MCID: SKN005
MIFTS: 34

Skin Atrophy malady

Skin diseases category

Summaries for Skin Atrophy

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Wikipedia:63 Atrophoderma refers to conditions involving skin atrophy. more...

MalaCards based summary: Skin Atrophy, also known as atrophic condition of skin, is related to kindler syndrome and atrophoderma of pierini and pasini. An important gene associated with Skin Atrophy is KL (klotho), and among its related pathways is Validated transcriptional targets of AP1 family members Fra1 and Fra2. The compounds 3beta-hydroxysteroid and ethidium bromide have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and testes, and related mouse phenotypes are integument and immune system.

Aliases & Classifications for Skin Atrophy

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Skin Atrophy, Aliases & Descriptions:

Name: Skin Atrophy 9 11
Atrophic Condition of Skin 9 60
 
Atrophy - Skin 9
Atrophoderma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:2733
NCIt38 C35163

Related Diseases for Skin Atrophy

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Graphical network of the top 20 diseases related to Skin Atrophy:



Diseases related to skin atrophy

Symptoms for Skin Atrophy

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Drugs & Therapeutics for Skin Atrophy

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Drug clinical trials:

Search ClinicalTrials for Skin Atrophy

Search NIH Clinical Center for Skin Atrophy

Genetic Tests for Skin Atrophy

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Anatomical Context for Skin Atrophy

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MalaCards organs/tissues related to Skin Atrophy:

31
Skin, Thyroid, Testes, Tongue

Animal Models for Skin Atrophy or affiliated genes

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MGI Mouse Phenotypes related to Skin Atrophy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.9KL, GJA1, FERMT1, EBP
2MP:00053878.1KL, GJA1, MMP1, FERMT1, FBLIM1

Publications for Skin Atrophy

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Articles related to Skin Atrophy:

(show all 46)
idTitleAuthorsYear
1
Topical corticosteroid-induced skin atrophy: a comprehensive review. (25862024)
2015
2
Acral skin atrophy in an infant: an early clue to Kindler syndrome diagnosis. (25764106)
2015
3
Palladium and Platinum Nanoparticles Attenuate Aging-Like Skin Atrophy via Antioxidant Activity in Mice. (25333617)
2014
4
Calcipotriol counteracts betamethasone-induced decrease in extracellular matrix components related to skin atrophy. (25027750)
2014
5
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. (24488534)
2014
6
Hyalurosome gene regulation and dose-dependent restoration of skin atrophy by retinaldehyde and defined-size hyaluronate fragments in dermatoporosis. (25138066)
2014
7
Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. (25229861)
2014
8
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. (23242470)
2013
9
Vulvar skin atrophy induced by topical glucocorticoids. (22594868)
2012
10
Topical corticosteroids in plaque psoriasis: a systematic review of risk of adrenal axis suppression and skin atrophy. (22512680)
2012
11
Linear skin atrophy preceding calcinosis cutis in pseudo-pseudohypoparathyroidism. (22299648)
2012
12
Fluorescence spectroscopy as a tool to detect and evaluate glucocorticoid-induced skin atrophy. (22249456)
2012
13
Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging. (21679833)
2011
14
Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy. (22110776)
2011
15
Shortened treatment duration of glucocorticoid-induced skin atrophy in rats. (21824195)
2011
16
Identification of novel in vitro test systems for the determination of glucocorticoid receptor ligand-induced skin atrophy. (20051715)
2010
17
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. (19289104)
2009
18
A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. (19755910)
2009
19
In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle. (18246695)
2008
20
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. (19057668)
2008
21
Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans. (17123343)
2006
22
Action of topical thyroid hormone analogues on glucocorticoid-induced skin atrophy in mice. (16571090)
2006
23
Skin atrophy caused by thiocolchicoside injections. (17184273)
2006
24
Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. (17177600)
2006
25
Glucocorticoid therapy-induced skin atrophy. (16689857)
2006
26
Topical tacrolimus and pimecrolimus are not associated with skin atrophy. (11903264)
2002
27
Dose-response effects of tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse. (12353707)
2002
28
Eyelid skin atrophy associated with chronic usage of ophthalmic steroid ointment, and its successful treatment with the Versapulse laser. (11702982)
2001
29
The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. (11260007)
2001
30
Comparison of skin atrophy and vasoconstriction due to mometasone furoate, methylprednisolone and hydrocortisone. (9553910)
1998
31
Skin atrophy of the eyelid induced by topical ophthalmic corticosteroids. (9686858)
1998
32
The molecular basis of glucocorticoid-induced skin atrophy: topical glucocorticoid apparently decreases both collagen synthesis and the corresponding collagen mRNA level in human skin in vivo. (9990383)
1998
33
Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. (7894098)
1995
34
In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin. (8106754)
1994
35
Morphometric computerized analysis as a method to assess skin atrophy caused by corticosteroids. (8489771)
1993
36
Combination of a dual 5-lipoxygenase/cyclooxygenase inhibitor with a glucocorticoid results in synergistic topical antiinflammatory activity without inducing skin atrophy. (8225561)
1993
37
0.25% prednicarbate cream and the corresponding vehicle induce less skin atrophy than 0.1% betamethasone-17-valerate cream and 0.05% clobetasol-17-propionate cream. (1618247)
1992
38
Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. (2768567)
1989
39
Remote skin atrophy caused by topical steroids. (21253139)
1988
40
Linear skin atrophy, scarring alopecia, anonychia, and tongue lesion: a "new" syndrome? (4040704)
1985
41
Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo. (3888708)
1985
42
Infection and prematurity as the cause of linear skin atrophy, alopecia, anonychia, and tongue lesions? (3901928)
1985
43
A study of potential skin atrophy following topical application of weak corticosteroids. (7261664)
1981
44
Comparative evaluation of skin atrophy in man induced by topical corticoids. (154921)
1979
45
Periarticular perilymphatic skin atrophy after intra-articular corticosteroid injections. (671670)
1978
46
Mechanism of local skin atrophy caused by intradermally injected corticosteroids. (133836)
1976

Variations for Skin Atrophy

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Expression for genes affiliated with Skin Atrophy

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Search GEO for disease gene expression data for Skin Atrophy.

Pathways for genes affiliated with Skin Atrophy

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Pathways related to Skin Atrophy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5GJA1, MMP1

Compounds for genes affiliated with Skin Atrophy

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Sources:
43Novoseek, 12DrugBank, 49PharmGKB, 28IUPHAR
See all sources

Compounds related to Skin Atrophy according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
13beta-hydroxysteroid439.8GJA1, EBP
2ethidium bromide439.7MMP1, GJA1
3doxycycline43 1210.6GJA1, MMP1
4fluvastatin43 49 28 1212.6MMP1, GJA1
5prostaglandin f2alpha439.5MMP1, GJA1
6betacarotene439.4GJA1, MMP1
7glycosaminoglycan439.4HAS3, MMP1
8progestin439.2MMP1, GJA1

GO Terms for genes affiliated with Skin Atrophy

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Cellular components related to Skin Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.7KL, GJA1, EBP, HAS3

Biological processes related to Skin Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1viral processGO:00160328.7EIF4A1, RPL13, MMP1
2cellular protein metabolic processGO:00442678.4EIF4A1, RPL13, MMP1

Products for genes affiliated with Skin Atrophy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Skin Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet