MCID: SKN016
MIFTS: 75

Skin Disease malady

Skin diseases category

Summaries for Skin Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A cutaneous condition is any medical condition that affects the integumentary system — the organ... more...

MalaCards: Skin Disease, also known as dermatitis due to unspecified substance taken internally, is related to psoriasis and bullous skin disease. An important gene associated with Skin Disease is LOR (loricrin), and among its related pathways are Cell-cell junction organization and Type I hemidesmosome assembly. The drugs menthol and prednisolone and the compounds serine and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and testes, and related mouse phenotypes are immune system and integument.

Disease Ontology:8 An integumentary system disease that is located in skin.

Aliases & Classifications for Skin Disease

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8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

skin disease 8 10 30
dermatitis due to unspecified substance taken internally 8
dermatitis due to substances taken internally 8
skin and subcutaneous tissue disease 8
dermatologic disorders 60
skin diseases, genetic 60
skin diseases genetic 44
genetic skin disease 8
genodermatosis, nos 8
genodermatosis 8
skin diseases 44


Related Diseases for Skin Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Skin Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 292)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.8LOR, KLK7, CCL5, TNF, DST, CDSN
2bullous skin disease30.6COL17A1, CCL5, DSG3, DST, DSG1, IL5
3dermatitis30.6LOR, DSG3, DSG1, IGHE, IL5
4atopic dermatitis30.4KLK7, LOR
5pemphigus30.3DSG3, DST, DSG1
6bullous pemphigoid30.2LAMC2, KRT14, COL17A1, CCL5, DSG3, DST
7contact dermatitis30.1IGHE, IL5
8onchocerciasis30.0IL5
9psoriatic arthritis30.0TNF
10netherton syndrome29.8TGM1, CDSN, IGHE, DSG1, KLK7
11eosinophilia29.8CCL5, IGHE, IL5, IL8
12herpes gestationis29.8COL17A1, DST
13epidermolytic hyperkeratosis29.8TGM1, LOR
14urticaria29.8IGHE
15stevens-johnson syndrome29.8TGM1
16squamous cell carcinoma29.6COL17A1, DSG3, DST, DSG1, LELP1, KRT14
17epidermolysis bullosa29.6COL17A1, DST, KRT14, LAMC2
18pemphigus vulgaris29.6DSG3, DST, DSG1
19ichthyosis vulgaris29.6TGM1, KRT14, LOR
20sarcoidosis29.6CCL5, TNF
21congenital ichthyosiform erythroderma29.6LOR, TGM1
22basal cell carcinoma29.6LAMC2, DST, COL17A1
23erythrokeratodermia variabilis29.6GJB3
24lupus erythematosus10.3
25acne10.2
26arthritis10.2
27bazex-dupre-christol syndrome10.2
28granulomatous slack skin disease10.1
29vitiligo10.1
30dermatomyositis10.1
31scleroderma10.1
32degos 'en cocarde' erythrokeratoderma10.1
33cutaneous lupus erythematosus10.0
34tungiasis10.0
35occupational dermatitis10.0
36collagen disease10.0
37irritant dermatitis10.0
38obesity10.0
39vascular skin disease10.0
40vesiculobullous skin disease10.0
41hypersensitivity reaction type ii disease10.0COL17A1, CCL5, TNF, DSG3, DST, DSG1
42nonepidermolytic palmoplantar keratoderma10.0LOR, KLK7, DSG1, GJB3, KRT14, TGM1
43adenocarcinoma10.0KLK7, CCL5, DSG3, KRT14, LAMC2, TDGF1P3
44melanoma10.0TNF, DST, DSG1, IL8, KRT14, LAMC2
45lichen planus10.0COL17A1, DSG3, DST, LAMC2
46epidermolysis bullosa acquisita10.0COL17A1, DST, DSG1, LAMC2
47keratoderma10.0TGM1, KRT14, DSG1, LOR
48bronchiolitis10.0IL8, IL5, IGHE, CCL5
49vernal keratoconjunctivitis10.0IL8, IL5, IGHE, CCL5
50allergic asthma10.0CCL5, IGHE, IL5, IL8

Graphical network of the top 20 diseases related to Skin Disease:



Diseases related to skin disease

Clinical Features for Skin Disease

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Drugs & Therapeutics for Skin Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Skin Disease

Drug clinical trials:

Search ClinicalTrials for Skin Disease

Search NIH Clinical Center for Skin Disease

Search CenterWatch for Skin Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Skin Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Skin Disease:
JACE
Embryonic/Adult Cultured Cells Related to Skin Disease:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Skin Disease

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Anatomical Context for Skin Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Skin Disease:

32
Skin, Testes, T cells, Kidney, Bone, Liver, Lung, Eye, Endothelial, Heart, Brain, Bone marrow, Thyroid, Colon, B cells, Lymph node, Nk cells, Tonsil, Smooth muscle, Tongue, Monocytes, Myeloid, Breast, Skeletal muscle, Thymus, Cortex

FMA organs/tissues related to Skin Disease:

14
Skin

Animal Models for Skin Disease or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Skin Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.5LOR, COL17A1, KRT14, IL8, IL5, CDSN
2MP:001077111.1LOR, LAMC2, KRT14, GJB3, CDSN, DST

Publications for Skin Disease

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Sources:
50PubMed
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Articles related to Skin Disease:

(show top 50)    (show all 1099)
idTitleAuthorsYear
1
Evidence of lumpy skin disease virus over-wintering by transstadial persistence in Amblyomma hebraeum and transovarial persistence in Rhipicephalus decoloratus ticks. (23975563)
2014
2
Skin microbiota: overview and role in the skin diseases acne vulgaris and rosacea. (23374126)
2013
3
Febrile ulceronecrotic mucha habermann disease: case report of a dark-skinned patient. (23466681)
2013
4
Patient assessments of skin, joint, and nail disease activity in psoriatic arthritis. (22383354)
2012
5
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (21839423)
2011
6
Photodynamic therapy: mechanism of action and role in the treatment of skin disease. (20823792)
2010
7
Leukemia cutis is an early sign of blast transformation that may mimic a common skin disease: sycosis-like eruptions in chronic myelomonocytic leukemia. (20860746)
2010
8
The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. (19608284)
2009
9
Peri-urban aquatic plant culture and skin disease in Phnom Penh, Cambodia. (19240356)
2009
10
Comparison of interferon-gamma release assay versus tuberculin skin test for tuberculosis screening in inflammatory bowel disease. (19233329)
2009
11
An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice. (18443190)
2008
12
Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. (17601706)
2008
13
The use of C3d and C4d immunohistochemistry on formalin-fixed tissue as a diagnostic adjunct in the assessment of inflammatory skin disease. (19119098)
2008
14
Pyoderma gangrenosum of the penis: a potentially dramatic skin disease. (18314174)
2008
15
Images in neuro-oncology: a case of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes) in a patient with multicentric Castleman's disease. (17086436)
2007
16
The incidence of occupational skin disease as reported to The Health and Occupation Reporting (THOR) network between 2002 and 2005. (17596159)
2007
17
Cytochemical analysis of storage materials in cultured skin fibroblasts from patients with I-cell disease. (17204262)
2007
18
Effectiveness of the nursing programme 'Coping with itch': a randomized controlled study in adults with chronic pruritic skin disease. (17535222)
2007
19
Adult-onset Still's disease with prurigo pigmentosa-like skin eruption. (16469087)
2006
20
Acute graft-versus-host disease after liver transplantation diagnosed by fluorescent in situ hybridization testing of skin biopsy specimens. (17010745)
2006
21
Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis. (17075814)
2006
22
Sarcoma arising in hyaline-vascular castleman disease of skin and subcutis. (16121055)
2005
23
Management of "refractory" skin disease in patients with lupus erythematosus. (16150402)
2005
24
Calcineurin inhibitors for the treatment of skin disease: how do they work? (15898972)
2005
25
Correlation of acid alpha-glucosidase and glycogen content in skin fibroblasts with age of onset in Pompe disease. (15993875)
2005
26
Cyclin A and beta-catenin expression in actinic keratosis, Bowen's disease and invasive squamous cell carcinoma of the skin. (16307653)
2005
27
Defining the burden of skin disease in the United States--a historical perspective. (15083775)
2004
28
Impact of atopic skin diathesis on occupational skin disease incidence in a working population. (12839561)
2003
29
Antioxidant activity, lipid peroxidation and skin diseases. What's new. (14761133)
2003
30
Initial spontaneous remission of posttransplantation Epstein Barr virus-related B-cell lymphoproliferative disorder of the skin in a renal transplant recipient: case report and review of the literature on cutaneous B-cell posttransplantation lymphoproliferative disease. (12357204)
2002
31
Allergic diseases, skin prick test responses, and IgE levels in North Karelia, Finland, and the Republic of Karelia, Russia. (11941314)
2002
32
Bullous skin disease: an unusual allergic reaction to vancomycin. (12018672)
2002
33
A novel anti-inflammatory drug, SDZ ASM 981, for the treatment of skin diseases: in vitro pharmacology. (10468798)
1999
34
Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan. (10362120)
1999
35
Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin. (9502789)
1998
36
A case of primary hypertrophic osteoarthropathy without skin involvement (Currarino's disease). (9809365)
1998
37
IL-7 overexpression in transgenic mouse keratinocytes causes a lymphoproliferative skin disease dominated by intermediate TCR cells: evidence for a hierarchy in IL-7 responsiveness among cutaneous T cells. (9300730)
1997
38
Development of interferon antibodies during the treatment of skin diseases with low-dose recombinant interferon alpha-2a]. (8597337)
1995
39
Finasteride inhibits 5 alpha-reductase activity in human dermal fibroblasts: prediction of its therapeutic application in androgen-related skin diseases. (8537164)
1995
40
Multiple scattered granulomatous skin lesions in cat scratch disease. (1521488)
1992
41
Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease. (1401088)
1992
42
Picture of the month. Ritter's disease (neonatal staphylococcal scalded skin syndrome). (1558075)
1992
43
Immunopathological study of proliferation-associated antigens in proliferative skin diseases]. (2197470)
1990
44
Diagnosis of metachromatic leukodystrophy, Krabbe disease, and Farber disease after uptake of fatty acid-labeled cerebroside sulfate into cultured skin fibroblasts. (6806321)
1982
45
Paget's disease of the penis and adjacent skin: its association with fatal sweat gland carcinoma. (6269515)
1981
46
Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease? (626922)
1978
47
Hyperkeratosis lenticularis perstans (Flegel). An autosomal dominant skin disease due to lack of a keratinocytic organelle. (4430495)
1974
48
Evidence for complement activation via the alternate pathway in skin diseases, I. Herpes gestationis, systemic lupus erythematosus, and bullous pemphigoid. (4352464)
1973
49
THE METABOLISM OF LEUCINE IN TISSUE CULTURE OF SKIN FIBROBLASTS OF MAPLE-SYRUP-URINE DISEASE. (14089436)
1963
50
Comments to "The etiology of poral closure, an experimental study of miliaria rubra, bullous impetigo and related diseases of the skin. By John P. O'Brien, M. D.". (15437055)
1950

Genetic Variations for Skin Disease

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Expression for genes affiliated with Skin Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Skin Disease

Search GEO for disease gene expression data for Skin Disease.

Pathways for genes affiliated with Skin Disease

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Skin Disease

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Sources:
44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Skin Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1serine4412.0SERPINB13, LOR, KLK7, COL17A1, CCL5, TNF
2retinoic acid44 2412.8LOR, KLK7, CCL5, TNF, DSG1, IGHE
3calcium44 49 11 2414.7LOR, KLK7, COL17A1, CCL5, DSG3, DST
4cycloheximide4411.5COL17A1, CCL5, TNF, DST, IGHE, IL5
5hydrocortisone44 2 59 1114.4CCL5, TNF, IGHE, IL5, IL8, KRT14
6proline4411.4LOR, COL17A1, CCL5, GJB3, LELP1, KRT14
7budesonide44 49 1113.4CCL5, TNF, IGHE, IL5, IL8
8fluticasone propionate44 49 59 1114.4CCL5, TNF, IGHE, IL5, IL8
9tarc4411.4CCL5, TNF, IGHE, IL5, IL8
10vitamin a44 11 2413.3TGM1, KRT14, LELP1, IGHE, LOR
11vitamin d4411.3CCL5, IGHE, IL5, KRT14, TGM1
12poly(i-c)4411.3CCL5, TNF, IL5, IL8
13histamine44 28 2413.3CCL5, TNF, IGHE, IL5, IL8
14il 104411.3IL8, IL5, TNF, CCL5
15methacholine44 1112.3CCL5, IGHE, IL5, IL8
16leukotriene b444 59 2413.2CCL5, TNF, IL5, IL8
17ivig4411.2IGHE, DSG1, DSG3
18prednisolone44 28 1113.2IL5, IGHE, DSG3, TNF
19cyclosporin a44 28 5913.2CCL5, TNF, IGHE, IL5, IL8
20nedocromil sodium4411.2IL8, IL5, IGHE
21cetirizine44 28 11 2414.2IL8, IL5, IGHE
22loratadine44 11 2413.2CCL5, IGHE, IL8
23mcp 14411.2IL8, IL5, CCL5
24mip 1alpha4411.1CCL5, TNF, IL8
25pranlukast44 28 1113.1CCL5, TNF, IL5
26salmeterol44 49 28 1114.1CCL5, IL5, IL8
27calcipotriol44 59 28 1114.1TGM1, KRT14, IL8
28il-124411.1IL8, IL5, TNF
29imiquimod44 28 59 1114.1TNF, IL5, IL8
30montelukast44 49 28 1114.1IGHE, IL5, IL8
31fmlp4411.1CCL5, TNF, IL5, IL8
32gm-csf44 2812.1CCL5, TNF
33groalpha4411.1IL8, TNF, CCL5
34triptolide4411.1IL8, TNF, CCL5
35salbutamol44 49 28 11 2415.1IGHE, IL5, IL8
36polyinosinic-polycytidylic acid4411.0IL8, IL5, TNF
37methotrexate44 49 1113.0CCL5, TNF, IGHE, IL5
38josamycin44 1112.0IL5, IL8
39ena 784411.0CCL5, IL8
40collodion4410.9LOR, TGM1
41peptidoglycan44 2811.9CCL5, TNF, IL8
42n-formylmethionyl-leucylphenylalanine4410.9IL8, IL5, TNF
43omalizumab44 1111.9IL5, IGHE
44unicap4410.9IL5, IGHE
45ccl344 2811.9IL8, TNF, CCL5
46oxatomide4410.7IGHE, IL5
47rebamipide4410.7CCL5, IL8
48beclomethasone dipropionate4410.7IL5, IGHE
49epsilon-(gamma-glutamyl)lysine4410.6LOR, TGM1
50rantes4410.5IL8, IL5, TNF, CCL5

GO Terms for genes affiliated with Skin Disease

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Sources:
16Gene Ontology
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Cellular components related to Skin Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4SERPINB13, KLK7, COL17A1, CCL5, TNF, IGHE
2cornified envelopeGO:00153310.7LOR, CDSN, TGM1
3cell-cell junctionGO:00591110.7CDSN, DSG1, COL17A1
4desmosomeGO:03005710.6CDSN, DSG1, DSG3
5hemidesmosomeGO:03005610.4DST, COL17A1

Biological processes related to Skin Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1epidermis developmentGO:00854411.1KLK7, COL17A1, CDSN, KRT14, LAMC2
2hemidesmosome assemblyGO:03158111.1LAMC2, KRT14, DST, COL17A1
3keratinocyte differentiationGO:03021610.9TGM1, CDSN, LOR
4inflammatory responseGO:00695410.8IL8, IL5, TNF, CCL5
5cell junction assemblyGO:03432910.8LAMC2, KRT14, COL17A1
6positive regulation of podosome assemblyGO:07180310.8IL5, TNF
7negative regulation of G-protein coupled receptor protein signaling pathwayGO:04574410.8CCL5, IL8
8extracellular matrix organizationGO:03019810.7COL17A1, TNF, DST, LAMC2
9neutrophil activationGO:04211910.7IL8, CCL5
10positive regulation of JAK-STAT cascadeGO:04642710.4IL5, CCL5

Products for genes affiliated with Skin Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Skin Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet