MCID: SKN014
MIFTS: 58

Skin Cancer malady

Summaries for Skin Cancer

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Skin cancer is the most common form of cancer in the united states. the two most common types are basal cell cancer and squamous cell cancer. they usually form on the head, face, neck, hands, and arms. another type of skin cancer, melanoma, is more dangerous but less common. anyone can get skin cancer, but it is more common in people who spend a lot of time in the sun or have been sunburned have light-colored skin, hair and eyes have a family member with skin cancer are over age 50 you should have your doctor check any suspicious skin markings and any changes in the way your skin looks. treatment is more likely to work well when cancer is found early. if not treated, some types of skin cancer cells can spread to other tissues and organs. treatments include surgery, radiation therapy, chemotherapy, photodynamic therapy (pdt), and biologic therapy. pdt uses a drug and a type of laser light to kill cancer cells. biologic therapy boosts your body's own ability to fight cancer. nih: national cancer institute

MalaCards: Skin Cancer, also known as skin carcinoma, is related to squamous cell carcinoma and xeroderma pigmentosum. An important gene associated with Skin Cancer is MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)), and among its related pathways are Nucleotide Excision Repair and Chks in Checkpoint Regulation. The compounds cisplatin and oligonucleotide have been mentioned in the context of this disorder. Affiliated tissues include the skin, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Disease Ontology:8 An organ system cancer located in the skin that is the uncontrolled growth of abnormal skin cells.

CDC:3 Skin cancer is the most common form of cancer in the United States. In the United States in 2010,* 61,061 people were diagnosed with melanomas of the skin, and 9,154 people died from it.† CDC leads national efforts to reduce skin cancer through education. When in the sun, seek shade, cover up, get a hat, wear sunglasses, and use sunscreen.

Wikipedia:64 Skin cancers (skin neoplasms) are named after the type of skin cell from which they arise. Basal cell... more...

Aliases & Classifications for Skin Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

skin cancer 8 43 10 45 34
skin carcinoma 8 45 61
malignant neoplasm of skin 8 61
malignant neoplasm of skin, unspecified 8
melanoma and non-melanoma skin cancer 8
malignant neoplasm of skin nos 8
non-melanoma skin cancer 8
nonmelanoma skin cancer 45
carcinoma of skin 8
ca - skin cancer 8


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Disease Ontology8 DOID:4159, DOID:3451
NCIt40 C2920, C4914
MeSH35 D012878

Related Diseases for Skin Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Skin Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.5ODC1, MMP10, MMP12, MMP19
2xeroderma pigmentosum30.5PTCH1, DDB2, XPC, XPA, XRCC3, XRCC1
3basal cell carcinoma30.4PTCH1
4oculocutaneous albinism30.3TYRP1, MC1R
5albinism30.2TYRP1, MC1R
6colorectal cancer30.0ODC1, XRCC1, XRCC3, XPC, CYP27B1, MMP12
7cockayne syndrome30.0XPA, XPC, DDB2, ERCC5, ERCC2
8oral cancer30.0TP53, TERC
9nevoid basal cell carcinoma syndrome30.0PTCH1
10vitiligo30.0TYRP1
11brain cancer29.8MAPK9, TYRP1, TERC, PTCH1, TP53
12fanconi's anemia29.8ERCC2, PTCH1, TERC
13thyroid cancer29.8TP53, PTCH1
14ulcerative colitis29.8TP53
15epidermodysplasia verruciformis10.4
16actinic keratosis10.4
17radiation induced cancer10.3
18skin squamous cell carcinoma10.3
19n syndrome10.2
20verrucous carcinoma10.2
21merkel cell carcinoma10.2
22skin pilomatrix carcinoma10.1
23palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal10.1
24xeroderma pigmentosum, group c10.1
25xeroderma pigmentosum, group f10.1
26sarcomatoid squamous cell skin carcinoma10.1
27skin carcinoma in situ10.1
28plantar verrucous skin carcinoma10.1
29alzheimer's disease10.0
30porokeratosis10.0
31hermansky-pudlak syndrome10.0
32oculocutaneous albinism type 210.0
33mutagen sensitivity10.0
34skin cancer, non melanoma, childhood10.0
35cutaneous malignant melanoma10.0
36xeroderma pigmentosum, group g10.0
37basaloid squamous cell skin carcinoma10.0
38neuroendocrine carcinoma10.0
39clear cell squamous cell skin carcinoma10.0
40acantholytic squamous cell skin carcinoma10.0
41melanoma10.0ODC1, XRCC1, XRCC3, TP53, ASIP, ERCC2
42adenocarcinoma10.0XPC, XPA, XRCC3, XRCC1, ODC1, CHKA
43non-small cell lung carcinoma10.0ODC1, XRCC1, XRCC3, XPC, CHKA, MMP10
44breast cancer10.0ODC1, CHKA, MAPK9, CYP27B1, TERC, PTCH1
45hepatocellular carcinoma10.0XPC, CHKA, CYP27B1, MMP12, TERC, PTCH1
46adenoma10.0ODC1, XRCC1, XRCC3, CHKA, TERC, ERCC2
47leukemia10.0ODC1, XRCC1, MAPK9, CYP27B1, TERC, ERCC2
48colon cancer10.0ODC1, XRCC1, CHKA, CYP27B1, TERC, PTCH1
49lung benign neoplasm10.0XRCC1, XPC, MMP10, TERC, ERCC2, TP53
50ovarian cancer10.0XPA, CHKA, CYP27B1, TERC, ERCC2, TP53

Graphical network of the top 20 diseases related to Skin Cancer:



Diseases related to skin cancer

Clinical Features for Skin Cancer

Drugs & Therapeutics for Skin Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Skin Cancer

Drug clinical trials:

Search ClinicalTrials for Skin Cancer

Search NIH Clinical Center for Skin Cancer

Search CenterWatch for Skin Cancer

Genetic Tests for Skin Cancer

Anatomical Context for Skin Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Skin Cancer:

14
The skin

Animal Models for Skin Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Skin Cancer:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537812.0TYRP1, MAPK9, DDB2, XPC, XPA, XRCC1
2MP:000537611.9XRCC1, XPA, XPC, CHKA, MAPK9, TYRP1
3MP:001076811.8CHKA, DDB2, XPC, XPA, XRCC1, ODC1
4MP:000538411.8ODC1, XRCC1, XPA, XPC, DDB2, MAPK9
5MP:000538611.6XRCC1, XPA, XPC, MAPK9, TYRP1, MC1R
6MP:000538711.6MMP10, CYP27B1, MAPK9, XPA, MMP12, TERC
7MP:001077111.5XPC, DDB2, TYRP1, CYP27B1, MC1R, MMP12
8MP:000539711.4XPA, MAPK9, CYP27B1, MMP12, TERC, PTCH1
9MP:000200611.3ASIP, MAPK9, TYRP1, MC1R, MMP19, TERC
10MP:000538211.1XPA, MAPK9, TYRP1, MC1R, PTCH1, ASIP
11MP:000538911.1MAPK9, TYRP1, CYP27B1, TERC, PTCH1, TP53
12MP:000539111.0TYRP1, PTCH1, ASIP
13MP:000363111.0TYRP1, MMP12, PTCH1, ASIP
14MP:000118610.9XPA, ASIP
15MP:000539010.9XPA, TYRP1, CYP27B1, PTCH1, ASIP
16MP:000537110.9XPA, ASIP
17MP:000538010.8ASIP, PTCH1, MAPK9, ODC1
18MP:000537910.8CYP27B1, TERC, ERCC2, ASIP, TP53
19MP:000537510.6ASIP, MMP19
20MP:000537010.6XPA, CHKA, MAPK9, ERCC5, ASIP, TP53

Publications for Skin Cancer

Sources:
51PubMed
See all sources

Articles related to Skin Cancer:

(show top 50)    (show all 915)
idTitleAuthorsYear
1
Cytochromes p450 and skin cancer: role of local endocrine pathways. (23869782)
2014
2
Imiquimod in the Treatment of Breast Cancer Skin Metastasis. (24419128)
2014
3
The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D). (24252196)
2013
4
Photodynamic therapeutic effect of indocyanine green entrapped in polymeric nanoparticles and their anti-EGFR-conjugate in skin cancer in CD1 mice. (24284098)
2013
5
Clinical characteristics and awareness of skin cancer in Hispanic patients. (24050296)
2013
6
Quality of life in non-melanoma skin cancer--the skin cancer quality of life (SCQoL) questionnaire. (24237851)
2013
7
Skin cancer education among massage therapists: a survey at the 2010 meeting of the American Massage Therapy Association. (22915212)
2013
8
The Risk of Skin Cancer in Psoriasis Patients Treated with UVB Therapy. (24322826)
2013
9
Melanoma in buckinghamshire: data from the inception of the skin cancer multidisciplinary team. (24163771)
2013
10
The incidence of skin cancer in dermatology. (24073653)
2013
11
Abstracts of the 8th World Congress of Melanoma, the 9th Congress of the European Association of Dermatology (EADO), the 7th Interdisciplinary Melanoma/Skin Cancer Meeting, and the 3rd European Post-Chicago Melanoma Meeting. July 17-20, 2013. Hamburg, Germany. (23865941)
2013
12
The addition of the surgical robot to skin cancer management. (23317733)
2013
13
Analysis of skin cancer treatment and costs in the United States Medicare population, 1996-2008. (23199014)
2013
14
Plasma 25-hydroxyvitamin D and risk of non-melanoma and melanoma skin cancer: a prospective cohort study. (23190899)
2013
15
Risk of attrition in a longitudinal study of skin cancer: logistic and survival models can give different results. (23810028)
2013
16
Nonmelanoma skin cancer visits and procedure patterns in a nationally representative sample: national ambulatory medical care survey 1995-2007. (23331766)
2013
17
Incidence of primary skin cancer after organ transplantation: An 18-year single-center experience in Korea. (24342756)
2013
18
Green tea polyphenol, (-)-epigallocatechin-3-gallate, induces toxicity in human skin cancer cells by targeting I^-catenin signaling. (24096034)
2013
19
Non-melanoma skin cancer: carcinogenesis and chemoprevention. (23478234)
2013
20
A single center retrospective study on 959 excisions of non-melanoma skin cancer in 2011. (23751973)
2013
21
Knowledge, behavior and attitudes related to skin cancer prevention among final year medical students. (23131436)
2012
22
UV radiation and skin cancer: the science behind age restrictions for tanning beds. (22854243)
2012
23
Protective actions of vitamin D in UVB induced skin cancer. (22990497)
2012
24
Indoor tanning and non-melanoma skin cancer: systematic review and meta-analysis. (23033409)
2012
25
Validity of patient skin cancer report among organ transplant recipients. (22428900)
2012
26
A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity. (23060038)
2012
27
Pleomorphic malignant histiocytoma: a rare skin cancer in a patient on azathioprine for ulcerative colitis. (22761209)
2012
28
Visual images for skin cancer prevention: a systematic review of qualitative studies. (22481615)
2012
29
Diffuse Muscular Pain, Skin Tightening, and Nodular Regenerative Hyperplasia Revealing Paraneoplastic Amyopathic Dermatomyositis due to Testicular Cancer. (23316407)
2012
30
Dermatology undergraduate skin cancer training: a disconnect between recommendations, clinical exposure and competence. (22569037)
2012
31
Nuclear translocation of ATBF1 is a potential prognostic marker for skin cancer. (23317484)
2012
32
Mild clinical phenotype of Kindler syndrome associated with late diagnosis and skin cancer. (20938162)
2010
33
PTH-independent hypercalcaemia and non-melanoma skin cancer. (19778357)
2010
34
Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer. (18191509)
2008
35
The role of topical cyclo-oxygenase-2 inhibitors in skin cancer: treatment and prevention. (17645375)
2007
36
Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells. (17390728)
2007
37
Evaluation of anemia, neutropenia and skin toxicities in standard or dose-dense doxorubicin/cyclophosphamide (AC)-paclitaxel or docetaxel adjuvant chemotherapy in breast cancer. (15668278)
2005
38
Expression of two androgen-induced proteins (pepsinogen C and apolipoprotein d) in epithelial skin cancers of the eyelids. (15004501)
2004
39
Effects of cathepsin D inhibitor from Vicia sativa L. seed hulls on human skin fibroblasts and breast cancer cells (in vitro studies). (15638434)
2004
40
Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer. (12771951)
2003
41
The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction. (11782372)
2002
42
Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes. (11710928)
2001
43
Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine residues in solar UV mutagenesis. (11152598)
2001
44
UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. (11684448)
2001
45
Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expression. (10797288)
2000
46
Human papillomavirus DNA in non-melanoma skin cancers of a renal transplant recipient: detection of a new sequence related to epidermodysplasia verruciformis associated types. (8980287)
1997
47
Induction of cancer, actinic keratosis, and specific p53 mutations by UVB light in human skin maintained in severe combined immunodeficient mice. (9187098)
1997
48
The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer. (8286219)
1993
49
Association of nonmelanoma skin cancer and actinic keratosis with cumulative solar ultraviolet exposure in Maryland watermen. (2340474)
1990
50
Actinic keratosis: preventable and treatable like other precancerous and cancerous skin lesions. (2675146)
1989

Genetic Variations for Skin Cancer

Expression for genes affiliated with Skin Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Skin Cancer

Search GEO for disease gene expression data for Skin Cancer.

Pathways for genes affiliated with Skin Cancer

Sources:
54Reactome, 52QIAGEN, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Pathways related to Skin Cancer according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9ERCC2, ERCC5, DDB2, XPC, XPA, XRCC1
2
Hide members
10.9XRCC1, XPA, XPC, MAPK9, ERCC5, ERCC2
3
Hide members
10.9TYRP1, MC1R, PTCH1, ASIP, TP53
4
Hide members
10.9TP53, MMP19, MMP12, MMP10, MAPK9
5
Transcription P53 signaling pathway
Hide members
10.9TP53, ERCC2, MAPK9, XPC, XPA
6
Hide members
10.8ERCC2, DDB2, XPC, XRCC1
7
Hide members
10.7XPC, DDB2, ERCC5
8
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.7TP53, DDB2, XPC
9
Hide members
10.7MMP19, MMP12, MMP10
10
Cell adhesion ECM remodeling
Hide members
10.7MMP10, MMP12, MMP19
11
Hide members
10.7MMP10, MMP12, MMP19
1210.7XRCC3, ERCC2, TP53
1310.7TP53, ERCC2, XRCC3
14
Hide members
10.6ERCC2, TP53
1510.6MAPK9, PTCH1

Compounds for genes affiliated with Skin Cancer

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB
See all sources

Compounds related to Skin Cancer according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1cisplatin45 50 60 1114.7TP53, XRCC1, XRCC3, XPA, XPC, DDB2
2oligonucleotide4511.7XRCC1, XPA, XPC, TYRP1, CYP27B1, MMP10
3tyrosine4511.6ODC1, XRCC1, XPC, CHKA, MAPK9, TYRP1
4n acetylcysteine4511.4ODC1, XRCC3, CHKA, MAPK9, MMP12, TP53
5paraffin4511.3ODC1, CHKA, CYP27B1, TERC, PTCH1, TP53
6oxaliplatin45 50 1113.3ODC1, XRCC1, XPA, ERCC2, TP53
7folate4511.3ODC1, XRCC1, XRCC3, MC1R, ERCC2
8doxorubicin45 50 1113.2TP53, TERC, MAPK9, CHKA, ODC1
9forskolin45 50 1113.2MAPK9, TYRP1, CYP27B1, MC1R, ASIP
10h2o24511.2ODC1, MAPK9, TYRP1, MC1R
11serine4511.2CHKA, TYRP1, MC1R, MMP10, MMP12
12benzo(a)pyrene4511.2TP53, XPC, XPA, XRCC1
13alpha tocopherol4511.2ODC1, XRCC1, CHKA, MMP19
14thymidylate4511.2ODC1, XRCC1, ERCC2, TP53
15camptothecin45 60 1113.2XRCC1, XRCC3, MAPK9, TP53
16eumelanin4511.1ASIP, MC1R, TYRP1
17uk 3833676011.1MMP10, MMP12, MMP19
18gi 254023x6011.1MMP10, MMP12, MMP19
19gm 60016011.1MMP10, MMP12, MMP19
205fluorouracil4511.1XRCC1, TERC, ERCC2, TP53
21fluorouracil50 1112.1TP53, ERCC2, XRCC1
22marimastat45 60 1113.1MMP10, MMP12, MMP19
23calcium45 50 11 2414.1MMP19, MMP12, MMP10, MC1R, CYP27B1, TYRP1
24agar4511.1ODC1, MAPK9, TYRP1, TERC
25cyclic amp45 2412.1CHKA, TYRP1, CYP27B1, MC1R, ASIP
26batimastat45 60 1113.1MMP19, MMP12, MMP10
27melphalan45 1112.0TP53, ERCC2, XRCC3
28n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid45 1112.0MMP10, MMP12
29phaeomelanin4511.0MC1R, ASIP
30betacarotene4511.0ODC1, XRCC1, CHKA
31sarcnu4511.0TP53, ERCC2
32cpds4511.0XPA, DDB2
33denspm4510.9ODC1, TP53
34cadmium45 2411.9MAPK9, XPA, XRCC1
35matrigel4510.9MMP10, ODC1
36dopachrome4510.9TYRP1, MC1R
37ecteinascidin 7434510.9ERCC5, ERCC2
38irinotecan45 50 1112.8XRCC1, ERCC2, TP53
39platinum compounds5010.8ERCC2, XRCC1
402-acetylaminofluorene4510.8XPC, XPA
41adpribose4510.8TP53, TERC, XRCC1
42alpha msh4510.6MC1R, ASIP
43mitomycin c4510.6TP53, XPA, XRCC3
44vincristine45 50 1112.4ODC1, ERCC2, TP53

GO Terms for genes affiliated with Skin Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Skin Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:00565410.8TP53, XRCC1, XPA, XPC, DDB2, MAPK9
2holo TFIIH complexGO:00567510.6ERCC2, ERCC5

Biological processes related to Skin Cancer according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1DNA repairGO:00628111.2XRCC1, XRCC3, XPA, XPC, DDB2, ERCC5
2nucleotide-excision repairGO:00628911.2XPA, XPC, DDB2, ERCC5, ERCC2, TP53
3nucleotide-excision repair, DNA damage removalGO:00071811.1ERCC2, ERCC5, DDB2, XPC, XPA
4melanin biosynthetic processGO:04243810.9ASIP, MC1R, TYRP1
5UV protectionGO:00965010.9MC1R, ERCC5, ERCC2
6response to UVGO:00941110.9ERCC5, DDB2, XPA
7multicellular organism growthGO:03526410.8TP53, ERCC2, XPA
8regulation of mitotic cell cycle phase transitionGO:190199010.7XPC, ERCC2
9collagen catabolic processGO:03057410.7MMP10, MMP12, MMP19
10melanosome organizationGO:03243810.6ASIP, TYRP1
11extracellular matrix disassemblyGO:02261710.6MMP19, MMP12, MMP10
12extracellular matrix organizationGO:03019810.5MMP10, MMP12, MMP19, ERCC2

Molecular functions related to Skin Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.4XRCC3, XPA, XPC, DDB2, MAPK9, TYRP1
2damaged DNA bindingGO:00368410.9TP53, DDB2, XPC, XPA, XRCC1
3bubble DNA bindingGO:00040510.6XPC, ERCC5
4protein N-terminus bindingGO:04748510.6TP53, ERCC2, ERCC5
5metalloendopeptidase activityGO:00422210.4MMP10, MMP12, MMP19

Products for genes affiliated with Skin Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Skin Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet