MCID: SKN005
MIFTS: 41

Skin Atrophy malady

Skin diseases category
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Summaries for Skin Atrophy

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Wikipedia:65 Atrophoderma refers to conditions involving skin atrophy. more...

MalaCards based summary: Skin Atrophy, also known as atrophic condition of skin, is related to kindler syndrome and atrophoderma vermiculata. An important gene associated with Skin Atrophy is KL (klotho), and among its related pathways is Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds 3beta-hydroxysteroid and ethidium bromide have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and tongue, and related mouse phenotypes are integument and immune system.

Aliases & Classifications for Skin Atrophy

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Skin Atrophy, Aliases & Descriptions:

Name: Skin Atrophy 8 10
Atrophic Condition of Skin 8 62
 
Atrophy - Skin 8
Atrophoderma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:2733
NCIt39 C35163

Related Diseases for Skin Atrophy

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Diseases related to Skin Atrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1kindler syndrome30.3FERMT1
2atrophoderma vermiculata10.5
3bazex-dupre-christol syndrome10.5
4hypotrichosis10.4
5atrophoderma of pierini and pasini10.4
6basal cell carcinoma10.3
7atrophodermia vermiculata10.3
8ichthyosis, follicular10.2
9thyroiditis10.1
10hypohidrosis10.1
11ichthyosis, congenital, autosomal recessive 1110.1
12pulmonary emphysema10.1KL, MMP1
13alopecia10.1
14multiple system atrophy10.1
15rothmund-thomson syndrome10.1
16blindness10.1
17systemic scleroderma10.0
18melkersson-rosenthal syndrome10.0
19folliculitis10.0
20cerebritis10.0
21hypertrichosis10.0
22keratosis10.0
23lupus erythematosus10.0
24scleroderma10.0
25basaloid follicular hamartoma10.0
26elastosis perforans serpiginosa10.0
27epidermal nevus10.0
28discoid lupus erythematosus10.0
29congenital heart disease10.0GJA1, MMP1
30hallermann-streiff syndrome9.9
31calcinosis9.9
32pseudohypoparathyroidism9.9
33psoriasis9.9
34acrogeria, gottron type9.9
35cutis marmorata telangiectatica congenita9.9
36flynn aird syndrome9.9
37hyperkeratosis lenticularis perstans9.9
38porokeratosis of mibelli9.9
39porokeratosis plantaris palmaris et disseminata9.9
40rombo syndrome9.9
41sequeiros sack syndrome9.9
42spinocerebellar ataxia autosomal recessive 59.9
43van bogaert-hozay syndrome9.9
44porokeratosis 3, disseminated superficial actinic9.9
45xeroderma pigmentosum, group d9.9
46linear atrophoderma of moulin9.9
47dilated cardiomyopathy9.8GJA1, MMP1

Graphical network of the top 20 diseases related to Skin Atrophy:



Diseases related to skin atrophy

Symptoms for Skin Atrophy

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Drugs & Therapeutics for Skin Atrophy

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Drug clinical trials:

Search ClinicalTrials for Skin Atrophy

Search NIH Clinical Center for Skin Atrophy

Genetic Tests for Skin Atrophy

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Anatomical Context for Skin Atrophy

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MalaCards organs/tissues related to Skin Atrophy:

32
Skin, Thyroid, Tongue, Testes

Animal Models for Skin Atrophy or affiliated genes

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MGI Mouse Phenotypes related to Skin Atrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9KL, GJA1, FERMT1, EBP
2MP:00053878.1KL, GJA1, MMP1, FERMT1, FBLIM1

Publications for Skin Atrophy

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Articles related to Skin Atrophy:

(show all 43)
idTitleAuthorsYear
1
Palladium and Platinum Nanoparticles Attenuate Aging-Like Skin Atrophy via Antioxidant Activity in Mice. (25333617)
2014
2
Calcipotriol counteracts betamethasone-induced decrease in extracellular matrix components related to skin atrophy. (25027750)
2014
3
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. (24488534)
2014
4
Hyalurosome gene regulation and dose-dependent restoration of skin atrophy by retinaldehyde and defined-size hyaluronate fragments in dermatoporosis. (25138066)
2014
5
Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. (25229861)
2014
6
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. (23242470)
2013
7
Vulvar skin atrophy induced by topical glucocorticoids. (22594868)
2012
8
Topical corticosteroids in plaque psoriasis: a systematic review of risk of adrenal axis suppression and skin atrophy. (22512680)
2012
9
Linear skin atrophy preceding calcinosis cutis in pseudo-pseudohypoparathyroidism. (22299648)
2012
10
Fluorescence spectroscopy as a tool to detect and evaluate glucocorticoid-induced skin atrophy. (22249456)
2012
11
Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging. (21679833)
2011
12
Shortened treatment duration of glucocorticoid-induced skin atrophy in rats. (21824195)
2011
13
Identification of novel in vitro test systems for the determination of glucocorticoid receptor ligand-induced skin atrophy. (20051715)
2010
14
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. (19289104)
2009
15
A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. (19755910)
2009
16
In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle. (18246695)
2008
17
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. (19057668)
2008
18
Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans. (17123343)
2006
19
Action of topical thyroid hormone analogues on glucocorticoid-induced skin atrophy in mice. (16571090)
2006
20
Skin atrophy caused by thiocolchicoside injections. (17184273)
2006
21
Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. (17177600)
2006
22
Glucocorticoid therapy-induced skin atrophy. (16689857)
2006
23
Topical tacrolimus and pimecrolimus are not associated with skin atrophy. (11903264)
2002
24
Dose-response effects of tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse. (12353707)
2002
25
Eyelid skin atrophy associated with chronic usage of ophthalmic steroid ointment, and its successful treatment with the Versapulse laser. (11702982)
2001
26
The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. (11260007)
2001
27
Comparison of skin atrophy and vasoconstriction due to mometasone furoate, methylprednisolone and hydrocortisone. (9553910)
1998
28
Skin atrophy of the eyelid induced by topical ophthalmic corticosteroids. (9686858)
1998
29
The molecular basis of glucocorticoid-induced skin atrophy: topical glucocorticoid apparently decreases both collagen synthesis and the corresponding collagen mRNA level in human skin in vivo. (9990383)
1998
30
Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. (7894098)
1995
31
In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin. (8106754)
1994
32
Morphometric computerized analysis as a method to assess skin atrophy caused by corticosteroids. (8489771)
1993
33
Combination of a dual 5-lipoxygenase/cyclooxygenase inhibitor with a glucocorticoid results in synergistic topical antiinflammatory activity without inducing skin atrophy. (8225561)
1993
34
0.25% prednicarbate cream and the corresponding vehicle induce less skin atrophy than 0.1% betamethasone-17-valerate cream and 0.05% clobetasol-17-propionate cream. (1618247)
1992
35
Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. (2768567)
1989
36
Remote skin atrophy caused by topical steroids. (21253139)
1988
37
Linear skin atrophy, scarring alopecia, anonychia, and tongue lesion: a "new" syndrome? (4040704)
1985
38
Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo. (3888708)
1985
39
Infection and prematurity as the cause of linear skin atrophy, alopecia, anonychia, and tongue lesions? (3901928)
1985
40
A study of potential skin atrophy following topical application of weak corticosteroids. (7261664)
1981
41
Comparative evaluation of skin atrophy in man induced by topical corticoids. (154921)
1979
42
Periarticular perilymphatic skin atrophy after intra-articular corticosteroid injections. (671670)
1978
43
Mechanism of local skin atrophy caused by intradermally injected corticosteroids. (133836)
1976

Variations for Skin Atrophy

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Expression for genes affiliated with Skin Atrophy

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Expression patterns in normal tissues for genes affiliated with Skin Atrophy

Search GEO for disease gene expression data for Skin Atrophy.

Pathways for genes affiliated with Skin Atrophy

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Pathways related to Skin Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5GJA1, MMP1

Compounds for genes affiliated with Skin Atrophy

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Sources:
44Novoseek, 11DrugBank, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Skin Atrophy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
13beta-hydroxysteroid449.8GJA1, EBP
2ethidium bromide449.7GJA1, MMP1
3doxycycline44 1110.6GJA1, MMP1
4fluvastatin44 50 28 1112.6MMP1, GJA1
5prostaglandin f2alpha449.5MMP1, GJA1
6betacarotene449.4GJA1, MMP1
7glycosaminoglycan449.4MMP1, HAS3
8progestin449.2GJA1, MMP1

GO Terms for genes affiliated with Skin Atrophy

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Cellular components related to Skin Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7KL, GJA1, EBP, HAS3

Biological processes related to Skin Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1viral processGO:0160328.7EIF4A1, RPL13, MMP1
2cellular protein metabolic processGO:0442678.4EIF4A1, RPL13, MMP1

Products for genes affiliated with Skin Atrophy

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  • Antibodies
  • Proteins
  • Lysates

Sources for Skin Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet