MCID: SKN027
MIFTS: 42

Skin Conditions malady

Skin diseases category
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Summaries for Skin Conditions

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MedlinePlus:33 Your skin is your body's largest organ. it covers and protects your body. your skin holds body fluids in, preventing dehydration keeps harmful microbes out, preventing infections helps you feel things like heat, cold, and pain keeps your body temperature even makes vitamin d when the sun shines on it anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling, burning, and itching. allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. many skin problems, such as acne, also affect your appearance. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Skin Conditions is related to psoriatic arthritis and skin disease. An important gene associated with Skin Conditions is IL1A (interleukin 1, alpha), and among its related pathways are Downstream signaling in naive CD8+ T cells and Prion diseases. The drugs prednisolone and prednisone and the compounds rantes and tocilizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and pancreas.

Wikipedia:65 Many conditions affect the human integumentary system?the organ system covering the entire surface of... more...

Aliases & Classifications for Skin Conditions

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Skin Conditions, Aliases & Descriptions:

Name: Skin Conditions 30 33 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Skin Conditions

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Graphical network of the top 20 diseases related to Skin Conditions:



Diseases related to skin conditions

Symptoms for Skin Conditions

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Drugs & Therapeutics for Skin Conditions

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Genetic Tests for Skin Conditions

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Anatomical Context for Skin Conditions

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MalaCards organs/tissues related to Skin Conditions:

32
Skin, T cells, Pancreas

Animal Models for Skin Conditions or affiliated genes

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Publications for Skin Conditions

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Articles related to Skin Conditions:

(show all 42)
idTitleAuthorsYear
1
Association between skin conditions and depressive disorders in community-dwelling older adults. (25008442)
2014
2
What should primary care providers know about pediatric skin conditions? A modified Delphi technique for curriculum development. (25087213)
2014
3
Retraction. Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. (24971365)
2014
4
Skin conditions in primary care: an analysis of referral demand. (24657024)
2014
5
Increasing use of non-traditional vehicles for psoriasis and other inflammatory skin conditions. (25244174)
2014
6
EQ-5D in skin conditions: an assessment of validity and responsiveness. (25358263)
2014
7
Infective skin conditions in an adult sea-going population. (24881427)
2014
8
Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions. (24909886)
2014
9
Follicular mucinosis associated with nonlymphoid skin conditions. (25072678)
2014
10
Topical photodynamic therapy for non-malignant skin conditions: experience from a university teaching hospital. (24517855)
2014
11
Skin conditions in community-living older adults: prevalence and characteristics of medical care service use. (24800707)
2014
12
Quality of life in pediatric patients before and after cosmetic camouflage of visible skin conditions. (25218434)
2014
13
Idiopathic hypereosinophilic syndrome with multiple organ infarction: improvement of the skin condition masking the course of disease. (24667633)
2014
14
Therapeutic use of stories for children with atopic eczema and other chronic skin conditions. (24069961)
2013
15
Follicular Mucinosis Associated With Nonlymphoid Skin Conditions. (24061405)
2013
16
Daily intake of Jeju groundwater improves the skin condition of the model mouse for human atopic dermatitis. (23294459)
2013
17
Pyoderma gangrenosum - a frequently misdiagnosed skin condition. (24033196)
2013
18
Sparassis crispa (Hanabiratake) ameliorates skin conditions in rats and humans. (24018675)
2013
19
Aberrant distribution patterns of corneodesmosomal components of tape-stripped corneocytes in atopic dermatitis and related skin conditions (ichthyosis vulgaris, Netherton syndrome and peeling skin syndrome type B). (23810772)
2013
20
The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions. (24166134)
2013
21
Altered expression of antimicrobial peptide genes in the skin of dogs with atopic dermatitis and other inflammatory skin conditions. (23701024)
2013
22
Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. (24078929)
2013
23
Will epigenetics change our approach to treating skin conditions? (24517043)
2013
24
Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear. (22726258)
2012
25
Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions. (23171461)
2012
26
Use of frozen poloxamer as a base for Itchy skin conditions, including irritant contact dermatitis. (21781082)
2011
27
Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (21454693)
2011
28
Identifying when therapy for one skin disease is likely to exacerbate another skin condition. (21768483)
2011
29
New horny layer marker proteins for evaluating skin condition in atopic dermatitis. (19339807)
2009
30
Lobomycosis-like disease and other skin conditions in Indo-Pacific bottlenose dolphins Tursiops aduncus from the Indian Ocean. (19476285)
2009
31
Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas. (18414166)
2008
32
Urticaria and urticaria related skin condition/disease in children. (18700329)
2008
33
An overview of molluscum contagiosum: a viral skin condition. (18616033)
2008
34
Analysis of IFN-kappa expression in pathologic skin conditions: downregulation in psoriasis and atopic dermatitis. (16542135)
2006
35
Ivermectin improves the skin condition and self-esteem of females with onchocerciasis: a report of two cases. (15257804)
2004
36
Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions. (15377337)
2004
37
Absent or low expression of T-cell receptor zeta-chain in T cells infiltrating human pathological skin conditions. (12420108)
2002
38
A noninvasive method to assess skin irritation and compromised skin conditions using simple tape adsorption of molecular markers of inflammation. (11737818)
2001
39
The prevalence of common skin conditions in Australian school students: 4 Tinea pedis. (10354029)
1999
40
Interleukin-1 alpha- and beta-, interleukin-6- and tumour necrosis factor-alpha-like immunoreactivities in chronic granulomatous skin conditions. (7701874)
1994
41
Neurodermatitis: a skin condition that affects surgical wound healing. (893969)
1977
42
SOME SKIN CONDITIONS: ECZEMA AND IMPETIGO CONTAGIOSA. (14156185)
1964

Variations for Skin Conditions

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Expression for genes affiliated with Skin Conditions

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Expression patterns in normal tissues for genes affiliated with Skin Conditions

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Pathways for genes affiliated with Skin Conditions

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Pathways related to Skin Conditions according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Ras signaling in the CD4+ TCR pathway37
9.9CD247, TNF
29.8IL1A, IL6
39.8IL6, TNF
49.8IL6, TNF
59.8IL6, TNF
69.8TNF, IL6
79.8TNF, IL6
8
Show member pathways
IL27-mediated signaling events37
9.8TNF, IL6
9
Show member pathways
9.5IL1A, IL6, TNF
109.5IL1A, IL6, TNF
11
Show member pathways
9.5TNF, IL6, IL1A
12
Show member pathways
9.5IL1A, IL6, TNF
139.5IL1A, IL6, TNF
14
Show member pathways
9.5TNF, IL6, IL1A
15
Show member pathways
9.5IL1A, IL6, TNF
169.5TNF, IL6, IL1A
179.5IL1A, IL6, TNF
189.5IL1A, IL6, TNF
199.5IL1A, IL6, TNF
209.5TNF, IL6, IL1A
21
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5TNF, IL6, IL1A
229.5TNF, IL6, IL1A
239.5IL1A, IL6, TNF
24
Show member pathways
Immune response MIF in innate immunity response60
9.5IL1A, IL6, TNF
259.5TNF, IL6, IL1A
26
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.5TNF, IL6, CD247
27
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.5TNF, IL6, CD247
28
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.2TNF, IL6, IL1A, CD247
29
Show member pathways
9.2TNF, IFNK, IL6, IL1A
30
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.2TNF, IFNK, IL6, IL1A
31
Show member pathways
9.0AIM2, TNF, IL6

Compounds for genes affiliated with Skin Conditions

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Compounds related to Skin Conditions according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1rantes4410.5IL1A
2tocilizumab44 1111.2TNF, IL6
3gold sodium thiomalate4410.2TNF, IL1A
4abatacept44 1111.2IL6, TNF
5cdp5714410.2TNF, IL6
6anakinra44 1111.2IL6, TNF
7taurine chloramine4410.2IL6, TNF
8vesnarinone4410.2IL6, TNF
9gabexate mesilate4410.2TNF, IL6
10ulinastatin4410.2TNF, IL6
11mip 1alpha4410.2IL6, TNF
12il-124410.1IL6, TNF
13adalimumab44 50 1112.1IL6, TNF
14tpck4410.1TNF, IL6
15leflunomide44 50 1112.1IL6, TNF
16okt34410.1TNF, IL6
17triptolide4410.0IL6, TNF
18ciglitazone44 2811.0IL6, TNF
19sulfasalazine28 44 50 1113.0TNF, IL1A
20parthenolide44 211.0TNF, IL6
21lipoteichoic acid4410.0IL6, TNF
22tenidap44 2811.0IL1A, IL6, TNF
23imiquimod44 61 28 1113.0IL1A, IL6, TNF
24polymyxin b4410.0IL6, IL1A, TNF
25groalpha4410.0TNF, IL6, IL1A
26gm-csf44 2811.0IL1A, IL6, TNF
27polyinosinic-polycytidylic acid4410.0TNF, IL1A, IL6
28il 104410.0IL1A, IL6, TNF
29ivig4410.0IL1A, IL6, TNF
30ccl344 2811.0IL1A, IL6, TNF
31pentoxifylline44 1111.0TNF, IL6, IL1A
32neopterin4410.0TNF, IL6, IL1A
33pdtc449.9TNF, IL6, IL1A
34ns 39844 6110.9TNF, IL1A
35thalidomide44 50 61 1112.9TNF, IL6, IL1A
36leukotriene b444 61 2411.9IL1A, TNF, IL6
37hydrocortisone44 2 61 1112.9IL6, TNF, IL1A
388-isoprostane449.9TNF, IL6
39herbimycin a44 6110.9IL1A, IL6, TNF
40simvastatin44 50 61 28 24 1114.9TNF, IL6, IL1A
41endotoxin449.9IL1A, IL6, TNF
42curcumin449.9IL6, TNF, IL1A
43prostaglandin449.9IL6, IL1A, TNF
44calcitriol44 61 24 1112.9TNF, IL1A, IL6
45methylcellulose449.8IL6, IL1A
46indomethacin44 28 61 1112.8IL6, TNF, IL1A
472,5-oligoadenylate449.8IL6, TNF
48sb 20358044 6110.8IL1A, IL6, TNF
49etanercept44 50 1111.7IL6, TNF
50poly(i-c)449.5TNF, IL6

GO Terms for genes affiliated with Skin Conditions

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Cellular components related to Skin Conditions according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7IL1A, IL6, IFNK, TNF, IGFL1
2extracellular regionGO:0055767.2IL1A, IGFL3, IGFL2, TNF, DCD, IFNK

Biological processes related to Skin Conditions according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:05071510.1TNF, IL1A
2negative regulation of lipid storageGO:01088810.1TNF, IL6
3epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1IL6, TNF
4positive regulation of chemokine productionGO:03272210.1IL6, TNF
5positive regulation of mitosisGO:04584010.1IL1A, TNF
6negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.0IL1A, TNF
7positive regulation of nitric oxide biosynthetic processGO:04542910.0IL6, TNF
8defense response to Gram-positive bacteriumGO:0508309.9TNF, IL6
9negative regulation of fat cell differentiationGO:0455999.9IL6, TNF
10positive regulation of interleukin-6 productionGO:0327559.8IL6, TNF
11response to mechanical stimulusGO:0096129.8TNF, IL6
12humoral immune responseGO:0069599.8IFNK, TNF, IL6
13cytokine-mediated signaling pathwayGO:0192219.7IL6, IFNK, IL1A
14positive regulation of smooth muscle cell proliferationGO:0486619.7IL6, TNF
15tumor necrosis factor-mediated signaling pathwayGO:0332099.6AIM2, TNF
16positive regulation of peptidyl-serine phosphorylationGO:0331389.5IL6, TNF
17negative regulation of cell proliferationGO:0082859.4TNF, IFNK, IL6, IL1A
18positive regulation of NF-kappaB transcription factor activityGO:0510929.3TNF, IL6, AIM2
19inflammatory responseGO:0069549.0IL1A, AIM2, TNF, IL6

Molecular functions related to Skin Conditions according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.2IL1A, IL6, IFNK, TNF

Products for genes affiliated with Skin Conditions

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  • Antibodies
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Sources for Skin Conditions

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet