MCID: SKN016
MIFTS: 64

Skin Disease malady

Skin diseases category

Summaries for Skin Disease

About this section


Disease Ontology:9 An integumentary system disease that is located in skin.

MalaCards based summary: Skin Disease, also known as dermatitis due to unspecified substance taken internally, is related to bullous skin disease and bullous pemphigoid. An important gene associated with Skin Disease is LAMC2 (laminin, gamma 2), and among its related pathways are a6b1 and a6b4 Integrin signaling and Cytokine Network. The drugs menthol and prednisolone and the compounds ena 78 and rebamipide have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are digestive/alimentary and integument.

Aliases & Classifications for Skin Disease

About this section

Skin Disease, Aliases & Descriptions:

Name: Skin Disease 30 9 11
Dermatitis Due to Unspecified Substance Taken Internally 9
Dermatitis Due to Substances Taken Internally 9
Skin and Subcutaneous Tissue Disease 9
Dermatologic Disorders 60
Skin Diseases, Genetic 60
 
Skin Diseases Genetic 43
Genetic Skin Disease 9
Genodermatosis, Nos 9
Genodermatosis 9
Skin Diseases 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Skin Disease

About this section

Diseases related to Skin Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1022)
idRelated DiseaseScoreTop Affiliating Genes
1bullous skin disease31.0DST, COL17A1, CCL5
2bullous pemphigoid30.8ITGA6, DST, COL17A1
3cicatricial pemphigoid30.7COL17A1
4arthritis30.7TNF, IL8
5psoriasis30.6CDSN, IL8, CCL5, DST, TNF
6herpes gestationis30.4DST, COL17A1
7atopic dermatitis30.3TNF, IL8, ITGA6, CCL5, CDSN
8epidermolysis bullosa acquisita30.3LAMC2, DST, COL17A1
9epidermolysis bullosa, junctional, non-herlitz type30.2COL17A1, DST
10spondyloarthropathy 130.2TNF
11epidermolysis bullosa30.1ITGA6, COL17A1, LAMC2, DST
12behcet's disease30.1IL8, TNF
13lichen planus30.1DST, LAMC2, COL17A1
14basal cell carcinoma30.0LAMC2, DST, COL17A1
15osteoarthritis29.7TNF, CCL5, ITGA6, IL8
16ectodermal dysplasia 2, clouston type29.7GJB3, GJB4
17erythrokeratodermia variabilis et progressiva29.7GJB3, GJB4
18melanoma29.6LAMC2, IL8, ITGA6, DST, TNF
19ocular cicatricial pemphigoid10.5ITGA6
20periapical granuloma10.5CCL5
21junctional epidermolysis bullosa10.5COL17A1, LAMC2
22dermatitis10.4
23epidermolysis bullosa simplex10.4DST, COL17A1
24viral meningitis10.4CCL5, IL8
25alcoholic hepatitis10.4TNF, IL8
26vernal keratoconjunctivitis10.3IL8, CCL5
27chorioamnionitis10.3TNF, IL8
28extrinsic allergic alveolitis10.3IL8, CCL5
29acne10.3
30bronchiolitis10.3IL8, CCL5
31pulmonary fibrosis, idiopathic10.3CCL5, IL8, LAMC2
32periodontal disease10.3TNF, IL8, LAMC2
33demyelinating disease10.3TNF, CCL5
34allergic contact dermatitis10.3
35contact dermatitis10.3
36granulomatous slack skin disease10.3
37interstitial lung disease10.3IL8, CCL5
38endometriosis10.2CCL5, IL8, ITGA6
39irritant dermatitis10.2
40lupus erythematosus10.2
41pulmonary sarcoidosis10.2CCL5, TNF
42pulmonary disease, chronic obstructive10.2IL8, CCL5, TNF
43pemphigus10.2
44cork-handlers' disease10.2IL8, TNF, CCL5
45pneumonia10.2TNF, IL8, CCL5
46acute respiratory distress syndrome10.1IL8, TNF
47hypersensitivity reaction type ii disease10.1CCL5, DST, TNF, COL17A1
48scleroderma10.1
49ulcerative colitis10.1IL8, LAMC2, TNF
50rosacea10.1

Graphical network of the top 20 diseases related to Skin Disease:



Diseases related to skin disease

Symptoms for Skin Disease

About this section

Drugs & Therapeutics for Skin Disease

About this section

Drug clinical trials:

Search ClinicalTrials for Skin Disease

Search NIH Clinical Center for Skin Disease

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Skin Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Skin Disease:
JACE
Embryonic/Adult Cultured Cells Related to Skin Disease:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Skin Disease

About this section

Anatomical Context for Skin Disease

About this section

MalaCards organs/tissues related to Skin Disease:

31
Skin, T cells, Testes, Neutrophil, Eye, Bone, Endothelial, Colon, Kidney, Bone marrow, Thymus, Liver, Lung, Thyroid, Myeloid, Monocytes, B cells

FMA organs/tissues related to Skin Disease:

14
Skin

Animal Models for Skin Disease or affiliated genes

About this section

MGI Mouse Phenotypes related to Skin Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9TNF, LAMC2, DST, ITGA6, IQGAP1
2MP:00107718.6CDSN, TNF, LAMC2, DST, ITGA6, COL17A1
3MP:00053878.5TNF, LAMC2, CCL5, ITGA6, IL8, COL17A1
4MP:00107688.4LAMC2, DST, ITGA6, IQGAP1, COL17A1, GJB3

Publications for Skin Disease

About this section

Articles related to Skin Disease:

(show top 50)    (show all 693)
idTitleAuthorsYear
1
Hidradenitis Suppurativa: New Opportunities for an Orphan Skin Disease. (25796270)
2015
2
Association with Genetic Variants in the IL-23 and NF-I_B Pathways Discriminates between Mild and Severe Psoriasis Skin Disease. (25789703)
2015
3
Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis in the absence of skin disease. (25275766)
2014
4
Phase I study protocol for ex-vivo lentiviral gene therapy for the inherited skin disease, Netherton Syndrome. (24138501)
2013
5
IgG4-related skin disease successfully treated by thalidomide: a report of 2 cases with emphasis on pathological aspects. (23572226)
2013
6
Tungiasis - A Janus-faced parasitic skin disease. (24211240)
2013
7
Lumpy skin disease of cattle: an emerging problem in the Sultanate of Oman. (24097247)
2013
8
Analysis of high-dose intravenous immunoglobulin therapy in 16 patients with refractory autoimmune blistering skin disease: high efficacy and no serious adverse events. (23073990)
2013
9
Skin disease in individuals with liver and kidney transplants: influence of skin phototype and transplanted organ. (23895208)
2013
10
Genetic skin diseases predisposing to basal cell carcinoma. (22391625)
2012
11
Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. (22930385)
2012
12
Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. (22615377)
2012
13
Skin disease in dermatomyositis. (22907594)
2012
14
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (21839423)
2011
15
Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down. (22103940)
2011
16
Neutrophils require SHP1 to regulate IL-1I^ production and prevent inflammatory skin disease. (21160041)
2011
17
Usage of complementary and alternative medicine for management of skin disease. (21936703)
2011
18
Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases. (20636397)
2010
19
Dermatoses affecting desmosomes in animals: a mechanistic review of acantholytic blistering skin diseases. (20178467)
2009
20
Patients with skin disease and their relationships with their doctors: a qualitative study of patients with acne, psoriasis and eczema. (19236289)
2009
21
Is psoriasis a skin disease or a form of arthritis? (19768838)
2009
22
Connexin-26 mutations in deafness and skin disease. (19939300)
2009
23
Temporary tattoos to simulate skin disease: report and validation of a novel teaching tool. (19550194)
2009
24
Evaluation of the Cutaneous Lupus Activity and Severity Score in the assessment of lupus erythematosus skin disease. (17941937)
2008
25
Quantitative real-time RT-PCR measurement of cytokine mRNA expression in the skin of normal cats and cats with allergic skin disease. (18191230)
2008
26
Measurement of family impact of skin disease: further validation of the Family Dermatology Life Quality Index (FDLQI). (18312324)
2008
27
Meeting report of immunology and skin disease: new perspectives. (17632556)
2007
28
Therapy-resistent lupus skin disease successfully treated with rituximab. (16690759)
2006
29
Involving the patient: impact of inflammatory skin disease and patient-focused care. (15968267)
2005
30
Arthritis and skin disease. (16282751)
2005
31
The biology of Malassezia organisms and their ability to induce immune responses and skin disease. (15725101)
2005
32
The emotional impact of chronic and disabling skin disease: a psychoanalytic perspective. (16112437)
2005
33
Pimecrolimus for the treatment of inflammatory skin disease. (15013932)
2004
34
Defining the burden of skin disease in the United States--a historical perspective. (15083775)
2004
35
The allergy and immunology specialist: what is the role in the treatment of skin disease? (15576896)
2004
36
Prevalence of skin disease in HIV-positive pregnant women. (12839600)
2003
37
Use of a polymerase chain reaction assay to detect bovine herpesvirus type 2 DNA in skin lesions from cattle suspected to have pseudo-lumpy skin disease. (12762387)
2003
38
Etanercept ameliorates sarcoidosis arthritis and skin disease. (12913948)
2003
39
Implication of a healthcare worker with chronic skin disease in the transmission of an epidemic strain of methicillin-resistant Staphylococcus aureus in a pediatric intensive care unit. (12725361)
2003
40
Patients' and doctors' assessment of skin disease handicap. (12072021)
2002
41
Importance of thymidine kinase activity for normal growth of lumpy skin disease virus (SA-Neethling). (11958465)
2002
42
Lumpy skin disease in southern Africa: a review of the disease and aspects of control. (11513262)
2001
43
A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. (11590199)
2001
44
Questions answered and a $1 million question raised concerning lupus erythematosus tumidus: is routine laboratory surveillance testing during treatment with hydroxychloroquine for skin disease really necessary. (10926741)
2000
45
The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases. (10666397)
2000
46
Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. (10815854)
2000
47
Differential expression of CRABP II, psoriasin and cytokeratin 1 mRNA in human skin diseases. (8844119)
1996
48
Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases. (8763423)
1996
49
Development of interferon antibodies during the treatment of skin diseases with low-dose recombinant interferon alpha-2a]. (8597337)
1995
50
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990

Variations for Skin Disease

About this section

Expression for genes affiliated with Skin Disease

About this section
Search GEO for disease gene expression data for Skin Disease.

Pathways for genes affiliated with Skin Disease

About this section

Pathways related to Skin Disease according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0ITGA6, COL17A1
29.9TNF, IL8
39.9IL8, TNF
4
Show member pathways
9.7TNF, LAMC2, ITGA6
5
Show member pathways
9.7GJB3, GJB4
69.7IL8, LAMC2, TNF
79.6TNF, CCL5, IL8
8
Show member pathways
9.6TNF, CCL5, IL8
99.6TNF, CCL5, IL8
10
Show member pathways
9.6COL17A1, ITGA6, DST, LAMC2
11
Show member pathways
9.6LAMC2, DST, ITGA6, COL17A1
12
Show member pathways
9.6COL17A1, ITGA6, DST, LAMC2
13
Show member pathways
9.4TNF, CCL5, ITGA6, IL8
14
Show member pathways
9.4IL8, ITGA6, CCL5, TNF
15
Show member pathways
9.4CCL5, IL8, IQGAP1, TNF
16
Show member pathways
9.3COL17A1, IQGAP1, ITGA6, DST, LAMC2
17
Show member pathways
9.3LAMC2, CCL5, ITGA6, IL8, COL17A1
18
Show member pathways
8.7TNF, LAMC2, CCL5, ITGA6, IL8, IQGAP1

Compounds for genes affiliated with Skin Disease

About this section

Compounds related to Skin Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1ena 784310.4CCL5, IL8
2rebamipide4310.3IL8, CCL5
3loratadine43 24 1212.3CCL5, IL8
4cilomilast4310.3IL8, TNF
5mcp 14310.3CCL5, IL8
6n-tosyl-l-phenylalanine chloromethyl ketone4310.3IL8, TNF
7taurine chloramine4310.3IL8, TNF
8gabexate mesilate4310.3TNF, IL8
9ulinastatin4310.3TNF, IL8
10pranlukast43 28 1212.3CCL5, TNF
11toxin-14310.2TNF, IL8
12salmeterol43 49 28 1213.2IL8, CCL5
13kalinin4310.2ITGA6, DST, LAMC2
14gold sodium thiomalate4310.2IL8, TNF
15gold4310.1COL17A1, DST, LAMC2
16mip 1alpha4310.1IL8, CCL5, TNF
17groalpha4310.1TNF, CCL5, IL8
18aebsf4310.1TNF, IL8
19triptolide4310.1IL8, CCL5, TNF
20gm-csf43 2811.1IL8, CCL5, TNF
21budesonide43 49 1212.1TNF, CCL5, IL8
22fluticasone propionate43 49 59 1213.1IL8, CCL5, TNF
23poly(i-c)4310.1IL8, CCL5, TNF
24il 104310.1IL8, CCL5, TNF
25tarc4310.0IL8, CCL5, TNF
26peptidoglycan43 2811.0IL8, CCL5, TNF
27ccl343 2811.0TNF, CCL5, IL8
28pdtc4310.0IL8, CCL5, TNF
29leukotriene b443 59 2412.0IL8, CCL5, TNF
30sp 60012543 5911.0TNF, CCL5, IL8
315 aminosalicylic acid4310.0TNF, IL8
32gap 275910.0GJB4, GJB3
33hydrocortisone43 2 59 1213.0IL8, CCL5, TNF
34carbenoxolone disodium5910.0GJB4, GJB3
35scrambled 10panx5910.0GJB4, GJB3
3610panx5910.0GJB4, GJB3
37egcg4310.0TNF, CCL5, IL8
38il-124310.0TNF, IL8
39herbimycin a43 5911.0TNF, ITGA6, IL8
40simvastatin43 49 59 28 24 1214.9TNF, CCL5, IL8
41octanol28 2410.9GJB4, GJB3
42staurosporin439.9TNF, IL8
43endotoxin439.8IL8, CCL5, TNF
44pd 98,059439.8TNF, CCL5, ITGA6, IL8
45tpck439.8IL8, TNF
46fmlp439.8IL8, CCL5, TNF
47nacl439.7COL17A1, CCL5, DST
48imiquimod43 59 28 1212.6IL8, TNF
49cycloheximide439.6TNF, DST, CCL5, IL8, COL17A1
50serine439.2TNF, CCL5, IL8, IQGAP1, COL17A1, CDSN

GO Terms for genes affiliated with Skin Disease

About this section

Cellular components related to Skin Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basal plasma membraneGO:000992510.0ITGA6, DST
2hemidesmosomeGO:00300569.9COL17A1, ITGA6, DST
3basement membraneGO:00056049.8COL17A1, ITGA6, DST
4cell leading edgeGO:00312529.7IQGAP1, DST
5connexon complexGO:00059229.6GJB3, GJB4
6extracellular regionGO:00055768.9TNF, LAMC2, CCL5, IL8, COL17A1, CDSN

Biological processes related to Skin Disease according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of G-protein coupled receptor protein signaling pathwayGO:004574410.1CCL5, IL8
2neutrophil activationGO:004211910.1IL8, CCL5
3positive regulation of phosphorylationGO:004232710.1ITGA6, CCL5
4cellular response to fibroblast growth factor stimulusGO:004434410.1CCL5, IL8
5embryonic digestive tract developmentGO:004856610.1IL8, TNF
6cell junction assemblyGO:003432910.1COL17A1, ITGA6, LAMC2
7epidermis developmentGO:000854410.0CDSN, COL17A1, LAMC2
8cellular response to organic cyclic compoundGO:00714079.9TNF, CCL5, ITGA6
9lipopolysaccharide-mediated signaling pathwayGO:00316639.9CCL5, TNF
10negative regulation of viral genome replicationGO:00450719.9CCL5, TNF
11hemidesmosome assemblyGO:00315819.9COL17A1, ITGA6, DST, LAMC2
12protein kinase B signalingGO:00434919.8CCL5, TNF
13cell communicationGO:00071549.8GJB4, GJB3
14cellular response to interleukin-1GO:00713479.6IL8, CCL5
15extracellular matrix organizationGO:00301989.5TNF, LAMC2, DST, ITGA6, COL17A1

Products for genes affiliated with Skin Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Skin Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet