Skin Disease malady

Wikipedia: A cutaneous condition is any medical condition that affects the integumentary system — the organ...⁴⁴ more...

MalaCards: Skin Disease, also known as genetic skin disease, is related to contact dermatitis and dermatitis herpetiformis. An important gene associated with Skin Disease is LOR (loricrin), and among its related pathways are Transendothelial Migration of Leukocytes and IL-6 Pathway. The drugs botulinum toxin type a and alclometasone dipropionate and the compounds fatty acid and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and thymus, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Disease Ontology: An integumentary system disease that is located in skin.⁶

Aliases & Descriptions:

skin disease 6 8 genetic skin disease 6 8 dermatitis due to unspecified substance taken internally (disorder) 6 dermatitis due to unspecified substance taken internally 6 dermatitis due to substances taken internally (disorder) 6 dermatitis due to substances taken internally 6 skin and subcutaneous tissue disease 6

genodermatosis (disorder) 6 skin diseases, genetic 43 dermatologic disorders 43 skin diseases genetic 32 genodermatosis, nos 6 skin diseases 32 dermatitis 43

Diseases related to skin disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1030)

id	Related Disease	Score	Top Affiliating Genes
1	contact dermatitis	37.7	FLG, IL1A, IL5, CCR4, IGHE, KRT16
2	dermatitis herpetiformis	36.6	SELE, CD79A, IL13, IL2RA, IL5, CCL11
3	eczema	36.1	SELE, VIP, MPO, CD79A, MMP1, FLG
4	asthma	34.6	IL13, IL18R1, IL4, IL5, IGHE, RNASE3
5	bullous skin disease	33.6	IL5, CCL5, EVPL, COL17A1, DSG1, DSG3
6	bullous pemphigoid	33.3	SERPINF2, CIITA, LAD1, LAMA3, LAMB3, LAMC2
7	eczema herpeticum	33.2	CDSN, FLG, IGHE, CAMP, DSC1, TGM3
8	keratoderma	33.0	LELP1, JUP, FLG, LOR, ALOX12B, EVPL
9	ichthyosis	32.1	LELP1, IVL, FLG, ARSH, LOR, ALOX12B
10	allergic contact dermatitis of eyelid	32.1	SELE, FLG, IL17A, IL5, CCL27, CCR4
11	atopic dermatitis	31.3	PDE4A, SELE, SELL, SELP, VIP, VCAM1
12	epidermolytic hyperkeratosis	31.1	LELP1, IVL, FLG, LOR, SPRR1B, KRT5
13	arthritis	30.0	SELL, VIP, IL17A, IL1A, IL1B, IL6
14	hyper-ige syndrome	29.8	SELL, MMP9, IL10, IL13, IL17A, IL4
15	skin conditions	29.6	ATP2C1, IL1A, IL6, IGHE, TNF, KRT10
16	allergic asthma	29.6	PDE4A, SFTPD, SELE, SELL, VCAM1, BDNF
17	immunodeficiency	29.5	SELL, VIP, CIITA, CD28, CD79A, CD4
18	acne	29.5	BTD, S100A7, ATP2A2, MPO, MMP1, MMP9
19	pyoderma gangrenosum	29.4	SERPINB13, ITGB2, MMP1, MMP26, IL6, IL8
20	squamous cell carcinoma	29.4	PI3, VTN, PCNA, SELL, SERPINB13, MYC
21	folliculitis	29.4	SERPINB13, IL2RA, IL4, IL5, CCL11, CCL5
22	ichthyosis vulgaris	29.3	CDSN, IVL, FLG, LOR, SPRR1B, SPRR3
23	psoriasis	29.3	PI3, PDE4A, VTN, SFTPD, PCNA, SELE
24	onchocerciasis	29.0	S100A8, IL10, IL13, IL4, IL5, CCL27
25	netherton syndrome	28.9	PI3, CDSN, FLG, IGHE, SPINK5, KLK6
26	congenital ichthyosiform erythroderma	28.9	IVL, FLG, ALOX12B, SPINK5, KRT10, ABCA12
27	erythema multiforme	28.7	CD79A, CCL2, CCL17, CCL1, CCL5, ICAM1
28	epidermolytic palmoplantar keratoderma	28.7	EVPL, KRT16, KRT17, KRT1, KRT9
29	herpes gestationis	28.6	CD79A, COL17A1, RNASE3, C4A, DSG1, DST
30	food allergy	28.5	S100A8, CETP, IL13, IL4, IL5, CCL11
31	bronchitis	28.4	PDE4A, SELL, VDR, IL17A, MAPK14, CASP1
32	chronic obstructive pulmonary disease	28.3	PI3, PDE4A, SFTPD, ATP2A2, MPO, MMP1
33	rosacea	28.1	VDR, S100A8, CETP, IL18, IL8, CAMP
34	vaccinia	28.0	KLHL2, BDKRB1, CIITA, CHUK, BAK1, CD8A
35	cowpox	28.0	KLHL2, GZMB, IL18, IL18BP, CASP1, CASP8
36	exanthem	27.8	CD4, GZMB, IL5, CCL27, CCL11
37	psoriatic arthritis	27.6	SELE, MMP1, IL13, IL1A, IL1B, HLA-C
38	cutaneous t cell lymphoma	27.6	SELE, SELL, ITGAL, GZMB, IL2, IL2RA
39	tonsillitis	27.6	BDNF, BCL2, S100A7, CD79A, CD4, CD40
40	allergic rhinitis	27.5	SELE, VIP, VCAM1, IL13, IL4, IL5
41	juvenile rheumatoid arthritis	27.4	S100A8, S100A9, IL18R1, IL1A, IL1RN, IL2RA
42	behcet's disease	27.4	SELE, SELL, IL18, IL2RA, IL8, IFNA1
43	secondary syphilis	27.3	CYP3A4, CYP3A43, CYP2A6, CYP2B6, CYP2C19, CYP2D7P1
44	pemphigus vulgaris	27.3	CIITA, JUP, CD79A, CDH3, IVL, MMP9
45	dermatitis	27.2	PI3, KLHL2, PDE4A, SFTPD, BTD, SELE
46	paget's disease of bone	27.2	VDR, IL1B, IL6, IL8, ALPL, ALPP
47	interstitial lung disease	27.2	VTN, SFTPD, IL1A, IL1RN, IL8, CCL2
48	eosinophilia	27.2	PDE4A, SFTPD, SELL, VCAM1, MPO, CD79A
49	alopecia	27.1	BTD, VDR, CIITA, MX1, CD79A, CD4
50	graft versus host disease	27.0	SELL, CD28, ITGAL, GZMB, FGF7, IL10

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 alclometasone, alclometasone dipropionate, alitretinoin, amcinonide, botulinum toxin type a, botulinum toxin type b, clobetasol, clobetasol propionate, cod liver oil [va product], gotu kola, gotu kola liquid [va product], menthol, polymyxin b, polymyxin b sulfate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product], racemethionine, vitamin a, vitamin a (as acetate & beta carotene), vitamin a (as acetate), vitamin a (as palmitate & beta carotene), vitamin a (natural), vitamin a acetate, vitamin a palmitate, vitamin a palmitate (solubilized)

MalaCards organs/tissues related to skin disease:

²²

FMA organs/tissues related to skin disease:

¹¹

MGI Mouse Phenotypes related to skin disease:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	INF	BTD, SELP, BDKRB1, BCL2, CHUK, BAK1
2	digestive/alimentary phenotype	MP:0005381	INF	VDR, MYC, BDNF, BCL2, LAMA3, LAMB3
3	homeostasis/metabolism phenotype	MP:0005376	INF	VTN, SFTPD, BTD, SELE, SELL, SELP
4	integument phenotype	MP:0010771	INF	BTD, SELP, MYC, BECN1, BDKRB1, BDNF
5	embryogenesis phenotype	MP:0005380	INF	MYC, BECN1, CHUK, ATP2C1, MRC1, JUP
6	hematopoietic system phenotype	MP:0005397	INF	PCNA, BCL2, CHUK, BAK1, CD28, CD8A
7	tumorigenesis	MP:0002006	INF	SELL, MYC, BECN1, BCL2, CHUK, ATP2A2
8	limbs/digits/tail phenotype	MP:0005371	10.8	VDR, SCD, CHUK, BAK1, LAMC2, ITGA6
9	respiratory system phenotype	MP:0005388	10.8	SFTPD, SELL, SELP, BDNF, CCR4, ALPL
10	endocrine/exocrine gland phenotype	MP:0005379	10.7	SELL, CDSN, CDH3, MITF, FGFR2, IL2
11	hearing/vestibular/ear phenotype	MP:0005377	10.3	VDR, MYC, BDNF, BCL2, CHUK, BAK1
12	reproductive system phenotype	MP:0005389	10.1	VIP, VDR, BECN1, CHUK, ATP2A2, MRC1
13	other phenotype	MP:0005395	9.8	LAMC2, ITGA6, ITGB1, FN1, IRF2, IL13
14	liver/biliary system phenotype	MP:0005370	9.6	UROD, SCD, IL2, IL22, IL6, FABP5
15	nervous system phenotype	MP:0003631	9.1	PDE4A, SELP, MYC, BECN1, BDNF, CHUK
16	skeleton phenotype	MP:0005390	8.8	VDR, MYC, CHUK, BAK1, LAMC2, CD68
17	pigmentation phenotype	MP:0001186	8.4	BTD, MYC, BCL2, ITGB1, ITGB2, MITF
18	vision/eye phenotype	MP:0005391	8.2	NCAM1, BTD, SELE, SELP, BDNF, BCL2
19	muscle phenotype	MP:0005369	7.9	BTD, MYC, BCL2, ATP2A2, MPO, JUP
20	adipose tissue phenotype	MP:0005375	7.6	MYC, BCL2, FLT4, FGFR2, IL18, IL6
21	growth/size phenotype	MP:0005378	INF	SFTPD, BTD, SELE, SELP, VDR, VCAM1
22	normal phenotype	MP:0002873	INF	VTN, SELE, VIP, MYC, BDKRB1, BDNF
23	cellular phenotype	MP:0005384	INF	NCAM1, PCNA, SELE, SELL, SELP, VDR
24	behavior/neurological phenotype	MP:0005386	INF	NCAM1, BTD, SELE, SELP, VIP, BDKRB1
25	immune system phenotype	MP:0005387	INF	PDE4A, SELL, SELP, VDR, BDKRB1, CIITA
26	no phenotypic analysis	MP:0003012	INF	PCNA, VCAM1, MYC, BDNF, CD79A, CD4
27	mortality/aging	MP:0010768	INF	NCAM1, SFTPD, SELE, SELP, VDR, VCAM1
28	cardiovascular system phenotype	MP:0005385	INF	PDE4A, SELE, SELL, SELP, VDR, VCAM1
29	craniofacial phenotype	MP:0005382	INF	BDNF, LAMA3, LAMB3, ATP2C1, FLG, MITF

Articles related to skin disease:

(show top 50)    (show all 128)

id	Title	Authors	Year	Affiliating Genes
1	Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (21839423)	Onoufriadis A.... Barker J.N.	2011	IL36RN
2	Soluble adenylyl cyclase defines a nuclear cAMP micro domain in keratinocyte hyperproliferative skin diseases. (20130594)	Zippin J.H.... Magro C.M.	2010	CREB1, ADCY10
3	Aberrant upregulation of MUC4 mucin expression in cut aneous condyloma acuminatum and squamous cell carcinoma suggests a potential ro le in the diagnosis and therapy of skin diseases. (20591909)	Chakraborty S.... Batra S.K.	2010	MUC4
4	Development of atopic dermatitis-like skin disease fr om the chronic loss of epidermal caspase-8. (21135236)	Li C.... Jamora C.	2010	CASP8
5	Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytes. (18987669)	Lee J.R.... White T.W.	2009	GJB2
6	Connexin-26 mutations in deafness and skin disease. (19939300)	Lee J.R.... White T.W.	2009	GJB2
7	Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness. (17428836)	Gerido D.A.... White T.W.	2007	GJB2
8	Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases. (17988337)	Liu H.... Tu Y.	2007	PCNA, MCM5
9	Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. (17620096)	Wolf R.... Ruzicka T.	2007	S100A14, S100A7A
10	Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases. (16433682)	Bylaite M.... Walz M.	2006	CTSL1, SERPINB13
11	Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. (16815152)	Sicherer S.H.... Leung D.Y.	2006	IGHE
12	Inhibition of IFN-gamma as a method of treatment of various autoimmune diseases, including skin diseases. (16329644)	Skurkovich B.... Skurkovich S.	2006	IFNG
13	11 IL-1 family members in inflammatory skin disease. (16329652)	Sims J.... Blumberg H.	2006	IL18
14	Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. (16859899)	Saeki H.... Tamaki K.	2006	TNF, IL4, IFNG
15	Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. (16163348)	Zenz R.... Wagner E.F.	2005	PSORS6
16	Normal and abnormal mechanisms of gene splicing and relevance to inherited skin diseases. (16054339)	Wessagowit V.... McGrath J.A.	2005	COL7A1
17	Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. (15990789)	Sicherer S.H.... Leung D.Y.	2005	CETP, IGHE
18	Localization of haptoglobin in normal human skin and some skin diseases. (15811077)	Li P.... Xie Y.	2005	HP
19	T-cell dynamics of inflammatory skin diseases. (20476987)	Shiohara T.... Hayakawa K.	2005	CCBP2
20	The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases. (15097948)	Weiss E.... Sauder D.N.	2004	IL10
21	Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease. (15369222)	Honeycutt K.A.... Roop D.R.	2004	MYC, TP63
22	p53 protein expression and cell proliferation in non-neoplastic and neoplastic proliferative skin diseases. (15143984)	Batinac T.... Petrovecki M.	2004	TP53, MKI67
23	Targetting of desmoglein 1 in inherited and acquired skin diseases. (12823304)	Whittock N.V.... Bower C.	2003	JUP, DSG1
24	Development of spliceosome-mediated RNA trans-splicing (SMaRT) for the correction of inherited skin diseases. (12631245)	Dallinger G.... Bauer J.W.	2003	COL17A1
25	IL-20: a new target for the treatment of inflammatory skin disease. (12667095)	Rich B.E.	2003	IL24, IL19, IL20
26	Eotaxins and CCR3 receptor in inflammatory and allergic skin diseases: therapeutical implications. (14561178)	Amerio P.... Puddu P.	2003	CCL11
27	Targeting tumor necrosis factor-alpha as a potential therapy in inflammatory skin diseases. (12476958)	Girolomoni G.... Cavani A.	2002	TNF
28	A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. (11590199)	Albanesi C.... Girolomoni G.	2001	CXCR3, CCL1
29	R32W variant in Connexin 31: mutation or polymorphism for deafness and skin disease? (11175305)	Lopez-Bigas N.... Estivill X.	2001	GJB3
30	Molecular evaluation of vitamin D3 receptor agonists designed for topical treatment of skin diseases. (11348471)	Bury Y.... Carlberg C.	2001	VDR, CYP27B1
31	IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis. (11564829)	McInnes I.B.... Boumpas D.T.	2001	IL10
32	Keratinocytes express the CD146 (Muc18/S-endo) antigen in tissue culture and during inflammatory skin diseases. (10951239)	Weninger W.... Tschachler E.	2000	MCAM
33	Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. (11121144)	Presland R.B.... Sundberg J.P.	2000	FLG
34	Acquired skin disease of hemidesmosomes. (10379705)	Zillikens D.	1999	COL17A1
35	Autoimmune bullous skin diseases (10220817)	Joly P.	1999	COL17A1
36	Distinct serum cytokines in AIDS-related skin diseases. (10189188)	Breuer-McHam J.N.... Duvic M.	1998	TNF, IL4, IFNG
37	Monitoring of serologic immune parameters in inflammatory skin diseases. (9404560)	Gebhardt M.... Wollina U.	1997	IL2RA, RNASE3, IGHE
38	A transgenic mouse model that recapitulates the clinical features of both neonatal and adult forms of the skin disease epidermolytic hyperkeratosis. (8983179)	Bickenbach J.R.... Roop D.R.	1996	KRT10
39	Overexpression of amphiregulin, a major autocrine growth factor for cultured human keratinocytes, in hyperproliferative skin diseases. (8739992)	Piepkorn M.	1996	AREG
40	Essential trace element and skin diseases (8587213)	Yamada H.... Ogawa H.	1996	QSOX2
41	Finasteride inhibits 5 alpha-reductase activity in human dermal fibroblasts: prediction of its therapeutic application in androgen-related skin diseases. (8537164)	Nguyen Q.H.... Chien P.	1995	SRD5A1
42	Dietary supplementation with very long-chain n-3 fatty acids in man decreases expression of the interleukin-2 receptor (CD25) on mitogen-stimulated lymphocytes from patients with inflammatory skin diseases. (8050452)	SA... Drevon A.	1994	IL2RA, IL6, IL2
43	The role of complement-derived mediators in inflammat ory skin diseases. (1285651)	Tagami H.	1992	C5AR1
44	A bullous skin disease patient with autoantibodies against separate epitopes in 1 mol/L sodium chloride split skin. (1379792)	Domloge-Hultsch N.... Yancey K.B.	1992	DST
45	Alpha-6 (CD 49f) integrin expression in genetic and a cquired bullous skin diseases. A comparison of its distribution with bullous pe mphigoid antigen. (1474190)	Kanitakis J.... Thivolet J.	1992	ITGA6
46	Vitamin D3 and skin diseases. (1337425)	Kragballe K.	1992	NR1H2
47	Evaluation of transforming growth factor beta and type I procollagen gene expression in fibrotic skin diseases by in situ hybridization. (2307855)	Peltonen J.... Jimenez S.A.	1990	TGFB1
48	Hemostasis in patients with systemic skin diseases (2278192)	DovzhanskiA- S.I.... Rumiantseva E.V.	1990	F2
49	The role of epidermal cytokines in inflammatory skin diseases. (2230203)	Sauder D.N.	1990	IL18R1
50	Immunopathological study of proliferation-associated antigens in proliferative skin diseases (2197470)	Baba N.	1990	KRT17

Genes related to skin disease according to GeneCards:

(show top 50)    (show all 275)

id	Symbol	Description	Score	GeneCards Section Context
1	LOR	loricrin	11.0	Summaries, Publications
2	LAMC2	laminin, gamma 2	11.0	Publications, Summaries
3	KWE	keratolytic winter erythema (Oudtshoorn skin disease)	11.0	Aliases & Descriptions
4	COL17A1	collagen, type XVII, alpha 1	11.0	Publications
5	TGM1	transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
6	DST	dystonin	11.0	Publications
7	GJB4	gap junction protein, beta 4, 30.3kDa	11.0	Publications
8	GJB3	gap junction protein, beta 3, 31kDa	11.0	Publications
9	KRT9	keratin 9	11.0
10	ECM1	extracellular matrix protein 1	11.0
11	DSG1	desmoglein 1	11.0	Publications
12	COL7A1	collagen, type VII, alpha 1	11.0	Publications
13	KRT10	keratin 10	11.0	Publications
14	KRT6A	keratin 6A	11.0
15	DSG3	desmoglein 3	11.0	UniProt Related, Publications
16	KRT14	keratin 14	11.0	Publications
17	KRT1	keratin 1	11.0	Publications
18	LAMB3	laminin, beta 3	11.0
19	ADAR	adenosine deaminase, RNA-specific	11.0
20	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
21	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
22	IL8	interleukin 8	11.0	Publications
23	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0
24	TNF	tumor necrosis factor	11.0	Publications
25	CDSN	corneodesmosin	11.0	Publications
26	IL31	interleukin 31	11.0
27	TDGF1P3	teratocarcinoma-derived growth factor 1 pseudogene 3	11.0
28	SERPINB13	serpin peptidase inhibitor, clade B (ovalbumin), member 13	11.0	Publications
29	SPRR3	small proline-rich protein 3	11.0	Publications
30	LELP1	late cornified envelope-like proline-rich 1	11.0	Publications
31	SPRR1B	small proline-rich protein 1B	11.0	Publications
32	EVPL	envoplakin	11.0
33	KLK7	kallikrein-related peptidase 7	11.0	Publications
34	DCD	dermcidin	11.0
35	DEFB103B	defensin, beta 103B	11.0
36	MMP26	matrix metallopeptidase 26	11.0
37	TCHH	trichohyalin	11.0
38	LAD1	ladinin 1	11.0
39	CCR10	chemokine (C-C motif) receptor 10	11.0
40	PPOX	protoporphyrinogen oxidase	11.0
41	SLURP1	secreted LY6/PLAUR domain containing 1	11.0
42	CD7	CD7 molecule	11.0
43	CD1C	CD1c molecule	11.0
44	PI3	peptidase inhibitor 3, skin-derived	11.0
45	KRT17	keratin 17	11.0	Publications
46	FABP5	fatty acid binding protein 5 (psoriasis-associated)	11.0
47	IL22	interleukin 22	11.0
48	CSTA	cystatin A (stefin A)	11.0
49	S100A7	S100 calcium binding protein A7	11.0	Publications
50	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	11.0

Pathways related to skin disease according to GeneDecks:

(show top 50)    (show all 166)

id	Pathway	Score	Top Affiliating Genes
1	Transendothelial Migration of Leukocytes36	11.5	VCAM1, LAMA3, LAMB3, LAMC2, ITGA6, ITGAL
2	IL-6 Pathway36	11.2	IL10, IL18, IL19, IL20, IL22, IL24
3	Rho Family GTPases36	11.1	BDNF, BCL2, LAMA3, LAMB3, LAMC2, CDH3
4	ILK Signaling36	11.1	BDNF, LAMA3, LAMB3, LAMC2, CDH3, ITGB1
5	RAR-Gamma-RXR-Alpha Degradation36	10.8	IL19, IL2, IL20, IL22, IL24, IL3
6	Akt Signaling36	10.8	CHUK, CD28, CD4, ITGA6, ITGAL, ITGB2
7	UPA-UPAR Pathway36	10.8	VTN, LAMA3, LAMB3, LAMC2, ITGA6, ITGAL
8	Regulation of eIF4 and p70S6K36	10.5	CD4, ITGA6, ITGAL, ITGB1, ITGB2, FGF7
9	ERK Signaling36	10.5	MYC, CHUK, LAMA3, LAMB3, LAMC2, ITGA6
10	all-trans-Retinoic Acid Signaling in Brain36	10.4	BCL2, IL10, IL13, IL18, IL19, IL1A
11	Endothelin-1 Signaling Pathway36	10.4	MYC, FLT4, FGFR2, FGFR3, IL10, IL13
12	MIF Mediated Glucocorticoid Regulation36	10.3	BCL2, IL10, IL13, IL18, IL19, IL1A
13	PEDF Induced Signaling36	10.3	BDNF, BCL2, CHUK, IL10, IL13, IL18
14	Immune System38	10.3	NCAM1, VCAM1, CIITA, MX1, CD79A, CD40
15	PPAR Pathway36	10.2	ITGA6, ITGAL, ITGB1, ITGB2, ITGB4, FLT4
16	PGC1Alpha Pathway36	10.2	BCL2, CD4, IL13, IL18, IL19, IL1A
17	Toll-like receptor signaling pathway20	10.2	CHUK, CD40, IL1B, IL6, IL8, MAPK14
18	NFAT Signaling and Lymphocyte Interactions36	10.1	BCL2, CD4, FCER2, IL13, IL19, IL1A
19	Influenza A20	10.1	CIITA, MX1, IL18, IL1A, IL1B, IL6
20	Phospholipase-C Pathway36	10.1	BDNF, LAMA3, LAMB3, LAMC2, CD79A, ITGA6
21	Malaria20	10.0	SELE, SELP, VCAM1, CD40, ITGAL, ITGB2
22	Cytokine Network36	10.0	IL10, IL13, IL18, IL1A, IL1B, IL2
23	PAK Pathway36	10.0	BDNF, BCL2, FLT4, AREG, FGF7, FGFR2
24	Cell adhesion molecules (CAMs)20	9.9	NCAM1, SELL, SELP, CD28, CD8A, CD4
25	Tec Kinases Signaling36	9.9	BDNF, BCL2, CD28, CD4, ITGA6, ITGAL
26	PTEN Pathway36	9.9	BDNF, LAMA3, LAMB3, LAMC2, ITGA6, ITGAL
27	Cytokine-cytokine receptor interaction20	9.8	CD40, FLT4, IL10, IL13, IL17A, IL18
28	Toxoplasmosis20	9.8	BCL2, CIITA, CHUK, LAMA3, LAMB3, LAMC2
29	STAT3 Pathway36	9.7	MYC, BCL2, CD28, CD4, IL10, IL13
30	Hematopoietic cell lineage20	9.7	CD8A, CD4, CD1A, CD1C, CD7, ITGA6
31	Antioxidant Action of Vitamin-C36	9.6	BDNF, BCL2, CHUK, CD28, CD4, FLT4
32	Rheumatoid arthritis20	9.6	CD28, ITGAL, ITGB2, MMP1, IL17A, IL18
33	Glucocorticoid Receptor Signaling36	9.6	BCL2, CD4, IL10, IL13, IL18, IL18R1
34	SOCS Pathway36	9.5	BCL2, CD4, FGF7, IL10, IL13, IL18
35	MIF Regulation of Innate Immune Cells36	9.5	BCL2, IL10, IL13, IL18, IL19, IL1A
36	MAPK Family Pathway36	9.5	BDNF, BCL2, CHUK, CD4, FLT4, AREG
37	NF-KappaB Family Pathway36	9.5	BDNF, CHUK, FLT4, AREG, FGF7, FGFR2
38	TGF-Beta Pathway36	9.5	BDNF, BCL2, CD4, FLT4, AREG, FGF7
39	NF-KappaB (p50-p65) Pathway36	9.2	BDNF, CHUK, FLT4, AREG, FGF7, FGFR2
40	Molecular Mechanisms of Cancer36	8.9	MYC, BDNF, BCL2, BAK1, LAMB3, CD4
41	Tuberculosis20	8.8	VDR, BCL2, CIITA, MRC1, ITGB2, FCGR2A
42	Pathways in cancer20	8.7	MYC, BCL2, CHUK, JUP, ITGA6, ITGB1
43	MAPK Signaling36	8.7	MYC, BDNF, BCL2, CHUK, LAMA3, LAMB3
44	p38 Signaling36	8.6	BDNF, BCL2, CD28, CD4, FLT4, AREG
45	JAK-STAT Pathway36	8.6	MYC, BDNF, BCL2, CD4, FLT4, AREG
46	JNK Pathway36	8.5	BCL2, CD4, FLT4, AREG, FGF7, FGFR2
47	Cellular Apoptosis Pathway36	8.4	BDNF, BCL2, CHUK, BAK1, FLT4, AREG
48	Apoptotic Pathways in Synovial Fibroblasts36	8.4	BDNF, FLT4, AREG, FGF7, FGFR2, FGFR3
49	p53 Mediated Apoptosis36	8.1	BDNF, BCL2, FLT4, AREG, FGF7, FGFR2
50	Mitochondrial Apoptosis36	7.9	BDNF, BCL2, BAK1, FLT4, AREG, FGF7

Compounds related to skin disease according to GeneDecks:

(show top 50)    (show all 503)

id	Compound	Score	Top Affiliating Genes
1	fatty acid32	11.5	PI3, BTD, SCD, CHUK, S100A7, S100A8
2	endotoxin32	11.0	SFTPD, SELL, SERPINF2, CIITA, S100A8, S100A9
3	ionomycin32	10.9	CHUK, CD40, FCER2, IL3, IL5, IL7
4	glucose32	10.9	PDE4A, BTD, CHUK, BAK1, MKI67, GZMB
5	salbutamol32 34 9 18 9	14.8	PDE4A, VIP, VCAM1, CD79A, ITGB2, FCER2
6	tarc32	10.8	CD4, IL10, IL13, IL18, IL1A, IL4
7	agar32	10.8	JUP, FN1, FGF7, FGFR2, IL7, GJA1
8	nitric oxide32 9 18 9	13.8	NCAM1, PDE4A, SFTPD, SELE, SELP, VCAM1
9	forskolin32 42 9 9	13.7	PDE4A, VIP, BDNF, CD40, IVL, AREG
10	ivig32	10.7	IL18R1, IL3, CRP, ELN, DSG1, DSG3
11	methacholine32 9 9	12.7	VIP, MPO, CD79A, IL13, IL17A, IL4
12	cetirizine32 9 18 9	13.6	ITGAL, IL5, IL8, CCL11, IGHE, ICAM1
13	lipoteichoic acid32	10.5	SELE, IL10, IL18, IL1B, IL1RN, IL6
14	groalpha32	10.5	SELE, VCAM1, IL10, IL13, IL17A, IL18
15	ccl332	10.4	MMP9, IL10, IL13, IL18, IL1A, IL1B
16	polyethylene glycol32	10.3	VTN, SELE, VIP, MPO, FN1, IFNA2
17	gf 109203x32 42	11.2	IVL, MMP1, FN1, FLG, MAPK14, CCL5
18	sp 60012532 42	11.1	VCAM1, CD40, MMP1, FGF7, IL13, IL17A
19	rantes32	10.0	SELE, SELL, SELP, VIP, VCAM1, CIITA
20	superoxide32 18	10.9	PI3, PDE4A, SELL, VCAM1, CHUK, BAK1
21	polyinosinic-polycytidylic acid32	9.9	SELE, VCAM1, CIITA, CD40, IL10, IL18
22	phorbol32	9.9	SELL, MYC, CHUK, CD4, CD40, ITGAL
23	etanercept32 9 9	11.8	MMP1, FCGR2A, IL10, IL17A, IL18, IL18R1
24	wortmannin32 42	10.8	PI3, PDE4A, VTN, VCAM1, BDNF, BCL2
25	estradiol32 9 18 9	12.8	PCNA, BDNF, BAK1, ITGB1, MMP26, MKI67
26	pge232	9.8	PDE4A, VTN, SELE, VIP, VCAM1, CIITA
27	estrogen32	9.8	PCNA, VIP, VDR, BDNF, UROD, MUC4
28	parthenolide32	9.6	CHUK, MMP9, IL6, IL8, MAPK14, CCL2
29	pravastatin32 34 9 18 9	13.6	SELE, SELP, CETP, ITGAL, IL18, IL6
30	adenylate32	9.5	PDE4A, SELE, SELP, VIP, VDR, VCAM1
31	quercetin32 42 9 18 9	13.5	SELE, VCAM1, BCL2, CHUK, BAK1, ARSH
32	sb 20358032 42	10.5	PI3, SELE, VDR, VCAM1, BDKRB1, BCL2
33	rosiglitazone32 9 18 9	12.4	SELE, VCAM1, SCD, MMP1, MMP9, IL18
34	prostacyclin32	9.3	PDE4A, VTN, SELE, SELP, VIP, VCAM1
35	fluticasone propionate32 42 9 9	12.3	SELE, VCAM1, MPO, MMP9, IL13, IL1B
36	15-deoxy-delta-12,14-prostaglandin j232	9.3	VCAM1, MYC, IL10, IL1B, IL4, IL6
37	retinoic acid32 42 18	11.3	PI3, NCAM1, PDE4A, VTN, SELL, SELP
38	aspirin32 34 18	11.2	PDE4A, VTN, PCNA, SELE, SELL, SELP
39	pentoxifylline32 9 9	11.1	PDE4A, SELL, SELP, VCAM1, MPO, ITGB2
40	atorvastatin32 34 9 18 9	13.1	SELE, SELL, SELP, VCAM1, CETP, CD40
41	glutamine32	9.0	NCAM1, PDE4A, VTN, SFTPD, PCNA, SERPINF2
42	vitamin d32	9.0	VDR, CD79A, IVL, ITGB2, FN1, FGF7
43	simvastatin32 34 42 9 18 9	13.9	SELE, SELL, SELP, VCAM1, CIITA, CHUK
44	triptolide32	8.7	BCL2, CD40, IL1B, IL2, IL6, IL8
45	butyrate32	8.4	PCNA, VDR, MYC, BCL2, BAK1, MPO
46	paraffin32	8.0	NCAM1, PCNA, SELL, VCAM1, MYC, BCL2
47	actinomycin d32	7.9	PDE4A, SELE, VDR, MYC, BDKRB1, BDNF
48	lactate32	7.8	NCAM1, VTN, SFTPD, PCNA, BTD, SELE
49	genistein32 9 18 9	10.8	PCNA, SELE, SELL, SELP, VDR, VCAM1
50	lipid32	INF	PI3, NCAM1, PDE4A, VTN, SFTPD, SELE

Cellular components related to skin disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	ACHE, GJB2, GJA1, HRH1, CAT, HSPB1
2	cornified envelope	GO:001533	11.0	CSTA, TGM1, DSP, SPRR1B, EVPL, LOR
3	hemidesmosome	GO:030056	10.6	DST, COL17A1, PLEC, ITGB4, ITGB1, JUP
4	integral to plasma membrane	GO:005887	10.3	TNFSF10, TNF, HLA-DRB1, HLA-C, HLA-A, GJA1
5	membrane raft	GO:045121	10.1	TNF, TEK, EGFR, DPP4, PRNP, GJA1
6	external side of plasma membrane	GO:009897	9.4	CXCR3, CD8A, CD79A, CD28, VCAM1, SELP
7	cell surface	GO:009986	9.3	CYP3A4, NGFR, ELANE, HBEGF, TLR2, TGFA
8	extracellular region	GO:005576	8.2	C3, KNG1, SIGLEC1, LYZ, SLURP1, NPS
9	extracellular space	GO:005615	8.0	IL3, CETP, S100A9, S100A8, LAMC2, VCAM1
10	desmosome	GO:030057	INF	DSP, DSG4, DSG3, DSG1, DSC3, DSC1
11	intermediate filament	GO:005882	INF	DST, DSP, KRT14, KRT10, KRT1, KRT17

Biological processes related to skin disease according to GeneDecks:

(show top 50)    (show all 53)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell junction assembly	GO:034329	INF	, , PLEC, COL17A1, KRT5, KRT14
2	epidermis development	GO:008544	12.7	KRT1, KRT17, KRT16, KRT5, COL17A1, COL7A1
3	keratinocyte differentiation	GO:030216	11.8	CSTA, S100A7, CDSN, IVL, TGM3, TGM1
4	chemotaxis	GO:006935	11.7	C3AR1, C5AR1, CXCR3, CXCR1, CXCL9, CXCL11
5	hemidesmosome assembly	GO:031581	11.6	DST, KRT14, KRT5, COL17A1, PLEC, ITGB4
6	keratinization	GO:031424	11.4	TCHH, TGM3, TGM1, SPRR3, SPRR1B, EVPL
7	peptide cross-linking	GO:018149	11.4	LOR, FN1, IVL, F13A1, EVPL, SPRR1B
8	cell-matrix adhesion	GO:007160	11.2	SIGLEC1, COL17A1, CTGF, SRF, TEK, ITGB4
9	inflammatory response	GO:006954	11.1	CXCL10, TAC1, TACR1, TGFB1, TLR2, C4A
10	wound healing	GO:042060	11.0	TGFA, DSP, PPARD, PPARA, SPRR3, LOX
11	cell-cell signaling	GO:007267	10.9	IL2, IL1B, IL18, IL17A, IL13, IL10
12	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.8	PRKCA, CTGF, TEK, TNF, IL1B, IL1A
13	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.8	CASP8, GJA1, TNF, TNFSF10, ECM1, CASP1
14	response to wounding	GO:009611	10.7	TGFB1, DST, ACHE, KLK6, NGFR, CTGF
15	leukocyte cell-cell adhesion	GO:007159	10.6	ICAM1, CCL5, ITGB2, ITGB1, ITGAL, VCAM1
16	angiogenesis	GO:001525	10.6	CTGF, NRP2, EGF, TGFA, TGFBI, PRKCA
17	regulation of immune response	GO:050776	10.6	ICAM1, ICAM3, HLA-A, HLA-C, C3, IL4
18	cellular response to mechanical stimulus	GO:071260	10.6	TNFRSF8, CASP8, CASP1, IL1B, IL18, IL13
19	lipopolysaccharide-mediated signaling pathway	GO:031663	10.5	STAT1, TGFB1, TLR2, TNF, CCL5, CCL2
20	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.4	CAT, TNF, TNFRSF8, TLR2, TGFB1, ICAM1
21	positive regulation of angiogenesis	GO:045766	10.4	C3AR1, C3, ECM1, PRKCA, TEK, CCL5
22	cellular calcium ion homeostasis	GO:006874	10.3	PRKCA, TGFB1, ELANE, CCL5, CCL1, CCL11
23	positive regulation of nitric oxide biosynthetic process	GO:045429	10.3	EGFR, TNF, HRH1, ICAM1, IFNG, IL1B
24	positive regulation of smooth muscle cell proliferation	GO:048661	10.3	PRKCA, STAT1, HBEGF, ELANE, TNF, CCL5
25	cellular response to organic cyclic compound	GO:071407	10.3	TGFB1, PPARG, SRD5A1, TNF, ALPL, CCL5
26	elevation of cytosolic calcium ion concentration	GO:007204	10.3	C3AR1, C5AR1, KNG1, CXCR3, TAC1, TACR1
27	response to lipopolysaccharide	GO:032496	10.2	CXCL10, TAC1, ELANE, CYP27B1, CASP8, SELE
28	response to ethanol	GO:045471	10.2	ICAM1, CASP8, TACR1, PRF1, PRKCA, CCL2
29	positive regulation of protein phosphorylation	GO:001934	10.1	F2, TNF, TEK, CTGF, TGFB1, PRKCA
30	negative regulation of growth of symbiont in host	GO:044130	10.1	TLR2, ELANE, TNF, CAMP, IFNG, IL10
31	positive regulation of T cell proliferation	GO:042102	10.1	IFNG, CCL5, IL6, IL4, IL1B, ITGAL
32	leukocyte migration	GO:050900	10.1	FN1, ICAM1, F2, TEK, ELANE, MMP1
33	MAPK cascade	GO:000165	9.9	TGFB1, TGFA, EGFR, TNF, CCL5, CCL2
34	immune response	GO:006955	9.9	CD1A, CD4, CD8A, CHUK, CIITA, VTN
35	anti-apoptosis	GO:006916	9.8	IKBKB, HSPB1, TNF, TEK, NGFR, TGFA
36	innate immune response	GO:045087	9.7	CASP1, CASP8, CTSL1, PPARG, CREB1, C4A
37	response to hypoxia	GO:001666	9.7	TNF, SRF, PPARA, CRP, TGFB1, DPP4
38	response to drug	GO:042493	9.6	IFNG, ICAM1, GNPAT, CASP1, TNF, SRD5A1
39	protein tetramerization	GO:051262	9.3	CCL5, CAT, HMGCR, HLA-DRB1, TP53, ACHE
40	interferon-gamma-mediated signaling pathway	GO:060333	9.3	STAT1, PTAFR, HLA-DRB1, HLA-C, HLA-A, ICAM1
41	positive regulation of cell proliferation	GO:008284	9.2	CTGF, PPARD, KRT6A, EGF, EGFR, TGFB1
42	response to antibiotic	GO:046677	9.1	PRKCA, TP53, CASP8, ALPL, CCL2, AOC3
43	cytokine-mediated signaling pathway	GO:019221	9.0	IFNG, ICAM1, HLA-A, HLA-C, HLA-DRB1, PTAFR
44	response to gamma radiation	GO:010332	8.9	CXCL10, TP53, CCL2, IL1B, IL1A, BAK1
45	blood coagulation	GO:007596	8.5	F13A1, ALB, F2, IFNA2, TP53, TEK
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	SRF, TNF, TP63, TP53, IFNG, PPARG
47	cell adhesion	GO:007155	INF	DST, DSC3, ACHE, , COL7A1, NRP2
48	apoptotic process	GO:006915	INF	PLEC, PPARD, TNFSF10, TNF, TP63, TP53
49	signal transduction	GO:007165	INF	EGFR, EGF, KRT17, , CREB1, CRABP2
50	cell-cell adhesion	GO:016337	INF	EGFR, DSG1, DSP, CSTA, SIGLEC1, TEK

Molecular functions related to skin disease according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	11.1	CXCL9, CXCL11, CXCL10, CCL5, CCL18, CCL1
2	calcium ion binding	GO:005509	10.9	EGF, DSC1, DSC3, DSG1, DSG3, DSG4
3	integrin binding	GO:005178	10.6	TGFBI, DST, CTGF, ICAM3, ICAM1, FCER2
4	cytokine activity	GO:005125	10.4	IL10, IL4, IL5, IL6, IL7, IFNA2
5	receptor binding	GO:005102	9.9	HLA-A, TNC, TNFSF10, DPP4, CXCL10, POMC
6	heparin binding	GO:008201	9.8	CCL5, CTGF, NRP2, ELANE, HBEGF, KNG1
7	heme binding	GO:020037	9.6	CYP2J2, CYP3A5, CYP27B1, CYP4X1, CYP2C19, CYP2S1
8	iron ion binding	GO:005506	9.4	CYP2C19, CYP4X1, CYP27B1, CYP3A5, CYP2J2, CYP2S1
9	growth factor activity	GO:008083	9.4	F2, CTGF, EGF, HBEGF, TGFA, TGFB1
10	protease binding	GO:002020	9.3	ELANE, DPP4, CSTA, ECM1, TNF, TP53
11	structural constituent of cytoskeleton	GO:005200	INF	, KRT9, KRT14, DSP, KRT1, KRT17
12	protein binding	GO:005515	INF	NR1H2, PPARA, PPARG, CTSL1, SPRR3, CREB1