MCID: SKN027
MIFTS: 42

Skin Conditions malady

Skin diseases category

Summaries for Skin Conditions

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MedlinePlus:34 Your skin is your body's largest organ. it covers and protects your body. your skin holds body fluids in, preventing dehydration keeps harmful microbes out, preventing infections helps you feel things like heat, cold, and pain keeps your body temperature even makes vitamin d when the sun shines on it anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling, burning, and itching. allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. many skin problems, such as acne, also affect your appearance. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Skin Conditions is related to skin disease and psoriasis. An important gene associated with Skin Conditions is IL1A (interleukin 1, alpha), and among its related pathways are Downstream signaling in naive CD8+ T cells and Prion diseases. The drugs menthol and prednisolone and the compounds rantes and tocilizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and pancreas.

Aliases & Classifications for Skin Conditions

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Skin Conditions, Aliases & Descriptions:

Name: Skin Conditions 32 34 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Skin Conditions

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Diseases related to Skin Conditions via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1skin disease30.0IL1A, DCD, TNF
2psoriasis29.9TNF, IL6, IL1A
3psoriatic arthritis29.8IL1A, TNF
4dermatitis10.3
5atopic dermatitis10.2
6pulpitis10.0IL1A
7malaria10.0TNF
8crohn's disease10.0TNF
9thrombocytosis10.0IL1A, IL6
10crouzon syndrome with acanthosis nigricans10.0
11darier disease10.0
12angioma serpiginosum10.0
13follicular mucinosis10.0
14dowling-degos disease10.0
15contact dermatitis10.0
16chorioamnionitis10.0IL6, TNF
17alcoholic hepatitis10.0IL1A, TNF
18acute respiratory distress syndrome10.0IL6, TNF
19respiratory failure10.0IL6, TNF
20peritonitis10.0IL6, TNF
21uveitis10.0IL1A, TNF
22connective tissue disease10.0IL6, TNF
23juvenile rheumatoid arthritis10.0IL1A, IL6, TNF
24periodontitis10.0TNF, IL6, IL1A
25synovitis10.0IL1A, IL6, TNF
26periodontal disease10.0IL1A, IL6, TNF
27vascular disease10.0TNF, IL6, IL1A
28ulcerative colitis10.0IL1A, IL6, TNF
29osteoarthritis10.0TNF, IL6, IL1A
30monocytic leukemia10.0IL6, TNF
31systemic lupus erythematosus10.0TNF, IL6, CD247
32arthritis10.0TNF, IL6, IL1A
33viral infectious disease9.9TNF, IFNK, IL6, CD247
34hypersensitivity reaction type ii disease9.9CD247, IL1A, IL6, TNF
35melanoma9.9CD247, IL1A, TNF, AIM2
36leukemia9.9TNF, IL6, IL1A, CD247
37erythrokeratodermia variabilis et progressiva9.8
38ichthyosis vulgaris9.8
39muir-torre syndrome9.8
40netherton syndrome9.8
41rothmund-thomson syndrome9.8
42pityriasis rubra pilaris9.8
43ichthyosis, x-linked9.8
44keratosis follicularis spinulosa decalvans, x-linked9.8
45immunodysregulation, polyendocrinopathy, and enteropathy, x-linked9.8
46transient bullous of the newborn9.8
47hailey-hailey disease9.8
48ichthyosis with confetti9.8
49acne9.8
50rosacea9.8

Graphical network of the top 20 diseases related to Skin Conditions:



Diseases related to skin conditions

Symptoms for Skin Conditions

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Drugs & Therapeutics for Skin Conditions

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Genetic Tests for Skin Conditions

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Anatomical Context for Skin Conditions

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MalaCards organs/tissues related to Skin Conditions:

33
Skin, T cells, Pancreas

Animal Models for Skin Conditions or affiliated genes

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Publications for Skin Conditions

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Articles related to Skin Conditions:

(show all 49)
idTitleAuthorsYear
1
Laser treatment of periocular skin conditions. (25704939)
2015
2
A review of skin conditions in modern warfare and peacekeeping operations. (25562855)
2015
3
Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study. (25834304)
2015
4
Occlusive gloves and skin conditions: is there a problem? Results of a cross-sectional study in a semiconductor company. (25319754)
2015
5
Angioma serpiginosum: report of two cases suggesting type 1 mosaicism and proposal of adding it to the list of mosaic skin conditions. (25711206)
2015
6
Relationship Between Psychosocial Burden of Skin Conditions and Symptoms: Measuring the Attributable Fraction. (25766753)
2015
7
Association between skin conditions and depressive disorders in community-dwelling older adults. (25008442)
2014
8
Tattoos and coincidental skin conditions: the example of lymphomatoid papulosis. (24841722)
2014
9
What should primary care providers know about pediatric skin conditions? A modified Delphi technique for curriculum development. (25087213)
2014
10
Retraction. Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. (24971365)
2014
11
Skin conditions in primary care: an analysis of referral demand. (24657024)
2014
12
Increasing use of non-traditional vehicles for psoriasis and other inflammatory skin conditions. (25244174)
2014
13
EQ-5D in skin conditions: an assessment of validity and responsiveness. (25358263)
2014
14
Infective skin conditions in an adult sea-going population. (24881427)
2014
15
Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions. (24909886)
2014
16
Follicular mucinosis associated with nonlymphoid skin conditions. (25072678)
2014
17
Topical photodynamic therapy for non-malignant skin conditions: experience from a university teaching hospital. (24517855)
2014
18
Skin conditions in community-living older adults: prevalence and characteristics of medical care service use. (24800707)
2014
19
Quality of life in pediatric patients before and after cosmetic camouflage of visible skin conditions. (25218434)
2014
20
Idiopathic hypereosinophilic syndrome with multiple organ infarction: improvement of the skin condition masking the course of disease. (24667633)
2014
21
Therapeutic use of stories for children with atopic eczema and other chronic skin conditions. (24069961)
2013
22
Follicular Mucinosis Associated With Nonlymphoid Skin Conditions. (24061405)
2013
23
Daily intake of Jeju groundwater improves the skin condition of the model mouse for human atopic dermatitis. (23294459)
2013
24
Pyoderma gangrenosum - a frequently misdiagnosed skin condition. (24033196)
2013
25
Sparassis crispa (Hanabiratake) ameliorates skin conditions in rats and humans. (24018675)
2013
26
Aberrant distribution patterns of corneodesmosomal components of tape-stripped corneocytes in atopic dermatitis and related skin conditions (ichthyosis vulgaris, Netherton syndrome and peeling skin syndrome type B). (23810772)
2013
27
The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions. (24166134)
2013
28
Altered expression of antimicrobial peptide genes in the skin of dogs with atopic dermatitis and other inflammatory skin conditions. (23701024)
2013
29
Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. (24078929)
2013
30
Will epigenetics change our approach to treating skin conditions? (24517043)
2013
31
Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear. (22726258)
2012
32
Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions. (23171461)
2012
33
Use of frozen poloxamer as a base for Itchy skin conditions, including irritant contact dermatitis. (21781082)
2011
34
Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (21454693)
2011
35
Identifying when therapy for one skin disease is likely to exacerbate another skin condition. (21768483)
2011
36
New horny layer marker proteins for evaluating skin condition in atopic dermatitis. (19339807)
2009
37
Lobomycosis-like disease and other skin conditions in Indo-Pacific bottlenose dolphins Tursiops aduncus from the Indian Ocean. (19476285)
2009
38
Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas. (18414166)
2008
39
Urticaria and urticaria related skin condition/disease in children. (18700329)
2008
40
An overview of molluscum contagiosum: a viral skin condition. (18616033)
2008
41
Analysis of IFN-kappa expression in pathologic skin conditions: downregulation in psoriasis and atopic dermatitis. (16542135)
2006
42
Ivermectin improves the skin condition and self-esteem of females with onchocerciasis: a report of two cases. (15257804)
2004
43
Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions. (15377337)
2004
44
Absent or low expression of T-cell receptor zeta-chain in T cells infiltrating human pathological skin conditions. (12420108)
2002
45
A noninvasive method to assess skin irritation and compromised skin conditions using simple tape adsorption of molecular markers of inflammation. (11737818)
2001
46
The prevalence of common skin conditions in Australian school students: 4 Tinea pedis. (10354029)
1999
47
Interleukin-1 alpha- and beta-, interleukin-6- and tumour necrosis factor-alpha-like immunoreactivities in chronic granulomatous skin conditions. (7701874)
1994
48
Neurodermatitis: a skin condition that affects surgical wound healing. (893969)
1977
49
SOME SKIN CONDITIONS: ECZEMA AND IMPETIGO CONTAGIOSA. (14156185)
1964

Variations for Skin Conditions

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Expression for genes affiliated with Skin Conditions

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Search GEO for disease gene expression data for Skin Conditions.

Pathways for genes affiliated with Skin Conditions

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Pathways related to Skin Conditions according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.9CD247, TNF
29.8IL1A, IL6
39.8IL6, TNF
49.8IL6, TNF
59.8IL6, TNF
69.8TNF, IL6
79.8TNF, IL6
8
Show member pathways
IL27-mediated signaling events38
9.8TNF, IL6
9
Show member pathways
9.5IL1A, IL6, TNF
109.5IL1A, IL6, TNF
11
Show member pathways
9.5TNF, IL6, IL1A
12
Show member pathways
9.5IL1A, IL6, TNF
139.5IL1A, IL6, TNF
14
Show member pathways
9.5TNF, IL6, IL1A
15
Show member pathways
9.5IL1A, IL6, TNF
169.5TNF, IL6, IL1A
179.5IL1A, IL6, TNF
189.5IL1A, IL6, TNF
199.5IL1A, IL6, TNF
209.5TNF, IL6, IL1A
21
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5TNF, IL6, IL1A
229.5TNF, IL6, IL1A
239.5IL1A, IL6, TNF
24
Show member pathways
Immune response MIF in innate immunity response60
9.5IL1A, IL6, TNF
259.5TNF, IL6, IL1A
26
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.5TNF, IL6, CD247
27
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.5TNF, IL6, CD247
28
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.2TNF, IL6, IL1A, CD247
29
Show member pathways
9.2TNF, IFNK, IL6, IL1A
30
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.2TNF, IFNK, IL6, IL1A
31
Show member pathways
9.0AIM2, TNF, IL6

Compounds for genes affiliated with Skin Conditions

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Compounds related to Skin Conditions according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1rantes4510.5IL1A
2tocilizumab45 1311.2TNF, IL6
3gold sodium thiomalate4510.2IL1A, TNF
4abatacept45 1311.2IL6, TNF
5cdp5714510.2TNF, IL6
6anakinra45 1311.2IL6, TNF
7taurine chloramine4510.2IL6, TNF
8vesnarinone4510.2IL6, TNF
9gabexate mesilate4510.2TNF, IL6
10ulinastatin4510.2IL6, TNF
11mip 1alpha4510.2IL6, TNF
12il-124510.1IL6, TNF
13adalimumab45 51 1312.1IL6, TNF
14tpck4510.1TNF, IL6
15leflunomide45 51 1312.1TNF, IL6
16okt34510.1TNF, IL6
17sulfasalazine30 45 51 1313.0TNF, IL1A
18triptolide4510.0TNF, IL6
19ciglitazone45 3011.0IL6, TNF
20parthenolide45 311.0IL6, TNF
21tenidap45 3011.0IL1A, IL6, TNF
22imiquimod45 61 30 1313.0IL1A, IL6, TNF
23polymyxin b4510.0TNF, IL6, IL1A
24groalpha4510.0IL1A, IL6, TNF
25gm-csf45 3011.0IL1A, IL6, TNF
26polyinosinic-polycytidylic acid4510.0TNF, IL6, IL1A
27il 104510.0IL1A, IL6, TNF
28ivig4510.0IL1A, IL6, TNF
29lipoteichoic acid4510.0TNF, IL6
30pentoxifylline45 1311.0IL1A, IL6, TNF
31ccl345 3011.0IL1A, IL6, TNF
32neopterin4510.0TNF, IL6, IL1A
33pdtc459.9TNF, IL6, IL1A
34ns 39845 6110.9IL1A, TNF
35thalidomide45 51 61 1312.9IL1A, IL6, TNF
36leukotriene b445 61 2611.9IL1A, IL6, TNF
37hydrocortisone45 3 61 1312.9TNF, IL6, IL1A
388-isoprostane459.9IL6, TNF
39simvastatin45 51 61 30 26 1314.9TNF, IL6, IL1A
40herbimycin a45 6110.9TNF, IL6, IL1A
41endotoxin459.9TNF, IL6, IL1A
42curcumin459.9IL1A, IL6, TNF
43prostaglandin459.9TNF, IL6, IL1A
44calcitriol45 61 26 1312.9IL1A, IL6, TNF
45methylcellulose459.8IL1A, IL6
46indomethacin45 30 61 1312.8IL1A, IL6, TNF
472,5-oligoadenylate459.8TNF, IL6
48sb 20358045 6110.8IL1A, IL6, TNF
49etanercept45 51 1311.7IL6, TNF
50poly(i-c)459.5IL6, TNF

GO Terms for genes affiliated with Skin Conditions

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Cellular components related to Skin Conditions according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.7IL1A, IL6, IFNK, TNF, IGFL1
2extracellular regionGO:00055767.2IL1A, IGFL3, IGFL2, TNF, DCD, IFNK

Biological processes related to Skin Conditions according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:005071510.1IL1A, TNF
2negative regulation of lipid storageGO:001088810.1IL6, TNF
3epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.1IL6, TNF
4positive regulation of chemokine productionGO:003272210.1TNF, IL6
5positive regulation of mitosisGO:004584010.1IL1A, TNF
6negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:0200124010.0IL1A, TNF
7positive regulation of nitric oxide biosynthetic processGO:004542910.0TNF, IL6
8defense response to Gram-positive bacteriumGO:00508309.9TNF, IL6
9negative regulation of fat cell differentiationGO:00455999.9IL6, TNF
10positive regulation of interleukin-6 productionGO:00327559.8IL6, TNF
11response to mechanical stimulusGO:00096129.8IL6, TNF
12humoral immune responseGO:00069599.8IL6, IFNK, TNF
13cytokine-mediated signaling pathwayGO:00192219.7IFNK, IL6, IL1A
14positive regulation of smooth muscle cell proliferationGO:00486619.7TNF, IL6
15tumor necrosis factor-mediated signaling pathwayGO:00332099.6TNF, AIM2
16positive regulation of peptidyl-serine phosphorylationGO:00331389.5IL6, TNF
17negative regulation of cell proliferationGO:00082859.4TNF, IFNK, IL6, IL1A
18positive regulation of NF-kappaB transcription factor activityGO:00510929.3IL6, TNF, AIM2
19inflammatory responseGO:00069549.0AIM2, TNF, IL6, IL1A

Molecular functions related to Skin Conditions according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.2IL1A, IL6, IFNK, TNF

Products for genes affiliated with Skin Conditions

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Sources for Skin Conditions

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet