MCID: SKN016
MIFTS: 64

Skin Disease malady

Skin category

Summaries for Skin Disease

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 A cutaneous condition is any medical condition that affects the integumentary system — the organ... more...

MalaCards: Skin Disease, also known as dermatitis due to unspecified substance taken internally, is related to atopic dermatitis and pemphigus. An important gene associated with Skin Disease is LOR (loricrin), and among its related pathways are Cell-cell junction organization and Type I hemidesmosome assembly. The drugs menthol and prednisolone and the compounds serine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are immune system and integument.

Disease Ontology:8 An integumentary system disease that is located in skin.

Aliases & Classifications for Skin Disease

Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

skin disease 8 10 31
dermatitis due to unspecified substance taken internally 8
dermatitis due to substances taken internally 8
skin and subcutaneous tissue disease 8
dermatologic disorders 61
skin diseases, genetic 61
skin diseases genetic 45
genetic skin disease 8
genodermatosis, nos 8
genodermatosis 8
skin diseases 45


Related Diseases for Skin Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Skin Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 287)
idRelated DiseaseScoreTop Affiliating Genes
1atopic dermatitis30.5KLK7, LOR
2pemphigus30.3DSG3, DST, DSG1
3bullous pemphigoid30.2LAMC2, KRT14, COL17A1, CCL5, DSG3, DST
4onchocerciasis30.1IL5
5psoriatic arthritis30.1TNF
6keratoderma30.0TGM1, KRT14, DSG1, LOR
7pemphigus vulgaris30.0DSG3, DST, DSG1
8netherton syndrome29.9TGM1, CDSN, IGHE, DSG1, KLK7
9herpes gestationis29.9COL17A1, DST
10epidermolytic hyperkeratosis29.9TGM1, LOR
11urticaria29.9IGHE
12stevens-johnson syndrome29.9TGM1
13squamous cell carcinoma29.7COL17A1, DSG3, DST, DSG1, LELP1, KRT14
14ichthyosis vulgaris29.7TGM1, KRT14, LOR
15atopy29.7IL5, IGHE, CCL5
16pemphigus foliaceus29.7DSG1, DST, DSG3
17congenital ichthyosiform erythroderma29.7LOR, TGM1
18basal cell carcinoma29.7LAMC2, DST, COL17A1
19vohwinkel syndrome29.7LOR
20erythrokeratodermia variabilis29.6GJB3
21granulomatous slack skin disease10.3
22acne10.3
23arthritis10.3
24n syndrome10.2
25vesiculobullous skin disease10.2
26vitiligo10.1
27cutaneous lupus erythematosus10.1
28tungiasis10.1
29occupational dermatitis10.1
30vascular skin disease10.1
31lip disease10.1
32birt–hogg–dubé syndrome10.1
33degos 'en cocarde' erythrokeratoderma10.1
34birt-hogg-dub� syndrome10.1
35rosacea10.0
36hidradenitis suppurativa10.0
37pyoderma gangrenosum10.0
38mycosis fungoides10.0
39autosomal dominant disease10.0
40venous insufficiency10.0
41toxic epidermal necrolysis10.0
42psoriasis10.0LOR, KLK7, CCL5, TNF, DST, CDSN
43hypersensitivity reaction type ii disease10.0COL17A1, CCL5, TNF, DSG3, DST, DSG1
44bullous skin disease10.0COL17A1, CCL5, DSG3, DST, DSG1, IL5
45nonepidermolytic palmoplantar keratoderma10.0LOR, KLK7, DSG1, GJB3, KRT14, TGM1
46adenocarcinoma10.0KLK7, CCL5, DSG3, KRT14, LAMC2, TDGF1P3
47dermatitis10.0LOR, DSG3, DSG1, IGHE, IL5
48melanoma10.0TNF, DST, DSG1, IL8, KRT14, LAMC2
49lichen planus10.0COL17A1, DSG3, DST, LAMC2
50epidermolysis bullosa10.0COL17A1, DST, KRT14, LAMC2

Graphical network of the top 20 diseases related to Skin Disease:



Diseases related to skin disease

Clinical Features for Skin Disease

Drugs & Therapeutics for Skin Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Skin Disease

Drug clinical trials:

Search ClinicalTrials for Skin Disease

Search NIH Clinical Center for Skin Disease

Search CenterWatch for Skin Disease

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Skin Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Skin Disease:
JACE
Embryonic/Adult Cultured Cells Related to Skin Disease:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Skin Disease

Anatomical Context for Skin Disease

Sources:
14FMA
See all sources

FMA organs/tissues related to Skin Disease:

14
Skin

Animal Models for Skin Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Skin Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.5COL17A1, CCL5, TNF, DSG3, IGHE, CDSN
2MP:001077111.1TGM1, LOR, COL17A1, TNF, DSG3, DST

Publications for Skin Disease

Sources:
51PubMed
See all sources

Articles related to Skin Disease:

(show top 50)    (show all 1104)
idTitleAuthorsYear
1
Association Between Thiopurine Use and Nonmelanoma Skin Cancers in Patients With Inflammatory Bowel Disease: A Meta-Analysis. (24419479)
2014
2
Pemphigus Disease Activity Measurements: Pemphigus Disease Area Index, Autoimmune Bullous Skin Disorder Intensity Score, and Pemphigus Vulgaris Activity Score. (24429657)
2014
3
Clinicopathologic analysis of IgG4-related skin disease. (23174935)
2013
4
The involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis. (24069552)
2013
5
Serum concentration of IL-17, IL-23 and TNF-I+ among patients with chronic spontaneous urticaria: association with disease activity and autologous serum skin test. (23451767)
2013
6
Skin disease in dermatomyositis. (22907594)
2012
7
Correlation and agreement of self-assessed and objective skin disease severity in a cross-sectional study of patients with acne, psoriasis, and atopic eczema. (22097994)
2011
8
Autologous serum skin test response in chronic spontaneous urticaria and respiratory diseases and its relationship with serum interleukin-18 level. (21448661)
2011
9
The African Programme for Onchocerciasis Control: impact on onchocercal skin disease. (21481109)
2011
10
Managing skin disease in resource-poor environments - the role of community-oriented training and control programs. (21506972)
2011
11
Sebaceous hyperplasia: a pilot study to correlate this skin disease with circulating androgen levels. (22147031)
2011
12
Elafin is a biomarker of graft-versus-host disease of the skin. (20371463)
2010
13
A Potential Role for Ixodid (Hard) Tick Vectors in the Transmission of Lumpy Skin Disease Virus in Cattle. (21114790)
2010
14
Evaluation of different diagnostic methods for diagnosis of Lumpy skin disease in cows. (19882228)
2010
15
Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. (20445552)
2010
16
Drug treatments for skin disease introduced in 2009. (20361170)
2010
17
Is psoriasis a skin disease or a form of arthritis? (19768838)
2009
18
Allergic skin disease: major highlights and recent advances. (19932327)
2009
19
Prevalence of infiltrative lymphocytic mural folliculitis in equine inflammatory skin diseases. (20095233)
2009
20
Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease. (18830269)
2009
21
Advances in allergic skin disease: omalizumab is a promising therapy for urticaria and angioedema. (18774168)
2009
22
Out from under the skin: Disease etiology, biology and society: a commentary on Aronowitz. (18378055)
2008
23
Durometry for the assessment of skin disease in systemic sclerosis. (16874783)
2006
24
The costs of skin disease. (16935820)
2006
25
Arthritis and skin disease. (16282751)
2005
26
Hypoplastic thyroid, growth hormone deficiency, corneal opacities, cataract and hyperkeratotic skin disease: a possible new ichthyosis syndrome associated with endocrinopathies. (15875205)
2005
27
Occupational skin disease in Sweden--a 12-year follow-up. (16364116)
2005
28
Factors affecting prescription of ultra-high potency topical corticosteroids in skin disease: an analysis of US national practice data. (16302555)
2005
29
Topical tacrolimus 0.1% ointment for refractory skin disease in dermatomyositis: a pilot study. (14754648)
2004
30
Patient advocacy and patient perspective of skin disease. (15083773)
2004
31
Matrix metalloproteinase-19 expression in normal and diseased skin: dysregulation by epidermal proliferation. (14708597)
2003
32
Skin biopsy in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls. (14663053)
2003
33
The management of HIV-related skin disease. Part I: infections. (12662385)
2003
34
Patients' and doctors' assessment of skin disease handicap. (12072021)
2002
35
Functional studies of human skin disease- and deafness-associated connexin 30 mutations. (12419304)
2002
36
Onchocerciasis: the clinical and epidemiological burden of skin disease in Africa. (12061975)
2002
37
Oedematous skin disease of buffalo in Egypt. (15129580)
2001
38
Questions answered and a $1 million question raised concerning lupus erythematosus tumidus: is routine laboratory surveillance testing during treatment with hydroxychloroquine for skin disease really necessary. (10926741)
2000
39
The psychological impact of skin disease. (11963715)
2000
40
A 17-year-old adolescent with acneiform skin changes. Diagnosis: lipoid proteinosis (Urbach-Wiethe disease, Hyalinosis Cutis et Mucosae). (10486095)
1999
41
Sinus histiocytosis (Rosai-Dorfman disease) clinically limited to the skin. (10494712)
1999
42
Intraepidermal bile pigment in skin biopsy specimens for graft-versus-host disease versus erythema multiforme. (9796731)
1998
43
An increased ratio of interleukin-1 receptor antagonist to interleukin-1alpha in inflammatory skin diseases. (9858135)
1998
44
The expression of placental-type glutathione S-transferase (GST-pi) in human cutaneous carcinoma in situ, that is, actinic keratosis and Bowen's disease, compared with normal human skin. (7586130)
1995
45
A paraneoplastic mixed bullous skin disease associated with anti-skin antibodies and a B-cell lymphoma. (8323309)
1993
46
Expression of beta-2 integrin molecules on human keratinocytes in cytokine-mediated skin diseases. (1357849)
1992
47
The role of epidermal cytokines in inflammatory skin diseases. (16788625)
1990
48
Relationship between circulating anti-Ro/SS-A antibody levels and skin disease activity in subacute cutaneous lupus erythematosus. (3118930)
1987
49
Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer. A model for viral oncogenesis. (212144)
1978
50
Mucolipidosis II (I-cell disease): ultrastructural observations of conjunctiva and skin. (4255137)
1971

Genetic Variations for Skin Disease

Expression for genes affiliated with Skin Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Skin Disease

Search GEO for disease gene expression data for Skin Disease.

Pathways for genes affiliated with Skin Disease

Sources:
54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Skin Disease

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Skin Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1serine4512.0SERPINB13, LOR, KLK7, COL17A1, CCL5, TNF
2retinoic acid45 2412.8LOR, KLK7, CCL5, TNF, DSG1, IGHE
3calcium45 50 11 2414.7LOR, KLK7, COL17A1, CCL5, DSG3, DST
4cycloheximide4511.5COL17A1, CCL5, TNF, DST, IGHE, IL5
5hydrocortisone45 2 60 1114.4CCL5, TNF, IGHE, IL5, IL8, KRT14
6proline4511.4LOR, COL17A1, CCL5, GJB3, LELP1, KRT14
7budesonide45 50 1113.4CCL5, TNF, IGHE, IL5, IL8
8fluticasone propionate45 50 60 1114.4CCL5, TNF, IGHE, IL5, IL8
9tarc4511.4CCL5, TNF, IGHE, IL5, IL8
10vitamin a45 11 2413.3TGM1, KRT14, LELP1, IGHE, LOR
11vitamin d4511.3CCL5, IGHE, IL5, KRT14, TGM1
12poly(i-c)4511.3CCL5, TNF, IL5, IL8
13histamine45 29 2413.3CCL5, TNF, IGHE, IL5, IL8
14il 104511.3IL8, IL5, TNF, CCL5
15methacholine45 1112.3CCL5, IGHE, IL5, IL8
16leukotriene b445 60 2413.2CCL5, TNF, IL5, IL8
17ivig4511.2IGHE, DSG1, DSG3
18prednisolone45 29 1113.2IL5, IGHE, DSG3, TNF
19cyclosporin a45 29 6013.2CCL5, TNF, IGHE, IL5, IL8
20nedocromil sodium4511.2IL8, IL5, IGHE
21cetirizine45 29 11 2414.2IL8, IL5, IGHE
22loratadine45 11 2413.2CCL5, IGHE, IL8
23mcp 14511.2IL8, IL5, CCL5
24mip 1alpha4511.1CCL5, TNF, IL8
25pranlukast45 29 1113.1CCL5, TNF, IL5
26salmeterol45 50 29 1114.1CCL5, IL5, IL8
27calcipotriol45 60 29 1114.1TGM1, KRT14, IL8
28il-124511.1IL8, IL5, TNF
29imiquimod45 29 60 1114.1TNF, IL5, IL8
30montelukast45 50 29 1114.1IGHE, IL5, IL8
31fmlp4511.1CCL5, TNF, IL5, IL8
32gm-csf45 2912.1CCL5, TNF
33groalpha4511.1IL8, TNF, CCL5
34triptolide4511.1IL8, TNF, CCL5
35salbutamol45 50 29 11 2415.1IGHE, IL5, IL8
36polyinosinic-polycytidylic acid4511.0IL8, IL5, TNF
37methotrexate45 50 1113.0CCL5, TNF, IGHE, IL5
38josamycin45 1112.0IL5, IL8
39ena 784511.0CCL5, IL8
40collodion4510.9LOR, TGM1
41peptidoglycan45 2911.9CCL5, TNF, IL8
42n-formylmethionyl-leucylphenylalanine4510.9IL8, IL5, TNF
43omalizumab45 1111.9IL5, IGHE
44unicap4510.9IL5, IGHE
45ccl345 2911.9IL8, TNF, CCL5
46oxatomide4510.7IGHE, IL5
47rebamipide4510.7CCL5, IL8
48beclomethasone dipropionate4510.7IL5, IGHE
49epsilon-(gamma-glutamyl)lysine4510.6LOR, TGM1
50rantes4510.5IL8, IL5, TNF, CCL5

GO Terms for genes affiliated with Skin Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Skin Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4SERPINB13, KLK7, COL17A1, CCL5, TNF, IGHE
2cornified envelopeGO:00153310.7LOR, CDSN, TGM1
3cell-cell junctionGO:00591110.7CDSN, DSG1, COL17A1
4desmosomeGO:03005710.6CDSN, DSG1, DSG3
5hemidesmosomeGO:03005610.4DST, COL17A1

Biological processes related to Skin Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1epidermis developmentGO:00854411.1KLK7, COL17A1, CDSN, KRT14, LAMC2
2hemidesmosome assemblyGO:03158111.1LAMC2, KRT14, DST, COL17A1
3keratinocyte differentiationGO:03021610.9TGM1, CDSN, LOR
4inflammatory responseGO:00695410.8IL8, IL5, TNF, CCL5
5cell junction assemblyGO:03432910.8LAMC2, KRT14, COL17A1
6positive regulation of podosome assemblyGO:07180310.8IL5, TNF
7negative regulation of G-protein coupled receptor protein signaling pathwayGO:04574410.8CCL5, IL8
8extracellular matrix organizationGO:03019810.7COL17A1, TNF, DST, LAMC2
9neutrophil activationGO:04211910.7IL8, CCL5
10positive regulation of JAK-STAT cascadeGO:04642710.4IL5, CCL5

Products for genes affiliated with Skin Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Skin Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet