MCID: SKN027
MIFTS: 38

Skin Conditions malady

Skin diseases category

Summaries for Skin Conditions

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MedlinePlus:32 Your skin is your body's largest organ. it covers and protects your body. your skin holds body fluids in, preventing dehydration keeps harmful microbes out, preventing infections helps you feel things like heat, cold, and pain keeps your body temperature even makes vitamin d when the sun shines on it anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling, burning, and itching. allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. many skin problems, such as acne, also affect your appearance. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Skin Conditions, also known as dermatologic disorders, is related to psoriatic arthritis and skin disease. An important gene associated with Skin Conditions is IL1A (interleukin 1, alpha), and among its related pathways are Downstream signaling in naive CD8+ T cells and Prion diseases. The drugs alitretinoin and prednisone and the compounds rantes and tocilizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and pancreas.

Aliases & Classifications for Skin Conditions

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Skin Conditions, Aliases & Descriptions:

Name: Skin Conditions 30 32
 
Dermatologic Disorders 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Skin Conditions

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Diseases related to Skin Conditions via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis29.8IL1A, TNF
2skin disease29.7IL1A, DCD, TNF
3psoriasis29.6IL1A, IL6, TNF
4pulpitis10.4IL1A
5dermatitis10.3
6malaria10.2TNF
7atopic dermatitis10.2
8crohn's disease10.1TNF
9thrombocytosis10.1IL1A, IL6
10chorioamnionitis10.0TNF, IL6
11alcoholic hepatitis10.0TNF, IL1A
12crouzon syndrome with acanthosis nigricans10.0
13darier disease10.0
14angioma serpiginosum10.0
15follicular mucinosis10.0
16dowling-degos disease10.0
17contact dermatitis10.0
18acute respiratory distress syndrome10.0IL6, TNF
19respiratory failure10.0IL6, TNF
20peritonitis9.9IL6, TNF
21uveitis9.9IL1A, TNF
22connective tissue disease9.9IL6, TNF
23erythrokeratodermia variabilis et progressiva9.8
24ichthyosis vulgaris9.8
25muir-torre syndrome9.8
26netherton syndrome9.8
27rothmund-thomson syndrome9.8
28pityriasis rubra pilaris9.8
29ichthyosis, x-linked9.8
30keratosis follicularis spinulosa decalvans, x-linked9.8
31immunodysregulation, polyendocrinopathy, and enteropathy, x-linked9.8
32transient bullous of the newborn9.8
33hailey-hailey disease9.8
34ichthyosis with confetti9.8
35acne9.8
36rosacea9.8
37molluscum contagiosum9.8
38tuberculoid leprosy9.8
39borderline leprosy9.8
40dyshidrosis9.8
41lepromatous leprosy9.8
42onchocerciasis9.8
43pyoderma gangrenosum9.8
44acinar cell carcinoma9.8
45erythema multiforme9.8
46neurodermatitis9.8
47balanitis xerotica obliterans9.8
48necrobiosis lipoidica9.8
49congenital generalized lipodystrophy9.8
50tinea pedis9.8

Graphical network of the top 20 diseases related to Skin Conditions:



Diseases related to skin conditions

Symptoms for Skin Conditions

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Drugs & Therapeutics for Skin Conditions

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Genetic Tests for Skin Conditions

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Anatomical Context for Skin Conditions

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MalaCards organs/tissues related to Skin Conditions:

31
Skin, T cells, Pancreas

Animal Models for Skin Conditions or affiliated genes

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Publications for Skin Conditions

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Articles related to Skin Conditions:

(show all 49)
idTitleAuthorsYear
1
Laser treatment of periocular skin conditions. (25704939)
2015
2
A review of skin conditions in modern warfare and peacekeeping operations. (25562855)
2015
3
Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study. (25834304)
2015
4
Occlusive gloves and skin conditions: is there a problem? Results of a cross-sectional study in a semiconductor company. (25319754)
2015
5
Angioma serpiginosum: report of two cases suggesting type 1 mosaicism and proposal of adding it to the list of mosaic skin conditions. (25711206)
2015
6
Relationship Between Psychosocial Burden of Skin Conditions and Symptoms: Measuring the Attributable Fraction. (25766753)
2015
7
Association between skin conditions and depressive disorders in community-dwelling older adults. (25008442)
2014
8
Tattoos and coincidental skin conditions: the example of lymphomatoid papulosis. (24841722)
2014
9
What should primary care providers know about pediatric skin conditions? A modified Delphi technique for curriculum development. (25087213)
2014
10
Retraction. Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. (24971365)
2014
11
Skin conditions in primary care: an analysis of referral demand. (24657024)
2014
12
Increasing use of non-traditional vehicles for psoriasis and other inflammatory skin conditions. (25244174)
2014
13
EQ-5D in skin conditions: an assessment of validity and responsiveness. (25358263)
2014
14
Infective skin conditions in an adult sea-going population. (24881427)
2014
15
Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions. (24909886)
2014
16
Follicular mucinosis associated with nonlymphoid skin conditions. (25072678)
2014
17
Topical photodynamic therapy for non-malignant skin conditions: experience from a university teaching hospital. (24517855)
2014
18
Skin conditions in community-living older adults: prevalence and characteristics of medical care service use. (24800707)
2014
19
Quality of life in pediatric patients before and after cosmetic camouflage of visible skin conditions. (25218434)
2014
20
Idiopathic hypereosinophilic syndrome with multiple organ infarction: improvement of the skin condition masking the course of disease. (24667633)
2014
21
Therapeutic use of stories for children with atopic eczema and other chronic skin conditions. (24069961)
2013
22
Follicular Mucinosis Associated With Nonlymphoid Skin Conditions. (24061405)
2013
23
Daily intake of Jeju groundwater improves the skin condition of the model mouse for human atopic dermatitis. (23294459)
2013
24
Pyoderma gangrenosum - a frequently misdiagnosed skin condition. (24033196)
2013
25
Sparassis crispa (Hanabiratake) ameliorates skin conditions in rats and humans. (24018675)
2013
26
Aberrant distribution patterns of corneodesmosomal components of tape-stripped corneocytes in atopic dermatitis and related skin conditions (ichthyosis vulgaris, Netherton syndrome and peeling skin syndrome type B). (23810772)
2013
27
The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions. (24166134)
2013
28
Altered expression of antimicrobial peptide genes in the skin of dogs with atopic dermatitis and other inflammatory skin conditions. (23701024)
2013
29
Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings. (24078929)
2013
30
Will epigenetics change our approach to treating skin conditions? (24517043)
2013
31
Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear. (22726258)
2012
32
Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions. (23171461)
2012
33
Use of frozen poloxamer as a base for Itchy skin conditions, including irritant contact dermatitis. (21781082)
2011
34
Murine IGFL and human IGFL1 are induced in inflammatory skin conditions and bind to a novel TNF receptor family member, IGFLR1. (21454693)
2011
35
Identifying when therapy for one skin disease is likely to exacerbate another skin condition. (21768483)
2011
36
New horny layer marker proteins for evaluating skin condition in atopic dermatitis. (19339807)
2009
37
Lobomycosis-like disease and other skin conditions in Indo-Pacific bottlenose dolphins Tursiops aduncus from the Indian Ocean. (19476285)
2009
38
Necrotizing panniculitis: a skin condition associated with acinar cell carcinoma of the pancreas. (18414166)
2008
39
Urticaria and urticaria related skin condition/disease in children. (18700329)
2008
40
An overview of molluscum contagiosum: a viral skin condition. (18616033)
2008
41
Analysis of IFN-kappa expression in pathologic skin conditions: downregulation in psoriasis and atopic dermatitis. (16542135)
2006
42
Ivermectin improves the skin condition and self-esteem of females with onchocerciasis: a report of two cases. (15257804)
2004
43
Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions. (15377337)
2004
44
Absent or low expression of T-cell receptor zeta-chain in T cells infiltrating human pathological skin conditions. (12420108)
2002
45
A noninvasive method to assess skin irritation and compromised skin conditions using simple tape adsorption of molecular markers of inflammation. (11737818)
2001
46
The prevalence of common skin conditions in Australian school students: 4 Tinea pedis. (10354029)
1999
47
Interleukin-1 alpha- and beta-, interleukin-6- and tumour necrosis factor-alpha-like immunoreactivities in chronic granulomatous skin conditions. (7701874)
1994
48
Neurodermatitis: a skin condition that affects surgical wound healing. (893969)
1977
49
SOME SKIN CONDITIONS: ECZEMA AND IMPETIGO CONTAGIOSA. (14156185)
1964

Variations for Skin Conditions

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Expression for genes affiliated with Skin Conditions

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Search GEO for disease gene expression data for Skin Conditions.

Pathways for genes affiliated with Skin Conditions

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Pathways related to Skin Conditions according to GeneCards Suite gene sharing:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.9CD247, TNF
29.8IL1A, IL6
39.8IL6, TNF
49.8IL6, TNF
59.8IL6, TNF
69.8TNF, IL6
79.8TNF, IL6
8
Show member pathways
IL27-mediated signaling events36
9.8TNF, IL6
9
Show member pathways
9.5IL1A, IL6, TNF
109.5IL1A, IL6, TNF
11
Show member pathways
9.5TNF, IL6, IL1A
12
Show member pathways
9.5IL1A, IL6, TNF
139.5IL1A, IL6, TNF
14
Show member pathways
9.5TNF, IL6, IL1A
15
Show member pathways
9.5IL1A, IL6, TNF
169.5TNF, IL6, IL1A
179.5IL1A, IL6, TNF
189.5IL1A, IL6, TNF
199.5IL1A, IL6, TNF
209.5TNF, IL6, IL1A
21
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.5TNF, IL6, IL1A
229.5TNF, IL6, IL1A
239.5IL1A, IL6, TNF
24
Show member pathways
Immune response MIF in innate immunity response58
9.5IL1A, IL6, TNF
259.5TNF, IL6, IL1A
26
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.5TNF, IL6, CD247
27
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.5TNF, IL6, CD247
28
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.2TNF, IL6, IL1A, CD247
29
Show member pathways
9.2TNF, IFNK, IL6, IL1A
30
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.2TNF, IFNK, IL6, IL1A
31
Show member pathways
9.0AIM2, TNF, IL6

Compounds for genes affiliated with Skin Conditions

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Compounds related to Skin Conditions according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1rantes4310.5IL1A
2tocilizumab43 1211.2TNF, IL6
3gold sodium thiomalate4310.2IL1A, TNF
4abatacept43 1211.2IL6, TNF
5cdp5714310.2TNF, IL6
6anakinra43 1211.2IL6, TNF
7taurine chloramine4310.2IL6, TNF
8vesnarinone4310.2IL6, TNF
9gabexate mesilate4310.2TNF, IL6
10ulinastatin4310.2IL6, TNF
11mip 1alpha4310.2IL6, TNF
12il-124310.1IL6, TNF
13adalimumab43 49 1212.1IL6, TNF
14tpck4310.1TNF, IL6
15leflunomide43 49 1212.1TNF, IL6
16okt34310.1TNF, IL6
17sulfasalazine28 43 49 1213.0TNF, IL1A
18triptolide4310.0TNF, IL6
19ciglitazone43 2811.0IL6, TNF
20parthenolide43 211.0IL6, TNF
21tenidap43 2811.0IL1A, IL6, TNF
22imiquimod43 59 28 1213.0IL1A, IL6, TNF
23polymyxin b4310.0TNF, IL6, IL1A
24groalpha4310.0IL1A, IL6, TNF
25gm-csf43 2811.0IL1A, IL6, TNF
26polyinosinic-polycytidylic acid4310.0TNF, IL6, IL1A
27il 104310.0IL1A, IL6, TNF
28ivig4310.0IL1A, IL6, TNF
29lipoteichoic acid4310.0TNF, IL6
30pentoxifylline43 1211.0IL1A, IL6, TNF
31ccl343 2811.0IL1A, IL6, TNF
32neopterin4310.0TNF, IL6, IL1A
33pdtc439.9TNF, IL6, IL1A
34ns 39843 5910.9IL1A, TNF
35thalidomide43 49 59 1212.9IL1A, IL6, TNF
36leukotriene b443 59 2411.9IL1A, IL6, TNF
37hydrocortisone43 2 59 1212.9TNF, IL6, IL1A
388-isoprostane439.9IL6, TNF
39simvastatin43 49 59 28 24 1214.9TNF, IL6, IL1A
40herbimycin a43 5910.9TNF, IL6, IL1A
41endotoxin439.9TNF, IL6, IL1A
42curcumin439.9IL1A, IL6, TNF
43prostaglandin439.9TNF, IL6, IL1A
44calcitriol43 59 24 1212.9IL1A, IL6, TNF
45methylcellulose439.8IL1A, IL6
46indomethacin43 28 59 1212.8IL1A, IL6, TNF
472,5-oligoadenylate439.8TNF, IL6
48sb 20358043 5910.8IL1A, IL6, TNF
49etanercept43 49 1211.7IL6, TNF
50poly(i-c)439.5IL6, TNF

GO Terms for genes affiliated with Skin Conditions

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Cellular components related to Skin Conditions according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.7IL1A, IL6, IFNK, TNF, IGFL1
2extracellular regionGO:00055767.2IL1A, IGFL3, IGFL2, TNF, DCD, IFNK

Biological processes related to Skin Conditions according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine secretionGO:005071510.1IL1A, TNF
2negative regulation of lipid storageGO:001088810.1IL6, TNF
3epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.1IL6, TNF
4positive regulation of chemokine productionGO:003272210.1TNF, IL6
5positive regulation of mitosisGO:004584010.1IL1A, TNF
6negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:0200124010.0IL1A, TNF
7positive regulation of nitric oxide biosynthetic processGO:004542910.0TNF, IL6
8defense response to Gram-positive bacteriumGO:00508309.9TNF, IL6
9negative regulation of fat cell differentiationGO:00455999.9IL6, TNF
10positive regulation of interleukin-6 productionGO:00327559.8IL6, TNF
11response to mechanical stimulusGO:00096129.8IL6, TNF
12humoral immune responseGO:00069599.8IL6, IFNK, TNF
13cytokine-mediated signaling pathwayGO:00192219.7IFNK, IL6, IL1A
14positive regulation of smooth muscle cell proliferationGO:00486619.7TNF, IL6
15tumor necrosis factor-mediated signaling pathwayGO:00332099.6TNF, AIM2
16positive regulation of peptidyl-serine phosphorylationGO:00331389.5IL6, TNF
17negative regulation of cell proliferationGO:00082859.4TNF, IFNK, IL6, IL1A
18positive regulation of NF-kappaB transcription factor activityGO:00510929.3IL6, TNF, AIM2
19inflammatory responseGO:00069549.0AIM2, TNF, IL6, IL1A

Molecular functions related to Skin Conditions according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.2IL1A, IL6, IFNK, TNF

Products for genes affiliated with Skin Conditions

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Sources for Skin Conditions

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet