
31discoid lupus erythematosus10.0
32glaucoma10.0GJA1, MMP1
33rothmund-thomson syndrome9.9
34hallermann-streiff syndrome9.9
35calcinosis9.9
36pseudohypoparathyroidism9.9
37psoriasis9.9
38acrogeria, gottron type9.9
39cutis marmorata telangiectatica congenita9.9
40flynn aird syndrome9.9
41hyperkeratosis lenticularis perstans9.9
42porokeratosis of mibelli9.9
43porokeratosis plantaris palmaris et disseminata9.9
44rombo syndrome9.9
45sequeiros sack syndrome9.9
46spinocerebellar ataxia autosomal recessive 59.9
47van bogaert-hozay syndrome9.9
48porokeratosis 3, disseminated superficial actinic9.9
49xeroderma pigmentosum, group d9.9
50linear atrophoderma of moulin9.9

Graphical network of the top 20 diseases related to Skin Atrophy:



Diseases related to skin atrophy

Symptoms for Skin Atrophy

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Drugs & Therapeutics for Skin Atrophy

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Skin Atrophy

Search NIH Clinical Center for Skin Atrophy

Genetic Tests for Skin Atrophy

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Anatomical Context for Skin Atrophy

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33MalaCards
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MalaCards organs/tissues related to Skin Atrophy:

33
Skin, Thyroid, Tongue, Testes

Animal Models for Skin Atrophy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Skin Atrophy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9KL, GJA1, FERMT1, EBP
2MP:00053878.1KL, GJA1, MMP1, FERMT1, FBLIM1

Publications for Skin Atrophy

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52PubMed
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Articles related to Skin Atrophy:

(show all 38)
idTitleAuthorsYear
1
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. (23242470)
2013
2
Vulvar skin atrophy induced by topical glucocorticoids. (22594868)
2012
3
Topical corticosteroids in plaque psoriasis: a systematic review of risk of adrenal axis suppression and skin atrophy. (22512680)
2012
4
Linear skin atrophy preceding calcinosis cutis in pseudo-pseudohypoparathyroidism. (22299648)
2012
5
Fluorescence spectroscopy as a tool to detect and evaluate glucocorticoid-induced skin atrophy. (22249456)
2012
6
Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging. (21679833)
2011
7
Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy. (22110776)
2011
8
Shortened treatment duration of glucocorticoid-induced skin atrophy in rats. (21824195)
2011
9
Identification of novel in vitro test systems for the determination of glucocorticoid receptor ligand-induced skin atrophy. (20051715)
2010
10
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. (19289104)
2009
11
A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. (19755910)
2009
12
In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle. (18246695)
2008
13
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. (19057668)
2008
14
Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans. (17123343)
2006
15
Action of topical thyroid hormone analogues on glucocorticoid-induced skin atrophy in mice. (16571090)
2006
16
Skin atrophy caused by thiocolchicoside injections. (17184273)
2006
17
Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. (17177600)
2006
18
Glucocorticoid therapy-induced skin atrophy. (16689857)
2006
19
Topical tacrolimus and pimecrolimus are not associated with skin atrophy. (11903264)
2002
20
Dose-response effects of tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse. (12353707)
2002
21
Eyelid skin atrophy associated with chronic usage of ophthalmic steroid ointment, and its successful treatment with the Versapulse laser. (11702982)
2001
22
The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. (11260007)
2001
23
Comparison of skin atrophy and vasoconstriction due to mometasone furoate, methylprednisolone and hydrocortisone. (9553910)
1998
24
Skin atrophy of the eyelid induced by topical ophthalmic corticosteroids. (9686858)
1998
25
The molecular basis of glucocorticoid-induced skin atrophy: topical glucocorticoid apparently decreases both collagen synthesis and the corresponding collagen mRNA level in human skin in vivo. (9990383)
1998
26
Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. (7894098)
1995
27
In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin. (8106754)
1994
28
Combination of a dual 5-lipoxygenase/cyclooxygenase inhibitor with a glucocorticoid results in synergistic topical antiinflammatory activity without inducing skin atrophy. (8225561)
1993
29
0.25% prednicarbate cream and the corresponding vehicle induce less skin atrophy than 0.1% betamethasone-17-valerate cream and 0.05% clobetasol-17-propionate cream. (1618247)
1992
30
Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. (2768567)
1989
31
Remote skin atrophy caused by topical steroids. (21253139)
1988
32
Linear skin atrophy, scarring alopecia, anonychia, and tongue lesion: a "new" syndrome? (4040704)
1985
33
Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo. (3888708)
1985
34
Infection and prematurity as the cause of linear skin atrophy, alopecia, anonychia, and tongue lesions? (3901928)
1985
35
A study of potential skin atrophy following topical application of weak corticosteroids. (7261664)
1981
36
Comparative evaluation of skin atrophy in man induced by topical corticoids. (154921)
1979
37
Periarticular perilymphatic skin atrophy after intra-articular corticosteroid injections. (671670)
1978
38
Mechanism of local skin atrophy caused by intradermally injected corticosteroids. (133836)
1976

Variations for Skin Atrophy

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Expression for genes affiliated with Skin Atrophy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Atrophy

Search GEO for disease gene expression data for Skin Atrophy.

Pathways for genes affiliated with Skin Atrophy

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Skin Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5GJA1, MMP1

Compounds for genes affiliated with Skin Atrophy

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR
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Compounds related to Skin Atrophy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
13beta-hydroxysteroid459.8GJA1, EBP
2ethidium bromide459.7GJA1, MMP1
3doxycycline45 1110.6GJA1, MMP1
4fluvastatin45 51 29 1112.6MMP1, GJA1
5prostaglandin f2alpha459.5MMP1, GJA1
6betacarotene459.4GJA1, MMP1
7glycosaminoglycan459.4MMP1, HAS3
8progestin459.2GJA1, MMP1

GO Terms for genes affiliated with Skin Atrophy

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16Gene Ontology
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Cellular components related to Skin Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7KL, GJA1, EBP, HAS3

Biological processes related to Skin Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1viral processGO:0160328.7EIF4A1, RPL13, MMP1
2cellular protein metabolic processGO:0442678.4EIF4A1, RPL13, MMP1

Products for genes affiliated with Skin Atrophy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Skin Atrophy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet