MCID: SKN016
MIFTS: 75

Skin Disease malady

Skin diseases category

Summaries for Skin Disease

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 A cutaneous condition is any medical condition that affects the integumentary system ? the organ system... more...

MalaCards: Skin Disease, also known as dermatitis due to unspecified substance taken internally, is related to psoriasis and bullous skin disease. An important gene associated with Skin Disease is LAMC2 (laminin, gamma 2), and among its related pathways are a6b1 and a6b4 Integrin signaling and Cytokine Network. The drugs prednisolone and prednisone and the compounds ena 78 and rebamipide have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are digestive/alimentary and integument.

Disease Ontology:9 An integumentary system disease that is located in skin.

Aliases & Classifications for Skin Disease

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Sources:
9Disease Ontology, 11DISEASES, 32LifeMap Discoveryā„¢, 46Novoseek, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

skin disease 9 11 32
dermatitis due to unspecified substance taken internally 9
dermatitis due to substances taken internally 9
skin and subcutaneous tissue disease 9
dermatologic disorders 63
skin diseases, genetic 63
skin diseases genetic 46
genetic skin disease 9
genodermatosis, nos 9
genodermatosis 9
skin diseases 46


Related Diseases for Skin Disease

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Skin Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1120)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.7TNF, DST, CCL5, IL8, CDSN
2bullous skin disease30.6COL17A1, CCL5, DST
3bullous pemphigoid30.4DST, ITGA6, COL17A1
4atopic dermatitis30.4TNF, CCL5, ITGA6, IL8, CDSN
5arthritis30.3TNF, IL8
6herpes gestationis30.0COL17A1, DST
7epidermolysis bullosa acquisita30.0LAMC2, DST, COL17A1
8cicatricial pemphigoid29.9COL17A1
9junctional epidermolysis bullosa29.9LAMC2, COL17A1
10epidermolysis bullosa simplex29.9DST, COL17A1
11lichen planus29.9COL17A1, DST, LAMC2
12epidermolysis bullosa29.8COL17A1, ITGA6, DST, LAMC2
13behcet's disease29.8IL8, TNF
14erythrokeratodermia variabilis29.8GJB3, GJB4
15junctional epidermolysis bullosa, non-herlitz type29.7DST, COL17A1
16ankylosing spondylitis29.7TNF
17basal cell carcinoma29.6COL17A1, DST, LAMC2
18osteoarthritis29.6TNF, CCL5, ITGA6, IL8
19clouston syndrome29.6GJB4, GJB3
20dermatitis10.4
21contact dermatitis10.3
22allergic contact dermatitis10.3
23irritant dermatitis10.2
24lupus erythematosus10.2
25acne10.2
26granulomatous slack skin disease10.2
27pemphigus10.2
28ocular cicatricial pemphigoid10.1ITGA6
29periapical granuloma10.1CCL5
30viral meningitis10.1CCL5, IL8
31alcoholic hepatitis10.1IL8, TNF
32vernal keratoconjunctivitis10.1IL8, CCL5
33extrinsic allergic alveolitis10.1CCL5, IL8
34chorioamnionitis10.1TNF, IL8
35rosacea10.1
36pyoderma gangrenosum10.1
37vitiligo10.1
38dermatomyositis10.1
39idiopathic pulmonary fibrosis10.1LAMC2, CCL5, IL8
40bronchiolitis10.1CCL5, IL8
41periodontal disease10.1TNF, LAMC2, IL8
42interstitial lung disease10.1CCL5, IL8
43endometriosis10.1IL8, ITGA6, CCL5
44pulmonary sarcoidosis10.1CCL5, TNF
45pulmonary disease, chronic obstructive10.0IL8, CCL5, TNF
46cork-handlers' disease10.0TNF, CCL5, IL8
47pneumonia10.0IL8, CCL5, TNF
48adult respiratory distress syndrome10.0IL8, TNF
49localized scleroderma10.0
50cutaneous lupus erythematosus10.0

Graphical network of the top 20 diseases related to Skin Disease:



Diseases related to skin disease

Symptoms for Skin Disease

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Drugs & Therapeutics for Skin Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Skin Disease

Drug clinical trials:

Search ClinicalTrials for Skin Disease

Search NIH Clinical Center for Skin Disease

Search CenterWatch for Skin Disease

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Skin Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Skin Disease:
JACE
Embryonic/Adult Cultured Cells Related to Skin Disease:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Skin Disease

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Anatomical Context for Skin Disease

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Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Skin Disease:

34
Skin, T cells, Testes, Eye, Bone, Kidney, Endothelial, Myeloid, B cells, Monocytes, Thyroid, Lung, Liver, Colon, Thymus, Bone marrow

FMA organs/tissues related to Skin Disease:

15
Skin

Animal Models for Skin Disease or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Skin Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9TNF, LAMC2, DST, ITGA6, IQGAP1
2MP:00107718.6CDSN, COL17A1, ITGA6, DST, LAMC2, TNF
3MP:00053878.5COL17A1, IL8, ITGA6, CCL5, LAMC2, CDSN
4MP:00107688.4GJB3, COL17A1, IQGAP1, ITGA6, DST, LAMC2

Publications for Skin Disease

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Sources:
53PubMed
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Articles related to Skin Disease:

(show top 50)    (show all 651)
idTitleAuthorsYear
1
Phase I study protocol for ex-vivo lentiviral gene therapy for the inherited skin disease, Netherton Syndrome. (24138501)
2013
2
IgG4-related skin disease successfully treated by thalidomide: a report of 2 cases with emphasis on pathological aspects. (23572226)
2013
3
Tungiasis - A Janus-faced parasitic skin disease. (24211240)
2013
4
Lumpy skin disease of cattle: an emerging problem in the Sultanate of Oman. (24097247)
2013
5
Analysis of high-dose intravenous immunoglobulin therapy in 16 patients with refractory autoimmune blistering skin disease: high efficacy and no serious adverse events. (23073990)
2013
6
Skin disease in individuals with liver and kidney transplants: influence of skin phototype and transplanted organ. (23895208)
2013
7
Genetic skin diseases predisposing to basal cell carcinoma. (22391625)
2012
8
Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. (22930385)
2012
9
Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. (22615377)
2012
10
Skin disease in dermatomyositis. (22907594)
2012
11
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (21839423)
2011
12
Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down. (22103940)
2011
13
Neutrophils require SHP1 to regulate IL-1I^ production and prevent inflammatory skin disease. (21160041)
2011
14
Usage of complementary and alternative medicine for management of skin disease. (21936703)
2011
15
Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases. (20636397)
2010
16
Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo. (20300524)
2010
17
Anakinra for difficult-to-treat neutrophilic panniculitis: IL-1 blockade as a promising treatment option for neutrophil-mediated inflammatory skin disease. (20197651)
2010
18
Dermatoses affecting desmosomes in animals: a mechanistic review of acantholytic blistering skin diseases. (20178467)
2009
19
Patients with skin disease and their relationships with their doctors: a qualitative study of patients with acne, psoriasis and eczema. (19236289)
2009
20
Is psoriasis a skin disease or a form of arthritis? (19768838)
2009
21
Connexin-26 mutations in deafness and skin disease. (19939300)
2009
22
Temporary tattoos to simulate skin disease: report and validation of a novel teaching tool. (19550194)
2009
23
Evaluation of the Cutaneous Lupus Activity and Severity Score in the assessment of lupus erythematosus skin disease. (17941937)
2008
24
Quantitative real-time RT-PCR measurement of cytokine mRNA expression in the skin of normal cats and cats with allergic skin disease. (18191230)
2008
25
Measurement of family impact of skin disease: further validation of the Family Dermatology Life Quality Index (FDLQI). (18312324)
2008
26
Meeting report of immunology and skin disease: new perspectives. (17632556)
2007
27
Therapy-resistent lupus skin disease successfully treated with rituximab. (16690759)
2006
28
Treating skin disease: self-management behaviors of Latino farmworkers. (17135140)
2006
29
Involving the patient: impact of inflammatory skin disease and patient-focused care. (15968267)
2005
30
Arthritis and skin disease. (16282751)
2005
31
The biology of Malassezia organisms and their ability to induce immune responses and skin disease. (15725101)
2005
32
The emotional impact of chronic and disabling skin disease: a psychoanalytic perspective. (16112437)
2005
33
Pimecrolimus for the treatment of inflammatory skin disease. (15013932)
2004
34
Defining the burden of skin disease in the United States--a historical perspective. (15083775)
2004
35
The allergy and immunology specialist: what is the role in the treatment of skin disease? (15576896)
2004
36
Prevalence of skin disease in HIV-positive pregnant women. (12839600)
2003
37
Use of a polymerase chain reaction assay to detect bovine herpesvirus type 2 DNA in skin lesions from cattle suspected to have pseudo-lumpy skin disease. (12762387)
2003
38
Etanercept ameliorates sarcoidosis arthritis and skin disease. (12913948)
2003
39
Implication of a healthcare worker with chronic skin disease in the transmission of an epidemic strain of methicillin-resistant Staphylococcus aureus in a pediatric intensive care unit. (12725361)
2003
40
Patients' and doctors' assessment of skin disease handicap. (12072021)
2002
41
Importance of thymidine kinase activity for normal growth of lumpy skin disease virus (SA-Neethling). (11958465)
2002
42
Lumpy skin disease in southern Africa: a review of the disease and aspects of control. (11513262)
2001
43
A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. (11590199)
2001
44
Questions answered and a $1 million question raised concerning lupus erythematosus tumidus: is routine laboratory surveillance testing during treatment with hydroxychloroquine for skin disease really necessary. (10926741)
2000
45
The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases. (10666397)
2000
46
Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. (10815854)
2000
47
Differential expression of CRABP II, psoriasin and cytokeratin 1 mRNA in human skin diseases. (8844119)
1996
48
Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases. (8763423)
1996
49
Development of interferon antibodies during the treatment of skin diseases with low-dose recombinant interferon alpha-2a]. (8597337)
1995
50
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990

Variations for Skin Disease

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Expression for genes affiliated with Skin Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Disease

Search GEO for disease gene expression data for Skin Disease.

Pathways for genes affiliated with Skin Disease

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 31KEGG, 56Reactome
See all sources

Pathways related to Skin Disease according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0COL17A1, ITGA6
29.9IL8, TNF
39.9IL8, TNF
4
Show member pathways
9.7TNF, ITGA6, LAMC2
5
Show member pathways
9.7GJB3, GJB4
69.7LAMC2, TNF, IL8
7
Show member pathways
9.6TNF, IL8, CCL5
89.6CCL5, IL8, TNF
99.6CCL5, TNF, IL8
10
Show member pathways
9.6LAMC2, DST, ITGA6, COL17A1
11
Show member pathways
9.6COL17A1, LAMC2, ITGA6, DST
12
Show member pathways
9.6DST, COL17A1, ITGA6, LAMC2
13
Show member pathways
9.4TNF, CCL5, ITGA6, IL8
14
Show member pathways
9.4IL8, ITGA6, CCL5, TNF
15
Show member pathways
9.4IL8, IQGAP1, TNF, CCL5
16
Show member pathways
9.3IQGAP1, LAMC2, DST, ITGA6, COL17A1
17
Show member pathways
9.3LAMC2, IL8, ITGA6, COL17A1, CCL5
18
Show member pathways
8.7TNF, LAMC2, CCL5, ITGA6, IL8, IQGAP1

Compounds for genes affiliated with Skin Disease

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Skin Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1ena 784610.4CCL5, IL8
2rebamipide4610.3CCL5, IL8
3loratadine46 25 1212.3IL8, CCL5
4cilomilast4610.3TNF, IL8
5mcp 14610.3CCL5, IL8
6n-tosyl-l-phenylalanine chloromethyl ketone4610.3TNF, IL8
7taurine chloramine4610.3TNF, IL8
8gabexate mesilate4610.3IL8, TNF
9ulinastatin4610.3IL8, TNF
10pranlukast46 30 1212.3CCL5, TNF
11toxin-14610.2IL8, TNF
12salmeterol46 52 30 1213.2IL8, CCL5
13kalinin4610.2LAMC2, ITGA6, DST
14gold sodium thiomalate4610.2TNF, IL8
15gold4610.1COL17A1, LAMC2, DST
16aebsf4610.1IL8, TNF
17mip 1alpha4610.1IL8, CCL5, TNF
18groalpha4610.1TNF, CCL5, IL8
19gm-csf46 3011.1TNF, CCL5, IL8
20triptolide4610.1IL8, CCL5, TNF
21budesonide46 52 1212.1CCL5, TNF, IL8
22fluticasone propionate46 52 62 1213.1TNF, IL8, CCL5
23poly(i-c)4610.1CCL5, TNF, IL8
24il 104610.1IL8, TNF, CCL5
25tarc4610.0IL8, TNF, CCL5
26peptidoglycan46 3011.0TNF, CCL5, IL8
27ccl346 3011.0TNF, CCL5, IL8
28pdtc4610.0IL8, CCL5, TNF
29leukotriene b446 62 2512.0CCL5, TNF, IL8
30sp 60012546 6211.0IL8, CCL5, TNF
315 aminosalicylic acid4610.0IL8, TNF
32scrambled 10panx6210.0GJB4, GJB3
33hydrocortisone46 3 62 1213.0TNF, CCL5, IL8
34carbenoxolone disodium6210.0GJB3, GJB4
35gap 276210.0GJB3, GJB4
36herbimycin a46 6211.0TNF, IL8, ITGA6
3710panx6210.0GJB4, GJB3
38egcg4610.0IL8, CCL5, TNF
39il-124610.0IL8, TNF
40simvastatin46 52 62 30 25 1214.9IL8, CCL5, TNF
41octanol30 2510.9GJB4, GJB3
42staurosporin469.9IL8, TNF
43endotoxin469.8TNF, IL8, CCL5
44pd 98,059469.8TNF, IL8, CCL5, ITGA6
45imiquimod46 62 30 1212.8TNF, IL8
46fmlp469.8IL8, TNF, CCL5
47nacl469.7COL17A1, CCL5, DST
48tpck469.6TNF, IL8
49cycloheximide469.6TNF, DST, CCL5, IL8, COL17A1
50serine469.2CDSN, TNF, CCL5, IL8, COL17A1, IQGAP1

GO Terms for genes affiliated with Skin Disease

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Sources:
17Gene Ontology
See all sources

Cellular components related to Skin Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal plasma membraneGO:00992510.0ITGA6, DST
2hemidesmosomeGO:0300569.9COL17A1, ITGA6, DST
3basement membraneGO:0056049.8COL17A1, ITGA6, DST
4cell leading edgeGO:0312529.7IQGAP1, DST
5connexon complexGO:0059229.6GJB3, GJB4
6extracellular regionGO:0055768.9TNF, LAMC2, CCL5, IL8, COL17A1, CDSN

Biological processes related to Skin Disease according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of G-protein coupled receptor protein signaling pathwayGO:04574410.1CCL5, IL8
2neutrophil activationGO:04211910.1IL8, CCL5
3positive regulation of phosphorylationGO:04232710.1ITGA6, CCL5
4cellular response to fibroblast growth factor stimulusGO:04434410.1CCL5, IL8
5embryonic digestive tract developmentGO:04856610.1IL8, TNF
6cell junction assemblyGO:03432910.1COL17A1, ITGA6, LAMC2
7epidermis developmentGO:00854410.0CDSN, COL17A1, LAMC2
8cellular response to organic cyclic compoundGO:0714079.9TNF, CCL5, ITGA6
9lipopolysaccharide-mediated signaling pathwayGO:0316639.9CCL5, TNF
10negative regulation of viral genome replicationGO:0450719.9CCL5, TNF
11hemidesmosome assemblyGO:0315819.9COL17A1, ITGA6, DST, LAMC2
12protein kinase B signalingGO:0434919.8CCL5, TNF
13cell communicationGO:0071549.8GJB4, GJB3
14cellular response to interleukin-1GO:0713479.6IL8, CCL5
15extracellular matrix organizationGO:0301989.5TNF, LAMC2, DST, ITGA6, COL17A1

Products for genes affiliated with Skin Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Skin Disease

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet