MCID: SKN005
MIFTS: 38

Skin Atrophy malady

Skin diseases category

Summaries for Skin Atrophy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Atrophoderma refers to conditions involving skin atrophy. more...

MalaCards: Skin Atrophy, also known as atrophic condition of skin, is related to kindler syndrome and hypotrichosis. An important gene associated with Skin Atrophy is KL (klotho), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Immune response MIF-mediated glucocorticoid regulation. The compounds 3beta-hydroxysteroid and glycyrrhetinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and retina, and related mouse phenotype integument.

Aliases & Classifications for Skin Atrophy

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

skin atrophy 8 10
atrophic condition of skin 8 60
atrophy - skin 8
atrophoderma 8


External Ids:

Disease Ontology8 DOID:2733
NCIt39 C35163

Related Diseases for Skin Atrophy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Skin Atrophy:



Diseases related to skin atrophy

Clinical Features for Skin Atrophy

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Drugs & Therapeutics for Skin Atrophy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Skin Atrophy

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Anatomical Context for Skin Atrophy

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32MalaCards
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MalaCards organs/tissues related to Skin Atrophy:

32
Skin, Thyroid, Retina, Testes, Tongue, Eye, Bone, Spinal cord, Skeletal muscle

Animal Models for Skin Atrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Skin Atrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5GJA1, EBP, NR3C1, FERMT1, KL

Publications for Skin Atrophy

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50PubMed
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Articles related to Skin Atrophy:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Novel SPG10 mutation associated with dysautonomia, spinal cord atrophy, and skin biopsy abnormality. (22788249)
2013
2
Validation of Dermaphot(Ar) for the assessment of steroid-induced skin atrophy. (23242470)
2013
3
Incontinentia pigmenti: a newborn with characteristic skin lesions and bilateral optic atrophy: case report and review of literature. (24390952)
2013
4
Skin temperature of the hand in multiple system atrophy and Parkinson's disease. (23453042)
2013
5
Vulvar skin atrophy induced by topical glucocorticoids. (22594868)
2012
6
Topical corticosteroids in plaque psoriasis: a systematic review of risk of adrenal axis suppression and skin atrophy. (22512680)
2012
7
Linear skin atrophy preceding calcinosis cutis in pseudo-pseudohypoparathyroidism. (22299648)
2012
8
Fluorescence spectroscopy as a tool to detect and evaluate glucocorticoid-induced skin atrophy. (22249456)
2012
9
Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging. (21679833)
2011
10
Skin and subcutanous fat atrophy after corticosteroid injection for medial epicondylitis. (21800809)
2011
11
Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy. (22110776)
2011
12
Shortened treatment duration of glucocorticoid-induced skin atrophy in rats. (21824195)
2011
13
The cold hand sign in multiple system atrophy: skin perfusion revisited. (20151311)
2010
14
Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. (19289104)
2009
15
Differences in skin sympathetic involvements between two chronic autonomic disorders: multiple system atrophy and pure autonomic failure. (18805037)
2009
16
A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream. (19755910)
2009
17
In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle. (18246695)
2008
18
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. (19057668)
2008
19
Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. (17675581)
2007
20
Skin vasodilator response to local heating in multiple system atrophy. (17894341)
2007
21
Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans. (17123343)
2006
22
Action of topical thyroid hormone analogues on glucocorticoid-induced skin atrophy in mice. (16571090)
2006
23
Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin: a pathogenic marker. (16358333)
2006
24
Skin atrophy caused by thiocolchicoside injections. (17184273)
2006
25
Skin vasomotor reflex responses in two contrasting groups of autonomic failure: multiple system atrophy and pure autonomic failure. (16845569)
2006
26
Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. (17177600)
2006
27
Glucocorticoid therapy-induced skin atrophy. (16689857)
2006
28
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. (12782654)
2003
29
Topical tacrolimus and pimecrolimus are not associated with skin atrophy. (11903264)
2002
30
Dose-response effects of tri-iodothyroacetic acid (Triac) and other thyroid hormone analogues on glucocorticoid-induced skin atrophy in the haired mouse. (12353707)
2002
31
A new autosomal recessive non-progressive congenital cerebellar ataxia associated with mental retardation, optic atrophy, and skin abnormalities (CAMOS) maps to chromosome 15q24-q26 in a large consanguineous Lebanese Druze Family. (12030328)
2002
32
Eyelid skin atrophy associated with chronic usage of ophthalmic steroid ointment, and its successful treatment with the Versapulse laser. (11702982)
2001
33
The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study. (11260007)
2001
34
Skin atrophy of the eyelid induced by topical ophthalmic corticosteroids. (9686858)
1998
35
The molecular basis of glucocorticoid-induced skin atrophy: topical glucocorticoid apparently decreases both collagen synthesis and the corresponding collagen mRNA level in human skin in vivo. (9990383)
1998
36
Skin atrophy induced by initial continuous topical application of clobetasol followed by intermittent application. (7894098)
1995
37
In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin. (8106754)
1994
38
Morphometric computerized analysis as a method to assess skin atrophy caused by corticosteroids. (8489771)
1993
39
Combination of a dual 5-lipoxygenase/cyclooxygenase inhibitor with a glucocorticoid results in synergistic topical antiinflammatory activity without inducing skin atrophy. (8225561)
1993
40
0.25% prednicarbate cream and the corresponding vehicle induce less skin atrophy than 0.1% betamethasone-17-valerate cream and 0.05% clobetasol-17-propionate cream. (1618247)
1992
41
Topical all-trans-retinoic acid prevents corticosteroid-induced skin atrophy without abrogating the anti-inflammatory effect. (2768567)
1989
42
Remote skin atrophy caused by topical steroids. (21253139)
1988
43
Linear skin atrophy, scarring alopecia, anonychia, and tongue lesion: a "new" syndrome? (4040704)
1985
44
Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo. (3888708)
1985
45
Infection and prematurity as the cause of linear skin atrophy, alopecia, anonychia, and tongue lesions? (3901928)
1985
46
Gyrate atrophy of the choroid and retina: decreased ornithine aminotransferase concentration in cultured skin fibroblasts from patients. (6362920)
1984
47
A study of potential skin atrophy following topical application of weak corticosteroids. (7261664)
1981
48
Comparative evaluation of skin atrophy in man induced by topical corticoids. (154921)
1979
49
Periarticular perilymphatic skin atrophy after intra-articular corticosteroid injections. (671670)
1978
50
Gyrate atrophy of choroid and retina: deficient activity of ornithine ketoacid aminotransferase in cultured skin fibroblasts. (917049)
1977

Genetic Variations for Skin Atrophy

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Expression for genes affiliated with Skin Atrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Atrophy

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Pathways for genes affiliated with Skin Atrophy

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37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Skin Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GJA1, MMP1
29.5MMP1, NR3C1

Compounds for genes affiliated with Skin Atrophy

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Skin Atrophy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
13beta-hydroxysteroid449.7GJA1, EBP
2glycyrrhetinic acid44 2410.7NR3C1, GJA1
3ethidium bromide449.6GJA1, MMP1
4carbenoxolone28 44 1111.6GJA1, NR3C1
5progestin449.3GJA1, MMP1, NR3C1
6retinoid449.2GJA1, MMP1, NR3C1
7hydrocortisone44 2 59 1112.1MMP1, NR3C1, HAS3
8sb 20358044 599.8GJA1, MMP1, NR3C1
9vegf448.7KL, NR3C1, MMP1, GJA1
10dexamethasone44 49 28 1111.5HAS3, NR3C1, MMP1, GJA1

GO Terms for genes affiliated with Skin Atrophy

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16Gene Ontology
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Cellular components related to Skin Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.4GJA1, EIF4A1, NR3C1, FBLIM1, FERMT1, RPL13

Products for genes affiliated with Skin Atrophy

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  • Antibodies
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Sources for Skin Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet