Skin Cancer malady

MedlinePlus: Skin cancer is the most common form of cancer in the united states. the two most common types are basal cell cancer and squamous cell cancer. they usually form on the head, face, neck, hands and arms. another type of skin cancer, melanoma, is more dangerous but less common. anyone can get skin cancer, but it is more common in people who spend a lot of time in the sun or have been sunburned have light-colored skin, hair and eyes have a family member with skin cancer are over age 50 you should have your doctor check any suspicious skin markings and any changes in the way your skin looks. treatment is more likely to work well when cancer is found early. if not treated, some types of skin cancer cells can spread to other tissues and organs. nih: national cancer institute²³

MalaCards: Skin Cancer, also known as malignant neoplasm of skin, is related to melanoma metastasis and familial melanoma. An important gene associated with Skin Cancer is MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)), and among its related pathways are Colorectal cancer and Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1. The drugs interferon alfa 2-b and interferon alfacon-1 and the compounds glucose and benzo(a)pyrene have been mentioned in the context of this disorder. Affiliated tissues include the skin, brain and lung, and related mouse phenotypes are craniofacial and respiratory system.

Disease Ontology: An organ system cancer located in the skin that is the uncontrolled growth of abnormal skin cells.⁶

CDC: Skin cancer is the most common form of cancer in the United States. In the United States in 2008,* 59,695 people were diagnosed with melanomas of the skin, and 8,623 people died from it.† CDC leads national efforts to reduce skin cancer through education. When in the sun, seek shade, cover up, get a hat, wear sunglasses, and use sunscreen.²

Wikipedia: Skin cancers (neoplasms) are named after the type of skin cell from which they arise. Basal cell cancer...⁴⁴ more...

Aliases & Descriptions:

skin cancer 6 17 8 32 23 malignant neoplasm of skin 6 43 malignant neoplasm of skin, unspecified (disorder) 6 malignant neoplasm of skin nos (disorder) 6 melanoma and non-melanoma skin cancer 6

malignant neoplasm of skin (disorder) 6 malignant neoplasms 43 ca - skin cancer 6 melanoma 43

Diseases related to skin cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1144)

id	Related Disease	Score	Top Affiliating Genes
1	melanoma metastasis	34.9	CDKN2A, MMP14, MMP2, FGF2, MAPK1, CCND1
2	familial melanoma	34.8	CDKN2A, CDK4, ASIP, MDM2, MC1R, IFNA1
3	microphthalmia	34.2	FOS, MLANA, IRF4, MC1R, MAPK14, MAPK10
4	cutaneous malignant melanoma	34.2	PCNA, BRCA2, BIRC5, BCL2, BAX, XRCC3
5	nasopharynx carcinoma	33.7	CDKN2A, CDH1, MMP9, CCND1, CASP3, TP53
6	skin melanoma	33.5	PCNA, CDKN2A, MMP2, FGF2, IL10, CCND1
7	oral cavity cancer	33.3	BAX, GSTM1, GSTT1, MAPK14, GPX1, CAT
8	intraocular melanoma	32.6	CDKN2A, CDK4, MMP2, MLANA, MDM2, MC1R
9	salivary gland cancer	32.0	BIRC5, CHUK, CFLAR, MMP9, FAS, CASP3
10	vitiligo	32.0	VDR, BIRC5, BAX, MSH2, MLANA, ASIP
11	posterior uveal melanoma	31.9	PCNA, BIRC5, MMP9, MLANA, TYR
12	tongue cancer	31.7	PCNA, VIM, BIRC5, BCL2, BAX, CDKN2A
13	colorectal cancer	31.5	VDR, MTHFR, XRCC5, MSH2, GSTM1, GSTP1
14	parathyroid carcinoma	31.3	BRCA2, LGALS3, CCND1, TP53, TERT, KRT14
15	ovarian cancer	30.8	BRCA1, BRCA2, CDK2, CDKN2A, CDK4, CDK1
16	cardia cancer	30.6	MTHFR, XRCC1, CDKN2A, CD44, GSTM1, GSTP1
17	squamous cell carcinoma	30.4	LGALS3, CD44, CDH1, MMP10, MMP12, MMP19
18	brain cancer	30.4	BRCA2, BAX, HRAS, AKT1, PTEN, EGFR
19	oculocutaneous albinism	30.3	MC1R, TYR, TYRP1, OCA2, SLC45A2
20	vaccinia	30.2	LIG4, CHUK, BAK1, BAX, ATRN, JUN
21	xeroderma pigmentosum, group c	30.1	XPC, CDKN2A, MC1R, ERCC3, ERCC5, ERCC8
22	kidney cancer	30.1	PIK3CA, CD44, FHIT, GSTP1, FGF2, IFNA1
23	thoracic cancer	30.1	CASP3, CASP8, CASP9, TNFSF10, PTGS2
24	skin carcinoma	30.0	CDK4, CDH1, IVL, MMP2, GSTM1, GSTP1
25	pancreatic ductal carcinoma	30.0	CDK2, CDKN2A, MMP9, TP53, NOS2, KRT7
26	pancreatic cancer	29.9	BRCA2, BIRC5, LGALS3, BAK1, CDK2, CDX2
27	basal cell carcinoma	29.7	PIP, PI3, VDR, BCAM, BCL2, LGALS3
28	stomach carcinoma	29.4	CDKN2A, CD44, CDH1, FAS, CCND1, ABCB1
29	prostate carcinoma	29.3	BRCA2, VDR, MTHFR, CDH1, MMP9, GSTM1
30	spiradenoma	29.0	TP53, CYLD, KRT7, KRT15, KRT14
31	male breast cancer	29.0	PCNA, BRCA1, BRCA2, APOD, TP53, PTEN
32	diffuse gastric cancer	28.9	XRCC3, CDH3, CDH1, GSTM1, GSTP1, GSTT1
33	renal cell carcinoma	28.9	PIK3CA, PCNA, VIM, BIRC5, CHKA, BAK1
34	parkinson's disease	28.8	CNR1, BAX, GSTA4, MAPK8, MAPK3, MAPK14
35	non-hodgkin lymphoma	28.7	CNR2, VDR, BMI1, BIRC5, BCL2, CHUK
36	xeroderma pigmentosum	28.6	PCNA, BRCA1, LIG4, BCL2, BAX, XRCC1
37	nevoid basal cell carcinoma syndrome	28.5	PCNA, XPA, MMP3, GSTM1, MC1R, FANCC
38	malignant peripheral nerve sheath tumor	28.4	VIM, CDKN2A, CDK4, MDM2, TERT, NOS2
39	large cell carcinoma	28.3	BCL2, BAK1, BAX, S100A7, IGF1, TP53
40	urinary bladder cancer	28.3	BIRC5, CDK2, CDKN2A, CDH1, GSTM1, GSTT1
41	familial pancreatic cancer	28.3	BRCA1, BRCA2, YES1, CDKN2A, FANCC, ERBB3
42	acute lymphoblastic leukemia	28.2	BCL2, CHUK, MTHFR, XRCC1, MSH2, JUN
43	familial colorectal cancer	28.2	PIK3CA, VDR, BCL2, BAK1, MSH2, CDKN2A
44	hodgkin's lymphoma	28.0	BRCA1, BRCA2, BMI1, BCL2, CHUK, CFLAR
45	choroiditis	27.9	PCNA, VIM, BIRC5, BCL2, MTHFR, CDX2
46	dna topoisomerase i	27.9	XRCC5, JUN, CDKN2A, CDK4, FGF2, F3
47	t-cell leukemia	27.9	BIRC5, BCL2, LGALS3, CHUK, ATF3, FYN
48	mixed cell type cancer	27.9	PIP, VIM, TP53, KRT7, KRT14
49	immunodeficiency	27.9	CFLAR, CDKN3, GZMB, IL10, FASLG, FAS
50	fanconi's anemia	27.8	PCNA, BRCA1, BRCA2, LIG4, BCL2, CHUK

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 aldesleukin, bleomycin, bleomycin sulfate, carmustine, dacarbazine, dactinomycin, docetaxel, hydroxyurea, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, lomustine, peginterferon alfa-2a, peginterferon alfa-2b, procarbazine, procarbazine hydrochloride, temozolomide

MalaCards organs/tissues related to skin cancer:

²²

FMA organs/tissues related to skin cancer:

¹¹

MGI Mouse Phenotypes related to skin cancer:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	11.0	BMI1, LIG4, XRCC2, XPA, ASIP, FGFR2
2	respiratory system phenotype	MP:0005388	10.6	BRCA1, LIF, HPRT1, PTGER4, DICER1, CYLD
3	endocrine/exocrine gland phenotype	MP:0005379	10.2	BRCA1, BRCA2, MYT1, KDM5A, XPA, ATF3
4	other phenotype	MP:0005395	10.0	CNR1, CDKN2A, MMP14, ASIP, PTGS2, PTGS1
5	hematopoietic system phenotype	MP:0005397	10.0	PCNA, BRCA1, BRCA2, BMI1, LIG4, LITAF
6	renal/urinary system phenotype	MP:0005367	9.8	BRCA1, BCAM, BCL2, CHUK, BAK1, BAX
7	liver/biliary system phenotype	MP:0005370	9.7	LIG4, LIF, CHKA, CEBPA, ASIP, FANCC
8	immune system phenotype	MP:0005387	9.6	CNR2, VIM, BRCA1, BRCA2, VDR, BMI1
9	mortality/aging	MP:0010768	9.3	PIK3CA, CNR1, BRCA1, BRCA2, VDR, MYT1
10	pigmentation phenotype	MP:0001186	9.2	BRCA1, BCL2, XPA, ATRN, CDKN2A, ASIP
11	no phenotypic analysis	MP:0003012	9.2	CNR1, PCNA, KDM5B, MTHFR, CEBPA, FYN
12	embryogenesis phenotype	MP:0005380	9.0	PIK3CA, VIM, BRCA1, BRCA2, BMI1, BIRC5
13	adipose tissue phenotype	MP:0005375	8.8	PIK3CA, CNR1, BRCA1, LIF, BCL2, XPA
14	integument phenotype	MP:0010771	8.7	CNR1, CNR2, BRCA1, BRCA2, LIF, BCL2
15	hearing/vestibular/ear phenotype	MP:0005377	8.7	VDR, BCL2, CHUK, BAK1, BAX, P2RX7
16	behavior/neurological phenotype	MP:0005386	8.6	PIK3CA, CNR1, VIM, BRCA2, BMI1, LIG4
17	normal phenotype	MP:0002873	8.6	BRCA1, BRCA2, KDM5A, BCAM, BAK1, YES1
18	reproductive system phenotype	MP:0005389	8.5	PIK3CA, BRCA1, BRCA2, VDR, LIG4, LIF
19	growth/size phenotype	MP:0005378	8.3	PIK3CA, CNR1, BRCA1, BRCA2, VDR, BMI1
20	limbs/digits/tail phenotype	MP:0005371	8.3	BRCA1, BRCA2, VDR, BMI1, CHUK, BAK1
21	digestive/alimentary phenotype	MP:0005381	8.3	BRCA1, BRCA2, VDR, BMI1, LIG4, LIF
22	nervous system phenotype	MP:0003631	8.1	CNR1, BRCA1, BMI1, LIF, LITAF, BCAM
23	tumorigenesis	MP:0002006	7.9	PIK3CA, BRCA1, BRCA2, BMI1, LIG4, KDM5A
24	skeleton phenotype	MP:0005390	7.2	CNR1, BRCA1, BRCA2, VDR, BMI1, LIF
25	vision/eye phenotype	MP:0005391	7.0	PIK3CA, VIM, BMI1, LIF, BCL2, CHUK
26	muscle phenotype	MP:0005369	6.8	PIK3CA, VIM, BRCA1, MYT1, LIF, BCL2
27	homeostasis/metabolism phenotype	MP:0005376	6.7	PIK3CA, CNR1, VIM, BRCA1, BRCA2, VDR
28	cardiovascular system phenotype	MP:0005385	6.4	PIK3CA, VIM, BRCA1, VDR, BMI1, LIF
29	cellular phenotype	MP:0005384	5.9	PIK3CA, CNR1, PCNA, VIM, BRCA1, BRCA2

Articles related to skin cancer:

(show top 50)    (show all 221)

id	Title	Authors	Year	Affiliating Genes
1	TP53 Arg72Pro Polymorphism and Skin Cancer Risk: A Me ta-Analysis. (20861852)	Jiang D.K.... Yu L.	2011	TP53
2	CYLD regulates keratinocyte differentiation and skin cancer progression in humans. (21900959)	Alameda J.P.... Casanova M.L.	2011	CYLD
3	TIG3 tumor suppressor-dependent organelle redistribut ion and apoptosis in skin cancer cells. (21858038)	Scharadin T.M.... Eckert R.L.	2011	RARRES3
4	BRCA1 and BRCA2 families and the risk of skin cancer. (20809262)	Ginsburg O.M.... Narod S.A.	2010	BRCA1, BRCA2
5	Association between basal, squamous cell carcinomas, dysplastic nevi and myotonic muscular dystrophy indicates an important role of RNA-binding proteins in development of human skin cancer. (19902230)	Zemtsov A.	2010	SUGP1
6	Genetic variants in the 53BP1 gene and skin cancer ri sk. (20686496)	He C.... Han J.	2010	TP53BP1
7	Polymorphisms in genes involved in oxidative stress a nd their interactions with lifestyle factors on skin cancer risk. (20727719)	He C.... Han J.	2010	CAT, GPX1
8	A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects w ith previous history of skin cancer. (20051371)	Bailey H.H.... Carbone P.P.	2010	ODC1
9	Role of matriptase and proteinase-activated receptor- 2 in nonmelanoma skin cancer. (19242518)	Bocheva G.... Steinhoff M.	2009	ST14, F2RL1, SPINT1
10	Immunohistochemical detection of p53 protein in basal cell skin cancer after microwave-assisted antigen retrieval. (19096907)	Evke E.... Kahveci Z.	2009	TP53
11	Characterization CSMD1 in a large set of primary lung , head and neck, breast and skin cancer tissues. (19276661)	Ma C.... Brose M.S.	2009	CSMD1
12	Innovative 19-minute rapid cytokeratin immunostaining of nonmelanoma skin cancer in Mohs micrographic surgery. (19469800)	Cherpelis B.S.... Fenske N.A.	2009	CHKA
13	Myricetin suppresses UVB-induced skin cancer by targeting Fyn. (18632659)	Jung S.K.... Dong Z.	2008	FYN
14	The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. (18483286)	Zheng D.... Dong Z.	2008	CNR1, CNR2
15	High numbers of human skin cancers express MMP2 and several integrin genes. (18251742)	Orimoto A.M.... Ruiz I.R.	2008	MMP2
16	Involvement of interleukin-10 promoter polymorphisms in nonmelanoma skin cancers-a case study in non-Caucasian skin cancer patients. (18173702)	Nagano T.... Nishigori C.	2008	IL10
17	Targeting mutant p53 shows promise for sunscreens and skin cancer. (18060027)	El-Deiry W.S.	2007	TP53
18	Apoptosis pathways as promising targets for skin cancer therapy. (17488402)	Eberle J.... Stockfleth E.	2007	GZMB
19	Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer. (17392827)	Patel A.S.... Nelson H.H.	2007	NR3C1
20	Sunlight and skin cancer: lessons from the immune system. (17443748)	Ullrich S.E.	2007	HTR3A
21	Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression. (18042068)	O'Grady A.... Kay E.	2007	MMP2, MMP9, TIMP2
22	Manganese superoxide dismutase polymorphism and risk of skin cancer (United States). (17186424)	Han J.... Hunter D.J.	2007	SOD2
23	Polymorphisms in the MTHFR and VDR genes and skin cancer risk. (16950800)	Han J.... Hunter D.J.	2007	VDR, MTHFR, CDX2
24	Expression and heterodimer-binding activity of Ku70 and Ku80 in human non-melanoma skin cancer. (16497868)	Parrella P.... Fazio V.M.	2006	XRCC6, XRCC5
25	A novel complex insertion/deletion mutation in the XPC DNA repair gene leads to skin cancer in an Iraqi family. (16794584)	Emmert S.... Kraemer K.H.	2006	XPC
26	Expression of stromal cell markers in distinct compartments of human skin cancers. (16420310)	Huber M.A.... Garin-Chesa P.	2006	FAP, CD248, MMRN2
27	Protein kinase Cepsilon and development of squamous c ell carcinoma, the nonmelanoma human skin cancer. (16683253)	Verma A.K.... Manoharan H.	2006	DYT10
28	Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk. (15972726)	Beaumont K.A.... Sturm R.A.	2005	MC1R
29	Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. (16185283)	Lee J.L.... Athar M.	2005	PTGS2, PTGER4, PTGER1
30	Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice. (15169894)	Pendas A.M.... Lopez-Otin C.	2004	MMP19
31	Does the addition of information on genotype improve prediction of the risk of melanoma and nonmelanoma skin cancer beyond that obtained from skin phenotype? (15105175)	Dwyer T.... Sale M.M.	2004	MC1R
32	Genetic variation in XRCC1, sun exposure, and risk of skin cancer. (15381933)	Han J.... Hunter D.J.	2004	XRCC1
33	Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan. (12635827)	Chen Y.C.... Christiani D.C.	2003	TP53
34	Mutations of Fas (APO-1/CD95) and p53 genes in nonmelanoma skin cancer. (12447615)	Boldrini L.... Fontanini G.	2003	FAS
35	Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer. (12164929)	McGregor J.M.... Crook T.	2002	TP53
36	Double jeopardy: Ras and CDK4 co-expression in skin cancer. (12470986)	Edmunds S.C.... Kelsell D.P.	2002	CDK4
37	Coexpression patterns of EGFR, HER2, HER3 and HER4 in non-melanoma skin cancer. (11166154)	Krahn G.... Peter R.U.	2001	ERBB4, ERBB3
38	Leukaemia inhibitory factor and interleukin-8 expression in nonmelanoma skin cancers. (11260184)	Szepietowski J.C.... McKenzie R.C.	2001	LIF
39	p53 mutations experimentally induced by 8-methoxypsoralen plus UVA (PUVA) differ from those found in human skin cancers in PUVA-treated patients. (10719037)	Monti P.... Fronza G.	2000	PAICS
40	The role of PUVA in the treatment of psoriasis. Photobiology issues related to skin cancer incidence. (11702610)	Gasparro F.P.	2000	TP53
41	Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer. (10844553)	Kerkela E.... Saarialho-Kere U.	2000	MMP12
42	Modulation of mitogen-activated protein kinase activa tion and cell cycle regulators by the potent skin cancer preventive agent silym arin. (10491326)	Zi X.... Agarwal R.	1999	EGFR, MAPK1
43	COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. (9635856)	Buckman S.Y.... Pentland A.P.	1998	PTGS2
44	Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression. (9642119)	Ahmad N.... Agarwal R.	1998	EGFR, SHC1
45	E- and P-cadherin expression in tumor tissues and soluble E-cadherin levels in sera of patients with skin cancer. (8902651)	Shirahama S.... Takigawa M.	1996	CDH1, CDH3
46	Infrequent alterations of the p53 gene in rat skin cancers induced by ionizing radiation. (8625503)	Jin Y.... Hosselet S.	1996	TP53
47	p53 gene mutations in skin cancers with underlying disorders. (8664219)	Kanekura T.... Maruyama I.	1995	TP53
48	Posttransplant skin cancer: a possible role for p53 gene mutation but not for oncogenic human papillomaviruses. (8176007)	McGregor J.M.... Macdonald D.M.	1994	TP53
49	p53 gene mutations in human epithelial skin cancers. (8437842)	MolA"s J.P.... Basset-SA"guin N.	1993	TP53
50	The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer. (8336934)	Tornaletti S.... Pfeifer G.P.	1993	TP53

Genes related to skin cancer according to GeneCards:

(show top 50)    (show all 228)

id	Symbol	Description	Score	GeneCards Section Context
1	MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	11.0	UniProt Related, Publications, Summaries
2	DDB2	damage-specific DNA binding protein 2, 48kDa	11.0	Publications, Summaries
3	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	11.0	Summaries
4	MMP19	matrix metallopeptidase 19	11.0	Publications
5	ASIP	agouti signaling protein	11.0	Publications
6	XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	11.0	Publications
7	ERCC2	excision repair cross-complementing rodent repair deficiency, complementation group 2	11.0	Functions, Publications
8	XPC	xeroderma pigmentosum, complementation group C	11.0	Publications
9	POLH	polymerase (DNA directed), eta	11.0
10	TYRP1	tyrosinase-related protein 1	11.0	Publications
11	MMP10	matrix metallopeptidase 10 (stromelysin 2)	11.0	Publications
12	S100A7	S100 calcium binding protein A7	11.0
13	PI3	peptidase inhibitor 3, skin-derived	11.0
14	MMP12	matrix metallopeptidase 12 (macrophage elastase)	11.0	Publications
15	PTCH1	patched 1	11.0	Publications
16	MAPK9	mitogen-activated protein kinase 9	11.0	Publications
17	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	11.0	Publications
18	TERC	telomerase RNA component	11.0	Publications
19	CHKA	choline kinase alpha	11.0	Publications
20	TP53	tumor protein p53	11.0	Publications
21	APRT	adenine phosphoribosyltransferase	11.0
22	XPA	xeroderma pigmentosum, complementation group A	11.0	Publications
23	RARS	arginyl-tRNA synthetase	11.0
24	ERCC3	excision repair cross-complementing rodent repair deficiency, complementation group 3	11.0
25	CFLAR	CASP8 and FADD-like apoptosis regulator	11.0
26	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
27	CDK4	cyclin-dependent kinase 4	11.0	Publications
28	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
29	CHUK	conserved helix-loop-helix ubiquitous kinase	11.0	Publications
30	SSBP3	single stranded DNA binding protein 3	11.0
31	TYR	tyrosinase (oculocutaneous albinism IA)	11.0	Publications
32	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0
33	OGG1	8-oxoguanine DNA glycosylase	11.0
34	ODC1	ornithine decarboxylase 1	11.0	Publications
35	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
36	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
37	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications
38	FOS	FBJ murine osteosarcoma viral oncogene homolog	11.0	Publications
39	AKT3	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	11.0
40	MAPK8	mitogen-activated protein kinase 8	11.0	Publications
41	JUN	jun proto-oncogene	11.0	Publications
42	CAT	catalase	11.0	Publications
43	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
44	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
45	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0
46	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0
47	POMC	proopiomelanocortin	11.0	Publications
48	MAPK1	mitogen-activated protein kinase 1	11.0	Publications
49	MAPK14	mitogen-activated protein kinase 14	11.0
50	FHIT	fragile histidine triad	11.0	Publications

Pathways related to skin cancer according to GeneDecks:

(show top 50)    (show all 420)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	11.0	SMAD2, AKT3, CASP9, MAPK9, MAPK8, FOS
2	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	10.9	MAPK9
3	Pancreatic cancer20	10.7	AKT3, BRCA2
4	UVA-Induced MAPK Signaling36	10.7	RRAS2, PRKCA, EGFR, CYCS, TP53, HRAS
5	EGFR Inhibitor Pathway, Pharmacodynamics34	10.7	HRAS
6	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	10.5	PRKCA, CYCS, AKT3, AKT1, MAPK9, MAPK3
7	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.5	CYCS, ERBB3, AKT3, CASP9, BCL2
8	DNA Repair Mechanisms36	10.4	TP53, ERCC6, ERCC4, ERCC1, ERCC5, ERCC3
9	Transcription P53 signaling pathway10	10.3	TP53, MAPK9, MAPK10, MAPK8, GTF2H5, CDKN2A
10	Transcription_P53 signaling pathway41	10.2	TP53, ERCC3, ERCC2, MAPK9, MAPK10, MAPK8
11	Signal transduction_PTEN pathway41	10.1	CASP9, IGF1R, PCNA
12	p53 Signaling36	10.0	MAPK8, MDM2, FOS, CDK4, BAX, BCL2
13	Cell Cycle / Checkpoint Control3	10.0	PKMYT1, XRCC6, XRCC5, XRCC1, BRCA2, BRCA1
14	UVC-Induced MAPK Signaling36	9.9	RRAS2, PRKCA, EGFR, SRC, TP53, HRAS
15	ErbB Family Pathway36	9.9	MAPK8, FOS, JUN, MAPK3, MAPK14, RRAS2
16	Chagas disease (American trypanosomiasis)20	9.9	TLR4, NOS2, SMAD2, CHUK, PIK3CA, CFLAR
17	p53 signaling pathway20	9.9	CYCS, DDB2, PTEN, TP53, CASP9, CASP8
18	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.7	BCL2, PIK3CA, BAX, JUN, SHC1, CYCS
19	Toxoplasmosis20	9.5	CASP9, CASP8, CASP3, MAPK9, MAPK1, MAPK10
20	Akt Signaling36	9.3	CCND1, MDM2, IL10, FGF7, CHUK, LIF
21	Glioblastoma Multiforme36	9.3	EGFR, SRC, PTEN, TP53, AKT3, AKT1
22	P2Y Receptor Signaling36	9.2	MAPK3, FGFR2, FGF7, FGF2, FOS, JUN
23	UPA-UPAR Pathway36	9.1	MAPK14, MAPK3, MAPK8, FOS, MMRN2, MMP9
24	EGF Pathway36	9.1	MAPK10, MAPK3, MAPK8, FOS, CDH1, JUN
25	14-3-3 Induced Intracellular Signaling36	9.1	EPHB3, EPHA7, EPHA1, RRAS2, PRKCA, FGF7
26	Development_EGFR signaling pathway41	9.1	MAPK1, MAPK3, MAPK8, FOS, MMP9, MMP2
27	Tuberculosis20	9.0	CASP9, CASP8, CASP3, IFNA1, MAPK9, MAPK1
28	Glioma20	8.9	PRKCA, CDKN2A, PIK3CA, CDK4, MDM2, EGFR
29	NFAT in Immune Response36	8.8	EGF, ERBB4, ERBB3, AKT3, AKT1, IGF1
30	ErbB signaling pathway20	8.8	AKT1, HRAS, MAPK9, MAPK1, MAPK10, MAPK3
31	Signal transduction PTEN pathway10	8.8	CASP9, CASP3, IGF1, IGF1R, MAPK1, MAPK3
32	Focal adhesion20	8.6	PRKCA, EGFR, EGF, SHC1, COL4A5, SRC
33	Colorectal Cancer Metastasis36	8.6	PTGS2, TP53, AKT1, CASP9, CASP3, CCND1
34	Endothelin-1 Signaling Pathway36	8.6	MAPK10, MAPK3, IL10, FGFR2, PIP, EPHA7
35	Prostate cancer20	8.5	PIK3CA, AKT1, HRAS, CASP9, IGF1, IGF1R
36	GSK3 Signaling36	8.4	EPHB3, EPHA7, EPHA1, RRAS2, CSNK1A1, MAPK8
37	Cellular Apoptosis Pathway36	8.4	MDM2, FGFR2, FGF7, FGF2, CDKN2A, CFLAR
38	TGF-Beta Pathway36	8.3	RRAS2, TIMP2, TIMP1, FGF2, FOS, CDH1
39	p53 Mediated Apoptosis36	8.3	TIMP2, TIMP1, EGFR, FGF2, BAX, BCL2
40	Mitochondrial Apoptosis36	8.3	IGF1, IGF1R, MDM2, FGFR2, FGF7, FGF2
41	Rho Family GTPases36	8.0	FOS, MMRN2, CDH1, CDH3, JUN, BAX
42	Estrogen Pathway36	7.9	AKT3, AKT1, HRAS, IGF1, IGF1R, CCND1
43	Melanoma20	7.8	EGFR, EGF, PTEN, TP53, AKT3, AKT1
44	p38 Signaling36	7.7	TIMP2, TIMP1, EGFR, EGF, SRC, TNFSF10
45	JAK-STAT Pathway36	7.6	CXCR4, MAPK1, MAPK3, IL10, FGFR2, FGF7
46	ERK Signaling36	7.6	EPHB3, EPHA7, EPHA1, RRAS2, PRKCA, TIMP2
47	ILK Signaling36	7.6	EPHB3, MAPK9, MAPK1, MAPK10, MAPK3, MAPK8
48	Pathways in cancer20	7.2	CDK2, JUN, MSH2, CEBPA, BAX, CHUK
49	Pancreatic Adenocarcinoma36	7.1	SRC, MMP9, MMP8, MMP3, MMP2, MMP19
50	Molecular Mechanisms of Cancer36	6.9	COL4A5, CYCS, PTEN, TNFSF10, TP53, ERBB4

Compounds related to skin cancer according to GeneDecks:

(show top 50)    (show all 450)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.0	CHUK, BAK1, P2RX7, P2RY2, P2RY4, CFLAR
2	benzo(a)pyrene32	10.5	BRCA1, XRCC1, XPA, XPC, CDK4, GSTM1
3	ascorbic acid32 18	11.3	PCNA, VDR, LIF, CHKA, CHUK, XRCC1
4	phenethyl isothiocyanate32	10.2	BCL2, BAX, JUN, GSTP1, MAPK8, MAPK1
5	vincristine32 34 9 9	13.2	FGF2, MAPK3, IFNA1, ODC1, POMC
6	n-(4-hydroxyphenyl)retinamide32	10.2	VIM, RARS, BCL2, CHUK, BAX, CFLAR
7	phosphatidylserine32 9 9	12.1	VIM, BCL2, BAK1, P2RX7, CDK2, GZMB
8	methylmethanesulfonate32	10.0	PCNA, BRCA1, BRCA2, XRCC1, XRCC6, JUN
9	parthenolide32	9.9	CHUK, MMP9, FASLG, MAPK8, MAPK14, MAPK10
10	nitric oxide32 9 18 9	12.8	LIF, BIRC5, LGALS3, P2RY1, P2RY2, ATF3
11	triptolide32	9.7	BCL2, BAX, JUN, MMP3, MAPK8, MAPK14
12	melphalan32 9 9	11.7	BIRC5, XRCC3, XRCC5, MMP2, GSTA1, GSTP1
13	c2ceramide32	9.7	CHUK, BAX, JUN, GSTA2, MAPK8, MAPK14
14	bleomycin32 9 9	11.6	BRCA1, BRCA2, XRCC1, XRCC5, XRCC6, CDKN3
15	calcium32 9 18 9	12.6	PI3, CNR1, BRCA1, LIF, BIRC5, LGALS3
16	superoxide32 18	10.5	PIK3CA, PI3, LIF, BIRC5, LGALS3, CHKA
17	depsipeptide32	9.4	LIF, BCL2, BAX, CFLAR, CDKN2A, CDH1
18	dihydrotestosterone32 9 18 9	12.4	PIP, VIM, VDR, CHKA, CDK2, CDK4
19	adpribose32	9.4	PIK3CA, PCNA, BRCA1, BRCA2, BIRC5, BAK1
20	15-deoxy-delta-12,14-prostaglandin j232	9.3	BIRC5, JUN, CDK2, FOS, FGF2, IL10
21	mifepristone32 42 9 9	12.2	PI3, LIF, BIRC5, BAX, JUN, CDK2
22	estradiol32 9 18 9	12.2	PIP, PCNA, VIM, BRCA1, BRCA2, LIF
23	okadaic acid32 42	10.2	PIK3CA, VIM, BCL2, CHUK, XRCC5, JUN
24	arachidonic acid32 9 18 9	12.1	PIK3CA, CNR1, VIM, LIF, P2RY1, P2RY2
25	pge232	8.9	LIF, P2RX7, CDH1, IVL, MMP3, MMP8
26	sulindac32 9 9	10.8	PCNA, BIRC5, BCL2, BAX, CDH1, MAPK3
27	calcitriol32 42 9 18 9	12.8	VDR, RARS, LIF, BAK1, JUN, CDK2
28	aspartate32	8.7	CNR1, PCNA, VIM, VDR, PAICS, CDKN2A
29	lipid32	8.7	PIK3CA, PI3, CNR1, CNR2, VIM, BRCA1
30	tgf beta132	8.6	LIF, CDK2, CDK4, CDH1, MMP14, MMP2
31	flavopiridol32 9 9	10.6	BIRC5, BCL2, BAK1, BAX, CFLAR, CDK2
32	vitamin d32	8.5	VIM, VDR, RARS, LGALS3, CHKA, MTHFR
33	thapsigargin32 42	9.3	CNR1, PCNA, BCL2, BAK1, CDKN3, IVL
34	cholesterol32 9 18 9	11.1	PIK3CA, CNR2, LIF, BIRC5, CHKA, MTHFR
35	paraffin32	7.8	PIP, PCNA, VIM, BRCA1, BRCA2, LIF
36	phosphotyrosine32	7.7	PIK3CA, BRCA1, YES1, FYN, CDK2, CDKN3
37	docetaxel32 34 9 9	10.7	BRCA1, BRCA2, VDR, BIRC5, BCL2, BAK1
38	thymidylate32	7.7	PCNA, VIM, BRCA1, VDR, BIRC5, BCL2
39	adriamycin32	7.5	VIM, BRCA1, BRCA2, VDR, BIRC5, BCL2
40	estrogen32	7.5	PIP, PCNA, BRCA1, BRCA2, VDR, BMI1
41	butyrate32	7.5	PCNA, VIM, VDR, BIRC5, BCL2, LGALS3
42	arsenite32 18	8.5	PIK3CA, PCNA, VDR, BIRC5, BCL2, CHUK
43	thymidine32 18	8.4	PIK3CA, CNR2, PCNA, BRCA1, BRCA2, VDR
44	indomethacin32 9 9	9.4	CNR1, PCNA, VIM, BIRC5, BAK1, CDK2
45	retinoic acid32 42 18	9.4	PIK3CA, PI3, BRCA1, BRCA2, VDR, RARS
46	gemcitabine32 34 9 9	10.1	PCNA, BRCA1, BIRC5, BCL2, BAX, MTHFR
47	wortmannin32 42	7.8	PIK3CA, PI3, VIM, LIG4, LIF, BIRC5
48	tamoxifen32 34 9 9	9.0	PIP, PIK3CA, PCNA, VIM, BRCA1, BRCA2
49	pd 98,05932	5.7	PIK3CA, LIF, BIRC5, BCL2, CHUK, BAX
50	genistein32 9 18 9	7.7	PIK3CA, PCNA, VIM, BRCA1, BRCA2, VDR

Cellular components related to skin cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	10.4	TNFSF10, HLA-B, ERBB3, F2RL1, F2R, HTR3A
2	caveola	GO:005901	9.8	ADRBK1, SRC, PTGS2, PTCH1, ERBB4, F2R
3	nucleoplasm	GO:005654	9.7	BRCA1, PCNA, POLR2L, TP53BP1, TP53, ERCC6
4	nucleolus	GO:005730	9.2	TERT, DROSHA, TP53, ERCC6, ERCC1, ERBB4
5	protein complex	GO:043234	8.6	PTGS2, DDB2, SSBP3, NR3C1, PRKCA, SOD1
6	cytosol	GO:005829	7.7	ODC1, SRC, CYCS, CYLD, DICER1, PTGES2
7	cytoplasm	GO:005737	7.6	AKT3, APRT, MDM2, FGFR2, FGF2, GSTP1
8	nucleus	GO:005634	7.4	ERBB4, ERCC2, ERCC3, ERCC5, ERCC8, ERCC1
9	plasma membrane	GO:005886	7.3	HLA-G, PTCH1, PTEN, PTGER1, PTGER4, PTGS1
10	extracellular space	GO:005615	6.8	FASLG, IGF1, F3, ALB, ERBB3, TNFSF10

Biological processes related to skin cancer according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to UV	GO:009411	11.2	XPA, CASP3, CASP9, ERCC5, ERCC3, ERCC8
2	nucleotide-excision repair, DNA damage removal	GO:000718	11.2	XPA, ERCC4, XPC, ERCC2, ERCC3, ERCC5
3	UV protection	GO:009650	11.1	GPX1, CAT, ERCC2, ERCC5, ERCC1, ERCC4
4	nucleotide-excision repair	GO:006289	11.0	DDB2, OGG1, POLR2L, ERCC4, ERCC1, ERCC8
5	aging	GO:007568	10.9	FAS, ERCC2, NR3C1, SHC1, ADRBK1, TIMP1
6	response to oxidative stress	GO:006979	10.9	ERCC3, PTGS2, ERCC6, ERCC1, TLR4, XPA
7	DNA repair	GO:006281	10.8	PCNA, BRCA1, BRCA2, LIG4, XRCC1, XRCC2
8	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	10.8	MAPK9, MAPK1, MAPK14, MAPK10, MAPK3, MAPK8
9	response to X-ray	GO:010165	10.7	XRCC2, LIG4, BRCA2, ERCC8, MSH2, ERCC6
10	TRIF-dependent toll-like receptor signaling pathway	GO:035666	10.7	CDK1, CHUK, TLR4, MAPK9, MAPK1, MAPK10
11	toll-like receptor 1 signaling pathway	GO:034130	10.7	FOS, MAPK3, TLR4, CHUK, JUN, MAPK9
12	toll-like receptor 2 signaling pathway	GO:034134	10.6	MAPK14, MAPK3, MAPK8, FOS, CDK1, JUN
13	toll-like receptor 3 signaling pathway	GO:034138	10.6	CHUK, TLR4, MAPK9, MAPK1, MAPK10, MAPK14
14	toll-like receptor signaling pathway	GO:002224	10.6	MAPK14, MAPK10, MAPK9, TLR4, MAPK3, MAPK8
15	response to gamma radiation	GO:010332	10.6	GPX1, ERCC6, TP53, BAX, BAK1, BCL2
16	innate immune response	GO:045087	10.6	LGALS3, TLR8, TLR7, TLR4, DMBT1, MAPK14
17	MyD88-dependent toll-like receptor signaling pathway	GO:002755	10.6	MAPK14, MAPK8, CDK1, MAPK3, FOS, CHUK
18	response to lipopolysaccharide	GO:032496	10.5	PTGER4, MMP9, CNR2, JUN, P2RX7, S100A7
19	release of cytochrome c from mitochondria	GO:001836	10.5	SOD2, CASP3, JUN, TP53, BCL2, BAK1
20	Toll signaling pathway	GO:008063	10.5	TLR4, MAPK1, MAPK9, MAPK10, MAPK14, MAPK3
21	toll-like receptor 4 signaling pathway	GO:034142	10.5	CHUK, JUN, CDK1, FOS, MAPK8, MAPK3
22	glutathione metabolic process	GO:006749	10.5	SOD1, GSTA3, GSTA4, GSTA2, GSTP1, GSTM3
23	MyD88-independent toll-like receptor signaling pathway	GO:002756	10.4	MAPK9, JUN, MAPK1, MAPK10, MAPK14, MAPK3
24	angiogenesis	GO:001525	10.4	EPHB3, EPHA1, PRKCA, EGF, SHC1, JUN
25	induction of apoptosis by intracellular signals	GO:008629	10.3	BAK1, CASP9, BCL2, CASP3, BAX, GZMB
26	cellular response to mechanical stimulus	GO:071260	10.2	TLR7, TLR4, PTGER4, CASP8, MAPK3, MAPK8
27	transcription-coupled nucleotide-excision repair	GO:006283	10.2	POLR2L, ERCC6, ERCC4, ERCC1, ERCC8, ERCC5
28	response to toxin	GO:009636	10.2	TLR4, SHC1, GPX1, FAS, CDH1, ERCC6
29	activation of pro-apoptotic gene products	GO:008633	10.2	AKT1, CASP8, MAPK8, BAK1, FAS, FASLG
30	response to DNA damage stimulus	GO:006974	10.2	MAPK3, FANCL, MICA, BCL2, BAX, CASP9
31	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.1	F2R, CCR7, F2RL1, ERBB4, MAPK3, FGFR2
32	extracellular matrix disassembly	GO:022617	10.1	MMP14, MMP10, TIMP2, TIMP1, MMP9, MMP8
33	negative regulation of cell proliferation	GO:008285	10.0	SOD2, PTGS2, SMAD2, CYP27B1, SMARCA2, PTEN
34	negative regulation of neuron apoptotic process	GO:043524	9.9	SOD1, ERBB3, HRAS, F2R, JUN, MSH2
35	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.9	VDR, HRAS, AKT1, CEBPA, ERCC2, ERCC3
36	virus-host interaction	GO:019048	9.8	HLA-B, FYN, MICB, MICA, CXCR4, STAT3
37	nerve growth factor receptor signaling pathway	GO:048011	9.8	PIK3CA, HRAS, PRKCA, AKT1, PTEN, CHUK
38	response to ethanol	GO:045471	9.6	TLR4, CDK1, CASP8, STAT3, PRKCA, SOD1
39	Ras protein signal transduction	GO:007265	9.4	MAPK3, FGF2, CDK1, CDKN2A, CDK2, MAPK14
40	fibroblast growth factor receptor signaling pathway	GO:008543	9.4	MDM2, FGFR2, FGF7, FOXO4, CDK1, CHUK
41	response to drug	GO:042493	9.2	ERBB3, PTGS2, IL10, MMP9, CDH1, CDK1
42	negative regulation of apoptotic process	GO:043066	9.1	ERCC5, EGFR, ERBB4, AKT1, CD44, TP53
43	apoptotic process	GO:006915	9.0	FGF2, GZMB, CDH1, MSH2, CFLAR, BAX
44	activation of MAPK activity	GO:000187	9.0	CDK1, FGF2, MAPK3, MAPK14, MAPK10, MAPK1
45	epidermal growth factor receptor signaling pathway	GO:007173	8.9	EGF, SRC, FOXO4, CHUK, PRKCA, MDM2
46	anti-apoptosis	GO:006916	8.9	SOD1, FAS, IL10, GSTP1, CDK1, CFLAR
47	positive regulation of transcription, DNA-dependent	GO:045893	8.7	IL10, SMAD2, SMARCA2, CDKN2A, CDK2, JUN
48	positive regulation of cell proliferation	GO:008284	8.5	IGF1R, FASLG, IGF1, MDM2, FGFR2, FGF2
49	platelet activation	GO:030168	8.3	PIK3CA, P2RY1, FYN, MAPK3, MAPK14, MAPK1
50	blood coagulation	GO:007596	7.9	YES1, EGF, TIMP1, PRKCA, SOD1, ALB

Molecular functions related to skin cancer according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	damaged DNA binding	GO:003684	11.0	POLH, OGG1, DDB2, ERCC4, ERCC1, ERCC3
2	glutathione transferase activity	GO:004364	10.6	GSTT1, GSTP1, GSTM3, GSTM1, GSTA4, GSTA3
3	DNA-dependent ATPase activity	GO:008094	10.6	XRCC2, XRCC3, ERCC2, ERCC3, ERCC8, ERCC6
4	protein C-terminus binding	GO:008022	10.1	ERCC2, ERCC3, ERCC1, ERCC4, ERCC6, HRAS
5	protein kinase activity	GO:004672	10.0	PLK1, PKMYT1, PRKCA, CSNK1A1, POLR2L, ADRBK1
6	protein homodimerization activity	GO:042803	9.8	HLA-G, ERCC5, ERBB4, ERBB3, HPRT1, TERT
7	enzyme binding	GO:019899	9.6	MDM2, CCND1, CAT, AKT1, TP53, PTEN
8	ATP binding	GO:005524	9.4	ERCC6, ERCC3, ERCC2, ERBB4, ERBB3, AKT3
9	protein tyrosine kinase activity	GO:004713	8.9	EPHA7, EGFR, SHC1, SRC, ERBB4, ERBB3
10	identical protein binding	GO:042802	8.6	MDM2, FAS, IGF1R, CASP8, AKT1, TP53
11	protein binding	GO:005515	4.4	F2RL1, ERCC6, TP53, TP53BP1, TNFSF10, DROSHA