MCID: SKN016
MIFTS: 75

Skin Disease malady

Skin diseases category
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Summaries for Skin Disease

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Wikipedia:65 A cutaneous condition is any medical condition that affects the integumentary system ? the organ system... more...

MalaCards based summary: Skin Disease, also known as dermatitis due to unspecified substance taken internally, is related to bullous skin disease and bullous pemphigoid. An important gene associated with Skin Disease is LAMC2 (laminin, gamma 2), and among its related pathways are a6b1 and a6b4 Integrin signaling and Cytokine Network. The drugs prednisolone and prednisone and the compounds ena 78 and rebamipide have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and t cells, and related mouse phenotypes are digestive/alimentary and integument.

Disease Ontology:8 An integumentary system disease that is located in skin.

Aliases & Classifications for Skin Disease

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Skin Disease, Aliases & Descriptions:

Name: Skin Disease 30 8 10
Dermatitis Due to Unspecified Substance Taken Internally 8
Dermatitis Due to Substances Taken Internally 8
Skin and Subcutaneous Tissue Disease 8
Skin Diseases, Genetic 62
Dermatologic Disorders 62
 
Skin Diseases Genetic 44
Genetic Skin Disease 8
Genodermatosis, Nos 8
Genodermatosis 8
Skin Diseases 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Related Diseases for Skin Disease

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Diseases related to Skin Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1122)
idRelated DiseaseScoreTop Affiliating Genes
1bullous skin disease31.0DST, COL17A1, CCL5
2bullous pemphigoid30.8ITGA6, DST, COL17A1
3arthritis30.7TNF, IL8
4psoriasis30.6CDSN, IL8, CCL5, DST, TNF
5mucous membrane pemphigoid30.6COL17A1
6herpes gestationis30.5DST, COL17A1
7epidermolysis bullosa acquisita30.4LAMC2, DST, COL17A1
8atopic dermatitis30.4TNF, IL8, ITGA6, CCL5, CDSN
9lichen planus30.3DST, LAMC2, COL17A1
10epidermolysis bullosa30.3ITGA6, COL17A1, LAMC2, DST
11junctional epidermolysis bullosa30.2COL17A1, LAMC2
12junctional epidermolysis bullosa, non-herlitz type30.2COL17A1, DST
13ankylosing spondylitis30.2TNF
14epidermolysis bullosa simplex30.1DST, COL17A1
15behcet's disease30.1IL8, TNF
16basal cell carcinoma30.0LAMC2, DST, COL17A1
17erythrokeratodermia variabilis30.0GJB3, GJB4
18osteoarthritis29.7TNF, CCL5, ITGA6, IL8
19clouston syndrome29.7GJB3, GJB4
20melanoma29.6LAMC2, IL8, ITGA6, DST, TNF
21ocular cicatricial pemphigoid10.5ITGA6
22periapical granuloma10.5CCL5
23dermatitis10.4
24viral meningitis10.4CCL5, IL8
25alcoholic hepatitis10.4TNF, IL8
26vernal keratoconjunctivitis10.3IL8, CCL5
27chorioamnionitis10.3TNF, IL8
28extrinsic allergic alveolitis10.3IL8, CCL5
29bronchiolitis10.3IL8, CCL5
30idiopathic pulmonary fibrosis10.3CCL5, IL8, LAMC2
31contact dermatitis10.3
32acne10.3
33allergic contact dermatitis10.3
34periodontal disease10.3TNF, IL8, LAMC2
35demyelinating disease10.3TNF, CCL5
36interstitial lung disease10.3IL8, CCL5
37irritant dermatitis10.3
38lupus erythematosus10.3
39endometriosis10.3CCL5, IL8, ITGA6
40granulomatous slack skin disease10.2
41pulmonary sarcoidosis10.2CCL5, TNF
42chronic obstructive pulmonary disease10.2IL8, CCL5, TNF
43pemphigus10.2
44cork-handlers' disease10.2IL8, TNF, CCL5
45pneumonia10.2TNF, IL8, CCL5
46adult respiratory distress syndrome10.2IL8, TNF
47hypersensitivity reaction type ii disease10.1CCL5, DST, TNF, COL17A1
48rosacea10.1
49ulcerative colitis10.1IL8, LAMC2, TNF
50vitiligo10.1

Graphical network of the top 20 diseases related to Skin Disease:



Diseases related to skin disease

Symptoms for Skin Disease

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Drugs & Therapeutics for Skin Disease

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Drug clinical trials:

Search ClinicalTrials for Skin Disease

Search NIH Clinical Center for Skin Disease

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Skin Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Skin Disease:
JACE
Embryonic/Adult Cultured Cells Related to Skin Disease:
Cultured epidermis (JACE, PMIDs: 23265935, 17465819, 11987545

Genetic Tests for Skin Disease

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Anatomical Context for Skin Disease

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MalaCards organs/tissues related to Skin Disease:

32
Skin, T cells, Testes, Neutrophil, Eye, Bone, Endothelial, Kidney, Liver, Bone marrow, Thymus, Colon, Lung, Thyroid, Myeloid, Monocytes, B cells

FMA organs/tissues related to Skin Disease:

14
Skin

Animal Models for Skin Disease or affiliated genes

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MGI Mouse Phenotypes related to Skin Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9TNF, LAMC2, DST, ITGA6, IQGAP1
2MP:00107718.6CDSN, TNF, LAMC2, DST, ITGA6, COL17A1
3MP:00053878.5TNF, LAMC2, CCL5, ITGA6, IL8, COL17A1
4MP:00107688.4LAMC2, DST, ITGA6, IQGAP1, COL17A1, GJB3

Publications for Skin Disease

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Articles related to Skin Disease:

(show top 50)    (show all 678)
idTitleAuthorsYear
1
Anti-RNA polymerase III antibodies in the diagnosis of scleroderma renal crisis in the absence of skin disease. (25275766)
2014
2
Phase I study protocol for ex-vivo lentiviral gene therapy for the inherited skin disease, Netherton Syndrome. (24138501)
2013
3
IgG4-related skin disease successfully treated by thalidomide: a report of 2 cases with emphasis on pathological aspects. (23572226)
2013
4
Tungiasis - A Janus-faced parasitic skin disease. (24211240)
2013
5
Lumpy skin disease of cattle: an emerging problem in the Sultanate of Oman. (24097247)
2013
6
Analysis of high-dose intravenous immunoglobulin therapy in 16 patients with refractory autoimmune blistering skin disease: high efficacy and no serious adverse events. (23073990)
2013
7
Skin disease in individuals with liver and kidney transplants: influence of skin phototype and transplanted organ. (23895208)
2013
8
Genetic skin diseases predisposing to basal cell carcinoma. (22391625)
2012
9
Associations between skin diseases and quality of life: a comparison of psoriasis, vitiligo, and alopecia areata. (22930385)
2012
10
Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. (22615377)
2012
11
Skin disease in dermatomyositis. (22907594)
2012
12
Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. (21839423)
2011
13
Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down. (22103940)
2011
14
Neutrophils require SHP1 to regulate IL-1I^ production and prevent inflammatory skin disease. (21160041)
2011
15
Usage of complementary and alternative medicine for management of skin disease. (21936703)
2011
16
Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases. (20636397)
2010
17
Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo. (20300524)
2010
18
Anakinra for difficult-to-treat neutrophilic panniculitis: IL-1 blockade as a promising treatment option for neutrophil-mediated inflammatory skin disease. (20197651)
2010
19
Dermatoses affecting desmosomes in animals: a mechanistic review of acantholytic blistering skin diseases. (20178467)
2009
20
Patients with skin disease and their relationships with their doctors: a qualitative study of patients with acne, psoriasis and eczema. (19236289)
2009
21
Is psoriasis a skin disease or a form of arthritis? (19768838)
2009
22
Temporary tattoos to simulate skin disease: report and validation of a novel teaching tool. (19550194)
2009
23
Evaluation of the Cutaneous Lupus Activity and Severity Score in the assessment of lupus erythematosus skin disease. (17941937)
2008
24
Quantitative real-time RT-PCR measurement of cytokine mRNA expression in the skin of normal cats and cats with allergic skin disease. (18191230)
2008
25
Measurement of family impact of skin disease: further validation of the Family Dermatology Life Quality Index (FDLQI). (18312324)
2008
26
Meeting report of immunology and skin disease: new perspectives. (17632556)
2007
27
Therapy-resistent lupus skin disease successfully treated with rituximab. (16690759)
2006
28
Treating skin disease: self-management behaviors of Latino farmworkers. (17135140)
2006
29
Involving the patient: impact of inflammatory skin disease and patient-focused care. (15968267)
2005
30
Arthritis and skin disease. (16282751)
2005
31
The biology of Malassezia organisms and their ability to induce immune responses and skin disease. (15725101)
2005
32
The emotional impact of chronic and disabling skin disease: a psychoanalytic perspective. (16112437)
2005
33
Pimecrolimus for the treatment of inflammatory skin disease. (15013932)
2004
34
Defining the burden of skin disease in the United States--a historical perspective. (15083775)
2004
35
The allergy and immunology specialist: what is the role in the treatment of skin disease? (15576896)
2004
36
Prevalence of skin disease in HIV-positive pregnant women. (12839600)
2003
37
Use of a polymerase chain reaction assay to detect bovine herpesvirus type 2 DNA in skin lesions from cattle suspected to have pseudo-lumpy skin disease. (12762387)
2003
38
Etanercept ameliorates sarcoidosis arthritis and skin disease. (12913948)
2003
39
Implication of a healthcare worker with chronic skin disease in the transmission of an epidemic strain of methicillin-resistant Staphylococcus aureus in a pediatric intensive care unit. (12725361)
2003
40
Patients' and doctors' assessment of skin disease handicap. (12072021)
2002
41
Importance of thymidine kinase activity for normal growth of lumpy skin disease virus (SA-Neethling). (11958465)
2002
42
Lumpy skin disease in southern Africa: a review of the disease and aspects of control. (11513262)
2001
43
A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. (11590199)
2001
44
Questions answered and a $1 million question raised concerning lupus erythematosus tumidus: is routine laboratory surveillance testing during treatment with hydroxychloroquine for skin disease really necessary. (10926741)
2000
45
The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases. (10666397)
2000
46
Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. (10815854)
2000
47
Differential expression of CRABP II, psoriasin and cytokeratin 1 mRNA in human skin diseases. (8844119)
1996
48
Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases. (8763423)
1996
49
Development of interferon antibodies during the treatment of skin diseases with low-dose recombinant interferon alpha-2a]. (8597337)
1995
50
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990

Variations for Skin Disease

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Expression for genes affiliated with Skin Disease

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Expression patterns in normal tissues for genes affiliated with Skin Disease

Search GEO for disease gene expression data for Skin Disease.

Pathways for genes affiliated with Skin Disease

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Pathways related to Skin Disease according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0COL17A1, ITGA6
29.9IL8, TNF
39.9IL8, TNF
4
Show member pathways
9.7TNF, ITGA6, LAMC2
5
Show member pathways
9.7GJB3, GJB4
69.7LAMC2, TNF, IL8
7
Show member pathways
9.6TNF, IL8, CCL5
89.6CCL5, IL8, TNF
99.6CCL5, TNF, IL8
10
Show member pathways
9.6LAMC2, DST, ITGA6, COL17A1
11
Show member pathways
9.6COL17A1, LAMC2, ITGA6, DST
12
Show member pathways
9.6DST, COL17A1, ITGA6, LAMC2
13
Show member pathways
9.4TNF, CCL5, ITGA6, IL8
14
Show member pathways
9.4IL8, ITGA6, CCL5, TNF
15
Show member pathways
9.4IL8, IQGAP1, TNF, CCL5
16
Show member pathways
9.3IQGAP1, LAMC2, DST, ITGA6, COL17A1
17
Show member pathways
9.3LAMC2, IL8, ITGA6, COL17A1, CCL5
18
Show member pathways
8.7TNF, LAMC2, CCL5, ITGA6, IL8, IQGAP1

Compounds for genes affiliated with Skin Disease

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Compounds related to Skin Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1ena 784410.4CCL5, IL8
2rebamipide4410.3CCL5, IL8
3loratadine44 24 1112.3IL8, CCL5
4cilomilast4410.3TNF, IL8
5mcp 14410.3CCL5, IL8
6n-tosyl-l-phenylalanine chloromethyl ketone4410.3TNF, IL8
7taurine chloramine4410.3TNF, IL8
8gabexate mesilate4410.3IL8, TNF
9ulinastatin4410.3IL8, TNF
10pranlukast44 28 1112.3CCL5, TNF
11toxin-14410.2IL8, TNF
12salmeterol44 50 28 1113.2IL8, CCL5
13kalinin4410.2LAMC2, ITGA6, DST
14gold sodium thiomalate4410.2TNF, IL8
15gold4410.1COL17A1, LAMC2, DST
16aebsf4410.1IL8, TNF
17mip 1alpha4410.1IL8, CCL5, TNF
18groalpha4410.1TNF, CCL5, IL8
19gm-csf44 2811.1TNF, CCL5, IL8
20triptolide4410.1IL8, CCL5, TNF
21budesonide44 50 1112.1CCL5, TNF, IL8
22fluticasone propionate44 50 61 1113.1TNF, IL8, CCL5
23poly(i-c)4410.1CCL5, TNF, IL8
24il 104410.1IL8, TNF, CCL5
25tarc4410.0IL8, TNF, CCL5
26peptidoglycan44 2811.0TNF, CCL5, IL8
27ccl344 2811.0TNF, CCL5, IL8
28pdtc4410.0IL8, CCL5, TNF
29leukotriene b444 61 2412.0CCL5, TNF, IL8
30sp 60012544 6111.0IL8, CCL5, TNF
315 aminosalicylic acid4410.0IL8, TNF
32scrambled 10panx6110.0GJB4, GJB3
33hydrocortisone44 2 61 1113.0TNF, CCL5, IL8
34carbenoxolone disodium6110.0GJB3, GJB4
35gap 276110.0GJB3, GJB4
36herbimycin a44 6111.0TNF, IL8, ITGA6
3710panx6110.0GJB4, GJB3
38egcg4410.0IL8, CCL5, TNF
39il-124410.0IL8, TNF
40simvastatin44 50 61 28 24 1114.9IL8, CCL5, TNF
41octanol28 2410.9GJB4, GJB3
42staurosporin449.9IL8, TNF
43endotoxin449.8TNF, IL8, CCL5
44pd 98,059449.8TNF, IL8, CCL5, ITGA6
45imiquimod44 61 28 1112.8TNF, IL8
46fmlp449.8IL8, TNF, CCL5
47nacl449.7COL17A1, CCL5, DST
48tpck449.6TNF, IL8
49cycloheximide449.6TNF, DST, CCL5, IL8, COL17A1
50serine449.2CDSN, TNF, CCL5, IL8, COL17A1, IQGAP1

GO Terms for genes affiliated with Skin Disease

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Cellular components related to Skin Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal plasma membraneGO:00992510.0DST, ITGA6
2hemidesmosomeGO:0300569.9COL17A1, ITGA6, DST
3basement membraneGO:0056049.8DST, ITGA6, COL17A1
4cell leading edgeGO:0312529.7IQGAP1, DST
5connexon complexGO:0059229.6GJB4, GJB3
6extracellular regionGO:0055768.9TNF, LAMC2, CCL5, IL8, COL17A1, CDSN

Biological processes related to Skin Disease according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of G-protein coupled receptor protein signaling pathwayGO:04574410.1CCL5, IL8
2neutrophil activationGO:04211910.1CCL5, IL8
3positive regulation of phosphorylationGO:04232710.1ITGA6, CCL5
4cellular response to fibroblast growth factor stimulusGO:04434410.1IL8, CCL5
5embryonic digestive tract developmentGO:04856610.1TNF, IL8
6cell junction assemblyGO:03432910.1COL17A1, ITGA6, LAMC2
7epidermis developmentGO:00854410.0LAMC2, COL17A1, CDSN
8cellular response to organic cyclic compoundGO:0714079.9ITGA6, TNF, CCL5
9lipopolysaccharide-mediated signaling pathwayGO:0316639.9TNF, CCL5
10negative regulation of viral genome replicationGO:0450719.9TNF, CCL5
11hemidesmosome assemblyGO:0315819.9COL17A1, LAMC2, DST, ITGA6
12protein kinase B signalingGO:0434919.8CCL5, TNF
13cell communicationGO:0071549.8GJB4, GJB3
14cellular response to interleukin-1GO:0713479.6IL8, CCL5
15extracellular matrix organizationGO:0301989.5LAMC2, DST, ITGA6, COL17A1, TNF

Products for genes affiliated with Skin Disease

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Sources for Skin Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet