Aliases & Classifications for Skin Atrophy

MalaCards integrated aliases for Skin Atrophy:

Name: Skin Atrophy 12 14
Atrophic Condition of Skin 12 69
Atrophoderma 12 72
Atrophy - Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2733
ICD10 32 L90 L90.9
NCIt 46 C35163
UMLS 69 C0151514

Summaries for Skin Atrophy

MalaCards based summary : Skin Atrophy, also known as atrophic condition of skin, is related to kindler syndrome and atrophoderma vermiculata. An important gene associated with Skin Atrophy is FERMT1 (Fermitin Family Member 1), and among its related pathways/superpathways are Adhesion and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Tacrolimus and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related phenotypes are cellular and growth/size/body region

Wikipedia : 72 Atrophoderma refers to conditions involving skin... more...

Related Diseases for Skin Atrophy

Graphical network of the top 20 diseases related to Skin Atrophy:



Diseases related to Skin Atrophy

Symptoms & Phenotypes for Skin Atrophy

MGI Mouse Phenotypes related to Skin Atrophy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.87 SAT1 TCOF1 CD44 FBLIM1 FERMT1 GJA1
2 growth/size/body region MP:0005378 9.86 SAT1 TCOF1 CD44 EBP FERMT1 GJA1
3 integument MP:0010771 9.63 CD44 EBP FERMT1 GJA1 HBEGF KL
4 respiratory system MP:0005388 9.35 TCOF1 CD44 GJA1 HBEGF KL
5 skeleton MP:0005390 9.1 TCOF1 CD44 FBLIM1 GJA1 HBEGF KL

Drugs & Therapeutics for Skin Atrophy

Drugs for Skin Atrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3
Pimecrolimus Approved, Investigational Phase 4 137071-32-0 17753757 6447131
4
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4 67-73-2 6215
5
Hydroquinone Approved, Investigational Phase 4 123-31-9 785
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7 Racepinephrine Approved Phase 4 329-65-7
8
Clobetasol Approved, Investigational Phase 4,Phase 3,Phase 1 25122-41-2, 25122-46-7 5311051 32798
9
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538
10 Anti-Allergic Agents Phase 4
11 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
12 Calcineurin Inhibitors Phase 4
13 Dermatologic Agents Phase 4,Phase 1
14 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
15 mometasone furoate Phase 4
16 Peripheral Nervous System Agents Phase 4
17 glucocorticoids Phase 4,Phase 3,Phase 1
18 Hormone Antagonists Phase 4,Phase 3,Phase 1
19 Hormones Phase 4,Phase 3,Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1
21 triamcinolone acetonide Phase 4
22 Triamcinolone diacetate Phase 4
23 Triamcinolone hexacetonide Phase 4
24 Analgesics Phase 4
25 Analgesics, Non-Narcotic Phase 4
26 Anti-Inflammatory Agents, Non-Steroidal Phase 4
27 Antirheumatic Agents Phase 4
28 Antioxidants Phase 4
29 Keratolytic Agents Phase 4
30 Protective Agents Phase 4
31 Radiation-Protective Agents Phase 4
32 Anti-Asthmatic Agents Phase 4,Phase 1
33 Autonomic Agents Phase 4
34 Bronchodilator Agents Phase 4
35 Epinephryl borate Phase 4
36
Fluticasone Phase 4 80474-14-2, 90566-53-3 22833648 62924
37 Respiratory System Agents Phase 4,Phase 1
38 EMLA Phase 4
39 Emollients Phase 4,Phase 1
40
Calcitriol Approved, Nutraceutical Phase 3 32222-06-3 5280453 134070
41 Bone Density Conservation Agents Phase 3
42 Calcium, Dietary Phase 3
43 Micronutrients Phase 3
44 Trace Elements Phase 3
45 Vasoconstrictor Agents Phase 3
46 Vitamins Phase 3
47
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
48
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
49
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 6436030 5284616
50 Anti-Bacterial Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 16)

# Name Status NCT ID Phase Drugs
1 Comparison of Efficacy and Safety of 0.1% Tacrolimus and 0.1% Mometasone Furoate for Adult Vitiligo Unknown status NCT01333410 Phase 4 tacrolimus ointment;Mometasone furoate
2 Reconstitution With Pimecrolimus Cream 1% of Steroid-damaged Skin in Adults With Atopic Dermatitis Completed NCT00367393 Phase 4 Pimecrolimus cream 1%
3 Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma Completed NCT00469183 Phase 4 Fluocinolone acetonide .1%, hydroquinone 4%, tretinoin .05%
4 Cutivate Lotion HPA Axis Pediatric Study Completed NCT00546000 Phase 4 Fluticasone propionate 0.05% lotion
5 Comparison of Efficacy of Intralesional Triamcinolone Injection and Clobetasol Propionate Ointment for Psoriatic Nails Completed NCT01703325 Phase 4 0.1% triamcinolone , 0.05% clobetasol propionate ointment
6 Bilateral Comparison Study of Elidel 1% and Hylatopic Plus Emollient Foam for the Treatment of Subjects With Atopic Dermatitis Completed NCT01202149 Phase 4
7 Safety and Efficacy of Pimecrolimus Cream 1% in Mild to Moderate Head and Neck Atopic Dermatitis (AD) Patients Completed NCT00121316 Phase 4 Pimecrolimus;Placebo
8 Safety & Effectiveness of Clobex Spray, Followed by Calcitriol Ointment in Management of Plaque Psoriasis Completed NCT00658788 Phase 3 clobetasol propionate spray 0.05%;calcitriol ointment
9 Efficacy, Tolerability and Safety of LAS41004 Formulations in a Psoriasis Plaque Test Completed NCT02111499 Phase 1, Phase 2 LAS41004-IMP1;LAS41004 IMP2;LAS41004 IMP3;LAS41004 IMP4;LAS41004 IMP6;LAS41004 IMP5
10 Novel Compositions for Treating or Preventing Dermal Disorders Recruiting NCT03103893 Phase 1, Phase 2 Rapamycin
11 A Single-Centre Clinical Trial to Assess Steroid Induced Skin Atrophy on Healthy Skin Completed NCT02355639 Phase 1 Clobetasol propionate 0.05 % ointment;Betamethasone dipropionate 0.064 % ointment;Petrolatum ointment
12 A Clinical Trial to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin Completed NCT02392130 Phase 1 Clobetasol propionate 0.05% ointment;LEO 130852A gel 1%;LEO 130852A placebo gel
13 A Study Assessing GW870086's Potential to Cause Skin Thinning Completed NCT01381445 Phase 1 GW870086 0.2%;GW870086 2%;Clobetasol Propionate;Placebo
14 The Comparison Study of Intralesional Botulinum Toxin A and Corticosteroid Injection for Alopecia Areata Unknown status NCT00999869 Botulinum toxin type A;Triamcinolone acetonide
15 Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of Aging Completed NCT00974480 Tretinoin (Rejuva-A)
16 Nonneoplastic Epithelial Disorders of Vulva and High Intensity Focused Ultrasound Recruiting NCT02890277 Fu Tiankang disposable vaginal filling suppository, Albothyl (Policresulen Solution) , and the gynecologic medical antimicrobial dressing gel (chitosan gel).

Search NIH Clinical Center for Skin Atrophy

Genetic Tests for Skin Atrophy

Anatomical Context for Skin Atrophy

MalaCards organs/tissues related to Skin Atrophy:

38
Skin, Testes, Bone, Thyroid, Tongue

Publications for Skin Atrophy

Articles related to Skin Atrophy:

(show top 50) (show all 51)
# Title Authors Year
1
Mineralocorticoid receptor blockade improves glucocorticoid-induced skin atrophy but partially ameliorates anti-inflammatory actions in an irritative model in human skin explants. ( 29178328 )
2018
2
Intralesional Treatment With 5-Fluorouracil and Steroid Improves Allergic Contact Dermatitis Without Causing Skin Atrophy and Rebound Lesions. ( 28338541 )
2017
3
Annular Plaques With Skin Atrophy in a Young Patient. ( 28122082 )
2017
4
Surgical Answer to Intralesional Steroid-Induced Skin Atrophy. ( 27870650 )
2016
5
Resveratrol Derivative-Rich Melinjo Seed Extract Attenuates Skin Atrophy in Sod1-Deficient Mice. ( 26180586 )
2015
6
Acral skin atrophy in an infant: an early clue to Kindler syndrome diagnosis. ( 25764106 )
2015
7
Topical corticosteroid-induced skin atrophy: a comprehensive review. ( 25862024 )
2015
8
Hyalurosome gene regulation and dose-dependent restoration of skin atrophy by retinaldehyde and defined-size hyaluronate fragments in dermatoporosis. ( 25138066 )
2014
9
Calcipotriol counteracts betamethasone-induced decrease in extracellular matrix components related to skin atrophy. ( 25027750 )
2014
10
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. ( 24488534 )
2014
11
Palladium and Platinum Nanoparticles Attenuate Aging-Like Skin Atrophy via Antioxidant Activity in Mice. ( 25333617 )
2014
12
Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice. ( 25229861 )
2014
13
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. ( 23242470 )
2013
14
Linear skin atrophy preceding calcinosis cutis in pseudo-pseudohypoparathyroidism. ( 22299648 )
2012
15
Fluorescence spectroscopy as a tool to detect and evaluate glucocorticoid-induced skin atrophy. ( 22249456 )
2012
16
Vulvar skin atrophy induced by topical glucocorticoids. ( 22594868 )
2012
17
Topical corticosteroids in plaque psoriasis: a systematic review of risk of adrenal axis suppression and skin atrophy. ( 22512680 )
2012
18
Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging. ( 21679833 )
2011
19
Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy. ( 22110776 )
2011
20
Shortened treatment duration of glucocorticoid-induced skin atrophy in rats. ( 21824195 )
2011
21
Identification of novel in vitro test systems for the determination of glucocorticoid receptor ligand-induced skin atrophy. ( 20051715 )
2010
22
A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. ( 19755910 )
2009
23
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. ( 19289104 )
2009
24
In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle. ( 18246695 )
2008
25
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. ( 19057668 )
2008
26
Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans. ( 17123343 )
2006
27
Skin atrophy caused by thiocolchicoside injections. ( 17184273 )
2006
28
Action of topical thyroid hormone analogues on glucocorticoid-induced skin atrophy in mice. ( 16571090 )
2006
29
Glucocorticoid therapy-induced skin atrophy. ( 16689857 )
2006
30
Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. ( 17177600 )
2006
31
Topical tacrolimus and pimecrolimus are not associated with skin atrophy. ( 11903264 )
2002
32
Dose-response effects of tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse. ( 12353707 )
2002
33
The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. ( 11260007 )
2001
34
Eyelid skin atrophy associated with chronic usage of ophthalmic steroid ointment, and its successful treatment with the Versapulse laser. ( 11702982 )
2001
35
The molecular basis of glucocorticoid-induced skin atrophy: topical glucocorticoid apparently decreases both collagen synthesis and the corresponding collagen mRNA level in human skin in vivo. ( 9990383 )
1998
36
Comparison of skin atrophy and vasoconstriction due to mometasone furoate, methylprednisolone and hydrocortisone. ( 9553910 )
1998
37
Skin atrophy of the eyelid induced by topical ophthalmic corticosteroids. ( 9686858 )
1998
38
Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. ( 7894098 )
1995
39
In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin. ( 8106754 )
1994
40
Morphometric computerized analysis as a method to assess skin atrophy caused by corticosteroids. ( 8489771 )
1993
41
Combination of a dual 5-lipoxygenase/cyclooxygenase inhibitor with a glucocorticoid results in synergistic topical antiinflammatory activity without inducing skin atrophy. ( 8225561 )
1993
42
0.25% prednicarbate cream and the corresponding vehicle induce less skin atrophy than 0.1% betamethasone-17-valerate cream and 0.05% clobetasol-17-propionate cream. ( 1618247 )
1992
43
Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. ( 2768567 )
1989
44
Remote skin atrophy caused by topical steroids. ( 21253139 )
1988
45
Linear skin atrophy, scarring alopecia, anonychia, and tongue lesion: a "new" syndrome? ( 4040704 )
1985
46
Infection and prematurity as the cause of linear skin atrophy, alopecia, anonychia, and tongue lesions? ( 3901928 )
1985
47
Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo. ( 3888708 )
1985
48
A study of potential skin atrophy following topical application of weak corticosteroids. ( 7261664 )
1981
49
Comparative evaluation of skin atrophy in man induced by topical corticoids. ( 154921 )
1979
50
Periarticular perilymphatic skin atrophy after intra-articular corticosteroid injections. ( 671670 )
1978

Variations for Skin Atrophy

Expression for Skin Atrophy

Search GEO for disease gene expression data for Skin Atrophy.

Pathways for Skin Atrophy

GO Terms for Skin Atrophy

Cellular components related to Skin Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 CD44 EBP GJA1 HBEGF KL
2 apical plasma membrane GO:0016324 9.33 CD44 GJA1 KL
3 focal adhesion GO:0005925 8.92 CD44 FBLIM1 FERMT1 GJA1

Biological processes related to Skin Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of heart contraction GO:0008016 8.62 GJA1 HBEGF

Molecular functions related to Skin Atrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.96 HBEGF KL
2 scaffold protein binding GO:0097110 8.62 GJA1 TCOF1

Sources for Skin Atrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....