MCID: SKN016
MIFTS: 75

Skin Disease malady

Skin diseases category

Summaries for Skin Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A cutaneous condition is any medical condition that affects the integumentary system — the organ... more...

MalaCards: Skin Disease, also known as dermatitis due to unspecified substance taken internally, is related to psoriasis and bullous skin disease. An important gene associated with Skin Disease is LOR (loricrin), and among its related pathways are Cell-cell junction organization and Type I hemidesmosome assembly. The drugs prednisolone and prednisone and the compounds serine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and testes, and related mouse phenotypes are immune system and integument.

Disease Ontology:8 An integumentary system disease that is located in skin.

Aliases & Classifications for Skin Disease

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

skin disease 8 10 30
dermatitis due to unspecified substance taken internally 8
dermatitis due to substances taken internally 8
skin and subcutaneous tissue disease 8
dermatologic disorders 60
skin diseases, genetic 60
skin diseases genetic 44
genetic skin disease 8
genodermatosis, nos 8
genodermatosis 8
skin diseases 44


Related Diseases for Skin Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Skin Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 292)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.8LOR, KLK7, CCL5, TNF, DST, CDSN
2bullous skin disease30.6COL17A1, CCL5, DSG3, DST, DSG1, IL5
3dermatitis30.6LOR, DSG3, DSG1, IGHE, IL5
4atopic dermatitis30.4KLK7, LOR
5pemphigus30.3DSG3, DST, DSG1
6bullous pemphigoid30.2LAMC2, KRT14, COL17A1, CCL5, DSG3, DST
7contact dermatitis30.1IGHE, IL5
8onchocerciasis30.0IL5
9psoriatic arthritis30.0TNF
10netherton syndrome29.8TGM1, CDSN, IGHE, DSG1, KLK7
11eosinophilia29.8CCL5, IGHE, IL5, IL8
12herpes gestationis29.8COL17A1, DST
13epidermolytic hyperkeratosis29.8TGM1, LOR
14urticaria29.8IGHE
15stevens-johnson syndrome29.8TGM1
16squamous cell carcinoma29.6COL17A1, DSG3, DST, DSG1, LELP1, KRT14
17epidermolysis bullosa29.6COL17A1, DST, KRT14, LAMC2
18pemphigus vulgaris29.6DSG3, DST, DSG1
19ichthyosis vulgaris29.6TGM1, KRT14, LOR
20sarcoidosis29.6CCL5, TNF
21congenital ichthyosiform erythroderma29.6LOR, TGM1
22basal cell carcinoma29.6LAMC2, DST, COL17A1
23erythrokeratodermia variabilis29.6GJB3
24lupus erythematosus10.3
25acne10.2
26arthritis10.2
27bazex-dupre-christol syndrome10.2
28granulomatous slack skin disease10.1
29vitiligo10.1
30dermatomyositis10.1
31scleroderma10.1
32degos 'en cocarde' erythrokeratoderma10.1
33cutaneous lupus erythematosus10.0
34tungiasis10.0
35occupational dermatitis10.0
36collagen disease10.0
37irritant dermatitis10.0
38obesity10.0
39vascular skin disease10.0
40vesiculobullous skin disease10.0
41hypersensitivity reaction type ii disease10.0COL17A1, CCL5, TNF, DSG3, DST, DSG1
42nonepidermolytic palmoplantar keratoderma10.0LOR, KLK7, DSG1, GJB3, KRT14, TGM1
43adenocarcinoma10.0KLK7, CCL5, DSG3, KRT14, LAMC2, TDGF1P3
44melanoma10.0TNF, DST, DSG1, IL8, KRT14, LAMC2
45lichen planus10.0COL17A1, DSG3, DST, LAMC2
46epidermolysis bullosa acquisita10.0COL17A1, DST, DSG1, LAMC2
47keratoderma10.0TGM1, KRT14, DSG1, LOR
48bronchiolitis10.0IL8, IL5, IGHE, CCL5
49vernal keratoconjunctivitis10.0IL8, IL5, IGHE, CCL5
50allergic asthma10.0CCL5, IGHE, IL5, IL8

Graphical network of the top 20 diseases related to Skin Disease:



Diseases related to skin disease

Clinical Features for Skin Disease

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Drugs & Therapeutics for Skin Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Skin Disease

Drug clinical trials:

Search ClinicalTrials for Skin Disease

Search NIH Clinical Center for Skin Disease

Search CenterWatch for Skin Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Skin Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Skin Disease:
JACE
Embryonic/Adult Cultured Cells Related to Skin Disease:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Skin Disease

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Anatomical Context for Skin Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Skin Disease:

32
Skin, Testes, T cells, Kidney, Liver, Bone, Eye, Lung, Brain, Endothelial, Heart, Bone marrow, Thyroid, B cells, Colon, Myeloid, Tonsil, Monocytes, Nk cells, Breast, Tongue, Skeletal muscle, Smooth muscle, Cortex, Thymus, Lymph node

FMA organs/tissues related to Skin Disease:

14
Skin

Animal Models for Skin Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Skin Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.5COL17A1, CCL5, TNF, DSG3, IGHE, CDSN
2MP:001077111.1TGM1, LOR, COL17A1, TNF, DSG3, DST

Publications for Skin Disease

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Sources:
50PubMed
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Articles related to Skin Disease:

(show top 50)    (show all 1099)
idTitleAuthorsYear
1
Avoiding rash decision making: skin cancer screening of patients with inflammatory bowel disease. (24183955)
2014
2
CXCR3 Mediated Skin Homing of Autoreactive CD8 T Cells is a Key Determinant in Murine Graft-Versus-Host Disease. (24390137)
2014
3
Dermatitis herpetiformis, the celiac disease of the skin! (24322197)
2013
4
The three dimensions of skin disease burden: 'now', 'long term' and 'family'. (24175672)
2013
5
Oxidative stress and autoimmune skin disease. (23420016)
2013
6
Interferon and biologic signatures in dermatomyositis skin: specificity and heterogeneity across diseases. (22235269)
2012
7
Hematogenously disseminated skin disease caused by Mucor velutinosus in a patient with acute myeloid leukemia. (21543575)
2011
8
Myofibroblasts generated in culture from sclerotic skin lesions of a patient with extensive chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation are of recipient origin. (20001597)
2010
9
IKKbeta leads to an inflammatory skin disease resembling interface dermatitis. (20200541)
2010
10
Skin wounds associated with calciphylaxis in end-stage renal disease patients on dialysis. (20692603)
2010
11
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. (20130594)
2010
12
Rhizopus oryzae skin infection treated with posaconazole in a boy with chronic granulomatous disease. (20508483)
2010
13
Pain associated with aminolevulinic acid-photodynamic therapy of skin disease. (19925929)
2009
14
Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin. (19168032)
2009
15
Dermatology and skin disease in the American Civil War. (18380293)
2008
16
Urticaria and urticaria related skin condition/disease in children. (18700329)
2008
17
Skin diseases associated with Malassezia species in humans. Clinical features and diagnostic criteria. (18693561)
2008
18
Comparison of interferon-gamma release assay versus tuberculin skin test for tuberculosis screening in inflammatory bowel disease. (18684188)
2008
19
Tertiary individual prevention of occupational skin diseases: a decade's experience with recalcitrant occupational dermatitis. (18239930)
2008
20
Meeting report of immunology and skin disease: new perspectives. (17632556)
2007
21
Adult glycogenosis type II (Pompe's disease): morphological abnormalities in muscle and skin biopsies compared with acid alpha-glucosidase activity. (18176891)
2007
22
Sympathetic skin response in patients with peripheral arterial occlusive disease. (16414001)
2006
23
Degos' disease: acute abdomen with skin rash. (16974032)
2006
24
Analysis of the role of CovR and CovS in the dissemination of Streptococcus pyogenes in invasive skin disease. (16542816)
2006
25
Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases. (16086736)
2005
26
Early secondary prevention of occupational skin disease in Germany: the dermatologist's procedure in perspective. (14618333)
2004
27
Demodex folliculitis: a skin manifestation of immune reconstitution disease. (15090780)
2004
28
Prevalence of skin disease in HIV-positive pregnant women. (12839600)
2003
29
Development of spliceosome-mediated RNA trans-splicing (SMaRT) for the correction of inherited skin diseases. (12631245)
2003
30
The importance of skin disease as assessed by "willingness-to-pay". (14505193)
2003
31
Abundance of interstitial heparan sulfate in granuloma annulare but not in other mucinous skin diseases. (12358809)
2002
32
Skin disease: a very visible problem. (12238726)
2002
33
Defective trafficking and cell death is characteristic of skin disease-associated connexin 31 mutations. (12165562)
2002
34
Atopic dermatitis: a paradigmatic allergic skin disease. (11817663)
2001
35
Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease. (11350846)
2001
36
Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma. (11313759)
2001
37
Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate. (11555673)
2001
38
Genotype-phenotype relationship of Niemann-Pick disease type C: a possible correlation between clinical onset and levels of NPC1 protein in isolated skin fibroblasts. (11182931)
2000
39
Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma. (11038186)
2000
40
Dermatitis herpetiformis: coeliac disease of the skin. (9814827)
1998
41
Loricrin and human skin diseases: molecular basis of loricrin keratodermas. (9690138)
1998
42
Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique. (9008232)
1997
43
Simultaneous measurement of digital artery and skin perfusion pressure by the laser Doppler technique in healthy controls and patients with peripheral arterial occlusive disease. (7655978)
1995
44
In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease. (7507681)
1993
45
Herpes gestationis: ultrastructural identification of the extracellular antigenic sites in diseased skin using immunogold techniques. (1954119)
1991
46
Lafora disease diagnosed by skin biopsy. (3939310)
1985
47
The association of transient acantholytic dermatosis with other skin diseases. (6237126)
1984
48
Nosocomial scalded skin syndrome. Ritter's disease caused by phage group 3 Staphylococcus aureus. (6449146)
1980
49
Ultrastructure of lipid bodies and lysosomes in the skin in Fabry's disease (angiokeratoma corporis diffusum). (4348059)
1972
50
An examination of skin from patients with collagen disease utilizing the combined Alcian blue-periodic acid Schiff stain. (13406286)
1956

Genetic Variations for Skin Disease

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Expression for genes affiliated with Skin Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Disease

Search GEO for disease gene expression data for Skin Disease.

Pathways for genes affiliated with Skin Disease

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Skin Disease

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Skin Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1serine4412.0IL8, CCL5, TNF, DSG3, KLK7, DSG1
2retinoic acid44 2412.8TNF, TGM1, IGHE, KLK7, CCL5, DSG1
3calcium44 49 11 2414.7KRT14, TGM1, LELP1, DST, COL17A1, DSG3
4cycloheximide4411.5IGHE, COL17A1, CCL5, TNF, DST, IL5
5hydrocortisone44 2 59 1114.4TNF, CCL5, KRT14, IL8, IGHE, IL5
6proline4411.4LELP1, GJB3, CCL5, LOR, COL17A1, KRT14
7budesonide44 49 1113.4TNF, IGHE, IL5, IL8, CCL5
8fluticasone propionate44 49 59 1114.4TNF, CCL5, IL8, IL5, IGHE
9tarc4411.4IL8, IL5, IGHE, TNF, CCL5
10vitamin a44 11 2413.3LELP1, LOR, TGM1, IGHE, KRT14
11vitamin d4411.3TGM1, CCL5, KRT14, IGHE, IL5
12poly(i-c)4411.3CCL5, TNF, IL5, IL8
13histamine44 28 2413.3IL5, CCL5, TNF, IGHE, IL8
14il 104411.3IL8, TNF, CCL5, IL5
15methacholine44 1112.3IL5, IL8, IGHE, CCL5
16leukotriene b444 59 2413.2TNF, IL8, IL5, CCL5
17ivig4411.2IGHE, DSG1, DSG3
18prednisolone44 28 1113.2IGHE, IL5, TNF, DSG3
19cyclosporin a44 28 5913.2IGHE, IL5, TNF, CCL5, IL8
20cetirizine44 28 11 2414.2IL8, IGHE, IL5
21nedocromil sodium4411.2IL5, IGHE, IL8
22loratadine44 11 2413.2IL8, IGHE, CCL5
23mcp 14411.2IL8, IL5, CCL5
24pranlukast44 28 1113.1CCL5, IL5, TNF
25mip 1alpha4411.1IL8, TNF, CCL5
26salmeterol44 49 28 1114.1IL5, IL8, CCL5
27calcipotriol44 59 28 1114.1IL8, KRT14, TGM1
28il-124411.1TNF, IL5, IL8
29montelukast44 49 28 1114.1IGHE, IL5, IL8
30imiquimod44 28 59 1114.1IL5, IL8, TNF
31fmlp4411.1CCL5, IL5, TNF, IL8
32gm-csf44 2812.1TNF, CCL5
33groalpha4411.1IL8, CCL5, TNF
34triptolide4411.1CCL5, TNF, IL8
35salbutamol44 49 28 11 2415.1IGHE, IL5, IL8
36polyinosinic-polycytidylic acid4411.0IL5, IL8, TNF
37methotrexate44 49 1113.0TNF, CCL5, IGHE, IL5
38collodion4411.0TGM1, LOR
39josamycin44 1112.0IL8, IL5
40ena 784410.9IL8, CCL5
41peptidoglycan44 2811.9CCL5, TNF, IL8
42n-formylmethionyl-leucylphenylalanine4410.9IL5, TNF, IL8
43unicap4410.9IGHE, IL5
44omalizumab44 1111.9IL5, IGHE
45ccl344 2811.9IL8, CCL5, TNF
46rebamipide4410.7CCL5, IL8
47oxatomide4410.7IGHE, IL5
48beclomethasone dipropionate4410.7IGHE, IL5
49epsilon-(gamma-glutamyl)lysine4410.6TGM1, LOR
50rantes4410.5IL8, IL5, TNF, CCL5

GO Terms for genes affiliated with Skin Disease

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Sources:
16Gene Ontology
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Cellular components related to Skin Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4SERPINB13, KLK7, COL17A1, CCL5, TNF, IGHE
2cornified envelopeGO:00153310.7LOR, CDSN, TGM1
3cell-cell junctionGO:00591110.7CDSN, DSG1, COL17A1
4desmosomeGO:03005710.6CDSN, DSG1, DSG3
5hemidesmosomeGO:03005610.4DST, COL17A1

Biological processes related to Skin Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1epidermis developmentGO:00854411.1KLK7, COL17A1, CDSN, KRT14, LAMC2
2hemidesmosome assemblyGO:03158111.1LAMC2, KRT14, DST, COL17A1
3keratinocyte differentiationGO:03021610.9TGM1, CDSN, LOR
4inflammatory responseGO:00695410.8IL8, IL5, TNF, CCL5
5cell junction assemblyGO:03432910.8LAMC2, KRT14, COL17A1
6positive regulation of podosome assemblyGO:07180310.8IL5, TNF
7negative regulation of G-protein coupled receptor protein signaling pathwayGO:04574410.8CCL5, IL8
8extracellular matrix organizationGO:03019810.7COL17A1, TNF, DST, LAMC2
9neutrophil activationGO:04211910.7IL8, CCL5
10positive regulation of JAK-STAT cascadeGO:04642710.4IL5, CCL5

Products for genes affiliated with Skin Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Skin Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet